Biocarta Pathways Dataset

Description sets of proteins participating in pathways from Biocarta
Measurement association by literature curation
Association protein-pathway associations from curated pathways
Category structural or functional annotations
Resource Biocarta
Last Updated 2014 Dec 17
  1. 1396 genes
  2. 254 pathways
  3. 4417 gene-pathway associations

Data Access



  • Attribute Similarity

  • Gene Attribute

  • Gene Similarity

pathway Gene Sets

254 sets of proteins participating in pathways from the Biocarta Pathways dataset.

Gene Set Description
acetylation and deacetylation of rela in nucleus
actions of nitric oxide in the heart
activation of camp-dependent protein kinase pka
activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor
activation of pkc through g-protein coupled receptors
adp-ribosylation factor
agrin in postsynaptic differentiation
ahr signal transduction pathway
akap95 role in mitosis and chromosome dynamics
akt signaling pathway
alk in cardiac myocytes
alpha-synuclein and parkin-mediated proteolysis in parkinson`s disease
alternative complement pathway The alternative pathway is one of the three biochemical pathways of the complement system. Stable activation of the alternative pathway occurs on microbial cell surfaces.
angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling
anthrax toxin mechanism of action
antigen processing and presentation The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
antisense pathway
apoptotic dna-fragmentation and tissue homeostasis
apoptotic signaling in response to dna damage
aspirin blocks signaling pathway involved in platelet activation
atm signaling pathway The ataxia telangiectasia-mutated (ATM) serine/threonine kinase mediated signaling plays a major role in the response to DNA double strand breaks (DSB). Following lesion sensing by the MRN complex, ATM gets activated. Active ATM phosphorylates itself and targets resulting in triggering of DNA repair, cell cycle checkpoint and signaling pathways. While ATM signaling is best documented for its role in DSB responses, evidence accumulates that it functions in a range of other, DNA damage unrelated, responses.
attenuation of gpcr signaling
b cell survival pathway
basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression
basic mechanisms of sumoylation
bcr signaling pathway
bioactive peptide induced signaling pathway
bone remodeling The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
brca1 dependent ub ligase activity
btg family proteins and cell cycle regulation
ca-calmodulin-dependent protein kinase activation
cadmium induces dna synthesis and proliferation in macrophages
calcium signaling by hbx of hepatitis b virus
cardiac protection against ros
carm1 and regulation of the estrogen receptor
caspase cascade in apoptosis
cbl mediated ligand-induced downregulation of egf receptors pathway
ccr3 signaling in eosinophils
cd40l signaling pathway
cdc25 and chk1 regulatory pathway in response to dna damage
cdk regulation of dna replication
cell cycle: g1/s check point
cell cycle: g2/m checkpoint
cell to cell adhesion signaling
ceramide signaling pathway Ceramide signaling can act as a lipid second messenger or as a mediator of various cellular signaling pathways by promoting receptor clustering. The pathway plays important roles in apoptosis.
chaperones modulate interferon signaling pathway
chrebp regulation by carbohydrates and camp
chromatin remodeling by hswi/snf atp-dependent complexes
classical complement pathway The classical complement pathway is one of the three biochemical pathways of the complement system. It is activated by antigen-bound antibodies.
control of gene expression by vitamin d receptor
control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk)
corticosteroids and cardioprotection
ctcf: first multivalent nuclear factor
cxcr4 signaling pathway A series of molecular signals initiated by a the C-X-C chemokine type 4 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription.
cyclin e destruction pathway
cycling of ran in nucleocytoplasmic transport
cyclins and cell cycle regulation
cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway
d4gdi signaling pathway
degradation of the rar and rxr by the proteasome
deregulation of cdk5 in alzheimers disease
dicer pathway
double stranded rna induced gene expression
downregulated of mta-3 in er-negative breast tumors
e2f1 destruction pathway
effects of calcineurin in keratinocyte differentiation
egf signaling pathway
eicosanoid metabolism The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids.
endocytotic role of ndk phosphins and dynamin
epo signaling pathway Erythropoietin (EPO) signaling is crucial for the production of blood cell or erythropoiesis and also plays important roles in wound healing and responses to neural injury. EPO is a glycoprotein hormone and also a cytokine whose receptor belongs to type I cytokine receptor. The pathway engages the Jak-Stat intracellular cascade.
er associated degradation (erad) pathway
erk and pi-3 kinase are necessary for collagen binding in corneal epithelia
erk1/erk2 mapk signaling pathway
erythropoietin mediated neuroprotection through nf-kb
estrogen responsive protein efp controls cell cycle and breast tumors growth
eukaryotic protein translation
extrinsic prothrombin activation pathway
fas signaling pathway (cd95)
fc epsilon receptor i signaling in mast cells
fibrinolysis pathway
fmlp induced chemokine gene expression in hmc-1 cells
fosb gene expression and drug abuse
g-protein signaling through tubby proteins
g-secretase mediated erbb4 signaling pathway
gamma-aminobutyric acid receptor life cycle pathway
gata3 participate in activating the th2 cytokine genes expression
generation of amyloid b-peptide by ps1
granzyme a mediated apoptosis pathway
growth hormone signaling pathway The growth hormone signaling pathway is an important regulator of postnatal development. However, despite many years of research, the molecular mechanism underlying its many actions are incompletely understood. It is believed that its actions involve direct and indirect routes. An example of the latter is the role the pathway plays in stimulating the production of insulin-like growth factor.
hemoglobins chaperone
hiv-1 defeats host-mediated resistance by cem15
hiv-1 nef: negative effector of fas and tnf
hop pathway in cardiac development
how does salmonella hijack a cell
how progesterone initiates the oocyte maturation
human cytomegalovirus and map kinase pathways
hypoxia and p53 in the cardiovascular system
hypoxia-inducible factor in the cardivascular system
ifn alpha signaling pathway
ifn gamma signaling pathway
igf-1 signaling pathway
il 2 signaling pathway Interleukin-2 is the prototypical member of the interleukin-2 family of cytokines. The signaling pathway initiated by Il-2 and the other family members activates the Jak-Stat intracellular cascade to regulate T cell, innate and adaptive immune responses.
il 3 signaling pathway Interleukin-3 signaling plays important roles in the function of hematopoietic cells.
il 4 signaling pathway Interleukin-4 is a member of interleukin 2 family of cytokine whose signaling is important for the differentiation of naive T helper cells.
il 6 signaling pathway Interleukin-6 signaling is involved in a wide range of biological processes such as immune regulation, inflammation, hematopoiesis and oncogenesis. A signal transducer common to all family members, gp130 activates Jak-Stat and Raf/Mek/Erk signaling pathways.
il-10 anti-inflammatory signaling pathway
il-2 receptor beta chain in t cell activation
il-7 signal transduction
il12 and stat4 dependent signaling pathway in th1 development
il22 soluble receptor signaling pathway
inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
induction of apoptosis through dr3 and dr4/5 death receptors
influence of ras and rho proteins on g1 to s transition
inhibition of cellular proliferation by gleevec
inhibition of huntingtons disease neurodegeneration by histone deacetylase inhibitors
inhibition of matrix metalloproteinases
insulin signaling pathway Insulin, the peptide hormone, secreted by the pancreatic beta cells, plays essential roles in glucose and energy homeostasis. Insulin signaling activates two main intracellular pathways to regulate carbohydrate and fat metabolism and to prompt glucose absorption in insulin sensitive tissues such as skeletal muscle and adipocytes. Deregulation of the pathway has been associated with a number of conditions, primarily diabetes.
integrin signaling pathway
internal ribosome entry pathway
intrinsic prothrombin activation pathway
ion channels and their functional role in vascular endothelium
ionomycin and phorbal ester signaling pathway
keratinocyte differentiation The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.
lck and fyn tyrosine kinases in initiation of tcr activation
lectin induced complement pathway
links between pyk2 and map kinases
lissencephaly gene (lis1) in neuronal migration and development
map kinase inactivation of smrt corepressor
mapkinase signaling pathway
mcalpain and friends in cell motility
mechanism of acetaminophen activity and toxicity
mechanism of gene regulation by peroxisome proliferators via ppara
mechanism of protein import into the nucleus
mechanisms of transcriptional repression by dna methylation
melanocyte development and pigmentation pathway
metabolism of anandamide an endogenous cannabinoid
mets affect on macrophage differentiation
mtor signaling pathway mTOR signaling pathway regulates cellular processes such as translation, ribosome biogenesis, cell growth and autophagy and is regulated or responds to growth factors, energy metabolites and/or levels of nutrients.
multi-drug resistance factors
multi-step regulation of transcription by pitx2
multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation
nerve growth factor pathway (ngf)
neuroregulin receptor degredation protein-1 controls erbb3 receptor recycling
nf-kb signaling pathway
nfat and hypertrophy of the heart
nfkb activation by nontypeable hemophilus influenzae
nitric oxide signaling pathway
no2-dependent il-12 pathway in nk cells
nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells
opposing roles of aif in apoptosis and cell survival
overview of telomerase protein component gene htert transcriptional regulation
overview of telomerase rna component gene hterc transcriptional regulation
oxidative stress induced gene expression via nrf2
p38 mapk signaling pathway A SAPK MAPK pathway that plays an important role in inflammation and may be involved in several forms of cancer.
p53 signaling pathway p53 transcription factor is a tumor suppressor frequently mutated in cancer. p53 is at the hub of many signaling and regulatory pathways. In response to various stresses, it promotes apoptosis, cell cycle arrest and other defense pathways via transcription dependent as well as independent routes. A key regulator of p53 is Mdm2. Mdm2 is a transcriptional target of p53 thus providing a negative feedback loop.
pdgf signaling pathway PDGF signaling pathway plays an important role in the regulation of cell growth and survival.
pelp1 modulation of estrogen receptor activity
pertussis toxin-insensitive ccr5 signaling in macrophage
phosphatidylcholine biosynthesis pathway
phosphoinositides and their downstream targets
phospholipase c delta in phospholipid associated cell signaling
phospholipase c signaling pathway
phospholipase c-epsilon pathway
phospholipids as signalling intermediaries
phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway
pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase
platelet amyloid precursor protein pathway
polyadenylation of mrna
prion pathway
proteasome complex A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
protein kinase a at the centrosome
proteolysis and signaling pathway of notch
pten dependent cell cycle arrest and apoptosis
rac1 cell motility signaling pathway
ras signaling pathway
ras-independent pathway in nk cell-mediated cytotoxicity
rb tumor suppressor/checkpoint signaling in response to dna damage
regulation of bad phosphorylation
regulation of cell cycle progression by plk3
regulation of ck1/cdk5 by type 1 glutamate receptors
regulation of eif-4e and p70s6 kinase
regulation of eif2
regulation of map kinase pathways through dual specificity phosphatases
regulation of p27 phosphorylation during cell cycle progression
regulation of pgc-1a
regulation of spermatogenesis by crem
regulation of splicing through sam68
regulation of transcriptional activity by pml
regulators of bone mineralization
repression of pain sensation by the transcriptional regulator dream
reversal of insulin resistance by leptin
rho cell motility signaling pathway
rho-selective guanine exchange factor akap13 mediates stress fiber formation
rna polymerase iii transcription
role of brca1 brca2 and atr in cancer susceptibility
role of egf receptor transactivation by gpcrs in cardiac hypertrophy
role of erbb2 in signal transduction and oncology
role of erk5 in neuronal survival pathway
role of mal in rho-mediated activation of srf
role of mef2d in t-cell apoptosis
role of mitochondria in apoptotic signaling
role of nicotinic acetylcholine receptors in the regulation of apoptosis
role of parkin in ubiquitin-proteasomal pathway
role of pi3k subunit p85 in regulation of actin organization and cell migration
role of ppar-gamma coactivators in obesity and thermogenesis
role of ran in mitotic spindle regulation
role of ß-arrestins in the activation and targeting of map kinases
roles of ß arrestin dependent recruitment of src kinases in gpcr signaling
ß-arrestins in gpcr desensitization
segmentation clock
signal dependent regulation of myogenesis by corepressor mitr
signal transduction through il1r
signaling pathway from g-protein families
skeletal muscle hypertrophy is regulated via akt-mtor pathway
sodd/tnfr1 signaling pathway
sonic hedgehog receptor ptc1 regulates cell cycle
spliceosomal assembly
sprouty regulation of tyrosine kinase signals
srebp control of lipid synthesis
stat3 signaling pathway
stathmin and breast cancer resistance to antimicrotubule agents
stress induction of hsp regulation
sumoylation as a mechanism to modulate ctbp-dependent gene responses
sumoylation by ranbp2 regulates transcriptional repression
t cell receptor signaling pathway A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
telomeres telomerase cellular aging and immortality
tgf beta signaling pathway
the 41bb-dependent immune response
the co-stimulatory signal during t-cell activation
the igf-1 receptor and longevity
the information processing pathway at the ifn beta enhancer
the prc2 complex sets long-term gene silencing through modification of histone tails
thrombin signaling and protease-activated receptors
tnf/stress related signaling
tnfr1 signaling pathway
tnfr2 signaling pathway
toll-like receptor pathway
tpo signaling pathway
transcription factor creb and its extracellular signals
transcription regulation by methyltransferase of carm1
transcriptional activation of dbpb from mrna
trefoil factors initiate mucosal healing
trka receptor signaling pathway
tsp-1 induced apoptosis in microvascular endothelial cell
tumor suppressor arf inhibits ribosomal biogenesis
ucalpain and friends in cell spread
vegf hypoxia and angiogenesis
visceral fat deposits and the metabolic syndrome
visual signal transduction
west nile virus
wnt lrp6 signalling
wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
y branching of actin filaments
yaci and bcma stimulation of b cell immune responses