2075 sets of proteins in protein complexes from the CORUM Protein Complexes dataset.
| Gene Set |
Description |
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DRIP complex
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ORC 2-5 complex (origin recognition 2-5 complex)
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Notch1(N-TM)-Notch1(N-EC) heterodimer complex
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SCAMP1-SCAMP2-SCAMP3 complex
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ORC 1-5 complex (origin recognition 1-5 complex)
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PAR-6-VE-cadherin complex, endothelial
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TMP21-P24 complex
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ITGA2B-ITGB3-ICAM4 complex
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RANBMP-CD39 complex
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hRAD51C-hXRCC3 complex
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Isocitrate dehydrogenase, cytoplasmic
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Egasyn-glucuronidase complex
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SMAD4-SKI complex
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p130Cas-ER-alpha-cSrc-kinase- PI3-kinase p85-subunit complex
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ELMO1-DOCK1 complex
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CSA complex
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ITGAV-ITGB5-ICAM4 complex
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WIP-WASp-actin-myosin-IIa complex
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Retrotranslocation complex
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FHL2-CREB complex
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A protein complex that contains CREB and FHL2, and is involved in transcriptional regulation.
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ASF1-histone containing complex
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CIN85-CBL-SH3GL2-EGFR complex, EGF stimulated
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Prefoldin complex
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A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics.
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TSC1-TSC2 complex
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A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
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CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex
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Apg16L-Apg12-Apg5 complex
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Anti-Sm protein complex
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IL12A homodimer complex
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ARF-Mule complex
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Decapping complex
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G protein complex (MCF2, GNB1, GNG2)
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PTIP-DNA damage response complex
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TGF-beta-receptor-PAR6 complex
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TLE1-TLE2 complex
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SKI-SMAD2-SMAD4 pentameric complex
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Ubiquitin E3 ligase (TRIM25, DDX58)
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MutS-alpha-PK-zeta complex
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BRD4-RFC complex
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TBPIP/HOP2-MND1 complex
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GammaH2AFX-NDHII-Ku70-DNA complex
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VILIP-1-AChR-alpha-4-AChR-beta-2 complex
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MRN complex (MRE11-RAD50-NBS1 complex)
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Gata1-Tal1-Tcf3-Lmo2 complex
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A protein complex that contains the zinc finger transcription factor GATA1, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis.
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Pcdhga1-Pcdha4 complex
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A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane.
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ITGAV-ITGB1 complex
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PCNA-DNA polymerase delta complex
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FAS-FADD-CASP10 complex
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Ternary complex (TRAF2, FADD, TRADD)
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Wave-2 complex
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CDH1-CKS1B complex
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(ER)-localized multiprotein complex, in absence of Ig heavy chains
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TGF-beta receptor II-TGF-beta1 complex
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A protein complex that consists of a dimeric transforming growth factor beta (TGF-beta) type II receptor bound to a TGF-beta1 dimer.
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Ubiquitin-protein ligase (UBE2N, UBE2V2/MMS2)
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eRF1-eRF3-GTP-Mg(2+) complex
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Exon junction complex (EIF4A3-MLN51-MAGOH-Y14)
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HMGB1-HMGB2-HSC70-ERP60-GAPDH complex
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CHL12-RFC2-5 complex
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GluR delta-2 complex, postsynaptic (GluR delta-2, Shank1, Shank2, mGluR1 alpha, Homer, PSD-95)
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DNA ligase IV-XRCC4-AHNK complex
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ITGA2B-ITGB3-F11R complex
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COG complex
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A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p).
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ING4 complex (ING4, MYST2, C1orf149, PHF16)
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Ectodermin-SMAD4 complex
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DNA ligase IV-XRCC4 complex
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A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p.
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Fgf2-Ck2 complex
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BCR-ABL (p185 fusion protein)-GRB2 complex
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Raf1-PP2A core enzyme complex (Ppp2r1a, Ppp2ca), untreated
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SNARE complex (Stx4, Vamp8, Snap23)
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CENP-A nucleosome associated complex
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Multiprotein complex (mRNA turnover)
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ITGA6-ITGB4-SHC1-GRB2 complex
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Exon junction complex (EIF4A3-MLN51-MAGOH-Y14), RNA-protein complex
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E2f5-Rbl2-Hdac1 complex
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immunoproteasome
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eNOS-HSP90-AKT complex, VEGF induced
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TRPC3-TRPC4 channel complex, redox-sensitive
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Agap11-AP3 complex
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RNA polymerase II complex, chromatin structure modifying
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PCNA-MutS-alpha-DNA initial complex
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BRCA1-BARD1-BACH1-DNA damage complex II
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Rab27A-Melanophilin-MyosinVa complex
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IKBKG tetramer complex
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CTCF-nucleophosmin-PARP-HIS-KPNA-LMNA-TOP complex
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Emerin-actin-NMI-(alphaII)spectrin complex
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SMAD1-P300 complex
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COG2-COG3-COG4 subcomplex
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ITGA7-ITGB1-ITGB1BP3 complex
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A protein complex that consists of an alpha7-beta1 integrin complex bound to nicotinamide riboside kinase 2 (also known as muscle integrin binding protein, MIBP).
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EGFR-containing signaling complex
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TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I)
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FIF-FGR2 complex
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BIRC5-AURKB-INCENP-EVI5 complex
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Ubiquitin E3 ligase (CRY1, SKP1A, CUL1, FBXL3)
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BRMS1-SIN3-HDAC complex
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SKI-SMAD2 hexameric complex
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PHAX-CBC complex (cap binding complex)
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Ubiquitin E3 ligase (NFKBIA, FBXW11, BTRC, CUL1, SKP1A)
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MRIP-MBS-RHOA complex
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PlexinA1-NRP1 complex
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CHUK-IKBKB-MAP3K14 complex
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Oligosaccharyltransferase complex (Stt3A variant)
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PGAM5-KEAP1-NRF2 complex
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TRBP containing complex (DICER, TRBP, AGO2, RPL7A, EIF6, MOV10)
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p14-Mp1-Erk1/2 complex
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ITGAV-ITGB3-COL4A3 complex
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A protein complex that consists of an alphaV-beta3 integrin complex bound to tumstatin, the NC1 domain of the alpha3 chain of type IV collagen.
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TRAP-SMCC mediator complex
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ITGA9-ITGB1-VCAM1 complex
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A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular cell adhesion molecule-1.
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Rab27a-melanophilin-myosin-Va complex
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ETS2-FOS-JUN complex
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p50-p65 NF(kappa)B-SRC1 complex
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Pex26-Pex6-Pex1 complex
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BAF complex
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LIN2-LIN7 complex
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CASP8-CHUK-IKBKB-MALT1-BCL10 complex
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CSA-POLIIa complex
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LINC complex, S-phase
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Lnx1-Jam4 complex
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NAT complex
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A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule.
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LAT-PLC-gamma-1-p85-GRB2-SOS signaling complex, C305 activated
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TFIIH transcription factor complex (ERCC2, ERCC3, GTF2H1, CDK7, CCNH, GTF2H2)
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SRC-PRKCD-CDCP1 complex
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ULBP2-KLRK1-HCST complex
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APH1A-PSEN1-NCSTN complex
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CyclinD3-CDK4-CDK6 complex
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Ocrl-Cdc42 complex
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BRAF-RAF1-14-3-3 complex
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GRASP-GRP1 complex
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Metaxin complex
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ITGA2b-ITGB3-CD9 complex
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A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface protein CD9.
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Rb-NeuroD1-Ngfi-B complex
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Rnase/Mrp complex
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A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication.
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REST-CoREST-mSIN3A complex
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ATRX-DAXX complex
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CNS-P53 complex
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CCND2-CDK6 complex
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HSF1-YWHAE complex
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TCF4-CTNNB1-EP300 complex
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Pkhd1-Pkd2 complex
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BLM-TOP3A complex
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NRG1-IKZF4 complex
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hMediator complex (MED23, CDK8, CCNC, MED7)
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Ku70/Ku86 complex
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ITGA2b-ITGB3-CD47-SRC complex
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A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src.
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Microprocessor complex
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A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs.
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CRLR-RAMP3 complex
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SKI-NCOR1-SIN3A-HDAC1 complex
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Meprin A
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Sos1-Abi1-Eps8 complex
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DDB complex
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ITGB1-ITGA9 complex
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Cohesin-SA1 complex
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CIN85-SH3GL2 complex
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p18-Cdk4 complex
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Casein kinase II complex
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A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein.
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Gamma-secretase complex (Aph1a, Ncstn, Psen1, Psenen, Tmp21)
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TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle)
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CIN85-SH3GL3-CBL complex
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SIRT1-HNF4-alpha-PGC-1-alpha complex, in response to fasting
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RFC complex (activator A 1 complex)
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DRIP78-PHLP complex
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Brm-associated complex
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SMAD3-SMAD4-cJUN complex
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Tacc1-chTOG-AuroraA complex
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NRD complex (Nucleosome remodeling and deacetylation complex)
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TIN2 complex
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HSF1-HSF2 complex
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AKAP250-PKA-PDE4D complex
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ING1-p300-PCNA complex
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BRAF53-BRCA2 complex
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ITGAV-ITGB5-SPP1 complex
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A protein complex that consists of an alphav-beta5 integrin complex bound to osteopontin.
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Casein kinase II (beta-dimer, alpha, alpha')
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XPA-ERCC1-ERCC4 complex
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One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively.
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NCBP-NIP1 complex
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A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.
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PLC-gamma-2-SLP-76 complex
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NRP2-VEGFR3 complex
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EBAFa complex
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Binary COG subcomplex
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Cd74-Cd44 receptor complex
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PIP complex
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Agtr1a-Jak2 complex
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Replication-coupled CAF-1-MBD1-ETDB1 complex
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OCT1-SOX2 DNA-protein complex
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COG1-COG8-COG5-COG6-COG7 subcomplex
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TIF1gamma-SMAD2-SMAD3 complex
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Rb-tal-1-E2A-Lmo2-Ldb1 complex
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ITGA6-ITGB4-Laminin10/12 complex
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TGF-beta-receptor II-TGF-beta1 complex
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A protein complex that consists of a dimeric transforming growth factor beta (TGF-beta) type II receptor bound to a TGF-beta1 dimer.
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Caveolar macromolecular signaling complex
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A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3).
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p14-Mp1-MEK1 complex
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ITGA5-ITGB1-SPP1 complex
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A protein complex that consists of an alpha5-beta1 integrin complex bound to osteopontin.
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TBP-TAF complex
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GPI-GnT activity complex
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SH3P2/OSTF1-CBL-SRC complex
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CBF-DNA complex
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Ecsit complex (ECSIT, NDUFS3, TOM20)
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SCAMP1-SCAMP2 complex
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I-kappa-B kinase (IKK) complex
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ING4 complex (ING4, MYST2, C1orf149, PHF15)
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G protein complex (Gngt2, Kcnj3, Gnb1)
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DLP1-hFIS1 complex
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IL6ST-PRKCD-STAT3 complex
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SMAD4-SNO-SKI complex
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Fmrp-Lgl complex
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YY1-MDM2-p53 complex
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ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex
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NOD1 homodimer complex
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TFTC complex (TATA-binding protein-free TAF-II-containing complex)
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SMAD6-HOXC8 complex
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Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex
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ZNF198-PML complex
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NRP1-VEGFR2-VEGF(165) complex
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Bax homooligomeric complex, after apoptotic stimulation
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Ku antigen complex
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BRCA1-BACH1 complex
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TIAM1-GRIN1 complex
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Pcdhga1-Pcdhgb4 complex
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A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane.
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CD20-LCK-FYN-p75/80 complex
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MKP3-CK2alpha complex
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hs4 enhancer complex (slow migrating complex)
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MutL-beta complex
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A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1.
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Caveolar macromolecular signaling complex, using anti-Cav-3
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CF IIAm complex (Cleavage factor IIAm complex)
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MICB-KLRK1-HCST complex
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DNMT1-G9a complex
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TNFRSF11A-TRAF6-SRC complex
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hPRC1L complex
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OAP-1-OSP/claudin-11-ITGB1 complex
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AR-AKT-APPL complex
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ITGA1-ITGB1-COL6A3 complex
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A protein complex that consists of an alpha1-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.
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PCNA-KU antigen complex
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RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying
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Cd2ap-Fyn complex
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SMN complex, U7 snRNA specific
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DNA polymerase delta complex
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SNF2L-RSF1 complex
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BLOC-3 (biogenesis of lysosome-related organelles complex 3)
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PICK1-GRIP1-GLUR2 complex
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EGR-EP300 complex
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CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex
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BLOC-1 (biogenesis of lysosome-related organelles complex 1)
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NuA4/Tip60 HAT complex
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RNA endonuclease (SEN2deltaEx8, SEN54, CLP1)
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SWI/SNF chromatin-remodeling complex
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MDC1-MRE11-RAD50-NBS1 complex
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FACT-NEK9 complex
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ATR-ATRIP complex
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A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A.
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PLCB3-PARD3-PARD6A complex
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MBD1-MCAF complex
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DNA polymerase alpha-primase complex
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MTA1-HDAC core complex
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SMAD2-FAST1 complex
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Tumor necrosis factor receptor 1 signaling complex
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MutL-alpha complex
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A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.
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ACT-CREB complex
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BAX homo-oligomer complex
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RGS6-DNMT1-DMAP1 complex
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A protein complex formed by the association of RGS6, a negative regulator of heterotrimeric G protein signaling, with the DMAP1-Dnmt1 transcriptional repressor complex; in the complex, RGS6 inhibits the transcriptional repressor activity of DMAP1.
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SMCC complex
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(ER)-localized multiprotein complex, Ig heavy chains associated
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B-Ksr1-MEK-MAPK-14-3-3 complex
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Mekk1-Axin complex
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ITGA4-ITGB1-THBS1 complex
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A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-1.
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Set1A complex
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WNK1-OSR1 complex
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Pik3r5-Pik3cg complex
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HDAC1-associated core complex cI
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CARMA1-BCL10-MALT1 complex
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A protein complex comprising Carma1, Bcl10 and MALT1; plays a role in signal transduction during NF-kappaB activation.
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PLXNA1-RANBPM complex
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20S methyltransferase core complex
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RBP-Jkappa-Notch1 complex
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ASPP1-SAM68 complex
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Gamma-secretase-Delta1 complex
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A protein complex that is formed by the association of the Notch ligand Delta1 with the gamma-secretase complex.
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BRCA1 A complex
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A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites.
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PC2 complex
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ERCC2/CAK complex
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AP1 adaptor complex
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A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).
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MDC1-H2AFX-TP53BP1 complex
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Protein phosphatase 4 complex
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The complex formed by the catalytic subunit of protein phosphatase 4 plus a regulatory subunit.
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ITGA6-ITGB1-CYR61 complex
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A protein complex that consists of an alpha6-beta1 integrin complex bound to CYR61, a cysteine-rich protein involved in angiogenesis.
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Bcl-xL-p53-PUMA complex, DNA damage induced
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Quaternary complex (Dvl, Gsk3b, Frat1, Axin1)
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PAC1-PAC2 complex
|
|
|
SNX complex (SNX1a, SNX2, SNX4, EGFR)
|
|
|
MAD1L1 homodimer complex
|
|
|
Raf1-PP2A holoenzyme complex (Ppp2r1a, Ppp2r2b, Ppp2ca), PDGF stimulated
|
|
|
Profilin 1 complex
|
|
|
CRB1-MPP5-INADL complex
|
|
|
SMAD7-SMURF2 complex
|
|
|
PA28-20S proteasome
|
|
|
TIP60 histone acetylase complex
|
A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
|
|
DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1
|
|
|
Integrator-RNAPII complex
|
|
|
BRCA1-core RNA polymerase II complex
|
|
|
ARC-L complex
|
|
|
SIN3-SAP25 complex
|
|
|
ITGAV-ITGB3-EGFR complex
|
A protein complex that consists of an alphaV-beta3 integrin complex bound to epidermal growth factor receptor.
|
|
PLC-gamma-1-Lab-Blnk complex, BCR stimulated
|
|
|
RAF1-PPP2-PIN1 complex
|
|
|
SIN3 complex
|
A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins.
|
|
ELMO1-DOCK1-CRKII complex
|
|
|
SRI homodimer complex
|
|
|
DNA synthesome complex (15 subunits)
|
|
|
Exon junction complex (mRNA splicing-dependent)
|
|
|
MLL1-WDR5 complex
|
|
|
Vps29-Vps35-Vps26a complex
|
|
|
Grancalcin-sorcin complex
|
|
|
p400-associated complex
|
|
|
Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1)
|
|
|
eIF4AIII-Btz complex
|
|
|
FARP2-NRP1-PlexinA3 complex
|
|
|
PKC-alpha-PLD1-PLC-gamma-2 signaling complex, lacritin stimulated
|
|
|
DNA polymerase alpha
|
|
|
VEGF transcriptional complex
|
|
|
SLP-76-PLC-gamma-1-ITK complex, alpha-TCR stimulated
|
|
|
IRAK1-IRAK2 complex
|
|
|
Mitotic 14S cohesin 1 complex
|
|
|
HSP90-FKBP38-CAM-Ca(2+) complex
|
|
|
CTCF-nucleophosmin complex
|
|
|
ER-alpha-c-Jun complex
|
|
|
ITGA3-ITGB1-THBS1 complex
|
A protein complex that consists of an alpha3-beta1 integrin complex bound to thrombospondin.
|
|
NELF complex (Negative elongation factor complex)
|
|
|
Death induced signaling complex DISC (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced
|
|
|
TRF2-Rap1 complex III
|
|
|
Fgr-Pyk2-p190RhoGap complex
|
|
|
Axin-Dvl-Gsk complex
|
|
|
TFTC-type histone acetyl transferase complex
|
|
|
NuA4/Tip60-HAT complex A
|
|
|
NuA4/Tip60-HAT complex B
|
|
|
ERAP1-ERAP2 complex
|
|
|
MTNR1A-MTNR1B complex
|
|
|
Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A)
|
|
|
CTF18-CTF8-DCC1 complex
|
|
|
EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3J)
|
|
|
SEMA6D-PlexinA1-NRP1 complex
|
|
|
RBP-Jkappa-SHARP complex
|
|
|
ITGAV-ITGB3-PPAP2b complex
|
A protein complex that consists of an alphaV-beta3 integrin complex bound to lipid phosphate phosphohydrolase-3.
|
|
TRAP complex
|
|
|
IKBKG-IKBKB complex
|
|
|
ETS2-ETS1 complex
|
|
|
Ubiquitin E3 ligase (CRY2, SKP1A, CUL1, FBXL3)
|
|
|
TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2)
|
|
|
Ksr1 complex (Ksr1, Mek, 14-3-3, Mapk), EGF stimulated
|
|
|
Condensin I-PARP-1-XRCC1 complex
|
|
|
WRN-TRF2 complex
|
|
|
Abcg5-Abcg2 complex
|
|
|
RCP-Rab11 complex
|
|
|
Multicomponent signaling complex, anti-CD40 stimulated,(Birc2, Birc3, Cd40, Ikbkg, Map3k1, Traf2, Ube2n)
|
|
|
LMO4-BRCA1-CTIP-LDB1 complex
|
|
|
SMAD3-SMAD4-cSKI, TGF(beta)-dependent
|
|
|
MutS-alpha complex
|
A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6.
|
|
ITGA2B-ITGB3-CIB1 complex
|
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin.
|
|
Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1)
|
|
|
APH1A-PSEN2-NCSTN complex
|
|
|
Cbl-Crkl-Rapgef1 complex
|
|
|
BCL10-CHUK-BCL10-IKBKB complex
|
|
|
RNA polymerase II (RNAPII)
|
|
|
p16-cyclin D2-CDK4 complex
|
|
|
ITGAV-ITGB3-NOV complex
|
|
|
SRm160-SRm300 complex
|
|
|
NUMB-TP53-MDM2 complex
|
|
|
Slam-SAP-FynT complex
|
|
|
IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14)
|
|
|
Ccd1-Mekk4 complex
|
|
|
CASK-MINT complex
|
|
|
Chromatin remodeling complex (TACC2, TACC3, PCAF)
|
|
|
POSH-AKT2 complex
|
|
|
TOP1-PSF-P54 complex
|
|
|
Pax7-HMT complex
|
|
|
CAK-ERCC2 complex
|
A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2.
|
|
MLL-HCF complex
|
|
|
pRb2/p130-multimolecular complex (RB2, E2F4, HDAC1, SUV39H1, P300)
|
|
|
ITGA5-ITGB1-FN-1-NOV complex
|
A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and the extracellular matrix protein NOV.
|
|
Checkpoint 9-1-1 complex
|
|
|
CAS-SRC-FAK complex
|
|
|
P53-BARD1-Ku70 complex
|
|
|
NPC subcomplex (NUP98, NUP107, NUP133, NUP160)
|
|
|
NEMO-HIF2(alpha)-ARNT complex
|
|
|
CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex
|
|
|
SNARE complex (RINT1, ZW10, p31)
|
|
|
FAS-FADD-CASP8-CASP10 complex
|
|
|
FHL4/STX11-ACT complex
|
|
|
Girdin homo-oligomer complex
|
|
|
mTOR-signaling complex (FRAP1/mTOR, GBL, RAPTOR)
|
|
|
DDEF1-CTTN-PXN complex
|
|
|
TRP1-G alpha-11-IP3R3-CAV1 signaling complex
|
|
|
S100A10-annexin 2 complex
|
|
|
Nmi-Rrn3 complex
|
|
|
RAG1-RAG2 tetramer complex
|
|
|
TNF-alpha/NF-kappa B signaling complex 10
|
|
|
Prune-Gelsolin complex
|
|
|
TANK-TRAF2-TRAF3 complex
|
|
|
TRAF2-cIAP1/BIRC2 complex
|
|
|
CENP-A NAC-CAD complex
|
|
|
DNMT1-G9a-PCNA complex
|
|
|
S-phase-specific E2F-p107 complex
|
|
|
Axin-Mekk4 complex
|
|
|
TFIIA complex
|
|
|
TEAD2-YAP DNA-protein complex
|
|
|
LSm1-7 complex
|
|
|
Pericentrin-GCP complex
|
|
|
Adiponectin homotrimer complex
|
|
|
TorsinA-TorsinB complex
|
|
|
Ubiquitin E3 ligase (FBXO18, SKP1A, CUL1, RBX1)
|
|
|
Axin2-Ctnnb1-Apc complex
|
|
|
SMAD3-cSKI-SIN3A-HDAC1 complex
|
|
|
6S methyltransferase and RG-containing Sm proteins complex
|
|
|
DMAP1-associated complex
|
|
|
Ubiquitin E3 ligase (NIPA, SKP1A, CUL1, RBX1)
|
|
|
GNAQ-GEFT-RHOA complex
|
|
|
eNOS-CAV1 complex
|
|
|
MAF2 complex
|
|
|
IKBA-NF(kappa)Bp65-NF(kappa)Bp50 complex
|
|
|
ESCRT-II complex
|
An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes.
|
|
Polycystin-1-E-cadherin-beta-catenin-Flotillin-2 complex
|
|
|
ING5 complex
|
|
|
IL2-IL2RA-IL2RB complex
|
|
|
LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated
|
|
|
CD19-Vav-PI 3-kinase (p85 subunit) complex
|
A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K).
|
|
SNAPc (small nuclear RNA-activating protein) complex
|
|
|
Olfr992-Reep1 complex
|
|
|
DNMT3B complex
|
|
|
Oligosaccharyltransferase complex (Stt3B variant)
|
|
|
MASH1 promoter-coactivator complex
|
|
|
CRM1-Survivin-AuroraB mitotic complex
|
|
|
Respiratory chain complex I, mitochondrial
|
|
|
Crb1-Mupp1-Pals1-Mpp4 complex
|
|
|
TCF4-CTNNB1-CREBBP complex
|
|
|
Ubiquitin E3 ligase (Fbxo32, Skp1a, Cul1, Rbx1)
|
|
|
Mediator complex
|
A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
|
|
PCNA-MSH2-MSH6 complex
|
|
|
P-TEFb.1 complex
|
|
|
CAV1-VDAC1-ESR1 complex
|
|
|
CDK8-MED6-PARP1 complex
|
|
|
CRM1-Survivin mitotic complex
|
|
|
Respiratory chain complex I (incomplete NDUFAF1 assembly), mitochondrial
|
|
|
G protein complex (Btk, Gng2, Gnb1)
|
A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein.
|
|
SEMA4A-PlexinD1 complex
|
|
|
MAF1 complex
|
|
|
YY1-Notch1-RBP-Jkappa complex
|
|
|
PAX6-SOX2 DNA-protein complex
|
|
|
APP-TIMM23 complex
|
|
|
CAND1-CUL4B-RBX1 complex
|
|
|
Gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)
|
A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein.
|
|
Pcdha7-Pcdhga1 complex
|
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane.
|
|
Ribosome, cytoplasmic
|
|
|
Sirpa-Pik3cg complex
|
|
|
Respiratory chain complex I (intermediate VII/650kD), mitochondrial
|
|
|
Tmsb4x-Lims1-Ilk complex
|
|
|
Nogo-potassium channel complex
|
|
|
APPBP1-UBA3 complex
|
|
|
PIDDsome complex
|
|
|
Trip(Br2)-Dp1-E2F1 complex
|
|
|
FOXO3-PCAF complex, oxidative stress stimulated
|
|
|
Bad-Gk-Wave1-Pkaca-Ppp1cc complex
|
|
|
ULBP3-KLRK1-HCST complex
|
|
|
RB1-TFAP2A complex
|
|
|
ITGB5-ITGAV-VTN complex
|
|
|
Cell-cell junction complex (ARHGAP10-CTNNA1)
|
|
|
TAF4-TAF12 subcomplex of TFIID complex
|
|
|
Ubiquilin-proteasome complex
|
|
|
PAR6-CDC42 complex
|
|
|
GABBR2-HTR1A complex
|
|
|
CDC2-CCNB1-PTCH1 complex
|
|
|
Polyadenylation complex (CSTF1, CSTF2, CSTF3, SYMPK CPSF1, CPSF2, CPSF3)
|
|
|
NK-3-Groucho complex
|
|
|
RAD17-RFC complex
|
|
|
RasGAP-AURKA/AURKB-survivin complex
|
|
|
DNA ligase IV-Xrcc4-DNA-protein kinase complex
|
|
|
Kir4.1-beta-dystroglycan complex, cortical astrocytes
|
|
|
CycD1-Cdk4 complex
|
|
|
TGF-beta receptor II-TGF-beta receptor I-TGF-beta3 complex
|
|
|
SNARE complex (Vti1b, Stx7, Stx8, Vamp8)
|
|
|
CAND1-CUL3-RBX1 complex
|
|
|
GALNS-lysosomal hydrolase 1.27 MDa complex
|
A protein complex found in the lysosome that contains beta-galactosidase, cathepsin A, alpha-neuraminidase and N-acetylgalactosamine-6-sulfate sulfatase, and is involved in glycosaminoglycan catabolism.
|
|
Notch1-p56lck-PI3K complex
|
|
|
PAR4-BACE1 complex
|
|
|
PARVB-ARHGEF6 complex
|
|
|
CEN complex
|
|
|
CyclinD3-CDK4-CDK6-p21 complex
|
|
|
CD8A-LCK complex
|
|
|
SNARE complex (Stx4, Stx6, Stx7, Vamp3, Vamp7, Vamp8, Vti1b)
|
|
|
ITK-SLP-76 complex, anti-TCR stimulated
|
|
|
NUMAC complex (nucleosomal methylation activator complex)
|
|
|
Ubiquitin E3 ligase (ASB1, TCEB1, TCEB2, CUL5, RNF7)
|
|
|
RNF11-SMURF2-STAMBP complex
|
|
|
SRm160/300 complex
|
|
|
Remodeling and spacing factor (RSF) complex
|
|
|
RUNX1-CBF-beta-DNA complex
|
|
|
Ubiquitin E3 ligase (Fbxl20, Skp1, Cul1)
|
|
|
TGF-beta-receptor type II homodimer complex
|
|
|
EB1-APC-mDia2 complex
|
|
|
Smad3-Smad4 complex
|
A heteromeric SMAD protein complex that contains SMAD3 and SMAD4.
|
|
FHL3-CREB complex
|
A protein complex that contains CREB and FHL3, and is involved in transcriptional regulation.
|
|
Cd3d-Cd3g-Cd3e-Cd247 complex
|
|
|
MR-UBC9-SRC1 complex
|
|
|
NFAT-JUN-FOS DNA-protein complex
|
|
|
Notch2(N-TM)-Notch2(N-EC)-Delta complex
|
|
|
5S-DNA-TFIIIA-TFIIIC2-TFIIIB subcomplex
|
|
|
PA28gamma-20S proteasome
|
|
|
Respiratory chain complex I (lambda subunit) mitochondrial
|
|
|
Mi2/NuRD complex
|
|
|
MeCP1 complex
|
|
|
FAK-beta5 integrin complex, VEGF induced
|
|
|
Membrane protein complex (DERL1, SELS, VCP)
|
|
|
ZO1-(beta)cadherin-(VE)cadherin-VEGFR2 complex
|
|
|
MCM complex
|
A hexameric protein complex required for the initiation and regulation of DNA replication.
|
|
SNARE complex (VAMP2, SNAP25, STX1a, CPLX1)
|
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof).
|
|
Ksr1-PP2A core enzyme complex (Ppp2r1a, Ppp2ca), untreated
|
|
|
TDT-TDIF2-core-histone complex
|
|
|
ITGA4-ITGB1-JAM2 complex
|
A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell adhesion molecule JAM2.
|
|
NRP2-VEGFD complex, heparin dependent
|
|
|
CCNC-CDK3 complex
|
|
|
PPD complex
|
|
|
DGCR8-NCL complex
|
|
|
P-TEFb-BRD4-TRAP220 complex
|
|
|
uKHC-KLC1-KLC2 kinesin complex
|
|
|
SNF2h-cohesin-NuRD complex
|
|
|
p97/VCP homohexamer complex
|
|
|
PBAF complex (Polybromo- and BAF containing complex)
|
|
|
P-TEFb.2 complex
|
|
|
Frs2-Shp2 complex, FGF stimulated
|
|
|
Scrib-beta-PIX-GIT1 complex
|
|
|
Vezf1-p68RacGap complex
|
|
|
Class C Vps complex (VPS11, VPS18, STX7)
|
|
|
Homodimeric complex LTBR
|
|
|
KLC2-nKHC-uKHC kinesin complex
|
|
|
ACT homodimer complex
|
|
|
BLM complex III
|
|
|
Prolyl 4-hydroxylase (alpha(I)-type)
|
|
|
Retn homohexamer complex
|
|
|
CDC2-PCNA-CCNB1-GADD45A complex
|
|
|
ITGAV-ITGB5 complex
|
|
|
Apoptosome
|
A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms.
|
|
Exon junction complex, EIF4A3-MLN51-MAGOH-Y14 (RNA-protein complex)
|
|
|
MTNR1A homodimer complex
|
|
|
FA core complex (Fanconi anemia core complex)
|
|
|
Ubiquitin E3 ligase (ASB6, TCEB1, TCEB2, CUL5, RNF7)
|
|
|
BRCA1 C complex
|
A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint.
|
|
TIAM1-EFNB1-EPHA2 complex
|
|
|
Set1B complex
|
|
|
SMAD2-SMAD4-FAST1 complex
|
|
|
CIN85 homotetramer complex
|
|
|
Cytochrome bc1-complex (EC 1.10.2.2), mitochondrial
|
|
|
RAD9-RAD1-HUS1-POLB complex
|
|
|
ERCC1-ERCC4-MSH2 complex
|
|
|
PML-SMAD2/3-SARA complex
|
|
|
ITGA9-ITGB1-ADAM8 complex
|
A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8.
|
|
RICTOR-mTOR complex
|
|
|
SMAD3-SKI-NCOR complex
|
|
|
G protein complex (HDAC5, GNB1, GNG2)
|
|
|
AP3D1-AP3S2 complex
|
|
|
RAD51L3-XRCC2 complex
|
|
|
TRPC1-STIM1-ORAI1 complex
|
|
|
CCND3-CDK6 complex
|
|
|
COP9 signalosome complex (Gps1, Cops1, Cops2, Cops3, Cops4, Cops5, Cops6, Cops7a, Cops7b, Cops8)
|
|
|
BRCA1-BARD1-BRCA2-DNA damage complex III
|
|
|
Spen-Hivep1 complex
|
|
|
Caspase-2-TRAF2-RIP1 complex
|
|
|
SNARE complex (VAMP2, SNAP25, STX1a, CPLX1, CPLX3)
|
|
|
Vdr-Med4 complex
|
|
|
CCNC-CDK8-MED1-MED6-MED7 xcomplex
|
|
|
ITGA4-PXN-GIT1 complex
|
|
|
CPSF6-ITCH-NUDT21-POLR2A-UBAP2L complex
|
|
|
ADAR1-CDK2 complex
|
|
|
Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5)
|
|
|
C-CFTR-NHERF(PDZ1 domain)-ezrin complex
|
|
|
ITGA7-ITGB1-CD151 complex
|
A protein complex that consists of an alpha7-beta1 integrin complex bound to the tetraspanin CD151.
|
|
ITGA5-ITGB4 complex
|
|
|
ITCH-FAM/USP9x complex
|
|
|
BCL6-HDAC7 complex
|
|
|
Hnf4-Pc4 complex
|
|
|
Cell cycle kinase complex CDC2
|
|
|
HESX1-TLE1 complex
|
|
|
SMAD1-CBP complex
|
|
|
HTR1B homodimer complex
|
|
|
SMN complex
|
A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus.
|
|
NCOR complex
|
|
|
Condensin II
|
|
|
CDK2-CCNE1 complex
|
|
|
MAML1-RBP-Jkappa-Notch1 complex
|
A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
|
|
MED18-MED20-MED29 mediator subcomplex
|
|
|
Abcg5-Abcg8 complex
|
|
|
ITGB1-RAP1A-PKD1 complex
|
|
|
PRL receptor (PRLR) dimer complex
|
|
|
5S-DNA-TFIIIA-TFIIIC2 subcomplex
|
|
|
MRG15-PAM14-RB complex
|
|
|
Kinase-scaffold-phosphatase complex, PKA-AKAP79-CaN
|
|
|
Lef1-Tle1 complex
|
|
|
Abcg5-Abcg4 complex
|
|
|
Shp2-Sos complex, FGF stimulated
|
|
|
MAML2-RBP-Jkappa-Notch3 complex
|
A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
|
|
AIRE homodimer complex
|
|
|
ITGAV-ITGB3-ADAM23 complex
|
A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM23.
|
|
STAGA core complex (SPT3-TAF9-GCN5 acetyltransferase complex)
|
|
|
VHL-TCEB1-TCEB2 complex
|
|
|
TRF1-TIN2 complex
|
|
|
Kir3.2 homotetramer complex
|
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|
mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN)
|
|
|
RB1(hypophosphorylated)-E2F4 complex
|
|
|
p53-SP1 complex
|
|
|
ClpP complex, heptameric
|
|
|
HDAC1-associated core complex cII
|
|
|
Phosphatidylinositol 3-kinase (PIK3CA, PIK3R1)
|
|
|
SMN containing complex
|
|
|
CIN85-CBL-SH3GL2 complex
|
|
|
NGF-p75 complex
|
|
|
WDR5-ASH2L-RBBP5-MLL2 complex
|
|
|
PLC-gamma-2-Lab-Blnk complex, BCR stimulated
|
|
|
Cohesin complex, incomplete (Rec8, Crest/Ss18I1)
|
|
|
FOXO1-FHL2-SIRT1 complex
|
|
|
RAD51C-XRCC3 complex
|
A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof.
|
|
Itgb1-Rap1a-Prkd1 complex
|
|
|
SMAD3-SMAD4-FOXO4 complex
|
|
|
Cohesin complex, incomplete (Stag3, Sycp3)
|
|
|
Kir4.1-alpha-1-syntrophin complex, whole brain lysate
|
|
|
Traf6-p62-aPKC complex, RANK-L stimulated
|
|
|
HTR1A-EDG1 complex
|
|
|
SMN complex (GEMIN5,2,3,4, SMN)
|
|
|
Condensin I complex
|
|
|
CDC2-CCNA2-CDK2 complex
|
|
|
Junb-Sumo1 complex
|
|
|
POLR2A-CCNT1-CDK9-NCL-LEM6-CPSF2 complex
|
|
|
JUND-FOSB-SMAD3-SMAD4 complex
|
|
|
Sulphiredoxin-peroxiredoxin complex
|
|
|
Respiratory chain complex I (gamma subunit) mitochondrial
|
|
|
Respiratory chain complex I (beta subunit) mitochondrial
|
|
|
SNARE complex (STX4, SNAP23, VAMP1)
|
|
|
MURR1-NF(kappa)Bp65-IKBA complex
|
|
|
BRCC complex
|
|
|
Cbl-SLP-76-Grb2 complex, Fc receptor gamma-R1 stimulated
|
|
|
FN1-TGM2 complex
|
|
|
Chromosomal passenger complex CPC (CDCA8, AURKB, BIRC5)
|
|
|
Cdh23-Myo1c complex
|
|
|
L-periaxin-Drp2 complex
|
|
|
BNIP2-ARHGAP8 complex
|
|
|
Respiratory chain complex I (intermediate IV/310kD), mitochondrial
|
|
|
ULBP1-KLRK1-HCST complex
|
|
|
IFNB1-IFNAR1-IFNAR2- complex
|
|
|
PLXNA4-RANBPM complex
|
|
|
ITGA4-ITGB1 complex
|
|
|
TFIID subcomplex
|
|
|
Succinate dehydrogenase complex II (EC 1.3.5.1), mitochondrial
|
|
|
Car-Jam3 complex
|
|
|
Cd247 homodimer complex
|
|
|
B-raf-MAP3K11 complex
|
|
|
Delta1 homodimer complex
|
A protein complex that consists of homodimer of the Notch ligand Delta1.
|
|
FARP2-NRP1-PlexinA2 complex
|
|
|
YY1-Notch1 complex
|
|
|
IL12A-IL12B-IL12RB2 complex
|
|
|
GAIT complex
|
A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP.
|
|
SIN3-HDAC-SAP30-ARID4 complex
|
|
|
ITGAV-ITGB3-PXN-PTK2b complex
|
A protein complex that consists of an alphaV-beta3 integrin complex bound to paxillin and the FAK-related kinase Pyk2.
|
|
CD28-transactivation complex
|
|
|
ITGA6-ITGB1-CD151 complex
|
A protein complex that consists of an alpha6-beta1 integrin complex bound to the tetraspanin CD151.
|
|
ITGA2-ITGB1-CD47 complex
|
A protein complex that consists of an alpha2-beta1 integrin complex bound to the cell surface protein CD47.
|
|
PA28 complex
|
|
|
Complexin complex (STX3, CPLX1, CPLX3)
|
|
|
Polycomb repressive complex 4 (PRC4)
|
|
|
E2F4-p130 complex
|
|
|
pRb2/p130-multimolecular complex (DNMT1, E2F5, SuV39H1, HDAC1, RBL2)
|
|
|
HGF-Met complex
|
|
|
TIP5-DNMT-HDAC1 complex
|
|
|
TERF1 homodimer complex
|
|
|
MOF complex
|
|
|
WINAC complex
|
|
|
RNA polymerase II complex, incomplete (CDK8 complex), chromatin structure modifying
|
|
|
PPP2CA-PPP2R1A-PPP2R3A complex
|
|
|
PU.1-TBP complex
|
|
|
CTF18-RFC subcomplex
|
|
|
PAR-3-PAR-6B-PRKCI complex
|
|
|
(E.F.G) complex
|
A protein complex that comprises three core spliceosomal proteins, designated E, F, and G. Formation of the E.F.G complex is essential but not sufficient for the formation of a stable U1 snRNP complex.
|
|
IKB(epsilon)-RELA-cREL complex
|
|
|
BRCA1-CTIP-ZBRK1 repressor complex
|
|
|
Transcription initiation factor complex (TAF1, TAF5, TAF11, TAF12, TBP)
|
|
|
Cdc2-Ccnb1 complex
|
|
|
SIN3-ING1b complex I
|
|
|
MSL complex
|
A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3.
|
|
MCL1-BAK1 complex
|
|
|
Cd3g-Cd3e complex
|
|
|
SUA1-UBA2 complex
|
|
|
ITGB3-ITGAV-CD47 complex
|
A protein complex that consists of an alphav-beta3 integrin complex bound to CD47 (also known as IAP).
|
|
Nop56p-associated pre-rRNA complex
|
|
|
COG5-COG6-COG7 subcomplex
|
|
|
ZNF198-SUMO1 complex
|
|
|
40S ribosomal subunit, cytoplasmic
|
|
|
NEK2-NEK11 complex
|
|
|
DAXX-AXIN complex
|
|
|
CDCA5-PDS5A-RAD21-SMC1A-PDS5B-SMC3 complex
|
|
|
SHARP-CtBP complex
|
|
|
PRMT5 complex
|
|
|
ITGA7-ITGB1-CD9 complex
|
|
|
ELMO1-DOCK2 complex
|
|
|
MYC-DNMT3A-ZBTB17 complex
|
|
|
MMP-2-claudin-1 complex
|
|
|
HNRPF-HNRPH1 complex
|
|
|
SNARE complex (STX4, VAMP1, VAMP7)
|
|
|
BHC complex
|
|
|
Ryk-Dvl1 complex
|
|
|
Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B)
|
|
|
Aip-Hsp90-Ahr complex
|
|
|
ABI1-WASF2 complex
|
|
|
BRCA1-VCP complex
|
|
|
Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2)
|
|
|
2AR-mGluR2 complex
|
|
|
mTOR-RICTOR complex
|
|
|
Klf5-Pias1 complex
|
|
|
PA28gamma complex
|
|
|
Cohesin complex, incomplete (Smc4, Crest/Ss18I1)
|
|
|
SLC1A2 homotrimer complex
|
|
|
Ubiquitin E3 ligase (CDC34, CUL1, RBX1)
|
|
|
Ksr1-CK2-MEK-14-3-3 complex, PDGF treated
|
|
|
MUS81-CDS1 complex
|
|
|
AGO2-FXR1-TNF(alpha)ARE-RNP complex
|
|
|
ITGAV-ITGB3-SLC3A2 complex
|
A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface antigen CD98.
|
|
SMAD3-HEF1-APC10-CDH1 complex
|
|
|
NgR-TROY-LINGO1 complex
|
|
|
Cd3e homodimer complex
|
|
|
UTX-MLL2/3 complex
|
|
|
Heterotrimeric SKP1-CUL1-ROC1 complex
|
|
|
STAT3 homodimer copmplex
|
|
|
WNK1-SPAk complex
|
|
|
BMP4-BGN complex
|
|
|
FAS-FADD-CASP8 complex
|
|
|
Ng2-Grip1-Glur2 complex
|
|
|
SUMO1-SUA1-UBA2 complex
|
|
|
Mi-2/NuRD-MTA2 complex
|
|
|
LIG1-9-1-1 complex
|
|
|
IL4-IL4R complex
|
|
|
CTF8-DCC1 subcomplex
|
|
|
Guanylyl cyclase, soluble (GUCY1A3, GUCY1B3)
|
|
|
SMN complex (GEMIN2,5, SMN)
|
|
|
Brg1-associated complex I
|
|
|
Hsp110-Hsc70-Hsp25 complex
|
|
|
p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated
|
A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation.
|
|
ITGA9-ITGB1-TNC complex
|
A protein complex that consists of an alpha9-beta1 integrin complex bound to the extracellular matrix protein tenascin.
|
|
Retn homotrimer complex
|
|
|
ELMO1-DOCK1-RAC1 complex
|
|
|
Htt-Dctn1-Hap1 complex
|
|
|
SNARE complex (VAMP2, SNAP25, STX1a, CPLX3, CPLX4)
|
|
|
p19-Cdk4 complex
|
|
|
THRB-RXRB complex
|
|
|
RC complex (Replication competent complex)
|
|
|
TCL1(trimer)-AKT2 complex
|
|
|
Sarcoglycan-sarcospan complex SG-SPN
|
|
|
SNARE complex (STX11, VAMP2, SNAP23)
|
|
|
RIAM-Rap1-GTP complex
|
|
|
Dysferlin-affixin complex
|
|
|
Gata1-Gfi1b complex
|
|
|
Brg1-associated complex II
|
|
|
SERPINA3-CTSG complex
|
|
|
RET-Rai complex
|
|
|
Mss4-Itga3 complex
|
|
|
ERG-JUN-FOS DNA-protein complex
|
|
|
TFIIIC containing-TOP1-SUB1 complex
|
|
|
55S ribosome, mitochondrial
|
A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes.
|
|
Rag1-Rag2 protein-DNA complex
|
|
|
Ubiquitin E3 ligase (FBXO31, SKP1A, CUL1, RBX1)
|
|
|
Myod1-Tcf3 complex
|
|
|
Tankyrin 1-tankyrin 2-TRF1 complex
|
|
|
Cd2ap-Synpo complex
|
|
|
RBP-Jkappa-RING1-KyoT2 complex
|
|
|
TRIB3-DDIT3 complex
|
|
|
Eya1/3-Dach1/2-Six1 complex
|
|
|
TFIID-beta complex
|
|
|
BRCA1-RAD50-MRE11-NBS1 complex
|
|
|
Ecsit complex (ECSIT, MT-CO2, NDUFA1, MT-ND1, TRAF6, NDUFAF1)
|
|
|
ITGA2-ITGB1-COL6A3 complex
|
A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.
|
|
LIN2-LIN7-SAP97-MINT1 complex
|
|
|
HDAC1-associated protein complex
|
|
|
Mitotic 14S cohesin 2 complex
|
|
|
Smad2-Smad4 complex
|
|
|
TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1)
|
|
|
PINK1-MIRO2-Milton complex
|
|
|
Emerin complex 25
|
|
|
Emerin complex 24
|
|
|
Ubiquitin-protein-ligase (UBE2N, UBE2V2/MMS2)
|
|
|
E2F-6 complex
|
|
|
NRP1-VEGFC complex, heparin dependent
|
|
|
JBP1-pICln complex
|
|
|
Kinase maturation complex 1
|
|
|
Kinase maturation complex 2
|
|
|
Cleavage and polyadenylation factor (CPSF)
|
|
|
PLC-gamma-1-SLP-76-SOS1-LAT complex
|
|
|
RalBP1-CDC2-CCNB1 complex
|
|
|
TEAD2-multiprotein complex
|
A protein complex that consists of the DNA binding protein TEAD-2 bound to 12 other polypeptides including the transcriptional coactivator YAP, the multi-PDZ domain protein MPDZ (also called MUPP1), a 14-3-3 domain protein, and others.
|
|
PLC-gamma-2-LAT complex
|
|
|
p19-Cdk6 complex
|
|
|
TF-FVIIa-FXa-TFPI complex
|
|
|
AK2-FADD-caspase-10 (AFAC10) complex
|
|
|
SORT1-NGFR-NGFB complex
|
|
|
GIPC1-NTRK1-RGS19 complex
|
|
|
ITGB1-NRP1 complex
|
|
|
CyclinA2-Cdk2 complex
|
A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
|
|
Frs2-Grb2-Shp2 complex, FGF stimulated
|
|
|
ITGAV-ITGB3-LAMA4 complex
|
A protein complex that consists of an alphaV-beta3 integrin complex bound to laminin alpha-4.
|
|
CTF18-cohesion-RFC complex
|
|
|
Acinar cell-specific C complex
|
A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes.
|
|
SMN1-SIP1-SNRP complex
|
|
|
PLC-gamma-1-LAT-c-CBL complex, OKT3 stimulated
|
|
|
Angiomotin isoform p80-Angiostatin complex
|
|
|
CAND1-CUL2-RBX1 complex
|
|
|
InsP3R1-HAP1A-Htt complex
|
|
|
Lymphotoxin beta receptor complex
|
|
|
TIM (TIMM23, TIMM50) complex, mitochondrial
|
|
|
GluR6a-GluR6b-KA2 complex
|
|
|
DNA ligase IV-condensin complex
|
|
|
PAR-3-VE-cadherin-beta-catenin complex
|
|
|
Trpc1-dystrophin-alpha1-syntrophin complex
|
|
|
Cohesin complex, incomplete (Stag3, Crest/Ss18I1)
|
|
|
ITGA2B-ITGB3-FN1-TGM2 complex
|
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to fibronectin and tissue transglutaminase.
|
|
RSmad complex
|
|
|
RAD17-RFC-9-1-1 checkpoint supercomplex
|
|
|
Tetrameric COG subcomplex
|
|
|
USP1-UAF1 complex
|
|
|
RC complex during S-phase of cell cycle
|
|
|
RAD50-BRCA1 complex
|
|
|
SNX complex (SNX1, SNX6)
|
|
|
Integrator complex
|
A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II.
|
|
PCNA-p21 complex
|
A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication.
|
|
CRLR-RAMP1 complex
|
|
|
LINC core complex
|
|
|
MDC1-p53BP1-SMC1 complex
|
|
|
REL-MAP3K8-RELA-TNIP2-PAPOLA complex
|
|
|
PU.1-Sin3A-Hdac-MeCP2 complex
|
|
|
Bmi1-Mel18-Mph1-M33 polycomb repressor complex
|
|
|
RAB9-TIP47-MPRI complex
|
|
|
TGF-beta receptor II-TGF-beta3 complex
|
|
|
TCL1(homotrimer) complex
|
|
|
RICH1-PAR3-aPKC polarity complex
|
|
|
F1F0-ATP synthase (EC 3.6.3.14), mitochondrial
|
|
|
IL12A-IL12B complex
|
|
|
p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex
|
|
|
MSH2-MSH6-PMS2-MLH1 complex
|
|
|
Nup 107-160 subcomplex
|
|
|
FHL2-ACT complex
|
|
|
Multicomponent signaling complex, anti-CD40 stimulated (Birc2, Birc3, Cd40, Ikbkg, Map2k4, Map2k7, Map3k1, Traf2, Ube2n)
|
|
|
DNA ligase IV-XRCC4-XLF complex
|
|
|
FHL2-FHL3 complex
|
|
|
Tle3-Aes complex
|
A transcriptional repressor complex that consists of a heterodimer of the proteins Tle3 (also known as Grg3b) and Aes (Grg5), which are homologs of the Drosophila groucho gene product.
|
|
RFC2-5 subcomplex
|
|
|
IKBKG-CHUK complex
|
|
|
Cytosolic multicomponent signaling complex, anti-CD40 stimulated, (Ikbkg, Map3k1, Traf2, Ube2n)
|
|
|
Pcdhga1-Pcdhgb2 complex
|
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane.
|
|
ITGA4-ITGB1-CD63 complex
|
A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD63, a member of the tetraspan family.
|
|
Cohesin complex, incomplete (Stag3, Scp1, Ss181)
|
|
|
Ccd1-Dvl2-Rac complex
|
|
|
TCF4-CTNNB1-SUMO1-EP300-HADAC6 complex
|
|
|
Ksr1-Mek-Braf-Erk complex, EGF induced
|
|
|
NCOR1 complex
|
|
|
Snurportin-CRM1-RanGTP complex
|
|
|
WICH complex
|
An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and WSTF (Williams Syndrome Transcription Factor). WICH plays roles in regulation of RNAP I and III transcription and in DNA replication and repair.
|
|
G protein complex (HDAC4, GNB1, GNG2)
|
|
|
CSK-GAP-A.p62 complex
|
A protein complex that contains the protein-tyrosine kinase CSK and the GTPase-activating protein (GAP)-associated p62 (GAP-A.p62); may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation.
|
|
CyclinD1-CDK4-CDK6 complex
|
|
|
p33ING1b-HDAC1 complex
|
|
|
Sh3kbp1-Cblb-Pdgfrb complex
|
|
|
SMN complex (GEMIN6,7, UNRIP), SMN-independent intermediate
|
|
|
Cell division cycle complex (CDC27, CDC16, ANAPC7)
|
|
|
Ubiquitin E3 ligase (SKP1A, FBXW2, CUL1)
|
|
|
AFF1-MLLT1-CBX8 complex
|
|
|
CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)
|
A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein.
|
|
Postsplicing complex
|
|
|
ITGA11-ITGB1-COL1A1 complex
|
A protein complex that consists of an alpha11-beta1 integrin complex bound to a type I collagen.
|
|
Ubiquitin E3 ligase (WSB1, TCEB1, TCEB2, CUL5, RBX1)
|
|
|
HDAC2-asscociated core complex
|
|
|
Heterotrimeric complex (CCNT1, CDK9, GRN)
|
|
|
CRKL-WIPF1-WAS complex
|
|
|
TGF-beta receptor
|
|
|
SMAD3-SMAD4-FOXO1 complex
|
|
|
Kpna2-Kpnb1 complex
|
|
|
APC-DLG4 complex
|
|
|
CAND1-CUL4A-RBX1 complex
|
|
|
TGF-beta receptor I-Axin-SMAD3 complex
|
|
|
RAF1-RAS complex, EGF induced
|
|
|
Cdk5-c-Abl-Cables complex
|
|
|
SWAP complex
|
|
|
Ubiquitin E3 ligase (SKP1A, SKP2, CUL1)
|
|
|
R/M complex (RAD50-MRE11 complex)
|
|
|
Large Drosha complex
|
|
|
Sec6/8 exocyst complex
|
|
|
Gata1-Fog1 complex
|
|
|
MeCP2-SIN3A-HDAC complex
|
|
|
SMAD3-VDR complex
|
|
|
ESCRT-I complex
|
An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.
|
|
Epo-R-PLC-gamma-TRPC2 complex
|
|
|
MAD1-mSin3A-HDAC2 complex
|
|
|
Bipartite complex (TFC4, CTNNB1)
|
|
|
HTR1A homodimer complex
|
|
|
Cytochrome c oxidase (EC 1.9.3.1), mitochondrial
|
|
|
DNA synthesome core complex
|
|
|
hs4 enhancer complex (faster migrating complex)
|
|
|
NRP1-VEGFD complex, heparin dependent
|
|
|
CREBBP-SMAD2 hexameric complex
|
|
|
TEAD1-YAP DNA-protein complex
|
|
|
Shc-Grb2-mSos1 complex, EGF stimulated
|
A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
|
|
TALL1 homo-oligomer complex
|
|
|
IL-12 heterodimer complex
|
|
|
BKCA-beta2AR-AKAP79 signaling complex
|
|
|
Notch1-fraction 30 complex
|
|
|
Ship-Shc complex, IL-3 stimulated
|
|
|
Ecsit complex (Ecsit2-Smad1)
|
|
|
MKK4-ARRB2-ASK1 complex
|
|
|
TRAF2-MALT1 complex
|
|
|
Ubiquitin E3 ligase (Fbxo15, Cul1, Skp1a)
|
|
|
KSR1 homooligomer complex
|
|
|
TRF-Rap1 complex I, 2MD
|
|
|
FACT complex, UV-activated
|
|
|
BRD4-P-TEFb complex
|
|
|
RICH1/AMOT polarity complex, Flag-Amot precipitated
|
|
|
Emerin complex 32
|
|
|
SNARE complex (HGS, SNAP25, STX13)
|
|
|
Trip(Br1)-Dp1-E2F1 complex
|
|
|
MT1-MMP-claudin-1 complex
|
|
|
WCRF complex
|
|
|
Kir4.1-dystrophin complex, whole brain lysate
|
|
|
CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1)
|
|
|
TAJ-NgR1-LINGO-1 signaling complex
|
|
|
NCOR-SIN3-HDAC1 complex
|
|
|
CALM1-FKBP38-BCL2 complex
|
|
|
FHL2 homodimer complex
|
|
|
GPR56-CD81-Galphaq/11-Gbeta complex
|
|
|
CREBBP-SMAD3-SMAD4 pentameric complex
|
|
|
PCNA-PAF complex
|
|
|
PlexinA1-NRP1-SEMA3A complex
|
|
|
Srf-myogenin-E12 complex
|
A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes.
|
|
Menin-associated histone methyltransferase complex
|
|
|
MAD2-CDC20 complex
|
|
|
Farnesyltransferase
|
|
|
9-1-1 complex
|
|
|
DNA-PK-Ku complex
|
|
|
Mis12 centromere complex
|
|
|
DNAJB2-HSPA8-PSMA3 complex
|
|
|
SCF subcomplex (WEE1, SKP2, BTRC)
|
|
|
EED-EZH-YY1 polycomb complex
|
|
|
BRCA1-IRIS-pre-replication complex
|
|
|
PAR3-PAR6-PALS1 complex
|
|
|
BMI1-HPH1-HPH2 complex
|
|
|
ADRB2 homodimer complex
|
|
|
c-MYC-ATPase-helicase complex
|
|
|
20S methylosome-SmD complex
|
|
|
Cask-Dlg1 complex
|
|
|
CRKL-PDGFRA-CRK-RAPGEF1 complex
|
|
|
TEAD4-YAP DNA-protein complex
|
|
|
Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1)
|
|
|
H2AX complex II
|
|
|
PABPC1-HSPA8-HNRPD-EIF4G1 complex
|
|
|
Artemis-DNA-PK complex
|
|
|
SNARE complex (VAMP4, STX6, STX16, VTI1a, VTI1b)
|
|
|
MIRO2-Milton complex
|
|
|
PTF1-bHLH complex
|
|
|
Cofilin-actin-CAP1 complex
|
|
|
PGRMC1-SCAP complex
|
|
|
ITGA6-ITGB4-FYN complex
|
A protein complex that consists of an alpha6-beta4 integrin complex bound to the Src family tyrosine kinase Fyn.
|
|
ABI1-WASL complex
|
|
|
RBPJ-NotchIC-Mastermind complex
|
|
|
TRF1 telomere length regulation complex
|
|
|
RNA pol II containing coactivator complex Tat-SF
|
|
|
Heterodimer complex (CDK9, IL6ST)
|
|
|
SNX complex (SNX1a, SNX2, SNX4, TFRC)
|
|
|
VAM1-VELI1 complex
|
|
|
Gata1-Ldb1-Tal1 complex
|
|
|
BRCA1-CtIP-CtBP complex
|
|
|
PLXNA2-RANBPM complex
|
|
|
Cohesin complex, incomplete (Smc1b, Sycp1, Crest/Ss18I1)
|
|
|
ITGAV-ITGB3-THBS1 complex
|
A protein complex that consists of an alphav-beta3 integrin complex bound to thrombospondin.
|
|
Stat3-Crebbp complex
|
|
|
TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex
|
A protein complex that is formed by the association of a ligand-bound TGF-beta type II receptor dimer with a TGF-beta type I receptor dimer.
|
|
G protein complex (CACNA1A, GNB1, GNG2)
|
|
|
G protein complex (PTHR1, GNB1, GNG2)
|
|
|
MRN complex (MRE11-RAD50-NBN complex)
|
|
|
Prolactin (PRL) - PRL receptor (PRLR) complex
|
|
|
RAPTOR-mTOR complex
|
|
|
AIF-CYPA-DNA complex
|
|
|
CRM1-RAN-PHAX-CBC complex (cap binding complex)
|
|
|
TFIID complex
|
|
|
SNARE complex (SNAP25, VAMP3, VAMP2, NAPB, STX13)
|
|
|
Survivin homodimer complex
|
|
|
Catenin (alpha) - catenin (beta) complex
|
|
|
TGM2-HD complex
|
|
|
Exon junction complex
|
|
|
ITGAV-ITGB6-TGFB3 complex
|
|
|
COX1 homodimer complex
|
|
|
MSH2-MSH6-PMS1-MLH1 complex
|
|
|
GRB2-SHP-2 complex, PDGF stimulated
|
A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway.
|
|
hSIR2-p53 complex
|
|
|
DGCR8-ILF3 complex
|
|
|
ASCOM complex
|
|
|
Ternary complex (LRRC7, CAMK2a, ACTN4)
|
|
|
Respiratory chain complex I (incomplete intermediate), mitochondrial
|
|
|
SMRT-SKIP-CBF1 complex
|
|
|
CCNB1-CDC2 complex
|
|
|
DCP1A-DCP2 Decapping complex
|
|
|
Ccna2-Cdk2 complex
|
|
|
URI complex (Unconventional prefoldin RPB5 Interactor)
|
|
|
SMAD3-SMAD4-FOXO3 complex
|
|
|
CHUK-IKBKB-IKBKG complex
|
|
|
COG1-COG8-COG2-COG3-COG4 subcomplex
|
|
|
Ccd1-Axin complex
|
|
|
p33ING1b-PCNA complex
|
|
|
Neddylin ligase (FBXO11, SKP1, CUL1, RBX1)
|
|
|
ClpX complex, hexameric
|
|
|
Il3rb1-Shc-Ship complex, IL-3 stimulated
|
|
|
IKKB-NIK complex
|
|
|
Abcg5-Abcg1 complex
|
|
|
Ternary complex (Abl1, Dok1, Nck1)
|
|
|
TNF-alpha/NF-kappa B signaling complex 8
|
|
|
TNF-alpha/NF-kappa B signaling complex 9
|
|
|
HCF-1 complex
|
|
|
Casein kinase II-HMG1 complex
|
|
|
TRAF6-MALT1 complex
|
|
|
TNF-alpha/NF-kappa B signaling complex 7
|
|
|
TNF-alpha/NF-kappa B signaling complex 5
|
|
|
RB1-HDAC1-BRG1 complex
|
|
|
BP-SMAD complex
|
|
|
DNMT3B-DNMT3L complex
|
|
|
eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7)
|
|
|
LRP-1-Alpha-2-M-annexin VI complex
|
|
|
BAR-BCL2-CASP8 complex
|
|
|
ITGAV-ITGB5-CYR61 complex
|
|
|
CNK1 homodimer complex
|
|
|
Whrn homodimer complex
|
|
|
TLE2 homodimer complex
|
|
|
PLC-gamma-2-Syk-LAT-FcR-gamma complex
|
|
|
Emerin-actin-NMI complex
|
|
|
SLP-76-PLC-gamma-1-VAV complex, alpha-TCR stimulated
|
|
|
RNF20-RNF40-UbE2E1 complex
|
|
|
HSP90-CDC37-LRRK2 complex
|
|
|
EPO-EPOR complex
|
|
|
TIP49-TIP48-BAF53 complex
|
|
|
mPar6c-Mlgl-aPKCz complex
|
|
|
EXO1-MLH1-PMS2 complex
|
|
|
Smad1-Notch1-p300-Pcaf complex
|
|
|
Lingo1-Rtn4r-Tnfrsf19 complex
|
|
|
SMRT complex
|
|
|
p56(LCK)-CAML complex
|
|
|
CD20-LCK-LYN-FYN-p75/80 complex, (Raji human B cell line)
|
|
|
DJ-1-SNCA complex, high molecular weight complex
|
|
|
DAXX-DNMT1-DMAP1 complex
|
|
|
CDK8-CyclinC-Mediator complex
|
|
|
Rb-HDAC1 complex
|
|
|
26S proteasome
|
|
|
SMAD6-HOXA9 complex
|
|
|
MondoA-Mlx complex
|
|
|
Dysbindin-pallidin-muted-beta-dystrobrevin complex
|
|
|
CDC2-PCNA-CCNB1-GADD45B complex
|
|
|
Meiotic cohesin complex
|
A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.
|
|
Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant)
|
A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein.
|
|
Transcription initiation factor complex (TAF5, TAF6, TAF9, TAF11, TBP)
|
|
|
INO80 chromatin remodeling complex
|
A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity.
|
|
Fertilin complex (Adam1a, Adam2)
|
|
|
BAD-BCL2xL complex
|
|
|
TRRAP-BAF53-HAT complex
|
|
|
Skeletal muscle sarcoglycan complex SGC, beta-gamma-delta-zeta
|
|
|
Ubiquitin E3 ligase (Fbxo2, Skp1a, Cul1, Rbx1)
|
|
|
SNARE complex (STX4, SNAP23, VAMP2)
|
|
|
OCT1-OBF1-DNA-TLE1 complex
|
|
|
Ku-ORC complex
|
|
|
Sam68-p120GAP complex
|
|
|
BCR-ABL (p210 fusion protein)-GRB2 complex
|
|
|
OGT-TRAK1-TRAK2 complex
|
|
|
RAD9-RAD1-HUS1-APE1 complex
|
|
|
YWHAQ-CALM1-CABIN1 complex
|
|
|
ITGB6-FYN-FN1 complex
|
|
|
RalBP1-CCNB1-AP2A-NUMB-EPN1 complex
|
|
|
Toposome
|
|
|
HuCHRAC complex
|
|
|
Rab11Fip2-Ap2a complex
|
|
|
B23-NPM3 complex
|
|
|
ITGA9-ITGB1-SPP1 complex
|
A protein complex that consists of an alpha9-beta1 integrin complex bound to osteopontin.
|
|
IKBKG homotrimer complex
|
|
|
Ubiquitin E3 ligase (SKP1A, FBXW8, CUL7, RBX1)
|
|
|
CCNB2-CDC2 complex
|
|
|
CCT micro-complex
|
|
|
CNTF-CNTFR-gp130-LIFR complex
|
|
|
EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C)
|
|
|
(C-CFTR)2-NHERF-ezrin complex
|
|
|
6S methyltransferase complex
|
|
|
BCL6-ZBTB17 complex
|
|
|
BLM-RAD51L3-XRCC2 complex
|
|
|
ITGA2-ITGB1-CHAD complex
|
A protein complex that consists of an alpha2-beta1 integrin complex bound to the cartilage matrix protein chondroadherin.
|
|
NGF-TrkA complex
|
|
|
Rb1-Runx2 complex
|
|
|
Death-inducing signaling complex DISC (type I cells associated), stimulated
|
|
|
Casein kinase II (beta-dimer, alpha-dimer)
|
|
|
MBD1-Suv39h1-HP1 complex
|
|
|
FACT complex
|
An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer.
|
|
Succinyl-CoA synthetase, GDP-forming
|
A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP.
|
|
HTR1A-EDG3 complex
|
|
|
CDC2-CCNB1-CCNF complex
|
|
|
DNA synthesome complex (13 subunits)
|
|
|
C/EBPalpha-HNF6 complex
|
|
|
COG1-COG8 subcomplex
|
|
|
HES1 promoter-Notch enhancer complex
|
|
|
HUIC complex
|
|
|
CoREST-HDAC2 complex
|
|
|
EIF3 core complex (EIF3A, EIF3B, EIF3G, EIF3I)
|
|
|
GAA1-GPI8-PIGT-PIG-PIGS complex
|
|
|
Eps15-stonin2 complex
|
|
|
Pax3-Lef1-Tle4 complex
|
|
|
RANBP1-RAN-KPNB1 complex
|
|
|
Kir4.1-alpha-1-syntrophin complex, cortical astrocytes
|
|
|
ClpXP complex
|
|
|
28S ribosomal subunit, mitochondrial
|
|
|
Ksr1-CK2 complex
|
|
|
Bcl2 homodimer complex
|
|
|
HTR1A-HTR1B complex
|
|
|
CIN85-BLNK complex
|
|
|
Caveolin-1 homodimer complex
|
|
|
mTOR-RAPTOR complex
|
|
|
PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated
|
A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA), phospholipase C-gamma-1 (PLC-gamma-1), phosphatidylinositol 3-kinase (PI3K) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.
|
|
Interferon-stimulated gene factor 3 transcription complex ISGF3
|
|
|
MSH2-MSH6 complex
|
|
|
Ryk-Wnt3a complex
|
|
|
Ikaros-NuRD complex
|
|
|
Dok1-Map4k4-Nck1-Rasa1 complex
|
|
|
ING1-PCNA complex
|
|
|
pRB-E2F-1 complex
|
|
|
ITGA2B-ITGB3 complex
|
|
|
EPOR receptor complex
|
|
|
Ubiquitin E3 ligase (NFKBIA, BTRC, CUL1, SKP1A)
|
|
|
TIM50a-SMN1 complex
|
|
|
BUB1-BUB3 complex
|
Protein complex that associates with the kinetochores.
|
|
MutS-alpha-histone H4 complex
|
|
|
ORC complex (origin recognition complex)
|
|
|
Nfkb1-Rela complex
|
|
|
Chromosomal passenger complex CPC (INCENP, BIRC5, AURKB)
|
|
|
ILF3-XPO5 complex
|
|
|
Hip1R-cortactin complex
|
|
|
TRIKA2 protein kinase complex (TAK1, TAB1, TAB2)
|
|
|
APP-TOMM40 complex
|
|
|
SHARP-CtBP1-CtIP-RBP-Jkappa corepressor complex
|
|
|
RNA polymerase II complex, incomplete (CBP, RPBI, PCAF, BAF47), chromatin structure modifying
|
|
|
ITGA9-ITGB1-FIGF complex
|
A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor D.
|
|
RAF1-MAP2K1-YWHAE complex
|
|
|
Ubiquitin E3 ligase (H2AFY, SPOP, CUL3)
|
|
|
ITGA4-ITGB1-THBS2 complex
|
A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-2.
|
|
IPO13-RAN-EIF1AX complex
|
|
|
60S APC containing complex
|
|
|
Fgf2-Rsk2 complex
|
|
|
Scrib-APC-beta-catenin complex
|
A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation.
|
|
Polycomb repressive complex 3 (PRC3)
|
|
|
BARD1-BRCA1-CSTF complex
|
|
|
SMRT core complex
|
|
|
ALL-1 supercomplex
|
|
|
Itga9-Itgb1-Thbs1 complex
|
A protein complex that consists of an alpha9-beta1 integrin complex bound to thrombospondin-1.
|
|
ARC92-Mediator complex
|
|
|
C complex spliceosome
|
|
|
TIM (TIMM17ab, TIMM23, TIMM44) complex, mitochondrial
|
|
|
BASC (Ab 80) complex (BRCA1-associated genome surveillance complex)
|
|
|
p23 protein complex
|
|
|
CACY homodimer complex
|
|
|
PU.1-associated protein complex
|
|
|
COP9 signalosome complex
|
|
|
Kif13a-AP1 complex
|
|
|
ITGAV-ITGB5-PLAUR complex
|
|
|
FCP1-associated protein complex
|
|
|
Mlx-Mad1 complex
|
|
|
FHL3 homodimer complex
|
|
|
LEPR homodimer complex
|
|
|
tRNA splicing endonuclease
|
|
|
PCNA-MLH1-PMS1 complex
|
|
|
BANF1 homodimer protein
|
|
|
BCL6-HDAC4 complex
|
|
|
NRP2-VEGFC complex
|
|
|
MSH2-MSH3 complex
|
|
|
MCM2-MCM4-MCM6-MCM7 complex
|
|
|
RNA-induced silencing complex, RISC
|
|
|
Par-3-p75NTR complex
|
|
|
KSR1-RAF1-MEK complex
|
|
|
snRNP-free U1A (SF-A) complex
|
|
|
HTR1A-HTR1D complex
|
|
|
PAR-6-PAR-3-VE-cadherin complex, endothelial
|
|
|
Ubiquitin E3 ligase (ASB7, TCEB1, TCEB2, CUL5, RNF7)
|
|
|
SMAD3-SMAD4-FOXO3-FOXG1 complex
|
|
|
ARD1-NATH complex
|
|
|
Isl1-Jak1-Stat3 complex
|
|
|
Endoglin homodimer complex
|
|
|
SHP-NR5A2 complex
|
|
|
TRAF2-TRADD complex
|
|
|
ITGA4-ITGB1-CD47 complex
|
|
|
Pkd2-Fpc-Kif3b complex
|
|
|
GR-hnRNP U complex
|
|
|
SETDB1-containing HMTase complex
|
|
|
HDAC4-ERK2 complex
|
|
|
Exon junction complex (EIF4A3-MLN51-UPF3B-MAGOH-Y14)
|
|
|
Histone H3.3 complex
|
|
|
Multisubunit ACTR coactivator complex
|
|
|
Skeletal muscle sarcoglycan complex SGC, epsilon-beta-gamma-delta
|
|
|
Ubiquitin E3 ligase (DDB1, CUL4A, RBX1)
|
|
|
ITGA6-ITGB4-CD151 complex
|
A protein complex that consists of an alpha6-beta4 integrin complex bound to the tetraspanin CD151.
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SKI-SMAD3 hexameric complex
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Ripk2-Nod2 complex
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EB1-APC-mDia1 complex
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Class C Vps complex (VPS11, VPS18, VPS16)
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VPS35-VPS29-VPS26A complex
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RFC core complex
|
A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37.
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Ubiquitin E3 ligase (SIAH1, SIP, SKP1A, TBL1X)
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CAP(C)-CAP(E) complex
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DNA-PK-Ku-eIF2-NF90-NF45 complex
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Bash-Bnas2/Cmtm3-Btk-Erk2 complex
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LAT-GRB2 complex, Fyn-mLck(KA) or Syk kinase activated
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VHL-VDU1-TCEB1-TCEB2 complex
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TIF-IB complex
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ITAGV-ITGB3-F11R complex
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Mad-Max-mSin3a complex
|
A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3A, a homolog of the yeast Sin3p.
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Ternary complex (GATA4, SRF, MYOCD)
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RANBPM-Muskelin-TWA1-HSMpp8 complex
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Smcb-Smcd-PW29 complex
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DNA-PK-Ku antigen complex
|
A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku.
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PRNP-ApolopoproteinE3 complex
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ITGA2b-ITGB3-CD47-FAK complex
|
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK.
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Ksr1-PP2A holoenzyme complex (Ppp2r1a, Ppp2r2b, Ppp2ca), PDGF stimulated
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Daxx-Axin-p53 complex
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NCR3-CD247 complex
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Ets2-Smarca4-Smarcb1-Smarce1 complex
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RNA polymerase II complex (RPB1, RAP74, CDK8, CYCC, SRB7, BAF190, BAF47), chromatin structure modifying
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ITGA9-ITGB1-ADAM15 complex
|
A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM15.
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TCL1(trimer)-AKT1 complex
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SNARE complex (Stx4, Vamp2, Snap23)
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MRIT complex
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H2AX complex I
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mSin3A-HDAC1-HDAC2 complex
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SNARE complex (VAMP3, VAMP4, STX16)
|
A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof).
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PYR complex
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EIF3 complex (EIF3B, EIF3J, EIF3I)
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GNA14-p115RhoGEF complex
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ITGA11-ITGB1 complex
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SF3A1-SF3A2-SF3A3 complex
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MCM4-MCM6-MCM7 complex
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Mitotic checkpoint complex (MCC)
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SMAD3-SKI complex
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MCM8-ORC2-CDC6 complex
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EED-EZH2 complex
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CTFC-TAF1 complex
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DNA double-strand break end-joining complex
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p50-p65 NF(kappa)B complex
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Channel complex TRPM6-TRPM7
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Anti-HDAC2 complex
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Mediator complex 2
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SVIP-p97/VCP-DERL1 complex
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ATM homodimer complex
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ITGAV-ITGB8-MMP14-TGFB1 complex
|
A protein complex that consists of an alphaV-beta8 integrin complex bound to matrix metalloproteinase 14 and transforming growth factor beta-1 (TGFbeta-1).
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Tripeptidyl peptidase
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DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex
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TRPV5-S100A10-annexin 2 complex
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OCT4-SOX2 DNA-protein complex
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Sarcoglycan-sarcospan-complex SG-SPN
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G protein complex (GNG2, GNB2L1, RAF1)
|
A protein complex formed by the association of the serine-threonine protein kinase Raf-1 with the beta and gamma subunits of a heterotrimeric G protein.
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Axin-SMAD3 complex
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Cd3e-Nck1-Mink1 complex
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Egfr-Grb2-mSos1 complex, EGF stimulated
|
A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
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SCRIB-LGL2 complex
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SHARP-CtBP1-CtIP complex
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ITGAE-ITGB7-CDH1 complex
|
A protein complex that consists of an alphaE-beta7 integrin complex bound to E-cadherin.
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PCNA-MutS-alpha-MutL-alpha-DNA complex
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Gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)
|
A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein.
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SH3KBP1-CBLB-EGFR complex
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Splicing-associated factors complex
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HD-RAB8A-OPTN complex
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Protein-sorting complex (Stam2, Hgs, Eps15)
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TFIIH transcription factor core complex
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Tis7-Sin3-Hdac1-Ncor1-Sap30 complex
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Ecsit complex (ECSIT, NDUFS3, NDUFAF1)
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SNARE complex (VAMP3, VAMP4, VAMP8, STX6)
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Muscle-derived dystrobrevin-syntrophin complex
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BRCA1 B complex
|
A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites.
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G protein complex (Gngt2, Kcnj6, Gnb1)
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Septin complex
|
A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric.
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CEBPE-E2F1-RB1 complex
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DNA ligase IV-XRCC4 complex (LX complex)
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LCK-SLP76-PLC-gamma-1-LAT complex, pervanadate-activated
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ELK1-SRF-ELK3 complex
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Ets2-Ini1-Smarce1-Smarca4 complex
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Spliceosome
|
Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron.
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SRC-1 complex
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LINGO-1-Nogo-66-p75 signaling complex
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Cyclin D1-associated protein complex
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p14-Mp1-ERK2 complex
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Stat5a-Jak2 complex
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ITGAV-ITGB3-CD47-FCER2 complex
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Car-Lnx2 complex
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E2F5-RB2-DP1 complex
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Fertilin complex (Adam1b, Adam2)
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Arnt-Sim2 complex
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DIPA-MCRS1 complex
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Polycomb repressive complex 1 (PRC1, hPRC-H)
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Pre-initiation complex (PIC)
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SNARE complex (STX6, SNAP23)
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Ternary COG subcomplex
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Lef1-Tle1-Ctnnb1 complex
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DNA ligase IV-XRCC1 complex
|
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WRN-Ku70-Ku80-PARP1 complex
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CRKII-C3G complex
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PPP2CA-PPP2R1A complex
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p300/CBP-PCAF-MyoD complex
|
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SMN-PolII-RHA complex
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TEAD3-YAP DNA-protein complex
|
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Gata1-Fog1-MeCP1 complex
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TLE1 homodimer complex
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BLOC-2 (biogenesis of lysosome-related organelles complex 2)
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CoREST-HDAC complex
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pRb2/p130-multimolecular complex (DNMT1, E2F4, SuV39H1, HDAC1, RBL2)
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Psd3-Actn1 complex
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Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1)
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Wave-2 complex (Rac-activated)
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Guanylyl cyclase, soluble (GUCY1A2, GUCY1B3)
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AOF2-AR complex
|
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Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced
|
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c-Src-Muc1 complex
|
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TGM2-HD-CALM1 complex
|
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nKHC-KLC1-KLC2 kinesin complex
|
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LIN9-BMYB complex
|
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9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex
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NMI-POLR1B-RRN3 complex
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17S U2 snRNP
|
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CRSP complex
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Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1)
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cMYC-ATPase-helicase complex
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NOS3-CAV1-NOSTRIN complex
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STAT5B homodimer complex
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BRCA1-BARD1-BACH1-DNA damage complex I
|
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DAB complex
|
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SWI-SNF chromatin remodeling-related-BRCA1 complex
|
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Dvl2-Rac complex
|
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Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1)
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BRAF-MAP2K1-MAP2K2-YWHAE complex
|
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G protein complex (BTK, GNG1, GNG2)
|
A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein.
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SNX complex (SNX1a, SNX2, SNX4, LEPR)
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CNK1-SRC-RAF1 complex
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TRAF6-TAK1 complex
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Histone H3.1 complex
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RPA-MSH4-BLM complex
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CHL2-BMP2 complex
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NuMA-LGN-G-alpha-i-1 complex
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eNOS-HSP90 complex, VEGF induced
|
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ESCRT-III complex
|
An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes.
|
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Ecsit complex (Ecsit2-Smad4)
|
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MAD-MAX complex
|
A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max.
|
|
C1D homodimer protein
|
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ITGA3-ITGB1 complex
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p300-MDM2-p53 protein complex
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FHL2-p53-HIPK2 complex
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Cdk5/p35 complex (Cdk5-Cdk5r1 complex)
|
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Sarcoglycan-sarcospan-dystroglycan complex
|
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PTGS2 homodimer complex
|
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NuRD.1 complex
|
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FARP2-NRP1-PlexinA4 complex
|
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Kif17-Lin10 complex
|
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IL-12 subunit p40 homodimer complex
|
|
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Sin3-Hdac1-Sds3 complex
|
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Sycp1-Syce1-Syce2 complex
|
|
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Smrt-Sin3A-Hdac7 complex
|
|
|
Prune-GSK3beta complex
|
|
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Cd3g-Cd3e-Cd247-Canx complex
|
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|
Ksr1 complex (Ksr1, Mek, 14-3-3), unstimulated
|
|
|
SRCAP-associated chromatin remodeling complex
|
|
|
Vigilin-DNA-PK-Ku antigen complex
|
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hASC-1 complex
|
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SNARE complex (VAMP3, STX6, VTI1A)
|
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|
CIN85-c-CBL complex
|
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|
DICER1-NCOA6-AGO2 complex
|
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Parvulin-associated pre-rRNP complex
|
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|
Dolichol-phosphate mannose (DPM) synthase
|
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|
SIRT1 homotrimer complex
|
|
|
NDC80 kinetochore complex
|
|
|
E-box sequence-binding complex
|
|
|
Cleavage stimulation factor
|
|
|
BRG1-associated complex
|
|
|
CTF18-cohesion-RFC-POLH complex
|
|
|
NCOR-SIN3-HDAC-HESX1 complex
|
|
|
HTR1D homodimer complex
|
|
|
Rab27a-Mlph-Myo5a complex
|
|
|
CRMP-MICAL-PlexinA1 complex, induced by SEMA3A
|
|
|
AXIN-MEKK4-CCD1 complex
|
|
|
IKKA-IKKB complex
|
|
|
CDH1-SKP2 complex
|
|
|
Smarcb1/Ini1-Smarca2-Mecp2 complex
|
|
|
PTF1 complex (Ptf1a, Tcf12, Rbpj)
|
|
|
AXIN-APC-betaCatenin-GSK3B complex
|
A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
|
|
Gata1-Snf2h complex
|
|
|
nNos-Capon-Dexras1 complex
|
|
|
Slam-SAP-SHIP complex
|
|
|
p19-Cdk4-cyclinD2 complex
|
|
|
Nucleolar remodeling complex (NoRC complex)
|
|
|
MBD1-MCAF1-SETDB1 complex
|
|
|
Ubiquitin E3 ligase (NFKBIA, FBXW11, CUL1, SKP1A)
|
|
|
C-CFTR-NHERF(PDZ2 domain)-ezrin complex
|
|
|
SAP complex (Sin3-associated protein complex)
|
|
|
MSH4-MSH5-GPS2 complex
|
|
|
Keap1-Nrf2-Cul3 complex
|
|
|
Epo-R-IP(3)R type II-TRPC2 complex
|
|
|
Abcg8-Abcg4 complex
|
|
|
HTR1D-HTR1B complex
|
|
|
Affixin-actinin(alpha) complex
|
|
|
STAT6-p100-RHA complex
|
|
|
mTOR-signaling complex (mTOR/FRAP1, RAPTOR)
|
|
|
Foxh1-Nkx2-5 complex
|
|
|
FA core complex 1 (Fanconi anemia core complex 1)
|
|
|
MET-CIN85-SH3GL3-CBL complex, HGF stimulated
|
|
|
Ubiquitin E3 ligase (ASB12, TCEB1, TCEB2, CUL5, RNF7)
|
|
|
MTNR1B homodimer complex
|
|
|
PS1-E-cadherin-catenin complex, brain
|
|
|
SNARE complex (VAMP2, SNAP25, STX1a, STX3, CPLX1, CPLX3, CPLX4)
|
|
|
Homotetrameric complex NIAP
|
|
|
RHOA-IP3R-TRPC1 complex
|
|
|
EBAFb complex
|
|
|
Tp53-BAK1 complex
|
|
|
Cohesin complex, incomplete (Smc3, Sycp1, Crest/Ss18I1)
|
|
|
Polycystin-1-E-cadherin-beta-catenin complex
|
|
|
PCAF complex
|
A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs.
|
|
FARP2-NRP1-PlexinA1 complex
|
|
|
Molybdopterin synthase
|
|
|
KCNQ1 macromolecular complex
|
|
|
ITGA2b-ITGB3-TLN1 complex
|
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to talin.
|
|
Brain-derived dystrobrevin-syntrophin complex
|
|
|
SNX complex (SNX1,1a,2,4, PDGF receptor)
|
|
|
Smurf1-Par6 complex
|
|
|
ITGA10-ITGB1 complex
|
|
|
SRC-3 complex
|
|
|
SMAD3-SMAD4-CTCF protein-DNA complex
|
|
|
JAK2-IL12RB2 complex
|
|
|
STAGA complex (SPT3-TAF9-GCN5 acetyltransferase complex)
|
|
|
CTGF/Hcs24-actin complex
|
|
|
BRAFT complex
|
|
|
ASF1-interacting protein complex
|
|
|
AP4 adaptor complex
|
An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo.
|
|
NCOR2 complex
|
|
|
SHARP-CtIP-RBP-Jkappa complex
|
|
|
FOXO3-SIRT1 complex, oxidative stress stimulated
|
|
|
ETS2-SMARCA4-INI1 complex
|
|
|
YBX1-AKT1 complex
|
|
|
DDB2 complex
|
|
|
ARC complex
|
A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA.
|
|
Respiratory chain complex I (incomplete intermediate ND1, ND2, ND3, CIA30 assembly), mitochondrial
|
|
|
DHX9-ADAR-vigilin-DNA-PK-Ku antigen complex
|
|
|
MCM2-MCM6-MCM7 complex
|
|
|
PRMT2 homo-oligomer complex
|
|
|
p97-Ufd1-Npl4-IP3 receptor complex
|
|
|
PKD2-FPC complex
|
|
|
BMP4-TWSG1 complex
|
|
|
PA700 complex
|
|
|
Ryk-Wny1 complex
|
|
|
eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1)
|
|
|
ING2 complex
|
|
|
SMG-1-Upf1-eRF1-eRF3 complex (SURF)
|
|
|
Ubiquitin E3 ligase (SKP1A, BTRC, CUL1)
|
|
|
PLCB1-PARD3-PARD6A complex
|
|
|
Ku antigen-YY1-alphaMyHC promoter complex
|
|
|
APP-FE65-LRP complex
|
|
|
TICAM1-TICAM2-TLR4 complex
|
|
|
p300-CBP-p270 complex
|
|
|
Elongator holo complex
|
|
|
Wave1-Bcl-xl-Pancortin-2 complex, focal ischemic stroke induced
|
|
|
PPP2R1A-PPP2R1B-PPP2CA-PPME1-EIF4A1 complex
|
|
|
IKB(beta)-RELA-cREL complex
|
|
|
Calreticulin oligomer complex
|
|
|
Lab-Grb2 complex, BCR stimulated
|
|
|
PDZK1-NaPiIIa-MAP17 complex
|
|
|
BRMS1-RBP1 complex
|
|
|
Apoptosis- and splicing-associated protein complex (ASAP-L), SAP18-RNPS1-Acinus-L
|
|
|
BRCA1-LMO4-CTIP complex
|
|
|
BCL6-HDAC5 complex
|
|
|
IKK-alpha--ER-alpha-AIB1 complex
|
|
|
POSH-MLK3 complex
|
|
|
GLE1-NUPL2-NUP155 complex
|
|
|
LSm2-8 complex
|
|
|
ABIN2-NFKB1-MAP3K8 complex
|
A protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages.
|
|
NFKB1-NFKB2-REL-RELA-RELB complex
|
|
|
BCDX2 complex
|
A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof.
|
|
BRCA1-HDAC1-HDAC2 complex
|
|
|
ITGAV-ITGB1-SPP1 complex
|
A protein complex that consists of an alphav-beta1 integrin complex bound to osteopontin.
|
|
STAT3-NLK-MAP3K7 complex
|
|
|
BCOR complex
|
|
|
ITGA4-ITGB1-EMILIN1 complex
|
|
|
ITGAV-ITGB6-SPP1 complex
|
A protein complex that consists of an alphaV-beta6 integrin complex bound to osteopontin.
|
|
TFIIE complex
|
|
|
DSIF complex (DRB sensitivity-inducing factor complex)
|
|
|
ActRIIA-ActRIB-Smad3-Arip1 complex
|
|
|
mTORC2 complex (mTOR/FRAP1, LST8, mAVO3/RICTOR)
|
|
|
KSR1-BRAF-MEK complex
|
|
|
TFIIA-TRF2 complex
|
|
|
LSD1-CoREST complex
|
|
|
Sam68-p85 P13K-IRS-1-IR signaling complex
|
|
|
OCT1-OBF1-DNA complex
|
|
|
ITGA8-ITGB1 complex
|
|
|
Cdk5-Cdk5r1-Pctk1 complex
|
|
|
RNA polymerase II core complex
|
|
|
p34(SEI-1)-CDK4-CyclinD2 complex
|
|
|
Ku antigen-NARG1 complex
|
|
|
Slp5-Rab27A complex
|
|
|
Emerin regulatory complex
|
|
|
Cell cycle kinase complex CDK2
|
|
|
Cell cycle kinase complex CDK5
|
|
|
Cell cycle kinase complex CDK4
|
|
|
SNARE complex (STX4, VAMP8, VAMP3, SNAP23)
|
|
|
ITGA4-ITGB1-CD81 complex
|
A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD81, a member of the tetraspan family.
|
|
Mdm2-P53 complex
|
|
|
mSin3A complex
|
|
|
TLE1 corepressor complex (MASH1 promoter-corepressor complex)
|
|
|
Rap1 complex
|
|
|
c-Myc-Max-Arf complex
|
|
|
CAMK2-delta-MASH1 promoter-coactivator complex
|
|
|
PIAS3-SMAD3-P300 complex
|
|
|
SERPINA1-CTSG complex
|
|
|
CTF18-CTF8-DCC1-RFC3 complex
|
|
|
GABAA receptor
|
|
|
Ask1-Traf6 complex, LPS induced
|
|
|
Dystrophin-sarcoglycan-syntrophin complex, skeletal muscle
|
|
|
EGFR-CBL-GRB2 complex
|
|
|
Kir4.1-beta-dystroglycan complex, whole brain lysate
|
|
|
ILK-PARVB-ARHGEF6 complex
|
|
|
XFIM complex
|
|
|
MRE11A-RAD50-NBN-TRF2 complex
|
|
|
EIF3 complex (EIF3B, EIF3G, EIF3I)
|
|
|
CBF1-HDAC1-SMRT complex
|
|
|
CTLH complex
|
|
|
Ubiquitin E3 ligase (CHEK1, CUL4A)
|
|
|
CDC2-PCNA-CCNB1-GADD45G complex
|
|
|
BMP2-BRIA complex
|
|
|
Heterotrimeric G protein complex (GNG2, GNB1, GNAS)
|
|
|
BCL10-MALT1 complex
|
|
|
p97/VCP-VIMP-DERL1 complex
|
|
|
Hdac1-Mecp2-Rcor1-Sin3a complex
|
|
|
Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB)
|
|
|
Kir6.2-Sur1 complex
|
|
|
Respiratory chain complex I (holoenzyme), mitochondrial
|
|
|
MYC-MAX-BLOC1S1 complex
|
|
|
CCND2-CDK4 complex
|
|
|
39S ribosomal subunit, mitochondrial
|
The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
|
|
Sarcoglycan-sarcospan-syntrophin-dystrobrevin complex
|
|
|
PPP3CA-PPP3CA-RCAN1 complex
|
|
|
MutS-beta complex
|
A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3.
|
|
PCNA-CHL12-RFC2-5 complex
|
|
|
PAR-3-VE-cadherin complex, endothelial
|
|
|
ANCO1-HDAC3 complex
|
|
|
ITGB3-ITGAV-VTN complex
|
|
|
IMP3-IMP4-MPP10 complex
|
|
|
BRAF-CNK1 complex, not RAS stimulated
|
|
|
PSD95-FYN-NR2A complex
|
|
|
BRCA1-RNA polymerase II complex
|
|
|
VHL-TBP1-HIF1A complex
|
|
|
TSG101-VPS37B-VPS28 complex
|
|
|
CIN85-SH3GL3 complex
|
|
|
Arp2/3 protein complex
|
A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.
|
|
RANBPM-SMP1 complex
|
|
|
MAML3-RBP-Jkappa-Notch3 complex
|
A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
|
|
SNX complex (SNX1a, SNX2, SNX4)
|
|
|
Olfr992-Rtp1 complex
|
|
|
Upf complex (UPF1, UPF2, UPF3b)
|
|
|
TLE-Histone H3 complex
|
|
|
CRSP-Mediator 2 complex
|
|
|
LATS1-HTRA2-BIRC4 complex
|
|
|
Emerin complex 1
|
|
|
mTOR-signaling complex
|
|
|
HNF4A-SUB1 complex
|
|
|
Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN)
|
|
|
Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1)
|
|
|
Ksr1-Mek-Braf complex, EGF induced
|
|
|
CAND1-CUL1-RBX1 complex
|
|
|
Exosome
|
|
|
SKI-SMAD3-SMAD4 pentameric complex
|
|
|
Actin-ribonucleoprotein complex (POLR2A, GTF2F1, HNRNPU)
|
|
|
Src-dynamin-synapsin complex
|
|
|
NDPKA-AMPKalpha1 complex
|
|
|
PKD2-PACS1 complex
|
|
|
Ubiquitin E3 ligase (CUL1, RBX1, SKP1A)
|
|
|
ATR-HDAC2-CHD4 complex
|
|
|
Smooth muscle sarcoglycan complex SGC, beta-delta-zeta
|
|
|
Grb2-Lab-Blnk complex, BCR stimulated
|
|
|
TTP-AGO2 complex
|
|
|
DNMT3L-DNMT3A complex
|
|
|
P-TEFb-SKP2 complex
|
|
|
Mt3-Hsp84-Ck complex
|
|
|
SMAD2-SKI complex
|
|
|
Drosha complex
|
|
|
CCT complex (chaperonin containing TCP1 complex)
|
|
|
NCOA6-DNA-PK-Ku-PARP1 complex
|
|
|
SMN complex (GEMIN5,4,3), SMN-independent intermediate
|
|
|
SORT1-NGFR complex
|
|
|
53BP1-containing complex
|
|
|
BRCA1-BARD1-POLR2A complex
|
|
|
Ku70/Ku86/Werner complex
|
|
|
HES1 promoter corepressor complex
|
|
|
Mediator complex 1
|
|
|
GCN5-TRRAP histone acetyltransferase complex
|
|
|
NR3C2-UBC9-SRC-1 complex
|
|
|
MNK1-eIF4F complex
|
|
|
beta(1)-AR receptosome (ADRB1-SAP97-AKAP79-PRKAR2A)
|
|
|
ITGAV-ITGB3-SPP1 complex
|
A protein complex that consists of an alphav-beta3 integrin complex bound to osteopontin.
|
|
ITGA3-ITGB1-BSG complex
|
A protein complex that consists of an alpha3-beta1 integrin complex bound to the cell surface protein basigin.
|
|
DNA synthesome complex (17 subunits)
|
|
|
UTM-SGCE-DAG1-CAV1-NOS3 complex
|
|
|
Elongator core complex
|
A heterohexameric protein complex that is involved in modification of wobble nucleosides in tRNA, and exerts direct effects on transcriptional elongation and exocytosis. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes.
|
|
18S U11/U12 snRNP
|
|
|
Itgax-Itgb2-Icam4 complex
|
A protein complex that consists of an alphaX-beta2 integrin complex bound to intercellular adhesion molecule 4.
|
|
RAD51-DMC1 complex
|
|
|
CDC7-DBF7 complex
|
|
|
Prnp homodimer complex
|
|
|
EED-EZH polycomb complex
|
|
|
ER-alpha-GRIP1-c-Jun complex
|
|
|
Ubiquitin E3 ligase (UBADC1, RNF123)
|
|
|
ITGA9-ITGB1-VEGFA complex
|
A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor A.
|
|
APLG1-Rababtin5 complex
|
|
|
Polycomb repressive complex
|
|
|
HTR1A-GPR26 complex
|
|
|
Phosphatidylinositol 3-kinase complex (PIK3C3, PIK3R4)
|
|
|
SP1-MCAF2 complex
|
|
|
HIF1A-OS9-EGLN1 complex
|
|
|
MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex)
|
|
|
Ubiquitin E3 ligase (GLMN, FBXW8, SKP1A, RBX1)
|
|
|
N-WASp homomer
|
|
|
Respiratory chain complex I (intermediate II/230kD), mitochondrial
|
|
|
mTORC1 complex (mTOR/FRAP1, LST8, RAPTOR)
|
|
|
VEGFA(165)-VEGFR2-NRP1 complex
|
|
|
Cohesin complex, incomplete (Sycp1, Crest/Ss18I1, Rec8)
|
|
|
TFIIH transcription factor complex
|
|
|
CDK2-CCNA2 complex
|
|
|
Anaphase-promoting complex
|
A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
|
|
BRCA1-SMAD3 complex
|
|
|
PAX9-MSX1 complex
|
|
|
ITGAV-ITGB5-ADAM9 complex
|
|
|
12S U11 snRNP
|
|
|
PRNP homo-oligomer complex
|
|
|
Nrp1-PlexinD1 complex
|
|
|
PNUTS-PP1 complex
|
|
|
RAB5-EEA1 complex
|
|
|
Checkpoint Rad complex
|
|
|
ESPL1-CDC2 complex
|
|
|
Prolyl 4-hydroxylase (alpha(III)-type)
|
|
|
RC complex during G2/M-phase of cell cycle
|
|
|
TFIID subcomplex, testis-specific
|
|
|
CFTR-NHERF-beta(2)AR signaling complex
|
|
|
p33ING1b-p300 complex
|
|
|
P-TEFb-7SKRNA-HEXIM1 complex
|
|
|
Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1)
|
|
|
SNARE complex (Vti1b, Stx6, Stx7)
|
|
|
Mad-Max-mSin3B complex
|
A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3B, a homolog of the yeast Sin3p.
|
|
ITGA4-ITGB1-VCAM1 complex
|
|
|
P2X7 receptor signalling complex
|
|
|
PRKAC-AKAP5-ADRB1 complex
|
|
|
GINS complex
|
A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks.
|
|
HSP70-BAG5-PARK2 complex
|
|
|
Axin-Dvl-Gsk-Frat1 complex
|
|
|
LARC complex (LCR-associated remodeling complex)
|
|
|
ITGA2-ITGB1 complex
|
|
|
CREBBP-SMAD2-SMAD4 pentameric complex
|
|
|
p53-Bcl-xL complex, DNA-damage induced
|
|
|
P-TEFb.4 complex
|
|
|
BRM-SIN3A complex
|
|
|
Sec61alpha-CollagenIV-Hsp47 complex
|
|
|
p97/VCP-VIMP-DERL1-DERL2-HRD1-SEL1L complex
|
|
|
SNX complex (SNX2), oligomeric
|
|
|
MALT1 oligomer complex
|
|
|
AP3 adapter complex
|
|
|
MSH2-MLH1-PMS2 DNA-repair initiation complex
|
|
|
TTP-AGO4 complex
|
|
|
CTF8-CTF18-DCC1 subcomplex
|
|
|
CREBBP-SMAD3 hexameric complex
|
|
|
Ryk-Wny1-Fzd8 complex
|
|
|
SLP-76-Cbl-Grb2-Shc complex, Fc receptor gamma-R1 stimulated
|
|
|
PCNA-DNA ligase complex
|
|
|
N-NOS-CHIP-HSP70-1 complex
|
|
|
SMURF2-SMAD3-SnoN complex, TGF(beta)-dependent
|
|
|
STAT5A homodimer complex
|
|
|
CERF complex (CECR2-containing remodeling factor complex)
|
|
|
MTA1 complex
|
|
|
TRF2-Ku complex
|
|
|
MSH2/6-BLM-p53-RAD51 complex
|
|
|
PLXNA3-RANBPM complex
|
|
|
SHC-GRB2 complex
|
|
|
Respiratory chain complex I (intermediate I/200kD and III/250kD), mitochondrial
|
|
|
FA complex (Fanconi anemia complex), cytoplasmic
|
|
|
Conserved oligomeric Golgi (COG) complex
|
|
|
Serine-palmitoyltransferase (SPT) complex
|
|
|
TIM50a-coilin complex
|
|
|
Kir4.1-dystrophin complex, cortical astrocytes
|
|
|
Nitric oxide synthase-dystrophin complex, skeletal muscle
|
A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase.
|
|
Nucleic and chromatin Fanconi complex
|
|
|
SF3b complex
|
|
|
Kv4.2-DPP10 channel complex
|
|
|
MPP4-MPP5-CRB1 complex
|
|
|
Polycomb repressive complex 2 (PRC 2)
|
|
|
Mi2/NuRD-BCL6-MTA3 complex
|
|
|
Shc-Ship-Grb2 complex, IL-3 stimulated
|
|
|
Prefoldin
|
|
|
H2AX complex, isolated from cells without IR exposure
|
|
|
ArgBP2a-CBL-PTK2B complex
|
|
|
ERBB2-MEMO-SHC complex
|
|
|
PDGFRA-SHP-2 complex, PDGF stimulated
|
A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.
|
|
ABL2-HRAS-RIN1 complex
|
|
|
PTIP-HMT complex
|
|
|
Sdc2-Ephb2 complex
|
|
|
DNMT1-RB1-HDAC1-E2F1 complex
|
|
|
PLEKHM2-KIF5B complex
|
|
|
Epo-R-PLC-gamma 1-IP(3)R type II-TRPC2 signaling complex
|
|
|
Apaf1 homo-oligomer complex
|
|
|
MAD1L1-MAD2L1 complex
|
|
|
MICA-KLRK1-HCST complex
|
|
|
Respiratory chain complex I (intermediate V/380kD and VI/480kD), mitochondrial
|
|
|
GIPC1-LHCGR complex
|
|
|
CDH23-harmonin transmembrane complex
|
|
|
RFC2-RIalpha complex
|
|
|
13S condensin complex
|
A multisubunit protein complex that plays a central role in chromosome condensation.
|
|
MRIP-RHOA complex
|
|
|
CCT complex (chaperonin containing TCP1 complex), testis specific
|
|
|
NCOR-HDAC3 complex
|
|
|
CS-MAP3K7IP1-MAP3K7IP2 complex
|
|
|
Cohesin-SA2 complex
|
|
|
FA complex (Fanconi anemia complex)
|
|
|
DAXX-Axin-p53-HIPK2 complex
|
|
|
DNA synthesome complex
|
A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.
|
|
Pcdha7-Pcdhga3 complex
|
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane.
|
|
XRCC1-LIG3-PNK-TDP1 complex
|
|
|
PIN1-AUF1 complex
|
|
|
Kif3-cadherin-catenin complex
|
|
|
anti-BHC110 complex
|
|
|
LINC complex, quiescent cells
|
|
|
LMO4-CREB complex
|
|
|
SIN3-ING1b complex II
|
|
|
Membrane protein complex (VCP, UFD1L, SEC61B)
|
|
|
FIB-associated protein complex
|
|
|
hNURF complex
|
|
|
NK-3-Groucho-HIPK2-SIN3A-RbpA48-HDAC1 complex
|
|
|
CtBP complex
|
|
|
Emerin architectural complex
|
|
|
SMAD3/4-E2F4/5-p107-DP1 complex
|
|
|
DNA ligase III-XRCC1 complex
|
A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair.
|
|
p53 homotetramer complex
|
|
|
CDK4-CCND1 complex
|
|
|
FGFR2-c-Cbl-Lyn-Fyn complex
|
|
|
NMI homodimer complex
|
|
|
LIFR-LIF-gp130 complex
|
|
|
CCND1-CDK6 complex
|
|
|
TFIIIC containing complex TFIIIC2
|
|
|
p27-cyclinE-CDK2 complex
|
|
|
Il3rb1-Shc complex, IL-3 stimulated
|
|
|
ITGA3-ITGB1-CD151 complex
|
A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD151.
|
|
Kaiso-NCOR complex
|
|
|
IL12B-IL12RB1-IL12RB2 complex
|
|
|
Itga-Itgb1-Ppap2b complex
|
|
|
Sur2 subcomplex of mediator
|
|
|
SWI/SNF chromatin-remodeling complex (Mecp2, Smarc)
|
|
|
Birc6 homodimer complex
|
|
|
PUMA-Bcl-xL complex, DNA-damage induced
|
|
|
Pallidin-Mu complex
|
|
|
Stat1-alpha-dimer-CBP DNA-protein complex
|
|
|
RIN1-STAM2-EGFR complex, EGF stimulated
|
|
|
PEX14 homodimer complex
|
|
|
CASP8-FADD-MALT1-BCL10 complex
|
|
|
Arnt-Sim1 complex
|
|
|
Grb2-mSos1 complex
|
A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
|
|
ITGAV-P2RY2-GNA12 complex
|
|
|
TCF4-CTNNB1 complex
|
|
|
Ubiquitin E3 ligase (BMI1, SPOP, CUL3)
|
|
|
Tubulin polyglutamylase complex
|
|
|
Anti-SMN protein complex
|
|
|
MMP-9-TIMP-1-LRP complex
|
|
|
Ldb1-Lmo2-Gata-1-Tal1-E47 complex
|
|
|
SNX complex (SNX1a, SNX2, SNX4, INSR)
|
|
|
MTA2 complex
|
|
|
AP1G1-PACS1-FURIN complex
|
|
|
RAD51B-RAD51C-RAD51D-XRCC2-XRCC3 complex
|
|
|
VEGFA(165)-KDR-NRP1 complex
|
|
|
MGC1-DNA-PKcs-Ku complex
|
|
|
Pcdhga1-Pcdhga3 complex
|
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane.
|
|
PCI-PSA-SCG2 complex
|
|
|
IFP35-NMI complex
|
|
|
IGF1-IGFBP3-ALS complex
|
|
|
DAP12 signaling homodimer complex
|
|
|
IRF3-CBP complex
|
|
|
E2F1-Rb complex
|
|
|
Cohesin complex, incomplete (Smc1b, Crest/Ss18I1)
|
|
|
p54(nrb)-PSF-matrin3 complex
|
|
|
ATM-NBS1 complex
|
|
|
CDC5L core complex
|
|
|
Ubiquitin E3 ligase (Skp1A, Skp2, Cul1, Rbx1)
|
|
|
6S-nuclear aryl hydrocarbon (Ah) receptor ligand-activated complex
|
|
|
BKCA-beta2AR complex
|
|
|
TIMM17-TIMM23 complex
|
|
|
Sororin-cohesin complex
|
|
|
MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex
|
|
|
ITGAV-ITGB6 complex
|
|
|
IL12RB1-IL12RB2 complex
|
|
|
HIF1A-OS9-EGLN3 complex
|
|
|
Ubiquitin ligase complex (TRAF6, TAB2, MALT1, UEV1A, BCL10)
|
|
|
BCR-ABL (p210 fusion protein)-GRB2-SOS1 complex
|
|
|
ITGAV-ITGB3-ADAM15 complex
|
A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM15.
|
|
CDC5L complex
|
|
|
TFIID complex, B-cell specific
|
A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4.
|
|
BASC (Ab C-20) complex (BRCA1-associated genome surveillance complex)
|
|
|
Apoptosis- and splicing-associated protein complex (ASAP-S), SAP18-RNPS1-Acinus-S
|
|
|
SCRIB-APC complex
|
A protein complex that contains the Scribble protein (a cell polarity determinant) and the tumor suppressor protein adenomatous polyposis coli (APC); may be involved in the control of cell proliferation.
|
|
CDC2-CCNA2 complex
|
|
|
Yy1-Ppargc1a complex
|
|
|
Ubiquitin E3 ligase (ASB2, TCEB1, TCEB2, CUL5, RNF7)
|
|
|
SMARCA2/BRM-BAF57-MECP2 complex
|
|
|
Casein kinase II (beta-dimer, alpha'-dimer)
|
|
|
FE65-TSHZ3-HDAC1 complex
|
|
|
PTPRA homodimer complex
|
|
|
MKK4-ARRB2-JNK3 complex
|
|
|
HBO1 complex
|
|
|
SMAD3-SMAD4-SP1 complex
|
|
|
Grin2a-Lrp8 complex
|
|
|
BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I
|
|
|
HDAC4-ERK1 complex
|
|
|
CRLR-RAMP2 complex
|
|
|
IPO13-RBM8A-MAGOH complex
|
|
|
CIN85-CBL complex
|
|
|
LSD1 complex
|
|
|
PID complex
|
|
|
Profilin 2 complex
|
|
|
ITGA1-ITGB1-PTPN2 complex
|
A protein complex that consists of an alpha1-beta1 integrin complex bound to tyrosine-protein phosphatase non-receptor type 2.
|
|
CCND1-CDK4 complex
|
|
|
Emerin complex 52
|
|
|
BAX-BAK-IRE1alpha complex
|
|
|
ATP-utilizing chromatin assembly and remodeling factor (hACF) complex
|
|
|
E2F4-p107-cyclinA complex
|
|
|
IRAK1-IRAK3 complex
|
|
|
pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300)
|
|
|
ITGA6-ITGB4-LAMA5 complex
|
A protein complex that consists of an alpha6-beta4 integrin complex bound to laminin 5.
|
|
Ubiquitin E3 ligase (FBXW11, SKP1A, CUL1, RBX1)
|
|
|
CCND3-CDK4 complex
|
|
|
CD98-LAT2-ITGB1 complex
|
|
|
Skeletal muscle sarcoglycan complex SGC, alpha-beta-gamma-delta
|
|
|
Cebpa-Smarca2 complex
|
|
|
20S methylosome and RG-containing Sm protein complex
|
|
|
PRMT1 complex
|
|
|
DGCR8 multiprotein complex
|
|
|
SNW1 complex
|
|
|
ITGAM-ITGB2-CD11 complex
|
|
|
SMAD2-SKI-NCOR complex
|
|
|
Cohesin complex, incomplete (Sycp2, Crest/Ss18I1)
|
|
|
TRPC1-TRPC3-TRPC7 complex
|
|
|
BRD4 complex
|
|
|
Mss4-Itga7 complex
|
|
|
DA complex
|
|
|
AP3D1-AP3S1 complex
|
|
|
JUN-TCF4-CTNNB1 complex
|
|
|
Securin-separase complex
|
|
|
PSF-p54(nrb) complex
|
|
|
DSS1 complex
|
|
|
RAD50-MRE11-NBN-p200-p350 complex
|
|
|
CAK complex (Cdk-activating kinase complex)
|
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|
SWI/SNF-related complex
|
|
|
TGF-beta receptor-SMAD3 complex
|
|
|
LLGL1-PAR-6B-PRKCI complex
|
|
|
Grb2-Shp2 complex, FGF stimulated
|
|
|
mPar6c-Mlgl-aPKC complex
|
|
|
ARNT-HIF1A complex
|
|
|
AXL homodimer complex
|
|
|
BLM complex II
|
|
|
EXO1-MLH1-PCNA complex
|
|
|
Chromatin assembly complex (CAF-1 complex)
|
|
|
Grb2-Sos complex, Fc receptor gamma-R1 stimulated
|
|
|
ITGA4-ITGB1-CD53 complex
|
A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family.
|
|
TFIIF complex (transcription factor IIF)
|
|
|
CAK core complex (Cdk-activating kinase core complex)
|
|
|
LMO4-gp130 complex
|
|
|
PAC3-PAC4 complex
|
|
|
MRIP-MBS complex
|
|
|
APC-Axin-1-beta-catenin complex
|
A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
|
|
LAT2-ITGB1 complex
|
|
|
ITGA5-ITGB1-FN1-TGM2 complex
|
A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and tissue transglutaminase.
|
|
PCNA-RFC2-5 complex
|
|
|
Gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)
|
|
|
Skeletal muscle sarcoglycan complex SGC, alpha-beta-epsilon-gamma
|
|
|
FKBP12-FK506 complex
|
|
|
SNARE complex (STX2, SNAP23)
|
|
|
Slam-SAP complex
|
|
|
POLR1B-RRN3 complex
|
|
|
DCS complex (PTBP1, PTBP2, HNRPH1, HNRPF)
|
|
|
ITGA9-ITGB1-ADAM12 complex
|
A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM12.
|
|
HPFH(-198) complex
|
|
|
Rag1-Rag2-Ku70-Ku80 protein-DNA complex
|
|
|
SP1-E2F1 complex
|
|
|
CHUK-IQGAP2-AKAP8L-RELA-TNIP2 complex
|
|
|
Cbl-Cd2ap complex
|
|
|
p300-CBP-p270-SWI/SNF complex
|
|
|
Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1)
|
|
|
RICH1/AMOT polarity complex, Flag-Rich1 precipitated
|
|
|
TRAF6 oligomer complex
|
|
|
ITGA5-ITGB1-ADAM15 complex
|
|
|
hMediator complex (MED23, CDK8, CCNC)
|
|
|
CASK-LIN7C-APBA1 complex
|
|
|
Neurotrophin-3-p75 complex
|
|
|
SNARE complex (VAMP2, SNAP25, STX13)
|
|
|
Tiam1-Par-3-aPKC-zeta complex
|
|
|
Ubiquitin E3 ligase (CHEK1, CUL1)
|
|
|
OCT2-TLE4 complex
|
|
|
TNPO2-RAN-NXF1 complex
|
|
|
MYOM1 homodimer complex
|
|
|
p97/VCP-VIMP-DERL2 complex
|
|
|
IL4-IL4R-IL2RG complex
|
|
|
Src1-Ep300-Crebbp complex
|
|
|
CHL2-BMP2-TSG complex
|
|
|
BHC110 complex
|
|
|
RNA polymerase II holoenzyme complex
|
|
|
ITGAV-ITGB3 complex
|
|
|
Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3)
|
|
|
Class C VPS/HOPS complex
|
|
|
CBC complex (cap binding complex)
|
|
|
Er-alpha-p53-hdm2 complex
|
|
|
BRM-SIN3A-HDAC complex
|
|
|
RIAM-VASP complex
|
|
|
PGC-1-SRp40-SRp55-SRp75 complex
|
|
|
FEN1-9-1-1 complex
|
|
|
Hop2-Mnd1 complex
|
|
|
ITGA9-ITGB1-ADAM9 complex
|
A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM9.
|
|
RFC complex
|
A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase.
|
|
I(kappa)B(alpha)-NF(kappa)Bp50-NF(kappa)Bp65 complex
|
|
|
Rab3a-Rims2-Rapgef4 complex
|
|
|
FYB-CARMA1-BCL-10-MALT1 complex
|
|
|
PLC-gamma-2-SLP-76-Lyn-Grb2 complex
|
|
|
DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1
|
|
|
NCOR-SIN3-RPD3 complex
|
|
|
CtBP core complex
|
|
|
RPAP1-RPB2-RPB3 complex
|
|
|
PPP4C-PPP4R2-Gemin3-Gemin4 complex
|
|
|
LLGL2-PAR-6B-PRKCI complex
|
|
|
ETS2-ERG complex
|
|
|
Yy1-Ppargc1a-Frap1 complex
|
|
|
cRET-Shc-Grb2-Gab2-P85PI3K-Shp2 complex
|
|
|
TREX complex
|
The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans.
|
|
Prune/Nm23-H1 complex
|
|
|
CRK-BCAR1-DOCK1 complex
|
|
|
ITGA3-ITGB1-CD63 complex
|
A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD63.
|
|
Ecsit complex (Smad1-Smad4-Ecsit2)
|
|
|
PCNA homotrimer complex
|
|
|
gp78-p97/VCP-DERL1 complex
|
|
|
SNARE complex (VAMP2, SNAP25, STX1a, CPLX2)
|
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof).
|
|
PRMT2 homodimer complex
|
|
|
BASC (Ab 81) complex (BRCA1-associated genome surveillance complex)
|
|
|
GTP-Rho-Rhpn1-Ropn1 complex
|
|
|
ORC 2-4 complex (origin recognition 2-4 complex)
|
|
|
PU.1-SIN3A-HDAC complex
|
|
|
PXN-ITGB5-PTK2 complex
|
|
|
Adiponectin homohexamer complex
|
|
|
IGHM-VPREB1-IGLL1 complex
|
|
|
Axin-p53-HIPK2 complex
|
|
|
Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1)
|
|
|
Ccd1-Dvl2 complex
|
|
|
IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex
|
|
|
Cbl-Cd2ap-Flt1 complex
|
|
|
IL12A-IL12B-IL12RB1 complex
|
|
|
Y14-Magoh complex
|
|
|
PlexinA1-PlexinB1 complex
|
|
|
60S ribosomal subunit, cytoplasmic
|
|
|
CPSF6-ITCH-NUDT21-POLR2A complex
|
|
|
IKBKG homodimer complex
|
|
|
BLOC1-BLOC2 complex
|
|
|
ITGA5-ITGB1-CAL4A3 complex
|
A protein complex that consists of an alpha5-beta1 integrin complex bound to endostatin, the NC1 domain of the alpha1 chain of type XVIII collagen.
|
|
Gata2-Tal1-Tcf3-Lmo2 complex
|
A protein complex that contains the zinc finger transcription factor GATA2, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis.
|
|
Pcdha7-Pcdhgb2 complex
|
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane.
|
|
Membrane-associated multicomponent signaling complex, anti-CD40 stimulated (Cd40, Ikbkg, Map3k1, Traf2, Ube2n)
|
|
|
tBID-BAK1 complex
|
|
|
NRP1-VEGF(165/121) complex
|
|
|
Kif17-Lin10-Lin2-Lin7-NR2B complex
|
|
|
RAF1-BRAF complex, RAS stimulated
|
|
|
Multiprotein complex (monoubiquitination)
|
|
|
Map2k5-Map3k3 complex
|
|
|
EDG1-HTR1D complex
|
|
|
RAD52-ERCC4-ERCC1 complex
|
A nucleotide-excision repair complex formed by the association of the heterodimeric endonuclease XPF/ERCC4-ERCC1 (Rad1p and Rad10p in S. cerevisiae) with the RAD52 protein.
|
|
MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex
|
|
|
Succinyl-CoA synthetase, ADP-forming
|
A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP.
|
|
Itga4-Itgb1-Adam2 complex
|
|
|
SMAD4-SMAD2-SMAD3 complex
|
|
|
ITGA6-ITGB4-CD9 complex
|
A protein complex that consists of an alpha6-beta4 integrin complex bound to the cell surface protein CD9.
|
|
p32-CBF-DNA complex
|
|
|
ARNT-HLF complex
|
|
|
Exon junction complex (F4A3-MLN51-UPF3B-MAGOH-Y14-PYM)
|
|
|
Protein kinase A II alpha homodimer complex
|
|
|
Upf complex (UPF1, UPF2, UPF3a)
|
|
|
Respiratory chain complex I (early intermediate NDUFAF1 assembly), mitochondrial
|
|
|
CBP-RARA-RXRA-DNA complex, ligand stimulated
|
|
|
MDC1-MRN-ATM-FANCD2 complex
|
|
|
Metallothionein-3 complex
|
|
|
Polycomb repressive complex 2 (PRC2)
|
|
|
20S methyltransferase complex
|
A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.
|
|
MYC-MAX complex
|
A transcription factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max.
|
|
ITGA5-ITGB3-COL6A3 complex
|
|
|
NTF4 homodimer complex
|
|
|
TRF2-Rap1 complex II
|
|
|
BRCA1-cABL complex
|
|
|
ATR-HDAC2 complex
|
|
|
AMY-1-S-AKAP84-RII-beta complex
|
|
|
KIN17-PCNA-RPA70 complex
|
|
|
ING4 complex (ING4, MYST2, C1orf149, PHF17)
|
|
|
BRCA1-RAD51 complex
|
A protein complex that contains BRCA1 and Rad 51, and is involved in the control of recombination and of genome integrity.
|
|
Rab5 GDP/GTP exchange factor complex
|
|
|
BLM-TRF2 complex
|
|
|
Apoptosome-procaspase 9 complex
|
|
|
AR coactivator complex
|
|
|
TIM (TIMM9, TIMM10) complex, mitochondrial
|
|
|
Limd1-p62-Traf6-Prkcz complex
|
|
|
TRIM27-RB1 complex
|
|
|
NFKB1-NFKB2-RELA-RELB complex
|
|
|
Gamma-BAR-AP1 complex
|
|
|
PA700-20S-PA28 complex
|
|
|
Foxo4-Srf-Myocd complex
|
|
|
ERdj3-BiP complex
|
|
|
Myod1 homodimer complex
|
|
|
BETA2-Cyclin D1 complex
|
|
|
ITGA6-ITGB1 complex
|
|
|
SRA-SRC-1 ribonucleoprotein complex
|
|
|
FOXO3-TP53 complex, oxidative stress stimulated
|
|
|
BRG1-SIN3A complex
|
|
|
Pcdha7-Pcdhgb4 complex
|
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane.
|
|
mTORC2 complex (mTOR/FRAP1, LST8, mAVO3/RICTOR, SIN1)
|
|
|
E2F1-p107-cyclinA complex
|
|
|
ZAP70-CRKL-WIPF1-WAS complex
|
|
|
SKI complex
|
A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p.
|
|
Telosome complex
|
|
|
MAP2K5-PRKCI-SQSTM1 complex
|
|
|
THO complex
|
The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.
|
|
ORC5-ORC1 complex
|
|
|
TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2)
|
|
|
SNARE complex (STX1A, SNAP29)
|
|
|
Multisynthetase complex
|
A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates.
|
|
HSP90-CIP1-FKBPL complex
|
|
|
KLC1-nKHC-uKHC kinesin complex
|
|
|
SHC3-GAB1 complex
|
|
|
CHUK-ERC1-IKBKB-IKBKG
|
|
|
RIAM-profilin complex
|
|
|
Amyloid beta protein oligomer
|
|
|
Ikaros complex
|
|
|
Catulin (alpha) - catenin (beta) complex
|
|
|
20S proteasome
|
|
|
TFIIIC containing complex
|
|
|
CyclinB1-Cdc2 complex
|
|
|
SMAD3-E2F4/5-p107-DP1 complex
|
|
|
HERP1/HEY2-NCOR-SIN3A complex
|
|
|
GABP(gamma)1-E2F1-DP1 complex
|
|
|
BARD1-BRCA1-CSTF64 complex
|
|
|
PLC-gamma-2-Lyn-FcR-gamma complex
|
|
|
ITGA9-ITGB1-VEGFC complex
|
A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor C.
|
|
Paf complex
|
|
|
Nfatc2ip-Prmt1
|
|
|
BRCA1-BARD1-UbcH5c complex
|
|
|
Beta-dystroglycan-caveolin-3 complex
|
|
|
Grin2b-Lrp8 complex
|
|
|
Ecsit complex (ECSIT, MT-CO2, GAPDH, TRAF6, NDUFAF1)
|
|
|
SMC1-SMC3 complex
|
The core heterodimer of a cohesin complex; a structure required for sister chromatid cohesion in eukaryotes.
|
|
TNF-alpha/NF-kappa B signaling complex 6
|
|
|
TERF2-RAP1 complex
|
|
|
Xin-Cdh2-Ctnnb1-Ctnnd1 complex
|
|
|
IKB(alpha)-RELA-cREL complex
|
|
|
RIN1-STAM2-HRS complex
|
|
|
SCRIB-VANGL2 complex
|
|
|
E2F4-p107-cyclinE complex
|
|
|
ELK1-SRF-ELK4 complex
|
|
|
Brg1-based SWI/SNF chromatin remodeling complex
|
|
|
SERPINA1-ELA2 complex
|
|
|
SMAD3-SMAD4-cJun-cFos complex
|
|
|
SMAD4-SKI-NCOR complex
|
|
|
Itgav-Itgb3-Gsn complex
|
A protein complex that consists of an alphaV-beta3 integrin complex bound to gelsolin.
|
|
AP3-BLOC1 complex
|
|
|
BASC complex (BRCA1-associated genome surveillance complex)
|
|
|
Rpa2-Rrn3 complex
|
|
|
Nmi-Rpa2-Rrn3 complex
|
|
|
Ubiquitin E3 ligase (SPOP, DAXX, CUL3)
|
|
|
SNARE complex (SNAP23, STX1A)
|
|
|
ESR1-RELA-BCL3-NCOA3 complex
|
|
|
AGPS-GNPAT complex
|
|
|
RAD51B-RAD51C complex
|
A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof.
|
|
p18-Cdk6 complex
|
|
|
SNARE complex (STX4, SNAP23)
|
|
|
Cell-cell junction complex (CDH1-CTNNB1)
|
|
|
ITGA2b-ITGB3-CD9-GP1b-CD47 complex
|
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface proteins CD9 and CD47, and the heterodimeric platelet glycoprotein Ib.
|
|
BCL10 oligomer complex
|
|
|
BRCA1-BARD1-UbcH7c complex
|
|
|
Ubiquitin E3 ligase (Neurl2, Tceb1, Tceb2, Cul5, Rbx1)
|
|
|
SNF2h-HDAC12 complex
|
|
|
RAF1-CNK1 complex, RAS stimulated
|
|
|
Transcription elongation factor complex (SUPT5H, CDK9, CCNT1)
|
|
|
ITGA6-ITGB4 complex
|
|
|
RPA complex
|
|
|
DNA ligase IV-XRCC4-PNK complex
|
|
