2075 sets of proteins in protein complexes from the CORUM Protein Complexes dataset.
Gene Set |
Description |
(C-CFTR)2-NHERF-ezrin complex
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(E.F.G) complex
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A protein complex that comprises three core spliceosomal proteins, designated E, F, and G. Formation of the E.F.G complex is essential but not sufficient for the formation of a stable U1 snRNP complex.
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(ER)-localized multiprotein complex, Ig heavy chains associated
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(ER)-localized multiprotein complex, in absence of Ig heavy chains
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12S U11 snRNP
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13S condensin complex
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A multisubunit protein complex that plays a central role in chromosome condensation.
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17S U2 snRNP
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18S U11/U12 snRNP
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20S methylosome and RG-containing Sm protein complex
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20S methylosome-SmD complex
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20S methyltransferase complex
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A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.
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20S methyltransferase core complex
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20S proteasome
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26S proteasome
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28S ribosomal subunit, mitochondrial
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2AR-mGluR2 complex
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39S ribosomal subunit, mitochondrial
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The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
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40S ribosomal subunit, cytoplasmic
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53BP1-containing complex
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55S ribosome, mitochondrial
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A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes.
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5S-DNA-TFIIIA-TFIIIC2 subcomplex
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5S-DNA-TFIIIA-TFIIIC2-TFIIIB subcomplex
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60S APC containing complex
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60S ribosomal subunit, cytoplasmic
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6S methyltransferase and RG-containing Sm proteins complex
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6S methyltransferase complex
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6S-nuclear aryl hydrocarbon (Ah) receptor ligand-activated complex
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9-1-1 complex
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9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex
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Abcg5-Abcg1 complex
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Abcg5-Abcg2 complex
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Abcg5-Abcg4 complex
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Abcg5-Abcg8 complex
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Abcg8-Abcg4 complex
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ABI1-WASF2 complex
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ABI1-WASL complex
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ABIN2-NFKB1-MAP3K8 complex
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A protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages.
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ABL2-HRAS-RIN1 complex
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Acinar cell-specific C complex
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A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes.
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ACT homodimer complex
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ACT-CREB complex
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Actin-ribonucleoprotein complex (POLR2A, GTF2F1, HNRNPU)
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ActRIIA-ActRIB-Smad3-Arip1 complex
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ADAR1-CDK2 complex
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Adiponectin homohexamer complex
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Adiponectin homotrimer complex
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ADRB2 homodimer complex
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AFF1-MLLT1-CBX8 complex
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Affixin-actinin(alpha) complex
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Agap11-AP3 complex
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AGO2-FXR1-TNF(alpha)ARE-RNP complex
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AGPS-GNPAT complex
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Agtr1a-Jak2 complex
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AIF-CYPA-DNA complex
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Aip-Hsp90-Ahr complex
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AIRE homodimer complex
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AK2-FADD-caspase-10 (AFAC10) complex
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AKAP250-PKA-PDE4D complex
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ALL-1 supercomplex
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AMY-1-S-AKAP84-RII-beta complex
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Amyloid beta protein oligomer
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Anaphase-promoting complex
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A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
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ANCO1-HDAC3 complex
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Angiomotin isoform p80-Angiostatin complex
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anti-BHC110 complex
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Anti-HDAC2 complex
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Anti-Sm protein complex
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Anti-SMN protein complex
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AOF2-AR complex
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AP1 adaptor complex
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A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).
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AP1G1-PACS1-FURIN complex
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AP3 adapter complex
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AP3-BLOC1 complex
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AP3D1-AP3S1 complex
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AP3D1-AP3S2 complex
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AP4 adaptor complex
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An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo.
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Apaf1 homo-oligomer complex
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APC-Axin-1-beta-catenin complex
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A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
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APC-DLG4 complex
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Apg16L-Apg12-Apg5 complex
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APH1A-PSEN1-NCSTN complex
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APH1A-PSEN2-NCSTN complex
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APLG1-Rababtin5 complex
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Apoptosis- and splicing-associated protein complex (ASAP-L), SAP18-RNPS1-Acinus-L
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Apoptosis- and splicing-associated protein complex (ASAP-S), SAP18-RNPS1-Acinus-S
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Apoptosome
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A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms.
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Apoptosome-procaspase 9 complex
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APP-FE65-LRP complex
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APP-TIMM23 complex
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APP-TOMM40 complex
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APPBP1-UBA3 complex
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AR coactivator complex
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AR-AKT-APPL complex
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ARC complex
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A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA.
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ARC-L complex
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ARC92-Mediator complex
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ARD1-NATH complex
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ARF-Mule complex
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ArgBP2a-CBL-PTK2B complex
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ARNT-HIF1A complex
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ARNT-HLF complex
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Arnt-Sim1 complex
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Arnt-Sim2 complex
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Arp2/3 protein complex
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A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.
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Artemis-DNA-PK complex
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ASCOM complex
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ASF1-histone containing complex
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ASF1-interacting protein complex
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Ask1-Traf6 complex, LPS induced
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ASPP1-SAM68 complex
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ATM homodimer complex
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ATM-NBS1 complex
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ATP-utilizing chromatin assembly and remodeling factor (hACF) complex
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ATR-ATRIP complex
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A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A.
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ATR-HDAC2 complex
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ATR-HDAC2-CHD4 complex
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ATRX-DAXX complex
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AXIN-APC-betaCatenin-GSK3B complex
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A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
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Axin-Dvl-Gsk complex
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Axin-Dvl-Gsk-Frat1 complex
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Axin-Mekk4 complex
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AXIN-MEKK4-CCD1 complex
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Axin-p53-HIPK2 complex
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Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex
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Axin-SMAD3 complex
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Axin2-Ctnnb1-Apc complex
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AXL homodimer complex
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B-Ksr1-MEK-MAPK-14-3-3 complex
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B-raf-MAP3K11 complex
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B23-NPM3 complex
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BAD-BCL2xL complex
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Bad-Gk-Wave1-Pkaca-Ppp1cc complex
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BAF complex
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BANF1 homodimer protein
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BAR-BCL2-CASP8 complex
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BARD1-BRCA1-CSTF complex
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BARD1-BRCA1-CSTF64 complex
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BASC (Ab 80) complex (BRCA1-associated genome surveillance complex)
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BASC (Ab 81) complex (BRCA1-associated genome surveillance complex)
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BASC (Ab C-20) complex (BRCA1-associated genome surveillance complex)
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BASC complex (BRCA1-associated genome surveillance complex)
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Bash-Bnas2/Cmtm3-Btk-Erk2 complex
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BAX homo-oligomer complex
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Bax homooligomeric complex, after apoptotic stimulation
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BAX-BAK-IRE1alpha complex
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BCDX2 complex
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A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof.
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Bcl-xL-p53-PUMA complex, DNA damage induced
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BCL10 oligomer complex
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BCL10-CHUK-BCL10-IKBKB complex
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BCL10-MALT1 complex
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Bcl2 homodimer complex
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BCL6-HDAC4 complex
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BCL6-HDAC5 complex
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BCL6-HDAC7 complex
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BCL6-ZBTB17 complex
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BCOR complex
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BCR-ABL (p185 fusion protein)-GRB2 complex
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BCR-ABL (p210 fusion protein)-GRB2 complex
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BCR-ABL (p210 fusion protein)-GRB2-SOS1 complex
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beta(1)-AR receptosome (ADRB1-SAP97-AKAP79-PRKAR2A)
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Beta-dystroglycan-caveolin-3 complex
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BETA2-Cyclin D1 complex
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BHC complex
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BHC110 complex
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Binary COG subcomplex
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Bipartite complex (TFC4, CTNNB1)
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BIRC5-AURKB-INCENP-EVI5 complex
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Birc6 homodimer complex
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BKCA-beta2AR complex
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BKCA-beta2AR-AKAP79 signaling complex
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BLM complex II
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BLM complex III
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BLM-RAD51L3-XRCC2 complex
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BLM-TOP3A complex
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BLM-TRF2 complex
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BLOC-1 (biogenesis of lysosome-related organelles complex 1)
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BLOC-2 (biogenesis of lysosome-related organelles complex 2)
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BLOC-3 (biogenesis of lysosome-related organelles complex 3)
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BLOC1-BLOC2 complex
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BMI1-HPH1-HPH2 complex
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Bmi1-Mel18-Mph1-M33 polycomb repressor complex
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BMP2-BRIA complex
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BMP4-BGN complex
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BMP4-TWSG1 complex
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BNIP2-ARHGAP8 complex
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BP-SMAD complex
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BRAF-CNK1 complex, not RAS stimulated
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BRAF-MAP2K1-MAP2K2-YWHAE complex
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BRAF-RAF1-14-3-3 complex
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BRAF53-BRCA2 complex
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BRAFT complex
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Brain-derived dystrobrevin-syntrophin complex
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BRCA1 A complex
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A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites.
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BRCA1 B complex
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A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites.
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BRCA1 C complex
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A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint.
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BRCA1-BACH1 complex
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BRCA1-BARD1-BACH1-DNA damage complex I
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BRCA1-BARD1-BACH1-DNA damage complex II
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BRCA1-BARD1-BRCA2-DNA damage complex III
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BRCA1-BARD1-POLR2A complex
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BRCA1-BARD1-UbcH5c complex
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BRCA1-BARD1-UbcH7c complex
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BRCA1-cABL complex
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BRCA1-core RNA polymerase II complex
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BRCA1-CtIP-CtBP complex
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BRCA1-CTIP-ZBRK1 repressor complex
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BRCA1-HDAC1-HDAC2 complex
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BRCA1-IRIS-pre-replication complex
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BRCA1-LMO4-CTIP complex
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BRCA1-RAD50-MRE11-NBS1 complex
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BRCA1-RAD51 complex
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A protein complex that contains BRCA1 and Rad 51, and is involved in the control of recombination and of genome integrity.
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BRCA1-RNA polymerase II complex
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BRCA1-SMAD3 complex
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BRCA1-VCP complex
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BRCC complex
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BRD4 complex
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BRD4-P-TEFb complex
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BRD4-RFC complex
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BRG1-associated complex
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Brg1-associated complex I
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Brg1-associated complex II
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Brg1-based SWI/SNF chromatin remodeling complex
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BRG1-SIN3A complex
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BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I
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Brm-associated complex
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BRM-SIN3A complex
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BRM-SIN3A-HDAC complex
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BRMS1-RBP1 complex
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BRMS1-SIN3-HDAC complex
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BUB1-BUB3 complex
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Protein complex that associates with the kinetochores.
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C complex spliceosome
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C-CFTR-NHERF(PDZ1 domain)-ezrin complex
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C-CFTR-NHERF(PDZ2 domain)-ezrin complex
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c-MYC-ATPase-helicase complex
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c-Myc-Max-Arf complex
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c-Src-Muc1 complex
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C/EBPalpha-HNF6 complex
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C1D homodimer protein
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CACY homodimer complex
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CAK complex (Cdk-activating kinase complex)
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CAK core complex (Cdk-activating kinase core complex)
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CAK-ERCC2 complex
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A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2.
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CALM1-FKBP38-BCL2 complex
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Calreticulin oligomer complex
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CAMK2-delta-MASH1 promoter-coactivator complex
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CAND1-CUL1-RBX1 complex
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CAND1-CUL2-RBX1 complex
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CAND1-CUL3-RBX1 complex
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CAND1-CUL4A-RBX1 complex
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CAND1-CUL4B-RBX1 complex
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CAP(C)-CAP(E) complex
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Car-Jam3 complex
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Car-Lnx2 complex
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CARMA1-BCL10-MALT1 complex
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A protein complex comprising Carma1, Bcl10 and MALT1; plays a role in signal transduction during NF-kappaB activation.
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CAS-SRC-FAK complex
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Casein kinase II (beta-dimer, alpha'-dimer)
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Casein kinase II (beta-dimer, alpha, alpha')
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Casein kinase II (beta-dimer, alpha-dimer)
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Casein kinase II complex
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A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein.
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Casein kinase II-HMG1 complex
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Cask-Dlg1 complex
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CASK-LIN7C-APBA1 complex
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CASK-MINT complex
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CASP8-CHUK-IKBKB-MALT1-BCL10 complex
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CASP8-FADD-MALT1-BCL10 complex
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Caspase-2-TRAF2-RIP1 complex
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Catenin (alpha) - catenin (beta) complex
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Catulin (alpha) - catenin (beta) complex
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CAV1-VDAC1-ESR1 complex
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Caveolar macromolecular signaling complex
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A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3).
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Caveolar macromolecular signaling complex, using anti-Cav-3
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Caveolin-1 homodimer complex
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CBC complex (cap binding complex)
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CBF-DNA complex
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CBF1-HDAC1-SMRT complex
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Cbl-Cd2ap complex
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Cbl-Cd2ap-Flt1 complex
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Cbl-Crkl-Rapgef1 complex
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Cbl-SLP-76-Grb2 complex, Fc receptor gamma-R1 stimulated
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CBP-RARA-RXRA-DNA complex, ligand stimulated
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Ccd1-Axin complex
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Ccd1-Dvl2 complex
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Ccd1-Dvl2-Rac complex
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Ccd1-Mekk4 complex
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Ccna2-Cdk2 complex
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CCNB1-CDC2 complex
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CCNB2-CDC2 complex
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CCNC-CDK3 complex
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CCNC-CDK8-MED1-MED6-MED7 xcomplex
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CCND1-CDK4 complex
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CCND1-CDK6 complex
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CCND2-CDK4 complex
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CCND2-CDK6 complex
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CCND3-CDK4 complex
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CCND3-CDK6 complex
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CCT complex (chaperonin containing TCP1 complex)
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CCT complex (chaperonin containing TCP1 complex), testis specific
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CCT micro-complex
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CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)
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A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein.
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CD19-Vav-PI 3-kinase (p85 subunit) complex
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A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K).
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CD20-LCK-FYN-p75/80 complex
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CD20-LCK-LYN-FYN-p75/80 complex, (Raji human B cell line)
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Cd247 homodimer complex
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CD28-transactivation complex
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Cd2ap-Fyn complex
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Cd2ap-Synpo complex
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Cd3d-Cd3g-Cd3e-Cd247 complex
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Cd3e homodimer complex
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Cd3e-Nck1-Mink1 complex
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Cd3g-Cd3e complex
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Cd3g-Cd3e-Cd247-Canx complex
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Cd74-Cd44 receptor complex
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CD8A-LCK complex
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CD98-LAT2-ITGB1 complex
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CDC2-CCNA2 complex
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CDC2-CCNA2-CDK2 complex
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Cdc2-Ccnb1 complex
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CDC2-CCNB1-CCNF complex
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CDC2-CCNB1-PTCH1 complex
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CDC2-PCNA-CCNB1-GADD45A complex
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CDC2-PCNA-CCNB1-GADD45B complex
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CDC2-PCNA-CCNB1-GADD45G complex
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CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex
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CDC5L complex
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CDC5L core complex
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CDC7-DBF7 complex
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CDCA5-PDS5A-RAD21-SMC1A-PDS5B-SMC3 complex
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CDH1-CKS1B complex
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CDH1-SKP2 complex
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CDH23-harmonin transmembrane complex
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Cdh23-Myo1c complex
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CDK2-CCNA2 complex
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CDK2-CCNE1 complex
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CDK4-CCND1 complex
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Cdk5-c-Abl-Cables complex
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Cdk5-Cdk5r1-Pctk1 complex
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Cdk5/p35 complex (Cdk5-Cdk5r1 complex)
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CDK8-CyclinC-Mediator complex
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CDK8-MED6-PARP1 complex
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Cebpa-Smarca2 complex
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CEBPE-E2F1-RB1 complex
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Cell cycle kinase complex CDC2
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Cell cycle kinase complex CDK2
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Cell cycle kinase complex CDK4
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Cell cycle kinase complex CDK5
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Cell division cycle complex (CDC27, CDC16, ANAPC7)
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Cell-cell junction complex (ARHGAP10-CTNNA1)
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Cell-cell junction complex (CDH1-CTNNB1)
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CEN complex
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CENP-A NAC-CAD complex
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CENP-A nucleosome associated complex
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CERF complex (CECR2-containing remodeling factor complex)
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CF IIAm complex (Cleavage factor IIAm complex)
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CFTR-NHERF-beta(2)AR signaling complex
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Channel complex TRPM6-TRPM7
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Checkpoint 9-1-1 complex
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Checkpoint Rad complex
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CHL12-RFC2-5 complex
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CHL2-BMP2 complex
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CHL2-BMP2-TSG complex
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Chromatin assembly complex (CAF-1 complex)
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Chromatin remodeling complex (TACC2, TACC3, PCAF)
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Chromosomal passenger complex CPC (CDCA8, AURKB, BIRC5)
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Chromosomal passenger complex CPC (INCENP, BIRC5, AURKB)
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Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5)
|
|
Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB)
|
|
CHUK-ERC1-IKBKB-IKBKG
|
|
CHUK-IKBKB-IKBKG complex
|
|
CHUK-IKBKB-MAP3K14 complex
|
|
CHUK-IQGAP2-AKAP8L-RELA-TNIP2 complex
|
|
CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex
|
|
CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1)
|
|
CIN85 homotetramer complex
|
|
CIN85-BLNK complex
|
|
CIN85-c-CBL complex
|
|
CIN85-CBL complex
|
|
CIN85-CBL-SH3GL2 complex
|
|
CIN85-CBL-SH3GL2-EGFR complex, EGF stimulated
|
|
CIN85-SH3GL2 complex
|
|
CIN85-SH3GL3 complex
|
|
CIN85-SH3GL3-CBL complex
|
|
Class C Vps complex (VPS11, VPS18, STX7)
|
|
Class C Vps complex (VPS11, VPS18, VPS16)
|
|
Class C VPS/HOPS complex
|
|
Cleavage and polyadenylation factor (CPSF)
|
|
Cleavage stimulation factor
|
|
ClpP complex, heptameric
|
|
ClpX complex, hexameric
|
|
ClpXP complex
|
|
cMYC-ATPase-helicase complex
|
|
CNK1 homodimer complex
|
|
CNK1-SRC-RAF1 complex
|
|
CNS-P53 complex
|
|
CNTF-CNTFR-gp130-LIFR complex
|
|
Cofilin-actin-CAP1 complex
|
|
COG complex
|
A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p).
|
COG1-COG8 subcomplex
|
|
COG1-COG8-COG2-COG3-COG4 subcomplex
|
|
COG1-COG8-COG5-COG6-COG7 subcomplex
|
|
COG2-COG3-COG4 subcomplex
|
|
COG5-COG6-COG7 subcomplex
|
|
Cohesin complex, incomplete (Rec8, Crest/Ss18I1)
|
|
Cohesin complex, incomplete (Smc1b, Crest/Ss18I1)
|
|
Cohesin complex, incomplete (Smc1b, Sycp1, Crest/Ss18I1)
|
|
Cohesin complex, incomplete (Smc3, Sycp1, Crest/Ss18I1)
|
|
Cohesin complex, incomplete (Smc4, Crest/Ss18I1)
|
|
Cohesin complex, incomplete (Stag3, Crest/Ss18I1)
|
|
Cohesin complex, incomplete (Stag3, Scp1, Ss181)
|
|
Cohesin complex, incomplete (Stag3, Sycp3)
|
|
Cohesin complex, incomplete (Sycp1, Crest/Ss18I1, Rec8)
|
|
Cohesin complex, incomplete (Sycp2, Crest/Ss18I1)
|
|
Cohesin-SA1 complex
|
|
Cohesin-SA2 complex
|
|
Complexin complex (STX3, CPLX1, CPLX3)
|
|
Condensin I complex
|
|
Condensin I-PARP-1-XRCC1 complex
|
|
Condensin II
|
|
Conserved oligomeric Golgi (COG) complex
|
|
COP9 signalosome complex
|
|
COP9 signalosome complex (Gps1, Cops1, Cops2, Cops3, Cops4, Cops5, Cops6, Cops7a, Cops7b, Cops8)
|
|
CoREST-HDAC complex
|
|
CoREST-HDAC2 complex
|
|
COX1 homodimer complex
|
|
CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex
|
|
CPSF6-ITCH-NUDT21-POLR2A complex
|
|
CPSF6-ITCH-NUDT21-POLR2A-UBAP2L complex
|
|
CRB1-MPP5-INADL complex
|
|
Crb1-Mupp1-Pals1-Mpp4 complex
|
|
CREBBP-SMAD2 hexameric complex
|
|
CREBBP-SMAD2-SMAD4 pentameric complex
|
|
CREBBP-SMAD3 hexameric complex
|
|
CREBBP-SMAD3-SMAD4 pentameric complex
|
|
cRET-Shc-Grb2-Gab2-P85PI3K-Shp2 complex
|
|
CRK-BCAR1-DOCK1 complex
|
|
CRKII-C3G complex
|
|
CRKL-PDGFRA-CRK-RAPGEF1 complex
|
|
CRKL-WIPF1-WAS complex
|
|
CRLR-RAMP1 complex
|
|
CRLR-RAMP2 complex
|
|
CRLR-RAMP3 complex
|
|
CRM1-RAN-PHAX-CBC complex (cap binding complex)
|
|
CRM1-Survivin mitotic complex
|
|
CRM1-Survivin-AuroraB mitotic complex
|
|
CRMP-MICAL-PlexinA1 complex, induced by SEMA3A
|
|
CRSP complex
|
|
CRSP-Mediator 2 complex
|
|
CS-MAP3K7IP1-MAP3K7IP2 complex
|
|
CSA complex
|
|
CSA-POLIIa complex
|
|
CSK-GAP-A.p62 complex
|
A protein complex that contains the protein-tyrosine kinase CSK and the GTPase-activating protein (GAP)-associated p62 (GAP-A.p62); may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation.
|
CtBP complex
|
|
CtBP core complex
|
|
CTCF-nucleophosmin complex
|
|
CTCF-nucleophosmin-PARP-HIS-KPNA-LMNA-TOP complex
|
|
CTF18-cohesion-RFC complex
|
|
CTF18-cohesion-RFC-POLH complex
|
|
CTF18-CTF8-DCC1 complex
|
|
CTF18-CTF8-DCC1-RFC3 complex
|
|
CTF18-RFC subcomplex
|
|
CTF8-CTF18-DCC1 subcomplex
|
|
CTF8-DCC1 subcomplex
|
|
CTFC-TAF1 complex
|
|
CTGF/Hcs24-actin complex
|
|
CTLH complex
|
|
CycD1-Cdk4 complex
|
|
Cyclin D1-associated protein complex
|
|
CyclinA2-Cdk2 complex
|
A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
|
CyclinB1-Cdc2 complex
|
|
CyclinD1-CDK4-CDK6 complex
|
|
CyclinD3-CDK4-CDK6 complex
|
|
CyclinD3-CDK4-CDK6-p21 complex
|
|
Cytochrome bc1-complex (EC 1.10.2.2), mitochondrial
|
|
Cytochrome c oxidase (EC 1.9.3.1), mitochondrial
|
|
Cytosolic multicomponent signaling complex, anti-CD40 stimulated, (Ikbkg, Map3k1, Traf2, Ube2n)
|
|
DA complex
|
|
DAB complex
|
|
DAP12 signaling homodimer complex
|
|
DAXX-AXIN complex
|
|
Daxx-Axin-p53 complex
|
|
DAXX-Axin-p53-HIPK2 complex
|
|
DAXX-DNMT1-DMAP1 complex
|
|
DCP1A-DCP2 Decapping complex
|
|
DCS complex (PTBP1, PTBP2, HNRPH1, HNRPF)
|
|
DDB complex
|
|
DDB2 complex
|
|
DDEF1-CTTN-PXN complex
|
|
Death induced signaling complex DISC (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced
|
|
Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced
|
|
Death-inducing signaling complex DISC (type I cells associated), stimulated
|
|
Decapping complex
|
|
Delta1 homodimer complex
|
A protein complex that consists of homodimer of the Notch ligand Delta1.
|
DGCR8 multiprotein complex
|
|
DGCR8-ILF3 complex
|
|
DGCR8-NCL complex
|
|
DHX9-ADAR-vigilin-DNA-PK-Ku antigen complex
|
|
DICER1-NCOA6-AGO2 complex
|
|
DIPA-MCRS1 complex
|
|
DJ-1-SNCA complex, high molecular weight complex
|
|
DLP1-hFIS1 complex
|
|
DMAP1-associated complex
|
|
DNA double-strand break end-joining complex
|
|
DNA ligase III-XRCC1 complex
|
A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair.
|
DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex
|
|
DNA ligase IV-condensin complex
|
|
DNA ligase IV-XRCC1 complex
|
|
DNA ligase IV-XRCC4 complex
|
A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p.
|
DNA ligase IV-XRCC4 complex (LX complex)
|
|
DNA ligase IV-XRCC4-AHNK complex
|
|
DNA ligase IV-Xrcc4-DNA-protein kinase complex
|
|
DNA ligase IV-XRCC4-PNK complex
|
|
DNA ligase IV-XRCC4-XLF complex
|
|
DNA polymerase alpha
|
|
DNA polymerase alpha-primase complex
|
|
DNA polymerase delta complex
|
|
DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1
|
|
DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1
|
|
DNA synthesome complex
|
A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.
|
DNA synthesome complex (13 subunits)
|
|
DNA synthesome complex (15 subunits)
|
|
DNA synthesome complex (17 subunits)
|
|
DNA synthesome core complex
|
|
DNA-PK-Ku antigen complex
|
A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku.
|
DNA-PK-Ku complex
|
|
DNA-PK-Ku-eIF2-NF90-NF45 complex
|
|
DNAJB2-HSPA8-PSMA3 complex
|
|
DNMT1-G9a complex
|
|
DNMT1-G9a-PCNA complex
|
|
DNMT1-RB1-HDAC1-E2F1 complex
|
|
DNMT3B complex
|
|
DNMT3B-DNMT3L complex
|
|
DNMT3L-DNMT3A complex
|
|
Dok1-Map4k4-Nck1-Rasa1 complex
|
|
Dolichol-phosphate mannose (DPM) synthase
|
|
DRIP complex
|
|
DRIP78-PHLP complex
|
|
Drosha complex
|
|
DSIF complex (DRB sensitivity-inducing factor complex)
|
|
DSS1 complex
|
|
Dvl2-Rac complex
|
|
Dysbindin-pallidin-muted-beta-dystrobrevin complex
|
|
Dysferlin-affixin complex
|
|
Dystrophin-sarcoglycan-syntrophin complex, skeletal muscle
|
|
E-box sequence-binding complex
|
|
E2F-6 complex
|
|
E2F1-p107-cyclinA complex
|
|
E2F1-Rb complex
|
|
E2F4-p107-cyclinA complex
|
|
E2F4-p107-cyclinE complex
|
|
E2F4-p130 complex
|
|
E2F5-RB2-DP1 complex
|
|
E2f5-Rbl2-Hdac1 complex
|
|
EB1-APC-mDia1 complex
|
|
EB1-APC-mDia2 complex
|
|
EBAFa complex
|
|
EBAFb complex
|
|
Ecsit complex (ECSIT, MT-CO2, GAPDH, TRAF6, NDUFAF1)
|
|
Ecsit complex (ECSIT, MT-CO2, NDUFA1, MT-ND1, TRAF6, NDUFAF1)
|
|
Ecsit complex (ECSIT, NDUFS3, NDUFAF1)
|
|
Ecsit complex (ECSIT, NDUFS3, TOM20)
|
|
Ecsit complex (Ecsit2-Smad1)
|
|
Ecsit complex (Ecsit2-Smad4)
|
|
Ecsit complex (Smad1-Smad4-Ecsit2)
|
|
Ectodermin-SMAD4 complex
|
|
EDG1-HTR1D complex
|
|
EED-EZH polycomb complex
|
|
EED-EZH-YY1 polycomb complex
|
|
EED-EZH2 complex
|
|
Egasyn-glucuronidase complex
|
|
EGFR-CBL-GRB2 complex
|
|
EGFR-containing signaling complex
|
|
Egfr-Grb2-mSos1 complex, EGF stimulated
|
A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
|
EGR-EP300 complex
|
|
EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C)
|
|
EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3J)
|
|
EIF3 complex (EIF3B, EIF3G, EIF3I)
|
|
EIF3 complex (EIF3B, EIF3J, EIF3I)
|
|
eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7)
|
|
eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1)
|
|
EIF3 core complex (EIF3A, EIF3B, EIF3G, EIF3I)
|
|
eIF4AIII-Btz complex
|
|
ELK1-SRF-ELK3 complex
|
|
ELK1-SRF-ELK4 complex
|
|
ELMO1-DOCK1 complex
|
|
ELMO1-DOCK1-CRKII complex
|
|
ELMO1-DOCK1-RAC1 complex
|
|
ELMO1-DOCK2 complex
|
|
Elongator core complex
|
A heterohexameric protein complex that is involved in modification of wobble nucleosides in tRNA, and exerts direct effects on transcriptional elongation and exocytosis. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes.
|
Elongator holo complex
|
|
Emerin architectural complex
|
|
Emerin complex 1
|
|
Emerin complex 24
|
|
Emerin complex 25
|
|
Emerin complex 32
|
|
Emerin complex 52
|
|
Emerin regulatory complex
|
|
Emerin-actin-NMI complex
|
|
Emerin-actin-NMI-(alphaII)spectrin complex
|
|
Endoglin homodimer complex
|
|
eNOS-CAV1 complex
|
|
eNOS-HSP90 complex, VEGF induced
|
|
eNOS-HSP90-AKT complex, VEGF induced
|
|
EPO-EPOR complex
|
|
Epo-R-IP(3)R type II-TRPC2 complex
|
|
Epo-R-PLC-gamma 1-IP(3)R type II-TRPC2 signaling complex
|
|
Epo-R-PLC-gamma-TRPC2 complex
|
|
EPOR receptor complex
|
|
Eps15-stonin2 complex
|
|
ER-alpha-c-Jun complex
|
|
ER-alpha-GRIP1-c-Jun complex
|
|
Er-alpha-p53-hdm2 complex
|
|
ERAP1-ERAP2 complex
|
|
ERBB2-MEMO-SHC complex
|
|
ERCC1-ERCC4-MSH2 complex
|
|
ERCC2/CAK complex
|
|
ERdj3-BiP complex
|
|
eRF1-eRF3-GTP-Mg(2+) complex
|
|
ERG-JUN-FOS DNA-protein complex
|
|
ESCRT-I complex
|
An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.
|
ESCRT-II complex
|
An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes.
|
ESCRT-III complex
|
An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes.
|
ESPL1-CDC2 complex
|
|
ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex
|
|
ESR1-RELA-BCL3-NCOA3 complex
|
|
ETS2-ERG complex
|
|
ETS2-ETS1 complex
|
|
ETS2-FOS-JUN complex
|
|
Ets2-Ini1-Smarce1-Smarca4 complex
|
|
ETS2-SMARCA4-INI1 complex
|
|
Ets2-Smarca4-Smarcb1-Smarce1 complex
|
|
EXO1-MLH1-PCNA complex
|
|
EXO1-MLH1-PMS2 complex
|
|
Exon junction complex
|
|
Exon junction complex (EIF4A3-MLN51-MAGOH-Y14)
|
|
Exon junction complex (EIF4A3-MLN51-MAGOH-Y14), RNA-protein complex
|
|
Exon junction complex (EIF4A3-MLN51-UPF3B-MAGOH-Y14)
|
|
Exon junction complex (F4A3-MLN51-UPF3B-MAGOH-Y14-PYM)
|
|
Exon junction complex (mRNA splicing-dependent)
|
|
Exon junction complex, EIF4A3-MLN51-MAGOH-Y14 (RNA-protein complex)
|
|
Exosome
|
|
Eya1/3-Dach1/2-Six1 complex
|
|
F1F0-ATP synthase (EC 3.6.3.14), mitochondrial
|
|
FA complex (Fanconi anemia complex)
|
|
FA complex (Fanconi anemia complex), cytoplasmic
|
|
FA core complex (Fanconi anemia core complex)
|
|
FA core complex 1 (Fanconi anemia core complex 1)
|
|
FACT complex
|
An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer.
|
FACT complex, UV-activated
|
|
FACT-NEK9 complex
|
|
FAK-beta5 integrin complex, VEGF induced
|
|
Farnesyltransferase
|
|
FARP2-NRP1-PlexinA1 complex
|
|
FARP2-NRP1-PlexinA2 complex
|
|
FARP2-NRP1-PlexinA3 complex
|
|
FARP2-NRP1-PlexinA4 complex
|
|
FAS-FADD-CASP10 complex
|
|
FAS-FADD-CASP8 complex
|
|
FAS-FADD-CASP8-CASP10 complex
|
|
FCP1-associated protein complex
|
|
FE65-TSHZ3-HDAC1 complex
|
|
FEN1-9-1-1 complex
|
|
Fertilin complex (Adam1a, Adam2)
|
|
Fertilin complex (Adam1b, Adam2)
|
|
Fgf2-Ck2 complex
|
|
Fgf2-Rsk2 complex
|
|
FGFR2-c-Cbl-Lyn-Fyn complex
|
|
Fgr-Pyk2-p190RhoGap complex
|
|
FHL2 homodimer complex
|
|
FHL2-ACT complex
|
|
FHL2-CREB complex
|
A protein complex that contains CREB and FHL2, and is involved in transcriptional regulation.
|
FHL2-FHL3 complex
|
|
FHL2-p53-HIPK2 complex
|
|
FHL3 homodimer complex
|
|
FHL3-CREB complex
|
A protein complex that contains CREB and FHL3, and is involved in transcriptional regulation.
|
FHL4/STX11-ACT complex
|
|
FIB-associated protein complex
|
|
FIF-FGR2 complex
|
|
FKBP12-FK506 complex
|
|
Fmrp-Lgl complex
|
|
FN1-TGM2 complex
|
|
Foxh1-Nkx2-5 complex
|
|
FOXO1-FHL2-SIRT1 complex
|
|
FOXO3-PCAF complex, oxidative stress stimulated
|
|
FOXO3-SIRT1 complex, oxidative stress stimulated
|
|
FOXO3-TP53 complex, oxidative stress stimulated
|
|
Foxo4-Srf-Myocd complex
|
|
Frs2-Grb2-Shp2 complex, FGF stimulated
|
|
Frs2-Shp2 complex, FGF stimulated
|
|
FYB-CARMA1-BCL-10-MALT1 complex
|
|
G protein complex (BTK, GNG1, GNG2)
|
A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein.
|
G protein complex (Btk, Gng2, Gnb1)
|
A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein.
|
G protein complex (CACNA1A, GNB1, GNG2)
|
|
G protein complex (GNG2, GNB2L1, RAF1)
|
A protein complex formed by the association of the serine-threonine protein kinase Raf-1 with the beta and gamma subunits of a heterotrimeric G protein.
|
G protein complex (Gngt2, Kcnj3, Gnb1)
|
|
G protein complex (Gngt2, Kcnj6, Gnb1)
|
|
G protein complex (HDAC4, GNB1, GNG2)
|
|
G protein complex (HDAC5, GNB1, GNG2)
|
|
G protein complex (MCF2, GNB1, GNG2)
|
|
G protein complex (PTHR1, GNB1, GNG2)
|
|
GAA1-GPI8-PIGT-PIG-PIGS complex
|
|
GABAA receptor
|
|
GABBR2-HTR1A complex
|
|
GABP(gamma)1-E2F1-DP1 complex
|
|
GAIT complex
|
A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP.
|
GALNS-lysosomal hydrolase 1.27 MDa complex
|
A protein complex found in the lysosome that contains beta-galactosidase, cathepsin A, alpha-neuraminidase and N-acetylgalactosamine-6-sulfate sulfatase, and is involved in glycosaminoglycan catabolism.
|
Gamma-BAR-AP1 complex
|
|
Gamma-secretase complex (Aph1a, Ncstn, Psen1, Psenen, Tmp21)
|
|
Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant)
|
A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein.
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Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN)
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Gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)
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A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein.
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Gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)
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Gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)
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A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein.
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Gamma-secretase-Delta1 complex
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A protein complex that is formed by the association of the Notch ligand Delta1 with the gamma-secretase complex.
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GammaH2AFX-NDHII-Ku70-DNA complex
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Gata1-Fog1 complex
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Gata1-Fog1-MeCP1 complex
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Gata1-Gfi1b complex
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Gata1-Ldb1-Tal1 complex
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Gata1-Snf2h complex
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Gata1-Tal1-Tcf3-Lmo2 complex
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A protein complex that contains the zinc finger transcription factor GATA1, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis.
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Gata2-Tal1-Tcf3-Lmo2 complex
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A protein complex that contains the zinc finger transcription factor GATA2, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis.
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GCN5-TRRAP histone acetyltransferase complex
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GINS complex
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A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks.
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GIPC1-LHCGR complex
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GIPC1-NTRK1-RGS19 complex
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Girdin homo-oligomer complex
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GLE1-NUPL2-NUP155 complex
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GluR delta-2 complex, postsynaptic (GluR delta-2, Shank1, Shank2, mGluR1 alpha, Homer, PSD-95)
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GluR6a-GluR6b-KA2 complex
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GNA14-p115RhoGEF complex
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GNAQ-GEFT-RHOA complex
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gp78-p97/VCP-DERL1 complex
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GPI-GnT activity complex
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GPR56-CD81-Galphaq/11-Gbeta complex
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GR-hnRNP U complex
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Grancalcin-sorcin complex
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GRASP-GRP1 complex
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Grb2-Lab-Blnk complex, BCR stimulated
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Grb2-mSos1 complex
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A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
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GRB2-SHP-2 complex, PDGF stimulated
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A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway.
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Grb2-Shp2 complex, FGF stimulated
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Grb2-Sos complex, Fc receptor gamma-R1 stimulated
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Grin2a-Lrp8 complex
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Grin2b-Lrp8 complex
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GTP-Rho-Rhpn1-Ropn1 complex
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Guanylyl cyclase, soluble (GUCY1A2, GUCY1B3)
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Guanylyl cyclase, soluble (GUCY1A3, GUCY1B3)
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H2AX complex I
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H2AX complex II
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H2AX complex, isolated from cells without IR exposure
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hASC-1 complex
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HBO1 complex
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HCF-1 complex
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HD-RAB8A-OPTN complex
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HDAC1-associated core complex cI
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HDAC1-associated core complex cII
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HDAC1-associated protein complex
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Hdac1-Mecp2-Rcor1-Sin3a complex
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HDAC2-asscociated core complex
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HDAC4-ERK1 complex
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HDAC4-ERK2 complex
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HERP1/HEY2-NCOR-SIN3A complex
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HES1 promoter corepressor complex
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HES1 promoter-Notch enhancer complex
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HESX1-TLE1 complex
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Heterodimer complex (CDK9, IL6ST)
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Heterotrimeric complex (CCNT1, CDK9, GRN)
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Heterotrimeric G protein complex (GNG2, GNB1, GNAS)
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Heterotrimeric SKP1-CUL1-ROC1 complex
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HGF-Met complex
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HIF1A-OS9-EGLN1 complex
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HIF1A-OS9-EGLN3 complex
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Hip1R-cortactin complex
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Histone H3.1 complex
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Histone H3.3 complex
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hMediator complex (MED23, CDK8, CCNC)
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hMediator complex (MED23, CDK8, CCNC, MED7)
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HMGB1-HMGB2-HSC70-ERP60-GAPDH complex
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Hnf4-Pc4 complex
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HNF4A-SUB1 complex
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HNRPF-HNRPH1 complex
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hNURF complex
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Homodimeric complex LTBR
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Homotetrameric complex NIAP
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Hop2-Mnd1 complex
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HPFH(-198) complex
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hPRC1L complex
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hRAD51C-hXRCC3 complex
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hs4 enhancer complex (faster migrating complex)
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hs4 enhancer complex (slow migrating complex)
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HSF1-HSF2 complex
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HSF1-YWHAE complex
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hSIR2-p53 complex
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Hsp110-Hsc70-Hsp25 complex
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HSP70-BAG5-PARK2 complex
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HSP90-CDC37-LRRK2 complex
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HSP90-CIP1-FKBPL complex
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HSP90-FKBP38-CAM-Ca(2+) complex
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HTR1A homodimer complex
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HTR1A-EDG1 complex
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HTR1A-EDG3 complex
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HTR1A-GPR26 complex
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HTR1A-HTR1B complex
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HTR1A-HTR1D complex
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HTR1B homodimer complex
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HTR1D homodimer complex
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HTR1D-HTR1B complex
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Htt-Dctn1-Hap1 complex
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HuCHRAC complex
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HUIC complex
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I(kappa)B(alpha)-NF(kappa)Bp50-NF(kappa)Bp65 complex
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I-kappa-B kinase (IKK) complex
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IFNB1-IFNAR1-IFNAR2- complex
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IFP35-NMI complex
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IGF1-IGFBP3-ALS complex
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IGHM-VPREB1-IGLL1 complex
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IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14)
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Ikaros complex
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Ikaros-NuRD complex
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IKB(alpha)-RELA-cREL complex
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IKB(beta)-RELA-cREL complex
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IKB(epsilon)-RELA-cREL complex
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IKBA-NF(kappa)Bp65-NF(kappa)Bp50 complex
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IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex
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IKBKG homodimer complex
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IKBKG homotrimer complex
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IKBKG tetramer complex
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IKBKG-CHUK complex
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IKBKG-IKBKB complex
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IKK-alpha--ER-alpha-AIB1 complex
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IKKA-IKKB complex
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IKKB-NIK complex
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IL-12 heterodimer complex
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IL-12 subunit p40 homodimer complex
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IL12A homodimer complex
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IL12A-IL12B complex
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IL12A-IL12B-IL12RB1 complex
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IL12A-IL12B-IL12RB2 complex
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IL12B-IL12RB1-IL12RB2 complex
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IL12RB1-IL12RB2 complex
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IL2-IL2RA-IL2RB complex
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Il3rb1-Shc complex, IL-3 stimulated
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Il3rb1-Shc-Ship complex, IL-3 stimulated
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IL4-IL4R complex
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IL4-IL4R-IL2RG complex
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IL6ST-PRKCD-STAT3 complex
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ILF3-XPO5 complex
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ILK-PARVB-ARHGEF6 complex
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immunoproteasome
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IMP3-IMP4-MPP10 complex
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ING1-p300-PCNA complex
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ING1-PCNA complex
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ING2 complex
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ING4 complex (ING4, MYST2, C1orf149, PHF15)
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ING4 complex (ING4, MYST2, C1orf149, PHF16)
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ING4 complex (ING4, MYST2, C1orf149, PHF17)
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ING5 complex
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INO80 chromatin remodeling complex
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A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity.
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InsP3R1-HAP1A-Htt complex
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Integrator complex
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A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II.
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Integrator-RNAPII complex
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Interferon-stimulated gene factor 3 transcription complex ISGF3
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IPO13-RAN-EIF1AX complex
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IPO13-RBM8A-MAGOH complex
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IRAK1-IRAK2 complex
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IRAK1-IRAK3 complex
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IRF3-CBP complex
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Isl1-Jak1-Stat3 complex
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Isocitrate dehydrogenase, cytoplasmic
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ITAGV-ITGB3-F11R complex
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ITCH-FAM/USP9x complex
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Itga-Itgb1-Ppap2b complex
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ITGA1-ITGB1-COL6A3 complex
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A protein complex that consists of an alpha1-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.
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ITGA1-ITGB1-PTPN2 complex
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A protein complex that consists of an alpha1-beta1 integrin complex bound to tyrosine-protein phosphatase non-receptor type 2.
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ITGA10-ITGB1 complex
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ITGA11-ITGB1 complex
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ITGA11-ITGB1-COL1A1 complex
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A protein complex that consists of an alpha11-beta1 integrin complex bound to a type I collagen.
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ITGA2-ITGB1 complex
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ITGA2-ITGB1-CD47 complex
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A protein complex that consists of an alpha2-beta1 integrin complex bound to the cell surface protein CD47.
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ITGA2-ITGB1-CHAD complex
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A protein complex that consists of an alpha2-beta1 integrin complex bound to the cartilage matrix protein chondroadherin.
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ITGA2-ITGB1-COL6A3 complex
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A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.
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ITGA2B-ITGB3 complex
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ITGA2b-ITGB3-CD47-FAK complex
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A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK.
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ITGA2b-ITGB3-CD47-SRC complex
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A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src.
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ITGA2b-ITGB3-CD9 complex
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A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface protein CD9.
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ITGA2b-ITGB3-CD9-GP1b-CD47 complex
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A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface proteins CD9 and CD47, and the heterodimeric platelet glycoprotein Ib.
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ITGA2B-ITGB3-CIB1 complex
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A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin.
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ITGA2B-ITGB3-F11R complex
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ITGA2B-ITGB3-FN1-TGM2 complex
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A protein complex that consists of an alphaIIb-beta3 integrin complex bound to fibronectin and tissue transglutaminase.
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ITGA2B-ITGB3-ICAM4 complex
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ITGA2b-ITGB3-TLN1 complex
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A protein complex that consists of an alphaIIb-beta3 integrin complex bound to talin.
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ITGA3-ITGB1 complex
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ITGA3-ITGB1-BSG complex
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A protein complex that consists of an alpha3-beta1 integrin complex bound to the cell surface protein basigin.
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ITGA3-ITGB1-CD151 complex
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A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD151.
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ITGA3-ITGB1-CD63 complex
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A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD63.
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ITGA3-ITGB1-THBS1 complex
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A protein complex that consists of an alpha3-beta1 integrin complex bound to thrombospondin.
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ITGA4-ITGB1 complex
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Itga4-Itgb1-Adam2 complex
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ITGA4-ITGB1-CD47 complex
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ITGA4-ITGB1-CD53 complex
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A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family.
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ITGA4-ITGB1-CD63 complex
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A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD63, a member of the tetraspan family.
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ITGA4-ITGB1-CD81 complex
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A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD81, a member of the tetraspan family.
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ITGA4-ITGB1-EMILIN1 complex
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ITGA4-ITGB1-JAM2 complex
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A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell adhesion molecule JAM2.
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ITGA4-ITGB1-THBS1 complex
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A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-1.
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ITGA4-ITGB1-THBS2 complex
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A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-2.
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ITGA4-ITGB1-VCAM1 complex
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ITGA4-PXN-GIT1 complex
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ITGA5-ITGB1-ADAM15 complex
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ITGA5-ITGB1-CAL4A3 complex
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A protein complex that consists of an alpha5-beta1 integrin complex bound to endostatin, the NC1 domain of the alpha1 chain of type XVIII collagen.
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ITGA5-ITGB1-FN-1-NOV complex
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A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and the extracellular matrix protein NOV.
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ITGA5-ITGB1-FN1-TGM2 complex
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A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and tissue transglutaminase.
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ITGA5-ITGB1-SPP1 complex
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A protein complex that consists of an alpha5-beta1 integrin complex bound to osteopontin.
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ITGA5-ITGB3-COL6A3 complex
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ITGA5-ITGB4 complex
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ITGA6-ITGB1 complex
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ITGA6-ITGB1-CD151 complex
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A protein complex that consists of an alpha6-beta1 integrin complex bound to the tetraspanin CD151.
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ITGA6-ITGB1-CYR61 complex
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A protein complex that consists of an alpha6-beta1 integrin complex bound to CYR61, a cysteine-rich protein involved in angiogenesis.
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ITGA6-ITGB4 complex
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ITGA6-ITGB4-CD151 complex
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A protein complex that consists of an alpha6-beta4 integrin complex bound to the tetraspanin CD151.
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ITGA6-ITGB4-CD9 complex
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A protein complex that consists of an alpha6-beta4 integrin complex bound to the cell surface protein CD9.
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ITGA6-ITGB4-FYN complex
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A protein complex that consists of an alpha6-beta4 integrin complex bound to the Src family tyrosine kinase Fyn.
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ITGA6-ITGB4-LAMA5 complex
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A protein complex that consists of an alpha6-beta4 integrin complex bound to laminin 5.
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ITGA6-ITGB4-Laminin10/12 complex
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ITGA6-ITGB4-SHC1-GRB2 complex
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ITGA7-ITGB1-CD151 complex
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A protein complex that consists of an alpha7-beta1 integrin complex bound to the tetraspanin CD151.
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ITGA7-ITGB1-CD9 complex
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ITGA7-ITGB1-ITGB1BP3 complex
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A protein complex that consists of an alpha7-beta1 integrin complex bound to nicotinamide riboside kinase 2 (also known as muscle integrin binding protein, MIBP).
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ITGA8-ITGB1 complex
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ITGA9-ITGB1-ADAM12 complex
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A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM12.
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ITGA9-ITGB1-ADAM15 complex
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A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM15.
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ITGA9-ITGB1-ADAM8 complex
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A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8.
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ITGA9-ITGB1-ADAM9 complex
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A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM9.
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ITGA9-ITGB1-FIGF complex
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A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor D.
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ITGA9-ITGB1-SPP1 complex
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A protein complex that consists of an alpha9-beta1 integrin complex bound to osteopontin.
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Itga9-Itgb1-Thbs1 complex
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A protein complex that consists of an alpha9-beta1 integrin complex bound to thrombospondin-1.
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ITGA9-ITGB1-TNC complex
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A protein complex that consists of an alpha9-beta1 integrin complex bound to the extracellular matrix protein tenascin.
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ITGA9-ITGB1-VCAM1 complex
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A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular cell adhesion molecule-1.
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ITGA9-ITGB1-VEGFA complex
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A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor A.
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ITGA9-ITGB1-VEGFC complex
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A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor C.
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ITGAE-ITGB7-CDH1 complex
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A protein complex that consists of an alphaE-beta7 integrin complex bound to E-cadherin.
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ITGAM-ITGB2-CD11 complex
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ITGAV-ITGB1 complex
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ITGAV-ITGB1-SPP1 complex
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A protein complex that consists of an alphav-beta1 integrin complex bound to osteopontin.
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ITGAV-ITGB3 complex
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ITGAV-ITGB3-ADAM15 complex
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A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM15.
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ITGAV-ITGB3-ADAM23 complex
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A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM23.
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ITGAV-ITGB3-CD47-FCER2 complex
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ITGAV-ITGB3-COL4A3 complex
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A protein complex that consists of an alphaV-beta3 integrin complex bound to tumstatin, the NC1 domain of the alpha3 chain of type IV collagen.
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ITGAV-ITGB3-EGFR complex
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A protein complex that consists of an alphaV-beta3 integrin complex bound to epidermal growth factor receptor.
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Itgav-Itgb3-Gsn complex
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A protein complex that consists of an alphaV-beta3 integrin complex bound to gelsolin.
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ITGAV-ITGB3-LAMA4 complex
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A protein complex that consists of an alphaV-beta3 integrin complex bound to laminin alpha-4.
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ITGAV-ITGB3-NOV complex
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ITGAV-ITGB3-PPAP2b complex
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A protein complex that consists of an alphaV-beta3 integrin complex bound to lipid phosphate phosphohydrolase-3.
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ITGAV-ITGB3-PXN-PTK2b complex
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A protein complex that consists of an alphaV-beta3 integrin complex bound to paxillin and the FAK-related kinase Pyk2.
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ITGAV-ITGB3-SLC3A2 complex
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A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface antigen CD98.
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ITGAV-ITGB3-SPP1 complex
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A protein complex that consists of an alphav-beta3 integrin complex bound to osteopontin.
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ITGAV-ITGB3-THBS1 complex
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A protein complex that consists of an alphav-beta3 integrin complex bound to thrombospondin.
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ITGAV-ITGB5 complex
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ITGAV-ITGB5-ADAM9 complex
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ITGAV-ITGB5-CYR61 complex
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ITGAV-ITGB5-ICAM4 complex
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ITGAV-ITGB5-PLAUR complex
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ITGAV-ITGB5-SPP1 complex
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A protein complex that consists of an alphav-beta5 integrin complex bound to osteopontin.
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ITGAV-ITGB6 complex
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ITGAV-ITGB6-SPP1 complex
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A protein complex that consists of an alphaV-beta6 integrin complex bound to osteopontin.
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ITGAV-ITGB6-TGFB3 complex
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ITGAV-ITGB8-MMP14-TGFB1 complex
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A protein complex that consists of an alphaV-beta8 integrin complex bound to matrix metalloproteinase 14 and transforming growth factor beta-1 (TGFbeta-1).
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ITGAV-P2RY2-GNA12 complex
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Itgax-Itgb2-Icam4 complex
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A protein complex that consists of an alphaX-beta2 integrin complex bound to intercellular adhesion molecule 4.
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ITGB1-ITGA9 complex
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ITGB1-NRP1 complex
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ITGB1-RAP1A-PKD1 complex
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Itgb1-Rap1a-Prkd1 complex
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ITGB3-ITGAV-CD47 complex
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A protein complex that consists of an alphav-beta3 integrin complex bound to CD47 (also known as IAP).
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ITGB3-ITGAV-VTN complex
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ITGB5-ITGAV-VTN complex
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ITGB6-FYN-FN1 complex
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ITK-SLP-76 complex, anti-TCR stimulated
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JAK2-IL12RB2 complex
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JBP1-pICln complex
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JUN-TCF4-CTNNB1 complex
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Junb-Sumo1 complex
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JUND-FOSB-SMAD3-SMAD4 complex
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Kaiso-NCOR complex
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KCNQ1 macromolecular complex
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Keap1-Nrf2-Cul3 complex
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Kif13a-AP1 complex
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Kif17-Lin10 complex
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Kif17-Lin10-Lin2-Lin7-NR2B complex
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Kif3-cadherin-catenin complex
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KIN17-PCNA-RPA70 complex
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Kinase maturation complex 1
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Kinase maturation complex 2
|
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Kinase-scaffold-phosphatase complex, PKA-AKAP79-CaN
|
|
Kir3.2 homotetramer complex
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|
Kir4.1-alpha-1-syntrophin complex, cortical astrocytes
|
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Kir4.1-alpha-1-syntrophin complex, whole brain lysate
|
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Kir4.1-beta-dystroglycan complex, cortical astrocytes
|
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Kir4.1-beta-dystroglycan complex, whole brain lysate
|
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Kir4.1-dystrophin complex, cortical astrocytes
|
|
Kir4.1-dystrophin complex, whole brain lysate
|
|
Kir6.2-Sur1 complex
|
|
KLC1-nKHC-uKHC kinesin complex
|
|
KLC2-nKHC-uKHC kinesin complex
|
|
Klf5-Pias1 complex
|
|
Kpna2-Kpnb1 complex
|
|
Ksr1 complex (Ksr1, Mek, 14-3-3), unstimulated
|
|
Ksr1 complex (Ksr1, Mek, 14-3-3, Mapk), EGF stimulated
|
|
KSR1 homooligomer complex
|
|
KSR1-BRAF-MEK complex
|
|
Ksr1-CK2 complex
|
|
Ksr1-CK2-MEK-14-3-3 complex, PDGF treated
|
|
Ksr1-Mek-Braf complex, EGF induced
|
|
Ksr1-Mek-Braf-Erk complex, EGF induced
|
|
Ksr1-PP2A core enzyme complex (Ppp2r1a, Ppp2ca), untreated
|
|
Ksr1-PP2A holoenzyme complex (Ppp2r1a, Ppp2r2b, Ppp2ca), PDGF stimulated
|
|
KSR1-RAF1-MEK complex
|
|
Ku antigen complex
|
|
Ku antigen-NARG1 complex
|
|
Ku antigen-YY1-alphaMyHC promoter complex
|
|
Ku-ORC complex
|
|
Ku70/Ku86 complex
|
|
Ku70/Ku86/Werner complex
|
|
Kv4.2-DPP10 channel complex
|
|
L-periaxin-Drp2 complex
|
|
Lab-Grb2 complex, BCR stimulated
|
|
LARC complex (LCR-associated remodeling complex)
|
|
Large Drosha complex
|
|
LAT-GRB2 complex, Fyn-mLck(KA) or Syk kinase activated
|
|
LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated
|
|
LAT-PLC-gamma-1-p85-GRB2-SOS signaling complex, C305 activated
|
|
LAT2-ITGB1 complex
|
|
LATS1-HTRA2-BIRC4 complex
|
|
LCK-SLP76-PLC-gamma-1-LAT complex, pervanadate-activated
|
|
Ldb1-Lmo2-Gata-1-Tal1-E47 complex
|
|
Lef1-Tle1 complex
|
|
Lef1-Tle1-Ctnnb1 complex
|
|
LEPR homodimer complex
|
|
LIFR-LIF-gp130 complex
|
|
LIG1-9-1-1 complex
|
|
Limd1-p62-Traf6-Prkcz complex
|
|
LIN2-LIN7 complex
|
|
LIN2-LIN7-SAP97-MINT1 complex
|
|
LIN9-BMYB complex
|
|
LINC complex, quiescent cells
|
|
LINC complex, S-phase
|
|
LINC core complex
|
|
LINGO-1-Nogo-66-p75 signaling complex
|
|
Lingo1-Rtn4r-Tnfrsf19 complex
|
|
LLGL1-PAR-6B-PRKCI complex
|
|
LLGL2-PAR-6B-PRKCI complex
|
|
LMO4-BRCA1-CTIP-LDB1 complex
|
|
LMO4-CREB complex
|
|
LMO4-gp130 complex
|
|
Lnx1-Jam4 complex
|
|
LRP-1-Alpha-2-M-annexin VI complex
|
|
LSD1 complex
|
|
LSD1-CoREST complex
|
|
LSm1-7 complex
|
|
LSm2-8 complex
|
|
Lymphotoxin beta receptor complex
|
|
MAD-MAX complex
|
A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max.
|
Mad-Max-mSin3a complex
|
A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3A, a homolog of the yeast Sin3p.
|
Mad-Max-mSin3B complex
|
A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3B, a homolog of the yeast Sin3p.
|
MAD1-mSin3A-HDAC2 complex
|
|
MAD1L1 homodimer complex
|
|
MAD1L1-MAD2L1 complex
|
|
MAD2-CDC20 complex
|
|
MAF1 complex
|
|
MAF2 complex
|
|
MALT1 oligomer complex
|
|
MAML1-RBP-Jkappa-Notch1 complex
|
A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
|
MAML2-RBP-Jkappa-Notch3 complex
|
A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
|
MAML3-RBP-Jkappa-Notch3 complex
|
A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
|
MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex
|
|
Map2k5-Map3k3 complex
|
|
MAP2K5-PRKCI-SQSTM1 complex
|
|
MASH1 promoter-coactivator complex
|
|
MBD1-MCAF complex
|
|
MBD1-MCAF1-SETDB1 complex
|
|
MBD1-Suv39h1-HP1 complex
|
|
MCL1-BAK1 complex
|
|
MCM complex
|
A hexameric protein complex required for the initiation and regulation of DNA replication.
|
MCM2-MCM4-MCM6-MCM7 complex
|
|
MCM2-MCM6-MCM7 complex
|
|
MCM4-MCM6-MCM7 complex
|
|
MCM8-ORC2-CDC6 complex
|
|
MDC1-H2AFX-TP53BP1 complex
|
|
MDC1-MRE11-RAD50-NBS1 complex
|
|
MDC1-MRN-ATM-FANCD2 complex
|
|
MDC1-p53BP1-SMC1 complex
|
|
Mdm2-P53 complex
|
|
MeCP1 complex
|
|
MeCP2-SIN3A-HDAC complex
|
|
MED18-MED20-MED29 mediator subcomplex
|
|
Mediator complex
|
A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
|
Mediator complex 1
|
|
Mediator complex 2
|
|
Meiotic cohesin complex
|
A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.
|
Mekk1-Axin complex
|
|
Membrane protein complex (DERL1, SELS, VCP)
|
|
Membrane protein complex (VCP, UFD1L, SEC61B)
|
|
Membrane-associated multicomponent signaling complex, anti-CD40 stimulated (Cd40, Ikbkg, Map3k1, Traf2, Ube2n)
|
|
Menin-associated histone methyltransferase complex
|
|
Meprin A
|
|
MET-CIN85-SH3GL3-CBL complex, HGF stimulated
|
|
Metallothionein-3 complex
|
|
Metaxin complex
|
|
MGC1-DNA-PKcs-Ku complex
|
|
Mi-2/NuRD-MTA2 complex
|
|
Mi2/NuRD complex
|
|
Mi2/NuRD-BCL6-MTA3 complex
|
|
MICA-KLRK1-HCST complex
|
|
MICB-KLRK1-HCST complex
|
|
Microprocessor complex
|
A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs.
|
MIRO2-Milton complex
|
|
Mis12 centromere complex
|
|
Mitotic 14S cohesin 1 complex
|
|
Mitotic 14S cohesin 2 complex
|
|
Mitotic checkpoint complex (MCC)
|
|
MKK4-ARRB2-ASK1 complex
|
|
MKK4-ARRB2-JNK3 complex
|
|
MKP3-CK2alpha complex
|
|
MLL-HCF complex
|
|
MLL1-WDR5 complex
|
|
Mlx-Mad1 complex
|
|
MMP-2-claudin-1 complex
|
|
MMP-9-TIMP-1-LRP complex
|
|
MNK1-eIF4F complex
|
|
MOF complex
|
|
Molybdopterin synthase
|
|
MondoA-Mlx complex
|
|
mPar6c-Mlgl-aPKC complex
|
|
mPar6c-Mlgl-aPKCz complex
|
|
MPP4-MPP5-CRB1 complex
|
|
MR-UBC9-SRC1 complex
|
|
MRE11A-RAD50-NBN-TRF2 complex
|
|
MRG15-PAM14-RB complex
|
|
MRIP-MBS complex
|
|
MRIP-MBS-RHOA complex
|
|
MRIP-RHOA complex
|
|
MRIT complex
|
|
MRN complex (MRE11-RAD50-NBN complex)
|
|
MRN complex (MRE11-RAD50-NBS1 complex)
|
|
MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex)
|
|
mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN)
|
|
MSH2-MLH1-PMS2 DNA-repair initiation complex
|
|
MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex
|
|
MSH2-MSH3 complex
|
|
MSH2-MSH6 complex
|
|
MSH2-MSH6-PMS1-MLH1 complex
|
|
MSH2-MSH6-PMS2-MLH1 complex
|
|
MSH2/6-BLM-p53-RAD51 complex
|
|
MSH4-MSH5-GPS2 complex
|
|
mSin3A complex
|
|
mSin3A-HDAC1-HDAC2 complex
|
|
MSL complex
|
A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3.
|
Mss4-Itga3 complex
|
|
Mss4-Itga7 complex
|
|
MT1-MMP-claudin-1 complex
|
|
Mt3-Hsp84-Ck complex
|
|
MTA1 complex
|
|
MTA1-HDAC core complex
|
|
MTA2 complex
|
|
MTNR1A homodimer complex
|
|
MTNR1A-MTNR1B complex
|
|
MTNR1B homodimer complex
|
|
mTOR-RAPTOR complex
|
|
mTOR-RICTOR complex
|
|
mTOR-signaling complex
|
|
mTOR-signaling complex (FRAP1/mTOR, GBL, RAPTOR)
|
|
mTOR-signaling complex (mTOR/FRAP1, RAPTOR)
|
|
mTORC1 complex (mTOR/FRAP1, LST8, RAPTOR)
|
|
mTORC2 complex (mTOR/FRAP1, LST8, mAVO3/RICTOR)
|
|
mTORC2 complex (mTOR/FRAP1, LST8, mAVO3/RICTOR, SIN1)
|
|
Multicomponent signaling complex, anti-CD40 stimulated (Birc2, Birc3, Cd40, Ikbkg, Map2k4, Map2k7, Map3k1, Traf2, Ube2n)
|
|
Multicomponent signaling complex, anti-CD40 stimulated,(Birc2, Birc3, Cd40, Ikbkg, Map3k1, Traf2, Ube2n)
|
|
Multiprotein complex (monoubiquitination)
|
|
Multiprotein complex (mRNA turnover)
|
|
Multisubunit ACTR coactivator complex
|
|
Multisynthetase complex
|
A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates.
|
MURR1-NF(kappa)Bp65-IKBA complex
|
|
MUS81-CDS1 complex
|
|
Muscle-derived dystrobrevin-syntrophin complex
|
|
MutL-alpha complex
|
A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.
|
MutL-beta complex
|
A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1.
|
MutS-alpha complex
|
A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6.
|
MutS-alpha-histone H4 complex
|
|
MutS-alpha-PK-zeta complex
|
|
MutS-beta complex
|
A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3.
|
MYC-DNMT3A-ZBTB17 complex
|
|
MYC-MAX complex
|
A transcription factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max.
|
MYC-MAX-BLOC1S1 complex
|
|
Myod1 homodimer complex
|
|
Myod1-Tcf3 complex
|
|
MYOM1 homodimer complex
|
|
N-NOS-CHIP-HSP70-1 complex
|
|
N-WASp homomer
|
|
NAT complex
|
A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule.
|
NCBP-NIP1 complex
|
A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.
|
NCOA6-DNA-PK-Ku-PARP1 complex
|
|
NCOR complex
|
|
NCOR-HDAC3 complex
|
|
NCOR-SIN3-HDAC-HESX1 complex
|
|
NCOR-SIN3-HDAC1 complex
|
|
NCOR-SIN3-RPD3 complex
|
|
NCOR1 complex
|
|
NCOR2 complex
|
|
NCR3-CD247 complex
|
|
NDC80 kinetochore complex
|
|
NDPKA-AMPKalpha1 complex
|
|
Neddylin ligase (FBXO11, SKP1, CUL1, RBX1)
|
|
NEK2-NEK11 complex
|
|
NELF complex (Negative elongation factor complex)
|
|
NEMO-HIF2(alpha)-ARNT complex
|
|
Neurotrophin-3-p75 complex
|
|
NFAT-JUN-FOS DNA-protein complex
|
|
Nfatc2ip-Prmt1
|
|
NFKB1-NFKB2-REL-RELA-RELB complex
|
|
NFKB1-NFKB2-RELA-RELB complex
|
|
Nfkb1-Rela complex
|
|
Ng2-Grip1-Glur2 complex
|
|
NGF-p75 complex
|
|
NGF-TrkA complex
|
|
NgR-TROY-LINGO1 complex
|
|
Nitric oxide synthase-dystrophin complex, skeletal muscle
|
A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase.
|
NK-3-Groucho complex
|
|
NK-3-Groucho-HIPK2-SIN3A-RbpA48-HDAC1 complex
|
|
nKHC-KLC1-KLC2 kinesin complex
|
|
NMI homodimer complex
|
|
NMI-POLR1B-RRN3 complex
|
|
Nmi-Rpa2-Rrn3 complex
|
|
Nmi-Rrn3 complex
|
|
nNos-Capon-Dexras1 complex
|
|
NOD1 homodimer complex
|
|
Nogo-potassium channel complex
|
|
Nop56p-associated pre-rRNA complex
|
|
NOS3-CAV1-NOSTRIN complex
|
|
Notch1(N-TM)-Notch1(N-EC) heterodimer complex
|
|
Notch1-fraction 30 complex
|
|
Notch1-p56lck-PI3K complex
|
|
Notch2(N-TM)-Notch2(N-EC)-Delta complex
|
|
NPC subcomplex (NUP98, NUP107, NUP133, NUP160)
|
|
NR3C2-UBC9-SRC-1 complex
|
|
NRD complex (Nucleosome remodeling and deacetylation complex)
|
|
NRG1-IKZF4 complex
|
|
Nrp1-PlexinD1 complex
|
|
NRP1-VEGF(165/121) complex
|
|
NRP1-VEGFC complex, heparin dependent
|
|
NRP1-VEGFD complex, heparin dependent
|
|
NRP1-VEGFR2-VEGF(165) complex
|
|
NRP2-VEGFC complex
|
|
NRP2-VEGFD complex, heparin dependent
|
|
NRP2-VEGFR3 complex
|
|
NTF4 homodimer complex
|
|
NuA4/Tip60 HAT complex
|
|
NuA4/Tip60-HAT complex A
|
|
NuA4/Tip60-HAT complex B
|
|
Nucleic and chromatin Fanconi complex
|
|
Nucleolar remodeling complex (NoRC complex)
|
|
NuMA-LGN-G-alpha-i-1 complex
|
|
NUMAC complex (nucleosomal methylation activator complex)
|
|
NUMB-TP53-MDM2 complex
|
|
Nup 107-160 subcomplex
|
|
NuRD.1 complex
|
|
OAP-1-OSP/claudin-11-ITGB1 complex
|
|
Ocrl-Cdc42 complex
|
|
OCT1-OBF1-DNA complex
|
|
OCT1-OBF1-DNA-TLE1 complex
|
|
OCT1-SOX2 DNA-protein complex
|
|
OCT2-TLE4 complex
|
|
OCT4-SOX2 DNA-protein complex
|
|
OGT-TRAK1-TRAK2 complex
|
|
Olfr992-Reep1 complex
|
|
Olfr992-Rtp1 complex
|
|
Oligosaccharyltransferase complex (Stt3A variant)
|
|
Oligosaccharyltransferase complex (Stt3B variant)
|
|
ORC 1-5 complex (origin recognition 1-5 complex)
|
|
ORC 2-4 complex (origin recognition 2-4 complex)
|
|
ORC 2-5 complex (origin recognition 2-5 complex)
|
|
ORC complex (origin recognition complex)
|
|
ORC5-ORC1 complex
|
|
P-TEFb-7SKRNA-HEXIM1 complex
|
|
P-TEFb-BRD4-TRAP220 complex
|
|
P-TEFb-SKP2 complex
|
|
P-TEFb.1 complex
|
|
P-TEFb.2 complex
|
|
P-TEFb.4 complex
|
|
p130Cas-ER-alpha-cSrc-kinase- PI3-kinase p85-subunit complex
|
|
p14-Mp1-Erk1/2 complex
|
|
p14-Mp1-ERK2 complex
|
|
p14-Mp1-MEK1 complex
|
|
p16-cyclin D2-CDK4 complex
|
|
p18-Cdk4 complex
|
|
p18-Cdk6 complex
|
|
p19-Cdk4 complex
|
|
p19-Cdk4-cyclinD2 complex
|
|
p19-Cdk6 complex
|
|
p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated
|
A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation.
|
p23 protein complex
|
|
p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex
|
|
p27-cyclinE-CDK2 complex
|
|
P2X7 receptor signalling complex
|
|
p300-CBP-p270 complex
|
|
p300-CBP-p270-SWI/SNF complex
|
|
p300-MDM2-p53 protein complex
|
|
p300/CBP-PCAF-MyoD complex
|
|
p32-CBF-DNA complex
|
|
p33ING1b-HDAC1 complex
|
|
p33ING1b-p300 complex
|
|
p33ING1b-PCNA complex
|
|
p34(SEI-1)-CDK4-CyclinD2 complex
|
|
p400-associated complex
|
|
p50-p65 NF(kappa)B complex
|
|
p50-p65 NF(kappa)B-SRC1 complex
|
|
p53 homotetramer complex
|
|
P53-BARD1-Ku70 complex
|
|
p53-Bcl-xL complex, DNA-damage induced
|
|
p53-SP1 complex
|
|
p54(nrb)-PSF-matrin3 complex
|
|
p56(LCK)-CAML complex
|
|
p97-Ufd1-Npl4-IP3 receptor complex
|
|
p97/VCP homohexamer complex
|
|
p97/VCP-VIMP-DERL1 complex
|
|
p97/VCP-VIMP-DERL1-DERL2-HRD1-SEL1L complex
|
|
p97/VCP-VIMP-DERL2 complex
|
|
PA28 complex
|
|
PA28-20S proteasome
|
|
PA28gamma complex
|
|
PA28gamma-20S proteasome
|
|
PA700 complex
|
|
PA700-20S-PA28 complex
|
|
PABPC1-HSPA8-HNRPD-EIF4G1 complex
|
|
PAC1-PAC2 complex
|
|
PAC3-PAC4 complex
|
|
Paf complex
|
|
Pallidin-Mu complex
|
|
Par-3-p75NTR complex
|
|
PAR-3-PAR-6B-PRKCI complex
|
|
PAR-3-VE-cadherin complex, endothelial
|
|
PAR-3-VE-cadherin-beta-catenin complex
|
|
PAR-6-PAR-3-VE-cadherin complex, endothelial
|
|
PAR-6-VE-cadherin complex, endothelial
|
|
PAR3-PAR6-PALS1 complex
|
|
PAR4-BACE1 complex
|
|
PAR6-CDC42 complex
|
|
PARVB-ARHGEF6 complex
|
|
Parvulin-associated pre-rRNP complex
|
|
Pax3-Lef1-Tle4 complex
|
|
PAX6-SOX2 DNA-protein complex
|
|
Pax7-HMT complex
|
|
PAX9-MSX1 complex
|
|
PBAF complex (Polybromo- and BAF containing complex)
|
|
PC2 complex
|
|
PCAF complex
|
A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs.
|
Pcdha7-Pcdhga1 complex
|
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane.
|
Pcdha7-Pcdhga3 complex
|
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane.
|
Pcdha7-Pcdhgb2 complex
|
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane.
|
Pcdha7-Pcdhgb4 complex
|
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane.
|
Pcdhga1-Pcdha4 complex
|
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane.
|
Pcdhga1-Pcdhga3 complex
|
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane.
|
Pcdhga1-Pcdhgb2 complex
|
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane.
|
Pcdhga1-Pcdhgb4 complex
|
A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane.
|
PCI-PSA-SCG2 complex
|
|
PCNA homotrimer complex
|
|
PCNA-CHL12-RFC2-5 complex
|
|
PCNA-DNA ligase complex
|
|
PCNA-DNA polymerase delta complex
|
|
PCNA-KU antigen complex
|
|
PCNA-MLH1-PMS1 complex
|
|
PCNA-MSH2-MSH6 complex
|
|
PCNA-MutS-alpha-DNA initial complex
|
|
PCNA-MutS-alpha-MutL-alpha-DNA complex
|
|
PCNA-p21 complex
|
A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication.
|
PCNA-PAF complex
|
|
PCNA-RFC2-5 complex
|
|
PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated
|
A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA), phospholipase C-gamma-1 (PLC-gamma-1), phosphatidylinositol 3-kinase (PI3K) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.
|
PDGFRA-SHP-2 complex, PDGF stimulated
|
A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.
|
PDZK1-NaPiIIa-MAP17 complex
|
|
Pericentrin-GCP complex
|
|
PEX14 homodimer complex
|
|
Pex26-Pex6-Pex1 complex
|
|
PGAM5-KEAP1-NRF2 complex
|
|
PGC-1-SRp40-SRp55-SRp75 complex
|
|
PGRMC1-SCAP complex
|
|
PHAX-CBC complex (cap binding complex)
|
|
Phosphatidylinositol 3-kinase (PIK3CA, PIK3R1)
|
|
Phosphatidylinositol 3-kinase complex (PIK3C3, PIK3R4)
|
|
PIAS3-SMAD3-P300 complex
|
|
PICK1-GRIP1-GLUR2 complex
|
|
PID complex
|
|
PIDDsome complex
|
|
Pik3r5-Pik3cg complex
|
|
PIN1-AUF1 complex
|
|
PINK1-MIRO2-Milton complex
|
|
PIP complex
|
|
PKC-alpha-PLD1-PLC-gamma-2 signaling complex, lacritin stimulated
|
|
PKD2-FPC complex
|
|
Pkd2-Fpc-Kif3b complex
|
|
PKD2-PACS1 complex
|
|
Pkhd1-Pkd2 complex
|
|
PLC-gamma-1-Lab-Blnk complex, BCR stimulated
|
|
PLC-gamma-1-LAT-c-CBL complex, OKT3 stimulated
|
|
PLC-gamma-1-SLP-76-SOS1-LAT complex
|
|
PLC-gamma-2-Lab-Blnk complex, BCR stimulated
|
|
PLC-gamma-2-LAT complex
|
|
PLC-gamma-2-Lyn-FcR-gamma complex
|
|
PLC-gamma-2-SLP-76 complex
|
|
PLC-gamma-2-SLP-76-Lyn-Grb2 complex
|
|
PLC-gamma-2-Syk-LAT-FcR-gamma complex
|
|
PLCB1-PARD3-PARD6A complex
|
|
PLCB3-PARD3-PARD6A complex
|
|
PLEKHM2-KIF5B complex
|
|
PlexinA1-NRP1 complex
|
|
PlexinA1-NRP1-SEMA3A complex
|
|
PlexinA1-PlexinB1 complex
|
|
PLXNA1-RANBPM complex
|
|
PLXNA2-RANBPM complex
|
|
PLXNA3-RANBPM complex
|
|
PLXNA4-RANBPM complex
|
|
PML-SMAD2/3-SARA complex
|
|
PNUTS-PP1 complex
|
|
POLR1B-RRN3 complex
|
|
POLR2A-CCNT1-CDK9-NCL-LEM6-CPSF2 complex
|
|
Polyadenylation complex (CSTF1, CSTF2, CSTF3, SYMPK CPSF1, CPSF2, CPSF3)
|
|
Polycomb repressive complex
|
|
Polycomb repressive complex 1 (PRC1, hPRC-H)
|
|
Polycomb repressive complex 2 (PRC 2)
|
|
Polycomb repressive complex 2 (PRC2)
|
|
Polycomb repressive complex 3 (PRC3)
|
|
Polycomb repressive complex 4 (PRC4)
|
|
Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1)
|
|
Polycystin-1-E-cadherin-beta-catenin complex
|
|
Polycystin-1-E-cadherin-beta-catenin-Flotillin-2 complex
|
|
POSH-AKT2 complex
|
|
POSH-MLK3 complex
|
|
Postsplicing complex
|
|
PPD complex
|
|
PPP2CA-PPP2R1A complex
|
|
PPP2CA-PPP2R1A-PPP2R3A complex
|
|
PPP2R1A-PPP2R1B-PPP2CA-PPME1-EIF4A1 complex
|
|
PPP3CA-PPP3CA-RCAN1 complex
|
|
PPP4C-PPP4R2-Gemin3-Gemin4 complex
|
|
pRB-E2F-1 complex
|
|
pRb2/p130-multimolecular complex (DNMT1, E2F4, SuV39H1, HDAC1, RBL2)
|
|
pRb2/p130-multimolecular complex (DNMT1, E2F5, SuV39H1, HDAC1, RBL2)
|
|
pRb2/p130-multimolecular complex (RB2, E2F4, HDAC1, SUV39H1, P300)
|
|
pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300)
|
|
Pre-initiation complex (PIC)
|
|
Prefoldin
|
|
Prefoldin complex
|
A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics.
|
PRKAC-AKAP5-ADRB1 complex
|
|
PRL receptor (PRLR) dimer complex
|
|
PRMT1 complex
|
|
PRMT2 homo-oligomer complex
|
|
PRMT2 homodimer complex
|
|
PRMT5 complex
|
|
PRNP homo-oligomer complex
|
|
Prnp homodimer complex
|
|
PRNP-ApolopoproteinE3 complex
|
|
Profilin 1 complex
|
|
Profilin 2 complex
|
|
Prolactin (PRL) - PRL receptor (PRLR) complex
|
|
Prolyl 4-hydroxylase (alpha(I)-type)
|
|
Prolyl 4-hydroxylase (alpha(III)-type)
|
|
Protein kinase A II alpha homodimer complex
|
|
Protein phosphatase 4 complex
|
The complex formed by the catalytic subunit of protein phosphatase 4 plus a regulatory subunit.
|
Protein-sorting complex (Stam2, Hgs, Eps15)
|
|
Prune-Gelsolin complex
|
|
Prune-GSK3beta complex
|
|
Prune/Nm23-H1 complex
|
|
PS1-E-cadherin-catenin complex, brain
|
|
Psd3-Actn1 complex
|
|
PSD95-FYN-NR2A complex
|
|
PSF-p54(nrb) complex
|
|
PTF1 complex (Ptf1a, Tcf12, Rbpj)
|
|
PTF1-bHLH complex
|
|
PTGS2 homodimer complex
|
|
PTIP-DNA damage response complex
|
|
PTIP-HMT complex
|
|
PTPRA homodimer complex
|
|
PU.1-associated protein complex
|
|
PU.1-SIN3A-HDAC complex
|
|
PU.1-Sin3A-Hdac-MeCP2 complex
|
|
PU.1-TBP complex
|
|
PUMA-Bcl-xL complex, DNA-damage induced
|
|
PXN-ITGB5-PTK2 complex
|
|
PYR complex
|
|
Quaternary complex (Dvl, Gsk3b, Frat1, Axin1)
|
|
R/M complex (RAD50-MRE11 complex)
|
|
Rab11Fip2-Ap2a complex
|
|
Rab27a-melanophilin-myosin-Va complex
|
|
Rab27A-Melanophilin-MyosinVa complex
|
|
Rab27a-Mlph-Myo5a complex
|
|
Rab3a-Rims2-Rapgef4 complex
|
|
Rab5 GDP/GTP exchange factor complex
|
|
RAB5-EEA1 complex
|
|
RAB9-TIP47-MPRI complex
|
|
RAD17-RFC complex
|
|
RAD17-RFC-9-1-1 checkpoint supercomplex
|
|
RAD50-BRCA1 complex
|
|
RAD50-MRE11-NBN-p200-p350 complex
|
|
RAD51-DMC1 complex
|
|
RAD51B-RAD51C complex
|
A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof.
|
RAD51B-RAD51C-RAD51D-XRCC2-XRCC3 complex
|
|
RAD51C-XRCC3 complex
|
A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof.
|
RAD51L3-XRCC2 complex
|
|
RAD52-ERCC4-ERCC1 complex
|
A nucleotide-excision repair complex formed by the association of the heterodimeric endonuclease XPF/ERCC4-ERCC1 (Rad1p and Rad10p in S. cerevisiae) with the RAD52 protein.
|
RAD9-RAD1-HUS1-APE1 complex
|
|
RAD9-RAD1-HUS1-POLB complex
|
|
RAF1-BRAF complex, RAS stimulated
|
|
RAF1-CNK1 complex, RAS stimulated
|
|
RAF1-MAP2K1-YWHAE complex
|
|
Raf1-PP2A core enzyme complex (Ppp2r1a, Ppp2ca), untreated
|
|
Raf1-PP2A holoenzyme complex (Ppp2r1a, Ppp2r2b, Ppp2ca), PDGF stimulated
|
|
RAF1-PPP2-PIN1 complex
|
|
RAF1-RAS complex, EGF induced
|
|
Rag1-Rag2 protein-DNA complex
|
|
RAG1-RAG2 tetramer complex
|
|
Rag1-Rag2-Ku70-Ku80 protein-DNA complex
|
|
RalBP1-CCNB1-AP2A-NUMB-EPN1 complex
|
|
RalBP1-CDC2-CCNB1 complex
|
|
RANBMP-CD39 complex
|
|
RANBP1-RAN-KPNB1 complex
|
|
RANBPM-Muskelin-TWA1-HSMpp8 complex
|
|
RANBPM-SMP1 complex
|
|
Rap1 complex
|
|
RAPTOR-mTOR complex
|
|
RasGAP-AURKA/AURKB-survivin complex
|
|
Rb-HDAC1 complex
|
|
Rb-NeuroD1-Ngfi-B complex
|
|
Rb-tal-1-E2A-Lmo2-Ldb1 complex
|
|
RB1(hypophosphorylated)-E2F4 complex
|
|
RB1-HDAC1-BRG1 complex
|
|
Rb1-Runx2 complex
|
|
RB1-TFAP2A complex
|
|
RBP-Jkappa-Notch1 complex
|
|
RBP-Jkappa-RING1-KyoT2 complex
|
|
RBP-Jkappa-SHARP complex
|
|
RBPJ-NotchIC-Mastermind complex
|
|
RC complex (Replication competent complex)
|
|
RC complex during G2/M-phase of cell cycle
|
|
RC complex during S-phase of cell cycle
|
|
RCP-Rab11 complex
|
|
REL-MAP3K8-RELA-TNIP2-PAPOLA complex
|
|
Remodeling and spacing factor (RSF) complex
|
|
Replication-coupled CAF-1-MBD1-ETDB1 complex
|
|
Respiratory chain complex I (beta subunit) mitochondrial
|
|
Respiratory chain complex I (early intermediate NDUFAF1 assembly), mitochondrial
|
|
Respiratory chain complex I (gamma subunit) mitochondrial
|
|
Respiratory chain complex I (holoenzyme), mitochondrial
|
|
Respiratory chain complex I (incomplete intermediate ND1, ND2, ND3, CIA30 assembly), mitochondrial
|
|
Respiratory chain complex I (incomplete intermediate), mitochondrial
|
|
Respiratory chain complex I (incomplete NDUFAF1 assembly), mitochondrial
|
|
Respiratory chain complex I (intermediate I/200kD and III/250kD), mitochondrial
|
|
Respiratory chain complex I (intermediate II/230kD), mitochondrial
|
|
Respiratory chain complex I (intermediate IV/310kD), mitochondrial
|
|
Respiratory chain complex I (intermediate V/380kD and VI/480kD), mitochondrial
|
|
Respiratory chain complex I (intermediate VII/650kD), mitochondrial
|
|
Respiratory chain complex I (lambda subunit) mitochondrial
|
|
Respiratory chain complex I, mitochondrial
|
|
REST-CoREST-mSIN3A complex
|
|
RET-Rai complex
|
|
Retn homohexamer complex
|
|
Retn homotrimer complex
|
|
Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A)
|
|
Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B)
|
|
Retrotranslocation complex
|
|
RFC complex
|
A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase.
|
RFC complex (activator A 1 complex)
|
|
RFC core complex
|
A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37.
|
RFC2-5 subcomplex
|
|
RFC2-RIalpha complex
|
|
RGS6-DNMT1-DMAP1 complex
|
A protein complex formed by the association of RGS6, a negative regulator of heterotrimeric G protein signaling, with the DMAP1-Dnmt1 transcriptional repressor complex; in the complex, RGS6 inhibits the transcriptional repressor activity of DMAP1.
|
RHOA-IP3R-TRPC1 complex
|
|
RIAM-profilin complex
|
|
RIAM-Rap1-GTP complex
|
|
RIAM-VASP complex
|
|
Ribosome, cytoplasmic
|
|
RICH1-PAR3-aPKC polarity complex
|
|
RICH1/AMOT polarity complex, Flag-Amot precipitated
|
|
RICH1/AMOT polarity complex, Flag-Rich1 precipitated
|
|
RICTOR-mTOR complex
|
|
RIN1-STAM2-EGFR complex, EGF stimulated
|
|
RIN1-STAM2-HRS complex
|
|
Ripk2-Nod2 complex
|
|
RNA endonuclease (SEN2deltaEx8, SEN54, CLP1)
|
|
RNA pol II containing coactivator complex Tat-SF
|
|
RNA polymerase II (RNAPII)
|
|
RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying
|
|
RNA polymerase II complex (RPB1, RAP74, CDK8, CYCC, SRB7, BAF190, BAF47), chromatin structure modifying
|
|
RNA polymerase II complex, chromatin structure modifying
|
|
RNA polymerase II complex, incomplete (CBP, RPBI, PCAF, BAF47), chromatin structure modifying
|
|
RNA polymerase II complex, incomplete (CDK8 complex), chromatin structure modifying
|
|
RNA polymerase II core complex
|
|
RNA polymerase II holoenzyme complex
|
|
RNA-induced silencing complex, RISC
|
|
Rnase/Mrp complex
|
A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication.
|
RNF11-SMURF2-STAMBP complex
|
|
RNF20-RNF40-UbE2E1 complex
|
|
RPA complex
|
|
RPA-MSH4-BLM complex
|
|
Rpa2-Rrn3 complex
|
|
RPAP1-RPB2-RPB3 complex
|
|
RSmad complex
|
|
RUNX1-CBF-beta-DNA complex
|
|
Ryk-Dvl1 complex
|
|
Ryk-Wnt3a complex
|
|
Ryk-Wny1 complex
|
|
Ryk-Wny1-Fzd8 complex
|
|
S-phase-specific E2F-p107 complex
|
|
S100A10-annexin 2 complex
|
|
Sam68-p120GAP complex
|
|
Sam68-p85 P13K-IRS-1-IR signaling complex
|
|
SAP complex (Sin3-associated protein complex)
|
|
Sarcoglycan-sarcospan complex SG-SPN
|
|
Sarcoglycan-sarcospan-complex SG-SPN
|
|
Sarcoglycan-sarcospan-dystroglycan complex
|
|
Sarcoglycan-sarcospan-syntrophin-dystrobrevin complex
|
|
SCAMP1-SCAMP2 complex
|
|
SCAMP1-SCAMP2-SCAMP3 complex
|
|
SCF subcomplex (WEE1, SKP2, BTRC)
|
|
SCRIB-APC complex
|
A protein complex that contains the Scribble protein (a cell polarity determinant) and the tumor suppressor protein adenomatous polyposis coli (APC); may be involved in the control of cell proliferation.
|
Scrib-APC-beta-catenin complex
|
A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation.
|
Scrib-beta-PIX-GIT1 complex
|
|
SCRIB-LGL2 complex
|
|
SCRIB-VANGL2 complex
|
|
Sdc2-Ephb2 complex
|
|
Sec6/8 exocyst complex
|
|
Sec61alpha-CollagenIV-Hsp47 complex
|
|
Securin-separase complex
|
|
SEMA4A-PlexinD1 complex
|
|
SEMA6D-PlexinA1-NRP1 complex
|
|
Septin complex
|
A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric.
|
Serine-palmitoyltransferase (SPT) complex
|
|
SERPINA1-CTSG complex
|
|
SERPINA1-ELA2 complex
|
|
SERPINA3-CTSG complex
|
|
Set1A complex
|
|
Set1B complex
|
|
SETDB1-containing HMTase complex
|
|
SF3A1-SF3A2-SF3A3 complex
|
|
SF3b complex
|
|
SH3KBP1-CBLB-EGFR complex
|
|
Sh3kbp1-Cblb-Pdgfrb complex
|
|
SH3P2/OSTF1-CBL-SRC complex
|
|
SHARP-CtBP complex
|
|
SHARP-CtBP1-CtIP complex
|
|
SHARP-CtBP1-CtIP-RBP-Jkappa corepressor complex
|
|
SHARP-CtIP-RBP-Jkappa complex
|
|
SHC-GRB2 complex
|
|
Shc-Grb2-mSos1 complex, EGF stimulated
|
A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
|
Shc-Ship-Grb2 complex, IL-3 stimulated
|
|
SHC3-GAB1 complex
|
|
Ship-Shc complex, IL-3 stimulated
|
|
SHP-NR5A2 complex
|
|
Shp2-Sos complex, FGF stimulated
|
|
SIN3 complex
|
A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins.
|
SIN3-HDAC-SAP30-ARID4 complex
|
|
Sin3-Hdac1-Sds3 complex
|
|
SIN3-ING1b complex I
|
|
SIN3-ING1b complex II
|
|
SIN3-SAP25 complex
|
|
Sirpa-Pik3cg complex
|
|
SIRT1 homotrimer complex
|
|
SIRT1-HNF4-alpha-PGC-1-alpha complex, in response to fasting
|
|
Skeletal muscle sarcoglycan complex SGC, alpha-beta-epsilon-gamma
|
|
Skeletal muscle sarcoglycan complex SGC, alpha-beta-gamma-delta
|
|
Skeletal muscle sarcoglycan complex SGC, beta-gamma-delta-zeta
|
|
Skeletal muscle sarcoglycan complex SGC, epsilon-beta-gamma-delta
|
|
SKI complex
|
A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p.
|
SKI-NCOR1-SIN3A-HDAC1 complex
|
|
SKI-SMAD2 hexameric complex
|
|
SKI-SMAD2-SMAD4 pentameric complex
|
|
SKI-SMAD3 hexameric complex
|
|
SKI-SMAD3-SMAD4 pentameric complex
|
|
Slam-SAP complex
|
|
Slam-SAP-FynT complex
|
|
Slam-SAP-SHIP complex
|
|
SLC1A2 homotrimer complex
|
|
SLP-76-Cbl-Grb2-Shc complex, Fc receptor gamma-R1 stimulated
|
|
SLP-76-PLC-gamma-1-ITK complex, alpha-TCR stimulated
|
|
SLP-76-PLC-gamma-1-VAV complex, alpha-TCR stimulated
|
|
Slp5-Rab27A complex
|
|
SMAD1-CBP complex
|
|
Smad1-Notch1-p300-Pcaf complex
|
|
SMAD1-P300 complex
|
|
SMAD2-FAST1 complex
|
|
SMAD2-SKI complex
|
|
SMAD2-SKI-NCOR complex
|
|
Smad2-Smad4 complex
|
|
SMAD2-SMAD4-FAST1 complex
|
|
SMAD3-cSKI-SIN3A-HDAC1 complex
|
|
SMAD3-E2F4/5-p107-DP1 complex
|
|
SMAD3-HEF1-APC10-CDH1 complex
|
|
SMAD3-SKI complex
|
|
SMAD3-SKI-NCOR complex
|
|
Smad3-Smad4 complex
|
A heteromeric SMAD protein complex that contains SMAD3 and SMAD4.
|
SMAD3-SMAD4-cJUN complex
|
|
SMAD3-SMAD4-cJun-cFos complex
|
|
SMAD3-SMAD4-cSKI, TGF(beta)-dependent
|
|
SMAD3-SMAD4-CTCF protein-DNA complex
|
|
SMAD3-SMAD4-FOXO1 complex
|
|
SMAD3-SMAD4-FOXO3 complex
|
|
SMAD3-SMAD4-FOXO3-FOXG1 complex
|
|
SMAD3-SMAD4-FOXO4 complex
|
|
SMAD3-SMAD4-SP1 complex
|
|
SMAD3-VDR complex
|
|
SMAD3/4-E2F4/5-p107-DP1 complex
|
|
SMAD4-SKI complex
|
|
SMAD4-SKI-NCOR complex
|
|
SMAD4-SMAD2-SMAD3 complex
|
|
SMAD4-SNO-SKI complex
|
|
SMAD6-HOXA9 complex
|
|
SMAD6-HOXC8 complex
|
|
SMAD7-SMURF2 complex
|
|
SMARCA2/BRM-BAF57-MECP2 complex
|
|
Smarcb1/Ini1-Smarca2-Mecp2 complex
|
|
SMC1-SMC3 complex
|
The core heterodimer of a cohesin complex; a structure required for sister chromatid cohesion in eukaryotes.
|
Smcb-Smcd-PW29 complex
|
|
SMCC complex
|
|
SMG-1-Upf1-eRF1-eRF3 complex (SURF)
|
|
SMN complex
|
A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus.
|
SMN complex (GEMIN2,5, SMN)
|
|
SMN complex (GEMIN5,2,3,4, SMN)
|
|
SMN complex (GEMIN5,4,3), SMN-independent intermediate
|
|
SMN complex (GEMIN6,7, UNRIP), SMN-independent intermediate
|
|
SMN complex, U7 snRNA specific
|
|
SMN containing complex
|
|
SMN-PolII-RHA complex
|
|
SMN1-SIP1-SNRP complex
|
|
Smooth muscle sarcoglycan complex SGC, beta-delta-zeta
|
|
SMRT complex
|
|
SMRT core complex
|
|
Smrt-Sin3A-Hdac7 complex
|
|
SMRT-SKIP-CBF1 complex
|
|
Smurf1-Par6 complex
|
|
SMURF2-SMAD3-SnoN complex, TGF(beta)-dependent
|
|
SNAPc (small nuclear RNA-activating protein) complex
|
|
SNARE complex (HGS, SNAP25, STX13)
|
|
SNARE complex (RINT1, ZW10, p31)
|
|
SNARE complex (SNAP23, STX1A)
|
|
SNARE complex (SNAP25, VAMP3, VAMP2, NAPB, STX13)
|
|
SNARE complex (STX11, VAMP2, SNAP23)
|
|
SNARE complex (STX1A, SNAP29)
|
|
SNARE complex (STX2, SNAP23)
|
|
SNARE complex (STX4, SNAP23)
|
|
SNARE complex (STX4, SNAP23, VAMP1)
|
|
SNARE complex (STX4, SNAP23, VAMP2)
|
|
SNARE complex (Stx4, Stx6, Stx7, Vamp3, Vamp7, Vamp8, Vti1b)
|
|
SNARE complex (STX4, VAMP1, VAMP7)
|
|
SNARE complex (Stx4, Vamp2, Snap23)
|
|
SNARE complex (Stx4, Vamp8, Snap23)
|
|
SNARE complex (STX4, VAMP8, VAMP3, SNAP23)
|
|
SNARE complex (STX6, SNAP23)
|
|
SNARE complex (VAMP2, SNAP25, STX13)
|
|
SNARE complex (VAMP2, SNAP25, STX1a, CPLX1)
|
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof).
|
SNARE complex (VAMP2, SNAP25, STX1a, CPLX1, CPLX3)
|
|
SNARE complex (VAMP2, SNAP25, STX1a, CPLX2)
|
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof).
|
SNARE complex (VAMP2, SNAP25, STX1a, CPLX3, CPLX4)
|
|
SNARE complex (VAMP2, SNAP25, STX1a, STX3, CPLX1, CPLX3, CPLX4)
|
|
SNARE complex (VAMP3, STX6, VTI1A)
|
|
SNARE complex (VAMP3, VAMP4, STX16)
|
A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof).
|
SNARE complex (VAMP3, VAMP4, VAMP8, STX6)
|
|
SNARE complex (VAMP4, STX6, STX16, VTI1a, VTI1b)
|
|
SNARE complex (Vti1b, Stx6, Stx7)
|
|
SNARE complex (Vti1b, Stx7, Stx8, Vamp8)
|
|
SNF2h-cohesin-NuRD complex
|
|
SNF2h-HDAC12 complex
|
|
SNF2L-RSF1 complex
|
|
snRNP-free U1A (SF-A) complex
|
|
Snurportin-CRM1-RanGTP complex
|
|
SNW1 complex
|
|
SNX complex (SNX1, SNX6)
|
|
SNX complex (SNX1,1a,2,4, PDGF receptor)
|
|
SNX complex (SNX1a, SNX2, SNX4)
|
|
SNX complex (SNX1a, SNX2, SNX4, EGFR)
|
|
SNX complex (SNX1a, SNX2, SNX4, INSR)
|
|
SNX complex (SNX1a, SNX2, SNX4, LEPR)
|
|
SNX complex (SNX1a, SNX2, SNX4, TFRC)
|
|
SNX complex (SNX2), oligomeric
|
|
Sororin-cohesin complex
|
|
SORT1-NGFR complex
|
|
SORT1-NGFR-NGFB complex
|
|
Sos1-Abi1-Eps8 complex
|
|
SP1-E2F1 complex
|
|
SP1-MCAF2 complex
|
|
Spen-Hivep1 complex
|
|
Spliceosome
|
Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron.
|
Splicing-associated factors complex
|
|
SRA-SRC-1 ribonucleoprotein complex
|
|
SRC-1 complex
|
|
SRC-3 complex
|
|
Src-dynamin-synapsin complex
|
|
SRC-PRKCD-CDCP1 complex
|
|
Src1-Ep300-Crebbp complex
|
|
SRCAP-associated chromatin remodeling complex
|
|
Srf-myogenin-E12 complex
|
A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes.
|
SRI homodimer complex
|
|
SRm160-SRm300 complex
|
|
SRm160/300 complex
|
|
STAGA complex (SPT3-TAF9-GCN5 acetyltransferase complex)
|
|
STAGA core complex (SPT3-TAF9-GCN5 acetyltransferase complex)
|
|
Stat1-alpha-dimer-CBP DNA-protein complex
|
|
STAT3 homodimer copmplex
|
|
Stat3-Crebbp complex
|
|
STAT3-NLK-MAP3K7 complex
|
|
STAT5A homodimer complex
|
|
Stat5a-Jak2 complex
|
|
STAT5B homodimer complex
|
|
STAT6-p100-RHA complex
|
|
SUA1-UBA2 complex
|
|
Succinate dehydrogenase complex II (EC 1.3.5.1), mitochondrial
|
|
Succinyl-CoA synthetase, ADP-forming
|
A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP.
|
Succinyl-CoA synthetase, GDP-forming
|
A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP.
|
Sulphiredoxin-peroxiredoxin complex
|
|
SUMO1-SUA1-UBA2 complex
|
|
Sur2 subcomplex of mediator
|
|
Survivin homodimer complex
|
|
SVIP-p97/VCP-DERL1 complex
|
|
SWAP complex
|
|
SWI-SNF chromatin remodeling-related-BRCA1 complex
|
|
SWI/SNF chromatin-remodeling complex
|
|
SWI/SNF chromatin-remodeling complex (Mecp2, Smarc)
|
|
SWI/SNF-related complex
|
|
Sycp1-Syce1-Syce2 complex
|
|
Tacc1-chTOG-AuroraA complex
|
|
TAF4-TAF12 subcomplex of TFIID complex
|
|
TAJ-NgR1-LINGO-1 signaling complex
|
|
TALL1 homo-oligomer complex
|
|
TANK-TRAF2-TRAF3 complex
|
|
Tankyrin 1-tankyrin 2-TRF1 complex
|
|
tBID-BAK1 complex
|
|
TBP-TAF complex
|
|
TBPIP/HOP2-MND1 complex
|
|
TCF4-CTNNB1 complex
|
|
TCF4-CTNNB1-CREBBP complex
|
|
TCF4-CTNNB1-EP300 complex
|
|
TCF4-CTNNB1-SUMO1-EP300-HADAC6 complex
|
|
TCL1(homotrimer) complex
|
|
TCL1(trimer)-AKT1 complex
|
|
TCL1(trimer)-AKT2 complex
|
|
TDT-TDIF2-core-histone complex
|
|
TEAD1-YAP DNA-protein complex
|
|
TEAD2-multiprotein complex
|
A protein complex that consists of the DNA binding protein TEAD-2 bound to 12 other polypeptides including the transcriptional coactivator YAP, the multi-PDZ domain protein MPDZ (also called MUPP1), a 14-3-3 domain protein, and others.
|
TEAD2-YAP DNA-protein complex
|
|
TEAD3-YAP DNA-protein complex
|
|
TEAD4-YAP DNA-protein complex
|
|
Telosome complex
|
|
TERF1 homodimer complex
|
|
TERF2-RAP1 complex
|
|
Ternary COG subcomplex
|
|
Ternary complex (Abl1, Dok1, Nck1)
|
|
Ternary complex (GATA4, SRF, MYOCD)
|
|
Ternary complex (LRRC7, CAMK2a, ACTN4)
|
|
Ternary complex (TRAF2, FADD, TRADD)
|
|
Tetrameric COG subcomplex
|
|
TF-FVIIa-FXa-TFPI complex
|
|
TFIIA complex
|
|
TFIIA-TRF2 complex
|
|
TFIID complex
|
|
TFIID complex, B-cell specific
|
A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4.
|
TFIID subcomplex
|
|
TFIID subcomplex, testis-specific
|
|
TFIID-beta complex
|
|
TFIIE complex
|
|
TFIIF complex (transcription factor IIF)
|
|
TFIIH transcription factor complex
|
|
TFIIH transcription factor complex (ERCC2, ERCC3, GTF2H1, CDK7, CCNH, GTF2H2)
|
|
TFIIH transcription factor core complex
|
|
TFIIIC containing complex
|
|
TFIIIC containing complex TFIIIC2
|
|
TFIIIC containing-TOP1-SUB1 complex
|
|
TFTC complex (TATA-binding protein-free TAF-II-containing complex)
|
|
TFTC-type histone acetyl transferase complex
|
|
TGF-beta receptor
|
|
TGF-beta receptor I-Axin-SMAD3 complex
|
|
TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex
|
A protein complex that is formed by the association of a ligand-bound TGF-beta type II receptor dimer with a TGF-beta type I receptor dimer.
|
TGF-beta receptor II-TGF-beta receptor I-TGF-beta3 complex
|
|
TGF-beta receptor II-TGF-beta1 complex
|
A protein complex that consists of a dimeric transforming growth factor beta (TGF-beta) type II receptor bound to a TGF-beta1 dimer.
|
TGF-beta receptor II-TGF-beta3 complex
|
|
TGF-beta receptor-SMAD3 complex
|
|
TGF-beta-receptor II-TGF-beta1 complex
|
A protein complex that consists of a dimeric transforming growth factor beta (TGF-beta) type II receptor bound to a TGF-beta1 dimer.
|
TGF-beta-receptor type II homodimer complex
|
|
TGF-beta-receptor-PAR6 complex
|
|
TGM2-HD complex
|
|
TGM2-HD-CALM1 complex
|
|
THO complex
|
The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.
|
THRB-RXRB complex
|
|
TIAM1-EFNB1-EPHA2 complex
|
|
TIAM1-GRIN1 complex
|
|
Tiam1-Par-3-aPKC-zeta complex
|
|
TICAM1-TICAM2-TLR4 complex
|
|
TIF-IB complex
|
|
TIF1gamma-SMAD2-SMAD3 complex
|
|
TIM (TIMM17ab, TIMM23, TIMM44) complex, mitochondrial
|
|
TIM (TIMM23, TIMM50) complex, mitochondrial
|
|
TIM (TIMM9, TIMM10) complex, mitochondrial
|
|
TIM50a-coilin complex
|
|
TIM50a-SMN1 complex
|
|
TIMM17-TIMM23 complex
|
|
TIN2 complex
|
|
TIP49-TIP48-BAF53 complex
|
|
TIP5-DNMT-HDAC1 complex
|
|
TIP60 histone acetylase complex
|
A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
|
Tis7-Sin3-Hdac1-Ncor1-Sap30 complex
|
|
TLE-Histone H3 complex
|
|
TLE1 corepressor complex (MASH1 promoter-corepressor complex)
|
|
TLE1 homodimer complex
|
|
TLE1-TLE2 complex
|
|
TLE2 homodimer complex
|
|
Tle3-Aes complex
|
A transcriptional repressor complex that consists of a heterodimer of the proteins Tle3 (also known as Grg3b) and Aes (Grg5), which are homologs of the Drosophila groucho gene product.
|
TMP21-P24 complex
|
|
Tmsb4x-Lims1-Ilk complex
|
|
TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1)
|
|
TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2)
|
|
TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I)
|
|
TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2)
|
|
TNF-alpha/NF-kappa B signaling complex 10
|
|
TNF-alpha/NF-kappa B signaling complex 5
|
|
TNF-alpha/NF-kappa B signaling complex 6
|
|
TNF-alpha/NF-kappa B signaling complex 7
|
|
TNF-alpha/NF-kappa B signaling complex 8
|
|
TNF-alpha/NF-kappa B signaling complex 9
|
|
TNFRSF11A-TRAF6-SRC complex
|
|
TNPO2-RAN-NXF1 complex
|
|
TOP1-PSF-P54 complex
|
|
Toposome
|
|
TorsinA-TorsinB complex
|
|
Tp53-BAK1 complex
|
|
TRAF2-cIAP1/BIRC2 complex
|
|
TRAF2-MALT1 complex
|
|
TRAF2-TRADD complex
|
|
TRAF6 oligomer complex
|
|
TRAF6-MALT1 complex
|
|
Traf6-p62-aPKC complex, RANK-L stimulated
|
|
TRAF6-TAK1 complex
|
|
Transcription elongation factor complex (SUPT5H, CDK9, CCNT1)
|
|
Transcription initiation factor complex (TAF1, TAF5, TAF11, TAF12, TBP)
|
|
Transcription initiation factor complex (TAF5, TAF6, TAF9, TAF11, TBP)
|
|
TRAP complex
|
|
TRAP-SMCC mediator complex
|
|
TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle)
|
|
TRBP containing complex (DICER, TRBP, AGO2, RPL7A, EIF6, MOV10)
|
|
TREX complex
|
The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans.
|
TRF-Rap1 complex I, 2MD
|
|
TRF1 telomere length regulation complex
|
|
TRF1-TIN2 complex
|
|
TRF2-Ku complex
|
|
TRF2-Rap1 complex II
|
|
TRF2-Rap1 complex III
|
|
TRIB3-DDIT3 complex
|
|
TRIKA2 protein kinase complex (TAK1, TAB1, TAB2)
|
|
TRIM27-RB1 complex
|
|
Trip(Br1)-Dp1-E2F1 complex
|
|
Trip(Br2)-Dp1-E2F1 complex
|
|
Tripeptidyl peptidase
|
|
tRNA splicing endonuclease
|
|
TRP1-G alpha-11-IP3R3-CAV1 signaling complex
|
|
Trpc1-dystrophin-alpha1-syntrophin complex
|
|
TRPC1-STIM1-ORAI1 complex
|
|
TRPC1-TRPC3-TRPC7 complex
|
|
TRPC3-TRPC4 channel complex, redox-sensitive
|
|
TRPV5-S100A10-annexin 2 complex
|
|
TRRAP-BAF53-HAT complex
|
|
TSC1-TSC2 complex
|
A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
|
TSG101-VPS37B-VPS28 complex
|
|
TTP-AGO2 complex
|
|
TTP-AGO4 complex
|
|
Tubulin polyglutamylase complex
|
|
Tumor necrosis factor receptor 1 signaling complex
|
|
Ubiquilin-proteasome complex
|
|
Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1)
|
|
Ubiquitin E3 ligase (ASB1, TCEB1, TCEB2, CUL5, RNF7)
|
|
Ubiquitin E3 ligase (ASB12, TCEB1, TCEB2, CUL5, RNF7)
|
|
Ubiquitin E3 ligase (ASB2, TCEB1, TCEB2, CUL5, RNF7)
|
|
Ubiquitin E3 ligase (ASB6, TCEB1, TCEB2, CUL5, RNF7)
|
|
Ubiquitin E3 ligase (ASB7, TCEB1, TCEB2, CUL5, RNF7)
|
|
Ubiquitin E3 ligase (BMI1, SPOP, CUL3)
|
|
Ubiquitin E3 ligase (CDC34, CUL1, RBX1)
|
|
Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1)
|
|
Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1)
|
|
Ubiquitin E3 ligase (CHEK1, CUL1)
|
|
Ubiquitin E3 ligase (CHEK1, CUL4A)
|
|
Ubiquitin E3 ligase (CRY1, SKP1A, CUL1, FBXL3)
|
|
Ubiquitin E3 ligase (CRY2, SKP1A, CUL1, FBXL3)
|
|
Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3)
|
|
Ubiquitin E3 ligase (CUL1, RBX1, SKP1A)
|
|
Ubiquitin E3 ligase (DDB1, CUL4A, RBX1)
|
|
Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1)
|
|
Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1)
|
|
Ubiquitin E3 ligase (Fbxl20, Skp1, Cul1)
|
|
Ubiquitin E3 ligase (Fbxo15, Cul1, Skp1a)
|
|
Ubiquitin E3 ligase (FBXO18, SKP1A, CUL1, RBX1)
|
|
Ubiquitin E3 ligase (Fbxo2, Skp1a, Cul1, Rbx1)
|
|
Ubiquitin E3 ligase (FBXO31, SKP1A, CUL1, RBX1)
|
|
Ubiquitin E3 ligase (Fbxo32, Skp1a, Cul1, Rbx1)
|
|
Ubiquitin E3 ligase (FBXW11, SKP1A, CUL1, RBX1)
|
|
Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1)
|
|
Ubiquitin E3 ligase (GLMN, FBXW8, SKP1A, RBX1)
|
|
Ubiquitin E3 ligase (H2AFY, SPOP, CUL3)
|
|
Ubiquitin E3 ligase (Neurl2, Tceb1, Tceb2, Cul5, Rbx1)
|
|
Ubiquitin E3 ligase (NFKBIA, BTRC, CUL1, SKP1A)
|
|
Ubiquitin E3 ligase (NFKBIA, FBXW11, BTRC, CUL1, SKP1A)
|
|
Ubiquitin E3 ligase (NFKBIA, FBXW11, CUL1, SKP1A)
|
|
Ubiquitin E3 ligase (NIPA, SKP1A, CUL1, RBX1)
|
|
Ubiquitin E3 ligase (SIAH1, SIP, SKP1A, TBL1X)
|
|
Ubiquitin E3 ligase (SKP1A, BTRC, CUL1)
|
|
Ubiquitin E3 ligase (SKP1A, FBXW2, CUL1)
|
|
Ubiquitin E3 ligase (SKP1A, FBXW8, CUL7, RBX1)
|
|
Ubiquitin E3 ligase (SKP1A, SKP2, CUL1)
|
|
Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1)
|
|
Ubiquitin E3 ligase (Skp1A, Skp2, Cul1, Rbx1)
|
|
Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1)
|
|
Ubiquitin E3 ligase (SPOP, DAXX, CUL3)
|
|
Ubiquitin E3 ligase (TRIM25, DDX58)
|
|
Ubiquitin E3 ligase (UBADC1, RNF123)
|
|
Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2)
|
|
Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1)
|
|
Ubiquitin E3 ligase (WSB1, TCEB1, TCEB2, CUL5, RBX1)
|
|
Ubiquitin ligase complex (TRAF6, TAB2, MALT1, UEV1A, BCL10)
|
|
Ubiquitin-protein ligase (UBE2N, UBE2V2/MMS2)
|
|
Ubiquitin-protein-ligase (UBE2N, UBE2V2/MMS2)
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uKHC-KLC1-KLC2 kinesin complex
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ULBP1-KLRK1-HCST complex
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ULBP2-KLRK1-HCST complex
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ULBP3-KLRK1-HCST complex
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Upf complex (UPF1, UPF2, UPF3a)
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Upf complex (UPF1, UPF2, UPF3b)
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URI complex (Unconventional prefoldin RPB5 Interactor)
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USP1-UAF1 complex
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UTM-SGCE-DAG1-CAV1-NOS3 complex
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UTX-MLL2/3 complex
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VAM1-VELI1 complex
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Vdr-Med4 complex
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VEGF transcriptional complex
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VEGFA(165)-KDR-NRP1 complex
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VEGFA(165)-VEGFR2-NRP1 complex
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Vezf1-p68RacGap complex
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VHL-TBP1-HIF1A complex
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VHL-TCEB1-TCEB2 complex
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VHL-VDU1-TCEB1-TCEB2 complex
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Vigilin-DNA-PK-Ku antigen complex
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VILIP-1-AChR-alpha-4-AChR-beta-2 complex
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Vps29-Vps35-Vps26a complex
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VPS35-VPS29-VPS26A complex
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Wave-2 complex
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Wave-2 complex (Rac-activated)
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Wave1-Bcl-xl-Pancortin-2 complex, focal ischemic stroke induced
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WCRF complex
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WDR5-ASH2L-RBBP5-MLL2 complex
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Whrn homodimer complex
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WICH complex
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An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and WSTF (Williams Syndrome Transcription Factor). WICH plays roles in regulation of RNAP I and III transcription and in DNA replication and repair.
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WINAC complex
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WIP-WASp-actin-myosin-IIa complex
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WNK1-OSR1 complex
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WNK1-SPAk complex
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WRN-Ku70-Ku80-PARP1 complex
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WRN-TRF2 complex
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XFIM complex
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Xin-Cdh2-Ctnnb1-Ctnnd1 complex
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XPA-ERCC1-ERCC4 complex
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One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively.
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XRCC1-LIG3-PNK-TDP1 complex
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Y14-Magoh complex
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YBX1-AKT1 complex
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YWHAQ-CALM1-CABIN1 complex
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YY1-MDM2-p53 complex
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YY1-Notch1 complex
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YY1-Notch1-RBP-Jkappa complex
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Yy1-Ppargc1a complex
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Yy1-Ppargc1a-Frap1 complex
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ZAP70-CRKL-WIPF1-WAS complex
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ZNF198-PML complex
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ZNF198-SUMO1 complex
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ZO1-(beta)cadherin-(VE)cadherin-VEGFR2 complex
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