DeepCoverMOA Drug Mechanisms of Action Dataset

Description protein expression profiles in HCT116 cell line following drug treatment
Measurement protein expression by mass spectrometry
Association gene-small molecule associations by differential expression of gene following small molecule perturbation
Category proteomics
Resource DeepCoverMOA
Citation(s)
Last Updated 2023 Mar 06
Stats
  1. 8405 genes
  2. 874 small molecule perturbations
  3. 260471 gene-small molecule perturbation associations

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  • Gene Similarity

  • Attribute Similarity

  • UMAP

small molecule perturbation Gene Sets

874 sets of proteins with high or low expression relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

Gene Set Description
(4-Chlorobenzyl)pyridine
(RS)-PPG
(S)-(-)-Pindolol
(S)-Selisistat
(S)-Zopiclone
(Z)-Pugnac
1,4-DHNA
10074-G5
2,2'-Biquinoline
2,4-Dichlorophenol
2,6-Dichlorophenethylamine
2-Bromophenethylamine
2-Cl-IB-MECA
2-PMPA
3,5-Dichlorosalicylic acid
3-Benzotriazol-propionic acid
3-Benzyloxyaniline
3-Deazaneplanocin A
3-Hydroxyflavone
4,4'-Dichlorobenzil
4,4'-Dimethoxybenzil
4-Aminobenzohydrazide
4-Benzylpyridine
4-Methoxybenzoic acid
4-Methylhistamine
4-Nitropiazthiole
4EGI-1
4mu8C
5-Ethynyluracil
5-Hydroxyflavone
5-R-Rivaroxaban
6-Aminochrysene
6-Mercaptopurine
6603-0104
7,3,4-THIF
7,8-Dihydroxyflavone
7-Hydroxycoumarine
9-Aminocamptothecin
A 1120
A 438079
A 803467
A 922500
A 967079
A-317491
a-Naphthoflavone
AA92593
Abemaciclib
Abiraterone1
Abiraterone2
ABL127
ABT-199
ABT-737
AC-7954
Ac-YVAD-CHO
ACA
Acamprosate
Acenaphthoquinone
Acetazolamide
Acifran
Acitretin
Actinonin
Actonel
AGI-6780
AGK2
AGN 190299
AK 7
AK-54059
AKR1C3-IN-1
Alectinib
Alfuzosin
Aliskiren
Alogliptin
Alosetron
alvimopan
AM 630
AM095
AM966
AMG 487
AMN 082
Amsacrine
Anacetrapib
Anagrelide
Anamorelin
Anastrozole
APD668
Aprepitant
AQ-390/43364023
AR-C155858
Aripiprazole
ARL 17477
AS 1517499
AS-605240
Asarone
Ascomycin
Asimadoline
AT 406
Atglistatin
Atomoxetine
Atosiban
AUDA
Avosentan
AXL1717
AZ 628
AZ20
AZ505
AZD 6482
AZD-5438
AZD1152
AZD1152-HQPA
AZD4547
AZD7762
AZD8055
Azilsartan
Aztreonam
BACE1_In
Bafetinib
Bafilomycin A1
Balicatib
Baricitinib
Basimglurant
BAY 57-1293
Bay 60-7550
BAY 61-3606
BBL003126
BBL023172
BCATc-In2
BCX 1470
BD 1008
BEC
Benethamine
Benzbromarone
Benzo[a]pyrene
Bergenin
Berzosertib
Bestatin
Betamethasone
Bexarotene
BHT
BI 2536
Bicifadine
Binospirone
Birabresib
Bisphenol A
BIX 01294
Blonanserin
BLZ-945
BML-277
BMS 303141
BMS 754807
BMS-5
BMS-536924
BMS-911543
BMS309403
BMY 7378
Boc-4mesyloxypiperidine
Bombesin
Bosentan
Bosutinib
BQ-788
Brequinar
BRL 54443
Bromfenac
Bromopyruvic acid
BS-181
Buspirone
BW 723C86
BX 471
BX 912
c-Fms-IN-3
CA-074
CAL-101
Calcipotriol
Capsazepine
Carbamazepine
Carprofen
Carvedilol
Castanospermine
CAY10550
CAY10650
CAY10683
CB 13
CB-839
CBIO
CBL0137
CC-401
CCT128930
CCT241533
Cediranib
Celastrol
Ceritinib
Cetirizine
Cetrorelix
CGP77675
CGS 35066
CH-223191
CH5132799
CHCA
CHEMBL1348080
CHEMBL1436068
CHEMBL1597046
CHEMBL1643306
CHEMBL1902935
CHEMBL200403
CHEMBL2041153
CHEMBL217125
CHEMBL2172374
CHEMBL2397099
CHEMBL2431803
CHEMBL383736
CHEMBL513147
CHEMBL569227
CHEMBL570596
Chloro-L-alanine
Chlorsulfuron
CID-2745687
Cilengitide
Cilostamide
Cimetidine
CJ-42794
Climbazole
Cloprostenol
Clorgiline
Clozapine
Compound-1a
conivaptan
CP 94253
CP-673451
CPI-203
Crizotinib
Cyanuric chloride
Cyclopamine
CyPPA
Cysmethynil
Cytosporone B
CZC-25146
D-(+)-Glucose
D-3263
D399-0002
Dabigatran
Dantrolene
Dapagliflozin
Dapiprazole
Darapladib
Darifenacin
Darunavir
Dasatinib
Debio-1347
Defactinib
Desipramine
Desvenlafaxine
Dexrazoxane
Dichlorisone
Dichlorphenamide
Dicumarol
Dicyclohexylamine
Diethylstilbestrol
Dihydroartemisinin
Dimethylfraxetin
Dinoprost
Dipyridamole
DMB
Dopamine
Doramapimod
Dorzolamide
DP-agonist13
DPP-IV-IN-2
Dronedarone
Duvelisib
DY 131
EIPA
Eletriptan
Eltrombopag
Encorafenib
Eniporide
Entinostat
Entospletinib
Enzalutamide
Enzastaurin
Eplerenone
Epoxomicin
Epristeride
Eptifibatide
EPZ-6438
EPZ004777
Erlotinib
Erythromycin
Esmolol
Ethiprole
Ethoxzolamide
Ethynyl Estradiol
Evacetrapib
EWP-815
Ezatiostat
Febuxostat
Fedratinib
Fenoldopam
Fevipiprant
Filanesib
Finasteride
Fingolimod
FIPI HCl
FK866
Flavopiridol
Fluconazole
Fluorescein
Fluoxymesterone
Fluticasone
FMK
fMLF
Formestane
Forodesine
FR 180204
FTI-277
Fumagillin
Fumitremorgin C
G-1
Gandotinib
GBR 12909
Gedatolisib
Gefitinib
Genistein
Ginkgolide A
GK01981
Gliclazide
Glufosinate
Glycyrrhizic acid
GNE-9605
GNF-5
GR79236
GS-9620
GSK 650394
GSK-1070916
GSK-923295
GSK-LSD1
GSK126
GSK189254A
GSK2334470
GSK2578215
GSK2606414
GSK2636771
GSK2656157
GSK343
GSK4112
GSK429286A
Guanethidine
Guanfacine
GW 3965
GW 441756
GW 501516
GW311616
GW4064
GW7647
GW842166X
GW9508
H 89
H-1152
H-Arg(NO2)-OH
HA130
HC 030031
HC 067047
HFI-142
HhAntag
Histamine
HJC0350
HMB-Val-Ser-Leu-VE
HMS3745G19
HPGDS-In1
Huperzine A
HX 531
HY-50713
I3C
IBC 293
Ibrutinib1
Ibrutinib2
Ibutamoren
Ibutilide
IC-87114
Icatibant
ICG-001
Iclaprim
Icotinib
Idasanutlin
Iloprost
Imiquimod
INCB 3284
Indapamide
Indomethacin
Ingenol-3-angelate
INT-747
IRAK-1-4 Inhibitor I
ISO-1
Isoproterenol
Isotretinoin
Ispinesib
IU1
Ivabradine
Ivacaftor
IWR-1
JNJ-38877605
JP1302
JQ-1
JTE 013
JW 480
JZL 184
Kaempferide
kb NB 142-70
KH-CB19
KH7
KM03430
ko143
KPT-330
KU 55933
KU-60019
L-165041
L-168,049
L-741
L-779450
L-Cysteine
L-Menthol
L-Mimosine
L-NIL
L-Valyl-L-phenylalanine
L755507
Lalistat1
Lapatinib
Laropiprant
Lasmiditan
LCL161
LDN-192960
Leupeptin
Levosimendan
Linagliptin
Lixivaptan
LOMEGUATRIB
Lomitapide
Lorcaserin
LP-533401
LPA2 An1
LUBIPROSTONE
LUF-5735
LXR-623
LY 344864
LY 364947
LY 487379
LY2090314
LY2365109
LY2584702
LY2801653
LY334370
LY411575
Macitentan
Maraviroc
Mardepodect
Marimastat
Mavorixafor
MBX-2982
MEK162
Meloxicam
MERCK544
Methazolamide
Methylnaltrexone
Metolazone
Metyrapone
MF63
MG-132
MI-3
MI-773
Mianserin
Midostaurin
Mifepristone
Migalastat
Mildronate
Milrinone
Minocycline
Mirabegron
MK 886
MK-1775
MK-3207
MK-6892
MK2206
ML-265
ML-323
mL167
ML218
ML221
mL347
ML349
ML365
MLN 8237
MLN4924
MLS0315771
MN-64
Molindone
Momelotinib
Montelukast
Moxonidine
MPI-0479605-HCL
MRE-269
MRS 1754
MRS 2578
Mubritinib
Mycophenolic acid
N6022
Nafamostat
Nateglinide
Navarixin
NB-598
NBI-74330
NBTGR
NDT 9513727
Necrostatin 2
Neurokinin A
Nexturastat A
NFPS
NIBR189
Nifedipine
Nilotinib
Nisoldipine
Nitisinone
NMS-873
NNC 26-9100
Nolatrexed
NP118809
NS 3763
NS309
NSC 23766
NSC 87877
NSC19883
NSC43673
NSC735380
NSC95682
NU 7026
NU7441
Nutlin3a
NVP-BEP800
NVP-BHG712
NVP-BSK805
Obatoclax
Octreotide
Odanacatib
Olanzapine
Olaparib
Olcegepant
Oleanolic Acid
Olodaterol
Olopatadine
Olvance
ONX 0914
Org25543
Orteronel
OSI-027
Osilodrostat
Ospemifene
OSU-03012
OTSSP167
Ozagrel
p-Tolylboronic acid
P005091
PAC-1
Palbociclib
Paliperidone
Palonosetron
Pamidronic acid
Pamoic Acid
PAP-1
Papaverine
Parecoxib
Paricalcitol
Paroxetine
Pazopanib
PCI-34051
PD 123319
PD 160170
PD 176252
PD173212
PDE-9i
PDK1-In
Pentadecanoyl EA
Pepstatin A
Perhexiline
Perindopril
PF 04447943
PF 4800567
PF-04418948
PF-04620110
PF-3758309
PF-431396
PF-514273
PF-543
PF-8380
PF429242
PHA 767491
Phenylboronic acid
Pictilisib
Pimavanserin
Pinometostat
Pirenzepine
Pitolisant
PJ34
PLX-4720
PNU-120596
Pomalidomide
PP 1
PP2
Pramipexole
Prinomastat
Probenecid
Progesterone
PRT062607
Prucalopride
PRX-08066
PS-1145
Purvalanol
PX-12
Pyrene
Pyrimethamine
QNZ
Quetiapine
Quiflapon
Quinidine
Quisinostat
Quizartinib
QX 314
R-848
R121919
Racecadotril
Radicicol
Ralfinamide
Raloxifene
Ramelteon
Repaglinide
Resmetirom
Retigabine
Reversine
RF9
RG2833
RGFP966
RH00511
Rhodanine derivative38
Ribociclib
Rifampicin
Rifaximin
Rimonabant
Ripasudil
Rislenemdaz
Rivastigmine
RK-24466
RN-1734
RN486
Ro 28-1675
Ro 48-8071
Ro-3306
RO495
Rofecoxib
Roflumilast
Rolapitant
Rosiglitazone
Rotigotine
Roxatidine
RRD-251
RS 67333
Ruboxistaurin
Rucaparib
Rucinol
Rupatadine
Ruxolitinib
RVX-208
RWJ 50271
S107
Salmeterol
Sapropterin
SAR020106
SAR7334
Saracatinib
SB 216763
SB 218795
SB 225002
SB 334867
SB 525334
SB 699551
SB-222200
SB-224289
SB-269970
SB-408124
SB-674042
SB290157
SC 560
SCH 530348
SCH 58261
SCHEMBL5061501
SD-208
Selisistat
Senicapoc
Seratrodast
SGC0946
SGI-1776
SH-4-54
Sildenafil
Silmitasertib
Silodosin
Simvastatin
Siponimod
Sitagliptin
Sitaxsentan
SKF 89976A
SKI II
SMI-16a
Sotrastaurin
SP2509
SP600125
Spautin-1
SPB06189
Spironolactone
SR 11237
SR 142948
SR 27897
SR 3335
SSR 69071
SSR128129E
STF-31
Stiripentol
STK066844
STK155799
STK235555
STK368746
STK410281
STK410283
STK416816
STK746869
STK772817
STK832240
STK841699
STK869906
STL304557
STL321288
STL336112
STX-0119
Succinobucol
Sulcotrione
Sulfanilamide
Sulforaphane
Sultiame
Sumatriptan
Sunitinib
T-00127_HEV1
T3
Tacrine
Tacrolimus
Tadalafil
TAE 226
Tafamidis
Tafluprost
TAK-285
TAK-779
TAK-875
Talazoparib
Tamibarotene
Tandutinib
Tanomastat
Taranabant
Tasimelteon
Tazarotene1
Tazarotene2
TC-N 22A
TC-O 9311
TCS 1102
TCS ERK 11e
TCS PIM-1 1
TCS-OX2-29
Teijin compound 1
Telmisartan
Telotristat
Terazosin
Terbinafine
Testolactone
Tetrindole
Tezacaftor
TGX-221
Thiamet G
Thiothixene
Thymidine
Tiagabine
Ticagrelor
Tideglusib
Timapiprant
Tipifarnib
Tipiracil
Tiplaxtinin
Tirofiban
Tivozanib
Tizanidine
TMN 355
TMP269
TNP-470
Toceranib
TOFA
Tofacitinib
Tolimidone
Tolvaptan
Topiramate
Torasemide
Torcetrapib
Tozasertib
TPCA-1
TPPB
TR-14035
TRAM-34
Tranexamic acid
Treprostinil
Triclabendazole
Trihydroxyisoflavone
Tropicamide
Tubastatin A
Turofexorate
UAMC00039
UK 356618
UK 383367
Ulipristal
UMI-77
UNC 0631
UNC 0638
UNC1215
UNC2250
UNC2881
Undecanoic acid
UPF 648
Uridine
Ursodiol
Varespladib
Vatalanib
VE-821
Veliparib
Vemurafenib
Vernakalant
Vicriviroc
Vidofludimus
Vilazodone
Volasertib
Vorinostat
VPC23019
VTP-27999
VU 0364439
VU 0364739
VU0152100
VUF11207
W-13 HCl
WAY 170523
WAY 316606
WH-4-023
WZ811
XAV 939
XCT 790
XEN 103
XEN445
Y-33075
YK-4-279
Yohimbine
Z32036776
Zafirlukast
Zaltoprofen
ZD 7288
Zebularine
ZINC2093649
ZINC6198410
ZINC8945
Ziprasidone
ZJ 43
ZM 241385
ZM 336372
Zofenopril
Zonisamide
Zosuquidar
Zotarolimus
[Pyr1]-Apelin-13