| Description | Curated annotations of genes with molecular functions |
| Measurement | association by literature curation |
| Association | gene-molecular function associations from curated gene annotations |
| Category | structural or functional annotations |
| Resource | Gene Ontology |
| Citation(s) | |
| Last Updated | 2015 Mar 31 |
| Stats |
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Attribute Similarity
Gene Attribute
Gene Similarity
4162 sets of genes performing molecular functions from the curated GO Molecular Function Annotations 2015 dataset.
| Gene Set | Description |
|---|---|
| n-acetyl-beta-glucosaminyl-glycoprotein 4-beta-n-acetylgalactosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group. |
| translation activator activity | Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide. |
| ubiquitinyl hydrolase activity | Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin. |
| syntaxin-3 binding | Interacting selectively and non-covalently with the SNAP receptor syntaxin-3. |
| taurine:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in). |
| udp-sugar diphosphatase activity | Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate. |
| polynucleotide adenylyltransferase activity | Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. |
| neurotrophin receptor binding | Interacting selectively and non-covalently with a neurotrophin receptor. |
| peroxisome membrane class-1 targeting sequence binding | Interacting selectively and non-covalently with a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner. |
| sulfur amino acid transmembrane transporter activity | Catalysis of the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives. |
| glycolipid mannosyltransferase activity | Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage. |
| transcription coactivator activity | Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. |
| succinate-semialdehyde dehydrogenase binding | Interacting selectively and non-covalently with succinate-semialdehyde dehydrogenase. |
| glutathione dehydrogenase (ascorbate) activity | Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide. |
| oxidoreductase activity, acting on the ch-nh group of donors, quinone or similar compound as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound. |
| pyrimidine-specific mismatch base pair dna n-glycosylase activity | Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site. |
| glycoprotein-fucosylgalactoside alpha-n-acetylgalactosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose. |
| nucleotide binding | Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
| transferase activity, transferring one-carbon groups | Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). |
| guanylate kinase activity | Catalysis of the reaction: ATP + GMP = ADP + GDP. |
| activating transcription factor binding | Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription. |
| ethanol binding | Interacting selectively and non-covalently with ethanol, CH(3)-CH(2)-OH. |
| carboxy-lyase activity | Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. |
| kynureninase activity | Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine. |
| diacylglycerol kinase activity | Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate. |
| vascular endothelial growth factor receptor 2 binding | Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2. |
| dynein binding | Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules. |
| polyamine binding | Interacting selectively and non-covalently with polyamines, organic compounds containing two or more amino groups. |
| vasopressin receptor binding | Interacting selectively and non-covalently with a vasopressin receptor. |
| serine hydrolase activity | Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| atp-dependent polynucleotide kinase activity | Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. |
| phosphoribosylformylglycinamidine synthase activity | Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate. |
| phosphate ion transmembrane transporter activity | Catalysis of the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other. |
| selenide, water dikinase activity | Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate. |
| ciliary neurotrophic factor receptor binding | Interacting selectively and non-covalently with the ciliary neurotrophic factor receptor. |
| inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts. |
| carbon-carbon lyase activity | Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. |
| large conductance calcium-activated potassium channel activity | Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. |
| tryptophan-trna ligase activity | Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). |
| leukemia inhibitory factor receptor binding | Interacting selectively and non-covalently with the leukemia inhibitory factor receptor. |
| titin binding | Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively. |
| myosin ii heavy chain binding | Interacting selectively and non-covalently with a heavy chain of a myosin II complex. |
| ligase regulator activity | Modulates the activity of a ligase. |
| aspartic-type endopeptidase inhibitor activity | Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. |
| mhc class ib protein binding, via antigen binding groove | Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules via the antigen binding groove. |
| interleukin-8 receptor activity | Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| protein disulfide isomerase activity | Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. |
| ige receptor activity | Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| thymidine kinase activity | Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. |
| cholesterol 7-alpha-monooxygenase activity | Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O. |
| dinucleotide repeat insertion binding | Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats. |
| phosphotransferase activity, paired acceptors | Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors. |
| cyclic-gmp-amp binding | Interacting selectively and non-covalently with cyclic-GMP-AMP (cGAMP) cyclic nucleotide. |
| l-glutamine:pyruvate aminotransferase activity | Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine. |
| formate uptake transmembrane transporter activity | Catalysis of the transfer of formate from the outside of a cell to the inside of the cell across a membrane. |
| cytidine deaminase activity | Catalysis of the reaction: cytidine + H2O = uridine + NH3. |
| hydroxymethylglutaryl-coa lyase activity | Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA. |
| interleukin-12 receptor binding | Interacting selectively and non-covalently with the interleukin-12 receptor. |
| jun kinase activity | Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors. |
| gastrin receptor activity | Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. |
| heterotrimeric g-protein binding | Interacting selectively and non-covalently with a heterotrimeric G-protein. |
| alpha1-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. |
| melanin-concentrating hormone activity | The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals. |
| carbonyl reductase (nadph) activity | Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+. |
| ditp diphosphatase activity | Catalysis of the reaction: dITP + H2O = dIMP + diphosphate. |
| n1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity | Catalysis of the reaction: H(2)O + N(1)-acetylspermidine + O(2) = 3-acetamidopropanal + H(2)O(2) + putrescine. |
| lbd domain binding | Interacting selectively and non-covalently with the LBD, the ligand binding domain found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket. |
| ufm1 transferase activity | Catalysis of the transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y --> Y-UFM1 + X, where both X-UFM1 and Y-UFM1 are covalent linkages. |
| dopachrome isomerase activity | Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate. |
| sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity | Catalysis of the reaction: sn-glycerol 3-phosphate + a ubiquinone = glycerone phosphate + a ubiquinol. |
| myosin light chain binding | Interacting selectively and non-covalently with a light chain of a myosin complex. |
| oxidoreductase activity, acting on superoxide radicals as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor. |
| gtp binding | Interacting selectively and non-covalently with GTP, guanosine triphosphate. |
| protein binding involved in cell-matrix adhesion | Any protein binding that is involved in cell-matrix adhesion. |
| deoxyribonuclease activity | Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. |
| fatty acid ligase activity | Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP. |
| 3'-nucleotidase activity | Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate. |
| acetylcholine receptor regulator activity | Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor. |
| 5(s)-hydroxyperoxy-6e,8z,11z,14z-icosatetraenoic acid binding | Interacting selectively and non-covalently with 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. |
| phosphatidylglycerophosphatase activity | Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate. |
| kainate selective glutamate receptor activity | An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist. |
| intracellular calcium activated chloride channel activity | Catalysis of the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. |
| rna polymerase i transcription factor recruiting transcription factor activity | The function of binding to an RNA polymerase I (RNAP I) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP I. |
| methylenetetrahydrofolate dehydrogenase [nad(p)+] activity | |
| methylmalonate-semialdehyde dehydrogenase (acylating) activity | Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. |
| 15-oxoprostaglandin 13-oxidase activity | Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+. |
| hedgehog receptor activity | Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity. |
| guanosine-diphosphatase activity | Catalysis of the reaction: GDP + H2O = GMP + phosphate. |
| atp-activated inward rectifier potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. |
| edg-2 lysophosphatidic acid receptor binding | Interacting selectively and non-covalently with an Edg-2 lysophosphatidic acid receptor. |
| histone serine kinase activity | Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. |
| arginase activity | Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea. |
| purinergic nucleotide receptor activity | Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| chloride channel activity | Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| glycerophosphoinositol inositolphosphodiesterase activity | Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol. |
| iodide transmembrane transporter activity | Catalysis of the transfer of iodide ions from one side of a membrane to the other. |
| n-acetyllactosaminide beta-1,3-n-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. |
| signal transducer activity | Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. |
| kynurenine 3-monooxygenase activity | Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+). |
| glycine transmembrane transporter activity | Catalysis of the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid. |
| 4-hydroxybenzoate nonaprenyltransferase activity | Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + diphosphate. |
| l-gulonate 3-dehydrogenase activity | Catalysis of the reaction: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH. |
| lysophosphatidic acid phosphatase activity | Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol. |
| peroxidase activity | Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O. |
| cofactor transporter activity | Enables the directed movement of a cofactor into, out of or within a cell, or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein. |
| lysine-acetylated histone binding | Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation. |
| cysteamine dioxygenase activity | Catalysis of the reaction: cysteamine + O(2) = H(+) + hypotaurine. |
| type i activin receptor binding | Interacting selectively and non-covalently with a type I activin receptor. |
| microfilament motor activity | Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). |
| tryptophan 5-monooxygenase activity | Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O. |
| fatty acid binding | Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. |
| activin binding | Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits. |
| ornithine decarboxylase inhibitor activity | The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase. |
| structural molecule activity | The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. |
| v1a vasopressin receptor binding | Interacting selectively and non-covalently with a V1A vasopressin receptor. |
| phospholipase activator activity | Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid. |
| rna polymerase iii regulatory region dna binding | Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. |
| nuclear hormone receptor binding | Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell. |
| dna-7-methylguanine glycosylase activity | Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site. |
| ubiquitin-specific protease binding | Interacting selectively and non-covalently with a ubiquitin-specific protease. |
| aminoacetone:oxygen oxidoreductase(deaminating) activity | Catalysis of the reaction: aminoacetone + H2O + O2 = methylglyoxal + NH3 + hydrogen peroxide + H+. |
| udp-xylose transmembrane transporter activity | Catalysis of the transfer of UDP-xylose from one side of the membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate. |
| gdp-dissociation inhibitor binding | Interacting selectively and non-covalently with a GDP-dissociation inhibitor protein. |
| cyclase regulator activity | Modulates the activity of an enzyme that catalyzes a ring closure reaction. |
| mdm2/mdm4 family protein binding | Interacting selectively and non-covalently with any isoform of the MDM2/MDM4 protein family, comprising negative regulators of p53. |
| 4-aminobutyrate transaminase activity | Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid. |
| stem cell factor receptor activity | Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation. |
| thymine binding | Interacting selectively and non-covalently with thymine. |
| o-phospho-l-serine:2-oxoglutarate aminotransferase activity | Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. |
| hepatocyte growth factor binding | Interacting selectively and non-covalently with a hepatocyte growth factor. |
| vascular endothelial growth factor receptor 1 binding | Interacting selectively and non-covalently with vascular endothelial growth factor receptor 1. |
| alpha-1,3-glucosidase activity | Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->3)-linked alpha-D-glucose residues with release of alpha-D-glucose. |
| adenylate cyclase activity | Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. |
| progesterone receptor binding | Interacting selectively and non-covalently with a progesterone receptor. |
| dolichol kinase activity | Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate. |
| fatty acid alpha-hydroxylase activity | Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain. |
| retinal dehydrogenase activity | Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal. |
| amino acid kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate. |
| adenine binding | Interacting selectively and non-covalently with adenine, a purine base. |
| neuropeptide receptor activity | Combining with a neuropeptide to initiate a change in cell activity. |
| t cell receptor binding | Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells. |
| tapasin binding | Interacting selectively and non-covalently with tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules. |
| thyrotropin-releasing hormone receptor activity | Combining with thyrotropin-releasing hormone to initiate a change in cell activity. |
| mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity | Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3). |
| propanoyl-coa c-acyltransferase activity | Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA. |
| olfactory receptor activity | Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. |
| l-serine ammonia-lyase activity | Catalysis of the reaction: L-serine = pyruvate + NH3. |
| protein methylesterase activity | Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol. |
| s-methylmethionine-homocysteine s-methyltransferase activity | Catalysis of the reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H+. |
| intramolecular oxidoreductase activity, interconverting aldoses and ketoses | Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. |
| 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-coa 24-hydroxylase activity | Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor. |
| cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
| structural constituent of ribosome | The action of a molecule that contributes to the structural integrity of the ribosome. |
| thiomorpholine-carboxylate dehydrogenase activity | Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate. |
| monosaccharide transmembrane transporter activity | Catalysis of the transfer of a monosaccharide from one side of a membrane to the other. |
| l-proline transmembrane transporter activity | Catalysis of the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid. |
| 5'-3' exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule. |
| interleukin-18 receptor activity | Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| methylthiotransferase activity | Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor. |
| androgen receptor binding | Interacting selectively and non-covalently with an androgen receptor. |
| protein histidine kinase activity | Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. |
| acetyl-coa transporter activity | Enables the directed movement of acetyl-CoA into, out of or within a cell, or between cells. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. |
| thiamine phosphate phosphatase activity | Catalysis of the hydrolysis of thiamine phosphate. |
| hydroxyacylglutathione hydrolase activity | Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. |
| tyrosine binding | Interacting selectively and non-covalently with2-amino-3-(4-hydroxyphenyl)propanoic acid. |
| protein transmembrane transporter activity | Catalysis of the transfer of a protein from one side of a membrane to the other. |
| fat10 activating enzyme activity | Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond. |
| binding | The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. |
| proline-rich region binding | Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein. |
| methylenetetrahydrofolate dehydrogenase (nad+) activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH. |
| phosphate ion binding | Interacting selectively and non-covalently with phosphate. |
| transferase activity, transferring pentosyl groups | Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). |
| chondroitin-glucuronate 5-epimerase activity | Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate. |
| neurohypophyseal hormone activity | The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin. |
| nadph binding | Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
| cysteine-type endopeptidase activator activity involved in apoptotic process | Increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process. |
| endocytic adaptor activity | The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex as a key step in receptor mediated endocytosis. |
| wnt-activated receptor activity | Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| telomeric dna binding | Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. |
| c-c motif chemokine 21 receptor activity | Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| threonine aldolase activity | Catalysis of the reaction: L-threonine = glycine + acetaldehyde. |
| 6-phosphofructokinase activity | Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate. |
| nerve growth factor binding | Interacting selectively and non-covalently with nerve growth factor (NGF). |
| putrescine transmembrane transporter activity | Catalysis of the transfer of putrescine from one side of the membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. |
| coenzyme transporter activity | Enables the directed movement of a coenzyme into, out of or within a cell, or between cells. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. |
| tfiib-class binding transcription factor activity | Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well. |
| dna nucleotidylexotransferase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). |
| nucleoside phosphotransferase activity | Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate. |
| [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity | Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S. |
| receptor antagonist activity | Interacts with receptors to reduce the action of another ligand, the agonist. |
| phosphotyrosine binding | Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein. |
| n1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity | Catalysis of the reaction: H(2)O + N(1)-acetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + spermidine. |
| aldehyde oxidase activity | Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide. |
| bh4 domain binding | Interacting selectively and non-covalently with the BH4 domain of a protein of the Bcl-2 family. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein. |
| dodecenoyl-coa delta-isomerase activity | Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA. |
| atp-binding and phosphorylation-dependent chloride channel activity | Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts. |
| phosphoprotein binding | Interacting selectively and non-covalently with a phosphorylated protein. |
| steroid receptor rna activator rna binding | Interacting selectively and non-covalently with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding. |
| protein binding, bridging | The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. |
| xanthine dehydrogenase activity | Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+. |
| receptor binding | Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
| nucleoside phosphate kinase activity | Catalysis of the reaction: ATP + nucleoside phosphate = ADP + nucleoside diphosphate. |
| substrate-specific transporter activity | Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. |
| nitrate transmembrane transporter activity | Catalysis of the transfer of nitrate ions (NO3-) from one side of a membrane to the other. |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines | Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. |
| hepoxilin a3 synthase activity | Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3. |
| proteasome binding | Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation. |
| (r)-limonene 6-monooxygenase activity | Catalysis of the reaction: (4R)-limonene + H+ + NADPH + O2 = (1R,5S)-carveol + H2O + NADP+. |
| glucocorticoid receptor activity | Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function. |
| 3-hydroxybutyrate dehydrogenase activity | Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH. |
| sodium:chloride symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in). |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity | An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium. |
| phospholipid scramblase activity | Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism. |
| small molecule binding | Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule. |
| beta-catenin binding | Interacting selectively and non-covalently with the beta subunit of the catenin complex. |
| mannose transmembrane transporter activity | Catalysis of the transfer of mannose from one side of the membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. |
| actin monomer binding | Interacting selectively and non-covalently with monomeric actin, also known as G-actin. |
| hexose transmembrane transporter activity | Catalysis of the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other. |
| cholinesterase activity | Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion. |
| atpase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction. |
| sphingomyelin phosphodiesterase activator activity | Increases the activity of the enzyme sphingomyelin phosphodiesterase. |
| dynactin binding | Interacting selectively and non-covalently with any part of a dynactin complex; dynactin is a large protein complex that activates dynein-based motor activity. |
| glycolipid 6-alpha-mannosyltransferase activity | Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage. |
| pdz domain binding | Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins. |
| nitrilase activity | Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides. |
| glycosphingolipid binding | Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. |
| nicotinate phosphoribosyltransferase activity | Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate. |
| peptide disulfide oxidoreductase activity | Catalysis of the reaction: a peptide with reduced sulfide groups = a peptide with oxidized disulfide bonds. |
| protein-lipid complex binding | Interacting selectively and non-covalently with a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules. |
| neurexin family protein binding | Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. |
| proton-transporting atpase activity, rotational mechanism | Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. |
| nadp+ binding | |
| histone demethylase activity | Catalysis of the removal of a methyl group from a histone. |
| arsenate reductase activity | Catalysis of the interconversion of arsenate and arsenite. |
| acetylcholine receptor activity | Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| heterocyclic compound binding | Interacting selectively and non-covalently with heterocyclic compound. |
| ethanolaminephosphotransferase activity | Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine. |
| high-affinity l-ornithine transmembrane transporter activity | Catalysis of the transfer of L-ornithine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. |
| symporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
| ribosomal large subunit binding | Interacting selectively and non-covalently with any part of the larger ribosomal subunit. |
| ligase inhibitor activity | Stops, prevents or reduces the activity of a ligase. |
| n-acetyllactosamine synthase activity | Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine. |
| protein phosphatase type 4 regulator activity | Modulation of the activity of the enzyme protein phosphatase type 4. |
| serine o-acyltransferase activity | Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule. |
| fibroblast growth factor binding | Interacting selectively and non-covalently with a fibroblast growth factor. |
| intramolecular lyase activity | The catalysis of certain rearrangements of a molecule to break or form a ring. |
| rna polymerase i regulatory region dna binding | Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase I. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. |
| lipopolysaccharide receptor activity | Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. |
| methyl-cpg binding | Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide. |
| translation elongation factor activity | Functions in chain elongation during polypeptide synthesis at the ribosome. |
| phosphatidate phosphatase activity | Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. |
| nutrient reservoir activity | Functions in the storage of nutritious substrates. |
| endoribonuclease activity, cleaving mirna-paired mrna | |
| nitric-oxide synthase inhibitor activity | Interacts with, and stops, prevents or reduces the activity of nitric oxide synthase. |
| phosphohistidine phosphatase activity | Catalysis of the reaction: phosphohistidine + H2O = histidine + phosphate. |
| neurotransmitter:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). |
| collagen receptor activity | Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| neuropeptide binding | Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). |
| rna polymerase ii basal transcription factor binding transcription factor activity | Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. |
| serine racemase activity | Catalysis of the synthesis of free D-serine from L-serine. |
| type i interferon receptor activity | Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families. |
| calcium-dependent cysteine-type endopeptidase activity | Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. |
| nucleotidase activity | Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. |
| g-protein coupled chemoattractant receptor activity | Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| mannokinase activity | Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate. |
| u5 snrna binding | Interacting selectively and non-covalently with the U5 small nuclear RNA (U5 snRNA). |
| hepatocyte growth factor-activated receptor activity | Combining with hepatocyte growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| acyl-[acyl-carrier-protein] hydrolase activity | Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + a fatty acid. |
| beta-galactoside alpha-2,3-sialyltransferase activity | Catalysis of the transfer of sialyl residues alpha-2,3-linked to a beta galactosyl residue on the donor to form an alpha-2,3 linkage to a terminal beta galactosyl residue on the acceptor. |
| 5'-3' dna helicase activity | Catalysis of the unwinding of the DNA helix in the direction 5' to 3'. |
| translation factor activity, nucleic acid binding | Functions during translation by interacting selectively and non-covalently with nucleic acids during polypeptide synthesis at the ribosome. |
| succinate-coa ligase (gdp-forming) activity | Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate. |
| thrombin receptor activity | Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. |
| pyridoxamine-phosphate oxidase activity | Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide. |
| intracellular camp activated cation channel activity | Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts. |
| protein-arginine deiminase activity | Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3. |
| g-protein coupled purinergic nucleotide receptor activity | Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| sphingolipid delta-4 desaturase activity | Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid. |
| glucoside transmembrane transporter activity | Catalysis of the transfer of glucosides from one side of the membrane to the other. Glucosides are glycosides in which the sugar group is a glucose residue. |
| retinoic acid 4-hydroxylase activity | Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid. |
| interleukin-1 type ii receptor antagonist activity | Blocks the binding of interleukin-1 to interleukin-1 Type II receptors. |
| beta-amyloid binding | Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor. |
| secondary active monocarboxylate transmembrane transporter activity | Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism. |
| alpha-catenin binding | Interacting selectively and non-covalently with the alpha subunit of the catenin complex. |
| cyclase inhibitor activity | Decreases the activity of an enzyme that catalyzes a ring closure reaction. |
| l-dopa decarboxylase activator activity | Interacts with and increases L-dopa decarboxylase activity. |
| riboflavin reductase (nadph) activity | Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+. |
| inorganic anion exchanger activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out). |
| thyroid-stimulating hormone receptor activity | Combining with thyroid-stimulating hormone to initiate a change in cell activity. |
| oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
| protein heterodimerization activity | Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. |
| l-phenylalanine:2-oxoglutarate aminotransferase activity | Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate. |
| single-stranded dna 3'-5' exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule. |
| polyprenyldihydroxybenzoate methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + 3-polyprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-polyprenyl-4-hydroxy-5-methoxybenzoate + H+. |
| retinoid binding | Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. |
| raffinose alpha-galactosidase activity | Catalysis of the reaction: raffinose + H2O = alpha-D-galactose + sucrose. |
| signaling pattern recognition receptor activity | Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity. |
| camp-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP. |
| voltage-gated potassium channel activity involved in sa node cell action potential repolarization | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| temperature-gated ion channel activity | Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism). |
| beta-galactosidase activity | Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. |
| pantothenate kinase activity | Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate. |
| aspartoacylase activity | Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate. |
| branched-chain amino acid transmembrane transporter activity | Catalysis of the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. |
| lathosterol oxidase activity | Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol + O2 = cholesta-5,7-dien-3-beta-ol + H2O2. |
| histone kinase activity (h3-s10 specific) | Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3. |
| wide pore channel activity | Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts. |
| glutamate receptor activity | Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity | Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O(2) = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(2)O + NADP(+). |
| n-acetyltransferase activity | Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. |
| pyrimidine nucleotide-sugar transmembrane transporter activity | Catalysis of the transfer of a pyrimidine nucleotide-sugar from one side of the membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. |
| hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. |
| acylglycerol kinase activity | Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate. |
| g-protein coupled neurotensin receptor activity | Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. |
| fmn adenylyltransferase activity | Catalysis of the reaction: ATP + FMN = diphosphate + FAD. |
| threonine synthase activity | Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate. |
| cyclin-dependent protein kinase 5 activator activity | Increases the activity of cyclin-dependent protein kinase 5. |
| peptidyl-prolyl cis-trans isomerase activity | Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). |
| gbd domain binding | Interacting selectively and non-covalently with the GTPase protein binding domain (GDB) domain of a protein. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac. |
| phosphatase activity | Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. |
| inositol hexakisphosphate 5-kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate. |
| phosphatidylinositol phosphate 5-phosphatase activity | Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate. |
| l-cysteine desulfhydrase activity | Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+. |
| transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity | A TGF-beta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators. |
| low-affinity sodium:dicarboxylate symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. |
| d2 dopamine receptor binding | Interacting selectively and non-covalently with a D2 dopamine receptor. |
| tfiib-class transcription factor binding | Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor. |
| high-affinity lysine transmembrane transporter activity | Catalysis of the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. |
| sulfur compound transmembrane transporter activity | Catalysis of the transfer of a sulfur compound from one side of the membrane to the other. |
| endodeoxyribonuclease activity, producing 3'-phosphomonoesters | Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters. |
| dna translocase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule. |
| phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. |
| oxidoreductase activity, acting on iron-sulfur proteins as donors | Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
| alpha-n-acetylneuraminate alpha-2,8-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R. |
| double-stranded rna-specific ribonuclease activity | Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules. |
| l-asparagine transmembrane transporter activity | Catalysis of the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid. |
| mannosyl-oligosaccharide glucosidase activity | Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2). |
| protein phosphatase 2a binding | Interacting selectively and non-covalently with the enzyme protein phosphatase 2A. |
| choloyl-coa hydrolase activity | Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA. |
| glycosaminoglycan binding | Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues. |
| sterol transporter activity | Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
| hydrogen:amino acid symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in). |
| o-acetyltransferase activity | Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule. |
| voltage-gated sodium channel activity involved in cardiac muscle cell action potential | Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| sodium:amino acid symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). |
| fc-gamma receptor i complex binding | Interacting selectively and non-covalently with one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG. |
| succinate dehydrogenase (ubiquinone) activity | Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol. |
| core promoter binding | Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. |
| aldehyde dehydrogenase (nad) activity | Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. |
| gap junction hemi-channel activity | A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction. |
| eukaryotic initiation factor 4g binding | Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation. |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. |
| prostaglandin-endoperoxide synthase activity | Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. |
| glycosylceramidase activity | Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine. |
| thioesterase binding | Interacting selectively and non-covalently with any thioesterase enzyme. |
| mutlbeta complex binding | Interacting selectively and non-covalently with the mismatch repair complex MutLbeta. |
| opsonin binding | Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material. |
| gap junction channel activity | A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. |
| enterobactin transporter activity | Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells. |
| dipeptide transporter activity | Enables the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells. |
| phospholipid binding | Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. |
| d1 dopamine receptor binding | Interacting selectively and non-covalently with a D1 dopamine receptor. |
| ethanolamine kinase activity | Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine. |
| transcription factor binding | Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. |
| carbon-nitrogen ligase activity, with glutamine as amido-n-donor | Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. |
| phospholipase inhibitor activity | Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. |
| rna stem-loop binding | Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop. |
| interleukin-23 receptor activity | Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| gpi-linked ephrin receptor activity | Combining with a GPI-anchored ephrin to initiate a change in cell activity. |
| glutamine-fructose-6-phosphate transaminase (isomerizing) activity | Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. |
| proton-transporting atp synthase activity, rotational mechanism | Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism. |
| snap receptor activity | Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. |
| fatty-acyl-coa synthase activity | Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+. |
| core promoter proximal region dna binding | Interacting selectively and non-covalently with a region of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon. |
| udp-glucose 6-dehydrogenase activity | Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate. |
| guanyl nucleotide binding | Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. |
| l-tyrosine transmembrane transporter activity | Catalysis of the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid. |
| n-acetylgalactosamine 4-sulfate 6-o-sulfotransferase activity | Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate. |
| histone demethylase activity (h3-r2 specific) | Catalysis of the removal of a methyl group from arginine at position 2 of the histone H3 protein. |
| protein phosphatase type 1 activator activity | Increases the activity of the enzyme protein phosphatase type 1. |
| atp:adp antiporter activity | Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out). |
| rs domain binding | Interacting selectively and non-covalently with an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing. |
| sarcosine oxidase activity | Catalysis of the reaction: H(2)O + O(2) + sarcosine = formaldehyde + glycine + H(2)O(2). |
| 14-3-3 protein binding | Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. |
| aryl hydrocarbon receptor binding | Interacting selectively and non-covalently with an aryl hydrocarbon receptor. |
| potassium:chloride symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in). |
| caax-protein geranylgeranyltransferase activity | Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. |
| inhibitory extracellular ligand-gated ion channel activity | Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels. |
| v1b vasopressin receptor binding | Interacting selectively and non-covalently with a V1B vasopressin receptor. |
| l-alanine transmembrane transporter activity | Catalysis of the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid. |
| n-acylmannosamine kinase activity | Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate. |
| dopamine:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) = dopamine(in) + Na+(in). |
| protein-dna loading atpase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the assembly of a protein or protein complex onto a DNA molecule. |
| cupric ion binding | Interacting selectively and non-covalently with cupric ion, copper(2+). |
| acylphosphatase activity | Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate. |
| 1-phosphatidylinositol-3-phosphate 5-kinase activity | Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+). |
| amino acid transmembrane transporter activity | Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. |
| carboxylic acid binding | Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). |
| delta14-sterol reductase activity | Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol. |
| nadph-adrenodoxin reductase activity | Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+. |
| rdna binding | Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA. |
| bisphosphoglycerate 3-phosphatase activity | Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phospho-D-glycerate + phosphate. |
| phosphatidylinositol phosphate 4-phosphatase activity | Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate. |
| o-methyltransferase activity | Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. |
| tumor necrosis factor-activated receptor activity | Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function. |
| interferon binding | Interacting selectively and non-covalently with an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent. |
| prostaglandin transmembrane transporter activity | Catalysis of the transfer of prostaglandins from one side of the membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. |
| methylarsonite methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate. |
| glycerol-3-phosphate dehydrogenase activity | Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. |
| 3-demethylubiquinone-n 3-o-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n. |
| transcription termination site sequence-specific dna binding | Interacting selectively and non-covalently with a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon. |
| rrna primary transcript binding | Interacting selectively and non-covalently with an unprocessed ribosomal RNA transcript. |
| mitogen-activated protein kinase kinase kinase binding | Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase. |
| tachykinin receptor activity | Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein. |
| cysteine transmembrane transporter activity | Catalysis of the transfer of cysteine from one side of the membrane to the other. |
| proline dehydrogenase activity | Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor. |
| linoleate 13s-lipoxygenase activity | Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. |
| asparagine-trna ligase activity | Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+). |
| sedoheptulokinase activity | Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H(+) + sedoheptulose 7-phosphate. |
| dna/rna helicase activity | Catalysis of the reaction: NTP + H2O = NDP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA. |
| glutamate-trna ligase activity | Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). |
| syntaxin-1 binding | Interacting selectively and non-covalently with the SNAP receptor syntaxin-1. |
| n-acylneuraminate cytidylyltransferase activity | Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate. |
| sodium:dicarboxylate symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). |
| taurochenodeoxycholate 6alpha-hydroxylase activity | Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O. |
| tripeptidase activity | Catalysis of the hydrolysis of a tripeptide. |
| deoxynucleotide transmembrane transporter activity | Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP. |
| placental growth factor-activated receptor activity | Combining with placental growth factor (PlGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| cysteine-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| spermidine synthase activity | Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine. |
| trna guanylyltransferase activity | Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs. |
| [acetyl-coa carboxylase] kinase activity | Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate. |
| tubulin-tyrosine ligase activity | Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate. |
| glycogen synthase activity, transferring glucose-1-phosphate | Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate. |
| 2-acylglycerol o-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol. |
| e-box binding | Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. |
| mrna (nucleoside-2'-o-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine. |
| 3-galactosyl-n-acetylglucosaminide 4-alpha-l-fucosyltransferase activity | Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R. |
| calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell. |
| sphingosine n-acyltransferase activity | Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine. |
| pituitary adenylate cyclase activating polypeptide activity | The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation. |
| fructose transmembrane transporter activity | Catalysis of the transfer of fructose from one side of the membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. |
| type 1 hypocretin receptor binding | Interacting selectively and non-covalently with a type 1 hypocretin receptor. |
| oxidoreductase activity, acting on ch or ch2 groups, quinone or similar compound as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule. |
| phosphatidylglycerol binding | Interacting selectively and non-covalently with phosphatidylglycerol. |
| prenyltransferase activity | Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). |
| alanine transmembrane transporter activity | Catalysis of the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid. |
| ceramide kinase activity | Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate. |
| tryptophan 2,3-dioxygenase activity | Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine. |
| cgmp-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP. |
| myosin binding | Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. |
| ligase activity, forming carbon-carbon bonds | Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| nad(p)+ transhydrogenase (ab-specific) activity | Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+. |
| macromolecule transmembrane transporter activity | Catalysis of the transfer of a macromolecule from one side of the membrane to the other. |
| interleukin-2 receptor binding | Interacting selectively and non-covalently with the interleukin-2 receptor. |
| peptide antigen binding | Interacting selectively and non-covalently with an antigen peptide. |
| corticotropin-releasing hormone receptor binding | Interacting selectively and non-covalently with a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland. |
| triphosphoric monoester hydrolase activity | Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group. |
| smoothened binding | Interacting selectively and non-covalently with the smoothened (smo) protein, which interacts with patched to transmit hedgehog signals. |
| angiotensin receptor binding | Interacting selectively and non-covalently with an angiotensin receptor. |
| calcium-dependent phospholipase a2 activity | Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+. |
| type 2 angiotensin receptor binding | Interacting selectively and non-covalently with a type 2 angiotensin receptor. |
| bradykinin receptor activity | Combining with bradykinin to initiate a change in cell activity. |
| fatty acid derivative binding | Interacting selectively and non-covalently with fatty acid derivative. |
| atp-dependent rna helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix. |
| voltage-gated sodium channel activity | Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| alkylglycerophosphoethanolamine phosphodiesterase activity | Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate. |
| nucleic acid binding transcription factor activity | Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. |
| sphingomyelin phosphodiesterase d activity | Catalysis of the reaction: H(2)O + sphingomyelin = ceramide 1-phosphate + choline + H(+). |
| agmatinase activity | Catalysis of the reaction: agmatine + H(2)O = putrescine + urea. |
| phosphotransferase activity, phosphate group as acceptor | Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). |
| retinoic acid-responsive element binding | Interacting selectively and non-covalently with a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind. |
| ubiquitin protein ligase binding | Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. |
| antiporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). |
| calmodulin-lysine n-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine. |
| high-affinity sodium:dicarboxylate symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. |
| rab guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
| inositol monophosphate 1-phosphatase activity | Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. |
| tripeptidyl-peptidase activity | Catalysis of the release of an N-terminal tripeptide from a polypeptide. |
| alanine-glyoxylate transaminase activity | Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine. |
| deoxycytidine kinase activity | Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP. |
| lipoprotein particle receptor activity | Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. |
| ribosome binding | Interacting selectively and non-covalently with any part of a ribosome. |
| aliphatic-amine oxidase activity | Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+. |
| aminoacyl-trna editing activity | The hydrolysis of an incorrectly aminoacylated tRNA. |
| calcitriol receptor activity | Combining with calcitriol, the hormonally active form of vitamin D3, and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. |
| type 2 hypocretin receptor binding | Interacting selectively and non-covalently with a type 2 hypocretin receptor. |
| glutamate-ammonia ligase activity | Catalysis of the reaction: L-glutamate + ATP + NH(4)(+) = L-glutamine + ADP + 2 H(+) + phosphate. |
| 2'-phosphotransferase activity | Catalysis of the transfer of a phosphate group from one compound to the 2' position of another. |
| purine ribonucleoside binding | Interacting selectively and non-covalently with a purine ribonucleoside, a compound consisting of a purine base linked to ribose. |
| 4-hydroxy-2-oxoglutarate aldolase activity | Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. |
| amidinotransferase activity | Catalysis of the reversible transfer of an amidino group to an acceptor. |
| high voltage-gated calcium channel activity | Catalysis of the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. |
| l-glutamate transmembrane transporter activity | Catalysis of the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid. |
| heparan sulfate proteoglycan binding | Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit. |
| rna polymerase iii activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| epidermal growth factor binding | Interacting selectively and non-covalently with epidermal growth factor. |
| glycoprotein-n-acetylgalactosamine 3-beta-galactosyltransferase activity | Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan. |
| glycine hydroxymethyltransferase activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. |
| semaphorin receptor binding | Interacting selectively and non-covalently with semaphorin receptors. |
| ferredoxin-nadp+ reductase activity | |
| alpha-2b adrenergic receptor binding | Interacting selectively and non-covalently with an alpha-2B adrenergic receptor. |
| estrogen receptor binding | Interacting selectively and non-covalently with an estrogen receptor. |
| exo-alpha-(2->8)-sialidase activity | Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates. |
| nacht domain binding | Interacting selectively and non-covalently with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs. |
| aminomethyltransferase activity | Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein. |
| deoxyribonucleoside 5'-monophosphate n-glycosidase activity | Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base. |
| gtpase activating protein binding | Interacting selectively and non-covalently with a GTPase activating protein. |
| l-lysine transmembrane transporter activity | Catalysis of the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid. |
| long-chain-enoyl-coa hydratase activity | Catalysis of the reaction: a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O. A long-chain acyl-CoA is an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms. |
| trail binding | Interacting selectively and non-covalently with TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines. |
| guanine deaminase activity | Catalysis of the reaction: guanine + H2O = xanthine + NH3. |
| somatostatin receptor binding | Interacting selectively and non-covalently with a somatostatin receptor. |
| sepiapterin reductase activity | Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+. |
| euchromatin binding | Interacting selectively and non-covalently with euchromatin, a dispersed and relatively uncompacted form of chromatin. |
| fructose-bisphosphate aldolase activity | Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate. |
| beta-n-acetylglucosaminidase activity | Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides. |
| identical protein binding | Interacting selectively and non-covalently with an identical protein or proteins. |
| sequence-specific dna binding transcription factor activity | Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. |
| channel activity | Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules. |
| xanthine oxidase activity | Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide. |
| l-pipecolate oxidase activity | Catalysis of the reaction: L-pipecolate + O(2) = 2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2) + H(+). Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate. |
| methylmalonyl-coa epimerase activity | Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA. |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines | Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. |
| single thymine insertion binding | Interacting selectively and non-covalently with double-stranded DNA containing a single thymine insertion or a deletion that results in an unpaired thymine. |
| chromatin insulator sequence binding | Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription. |
| bile acid-exporting atpase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O -> bile acid(out) + ADP + phosphate. |
| trna (guanine-n2-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine. |
| protein transporter activity | Enables the directed movement of proteins into, out of or within a cell, or between cells. |
| endogenous lipid antigen binding | Interacting selectively and non-covalently with an endogenous cellular lipid antigen. |
| mu-type opioid receptor binding | Interacting selectively and non-covalently with a mu-type opioid receptor. |
| tyrosine 3-monooxygenase activator activity | Interacts with and increases tyrosine 3-monooxygenase (tyrosine hydroxylase) activity. |
| phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. |
| dopamine beta-monooxygenase activity | Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O. |
| rna polymerase iii core binding | Interacting selectively and non-covalently with RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits. |
| nociceptin receptor activity | Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein. |
| collagen binding involved in cell-matrix adhesion | Any collagen binding that occurs as part of cell-matrix adhesion. |
| carbon-sulfur lyase activity | Catalysis of the elimination of hydrogen sulfide or substituted H2S. |
| inositol tetrakisphosphate phosphatase activity | Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate. |
| methylcrotonoyl-coa carboxylase activity | Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate. |
| acyl-coa dehydrogenase activity | Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. |
| actin filament binding | Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| platelet activating factor receptor activity | Combining with platelet activating factor to initiate a change in cell activity. |
| pyroglutamyl-peptidase activity | Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein. |
| ribonuclease p activity | Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. |
| aminopeptidase activity | Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. |
| lipoprotein transporter activity | Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells. |
| glycolipid binding | Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. |
| histone kinase activity (h3-y41 specific) | The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone. |
| histone methyltransferase activity (h3-k79 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group onto lysine at position 79 of the histone H3 protein. |
| platelet-derived growth factor alpha-receptor activity | Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity. |
| transaminase activity | Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. |
| extracellular matrix structural constituent conferring tensile strength | A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress. |
| mitogen-activated protein kinase binding | Interacting selectively and non-covalently with a mitogen-activated protein kinase. |
| type 1 galanin receptor binding | Interacting selectively and non-covalently with a type 1 galanin receptor. |
| 3-keto sterol reductase activity | Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+). |
| dna-dependent atpase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction. |
| dolichyl-phosphate beta-glucosyltransferase activity | Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate. |
| gtp-dependent protein binding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP. |
| inositol-1,4,5-trisphosphate 3-kinase activity | Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+). |
| ceramide 1-phosphate binding | Interacting selectively and non-covalently with ceramide 1-phosphate. |
| ligand-activated sequence-specific dna binding rna polymerase ii transcription factor activity | Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. |
| oxidoreductase activity, acting on the ch-nh2 group of donors, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. |
| l-glucuronate reductase activity | Catalysis of the reaction: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH. |
| prostaglandin d receptor activity | Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity. |
| antioxidant activity | Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. |
| s-succinyltransferase activity | Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule. |
| short-chain fatty acid uptake transporter activity | Enables the directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than C6. |
| rna polymerase ii transcription cofactor activity | Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery. |
| phosphatidylcholine transporter activity | Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. |
| tubulin n-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine. |
| neurotrophin trka receptor binding | Interacting selectively and non-covalently with the neurotrophin TRKA receptor. |
| virus receptor activity | Combining with a virus component and mediating entry of the virus into the cell. |
| ufm1 hydrolase activity | Catalysis of the hydrolysis of UFM1, a small ubiquitin-related modifier, from previously modified substrates. |
| anion:cation symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in). |
| metallopeptidase activity | Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| calcium channel regulator activity | Modulates the activity of a calcium channel. |
| suramin binding | Interacting selectively and non-covalently with suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms. |
| udp-glucuronate decarboxylase activity | Catalysis of the reaction: H(+) + UDP-alpha-D-glucuronate = CO(2) + UDP-alpha-D-xylose. |
| cob(i)yrinic acid a,c-diamide adenosyltransferase activity | Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin. |
| dihydronicotinamide riboside quinone reductase activity | Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone. |
| histone demethylase activity (h4-r3 specific) | Catalysis of the removal of a methyl group from arginine at position 3 of the histone H4 protein. |
| exo-alpha-sialidase activity | Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. |
| lipase binding | Interacting selectively and non-covalently with any lipase. |
| alkenylglycerophosphoethanolamine hydrolase activity | Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde. |
| trna (uracil) methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule. |
| diphosphoric monoester hydrolase activity | Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group. |
| androgen binding | Interacting selectively and non-covalently with any androgen, male sex hormones. |
| dna (cytosine-5-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. |
| transferase activity, transferring alkylthio groups | Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor). |
| igm binding | Interacting selectively and non-covalently with an immunoglobulin of the IgM isotype. |
| nucleoside-triphosphate diphosphatase activity | Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide. |
| succinate-coa ligase activity | Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA. |
| dna-3-methylguanine glycosylase activity | Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site. |
| l-lactate dehydrogenase activity | Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. |
| glycerophosphocholine phosphodiesterase activity | Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline. |
| quaternary ammonium group transmembrane transporter activity | Catalysis of the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. |
| oxidoreductase activity, acting on diphenols and related substances as donors | Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
| c4-dicarboxylate transmembrane transporter activity | Catalysis of the transfer of C4-dicarboxylate from one side of the membrane to the other. |
| nucleoside-diphosphatase activity | Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate. |
| rna ligase (atp) activity | Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m). |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. |
| transmembrane receptor protein serine/threonine kinase binding | Interacting selectively and non-covalently with a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity. |
| glutathione disulfide oxidoreductase activity | Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor. |
| chromo shadow domain binding | Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain. |
| deacetylase activity | Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. |
| succinate-semialdehyde dehydrogenase (nad+) activity | Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+. |
| racemase and epimerase activity | Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. |
| muscle alpha-actinin binding | Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc. |
| outward rectifier potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force. |
| cholesterol binding | Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
| 3'-5' rna helicase activity | Catalysis of the unwinding of an RNA helix in the direction 3' to 5'. |
| nad(p)h dehydrogenase (quinone) activity | |
| peptidoglycan binding | Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. |
| glutamate formimidoyltransferase activity | Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate. |
| histone methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue. |
| guanidinoacetate n-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H(+). |
| box c/d snorna binding | Interacting selectively and non-covalently with box C/D small nucleolar RNA. |
| oxidoreductase activity, acting on the ch-ch group of donors, with a flavin as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin. |
| lithocholic acid receptor activity | Combining with lithocholic acid and transmitting the signal to initiate a change in cell activity. |
| sphinganine kinase activity | Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate. |
| pituitary adenylate cyclase-activating polypeptide receptor binding | Interacting selectively and non-covalently with a pituitary adenylate cyclase-activating polypeptide receptor. |
| chondroitin 4-sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate. |
| phosphoribosylformylglycinamidine cyclo-ligase activity | Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate. |
| alpha-n-acetylgalactosaminidase activity | Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides. |
| small gtpase binding | Interacting selectively and non-covalently with a small monomeric GTPase. |
| protein tag | Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question. |
| corticotropin-releasing hormone activity | The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary. |
| kappa-type opioid receptor binding | Interacting selectively and non-covalently with a kappa-type opioid receptor. |
| estrogen receptor activity | Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function. |
| oligopeptide binding | Interacting selectively and non-covalently with an oligopeptide. |
| n6-(1,2-dicarboxyethyl)amp amp-lyase (fumarate-forming) activity | Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. |
| enkephalin receptor activity | Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body. |
| oxo-acid-lyase activity | Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. |
| l-glutamine aminotransferase activity | Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid. |
| glucose binding | Interacting selectively and non-covalently with the D- or L-enantiomer of glucose. |
| acylglycerol o-acyltransferase activity | Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. |
| cobalamin binding | Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. |
| demethylase activity | Catalysis of the removal of a methyl group from a substrate. |
| nad(p)h oxidase activity | Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide. |
| acetyltransferase activator activity | Increases the activity of an aceyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule. |
| type 1 angiotensin receptor binding | Interacting selectively and non-covalently with a type 1 angiotensin receptor. |
| tau-protein kinase activity | Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. |
| mhc class ii protein binding | Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. |
| zinc transporting atpase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in). |
| s-acetyltransferase activity | Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule. |
| phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. |
| icosanoid binding | Interacting selectively and non-covalently with icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids. |
| endoribonuclease activity, producing 3'-phosphomonoesters | Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters. |
| methylumbelliferyl-acetate deacetylase activity | Catalysis of the reaction: 4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate + H(+). |
| glycylpeptide n-tetradecanoyltransferase activity | Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide. |
| (n-acetylneuraminyl)-galactosylglucosylceramide n-acetylgalactosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide. |
| spermine synthase activity | Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine. |
| leucine zipper domain binding | Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. |
| glyoxylate oxidase activity | Catalysis of the reaction: glyoxylate + H(2)O + O(2) = H(2)O(2) + H(+) + oxalate. |
| atg12 transferase activity | Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y --> Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages. |
| linoleic acid binding | Interacting selectively and non-covalently with linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid. |
| carboxylic ester hydrolase activity | Catalysis of the hydrolysis of a carboxylic ester bond. |
| o-acyltransferase activity | Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. |
| atp citrate synthase activity | Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA. |
| acid-amino acid ligase activity | Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| substance p receptor activity | Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity. |
| cation channel activity | Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. |
| acyl binding | Interacting selectively and non-covalently with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid. |
| itp binding | Interacting selectively and non-covalently with ITP. |
| phosphoglycolate phosphatase activity | Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate. |
| steroid hydroxylase activity | Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. |
| glucosamine-6-phosphate deaminase activity | Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+). |
| n-acetylgalactosamine-6-sulfatase activity | Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate. |
| glutamine-trna ligase activity | Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). |
| diphosphoinositol-pentakisphosphate kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate. |
| rho guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
| phosphoglycerate dehydrogenase activity | Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. |
| ras gtpase binding | Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases. |
| rna polymerase ii sequence-specific dna binding transcription factor binding | Interacting selectively and non-covalently with a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. |
| gamma-catenin binding | Interacting selectively and non-covalently with the gamma subunit of the catenin complex. |
| nad+ diphosphatase activity | Catalysis of the reaction: NAD+ + H2O = AMP + NMN. |
| mast cell secretagogue receptor activity | |
| arachidonate 8(s)-lipoxygenase activity | Catalysis of the reaction: arachidonate + O(2) = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate. |
| 25-hydroxycholecalciferol-24-hydroxylase activity | Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol. |
| adp-ribose diphosphatase activity | Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate. |
| amine transmembrane transporter activity | Catalysis of the transfer of amines, including polyamines, from one side of the membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. |
| telethonin binding | Interacting selectively and non-covalently with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase. |
| potassium ion leak channel activity | Catalysis of the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state. |
| open rectifier potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration. |
| gdp-4-dehydro-d-rhamnose reductase activity | Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed. |
| oxytocin receptor binding | Interacting selectively and non-covalently with an oxytocin receptor. |
| x11-like protein binding | Interacting selectively and non-covalently with X11-like protein, a neuron-specific adaptor protein. |
| rna polymerase i core element sequence-specific dna binding transcription factor recruiting transcription factor activity | Interacting selectively and non-covalently with the CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery and also binding to an RNA polymerase I (RNAP I) transcription factor to recruit it to the transcription machinery complex in order to modulate transcription by RNA polymerase I. |
| rhodopsin kinase activity | Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin. |
| secondary active transmembrane transporter activity | Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Chemiosmotic sources of energy include uniport, symport or antiport. |
| protein kinase c inhibitor activity | Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein. |
| leukotriene-b4 20-monooxygenase activity | Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O. |
| sh3 domain binding | Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. |
| l-dopa receptor activity | Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine. |
| poz domain binding | Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors. |
| transcription factor binding transcription factor activity | Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. |
| exopeptidase activity | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. |
| prostaglandin-e2 9-reductase activity | Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH. |
| c3a anaphylatoxin receptor activity | Combining with anaphylatoxin C3a to initiate a change in cell activity. |
| primary mirna binding | Interacting selectively and non-covalently with a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding. |
| ctp:3'-cytidine-trna cytidylyltransferase activity | Catalysis of the reaction: a tRNA with a 3' cytidine + CTP = a tRNA with a 3' CC end + diphosphate. |
| translation regulator activity | Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. |
| cdp-diacylglycerol-serine o-phosphatidyltransferase activity | Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine. |
| calcium-dependent phospholipid binding | Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. |
| mutsbeta complex binding | Interacting selectively and non-covalently with the mismatch repair complex MutSbeta. |
| s-(hydroxymethyl)glutathione dehydrogenase activity | Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+. |
| calcium-independent phospholipase a2 activity | Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+. |
| bisphosphoglycerate mutase activity | Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate. |
| double-stranded dna exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule. |
| inositol pentakisphosphate phosphatase activity | Catalysis of the reaction: myo-inositol pentakisphosphate + H2O = myo-inositol tetrakisphosphate + phosphate. |
| ion channel binding | Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. |
| dna helicase activity | Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix. |
| activating mhc class i receptor activity | Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte. |
| rna polymerase i core element sequence-specific dna binding transcription factor activity | Interacting selectively and non-covalently with CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery in order to modulate transcription by RNA polymerase I. |
| u6 snrna binding | Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA). |
| phenylpyruvate tautomerase activity | Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate. |
| adp binding | Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate. |
| potassium ion binding | Interacting selectively and non-covalently with potassium (K+) ions. |
| copper ion transmembrane transporter activity | Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. |
| interleukin-13 receptor binding | Interacting selectively and non-covalently with the interleukin-13 receptor. |
| dopamine neurotransmitter receptor activity, coupled via gs | Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity. |
| death receptor activity | Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death. |
| oxidoreductase activity, acting on peroxide as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. |
| glucagon receptor activity | Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| androgen receptor activity | Combining with an androgen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an androgen response element in DNA in order to modulate transcription by RNA polymerase II. |
| rna-directed dna polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. |
| all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity | Catalysis of the reaction: H(2)O + all-trans-retinyl palmitate = 11-cis-retinol + H(+) + palmitate. |
| magnesium-dependent protein serine/threonine phosphatase activity | Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of magnesium. |
| high-density lipoprotein particle receptor binding | Interacting selectively and non-covalently with a high-density lipoprotein receptor. |
| glucose transmembrane transporter activity | Catalysis of the transfer of the hexose monosaccharide glucose from one side of the membrane to the other. |
| inositol-1,3,4-trisphosphate 6-kinase activity | Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+). |
| nedd8 transferase activity | Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages. |
| formimidoyltetrahydrofolate cyclodeaminase activity | Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH(4)(+). |
| adenosine deaminase activity | Catalysis of the reaction: adenosine + H2O = inosine + NH3. |
| receptor signaling protein tyrosine phosphatase activity | Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| dna hairpin binding | Interacting selectively and non-covalently with DNA containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences. |
| chenodeoxycholic acid binding | Interacting selectively and non-covalently with chenodeoxycholic acid. |
| inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity | Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. |
| ribonuclease p rna binding | Interacting selectively and non-covalently with the RNA subunit of ribonuclease P. |
| protein-glutamine n-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine. |
| nicotinate transporter activity | Enables the directed movement of nicotinate into, out of or within a cell, or between cells. |
| pyrimidine nucleotide binding | Interacting selectively and non-covalently with pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor. |
| cyclohydrolase activity | Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring. |
| glycine n-acyltransferase activity | Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine. |
| neuromedin u binding | Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses. |
| interleukin-17e receptor binding | Interacting selectively and non-covalently with the interleukin-17E receptor. |
| bubble dna binding | Interacting selectively and non-covalently with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA. |
| cholesterol 26-hydroxylase activity | Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol. |
| oxidoreductase activity, acting on the ch-oh group of donors, quinone or similar compound as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. |
| leukemia inhibitory factor receptor activity | Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| creatine kinase activity | Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). |
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
| long-chain acyl-coa hydrolase activity | Catalysis of the reaction: H2O + a long-chain acyl-CoA = a long-chain carboxylate + CoA. A long chain is a chain of greater than 12 carbons in length. |
| transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity | A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription. |
| calcium-dependent protein serine/threonine phosphatase activity | Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions. |
| oxidoreductase activity, acting on the aldehyde or oxo group of donors | Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
| 7s rna binding | Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). |
| oxalate transmembrane transporter activity | Catalysis of the transfer of oxalate from one side of the membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. |
| oxidoreductase activity, acting on the ch-nh2 group of donors, nad or nadp as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
| fatty-acyl-coa binding | Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. |
| n-acetylglucosamine-1-phosphodiester alpha-n-acetylglucosaminidase activity | Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose. |
| udp-n-acetylglucosamine-dolichyl-phosphate n-acetylglucosaminephosphotransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol. |
| aromatase activity | Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. |
| phosphoric ester hydrolase activity | Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. |
| glycerophosphocholine cholinephosphodiesterase activity | Catalysis of the reaction: sn-glycero-3-phosphocholine + H(2)O = choline phosphate + glycerol + H(+). |
| alkenylglycerophosphocholine hydrolase activity | Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde. |
| ffat motif binding | Interacting selectively and non-covalently with the FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family. |
| nucleoside:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in). |
| transmembrane signaling receptor activity | Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| 17-alpha-hydroxyprogesterone aldolase activity | Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione. |
| 1-pyrroline-5-carboxylate dehydrogenase activity | Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+). |
| l-histidine transmembrane transporter activity | Catalysis of the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. |
| beta-1,4-mannosyltransferase activity | Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage. |
| platelet-activating factor acetyltransferase activity | Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid. |
| transcription corepressor activity | Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery. |
| map kinase kinase kinase activity | Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. |
| trna binding | Interacting selectively and non-covalently with transfer RNA. |
| peroxisome proliferator activated receptor binding | Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma. |
| inositol-1,4,5-trisphosphate 6-kinase activity | Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H(+). |
| glutamate-trna(gln) ligase activity | Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP. |
| enhancer binding | Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter. |
| er retention sequence binding | Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. |
| atp-activated nucleotide receptor activity | Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by ATP. |
| sterol binding | Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. |
| protein binding involved in cell-cell adhesion | Any protein binding that is involved in cell-cell adhesion. |
| nadphx epimerase activity | Catalysis of the reaction: (R)-NADPHX = (S)-NADPHX. |
| nicotinate-nucleotide adenylyltransferase activity | Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+. |
| hsp70 protein binding | Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size. |
| bile acid transmembrane transporter activity | Catalysis of the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. |
| 1-phosphatidylinositol-4-phosphate 5-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+). |
| polyubiquitin binding | Interacting selectively and non-covalently with a polymer of ubiqutin. |
| protein-glycine ligase activity, initiating | Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein. |
| neuropeptide hormone activity | The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. |
| extracellular matrix structural constituent conferring compression resistance | A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan. |
| myosin tail binding | Interacting selectively and non-covalently with the tail region of a myosin heavy chain. |
| l-phenylalanine:pyruvate aminotransferase activity | Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine. |
| granulocyte colony-stimulating factor receptor binding | Interacting selectively and non-covalently with the granulocyte colony-stimulating factor receptor. |
| cardiolipin hydrolase activity | Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol) to form phosphatidic acid (PA). |
| pyruvate kinase activity | Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. |
| atpase activity, coupled | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane. |
| signaling receptor activity | Receiving a signal and transmitting the signal in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. |
| 3-hydroxyacyl-coa dehydrogenase activity | Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+). |
| tocopherol omega-hydroxylase activity | Catalysis of the reaction: tocopherol + O2 + NADPH + H+ = 13'-hydroxy-tocopherol + NADP+ + H2O . |
| cytokine binding | Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. |
| trans-2-enoyl-coa reductase (nadph) activity | Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+. |
| heparin binding | Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. |
| metalloenzyme activator activity | Increases the activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal. |
| gtpase activator activity | Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| fructose-1-phosphate aldolase activity | Catalysis of the reaction: D-fructose-1-phosphate = dihydroxyacetone phosphate + D-glyceraldehyde. |
| octanoyltransferase activity | Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule. |
| protein binding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
| c-8 sterol isomerase activity | Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols. |
| gdp-mannose 4,6-dehydratase activity | Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O. |
| growth hormone-releasing hormone receptor activity | Combining with growth hormone-releasing hormone to initiate a change in cell activity. |
| delayed rectifier potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and activation is slow. |
| receptor serine/threonine kinase binding | Interacting selectively and non-covalently with a receptor that possesses protein serine/threonine kinase activity. |
| protein serine/threonine kinase inhibitor activity | Stops, prevents or reduces the activity of a protein serine/threonine kinase. |
| methylated histone binding | Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. |
| granulocyte macrophage colony-stimulating factor receptor binding | Interacting selectively and non-covalently with the granulocyte macrophage colony-stimulating factor receptor. |
| low-density lipoprotein particle binding | Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. |
| complement binding | Interacting selectively and non-covalently with any component or product of the complement cascade. |
| isomerase activity | Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. |
| protein-lysine n-methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. |
| histamine binding | Interacting selectively and non-covalently with histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. |
| l-malate dehydrogenase activity | Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. |
| 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity | Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. |
| tetracycline transporter activity | Enables the directed movement of tetracycline into, out of or within a cell, or between cells. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). |
| cholecystokinin receptor activity | Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone. |
| double-stranded rna binding | Interacting selectively and non-covalently with double-stranded RNA. |
| mrna 5'-utr binding | Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule. |
| transcription coactivator binding | Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. |
| map kinase phosphatase activity | Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate. |
| arachidonic acid omega-hydroxylase activity | Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid. |
| transcription regulatory region sequence-specific dna binding | Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
| dimethylargininase activity | Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline. |
| bile acid receptor activity | Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile. |
| ryanodine-sensitive calcium-release channel activity | Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. |
| porin activity | Catalysis of the transfer of substances, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. |
| adiponectin binding | Interacting selectively and non-covalently with adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism. |
| histone methyltransferase activity (h3-r2 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to arginine at position 2 of histone H3. |
| deoxycytidine deaminase activity | Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3. |
| amp deaminase activity | Catalysis of the reaction: AMP + H2O = IMP + NH3. |
| 6-pyruvoyltetrahydropterin synthase activity | Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate. |
| mitochondrial heavy strand promoter anti-sense binding | Interacting selectively and non-covalently with the anti-sense strand of the heavy strand promoter, a promoter located on the heavy, or guanine-rich, strand of mitochondrial DNA. |
| dna 5'-adenosine monophosphate hydrolase activity | Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus. |
| alpha,alpha-trehalase activity | Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose. |
| alpha-tubulin binding | Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin. |
| methionine adenosyltransferase activity | Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. |
| sulfate adenylyltransferase (atp) activity | Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate. |
| dna ligase (atp) activity | Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). |
| fructosamine-3-kinase activity | Catalysis of the phosphorylation of fructosamine to form fructosamine-3-kinase. |
| interleukin-7 binding | Interacting selectively and non-covalently with interleukin-7. |
| voltage-gated sodium channel activity involved in sa node cell action potential | Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| alpha-1,6-mannosyltransferase activity | Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage. |
| alcohol transmembrane transporter activity | Catalysis of the transfer of an alcohol from one side of the membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group. |
| rna polymerase ii core promoter sequence-specific dna binding transcription factor activity | Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. |
| glucosamine 6-phosphate n-acetyltransferase activity | Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+). |
| inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity | Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate. |
| linear polyubiquitin binding | Interacting selectively and non-covalently with a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next. |
| nucleotide transmembrane transporter activity | Catalysis of the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other. |
| double-strand/single-strand dna junction binding | Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA. |
| udp-galactosyltransferase activity | Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule. |
| exo-alpha-(2->6)-sialidase activity | Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates. |
| l-glutamine transmembrane transporter activity | Catalysis of the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid. |
| l-ascorbic acid binding | Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. |
| double-stranded telomeric dna binding | Interacting selectively and non-covalently with double-stranded telomere-associated DNA. |
| thyroid hormone receptor binding | Interacting selectively and non-covalently with a thyroid hormone receptor. |
| heparan-alpha-glucosaminide n-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide. |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| p-p-bond-hydrolysis-driven transmembrane transporter activity | Primary active transport of a solute across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. |
| cholestenone 5-alpha-reductase activity | Catalysis of the reaction: 5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH. |
| receptor signaling complex scaffold activity | Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex. |
| camp response element binding | Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP. |
| phosphatidylinositol kinase activity | Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. |
| solute:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in). |
| hla-a specific inhibitory mhc class i receptor activity | Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte. |
| l-aspartate:2-oxoglutarate aminotransferase activity | Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. |
| mitogen-activated protein kinase p38 binding | Interacting selectively and non-covalently with mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation. |
| adenylosuccinate synthase activity | Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate. |
| isopentenyl-diphosphate delta-isomerase activity | Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate. |
| 1-acylglycerophosphocholine o-acyltransferase activity | Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA. |
| peptide-serine-n-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + N-terminal L-serine in peptide = CoA + N-acetyl-L-serine-peptide. |
| complement component c3a receptor activity | Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| hmg box domain binding | Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. |
| gamma-tubulin binding | Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin. |
| pyridoxal kinase activity | Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. |
| amide transmembrane transporter activity | Enables the directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of the membrane to the other. |
| pyruvate dehydrogenase (acetyl-transferring) activity | Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. |
| udp-glucuronate 5'-epimerase activity | Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-L-iduronate. |
| calcium-activated potassium channel activity | Catalysis of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. |
| fatz binding | Interacting selectively and non-covalently with a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components. |
| datp binding | Interacting selectively and non-covalently with dATP, deoxyadenosine triphosphate. |
| oxidoreductase activity, acting on the ch-nh group of donors, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen. |
| phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity | Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate. |
| steroid dehydrogenase activity, acting on the ch-oh group of donors, nad or nadp as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative. |
| g-quadruplex rna binding | Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad. |
| prostaglandin-d synthase activity | Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2). |
| sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential | Catalysis of the transfer of a solute or solutes from one side of a cardiac muscle cell membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). This transfer contributes to the regulation of the cardiac muscle cell plasma membrane potential. |
| vitamin binding | Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. |
| l-threonine transmembrane transporter activity | Catalysis of the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid. |
| tbp-class protein binding | Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). |
| oligopeptidase activity | Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds. |
| alcohol dehydrogenase [nad(p)+] activity | |
| hepatocyte growth factor receptor binding | Interacting selectively and non-covalently with the hepatocyte growth factor receptor. |
| hyalurononglucosaminidase activity | Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. |
| annealing helicase activity | Catalysis of the ATP-dependent rewinding of single-stranded DNA (ssDNA) to reform base pairs between strands. Often acts on ssDNA bubbles bound by replication protein A (RPA). |
| atp binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| sulfur compound binding | Interacting selectively and non-covalently with a sulfur compound. |
| hydro-lyase activity | Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. |
| glycogen (starch) synthase activity | Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1). |
| kinase binding | Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
| protein-arginine n-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine. |
| dna binding, bending | The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. |
| neurokinin receptor binding | Interacting selectively and non-covalently with a neurokinin receptor. |
| l-valine transaminase activity | Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid. |
| aryl sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. |
| biotin-[propionyl-coa-carboxylase (atp-hydrolyzing)] ligase activity | Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming)). |
| complement component c1q binding | Interacting selectively and non-covalently with the C1q component of the classical complement cascade. |
| isg15 transferase activity | Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. |
| dipeptidyl-peptidase activity | Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. |
| beta-aspartyl-peptidase activity | Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide. |
| alpha-1,6-mannosylglycoprotein 2-beta-n-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R. |
| c-4 methylsterol oxidase activity | Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O. |
| urocanate hydratase activity | Catalysis of the reaction: 4-imidazolone-5-propanoate + H(+) = trans-urocanate + H(2)O. |
| peptidase regulator activity | Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. |
| (1->3)-beta-d-glucan binding | Interacting selectively and non-covalently with (1->3)-beta-D-glucans. |
| l-leucine transmembrane transporter activity | Catalysis of the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid. |
| brain-derived neurotrophic factor binding | Interacting selectively and non-covalently with brain-derived neurotrophic factor. |
| lysine n-methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. |
| peptidoglycan glycosyltransferase activity | Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate. |
| oxysterol 7-alpha-hydroxylase activity | Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O. |
| gdp-dissociation inhibitor activity | Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. |
| rho gdp-dissociation inhibitor activity | Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding. |
| histone methyltransferase activity (h3-r17 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to arginine at position 17 of histone H3. |
| sarcosine dehydrogenase activity | Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein. |
| gdp-man:man1glcnac2-pp-dol alpha-1,3-mannosyltransferase activity | Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage. |
| steroid sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate. |
| palmitoyl-(protein) hydrolase activity | Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. |
| inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity | Catalysis of the reaction: inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+. |
| ribonuclease t2 activity | Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. |
| phosphoprotein phosphatase activity | Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. |
| fatty acid amide hydrolase activity | Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid. |
| hemoglobin binding | Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. |
| protein serine/threonine kinase activator activity | Increases the activity of a protein serine/threonine kinase. |
| udp-glucuronic acid transmembrane transporter activity | Catalysis of the transfer of a UDP-glucuronic acid from one side of the membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. |
| calmodulin-dependent cyclic-nucleotide phosphodiesterase activity | Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin. |
| galanin receptor binding | Interacting selectively and non-covalently with a galanin receptor. |
| prostaglandin e receptor activity | Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. |
| vitamin e binding | Interacting selectively and non-covalently with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. |
| double-stranded rna adenosine deaminase activity | Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule. |
| rna polymerase ii regulatory region sequence-specific dna binding | Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
| calcium oxalate binding | Interacting selectively and non-covalently with calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi. |
| oleic acid binding | Interacting selectively and non-covalently with oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid. |
| rna polymerase ii core promoter proximal region sequence-specific dna binding transcription factor activity | Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II. |
| mhc class ib protein binding | Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules. |
| fatty acid synthase activity | Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. |
| extracellular-glycine-gated chloride channel activity | Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts. |
| diolein transacylation activity | Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein. |
| orexin receptor activity | Combining with orexin to initiate a change in cell activity. |
| purinergic receptor activity | Combining with a purine or purine derivative (purine nucleoside or purine nucleotide) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. |
| oxytocin receptor activity | Combining with oxytocin to initiate a change in cell activity. |
| dolichyl-diphosphooligosaccharide-protein glycotransferase activity | Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. |
| fatty acid elongase activity | Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C). |
| succinate-hydroxymethylglutarate coa-transferase activity | Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate. |
| 4-hydroxybenzoate decaprenyltransferase activity | Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate. |
| endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. |
| sterol 12-alpha-hydroxylase activity | Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O. |
| rna polymerase ii transcription coactivator activity | Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery. |
| atp:3'-cytidine-cytidine-trna adenylyltransferase activity | Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate. |
| long-chain fatty acid-coa ligase activity | Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
| alpha-amylase activity | Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units. |
| small conductance calcium-activated potassium channel activity | Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. |
| trna-specific adenosine deaminase activity | Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule. |
| phytoceramidase activity | Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine. |
| transferrin receptor activity | Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates. |
| radical sam enzyme activity | Catalysis of a reaction in which S-adenosyl-L-methionine (SAM) undergoes reductive cleavage to serve as a source of the 5'-deoxyadenosyl radical. |
| lysophospholipase activity | Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. |
| omega peptidase activity | Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups). |
| rap guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
| coreceptor activity | Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. |
| vascular endothelial growth factor receptor 3 binding | Interacting selectively and non-covalently with vascular endothelial growth factor receptor 3. |
| borate transmembrane transporter activity | Catalysis of the transport of borate across a membrane against the concentration gradient. |
| interleukin-27 binding | Interacting selectively and non-covalently with interleukin-27. |
| beta-adrenergic receptor kinase activity | Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor. |
| prenylated protein tyrosine phosphatase activity | Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate. |
| eukaryotic initiation factor eif2 binding | Interacting selectively and non-covalently with eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation. |
| voltage-gated chloride channel activity | Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| metallodipeptidase activity | Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| cyclin-dependent protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). |
| urotensin ii receptor activity | Combining with urotensin II to initiate a change in cell activity. |
| dol-p-man:man(6)glcnac(2)-pp-dol alpha-1,2-mannosyltransferase activity | Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. |
| rrna (adenine-n6-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine. |
| mannose-phosphate guanylyltransferase activity | Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule. |
| vitamin d receptor activator activity | Interacting (directly or indirectly) with vitamin D receptors such that the proportion of receptors in the active form is increased. |
| n-box binding | Interacting selectively and non-covalently with an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses. |
| histone deacetylase regulator activity | Modulates the activity of histone deacetylase. |
| myosin heavy chain binding | Interacting selectively and non-covalently with a heavy chain of a myosin complex. |
| g-protein coupled acetylcholine receptor activity | Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| transmembrane receptor protein tyrosine phosphatase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| hydroxymethylglutaryl-coa synthase activity | Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+). |
| inositol diphosphate tetrakisphosphate diphosphatase activity | Catalysis of the reaction: inositol diphosphate tetrakisphosphate + H2O = inositol 1,3,4,5,6-pentakisphosphate + phosphate. |
| pseudouridylate synthase activity | Catalysis of the reaction: D-ribose 5-phosphate + uracil = H(2)O + pseudouridine 5'-phosphate. |
| oxidoreductase activity, acting on the ch-nh2 group of donors | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
| interleukin-1, type ii, blocking receptor activity | Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors. |
| atp-gated ion channel activity | Catalysis of the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts. |
| histamine receptor activity | Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. |
| branched-chain-amino-acid transaminase activity | Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. |
| type 2 fibroblast growth factor receptor binding | Interacting selectively and non-covalently with the type 2 fibroblast growth factor receptor (FGFR2). |
| phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate. |
| poly(g) binding | Interacting selectively and non-covalently with a sequence of guanine residues in an RNA molecule. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
| protein phosphatase type 1 regulator activity | Modulation of the activity of the enzyme protein phosphatase type 1. |
| inositol monophosphate phosphatase activity | Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate. |
| mitochondrial light strand promoter anti-sense binding | Interacting selectively and non-covalently with the anti-sense strand of the light strand promoter, a promoter located on the light, or cytosine-rich, strand of mitochondrial DNA. |
| aromatic amino acid transmembrane transporter activity | Catalysis of the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring. |
| very-long-chain-(s)-2-hydroxy-acid oxidase activity | Catalysis of the reaction: very-long-chain (S)-2-hydroxy-acid + O2 = very-long-chain 2-oxo acid + hydrogen peroxide. Very long chain refers to a chain length of greater than 18 carbons. |
| xtp diphosphatase activity | Catalysis of the reaction: XTP + H2O = xanthosine 5'-phosphate + diphosphate. |
| phospholipid transporter activity | Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. |
| cdp-glycerol diphosphatase activity | Catalysis of the reaction: CDP-glycerol + H(2)O = sn-glycerol 3-phosphate + CMP + 2 H(+). |
| leak channel activity | Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state. |
| myosin v binding | Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. |
| exo-alpha-(2->3)-sialidase activity | Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates. |
| g-quadruplex dna binding | Interacting selectively and non-covalently with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome. |
| endothelin a receptor binding | Interacting selectively and non-covalently with an endothelin A receptor. |
| high-density lipoprotein particle receptor activity | Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis. |
| small protein activating enzyme binding | Interacting selectively and non-covalently with a small protein activating enzyme, such as ubiquitin-activating enzyme. |
| nucleosome binding | Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
| neuropeptide y receptor binding | Interacting selectively and non-covalently with a neuropeptide Y receptor. |
| misfolded protein binding | Interacting selectively and non-covalently with a misfolded protein. |
| cystine:glutamate antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out). |
| muramyl dipeptide binding | Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan. |
| microtubule minus-end binding | Interacting selectively and non-covalently with the minus end of a microtubule. |
| inositol-1,3,4-trisphosphate 1-phosphatase activity | Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate. |
| flap-structured dna binding | Interacting selectively and non-covalently with a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule. |
| [pyruvate dehydrogenase (lipoamide)] phosphatase activity | Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate. |
| acetyl-coa hydrolase activity | Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+). |
| n1-acetylspermine:oxygen oxidoreductase (n1-acetylspermidine-forming) activity | Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide. |
| aspartate-trna(asn) ligase activity | Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP. |
| gtp cyclohydrolase i activity | Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate. |
| icosatetraenoic acid binding | Interacting selectively and non-covalently with icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule. |
| phosphatidylinositol trisphosphate phosphatase activity | Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate. |
| corticotropin hormone receptor binding | Interacting selectively and non-covalently with a corticotropin hormone receptor. |
| 24-hydroxycholesterol 7alpha-hydroxylase activity | Catalysis of the reaction: (24R)-cholest-5-ene-3beta,24-diol + H(+) + NADPH + O(2) = (24R)-7alpha,24-dihydroxycholesterol + H(2)O + NADP(+). |
| protein-malonyllysine demalonylase activity | Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide. |
| argininosuccinate lyase activity | Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. |
| acireductone synthase activity | Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. |
| rna polymerase ii repressing transcription factor binding | Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription. |
| drug transmembrane transporter activity | Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. |
| type 5 melanocortin receptor binding | Interacting selectively and non-covalently with a type 5 melanocortin receptor. |
| endothelin b receptor binding | Interacting selectively and non-covalently with an endothelin B receptor. |
| uridine kinase activity | Catalysis of the reaction: ATP + uridine = ADP + UMP. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of two atoms of oxygen into one donor | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor. |
| camp response element binding protein binding | Interacting selectively and non-covalently with the cAMP response element binding protein. |
| udp-glycosyltransferase activity | Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. |
| cadmium ion transmembrane transporter activity | Catalysis of the transfer of cadmium (Cd) ions from one side of a membrane to the other. |
| g-protein coupled peptide receptor activity | Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| structural constituent of muscle | The action of a molecule that contributes to the structural integrity of a muscle fiber. |
| dynein intermediate chain binding | Interacting selectively and non-covalently with an intermediate chain of the dynein complex. |
| water transmembrane transporter activity | Enables the directed movement of water (H2O) from one side of a membrane to the other. |
| structural constituent of tooth enamel | The action of a molecule that contributes to the structural integrity of tooth enamel. |
| uniporter activity | Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species. |
| signaling adaptor activity | The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. |
| protein serine/threonine phosphatase inhibitor activity | Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. |
| heme transporter activity | Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells. |
| bitter taste receptor activity | Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste. |
| acid-ammonia (or amide) ligase activity | Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| biotin-[methylcrotonoyl-coa-carboxylase] ligase activity | Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)). |
| phospholipase a2 inhibitor activity | Stops, prevents or reduces the activity of the enzyme phospholipase A2. |
| heme-transporting atpase activity | Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out). |
| arylamine n-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. |
| molybdopterin adenylyltransferase activity | Catalysis of the reaction ATP + molybdopterin = diphosphate + adenylyl-molybdopterin. |
| hedgehog family protein binding | Interacting selectively and non-covalently with a member of the hedgehog protein family, signaling proteins involved in development. |
| monosialoganglioside sialyltransferase activity | Catalysis of the reaction: D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP-N-acetylneuraminate = N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP. |
| jun kinase binding | Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family. |
| nadh dehydrogenase (quinone) activity | Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol. |
| glucosylceramidase activity | Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. |
| rna polymerase ii transcription regulatory region sequence-specific dna binding transcription factor activity involved in negative regulation of transcription | Interacting selectively and non-covalently with a sequence of DNA that is in the regulatory region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| choline transmembrane transporter activity | Catalysis of the transfer of choline from one side of the membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. |
| n-acetylmuramoyl-l-alanine amidase activity | Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides. |
| copii adaptor activity | The binding activity of a molecule that brings together the COPII vesicle proteins and one or more other molecules, permitting them to function in a coordinated way. |
| deaminase activity | Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3). |
| c5l2 anaphylatoxin chemotactic receptor binding | Interacting selectively and non-covalently with a C5L2 anaphylatoxin chemotactic receptor. |
| o-palmitoyltransferase activity | Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule. |
| u4 snrna binding | Interacting selectively and non-covalently with the U4 small nuclear RNA (U4 snRNA). |
| cholecystokinin receptor binding | Interacting selectively and non-covalently with a cholecystokinin receptor. |
| alpha-actinin binding | Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. |
| protein binding involved in cell adhesion | Any protein binding that is involved in cell adhesion. |
| vitamin d receptor binding | Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes. |
| intronic transcription regulatory region sequence-specific dna binding | Interacting selectively and non-covalently with an intronic DNA sequence that regulates the transcription of the transcript it is contained within. |
| superoxide-generating nadph oxidase activity | Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-. |
| glyoxalase iii activity | Catalysis of the reaction: methylglyoxal + H2O = D-lactate. |
| rna polymerase ii transcription factor binding | Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II. |
| protein homodimerization activity | Interacting selectively and non-covalently with an identical protein to form a homodimer. |
| calcium activated cation channel activity | Catalysis of the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient. |
| enoyl-[acyl-carrier-protein] reductase (nadph, a-specific) activity | Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+. |
| nadph-hemoprotein reductase activity | Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein. |
| 5'-3' exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule. |
| neuroligin family protein binding | Interacting selectively and non-covalently with a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation. |
| phenanthrene-9,10-epoxide hydrolase activity | Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene. |
| proton-dependent peptide secondary active transmembrane transporter activity | Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement. |
| interleukin-5 receptor activity | Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| retinol transporter activity | Enables the directed movement of retinol into, out of or within a cell, or between cells. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. |
| scavenger receptor activity | Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). |
| thyroid hormone transmembrane transporter activity | Catalysis of the transfer of thyroid hormones from one side of the membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. |
| thyroxine 5-deiodinase activity | |
| proline:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in). |
| adrenomedullin receptor activity | Combining with adrenomedullin to initiate a change in cell activity. |
| collagen binding | Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). |
| primary active transmembrane transporter activity | Catalysis of the transfer of a solute from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source, directly using ATP. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources. |
| platelet-derived growth factor binding | Interacting selectively and non-covalently with platelet-derived growth factor. |
| cyclic-gmp-amp synthase activity | Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP. |
| inositol tetrakisphosphate kinase activity | Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP. |
| transferase activity, transferring nitrogenous groups | Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). |
| scaffold protein binding | Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. |
| glycine binding | Interacting selectively and non-covalently with glycine, aminoethanoic acid. |
| peptidyl-cysteine s-nitrosylase activity | Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein. |
| gmp synthase activity | Catalysis of the reaction: ATP + xanthosine 5'-phosphate + NH3 = AMP + diphosphate + GMP. |
| nitrate reductase activity | Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor. |
| ubiquinone binding | Interacting selectively and non-covalently with ubiquinone, a quinone derivative with a tail of isoprene units. |
| sialyltransferase activity | Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. |
| dynein heavy chain binding | Interacting selectively and non-covalently with a heavy chain of the dynein complex. |
| arginine n-methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue. |
| ligand-activated rna polymerase ii transcription factor binding transcription factor activity | Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, some steroid hormone receptors bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain hormone response elements. |
| c-c chemokine receptor activity | Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. |
| glutathione synthase activity | Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate. |
| ionotropic glutamate receptor binding | Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. |
| valine-trna ligase activity | Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+). |
| diazepam binding | Interacting selectively and non-covalently with diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium. |
| platelet-derived growth factor receptor binding | Interacting selectively and non-covalently with the platelet-derived growth factor receptor. |
| cdp-diacylglycerol-inositol 3-phosphatidyltransferase activity | Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+). |
| aminoacyl-trna ligase activity | Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. |
| triose-phosphate isomerase activity | Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate. |
| taste receptor activity | Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. |
| k63-linked polyubiquitin binding | Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers. |
| transcription factor recruiting transcription factor activity | Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, and with another protein, macromolecule, or complex, recruiting that specific transcription factor to the transcription machinery complex and thus permitting those molecules to function in a coordinated way, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. |
| transmembrane electron transfer carrier | Enables electron flow across a biological membrane, from donors localized on one side of the membrane to acceptors localized on the other side. These systems contribute to or subtract from the membrane potential, depending on the direction of electron flow. They are therefore important to cellular energetics. |
| choline o-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA. |
| iduronate-2-sulfatase activity | Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S --> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate. Note that this may include the extension of ubiquitin chains. |
| dna-3-methylbase glycosylase activity | Catalysis of the reaction: DNA containing 3-methylbase + H2O = DNA with abasic site + 3-methylbase. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylpurine or 3-methylpyrimidine base and the deoxyribose sugar to remove the methylated base, leaving an apurinic or apyrimidinic site. |
| 23s rrna (adenine(1618)-n(6))-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA. |
| lysine n-acetyltransferase activity, acting on acetyl phosphate as donor | Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine. |
| galactosyltransferase activity | Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
| fumarylacetoacetase activity | Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+). |
| interferon-gamma binding | Interacting selectively and non-covalently with interferon-gamma. Interferon gamma is the only member of the type II interferon found so far. |
| at dna binding | Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA). |
| sugar transmembrane transporter activity | Catalysis of the transfer of a sugar from one side of the membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. |
| trna-intron endonuclease activity | Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. |
| type 1 fibroblast growth factor receptor binding | Interacting selectively and non-covalently with the type 1 fibroblast growth factor receptor (FGFR1). |
| benzodiazepine receptor binding | Interacting selectively and non-covalently with the peripheral benzodiazepine receptor (PBR). |
| methyl-cpnpg binding | Interacting selectively and non-covalently with a methylated cytosine/unspecified/guanine trinucleotide. |
| interleukin-1 type i receptor antagonist activity | Blocks the binding of interleukin-1 to interleukin-1 Type I receptors. |
| rna polymerase ii transcription regulatory region sequence-specific dna binding transcription factor activity involved in positive regulation of transcription | Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. |
| atp-dependent 5'-3' dna helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'. |
| peptidase activity, acting on l-amino acid peptides | Catalysis of the hydrolysis of peptide bonds formed between L-amino acids. |
| peroxisomal fatty-acyl-coa transporter activity | Catalysis of the reaction: ATP + H2O + fatty acyl CoA(cis) = ADP + phosphate + fatty acyl CoA(trans). The transport of fatty acyl CoA into and out of peroxisomes. |
| histone demethylase activity (h3-k27 specific) | Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein. |
| rrna (cytosine-n4-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine. |
| oxidosqualene cyclase activity | Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene. |
| l-ascorbic acid transporter activity | Enables the directed movement of L-ascorbate into, out of or within a cell, or between cells. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species. |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. |
| lrr domain binding | Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein. |
| phosphatidylinositol-3-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate. |
| follicle-stimulating hormone receptor binding | Interacting selectively and non-covalently with a follicle-stimulating hormone receptor. |
| insulin receptor binding | Interacting selectively and non-covalently with the insulin receptor. |
| follicle-stimulating hormone receptor activity | Combining with follicle-stimulating hormone to initiate a change in cell activity. |
| serpin family protein binding | Interacting selectively and non-covalently with any member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a noninhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors. |
| modified amino acid binding | Interacting selectively and non-covalently with a modified amino acid. |
| nucleocytoplasmic transporter activity | Enables the directed movement of substances between the nucleus and the cytoplasm of a cell. |
| glyceraldehyde-3-phosphate dehydrogenase (nad+) (phosphorylating) activity | Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. |
| dna replication origin binding | Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. |
| l-hydroxyproline transmembrane transporter activity | Catalysis of the transfer of L-hydroxyproline from one side of a membrane to the other. |
| 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity | Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]. |
| g-protein coupled glutamate receptor binding | Interacting selectively and non-covalently with a G-protein coupled glutamate receptor (a metabotropic glutamate receptor). |
| alpha-1a adrenergic receptor binding | Interacting selectively and non-covalently with an alpha-1A adrenergic receptor. |
| betaine-homocysteine s-methyltransferase activity | Catalysis of the reaction: L-homocysteine + betaine = N,N-dimethylglycine + L-methionine. |
| vitamin transporter activity | Enables the directed movement of vitamins into, out of or within a cell, or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. |
| neuropeptide receptor binding | Interacting selectively and non-covalently with a neuropeptide receptor. |
| phosphoribosylglycinamide formyltransferase activity | Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. |
| methylmalonyl-coa decarboxylase activity | Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2. |
| phosphatidylethanolamine binding | Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. |
| acetylgalactosaminyltransferase activity | Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide. |
| amine binding | Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group. |
| 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity | Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O. |
| l-threonine ammonia-lyase activity | Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3. |
| ral guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ral family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
| voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| kinesin binding | Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. |
| sulfonylurea receptor binding | Interacting selectively and non-covalently with the sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel. |
| quinine 3-monooxygenase activity | Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+). |
| tubulin-dependent atpase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate. |
| mitochondrial light strand promoter sense binding | Interacting selectively and non-covalently with the sense strand of the light strand promoter, a promoter located on the light, or cytosine-rich, strand of mitochondrial DNA. |
| arginyltransferase activity | Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein. |
| anion transmembrane transporter activity | Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other. |
| long-chain fatty acid binding | Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
| phosphatidylinositol phospholipase c activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+). |
| sumo activating enzyme activity | Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond. |
| sodium-dependent phosphate transmembrane transporter activity | Catalysis of the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other, requiring sodium ions. |
| glyoxalase (glycolic acid-forming) activity | Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor. |
| phospholipase a2 activity | Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. |
| activin-activated receptor activity | Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta. |
| calcitonin binding | Interacting selectively and non-covalently with calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid. |
| atg8 activating enzyme activity | Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond. |
| glutamic-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad. |
| ferrous iron uptake transmembrane transporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) + energy = Fe2+(in). |
| high-affinity basic amino acid transmembrane transporter activity | Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. |
| phosphatidylinositol-4-phosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. |
| retinal isomerase activity | Catalysis of the reaction: all-trans-retinal = 11-cis-retinal. |
| monooxygenase activity | Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. |
| sumo-specific protease activity | Catalysis of the hydrolysis of SUMO, a small ubiquitin-related modifier, from previously sumoylated substrates. |
| lipoteichoic acid receptor activity | Combining with lipoteichoic acid and transmitting the signal to initiate a change in cell activity. |
| morphine receptor activity | Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein. |
| cation transmembrane transporter activity | Catalysis of the transfer of cation from one side of the membrane to the other. |
| beta-ureidopropionase activity | Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3. |
| fibroblast growth factor receptor binding | Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR). |
| phospholipase activity | Catalysis of the hydrolysis of a glycerophospholipid. |
| voltage-gated calcium channel activity involved sa node cell action potential | Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| adenylate cyclase inhibitor activity | Decreases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate. |
| interleukin-22 binding | Interacting selectively and non-covalently with interleukin-22. |
| poly(c) rna binding | Interacting selectively and non-covalently with a sequence of cytosine residues in an RNA molecule. |
| biotin-[acetyl-coa-carboxylase] ligase activity | Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)). |
| cation-transporting atpase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). |
| poly(a)-specific ribonuclease activity | Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. |
| diphthine synthase activity | Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine. |
| n-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity | Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP. |
| bile acid binding | Interacting selectively and non-covalently with bile acids, any of a group of steroid carboxylic acids occurring in bile. |
| nucleobase binding | Interacting selectively and non-covalently with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases. |
| heme oxygenase (decyclizing) activity | Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O. |
| fucose-1-phosphate guanylyltransferase activity | Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP = diphosphate + GDP-L-fucose. |
| [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity | Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S. |
| basic amino acid transmembrane transporter activity | Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7. |
| chemokine (c-c motif) ligand 19 binding | Interacting selectively and non-covalently with chemokine (C-C motif) ligand 19. |
| farnesyl-diphosphate farnesyltransferase activity | Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate. |
| histone demethylase activity (h3-trimethyl-k4 specific) | Catalysis of the removal of a methyl group from trimethylated lysine at position 4 of the histone H3 protein. |
| igg receptor activity | Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| peroxisome matrix targeting signal-2 binding | Interacting selectively and non-covalently with a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F). |
| mrna (guanine-n7-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine. |
| galactosylxylosylprotein 3-beta-galactosyltransferase activity | Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP. |
| mhc class i protein binding | Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. |
| interleukin-6 binding | Interacting selectively and non-covalently with interleukin-6. |
| l-ornithine transmembrane transporter activity | Catalysis of the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid. |
| peptide-methionine (r)-s-oxide reductase activity | Catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. |
| heparan sulfate n-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate. |
| proteinase activated receptor binding | Interacting selectively and non-covalently with a proteinase activated receptor. |
| phosphogluconate dehydrogenase (decarboxylating) activity | Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. |
| poly(adp-ribose) glycohydrolase activity | Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose. |
| endopeptidase inhibitor activity | Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. |
| nucleic acid transmembrane transporter activity | Catalysis of the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information. |
| rho gtpase binding | Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton. |
| alpha-1,3-galactosyltransferase activity | Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage. |
| endoribonuclease activity, cleaving sirna-paired mrna | Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters. |
| peptide:proton symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in). Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement. |
| cholesterol monooxygenase (side-chain-cleaving) activity | Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O. |
| glucuronyl-galactosyl-proteoglycan 4-alpha-n-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan. |
| acp phosphopantetheine attachment site binding involved in fatty acid biosynthetic process | Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis. |
| single guanine insertion binding | Interacting selectively and non-covalently with double-stranded DNA containing a single guanine insertion or a deletion that results in an unpaired guanine. |
| phosphatidylinositol-4,5-bisphosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor. |
| arginine-trna ligase activity | Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). |
| succinyl-coa hydrolase activity | Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate. |
| nickel cation transmembrane transporter activity | Catalysis of the transfer of nickel (Ni) cations from one side of a membrane to the other. |
| trimethylamine receptor activity | Combining with the biogenic amine trimethylamine to initiate a change in cell activity. |
| inositol hexakisphosphate kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown. |
| gpi anchor binding | Interacting selectively and non-covalently with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes. |
| adp-activated nucleotide receptor activity | Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by ADP. |
| corticotropin-releasing hormone binding | Interacting selectively and non-covalently with corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland. |
| dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity | Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine. |
| immunoglobulin receptor activity | Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| ligase activity, forming carbon-sulfur bonds | Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| adenine transmembrane transporter activity | Catalysis of the transfer of adenine, 6-aminopurine, from one side of a membrane to the other. |
| myristoyl-[acyl-carrier-protein] hydrolase activity | Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate. |
| n-acylphosphatidylethanolamine-specific phospholipase d activity | Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE). |
| adrenergic receptor binding | Interacting selectively and non-covalently with an adrenergic receptor. |
| insulin-like growth factor receptor binding | Interacting selectively and non-covalently with the insulin-like growth factor receptor. |
| bradykinin receptor binding | Interacting selectively and non-covalently with a bradykinin receptor. |
| hla-b specific inhibitory mhc class i receptor activity | Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte. |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+). |
| rna 7-methylguanosine cap binding | Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. |
| toll-like receptor 2 binding | Interacting selectively and non-covalently with a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response. |
| oxidoreductase activity, acting on nad(p)h | Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
| single-stranded dna-dependent atp-dependent dna helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix. |
| rna-dependent atpase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction. |
| neurotrophin trkb receptor binding | Interacting selectively and non-covalently with the neurotrophin TRKB receptor. |
| albendazole monooxygenase activity | Catalysis of the reaction: albendazole + H(+) + NADPH + O(2) = albendazole S-oxide + H(2)O + NADP(+). |
| sulfur dioxygenase activity | Catalysis of the reaction: sulfur + O2 + H2O = sulfite. |
| glycine n-choloyltransferase activity | Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate. |
| au-rich element binding | Interacting selectively and non-covalently with a region of RNA containing frequent adenine and uridine bases. |
| single-stranded dna-dependent atpase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction. |
| steryl-sulfatase activity | Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate. |
| fucosylgalactoside 3-alpha-galactosyltransferase activity | Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose. |
| alpha-1,6-mannosylglycoprotein 6-beta-n-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors. |
| enzyme activator activity | Increases the activity of an enzyme. |
| methotrexate transporter activity | Enables the directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase. |
| glycerol transmembrane transporter activity | Catalysis of the transfer of glycerol from one side of the membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. |
| calcium-dependent protein kinase regulator activity | Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner. |
| metalloaminopeptidase activity | Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| protein serine/threonine phosphatase activity | Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. |
| intramolecular oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. |
| chemokine receptor antagonist activity | Interacts with chemokine receptors to reduce the action of a chemokine. |
| glutamine n-acyltransferase activity | Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine. |
| folic acid transporter activity | Enables the directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. |
| epinephrine binding | Interacting selectively and non-covalently with epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. |
| histone acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. |
| clathrin binding | Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. |
| disulfide oxidoreductase activity | Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. |
| acrosin binding | Interacting selectively and non-covalently with acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities. |
| fas-activated serine/threonine kinase activity | Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein. |
| sour taste receptor activity | Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste. |
| racemase and epimerase activity, acting on amino acids and derivatives | Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid. |
| serotonin binding | Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. |
| leptin receptor binding | Interacting selectively and non-covalently with the leptin receptor. |
| cysteine-type endopeptidase regulator activity involved in apoptotic process | Modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process. |
| histone deacetylase activity (h4-k16 specific) | Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein. |
| scavenger receptor binding | Interacting selectively and non-covalently with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles. |
| glycogen binding | Interacting selectively and non-covalently with glycogen. |
| trans-octaprenyltranstransferase activity | Catalysis of the reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + diphosphate. |
| nadp binding | |
| oxidoreductase activity, acting on the ch-oh group of donors, cytochrome as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule. |
| rna polymerase i regulatory region sequence-specific dna binding | Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I. |
| single-stranded dna 5'-3' exodeoxyribonuclease activity | Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule. |
| toxin transporter activity | Enables the directed movement of a toxin into, out of or within a cell, or between cells. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. |
| 3-beta-hydroxy-delta5-steroid dehydrogenase activity | Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+). |
| glycolate oxidase activity | Catalysis of the reaction: glycolate + O2 = glyoxylate + hydrogen peroxide. |
| mads box domain binding | Interacting selectively and non-covalently with a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs. |
| myosin phosphatase activity | Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. |
| coenzyme a transmembrane transporter activity | Enables the directed movement of coenzyme A across a membrane into, out of or within a cell, or between cells. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. |
| enzyme binding | Interacting selectively and non-covalently with any enzyme. |
| oxidized base lesion dna n-glycosylase activity | Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. |
| type 3 galanin receptor binding | Interacting selectively and non-covalently with a type 3 galanin receptor. |
| taurine transmembrane transporter activity | Catalysis of the transfer of taurine from one side of the membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats. |
| voltage-gated proton channel activity | Catalysis of the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| organic anion transmembrane transporter activity | Catalysis of the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. |
| cholesterol 24-hydroxylase activity | Catalysis of the reaction: cholesterol + H(+) + NADPH + O(2) = (24S)-24-hydroxycholesterol + H(2)O + NADP(+). |
| arachidonate-coa ligase activity | Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+). |
| calcium-dependent protein serine/threonine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions are dependent on the presence of calcium ions. |
| histone kinase activity (h2a-t120 specific) | Catalysis of the transfer of a phosphate group to the threonine-120 residue of histone H2A. |
| phenanthrene 9,10-monooxygenase activity | Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide. |
| mhc protein complex binding | Interacting selectively and non-covalently with the major histocompatibility complex. |
| siderophore transporter activity | Enables the directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells. |
| histone-glutamine methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-glutamine = S-adenosyl-L-homocysteine + (histone)-N5-methyl-glutamine. |
| protein geranylgeranyltransferase activity | Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. |
| 3-demethylubiquinone-9 3-o-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9. |
| camp-dependent protein kinase regulator activity | Modulation of the activity of the enzyme cAMP-dependent protein kinase. |
| gtpase binding | Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP. |
| clathrin heavy chain binding | Interacting selectively and non-covalently with a clathrin heavy chain. |
| phosphatidylinositol 3-kinase binding | Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. |
| kdel sequence binding | Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum. |
| lipid phosphatase activity | Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate. |
| oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. |
| dihydrolipoyllysine-residue acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide. |
| medium-chain-acyl-coa dehydrogenase activity | Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12. |
| dihydrofolate reductase activity | Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. |
| extracellular ligand-gated ion channel activity | Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts. |
| aspartate-trna ligase activity | Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). |
| voltage-gated sodium channel activity involved in av node cell action potential | Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| l27 domain binding | Interacting selectively and non-covalently with a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner. |
| beta-glucosidase activity | Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. |
| iron-cytochrome-c reductase activity | Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+. |
| histone kinase activity (h3-t3 specific) | Catalysis of the transfer of a phosphate group to the threonine-3 residue of the N-terminal tail of histone H3. |
| protein methyltransferase activity | Catalysis of the transfer of a methyl group (CH3-) to a protein. |
| rna polymerase ii core promoter proximal region sequence-specific dna binding transcription factor activity involved in positive regulation of transcription | Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. |
| tfiid-class transcription factor binding | Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor. |
| ceramide 1-phosphate transporter activity | Enables the directed movement of ceramide 1-phosphate into, out of or within a cell, or between cells. |
| mercury (ii) reductase activity | Catalysis of the reaction: H(+) + Hg + NADP(+) = Hg(2+) + NADPH. |
| cyclic pyranopterin monophosphate synthase activity | Catalysis of the reaction GTP = cyclic pyranopterin phosphate + diphosphate. |
| protein complex binding | Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
| isocitrate dehydrogenase activity | Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor. |
| (s)-2-hydroxy-acid oxidase activity | Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide. |
| transition metal ion binding | Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. |
| complement component c4b binding | Interacting selectively and non-covalently with the C4b product of the classical complement cascade. |
| sh3/sh2 adaptor activity | Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68). |
| transmitter-gated ion channel activity | Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts. |
| ornithine decarboxylase activator activity | Upregulation of the activity of the enzyme ornithine decarboxylase. |
| 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity | Catalysis of the reaction: a (3R)-3-hydroxyacyl-[acyl-carrier protein] = H2O + a trans-delta2-enoyl-acyl-[acyl-carrier protein]. |
| dgtpase activity | Catalysis of the reaction: dGTP + H(2)O = 2'-deoxyguanosine + 2 H(+) + triphosphate. |
| 3',5'-cyclic-amp phosphodiesterase activity | Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. |
| udp-n-acetylglucosamine 4-epimerase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine. |
| creatine transmembrane transporter activity | Enables the directed movement of creatine across a membrane. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. |
| malonyl-coa synthetase activity | Catalysis of the reaction: malonate + ATP + coenzyme A = malonyl-CoA + AMP + diphosphate. |
| hormone-sensitive lipase activity | Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate. |
| lysophosphatidic acid receptor activity | Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein. |
| store-operated calcium channel activity | A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. |
| nitric oxide transmembrane transporter activity | Enables the directed movement of nitric oxide, nitrogen monoxide, from one side of a membrane to the other. |
| trna (adenine-n1-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine. |
| protein-glutamine gamma-glutamyltransferase activity | Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. |
| calmodulin binding | Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| pre-mrna intronic binding | Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA). |
| insulin-like growth factor-activated receptor activity | Combining with insulin-like growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| g-protein coupled amine receptor activity | Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| interleukin-4 receptor binding | Interacting selectively and non-covalently with the interleukin-4 receptor. |
| phosphatidylcholine-sterol o-acyltransferase activator activity | Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines. |
| channel-conductance-controlling atpase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels. |
| squalene monooxygenase activity | Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+). |
| oxidoreductase activity, oxidizing metal ions with flavin as acceptor | Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and flavin acts as an electron acceptor. |
| armadillo repeat domain binding | Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation. |
| snrna binding | Interacting selectively and non-covalently with a small nuclear RNA (snRNA). |
| lamin binding | Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. |
| quercetin 2,3-dioxygenase activity | Catalysis of the reaction: H(+) + O(2) + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO. |
| myosin ii binding | Interacting selectively and non-covalently with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin. |
| phosphatidylcholine-retinol o-acyltransferase activity | Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine. |
| retinoid x receptor binding | Interacting selectively and non-covalently with a retinoid X receptor. |
| magnesium ion transmembrane transporter activity | Catalysis of the transfer of magnesium (Mg) ions from one side of a membrane to the other. |
| histidine ammonia-lyase activity | Catalysis of the reaction: L-histidine = urocanate + NH3. |
| cupric reductase activity | Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH. |
| metalloendopeptidase inhibitor activity | Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. |
| phosphofructokinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a fructose substrate molecule. |
| rna uridylyltransferase activity | Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1). |
| interleukin-23 receptor binding | Interacting selectively and non-covalently with the interleukin-23 receptor. |
| semaphorin receptor activity | Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| aconitate hydratase activity | Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate. |
| mismatch repair complex binding | Interacting selectively and non-covalently with a mismatch repair complex. |
| delta24-sterol reductase activity | Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol. |
| toxic substance binding | Interacting selectively and non-covalently with a toxic substance, a poisonous substance that causes damage to biological systems. |
| ethanolamine-phosphate phospho-lyase activity | Catalysis of the reaction: H(2)O + phosphoethanolamine = acetaldehyde + NH(4)(+) + phosphate. |
| arsenite methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate. |
| amino-acid racemase activity | Catalysis of the reaction: an L-amino acid = a D-amino acid. |
| nad-dependent histone deacetylase activity (h3-k14 specific) | Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein. |
| 15-hydroxyprostaglandin dehydrogenase (nadp+) activity | Catalysis of the reaction: NADP(+) + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H(+) + NADPH. |
| hydrogen ion channel activity | Catalysis of facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| ww domain binding | Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. |
| ubiquitin-like protein conjugating enzyme activity | |
| transcription corepressor binding | Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery. |
| mrna binding | Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| kynurenine-glyoxylate transaminase activity | Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine. |
| oligosaccharyl transferase activity | Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
| manganese ion binding | Interacting selectively and non-covalently with manganese (Mn) ions. |
| carbon-nitrogen lyase activity | Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99). |
| ion channel inhibitor activity | Stops, prevents, or reduces the activity of an ion channel. |
| rna polymerase ii core promoter sequence-specific dna binding transcription factor activity involved in preinitiation complex assembly | Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter. |
| calcium-dependent protein kinase activity | Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the presence of calcium. |
| d-aminoacyl-trna deacylase activity | Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA. |
| interleukin-9 receptor activity | Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| ether hydrolase activity | Catalysis of the hydrolysis of an ether bond, -O-. |
| g-protein coupled receptor kinase activity | Catalysis of the reaction: ATP + G-protein coupled receptor = ADP + G-protein coupled receptor phosphate. |
| riboflavin kinase activity | Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+). |
| omega-amidase activity | Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3. |
| interleukin-6 receptor activity | Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| glucose 1-dehydrogenase [nad(p)] activity | |
| transferase activity, transferring acyl groups | Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). |
| cdp-alcohol phosphatidyltransferase activity | Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol. |
| ran guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ran family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
| card domain binding | Interacting selectively and non-covalently with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family. |
| corticotropin-releasing hormone receptor activity | Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity. |
| beta-1,3-galactosyltransferase activity | Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage. |
| g-protein activated inward rectifier potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. |
| alpha-methylacyl-coa racemase activity | Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA. |
| [heparan sulfate]-glucosamine n-sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine. |
| c-c motif chemokine 19 receptor activity | Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| protein phosphatase binding | Interacting selectively and non-covalently with any protein phosphatase. |
| oligo-1,6-glucosidase activity | Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose. |
| signal sequence binding | Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. |
| bile-salt sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate. |
| carbon-oxygen lyase activity | Catalysis of the breakage of a carbon-oxygen bond. |
| triglyceride lipase activity | Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. |
| fatty-acyl-coa transporter activity | Enables the directed movement of a fatty acyl CoA group into, out of or within a cell, or between cells. A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A group attached to it. |
| ankyrin repeat binding | Interacting selectively and non-covalently with an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure. |
| ganglioside binding | Interacting selectively and non-covalently with a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues. |
| alditol:nadp+ 1-oxidoreductase activity | Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. |
| lipoprotein lipase activator activity | Increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein. |
| gtp diphosphatase activity | Catalysis of the reaction: GTP + H2O = GMP + diphosphate. |
| threonine-trna ligase activity | Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). |
| nad+ binding | |
| glucose-6-phosphate transmembrane transporter activity | Catalysis of the transfer of glucose-6-phosphate from one side of the membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6. |
| inositol tetrakisphosphate 1-kinase activity | Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. |
| ribose phosphate diphosphokinase activity | Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+). |
| intracellular cyclic nucleotide activated cation channel activity | Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts. |
| phosphorelay sensor kinase activity | Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. |
| atpase activity, coupled to transmembrane movement of ions, rotational mechanism | Catalysis of the transfer of ions from one side of a membrane to the other according to the reaction: ATP + H2O + ion(in) = ADP + phosphate + ion(out), by a rotational mechanism. |
| rrna (cytosine) methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine. |
| diphosphomevalonate decarboxylase activity | Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate. |
| oxidoreductase activity, acting on the ch-ch group of donors | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
| 3'-5' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. |
| anion:anion antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out). |
| interleukin-10 receptor activity | Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| sterol o-acyltransferase activity | Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester. |
| cyclo-ligase activity | Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| n-acylneuraminate-9-phosphatase activity | Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate. |
| hydroxymethyl-, formyl- and related transferase activity | Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor). |
| d-glucose transmembrane transporter activity | Catalysis of the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of the membrane to the other. |
| sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity | Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8. |
| carboxyl-o-methyltransferase activity | Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester. |
| deoxynucleoside kinase activity | Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate. |
| nucleosomal histone binding | Interacting selectively and non-covalently with a histone that is assembled into a nucleosome. |
| xylulokinase activity | Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H(+). |
| n(1),n(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity | Catalysis of the reaction: H(2)O + N(1),N(12)-diacetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + N(1)-acetylspermidine. |
| map kinase tyrosine/serine/threonine phosphatase activity | Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate. |
| atp-dependent 5'-3' dna/rna helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex in the direction 5' to 3'. |
| glycerone-phosphate o-acyltransferase activity | Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA. |
| lactosylceramide 1,3-n-acetyl-beta-d-glucosaminyltransferase activity | Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP. |
| vitamin transmembrane transporter activity | Enables the transfer of a vitamin from one side of a membrane to the other. |
| protein kinase a regulatory subunit binding | Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A. |
| n,n-dimethylaniline monooxygenase activity | Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. |
| inositol-polyphosphate 5-phosphatase activity | Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. |
| serine c-palmitoyltransferase activity | Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA. |
| arylesterase activity | Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. |
| n-acyltransferase activity | Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. |
| inorganic diphosphatase activity | Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate. |
| alpha-galactosidase activity | Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase. |
| clathrin light chain binding | Interacting selectively and non-covalently with a clathrin light chain. |
| sam domain binding | Interacting selectively and non-covalently with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes. |
| copper ion binding | Interacting selectively and non-covalently with copper (Cu) ions. |
| insulin-activated receptor activity | Combining with insulin and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| galactosylceramide sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate. |
| tap1 binding | Interacting selectively and non-covalently with the TAP1 subunit of TAP (transporter associated with antigen processing) protein. |
| propionyl-coa carboxylase activity | Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA. |
| 8-hydroxy-dadp phosphatase activity | Catalysis of the reaction8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate. |
| oxidoreductase activity, acting on ch or ch2 groups | Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
| growth factor binding | Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. |
| unfolded protein binding | Interacting selectively and non-covalently with an unfolded protein. |
| core promoter sequence-specific dna binding | Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. |
| exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. |
| alcohol dehydrogenase activity, zinc-dependent | Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc. |
| receptor signaling protein serine/threonine phosphatase activity | Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. |
| beta-alanine-pyruvate transaminase activity | Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine. |
| volume-sensitive chloride channel activity | Catalysis of the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell. |
| magnesium ion binding | Interacting selectively and non-covalently with magnesium (Mg) ions. |
| cholesterol transporter activity | Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
| peroxisome targeting sequence binding | Interacting selectively and non-covalently with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome. |
| endoribonuclease activity | Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. |
| glycine-trna ligase activity | Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). |
| receptor regulator activity | The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed. |
| sulfide:quinone oxidoreductase activity | Catalysis of the reaction: hydrogen sulfide + a quinone = S0 + a hydroquinone. |
| carboxylic acid transmembrane transporter activity | Catalysis of the transfer of carboxylic acids from one side of the membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). |
| 2-aminoadipate transaminase activity | Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate. |
| dioxygenase activity | Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. |
| arachidonic acid 11,12-epoxygenase activity | Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid. |
| c-x3-c chemokine receptor activity | Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif. |
| transcription termination site dna binding | Interacting selectively and non-covalently with a region of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon. |
| [methionine synthase] reductase activity | Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+. |
| nucleoside kinase activity | Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. |
| adenosylhomocysteinase activity | Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. |
| phosphoribosylaminoimidazole carboxylase activity | Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2). |
| polyribonucleotide kinase activity | Catalysis of the reaction: NTP + 5'-dephospho-RNA = NDP + 5'-phospho-RNA. |
| cyclic nucleotide-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a cyclic nucleotide. |
| electron-transferring-flavoprotein dehydrogenase activity | Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol. |
| l-phenylalanine aminotransferase activity | Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid. |
| integrin binding | Interacting selectively and non-covalently with an integrin. |
| prosthetic group binding | Interacting selectively and non-covalently with a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. |
| calcium- and calmodulin-regulated 3',5'-cyclic-gmp phosphodiesterase activity | Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. The reaction is calmodulin and calcium-sensitive. |
| l-phenylalanine-oxaloacetate transaminase activity | Catalysis of the reaction L-phenylalanine + oxaloacetate = phenylpyruvate + aspartate. |
| chitin binding | Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. |
| oxidized pyrimidine nucleobase lesion dna n-glycosylase activity | Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. |
| protein n-terminus binding | Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
| polymeric immunoglobulin receptor activity | Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. |
| 2-alkenal reductase [nad(p)] activity | |
| globoside alpha-n-acetylgalactosaminyltransferase activity | Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP. |
| udp-n-acetylmuramate dehydrogenase activity | Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+. |
| dna-n1-methyladenine dioxygenase activity | Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA and RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde. |
| tap2 binding | Interacting selectively and non-covalently with the TAP2 subunit of TAP (transporter associated with antigen processing) protein. |
| calcium-induced calcium release activity | Release of calcium ions from an intracellular vesicle on induction by increased calcium concentration. |
| sumo conjugating enzyme activity | Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y -> Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue. |
| eukaryotic translation initiation factor 2alpha kinase activity | Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate. |
| glycogen phosphorylase activity | Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate. |
| adp-ribosylation factor binding | Interacting selectively and non-covalently with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells. |
| anion channel activity | Catalysis of the energy-independent passage of anions across a lipid bilayer down a concentration gradient. |
| nad+ synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate. |
| peptide-glutamate-n-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide. |
| diacylglycerol cholinephosphotransferase activity | Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine. |
| uridine-diphosphatase activity | Catalysis of the reaction: UDP + H2O = UMP + phosphate. |
| phosphatidylcholine 1-acylhydrolase activity | Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate. |
| nucleic acid binding | Interacting selectively and non-covalently with any nucleic acid. |
| carbohydrate binding | Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| oxoglutarate dehydrogenase (nad+) activity | Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH. |
| phosphothreonine binding | Interacting selectively and non-covalently with a phosphorylated threonine residue within a protein. |
| myosin-light-chain-phosphatase activity | Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate. |
| ribonucleoprotein complex binding | Interacting selectively and non-covalently with any complex of RNA and protein. |
| extracellular matrix constituent, lubricant activity | Functions as a lubricant for an extracellular matrix, such as a mucous membrane. |
| n-terminal protein n-methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser. |
| citrate synthase activity | Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA. |
| bisphosphoglycerate phosphatase activity | Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = phosphoglycerate + phosphate. |
| phosphatase regulator activity | Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. |
| dol-p-man:man(5)glcnac(2)-pp-dol alpha-1,3-mannosyltransferase activity | Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. |
| glucuronosyltransferase activity | Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. |
| sequence-specific transcription regulatory region dna binding rna polymerase ii transcription factor recruiting transcription factor activity | Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA by RNA polymerase II and recruiting another transcription factor to the DNA in order to modulate transcription by RNAP II. |
| l-amino-acid oxidase activity | Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide. |
| dolichyl-phosphate beta-d-mannosyltransferase activity | Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate. |
| sphingomyelin phosphodiesterase activity | Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+). |
| n-acylglucosamine 2-epimerase activity | Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine. |
| inorganic cation transmembrane transporter activity | Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. |
| collagen v binding | Interacting selectively and non-covalently with a type V collagen trimer. |
| mhc class i receptor activity | Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules. |
| udp-n-acetylglucosamine diphosphorylase activity | Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine. |
| interleukin-23 binding | Interacting selectively and non-covalently with interleukin-23. |
| folic acid binding | Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. |
| phosphoglycerate mutase activity | Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate. |
| guanine/thymine mispair binding | Interacting selectively and non-covalently with double-stranded DNA containing a G/T mispair. |
| saccharopine dehydrogenase (nad+, l-glutamate-forming) activity | Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = L-glutamate + allysine + H(+) + NADH. |
| nitric oxide binding | Interacting selectively and non-covalently with nitric oxide (NO). |
| pristanate-coa ligase activity | Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA. |
| butyrate-coa ligase activity | Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA. |
| insulin-like growth factor binding | Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it. |
| chylomicron binding | Interacting selectively and non-covalently with a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. |
| l-fuconate dehydratase activity | Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H(2)O. |
| formaldehyde dehydrogenase activity | Catalysis of the reaction: formaldehyde + H(2)O + NAD(+) = formate + 2 H(+) + NADH. |
| histone methyltransferase activity (h4-r3 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4. |
| 3-dehydrosphinganine reductase activity | Catalysis of the reaction: NADP(+) + sphinganine = 3-dehydrosphinganine + H(+) + NADPH. |
| heparan sulfate sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate. |
| chloride transmembrane transporter activity | Catalysis of the transfer of chloride ions from one side of a membrane to the other. |
| morphogen activity | Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient. |
| complement component c3b receptor activity | Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| monocarboxylic acid binding | Interacting selectively and non-covalently with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-). |
| organic cation transmembrane transporter activity | Catalysis of the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. |
| glucuronosyl-n-acetylglucosaminyl-proteoglycan 4-alpha-n-acetylglucosaminyltransferase activity | Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP. |
| organic hydroxy compound transmembrane transporter activity | Catalysis of the transfer of organic hydroxy compound from one side of the membrane to the other. |
| ctd phosphatase activity | Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate. |
| potassium channel inhibitor activity | Stops, prevents, or reduces the activity of a potassium channel. |
| squalene synthase activity | Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate. |
| dihydrocoumarin hydrolase activity | Catalysis of the reaction: 3,4-dihydrocoumarin + H(2)O = 3-(2-hydroxyphenyl)propanoate + H(+). |
| phosphatidyl-n-dimethylethanolamine n-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine. |
| glutaminyl-peptide cyclotransferase activity | Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3. |
| fucosidase activity | Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative. |
| asparaginase activity | Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3. |
| udp-xylosyltransferase activity | Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule. |
| gmp synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. |
| cytochrome-b5 reductase activity, acting on nad(p)h | |
| regulatory region nucleic acid binding | Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. |
| peroxidase inhibitor activity | Interacts with, and stops, prevents or reduces the activity of a peroxidase. |
| thymidylate kinase activity | Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. |
| iga binding | Interacting selectively and non-covalently with an immunoglobulin of an IgA isotype. |
| udp-n-acetylglucosamine 2-epimerase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine. |
| gaf domain binding | Interacting selectively and non-covalently with the GAF domain of a protein. |
| pyrophosphatase activity | Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments. |
| actin binding | Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. |
| endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters. |
| spermine:oxygen oxidoreductase (spermidine-forming) activity | Catalysis of the reaction: H(2)O + O(2) + spermine = 3-aminopropanal + H(2)O(2) + spermidine. |
| sulfur-containing amino acid secondary active transmembrane transporter activity | Catalysis of the transfer of sulfur-containing amino acid from one side of the membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. |
| endoplasmic reticulum signal peptide binding | Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum. |
| glucocorticoid-activated rna polymerase ii transcription factor binding transcription factor activity | Combining with a glucocorticoid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, glucocorticoid-bound receptors can bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain glucocorticoid response elements. |
| histone methyltransferase activity (h3-k36 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein. |
| glutaryl-coa dehydrogenase activity | Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor. |
| ap-2 adaptor complex binding | Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). |
| prostaglandin-i synthase activity | Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2). |
| mitogen-activated protein kinase kinase binding | Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase. |
| ubiquitin-like protein-specific isopeptidase activity | |
| dna secondary structure binding | Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions. |
| alpha-l-fucosidase activity | Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose. |
| laminin receptor activity | Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. |
| proline racemase activity | Catalysis of the reaction: L-proline = D-proline. |
| glutamate-5-semialdehyde dehydrogenase activity | Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH. |
| 3'-5' dna helicase activity | Catalysis of the unwinding of the DNA helix in the direction 3' to 5'. |
| mitochondrial ribosome binding | Interacting selectively and non-covalently with any part of a mitochondrial ribosome, a ribosome found in the mitochondrion of a eukaryotic cell. |
| transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer | Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. |
| bmp binding | Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family. |
| transferrin receptor binding | Interacting selectively and non-covalently with the transferrin receptor. |
| adp-sugar diphosphatase activity | Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate. |
| chitobiosyldiphosphodolichol beta-mannosyltransferase activity | Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol. |
| biotin-protein ligase activity | Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein. |
| neutral amino acid transmembrane transporter activity | Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7. |
| peptide-n4-(n-acetyl-beta-glucosaminyl)asparagine amidase activity | Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue. |
| galactosylgalactosylglucosylceramide beta-d-acetylgalactosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide. |
| gamma-glutamyl-peptidase activity | Catalysis of the cleavage of a gamma-linked glutamate bond. |
| lysophosphatidic acid binding | Interacting selectively and non-covalently with lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G-protein-coupled receptors. |
| acylglycerol lipase activity | Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol. |
| k6-linked polyubiquitin binding | Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 6 of the ubiquitin monomers. |
| peptidyl-dipeptidase inhibitor activity | Stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain. |
| u3 snorna binding | Interacting selectively and non-covalently with U3 small nucleolar RNA. |
| extracellular matrix binding | Interacting selectively and non-covalently with a component of the extracellular matrix. |
| norepinephrine binding | Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. |
| aspartate oxidase activity | Catalysis of the reaction: aspartate + O2 = iminosuccinate + hydrogen peroxide. |
| carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate. |
| androsterone dehydrogenase activity | Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. |
| pantetheine-phosphate adenylyltransferase activity | Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate. |
| isg15-specific protease activity | Catalysis of the hydrolysis of ISG15, a small ubiquitin-related modifier, from previously modified substrates. |
| toxin receptor binding | Interacting selectively and non-covalently with a toxin receptor, a receptor for substances that cause injury to living organisms. |
| inositol-1,3,4-trisphosphate 5-kinase activity | Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+). |
| rrna (adenine) methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine. |
| long-chain-alcohol oxidase activity | Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O. |
| laminin binding | Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells. |
| dol-p-man:man(8)glcnac(2)-pp-dol alpha-1,2-mannosyltransferase activity | Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. |
| glycine dehydrogenase (decarboxylating) activity | Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2. |
| apolipoprotein a-i receptor binding | Interacting selectively and non-covalently with an apolipoprotein A-I receptor. |
| histone kinase activity (h3-t11 specific) | Catalysis of the transfer of a phosphate group to the threonine-11 residue of the N-terminal tail of histone H3. |
| water channel activity | Transport systems of this type catalyze facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| syndecan binding | Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells. |
| protein binding involved in heterotypic cell-cell adhesion | Interacting selectively and non-covalently with any protein or protein complex contributing to the adhesion of two different types of cells. |
| interleukin-1 receptor binding | Interacting selectively and non-covalently with the interleukin-1 receptor. |
| acetyl-coa c-acyltransferase activity | Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. |
| monosaccharide binding | Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. |
| inorganic diphosphate transmembrane transporter activity | Catalysis of the transfer of inorganic diphosphate across a membrane. |
| pyruvate transmembrane transporter activity | Catalysis of the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other. |
| beta-galactoside (cmp) alpha-2,3-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R. |
| stem cell factor receptor binding | Interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor. |
| intramolecular oxidoreductase activity, transposing c=c bonds | Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears. |
| mismatched dna binding | Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. |
| protein tyrosine kinase collagen receptor activity | Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
| bile acid:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). |
| trna dimethylallyltransferase activity | Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine. |
| patched binding | Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins. |
| epidermal growth factor-activated receptor activity | Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| microsatellite binding | Interacting selectively and non-covalently with a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem. |
| inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity | Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate. |
| utp binding | Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate. |
| phosphoribosylaminoimidazolesuccinocarboxamide synthase activity | Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate. |
| nucleoside phosphate binding | Interacting selectively and non-covalently with nucleoside phosphate. |
| ribonuclease iii activity | Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. |
| interleukin-18 binding | Interacting selectively and non-covalently with interleukin-18. |
| dna ligase activity | Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+. |
| beta2-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors. |
| vascular endothelial growth factor binding | Interacting selectively and non-covalently with a vascular endothelial growth factor. |
| protein phosphorylated amino acid binding | Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein. |
| beta-galactosyl-n-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide. |
| rna polymerase binding | Interacting selectively and non-covalently with an RNA polymerase molecule or complex. |
| interleukin-8 binding | Interacting selectively and non-covalently with interleukin-8. |
| ferric-chelate reductase (nadph) activity | Catalysis of the reaction: 2 Fe3+ + NADPH = 2 Fe2+ + H+ + NADP+ . |
| dystroglycan binding | Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal). |
| melanocortin receptor binding | Interacting selectively and non-covalently with a melanocortin receptor. |
| trna (cytosine) methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine. |
| all-trans retinal binding | Interacting selectively and non-covalently with all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A. |
| phytanate-coa ligase activity | Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H(+) + phytanoyl-CoA. |
| [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity | Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate. |
| oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. |
| adp-specific glucokinase activity | Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate. |
| 6,7-dihydropteridine reductase activity | Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine. |
| translation repressor activity | Antagonizes ribosome-mediated translation of mRNA into a polypeptide. |
| l-amino acid transmembrane transporter activity | Catalysis of the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. |
| 6-phosphofructo-2-kinase activity | Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+). |
| phosphoacetylglucosamine mutase activity | Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate. |
| peptidyl-proline 3-dioxygenase activity | Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2. |
| prostaglandin-e synthase activity | Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2). |
| spermidine binding | Interacting selectively and non-covalently with spermidine, N-(3-aminopropyl)-1,4-diaminobutane. |
| 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity | Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; this reaction requires the cofactor 2,3-bisphosphoglycerate. |
| l-iditol 2-dehydrogenase activity | Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+. |
| uracil dna n-glycosylase activity | Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine. |
| sequence-specific dna binding transcription factor recruiting transcription factor activity | The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions. |
| importin-alpha export receptor activity | Interacting selectively and non-covalently with importin-alpha to mediate its transfer through the nuclear pore to the cytoplasm. |
| hydrolase activity, acting on ether bonds | Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively. |
| betaine-aldehyde dehydrogenase activity | Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+. |
| erythropoietin receptor binding | Interacting selectively and non-covalently with the erythropoietin receptor. |
| protease binding | Interacting selectively and non-covalently with any protease or peptidase. |
| 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity | Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine. |
| protein self-association | Interacting selectively and non-covalently with a domain within the same polypeptide. |
| dutp diphosphatase activity | Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| mannosyl-glycoprotein endo-beta-n-acetylglucosaminidase activity | Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. |
| cysteine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| apolipoprotein binding | Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex. |
| glutamate dehydrogenase (nad+) activity | Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+. |
| oxidoreductase activity, acting on other nitrogenous compounds as donors | Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
| rna polymerase iii transcription factor binding | Interacting selectively and non-covalently with an RNA polymerase III transcription factor, any protein required to initiate or regulate transcription by RNA polymerase III. |
| arachidonic acid binding | Interacting selectively and non-covalently with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. |
| hydroxyacid-oxoacid transhydrogenase activity | Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate. |
| a1 adenosine receptor binding | Interacting selectively and non-covalently with an A1 adenosine receptor. |
| isoleucine-trna ligase activity | Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+). |
| testosterone 17-beta-dehydrogenase (nadp+) activity | Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione. |
| acetyltransferase activity | Catalysis of the transfer of an acetyl group to an acceptor molecule. |
| 3 iron, 4 sulfur cluster binding | Interacting selectively and non-covalently with a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing. |
| ammonia-lyase activity | Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. |
| n4-(beta-n-acetylglucosaminyl)-l-asparaginase activity | Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+). |
| oxidoreductase activity, oxidizing metal ions, nad or nadp as acceptor | Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor. |
| calcium ion binding | Interacting selectively and non-covalently with calcium ions (Ca2+). |
| ciliary neurotrophic factor receptor activity | Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| carbohydrate response element binding | Interacting selectively and non-covalently with the carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes. |
| ubiquitin binding | Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
| 2 iron, 2 sulfur cluster binding | Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| structural constituent of eye lens | The action of a molecule that contributes to the structural integrity of the lens of an eye. |
| copper uptake transmembrane transporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Cu+(out) = Cu+(in). |
| interleukin-6 receptor binding | Interacting selectively and non-covalently with the interleukin-6 receptor. |
| trace-amine receptor activity | Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals. |
| aminocarboxymuconate-semialdehyde decarboxylase activity | Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2). |
| host cell surface receptor binding | Interacting selectively and non-covalently with a receptor on the host cell surface. |
| organophosphate ester transmembrane transporter activity | Catalysis of the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds. |
| taurine binding | Interacting selectively and non-covalently with taurine. |
| hormone receptor binding | Interacting selectively and non-covalently with a receptor for hormones. |
| serine binding | Interacting selectively and non-covalently with 2-amino-3-hydroxypropanoic acid. |
| l-xylulose reductase (nadp+) activity | Catalysis of the reaction: NADP(+) + xylitol = L-xylulose + H(+) + NADPH. |
| protein-disulfide reductase (glutathione) activity | Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol. |
| acetyl-coa:l-glutamate n-acetyltransferase activity | Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+). |
| alpha-1,3-mannosyltransferase activity | Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage. |
| rna polymerase ii basal transcription factor binding | Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor. |
| tryptamine:oxygen oxidoreductase (deaminating) activity | Catalysis of the reaction: tryptamine + H2O + O2 = NH3 + indole acetaldehyde + hydrogen peroxide + H+. |
| oncostatin-m receptor activity | Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| glycerol kinase activity | Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+). |
| corticotropin-releasing hormone receptor 1 binding | Interacting selectively and non-covalently with the corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system. |
| oxygen sensor activity | Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2). |
| inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity | Catalysis of the reaction: inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+. |
| cd27 receptor binding | Interacting selectively and non-covalently with a CD27, a receptor found on the surface of T cells and some B cells and NK cells. |
| minus-end directed microfilament motor activity | Catalysis of movement along a microfilament towards the minus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The minus end of an actin filament is the end that does not preferentially add actin monomers. |
| (alpha-n-acetylneuraminyl-2,3-beta-galactosyl-1,3)-n-acetyl-galactosaminide 6-alpha-sialyltransferase activity | Catalysis of the reaction: alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R + CMP-N-acetyl-beta-neuraminate = alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R + CMP. |
| calcium-dependent phospholipase c activity | Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+. |
| peptide alpha-n-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein. |
| ph domain binding | Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton. |
| neurotransmitter receptor activity | Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. |
| ubiquitin conjugating enzyme binding | Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins. |
| ccr7 chemokine receptor binding | Interacting selectively and non-covalently with a CCR7 chemokine receptor. |
| histone deacetylase inhibitor activity | Stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. |
| histone acetyltransferase activity (h4-k5 specific) | Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5). |
| glucan 1,4-alpha-glucosidase activity | Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose. |
| arachidonic acid monooxygenase activity | Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. |
| neurotrophin p75 receptor binding | Interacting selectively and non-covalently with the neurotrophin p75 receptor. |
| transketolase activity | Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor. |
| interleukin-10 receptor binding | Interacting selectively and non-covalently with the interleukin-10 receptor. |
| purine ribonucleoside triphosphate binding | Interacting selectively and non-covalently with a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar. |
| rna polymerase i core element sequence-specific dna binding | Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE. |
| mrna 3'-utr au-rich region binding | Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule. |
| protein disulfide oxidoreductase activity | Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. |
| prenylcysteine oxidase activity | Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2. |
| malonate-semialdehyde dehydrogenase (acetylating) activity | Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+. |
| calcidiol 1-monooxygenase activity | Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+). |
| formate transmembrane transporter activity | Catalysis of the transfer of formate from one side of the membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. |
| phosphatidylinositol 3-kinase catalytic subunit binding | Interacting selectively and non-covalently with the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. |
| 4 iron, 4 sulfur cluster binding | Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| dna-7-methyladenine glycosylase activity | Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site. |
| nucleobase transmembrane transporter activity | Catalysis of the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other. |
| 3-oxoacyl-[acyl-carrier-protein] synthase activity | Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. |
| ribosylnicotinamide kinase activity | Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H(+) + nicotinamide mononucleotide. |
| inorganic phosphate transmembrane transporter activity | Catalysis of the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. |
| tumor necrosis factor receptor superfamily binding | Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily. |
| ligase activity, forming phosphoric ester bonds | Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| long-chain-alcohol o-fatty-acyltransferase activity | Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA. |
| aldo-keto reductase (nadp) activity | Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. |
| delta-catenin binding | Interacting selectively and non-covalently with the delta subunit of the catenin complex. |
| inositol oxygenase activity | Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+). |
| ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. |
| cyclin-dependent protein serine/threonine kinase inhibitor activity | Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. |
| very-low-density lipoprotein particle binding | Interacting selectively and non-covalently with a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. |
| transforming growth factor beta receptor, cytoplasmic mediator activity | Activity of any of the molecules that transmit the signal from a TGF-beta receptor through the cytoplasm to the nucleus. |
| ump kinase activity | Catalysis of the reaction: ATP + UMP = ADP + UDP. |
| nad(p)+-protein-arginine adp-ribosyltransferase activity | Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine. |
| sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity | Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one. |
| amidase activity | Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3. |
| acetylesterase activity | Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate. |
| growth hormone receptor binding | Interacting selectively and non-covalently with the growth hormone receptor. |
| carbamoyl-phosphate synthase (ammonia) activity | Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate. |
| deoxycytidyl transferase activity | Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA. |
| rna polymerase iii type 3 promoter dna binding | Interacting selectively and non-covalently with a region of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III. A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae. |
| ubiquitin-like protein transferase activity | |
| creatine:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in). |
| oxidized purine nucleobase lesion dna n-glycosylase activity | Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. |
| lipase inhibitor activity | Stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. |
| sulfate transmembrane transporter activity | Catalysis of the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other. |
| mhc class i protein complex binding | Interacting selectively and non-covalently with the class I major histocompatibility complex. |
| dna polymerase processivity factor activity | An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it. |
| nerve growth factor receptor activity | Combining with nerve growth factor (NGF), to prevent apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity. |
| serine-type endopeptidase inhibitor activity | Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. |
| hla-a specific activating mhc class i receptor activity | Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte. |
| rrna (pseudouridine) methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule. |
| sulfotransferase activity | Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. |
| vasopressin receptor activity | Combining with vasopressin to initiate a change in cell activity. |
| bh3 domain binding | Interacting selectively and non-covalently with the BH3 domain of a protein of the Bcl-2 family. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death. |
| urm1 activating enzyme activity | Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond. |
| acetylcholine-activated cation-selective channel activity | Catalysis of the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine. |
| linoleic acid epoxygenase activity | Catalysis of an NADPH- and oxygen-dependent reaction that converts linoleic acid to a cis-epoxyoctadecenoic acid. |
| orotidine-5'-phosphate decarboxylase activity | Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP. |
| glyoxylate reductase (nadp) activity | Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+. |
| calcitonin receptor activity | Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| exoribonuclease ii activity | Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction. |
| mrf binding | Interacting selectively and non-covalently with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors. |
| arachidonic acid epoxygenase activity | Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid. |
| cgmp-inhibited cyclic-nucleotide phosphodiesterase activity | Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP. |
| ptb domain binding | Interacting selectively and non-covalently with a phosphotyrosine-binding (PTB) domain of a protein. |
| protein kinase inhibitor activity | Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein. |
| phosphatidylinositol-4-phosphate phosphatase activity | Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate. |
| pantetheine hydrolase activity | Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine. |
| cytosine c-5 dna demethylase activity | Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA. |
| ccr10 chemokine receptor binding | Interacting selectively and non-covalently with a CCR10 chemokine receptor. |
| palmitoyl hydrolase activity | Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate. |
| interleukin-11 receptor binding | Interacting selectively and non-covalently with the interleukin-11 receptor. |
| rab geranylgeranyltransferase activity | Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family. |
| cytidylyltransferase activity | Catalysis of the transfer of a cytidylyl group to an acceptor. |
| ceramidase activity | Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine. |
| rna polymerase ii transcription factor binding transcription factor activity | Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. |
| rho gdp-dissociation inhibitor binding | Interacting selectively and non-covalently with a Rho GDP-dissociation inhibitor protein. |
| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity | Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate. |
| methionine-trna ligase activity | Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). |
| exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. |
| histamine n-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+). |
| phenylalanine-trna ligase activity | Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). |
| transforming growth factor beta receptor activity, type ii | Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor. |
| 3-hydroxyacyl-coa dehydratase activity | Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA). |
| peptide receptor activity | Combining with an extracellular or intracellular peptide to initiate a change in cell activity. |
| dna binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| ctp synthase activity | Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. |
| purine-nucleoside phosphorylase activity | Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. |
| oxaloacetate decarboxylase activity | Catalysis of the reaction: oxaloacetate = pyruvate + CO2. |
| imp cyclohydrolase activity | Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide. |
| nedd8-specific protease activity | Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates. |
| aralkylamine n-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine. |
| acyl-coa ligase activity | Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C13 to C22. |
| palmitoyl-coa hydrolase activity | Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate. |
| oxidoreductase activity, acting on a sulfur group of donors, nad(p) as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. |
| tumor necrosis factor binding | Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages. |
| neuromedin u receptor binding | Interacting selectively and non-covalently with one or more specific sites on a neuromedin U receptor. |
| carboxypeptidase activity | Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide. |
| 5-oxoprolinase (atp-hydrolyzing) activity | Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate. |
| fucokinase activity | Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H(+). |
| hemi-methylated dna-binding | Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks. |
| ubiquitin-like protein binding | |
| serine-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| protein kinase c binding | Interacting selectively and non-covalently with protein kinase C. |
| beta-1,3-galactosyl-o-glycosyl-glycoprotein beta-1,6-n-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R. |
| histone methyltransferase activity (h3-k27 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group onto lysine at position 27 of the histone H3 protein. |
| n-sulfoglucosamine sulfohydrolase activity | Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate. |
| gonadotropin hormone-releasing hormone activity | The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary. |
| 1-phosphatidylinositol binding | Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
| pheromone binding | Interacting selectively and non-covalently with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. |
| opsin binding | Interacting selectively and non-covalently with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception. |
| lactate dehydrogenase activity | Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate. |
| s-acyltransferase activity | Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule. |
| geranylgeranyl reductase activity | Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group. |
| potassium ion transmembrane transporter activity | Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. |
| glucan 1,3-alpha-glucosidase activity | Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans. |
| voltage-gated channel activity | Catalysis of the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| iron ion transmembrane transporter activity | Catalysis of the transfer of iron (Fe) ions from one side of a membrane to the other. |
| substrate-specific transmembrane transporter activity | Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. |
| choline:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in). |
| dihydroorotate dehydrogenase activity | Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate. |
| n-acetylglucosamine 6-o-sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate. |
| rna polymerase ii core promoter sequence-specific dna binding | Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery. |
| neolactotetraosylceramide alpha-2,3-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide. |
| interleukin-3 receptor binding | Interacting selectively and non-covalently with the interleukin-3 receptor. |
| oxidoreductase activity, acting on the ch-nh group of donors, nad or nadp as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. |
| ras palmitoyltransferase activity | Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins. |
| histone pre-mrna dcp binding | Interacting selectively and non-covalently with the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing. |
| cyclic-di-gmp binding | Interacting selectively and non-covalently with cyclic-di-GMP, cyclic dimeric guanosine monophosphate. |
| orotate phosphoribosyltransferase activity | Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. |
| nicotinamide n-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine. |
| rna polymerase ii activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| zinc ion transmembrane transporter activity | Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. |
| pyridoxal phosphate binding | Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
| rac guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
| 15-hydroxyprostaglandin-d dehydrogenase (nadp+) activity | Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate. |
| deoxyribonuclease ii activity | Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products. |
| alcohol dehydrogenase (nadp+) activity | |
| fluorene oxygenase activity | Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol. |
| intracellular ligand-gated ion channel activity | Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. |
| growth factor receptor binding | Interacting selectively and non-covalently with a growth factor receptor. |
| serine-type carboxypeptidase activity | Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| 2-hydroxyglutarate dehydrogenase activity | Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. |
| [myelin basic protein]-arginine n-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine. |
| carboxyl- or carbamoyltransferase activity | Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor). |
| oligopeptide transmembrane transporter activity | Catalysis of the transfer of oligopeptides from one side of the membrane to the other. |
| pre-mrna 3'-splice site binding | Interacting selectively and non-covalently with the pre-mRNA 3' splice site sequence. |
| cysteine desulfurase activity | Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. |
| g-protein coupled pyrimidinergic nucleotide receptor activity | Combining with a pyrimidine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| pyrimidine nucleobase transmembrane transporter activity | Catalysis of the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other. |
| igg binding | Interacting selectively and non-covalently with an immunoglobulin of an IgG isotype. |
| dopamine neurotransmitter receptor activity | Combining with the neurotransmitter dopamine to initiate a change in cell activity. |
| erythropoietin receptor activity | Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| phosphoglycerate kinase activity | Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+). |
| interleukin-11 receptor activity | Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| polyribonucleotide nucleotidyltransferase activity | Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1). |
| mismatch base pair dna n-glycosylase activity | Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. |
| nucleobase-containing compound kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. |
| ras guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
| glutathione oxidoreductase activity | Catalysis of the reaction: protein-S-S-glutathione + glutathione-SH = protein-SH + glutathione-S-S-glutathione. |
| cyclosporin a binding | Interacting selectively and non-covalently with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids. |
| primary amine oxidase activity | Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. |
| activin receptor activity, type ii | Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor. |
| voltage-gated potassium channel activity involved in bundle of his cell action potential repolarization | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| phosphorus-oxygen lyase activity | Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. |
| o-octanoyltransferase activity | Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule. |
| glucosyltransferase activity | Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
| ghrelin receptor binding | Interacting selectively and non-covalently with a ghrelin receptor. |
| phosphatidic acid binding | Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. |
| peptidoglycan receptor activity | Combining with a peptidoglycan and transmitting the signal to initiate a change in cell activity. |
| adenosine receptor binding | Interacting selectively and non-covalently with an adenosine receptor. |
| canalicular bile acid transmembrane transporter activity | The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. |
| transferase activity | Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. |
| peptidyl-lysine n-acetyltransferase activity, acting on acetyl phosphate as donor | Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine. |
| gtp-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of GTP. |
| latrotoxin receptor activity | Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| (s)-limonene 6-monooxygenase activity | Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O. |
| alpha-tocopherol omega-hydroxylase activity | Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O . |
| chlordecone reductase activity | Catalysis of the reaction: chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH. |
| substance p receptor binding | Interacting selectively and non-covalently with a substance P receptor. |
| biotin carboxylase activity | Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein. |
| transferase activity, transferring acyl groups other than amino-acyl groups | Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). |
| cysteine-type carboxypeptidase activity | Catalysis of the hydrolysis of C-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| sequence-specific dna binding rna polymerase ii transcription factor activity | Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. |
| malate dehydrogenase activity | Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. |
| receptor agonist activity | Interacts with receptors such that the proportion of receptors in the active form is increased. |
| fibroblast growth factor-activated receptor activity | Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| molybdopterin molybdotransferase activity | Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP. |
| lipid kinase activity | Catalysis of the phosphorylation of a simple or complex lipid. |
| receptor tyrosine kinase-like orphan receptor binding | Interacting selectively and non-covalently with the receptor tyrosine kinase-like orphan receptor (Ror). |
| zymogen binding | Interacting selectively and non-covalently with a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis. |
| caffeine oxidase activity | Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O. |
| riboflavin transporter activity | Facilitates the directed movement of riboflavin into, out of or within a cell, or between cells. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins. |
| glucagon receptor binding | Interacting selectively and non-covalently with a glucagon receptor. |
| apolipoprotein a-i receptor activity | Combining with apolipoprotein A-I and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| farnesyltranstransferase activity | Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. |
| nucleoside deoxyribosyltransferase activity | Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1. |
| rna polymerase ii regulatory region dna binding | Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. |
| ligand-dependent nuclear receptor transcription coactivator activity | The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself. |
| s-methyltransferase activity | Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule. |
| 11-beta-hydroxysteroid dehydrogenase (nadp+) activity | |
| alpha-1,4-n-acetylgalactosaminyltransferase activity | Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage. |
| glutathione-disulfide reductase activity | Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+. |
| methylated-dna-[protein]-cysteine s-methyltransferase activity | Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. |
| sodium-dependent l-ascorbate transmembrane transporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in). |
| 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity | Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate. |
| 11-beta-hydroxysteroid dehydrogenase [nad(p)] activity | |
| rna polymerase ii distal enhancer sequence-specific dna binding transcription factor activity involved in positive regulation of transcription | Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. |
| xenobiotic-transporting atpase activity | Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out). |
| blue light photoreceptor activity | The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation. |
| chemokine activity | The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. |
| thiamine pyrophosphate binding | Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. |
| nadh dehydrogenase activity | Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. |
| structural constituent of bone | The action of a molecule that contributes to the structural integrity of bone. |
| glutamate receptor binding | Interacting selectively and non-covalently with a glutamate receptor. |
| arginine binding | Interacting selectively and non-covalently with 2-amino-5-(carbamimidamido)pentanoic acid. |
| endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. |
| butyryl-coa dehydrogenase activity | Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein. |
| transforming growth factor beta receptor, common-partner cytoplasmic mediator activity | A TGF-beta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator. The heterocomplex translocates to the nucleus to regulate transcription. |
| translation release factor activity | Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. |
| histone demethylase activity (h4-k20 specific) | Catalysis of the reaction: histone H4 N6-methyl-L-lysine (position 20) + 2-oxoglutarate + O2 = histone H4 L-lysine (position 20) + succinate + formaldehyde + CO2. This reaction is the removal of a methyl group from lysine at position 20 of the histone H4 protein. |
| glucose:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). |
| atp diphosphatase activity | Catalysis of the reaction: ATP + H2O = AMP + diphosphate. |
| inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity | Catalysis of the reaction: 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + H+. |
| 5'-nucleotidase activity | Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. |
| beta-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. |
| type 3 metabotropic glutamate receptor binding | Interacting selectively and non-covalently with a type 3 metabotropic glutamate receptor. |
| guanine phosphoribosyltransferase activity | Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate. |
| triphosphatase activity | Catalysis of the reaction: H(2)O + triphosphate = diphosphate + phosphate. |
| kinase regulator activity | Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| 1-pyrroline dehydrogenase activity | Catalysis of the reaction: 1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+. |
| organic acid binding | Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage. |
| hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances | Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group. |
| g-protein coupled nucleotide receptor activity | Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| sugar:proton symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). |
| sodium:phosphate symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in). |
| d3 dopamine receptor binding | Interacting selectively and non-covalently with a D3 dopamine receptor. |
| histone deacetylase activity | Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. |
| g-protein coupled nucleotide receptor binding | Interacting selectively and non-covalently with a G-protein coupled (metabotropic) nucleotide receptor. |
| ribonuclease mrp activity | Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA. |
| c-5 sterol desaturase activity | Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+. |
| ubiquitin-specific protease activity | Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin. |
| coproporphyrinogen oxidase activity | Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX. |
| retinol o-fatty-acyltransferase activity | Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester. |
| cyclase activator activity | Increases the activity of an enzyme that catalyzes a ring closure reaction. |
| chondroitin 6-sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate. |
| bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity | Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate. |
| hexose phosphate transmembrane transporter activity | Catalysis of the transfer of hexose phosphate from one side of the membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule. |
| peptidyl-dipeptidase activity | Catalysis of the release of C-terminal dipeptides from a polypeptide chain. |
| type i transforming growth factor beta receptor binding | Interacting selectively and non-covalently with a type I transforming growth factor beta receptor. |
| thromboxane a2 receptor activity | Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein. |
| type 5 metabotropic glutamate receptor binding | Interacting selectively and non-covalently with a type 5 metabotropic glutamate receptor. |
| gmp reductase activity | Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH. |
| inosine-diphosphatase activity | Catalysis of the reaction: IDP + H2O = IMP + phosphate. |
| procollagen-proline dioxygenase activity | Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2. |
| phosphatidylserine binding | Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. |
| structural molecule activity conferring elasticity | The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling. |
| tricarboxylic acid transmembrane transporter activity | Catalysis of the transfer of tricarboxylic acids from one side of the membrane to the other. Tricarboxylic acid are organic acids with three COOH groups. |
| phosphatidylinositol 3-kinase activity | Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring. |
| peptidase activator activity | Increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. |
| hydrolase activity, acting on ester bonds | Catalysis of the hydrolysis of any ester bond. |
| 1-acylglycerol-3-phosphate o-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. |
| aryldialkylphosphatase activity | Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol. |
| mannose-ethanolamine phosphotransferase activity | Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor. |
| polyamine transmembrane transporter activity | Catalysis of the transfer of polyamines, organic compounds containing two or more amino groups, from one side of the membrane to the other. |
| sequence-specific dna binding rna polymerase recruiting transcription factor activity | Interacting selectively and non-covalently with a specific DNA sequence and recruiting RNA polymerase to the DNA in order to form the preinitiation complex (PIC). |
| dinitrosyl-iron complex binding | Interacting selectively and non-covalently with a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO. |
| itp diphosphatase activity | Catalysis of the reaction: ITP + H2O = IMP + diphosphate. |
| oxidoreductase activity, acting on the ch-ch group of donors, quinone or related compound as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound. |
| carnosine synthase activity | Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine. |
| acetoacetate-coa ligase activity | Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H(+). |
| gdp-man:man3glcnac2-pp-dol alpha-1,2-mannosyltransferase activity | Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. |
| chromatin binding | Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| threonine-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. |
| ammonium ion binding | Interacting selectively and non-covalently with ammonium ions (NH4+). |
| neurotransmitter transporter activity | Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. |
| 4-alpha-hydroxytetrahydrobiopterin dehydratase activity | Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O. |
| d-tyrosyl-trna(tyr) deacylase activity | Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA. |
| n-methyltransferase activity | Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. |
| protoheme ix farnesyltransferase activity | Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme o + diphosphate. |
| norspermine:oxygen oxidoreductase activity | Catalysis of the reaction: norspermine + oxygen + H2O = norspermidine + 3-aminopropanal + hydrogen peroxide. |
| vitamin d 24-hydroxylase activity | Catalysis of the hydroxylation of C-24 of any form of vitamin D. |
| neuromedin b receptor binding | Interacting selectively and non-covalently with a neuromedin B receptor. |
| receptor signaling protein tyrosine kinase inhibitor activity | Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase. |
| long-chain-fatty-acyl-coa reductase activity | Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH. |
| thiamine uptake transmembrane transporter activity | Catalysis of the transfer of thiamine from the outside of a cell to the inside across a membrane. |
| poly(u) rna binding | Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule. |
| prostanoid receptor activity | Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity. |
| oxidoreductase activity, acting on a heme group of donors | Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
| quaternary ammonium group binding | Interacting selectively and non-covalently with a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. |
| arylformamidase activity | Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine. |
| bioactive lipid receptor activity | Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes. |
| steroid hormone binding | Interacting selectively and non-covalently with a steroid hormone. |
| set domain binding | Interacting selectively and non-covalently with a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation. |
| selenium binding | Interacting selectively and non-covalently with selenium (Se). |
| hexokinase activity | Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. |
| l-alanine:2-oxoglutarate aminotransferase activity | Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate. |
| purine nucleotide transmembrane transporter activity | Catalysis of the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other. |
| 5-hydroxy-6e,8z,11z,14z-icosatetraenoic acid binding | Interacting selectively and non-covalently with 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. |
| malonyl-coa decarboxylase activity | Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2. |
| cysteine dioxygenase activity | Catalysis of the reaction: L-cysteine + O(2) = 3-sulfino-L-alanine + H(+). |
| aspartate dehydrogenase activity | Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+. |
| interleukin-7 receptor binding | Interacting selectively and non-covalently with the interleukin-7 receptor. |
| cytochrome-c oxidase activity | Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with nad(p)h as one donor, and the other dehydrogenated | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and the latter donor is dehydrogenated. |
| molybdopterin-synthase sulfurtransferase activity | Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine <=> AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase. |
| mannosidase activity | Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. |
| carbohydrate kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. |
| mrna guanylyltransferase activity | Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. |
| hormone binding | Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone. |
| choline kinase activity | Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+). |
| ribonucleoside binding | Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose. |
| atp-dependent helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. |
| low voltage-gated calcium channel activity | Catalysis of the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded. |
| procollagen glucosyltransferase activity | Catalysis of the reaction: UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen. |
| tau protein binding | Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. |
| rna polymerase ii distal enhancer sequence-specific dna binding transcription factor activity | Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II. |
| urate transmembrane transporter activity | Catalysis of the transfer of urate from one side of the membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. |
| trna-specific ribonuclease activity | Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. |
| interleukin-1 binding | Interacting selectively and non-covalently with interleukin-1. |
| sodium:iodide symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in). |
| corticosterone 18-monooxygenase activity | Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O. |
| [hydroxymethylglutaryl-coa reductase (nadph)] kinase activity | Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP. |
| sphingosine-1-phosphate receptor activity | Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein. |
| exogenous lipid antigen binding | Interacting selectively and non-covalently with an exogenous lipid antigen (examples include microbial lipids and glycolipids). |
| interleukin-17 binding | Interacting selectively and non-covalently with any member of the interleukin-17 family of cytokines. |
| acetylcholine receptor activator activity | Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased. |
| type 2 galanin receptor binding | Interacting selectively and non-covalently with a type 2 galanin receptor. |
| alpha-2c adrenergic receptor binding | Interacting selectively and non-covalently with an alpha-2C adrenergic receptor. |
| alkylglycerone-phosphate synthase activity | Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion. |
| dna-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of DNA. |
| d-aspartate oxidase activity | Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide. |
| organic acid:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in). |
| succinate dehydrogenase activity | Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor. |
| dna-directed rna polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| m7g(5')pppn diphosphatase activity | Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide. |
| very long chain acyl-coa hydrolase activity | Catalysis of the reaction: H2O + a very long chain acyl-CoA = a very long chain carboxylate + CoA. A very long chain has chain length greater than C18. |
| 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding | Interacting selectively and non-covalently with the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug. |
| c-methyltransferase activity | Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule. |
| oxidoreductase activity, acting on iron-sulfur proteins as donors, nad or nadp as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP. |
| dna-directed dna polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. |
| oxysterol binding | Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol. |
| neurotrophin trk receptor binding | Interacting selectively and non-covalently with a neurotrophin TRK receptor. |
| jun kinase phosphatase activity | Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate. |
| phospholipid-translocating atpase activity | Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP. |
| beta-endorphin receptor activity | Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC). |
| cullin family protein binding | Interacting selectively and non-covalently with any member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). |
| ubiquitin-like protein ligase binding | |
| centromeric dna binding | Interacting selectively and non-covalently with a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis. |
| gpi-anchor transamidase activity | Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor. |
| unmethylated cpg binding | Interacting selectively and non-covalently with unmethylated CpG motifs. Unmethylated CpG dinucleotides are often associated with gene promoters. |
| 15-hydroxyprostaglandin dehydrogenase (nad+) activity | Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+. |
| inositol 1,3,4,5 tetrakisphosphate binding | Interacting selectively and non-covalently with inositol 1,3,4,5 tetrakisphosphate. |
| interleukin-20 binding | Interacting selectively and non-covalently with interleukin-20. |
| wd40-repeat domain binding | Interacting selectively and non-covalently with a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain. |
| glycosylphosphatidylinositol phospholipase d activity | Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol. |
| bombesin receptor activity | Combining with bombesin to initiate a change in cell activity. |
| glucose-6-phosphate dehydrogenase activity | Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. |
| carbon dioxide transmembrane transporter activity | Enables the transfer of carbon dioxide (CO2) from one side of a membrane to the other. |
| azole transporter activity | Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, into, out of or within a cell, or between cells. |
| cyclic nucleotide-gated ion channel activity | Catalysis of the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts. |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+). |
| lanosterol synthase activity | Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus. |
| cardiolipin binding | Interacting selectively and non-covalently with cardiolipin. |
| adenosylmethionine decarboxylase activity | Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2). |
| pyruvate dehydrogenase activity | Catalysis of the oxidative decarboxylation of pyruvate. |
| adenosine-phosphate deaminase activity | Catalysis of the reaction: an adenosine-phosphate + H20 = an inosine phosphate + NH3. Catalyzes the deamination of AMP, ADP or ATP. |
| phosphatidylinositol binding | Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| s-nitrosoglutathione binding | Interacting selectively and non-covalently with S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems. |
| amino acid binding | Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. |
| amidine-lyase activity | Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate. |
| gluconokinase activity | Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H(+). |
| protein phosphatase 1 binding | Interacting selectively and non-covalently with the enzyme protein phosphatase 1. |
| rna polymerase i activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| rrna (adenine-n6,n6-)-dimethyltransferase activity | Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. |
| lactase activity | Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose. |
| s-adenosyl-l-methionine transmembrane transporter activity | Catalysis of the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. |
| small gtpase regulator activity | Modulates the rate of GTP hydrolysis by a small monomeric GTPase. |
| tubulin binding | Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules. |
| phosphatase activator activity | Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. |
| transferase activity, transferring aldehyde or ketonic groups | Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor). |
| ion channel activity | Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| lipoprotein particle binding | Interacting selectively and non-covalently with a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. |
| heme-copper terminal oxidase activity | Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane. |
| oxygen-dependent protoporphyrinogen oxidase activity | Catalysis of the reaction: 3 O(2) + protoporphyrinogen IX = 3 H(2)O(2) + protoporphyrin IX. |
| steroid dehydrogenase activity | Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. |
| poly-pyrimidine tract binding | Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule. |
| proton-dependent oligopeptide secondary active transmembrane transporter activity | Catalysis of the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement. |
| inorganic anion transmembrane transporter activity | Catalysis of the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. |
| indoleamine 2,3-dioxygenase activity | Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine. |
| alpha-sialidase activity | Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids. |
| axon guidance receptor activity | Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance. |
| [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity | Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. |
| vasoactive intestinal polypeptide receptor activity | Combining with vasoactive intestinal polypeptide to initiate a change in cell activity. |
| thiolester hydrolase activity | Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. |
| succinate transmembrane transporter activity | Catalysis of the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of the membrane to the other. |
| mrna (2'-o-methyladenosine-n6-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am. |
| interleukin-5 receptor binding | Interacting selectively and non-covalently with the interleukin-5 receptor. |
| dna topoisomerase type ii (atp-hydrolyzing) activity | Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. |
| protein kinase regulator activity | Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein. |
| sulfurtransferase activity | Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). |
| calcium, potassium:sodium antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in). |
| guanylyltransferase activity | Catalysis of the transfer of a guanylyl group to an acceptor. |
| 1,5-anhydro-d-fructose reductase activity | Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH. |
| protein phosphatase regulator activity | Modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
| chemokine (c-c motif) ligand 5 binding | Interacting selectively and non-covalently with chemokine (C-C motif) ligand 5. |
| neurotrophin receptor activity | Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity. |
| oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide. |
| rna polymerase ii transcription corepressor activity | Interacting selectively and non-covalently with an RNA polymerase II repressing transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery. |
| alcohol sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate. |
| potassium:proton antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in). |
| prostaglandin receptor activity | Combining with a prostaglandin (PG) to initiate a change in cell activity. |
| 5s rrna binding | Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. |
| galactosidase activity | Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative. |
| carbohydrate derivative transporter activity | Enables the directed movement of carbohydrate derivative into, out of or within a cell, or between cells. |
| ion gated channel activity | Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus. |
| phosphatidate cytidylyltransferase activity | Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol. |
| glycine:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in). |
| damaged dna binding | Interacting selectively and non-covalently with damaged DNA. |
| biotin-[methylmalonyl-coa-carboxytransferase] ligase activity | Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase). |
| acylpyruvate hydrolase activity | Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate. |
| inositol hexakisphosphate 2-phosphatase activity | Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate. |
| thiamin-triphosphatase activity | Catalysis of the reaction: H(2)O + thiamine triphosphate = H(+) + phosphate + thiamine diphosphate. |
| tap binding | Interacting selectively and non-covalently with TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2. |
| rna polymerase ii core promoter proximal region sequence-specific dna binding | Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II. |
| phosphatidylinositol monophosphate phosphatase activity | Catalysis of the reaction: phosphatidylinositol monophosphate + H2O = phosphatidylinositol + phosphate. |
| adenosine kinase activity | Catalysis of the reaction: ATP + adenosine = ADP + AMP. |
| calcium-dependent protein kinase inhibitor activity | Stops, prevents or reduces the activity of a calcium-dependent protein kinase. |
| 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity | Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2. |
| thromboxane a2 receptor binding | Interacting selectively and non-covalently with a thromboxane A2 receptor. |
| erbb-2 class receptor binding | Interacting selectively and non-covalently with the protein-tyrosine kinase receptor Neu/ErbB-2/HER2. |
| metal ion:proton antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in). |
| nitric-oxide synthase binding | Interacting selectively and non-covalently with the enzyme nitric-oxide synthase. |
| atpase binding | Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| polynucleotide 5'-phosphatase activity | Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. |
| mhc class ii receptor activity | Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| n6-methyladenosine-containing rna binding | Interacting selectively and non-covalently with an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs. |
| very-low-density lipoprotein particle receptor activity | Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis. |
| thyroxine 5'-deiodinase activity | |
| oxidoreductase activity, acting on the ch-nh2 group of donors, disulfide as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group. |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. |
| d-dopachrome decarboxylase activity | Catalysis of the reaction: D-dopachrome + H(+) = 5,6-dihydroxyindole + CO(2). |
| 11-cis retinal binding | Interacting selectively and non-covalently with 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A. |
| adenylylsulfate kinase activity | Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate. |
| glycerophosphoinositol glycerophosphodiesterase activity | Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = sn-glycerol 3-phosphate + myo-inositol + H(+). |
| n-formylglutamate deformylase activity | Catalysis of the reaction: N-formyl-L-glutamate + H(2)O = L-glutamate + formate. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
| purine-specific nucleoside:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in). |
| inositol trisphosphate kinase activity | Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP. |
| organic acid transmembrane transporter activity | Catalysis of the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other. |
| platelet-derived growth factor beta-receptor activity | Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity. |
| adenyl-nucleotide exchange factor activity | Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. |
| corticotropin-releasing hormone receptor 2 binding | Interacting selectively and non-covalently with the corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery. |
| phosphotransferase activity, nitrogenous group as acceptor | Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor). |
| utp-activated nucleotide receptor activity | Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP. |
| oxidoreductase activity, acting on the ch-oh group of donors, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule. |
| nucleotide diphosphatase activity | Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides. |
| low-density lipoprotein particle receptor binding | Interacting selectively and non-covalently with a low-density lipoprotein receptor. |
| pattern binding | Interacting selectively and non-covalently with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan. |
| glucosidase activity | Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. |
| receptor signaling protein tyrosine kinase activity | Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
| gamma-aminobutyric acid:proton symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in). |
| nad-dependent histone deacetylase activity (h4-k16 specific) | Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein. |
| natural killer cell lectin-like receptor binding | Interacting selectively and non-covalently with a lectin-like natural killer cell receptor. |
| oligopeptide transporter activity | Enables the directed movement of oligopeptides into, out of or within a cell, or between cells. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. |
| peroxisome membrane targeting sequence binding | Interacting selectively and non-covalently with a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane. |
| alanine-trna ligase activity | Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). |
| cation binding | Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. |
| ammonia ligase activity | Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. |
| rna polymerase core enzyme binding | Interacting selectively and non-covalently with an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme. |
| insulin receptor substrate binding | Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. |
| protein-cysteine s-acyltransferase activity | Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule. |
| phospholipase d inhibitor activity | Stops, prevents or reduces the activity of a phospholipase D, an enzyme that catalyzes the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. |
| deoxyribonuclease i activity | Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products. |
| protein kinase b binding | Interacting selectively and non-covalently with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism. |
| tubulin deacetylase activity | Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate. |
| l-tyrosine aminotransferase activity | Catalysis of the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid. |
| channel inhibitor activity | Stops, prevents, or reduces the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. |
| metallochaperone activity | Assists in the delivery of metal ions to target proteins or compartments. |
| chemoattractant activity | Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. |
| protein kinase binding | Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity | Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H(2)O = 2 ADP + 2 H(+). |
| alpha-1,2-mannosyltransferase activity | Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage. |
| s-methyl-5-thioadenosine phosphorylase activity | Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate. |
| hydrogen:potassium-exchanging atpase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in). |
| peptide antigen-transporting atpase activity | Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate. |
| l-aminoadipate-semialdehyde dehydrogenase activity | Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+. |
| cp2 mannose-ethanolamine phosphotransferase activity | Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2. |
| serine-pyruvate transaminase activity | Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine. |
| hydroxymethylbilane synthase activity | Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+). |
| peptide-aspartate beta-dioxygenase activity | Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2. |
| insulin binding | Interacting selectively and non-covalently with insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. |
| g-protein beta-subunit binding | Interacting selectively and non-covalently with a G-protein beta subunit. |
| extracellular-glycine-gated ion channel activity | Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts. |
| aminoacylase activity | Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid. |
| solute:cation antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out). |
| racemase and epimerase activity, acting on carbohydrates and derivatives | Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. |
| nad-dependent histone deacetylase activity (h3-k9 specific) | Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein. |
| alpha-1,4-glucosidase activity | Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose. |
| ornithine-oxo-acid transaminase activity | Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid. |
| ep4 subtype prostaglandin e2 receptor binding | Interacting selectively and non-covalently with an EP4 subtype prostaglandin E2 receptor. |
| phosphoric diester hydrolase activity | Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. |
| sodium:inorganic phosphate symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in). |
| sodium channel activity | Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| beta3-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors. |
| nicotinate-nucleotide diphosphorylase (carboxylating) activity | Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate. |
| g-protein coupled gaba receptor activity | Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| modified amino acid transmembrane transporter activity | Catalysis of the transfer of modified amino acids from one side of a membrane to the other. |
| 4-trimethylammoniobutyraldehyde dehydrogenase activity | Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate. |
| adenylate cyclase inhibiting g-protein coupled glutamate receptor activity | Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity. |
| somatostatin receptor activity | Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G-protein coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28). |
| nad-dependent protein deacetylase activity | Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD. |
| calcium-transporting atpase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). |
| transferase activity, transferring alkyl or aryl (other than methyl) groups | Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). |
| beta-endorphin binding | Interacting selectively and non-covalently with beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin. |
| coa-transferase activity | Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor). |
| acid-sensing ion channel activity | Catalysis of the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when a an extracellular proton has been bound by the channel complex. |
| aconitate decarboxylase activity | Catalysis of the reaction: cis-aconitate + H(+) = CO(2) + itaconate. |
| cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity | Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one. |
| u2 snrna binding | Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA). |
| lipid transporter activity | Enables the directed movement of lipids into, out of or within a cell, or between cells. |
| r-smad binding | Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein. |
| plus-end directed microfilament motor activity | Catalysis of movement along a microfilament towards the plus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The plus end of an actin filament is the end that preferentially adds actin monomers. |
| pre-mirna binding | Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA. |
| dipeptidase activity | Catalysis of the hydrolysis of a dipeptide. |
| interleukin-17 receptor activity | Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| glycolipid transporter activity | Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells. |
| 18s rrna (adenine(1779)-n(6)/adenine(1780)-n(6))-dimethyltransferase activity | Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA. |
| hypoxanthine phosphoribosyltransferase activity | Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. |
| g-protein coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| olfactory receptor binding | Interacting selectively and non-covalently with an olfactory receptor. |
| ribose-5-phosphate isomerase activity | Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate. |
| hepoxilin-epoxide hydrolase activity | Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate. |
| acireductone dioxygenase [iron(ii)-requiring] activity | Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate + H(+). |
| ufm1 activating enzyme activity | Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond. |
| glycine n-benzoyltransferase activity | Catalysis of the reaction: benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+). |
| hyaluronan synthase activity | Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP. |
| ceramide cholinephosphotransferase activity | Catalysis of the reaction: CDP-choline + ceramide = CMP + H(+) + sphingomyelin. |
| tat protein binding | Interacting selectively and non-covalently with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus. |
| phosphorylase activity | Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. |
| saccharopine dehydrogenase activity | Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor. |
| 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity | Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. |
| sequence-specific dna binding | Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| extracellular matrix structural constituent | The action of a molecule that contributes to the structural integrity of the extracellular matrix. |
| interleukin-7 receptor activity | Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| trna (cytosine-5-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine. |
| low-affinity phosphate transmembrane transporter activity | Catalysis of the transfer of phosphate from one side of the membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. |
| g-protein gamma-subunit binding | Interacting selectively and non-covalently with a G-protein gamma subunit. |
| glycerate kinase activity | Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H(+). |
| arachidonate 5-lipoxygenase activity | Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate. |
| l-ascorbate:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ascorbate(out) + Na+(out) = ascorbate(in) + Na+(in). |
| peptidyl-lysine 5-dioxygenase activity | Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2. |
| polysaccharide binding | Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. |
| angiostatin binding | Interacting selectively and non-covalently with angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis. |
| sphingomyelin synthase activity | Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin. |
| phosphoribosylaminoimidazolecarboxamide formyltransferase activity | Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide. |
| inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity | Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate. |
| glutathione transferase activity | Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. |
| deoxyribonucleotide binding | Interacting selectively and non-covalently with a deoxyribonucleotide, any compound consisting of a deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety. |
| oxidative phosphorylation uncoupler activity | Catalysis of the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis. |
| nuclear localization sequence binding | Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. |
| inositol-1,4,5-trisphosphate 5-phosphatase activity | Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate. |
| steroid binding | Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. |
| 2-methylcitrate dehydratase activity | Catalysis of the reaction: (2S,3S)-2-methylcitrate = cis-2-methylaconitate + H(2)O. |
| angiotensin type i receptor activity | An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms. |
| amine-lyase activity | Catalysis of the release of amides by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate. |
| atg8 ligase activity | Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 to substrate molecules; phosphatidylethanolamine is a known substrate. |
| glycerol-3-phosphate dehydrogenase [nad+] activity | Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. |
| phosphodiesterase i activity | Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides. |
| 6-phosphogluconolactonase activity | Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+). |
| pyrimidine nucleoside binding | Interacting selectively and non-covalently with a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose. |
| endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. |
| serine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| dynorphin receptor activity | Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin. |
| oxidoreductase activity, acting on nad(p)h, nad(p) as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
| purine deoxyribonucleotide binding | Interacting selectively and non-covalently with a purine deoxyribonucleotide, any compound consisting of a purine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety. |
| imp dehydrogenase activity | Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+. |
| oxidoreductase activity, oxidizing metal ions, oxygen as acceptor | Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor. |
| dbd domain binding | Interacting selectively and non-covalently with the DBD, DNA binding domain, of a protein. The DNA binding domain of the vitamin D receptor, one of a family of receptors with the DBD, is split into three regions, the P, D and T boxes. Residues that are critical for target sequence selectivity form the P-box. The D-box contains residues that are important for homodimerization of class I nuclear receptors. The T-box is essential for both DNA-binding and transactivation of the VDR; this region may also be important for dimerization with RXR for class II nuclear receptors. |
| peptide-methionine (s)-s-oxide reductase activity | Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. |
| oxidoreductase activity, acting on the ch-nh group of donors, flavin as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin. |
| ephrin receptor activity | Combining with an ephrin to initiate a change in cell activity. |
| phosphatidylinositol-3-phosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. |
| fructose-2,6-bisphosphate 2-phosphatase activity | Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate. |
| amide binding | Interacting selectively and non-covalently with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. |
| peptide deformylase activity | Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide. |
| pseudouridine synthase activity | Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. |
| profilin binding | Interacting selectively and non-covalently with profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin. |
| g-protein coupled receptor binding | Interacting selectively and non-covalently with a G-protein coupled receptor. |
| histone methyltransferase activity (h3-k4 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein. |
| guanylate cyclase activator activity | Increases the activity of guanylate cyclase. |
| tocotrienol omega-hydroxylase activity | Catalysis of the reaction: tocotrienol + O2 + NADPH + H+ = 13'-hydroxy-tocotrienol + NADP+ + H2O . |
| rrna methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. |
| (s)-2-(5-amino-1-(5-phospho-d-ribosyl)imidazole-4-carboxamido)succinate amp-lyase (fumarate-forming) activity | Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. |
| phosphatidylinositol-3,5-bisphosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions. |
| histone demethylase activity (h3-monomethyl-k4 specific) | Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 4) + O2 + FAD + H2O = histone H3 L-lysine (position 4) + H2O2 + formaldehyde + FADH2. This reaction is the removal of a methyl group from monomethylated lysine at position 4 of the histone H3 protein. |
| calcium-transporting atpase activity involved in regulation of cardiac muscle cell membrane potential | Catalysis of the transfer of a solute or solutes from one side of a cardiac muscle cell plasma membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). The transfer contributes to the regulation of the plasma membrane potential. |
| glycerophosphodiester phosphodiesterase activity | Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. |
| malate dehydrogenase (decarboxylating) (nad+) activity | Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. |
| cyclin binding | Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. |
| procollagen-proline 4-dioxygenase activity | Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2. |
| protein carboxyl o-methyltransferase activity | Catalysis of the transfer of a methyl group to a carboxyl group on a protein. |
| ligand-gated ion channel activity | Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
| interleukin-2 binding | Interacting selectively and non-covalently with interleukin-2. |
| phosphatidylcholine-sterol o-acyltransferase activity | Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine. |
| dna topoisomerase binding | Interacting selectively and non-covalently with a DNA topoisomerase. |
| inositol-hexakisphosphate phosphatase activity | Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate. |
| methionine adenosyltransferase regulator activity | Modulates the activity of methionine adenosyltransferase. |
| inositol-3,4,6-trisphosphate 1-kinase activity | Catalysis of the reaction: 1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+). |
| androsterone dehydrogenase (b-specific) activity | Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+. |
| high molecular weight b cell growth factor receptor binding | Interacting selectively and non-covalently with the high molecular weight B cell growth factor receptor. |
| inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity | Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+. |
| metal cluster binding | Interacting selectively and non-covalently with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters. |
| carbohydrate phosphatase activity | Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate. |
| benzaldehyde dehydrogenase activity | Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+. |
| crossover junction endodeoxyribonuclease activity | Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). |
| myosin phosphatase regulator activity | Modulation of the activity of the enzyme myosin phosphatase. |
| endodeoxyribonuclease activity | Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. |
| glutamate decarboxylase activity | Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. |
| rna polymerase iii type 1 promoter dna binding | Interacting selectively and non-covalently with a region of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition. |
| atp-dependent 5'-3' rna helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 5' to 3'. |
| queuine trna-ribosyltransferase activity | Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine. |
| retinol binding | Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. |
| tetrahydrofolylpolyglutamate synthase activity | Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). |
| enzyme regulator activity | Binds to and modulates the activity of an enzyme. |
| deoxyribodipyrimidine photo-lyase activity | Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light. |
| adp-ribosylarginine hydrolase activity | Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose. |
| inositol hexakisphosphate 3-kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate. |
| prolactin receptor binding | Interacting selectively and non-covalently with the prolactin receptor. |
| fad transmembrane transporter activity | Enables the directed movement of flavin-adenine dinucleotide (FAD) across a membrane into, out of or within a cell, or between cells. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form. |
| inositol trisphosphate phosphatase activity | Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate. |
| 1-alkenylglycerophosphoethanolamine o-acyltransferase activity | Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA. |
| enone reductase activity | Catalysis of the reaction: an enone + NADPH + H+ = a ketone + NADP+. |
| enoyl-[acyl-carrier-protein] reductase (nadph, b-specific) activity | Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+. |
| arf guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
| sodium ion binding | Interacting selectively and non-covalently with sodium ions (Na+). |
| galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity | Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein. |
| 2,4-dienoyl-coa reductase (nadph) activity | Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+. |
| coa carboxylase activity | Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| oxoglutarate dehydrogenase (succinyl-transferring) activity | Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2. |
| peptide hormone binding | Interacting selectively and non-covalently with any peptide with hormonal activity in animals. |
| transmembrane-ephrin receptor activity | Combining with a transmembrane ephrin to initiate a change in cell activity. |
| l-cystine transmembrane transporter activity | Catalysis of the transfer of L-cystine from one side of a membrane to the other. |
| flavonol 3-sulfotransferase activity | Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H(+) + quercetin 3-sulfate. |
| kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| mhc class ii protein complex binding | Interacting selectively and non-covalently with the class II major histocompatibility complex. |
| chemokine receptor activity | Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. |
| protein-arginine omega-n symmetric methyltransferase activity | Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues. |
| sphingosine hydroxylase activity | Catalysis of the hydroxylation of sphingolipid long chain bases. |
| d-erythro-sphingosine kinase activity | Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP. |
| anaphase-promoting complex binding | Interacting selectively and non-covalently with an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. |
| tubulin-glutamic acid ligase activity | Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule. |
| lipoteichoic acid binding | Interacting selectively and non-covalently with lipoteichoic acid. |
| gaba-a receptor activity | Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels. |
| complement receptor activity | Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| tyrosyl-rna phosphodiesterase activity | Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis. |
| oxygen transporter activity | Enables the directed movement of oxygen into, out of or within a cell, or between cells. |
| acyl-coa hydrolase activity | Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. |
| death effector domain binding | Interacting selectively and non-covalently with a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD). |
| ligase activity | Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| sodium:potassium-exchanging atpase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). |
| polyol transmembrane transporter activity | Catalysis of the transfer of a polyol from one side of the membrane to the other. A polyol is any polyhydric alcohol. |
| cysteinyl leukotriene receptor activity | Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine. |
| ligand-gated channel activity | Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
| polyprenyltransferase activity | Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor). |
| succinate-semialdehyde dehydrogenase [nad(p)+] activity | |
| methionine synthase activity | Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine. |
| cyclase activity | Catalysis of a ring closure reaction. |
| n-formyl peptide receptor activity | Combining with an N-formyl peptide to initiate a change in cell activity. |
| tir domain binding | Interacting selectively and non-covalently with a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. |
| voltage-gated anion channel activity | Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| serine-type exopeptidase activity | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| acid phosphatase activity | Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. |
| calcitonin family receptor activity | Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity. |
| 8-oxo-dgdp phosphatase activity | Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate. |
| deoxyguanosine kinase activity | Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+). |
| cation:sugar symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in). |
| metalloendopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| iron ion binding | Interacting selectively and non-covalently with iron (Fe) ions. |
| peptidase activity | Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. |
| nucleotide receptor activity | Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. |
| insulin-like growth factor ii binding | Interacting selectively and non-covalently with insulin-like growth factor II. |
| xtp binding | Interacting selectively and non-covalently with XTP. |
| hydrogen ion transmembrane transporter activity | Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. |
| didp diphosphatase activity | Catalysis of the reaction: dIDP + H2O = dIMP + phosphate. |
| ubiquitin conjugating enzyme activity | Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. |
| c-c chemokine binding | Interacting selectively and non-covalently with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. |
| hypocretin receptor binding | Interacting selectively and non-covalently with the hypocretin receptor. |
| lactose binding | Interacting selectively and non-covalently with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk. |
| dihydrolipoamide s-acyltransferase activity | Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide. |
| phospholipid-hydroperoxide glutathione peroxidase activity | Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione. |
| methionyl-trna formyltransferase activity | Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA. |
| c3hc4-type ring finger domain binding | Interacting selectively and non-covalently with a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway. |
| homocysteine desulfhydrase activity | Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate. |
| 1-aminocyclopropane-1-carboxylate synthase activity | Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+). |
| interferon-gamma receptor activity | Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| ligand-dependent nuclear receptor binding | Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein. |
| 3',5'-cyclic-gmp phosphodiesterase activity | Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. |
| chloride channel inhibitor activity | Stops, prevents, or reduces the activity of a chloride channel. |
| acetylcholinesterase activity | Catalysis of the reaction: acetylcholine + H2O = choline + acetate. |
| peptidase inhibitor activity | Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. |
| trna (m5u54) methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule. |
| ferroxidase activity | Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O. |
| parathyroid hormone receptor binding | Interacting selectively and non-covalently with a parathyroid hormone receptor. |
| protein binding transcription factor activity | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. |
| steroid 21-monooxygenase activity | Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O. |
| pre-mrna binding | Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. |
| mhc class ii protein binding, via antigen binding groove | Interacting selectively and non-covalently with the antigen binding groove of major histocompatibility complex class II molecules. |
| dopamine transmembrane transporter activity | Catalysis of the transfer of dopamine from one side of the membrane to the other. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. |
| protein-arginine omega-n monomethyltransferase activity | Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. |
| intramolecular oxidoreductase activity, transposing s-s bonds | Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears. |
| ran gtpase binding | Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly. |
| interleukin-12 beta subunit binding | Interacting selectively and non-covalently with the beta subunit of interleukin-12. |
| rna polymerase ii activating transcription factor binding | Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription. |
| cadmium ion binding | Interacting selectively and non-covalently with cadmium (Cd) ions. |
| 8-oxo-7,8-dihydroguanine dna n-glycosylase activity | Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. |
| cysteine-s-conjugate n-acetyltransferase activity | Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H(+). |
| phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | Catalysis of the reaction: phosphatidylinositol-3,4-bisphosphate + H2O = phosphatidylinositol-4-phosphate + phosphate. |
| acetyl-coa c-acetyltransferase activity | Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA. |
| ketohexokinase activity | Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate. |
| nicotinamide phosphoribosyltransferase activity | Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide. |
| cyclic-nucleotide phosphodiesterase activity | Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. |
| taste receptor binding | Interacting selectively and non-covalently with a taste receptor. |
| methenyltetrahydrofolate cyclohydrolase activity | Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. |
| bis(5'-adenosyl)-triphosphatase activity | Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP + 2 H(+). |
| nad(p)+ transhydrogenase activity | Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. |
| rna polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template. |
| 5'-3' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. |
| l-cysteine:2-oxoglutarate aminotransferase activity | Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate. |
| phenylalanine 4-monooxygenase activity | Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin. |
| ige binding | Interacting selectively and non-covalently with an immunoglobulin of the IgE isotype. |
| interleukin-1, type i receptor binding | Interacting selectively and non-covalently with a Type I interleukin-1 receptor. |
| sodium channel regulator activity | Modulates the activity of a sodium channel. |
| n-succinyltransferase activity | Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule. |
| mutlalpha complex binding | Interacting selectively and non-covalently with the mismatch repair complex MutLalpha. |
| dopamine binding | Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. |
| rna binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
| oxidoreductase activity, acting on nad(p)h, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. |
| d-amino-acid oxidase activity | Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide. |
| troponin t binding | Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex. |
| 1-alkenylglycerophosphocholine o-acyltransferase activity | Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA. |
| proteoglycan binding | Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans. |
| interleukin-27 receptor activity | Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| oxidoreductase activity, oxidizing metal ions | Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. |
| nadph:sulfur oxidoreductase activity | Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+. |
| ganglioside galactosyltransferase activity | Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine. |
| cell adhesive protein binding involved in bundle of his cell-purkinje myocyte communication | Interacting selectively and non-covalently with any protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells. |
| potassium ion antiporter activity | Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
| second spliceosomal transesterification activity | Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. |
| udp-n-acetylglucosamine-lysosomal-enzyme n-acetylglucosaminephosphotransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose. |
| mechanically-gated ion channel activity | Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress. |
| d5 dopamine receptor binding | Interacting selectively and non-covalently with a D5 dopamine receptor. |
| 2'-5'-oligoadenylate synthetase activity | Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA. |
| coreceptor activity involved in wnt signaling pathway | In cooperation with a primary Wnt receptor, initiating a change in cell activity through the Wnt signaling pathway. |
| long-chain-(s)-2-hydroxy-long-chain-acid oxidase activity | Catalysis of the reaction: long-chain-(S)-2-hydroxy-acid + O2 = long-chain-2-oxo acid + hydrogen peroxide. Long chain refers to a chain length of 14 to 18 carbons. |
| disaccharide binding | Interacting selectively and non-covalently with any disaccharide. Disaccharides are sugars composed of two monosaccharide units. |
| atg12 activating enzyme activity | Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond. |
| telomerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. |
| triglyceride binding | Interacting selectively and non-covalently with any triester of glycerol. |
| acetylserotonin o-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine. |
| estradiol 17-beta-dehydrogenase activity | Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. |
| oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen. |
| nad-dependent histone deacetylase activity | Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone. |
| efflux transmembrane transporter activity | Catalysis of the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. |
| inositol-1,3,4,5,6-pentakisphosphate kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown. |
| ccr5 chemokine receptor binding | Interacting selectively and non-covalently with a CCR5 chemokine receptor. |
| receptor activity | Combining with an extracellular or intracellular messenger to initiate a change in cell activity. |
| tropomyosin binding | Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. |
| interleukin-22 receptor activity | Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| malate dehydrogenase (decarboxylating) (nadp+) activity | Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. |
| phosphopyruvate hydratase activity | Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. |
| 3'-5'-exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule. |
| holo-[acyl-carrier-protein] synthase activity | Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. |
| actin-dependent atpase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate. |
| 3-hydroxyisobutyryl-coa hydrolase activity | Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate. |
| arsenate reductase (glutaredoxin) activity | Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. |
| amp-activated protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP. |
| cystathionine gamma-lyase activity | Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+. |
| ferritin receptor activity | Combining with ferritin, and delivering ferritin into the cell via endocytosis. |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides | Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide. |
| malate transmembrane transporter activity | Catalysis of the transfer of malate from one side of the membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. |
| dcmp deaminase activity | Catalysis of the reaction: dCMP + H2O = dUMP + NH3. |
| transforming growth factor beta receptor activity, type i | Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals. |
| drug binding | Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. |
| diacyl lipopeptide binding | Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of two acyl groups. |
| integrin binding involved in cell-matrix adhesion | Any integrin binding that occurs as part of the process of cell-matrix adhesion. |
| connexin binding | Interacting selectively and non-covalently with a connexin, any of a group of related proteins that assemble to form gap junctions. |
| protein c-terminal carboxyl o-methyltransferase activity | Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein. |
| signal recognition particle binding | Interacting selectively and non-covalently with the signal recognition particle. |
| 3-phosphoinositide-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a phosphatidylinositol-3-phosphate. |
| protein kinase activator activity | Increases the activity of a protein kinase, an enzyme which phosphorylates a protein. |
| strictosidine synthase activity | Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine. |
| nickel cation binding | Interacting selectively and non-covalently with nickel (Ni) cations. |
| sulfuric ester hydrolase activity | Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2. |
| acyloxyacyl hydrolase activity | Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid. |
| lysine-trna ligase activity | Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). |
| gap junction channel activity involved in cell communication by electrical coupling | |
| spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity | Catalysis of the reaction: H(2)O + O(2) + spermidine = 3-aminopropanal + H(2)O(2) + putrescine. |
| titin z domain binding | Interacting selectively and non-covalently with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34. |
| cytidylate kinase activity | Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP. |
| double-stranded dna-dependent atpase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of double-stranded DNA, and it drives another reaction. |
| cobalt ion transmembrane transporter activity | Catalysis of the transfer of cobalt (Co) ions from one side of a membrane to the other. |
| uroporphyrinogen-iii synthase activity | Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III. |
| gq/11-coupled serotonin receptor activity | Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels. |
| rage receptor binding | Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products. |
| uroporphyrinogen decarboxylase activity | Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. |
| oxidoreductase activity, acting on ch or ch2 groups, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. |
| mitochondrial heavy strand promoter sense binding | Interacting selectively and non-covalently with the sense strand of the heavy strand promoter, a promoter located on the heavy, or guanine-rich, strand of mitochondrial DNA. |
| interleukin-33 binding | Interacting selectively and non-covalently with interleukin-33. |
| double-stranded methylated dna binding | Interacting selectively and non-covalently with double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks. |
| intracellular cgmp activated cation channel activity | Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts. |
| protein-n-terminal asparagine amidohydrolase activity | Catalysis of the reaction: protein-L-asparagine + H2O = protein-L-aspartate + NH3. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein. |
| udp-glucose:glycoprotein glucosyltransferase activity | Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins. |
| sphingolipid transporter activity | Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). |
| oxidoreductase activity, acting on ch-oh group of donors | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
| polydeoxyribonucleotide kinase activity | Catalysis of the reaction: NTP + 5'-dephospho-DNA = NDP + 5'-phospho-DNA. |
| rna polymerase ii distal enhancer sequence-specific dna binding | Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter. |
| lipase activity | Catalysis of the hydrolysis of a lipid or phospholipid. |
| oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a cytochrome. |
| guanyl deoxyribonucleotide binding | Interacting selectively and non-covalently with a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety. |
| nuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids. |
| calcium-dependent atpase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+). |
| rna ligase activity | Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the 5'-phosphate group at the end of another. |
| transforming growth factor beta binding | Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. |
| amidophosphoribosyltransferase activity | Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O. |
| trna (guanine) methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine. |
| mannose binding | Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. |
| iodide peroxidase activity | Catalysis of the reaction: iodide + hydrogen peroxide = iodine + 2 H2O. |
| oxidative rna demethylase activity | Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. |
| lithocholic acid binding | Interacting selectively and non-covalently with lithocholic acid. |
| dolichyldiphosphatase activity | Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate. |
| all-trans-retinol 13,14-reductase activity | Catalysis of the reaction: all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH(2). Note that this reaction has only been observed to occur in the opposite direction. |
| polynucleotide 3'-phosphatase activity | Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage. |
| isovaleryl-coa dehydrogenase activity | Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF. |
| complement component c5a binding | Interacting selectively and non-covalently with the C5a product of the complement cascade. |
| thiopurine s-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. |
| adenine nucleotide transmembrane transporter activity | Catalysis of the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of the membrane to the other. |
| fmn binding | Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. |
| af-1 domain binding | Interacting selectively and non-covalently with the AF-1 domain of a protein, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor. |
| thioredoxin peroxidase activity | Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O. |
| acetate-coa ligase activity | Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. |
| purine nucleotide binding | Interacting selectively and non-covalently with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate. |
| ribonucleotide binding | Interacting selectively and non-covalently with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. |
| chemokine binding | Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. |
| testosterone 6-beta-hydroxylase activity | Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O. |
| geranyltranstransferase activity | Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate. |
| glial cell-derived neurotrophic factor receptor activity | Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| oxidative dna demethylase activity | Catalysis of the removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. |
| leucine binding | Interacting selectively and non-covalently with 2-amino-4-methylpentanoic acid. |
| reelin receptor activity | Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| transmembrane transporter activity | Enables the transfer of a substance from one side of a membrane to the other. |
| inositol pentakisphosphate 2-kinase activity | Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H(+). |
| lipopolysaccharide binding | Interacting selectively and non-covalently with lipopolysaccharide. |
| palmitoyltransferase activity | Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. |
| pyruvate dehydrogenase (acetyl-transferring) kinase activity | Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. |
| thioredoxin-disulfide reductase activity | Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide. |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles | Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN. |
| aldehyde dehydrogenase [nad(p)+] activity | |
| sulfate binding | Interacting selectively and non-covalently with sulfate, SO4(2-), a negatively charged small molecule. |
| retinal binding | Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. |
| rna polymerase ii core promoter proximal region sequence-specific dna binding transcription factor activity involved in negative regulation of transcription | Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| immunoglobulin receptor binding | Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule. |
| transferase activity, transferring amino-acyl groups | Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor). |
| beta-n-acetylhexosaminidase activity | Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. |
| heparanase activity | Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains. |
| l-iduronidase activity | Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate. |
| 1-alkylglycerophosphocholine o-acyltransferase activity | Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA. |
| starch binding | Interacting selectively and non-covalently with starch. |
| cytokine activity | Functions to control the survival, growth, differentiation and effector function of tissues and cells. |
| deaminated base dna n-glycosylase activity | DNA N-glycosylase activity acting on deaminated bases. |
| rna-dna hybrid ribonuclease activity | Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. |
| triacyl lipopeptide binding | Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of three acyl groups. |
| group ii metabotropic glutamate receptor activity | A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity. |
| neuropilin binding | Interacting selectively and non-covalently with a member of the neuropilin family. |
| aminoacyl-trna hydrolase activity | Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. |
| protein kinase c activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. |
| hyaluronoglucuronidase activity | Catalysis of the random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate. |
| poly-adp-d-ribose binding | Interacting selectively and non-covalently with polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring. |
| saccharopine dehydrogenase (nadp+, l-lysine-forming) activity | Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = 2-oxoglutarate + L-lysine + H(+) + NADPH. |
| rna polymerase i core binding | Interacting selectively and non-covalently with RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits. |
| dna topoisomerase ii activity | Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; changes the linking number in multiples of 2. |
| acidic amino acid transmembrane transporter activity | Catalysis of the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7. |
| rna guanylyltransferase activity | Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule. |
| estrogen response element binding | Interacting selectively and non-covalently with the estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen. |
| beta-2-microglobulin binding | Interacting selectively and non-covalently with beta-2-microglobulin. |
| nuclear export signal receptor activity | Combining with a nuclear export signal (NES) to mediate transport of the NES-containing protein through the nuclear pore to the cytoplasm. |
| bis(5'-nucleosyl)-tetraphosphatase activity | Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides. |
| excitatory extracellular ligand-gated ion channel activity | Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular excitatory ligand has been bound by the channel complex or one of its constituent parts. Excitatory ligands, such as acetylcholine or glutamate, open cation-selective channels. |
| protein-l-isoaspartate (d-aspartate) o-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. |
| interleukin-33 receptor activity | Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| ornithine decarboxylase regulator activity | Modulation of the activity of the enzyme ornithine decarboxylase. |
| pattern recognition receptor activity | Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), to initiate a change in cell activity. |
| histone deacetylase binding | Interacting selectively and non-covalently with the enzyme histone deacetylase. |
| phosphoenolpyruvate carboxykinase (gtp) activity | Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2. |
| alkali metal ion binding | Interacting selectively and non-covalently with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen. |
| mono-olein transacylation activity | Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol. |
| rna polymerase ii transcription factor binding transcription factor activity involved in negative regulation of transcription | Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. |
| inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity | Catalysis of the reaction: inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+. |
| rna polymerase i transcription factor binding transcription factor activity | Interacting selectively and non-covalently with an RNA polymerase I transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. |
| cysteine-type endopeptidase activity involved in apoptotic process | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process. |
| molybdopterin-synthase adenylyltransferase activity | Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP. |
| phospholipase a2 activator activity | Increases the activity of the enzyme phospholipase A2. |
| glycerate dehydrogenase activity | Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+. |
| metalloexopeptidase activity | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| phosphomannomutase activity | Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate. |
| dead/h-box rna helicase binding | Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase. |
| intramolecular oxidoreductase activity, interconverting keto- and enol-groups | Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears. |
| interleukin-20 receptor binding | Interacting selectively and non-covalently with the interleukin-20 receptor. |
| fumarylpyruvate hydrolase activity | Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+. |
| very-long-chain-acyl-coa dehydrogenase activity | Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22. |
| ceramide glucosyltransferase activity | Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine. |
| mh1 domain binding | Interacting selectively and non-covalently with the MH1 (MAD homology 1) domain of a protein. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors. |
| interleukin-12 binding | Interacting selectively and non-covalently with interleukin-12. |
| nucleoside triphosphate adenylate kinase activity | Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP. |
| gated channel activity | Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus. |
| alpha-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors. |
| acyl carnitine transmembrane transporter activity | Enables the directed movement of acyl carnitine across a membrane. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane. |
| peptidyl-proline 4-dioxygenase activity | Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2. |
| guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity | Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate. |
| u6 snrna 3'-end binding | Interacting selectively and non-covalently with the 3' end of the U6 small nuclear RNA (U6 snRNA). |
| 3'-phosphoadenosine 5'-phosphosulfate binding | Interacting selectively and non-covalently with 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. |
| phospholipase c activity | Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. |
| monocarboxylic acid transmembrane transporter activity | Catalysis of the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. |
| phospholipase binding | Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid. |
| inositol diphosphate pentakisphosphate diphosphatase activity | Catalysis of the reaction: inositol diphosphate pentakisphosphate + H2O = inositol hexakisphosphate + phosphate. |
| rna transmembrane transporter activity | Catalysis of the transfer of RNA, ribonucleic acid, from one side of a membrane to the other. |
| divalent inorganic cation transmembrane transporter activity | Catalysis of the transfer of inorganic cations with a valency of two from one side of the membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. |
| vitamin d3 25-hydroxylase activity | Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O. |
| bmp receptor binding | Interacting selectively and non-covalently with a BMP receptor. |
| vegf-b-activated receptor activity | Combining with vascular endothelial growth factor B (VEGF-B) and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| glycoprotein transporter activity | Enables the directed movement of a glycoprotein, any protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells. |
| oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen. |
| dihydropyrimidinase activity | Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate. |
| inositol-3-phosphate synthase activity | Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form. |
| serotonin transmembrane transporter activity | Catalysis of the transfer of serotonin from one side of the membrane to the other. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. |
| mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). |
| ap-1 adaptor complex binding | Interacting selectively and non-covalently with the AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). |
| lactose synthase activity | Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose. |
| steroid 17-alpha-monooxygenase activity | Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. |
| monovalent anion:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent anion(out) + Na+(out) = monovalent anion(in) + Na+(in). |
| death domain binding | Interacting selectively and non-covalently with a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB. |
| peptide hormone receptor binding | Interacting selectively and non-covalently with a receptor for peptide hormones. |
| trans-l-3-hydroxyproline dehydratase activity | Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H(2)O + H(+). |
| heat shock protein binding | Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock. |
| xylosylprotein 4-beta-galactosyltransferase activity | Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein. |
| nad+ kinase activity | Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+). |
| palmitoyl-coa oxidase activity | Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide. |
| protein-n-terminal glutamine amidohydrolase activity | Catalysis of the reaction: protein-N-terminal-L-glutamine + H2O = protein-N-terminal-L-glutamate + NH3. This reaction is the deamidation of an N-terminal glutamine residue of a protein. |
| rab gdp-dissociation inhibitor activity | Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. |
| protein phosphatase type 2a regulator activity | Modulation of the activity of the enzyme protein phosphatase type 2A. |
| fructose 1,6-bisphosphate 1-phosphatase activity | Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. |
| acetylcholine receptor binding | Interacting selectively and non-covalently with an acetylcholine receptor. |
| helicase activity | Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix. |
| oxidoreductase activity, acting on a sulfur group of donors | Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
| recombinase activity | Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. |
| rna polymerase ii core binding | Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. |
| phosphatidic acid transporter activity | Enables the directed movement of phosphatidic acid into, out of or within a cell, or between cells. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3. |
| 4-hydroxyphenylpyruvate dioxygenase activity | Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. |
| ubiquinol-cytochrome-c reductase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. |
| protein-arginine omega-n asymmetric methyltransferase activity | Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues. |
| aromatic-l-amino-acid decarboxylase activity | Catalysis of the reaction: L-amino acid + H+ = R-H + CO2. |
| interleukin-3 receptor activity | Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| high-affinity inorganic phosphate:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. |
| sugar-phosphatase activity | Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate. |
| voltage-gated sodium channel activity involved in purkinje myocyte action potential | Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| protein o-glcnac transferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine. |
| myristoyltransferase activity | Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule. |
| cysteine-type exopeptidase activity | Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| (s)-limonene 7-monooxygenase activity | Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (4S)-perillyl alcohol + H(2)O + NADP(+). |
| interleukin-12 receptor activity | Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| cd8 receptor binding | Interacting selectively and non-covalently with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes. |
| transforming growth factor beta receptor binding | Interacting selectively and non-covalently with the transforming growth factor beta receptor. |
| type 3 melanocortin receptor binding | Interacting selectively and non-covalently with a type 3 melanocortin receptor. |
| type b gastrin/cholecystokinin receptor binding | Interacting selectively and non-covalently with a type B gastrin/cholecystokinin receptor. |
| ccr1 chemokine receptor binding | Interacting selectively and non-covalently with a CCR1 chemokine receptor. |
| methylenetetrahydrofolate reductase (nad(p)h) activity | Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+. |
| phosphoserine binding | Interacting selectively and non-covalently with a phosphorylated serine residue within a protein. |
| osmosensor activity | Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell. |
| rna-directed rna polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template. |
| neurotensin receptor activity, non-g-protein coupled | Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins. |
| purine ribonucleotide transmembrane transporter activity | Catalysis of the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other. |
| steroid 11-beta-monooxygenase activity | Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O. |
| coenzyme binding | Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. |
| n-acetylglucosamine kinase activity | Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H(+). |
| inhibitory mhc class i receptor activity | Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte. |
| erbb-3 class receptor binding | Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-3/HER3. |
| poly-purine tract binding | Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule. |
| histone demethylase activity (h3-k4 specific) | Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein. |
| af-2 domain binding | Interacting selectively and non-covalently with the AF-2 domain of a protein, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation. |
| endochitinase activity | Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain. |
| pyrroline-5-carboxylate reductase activity | Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. |
| prostaglandin-f synthase activity | Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate. |
| n-acetyllactosaminide alpha-2,3-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein. |
| bloc-2 complex binding | Interacting selectively and non-covalently with a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. |
| type ii activin receptor binding | Interacting selectively and non-covalently with a type II activin receptor. |
| translation factor activity, non-nucleic acid binding | A translation regulator activity that does not involve binding to nucleic acids. |
| arachidonate 15-lipoxygenase activity | Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate. |
| opioid peptide activity | Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect. |
| choline dehydrogenase activity | Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde. |
| 3-oxo-5-alpha-steroid 4-dehydrogenase activity | Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. |
| peroxisome matrix targeting signal-1 binding | Interacting selectively and non-covalently with a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L. |
| endopeptidase activator activity | Increases the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. |
| binding, bridging | The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. |
| selenocysteine lyase activity | Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor. |
| cholesterol 25-hydroxylase activity | Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O. |
| protoporphyrinogen oxidase activity | Catalysis of the reaction: protoporphyrinogen IX + acceptor = protoporphyrin IX + reduced acceptor. |
| benzodiazepine receptor activity | Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity. |
| 7-dehydrocholesterol reductase activity | Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+. |
| fha domain binding | Interacting selectively and non-covalently with a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich. |
| calcium sensitive guanylate cyclase activator activity | Increases the activity of guanylate cyclase in response to a change in calcium ion concentration. |
| succinate-coa ligase (adp-forming) activity | Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. |
| oligosaccharide binding | Interacting selectively and non-covalently with any oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. |
| nucleoside binding | Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose. |
| sodium:bicarbonate symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in). |
| calcium-dependent protein binding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium. |
| fad binding | Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. |
| lipopeptide binding | Interacting selectively and non-covalently with a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids. |
| nadh binding | Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. |
| sucrose alpha-glucosidase activity | Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose. |
| rna polymerase ii intronic transcription regulatory region sequence-specific dna binding | Interacting selectively and non-covalently with an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within. |
| steroid dehydrogenase activity, acting on the ch-ch group of donors | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor, and in which one substrate is a sterol derivative. |
| carnitine o-octanoyltransferase activity | Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA. |
| udp-n-acetylglucosamine transmembrane transporter activity | Catalysis of the transfer of a UDP-N-acetylglucosamine from one side of the membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. |
| lys63-specific deubiquitinase activity | Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein. |
| pyridoxal phosphatase activity | Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate. |
| n6-threonylcarbomyladenosine methylthiotransferase activity | Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A). |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor. |
| carnitine o-palmitoyltransferase activity | Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine. |
| 3-hydroxyanthranilate 3,4-dioxygenase activity | Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+). |
| fibronectin binding | Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. |
| vitamin d response element binding | Interacting selectively and non-covalently with the vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. |
| ceramide binding | Interacting selectively and non-covalently with any ceramide, a class of lipids that is composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes. |
| histone acetyltransferase binding | Interacting selectively and non-covalently with the enzyme histone acetyltransferase. |
| fibrinogen binding | Interacting selectively and non-covalently with fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade. |
| trans-hexaprenyltranstransferase activity | Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate. |
| inositol monophosphate 4-phosphatase activity | Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate. |
| repressing transcription factor binding | Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription. |
| heme binding | Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. |
| trimethyllysine dioxygenase activity | Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O(2) = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO(2) + succinate. |
| lipoyl(octanoyl) transferase activity | Catalysis of the reaction: octanoyl-[acyl-carrier protein] + protein = protein N6-(octanoyl)lysine + acyl-carrier protein. |
| inositol hexakisphosphate 6-kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate. |
| rab gtpase binding | Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases. |
| poly(a) binding | Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. |
| rrna (uridine-2'-o-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine. |
| aspartic endopeptidase activity, intramembrane cleaving | Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane. |
| phosphatidylinositol n-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol. |
| sweet taste receptor activity | Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste. |
| sumo-specific isopeptidase activity | Catalysis of the hydrolysis of an isopeptide bond between the small conjugating protein SUMO and a protein to which SUMO has been conjugated. |
| gamma-glutamyl carboxylase activity | Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide. |
| galactoside binding | Interacting selectively and non-covalently with any glycoside in which the sugar group is galactose. |
| formimidoyltransferase activity | Catalysis of the transfer of a formimino group from 5-formimidoyltetrahydrofolate to an acceptor molecule such as an amino acid. |
| core promoter proximal region sequence-specific dna binding | Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon. |
| nadh pyrophosphatase activity | Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+. |
| dna-3-methyladenine glycosylase activity | Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site. |
| frizzled-2 binding | Interacting selectively and non-covalently with frizzled-2 (fz2). |
| d3 vitamins binding | Interacting selectively and non-covalently with D3 vitamins. |
| lactate transmembrane transporter activity | Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. |
| odorant binding | Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell. |
| histone demethylase activity (h3-k9 specific) | Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein. |
| protein tyrosine phosphatase activator activity | Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein. |
| phenethylamine:oxygen oxidoreductase (deaminating) activity | Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+. |
| parathyroid hormone receptor activity | Combining with parathyroid hormone to initiate a change in cell activity. |
| testosterone dehydrogenase [nad(p)] activity | Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+. |
| molecular function regulator | |
| thyrotropin-releasing hormone activity | The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary. |
| metallocarboxypeptidase activity | Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| frizzled binding | Interacting selectively and non-covalently with the frizzled (fz) receptor. |
| glutathione hydrolase activity | Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. |
| pirna binding | Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. |
| nad(p)+ transhydrogenase (b-specific) activity | Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+. |
| protein-succinyllysine desuccinylase activity | Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide. |
| aryl hydrocarbon receptor activity | Combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding. |
| leukotriene-c4 synthase activity | Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4). |
| asparagine synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. |
| jun kinase kinase kinase activity | Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs). |
| hydrolase activity, hydrolyzing o-glycosyl compounds | Catalysis of the hydrolysis of any O-glycosyl bond. |
| l-dopa binding | Interacting selectively and non-covalently with L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid. |
| sumo binding | Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO. |
| double-stranded dna 5'-3' exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule. |
| methylenetetrahydrofolate dehydrogenase (nadp+) activity | |
| asialoglycoprotein receptor activity | Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane. |
| macrophage migration inhibitory factor binding | Interacting selectively and non-covalently with the cytokine, macrophage migration inhibitory factor. |
| fructokinase activity | Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate. |
| aspartate carbamoyltransferase activity | Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate. |
| mannose-1-phosphate guanylyltransferase activity | Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose. |
| corticotrophin-releasing factor receptor activity | Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity. |
| single-stranded dna endodeoxyribonuclease activity | Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks. |
| prostaglandin j receptor activity | Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity. |
| protein-glycine ligase activity | Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target protein. |
| cis-stilbene-oxide hydrolase activity | Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol. |
| kininogen binding | Interacting selectively and non-covalently with a kininogen, any of a group of plasma proteins that are kinin precursors. |
| gtp cyclohydrolase activity | Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. |
| prostaglandin d2 11-ketoreductase activity | Catalysis of the reaction: prostaglandin D2 + H+ + NADPH -> 11-epi-prostaglandin F2alpha + NADP+. |
| protein anchor | Interacting selectively and non-covalently with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific location on the membrane. |
| lipoprotein particle receptor binding | Interacting selectively and non-covalently with a lipoprotein particle receptor. |
| syntaxin binding | Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. |
| talin binding | Interacting selectively and non-covalently with a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types. |
| protein phosphatase inhibitor activity | Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins. |
| receptor tyrosine kinase binding | Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity. |
| gamma-glutamyltransferase activity | Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid. |
| transcription cofactor activity | Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. |
| sodium channel inhibitor activity | Stops, prevents, or reduces the activity of a sodium channel. |
| metal ion binding | Interacting selectively and non-covalently with any metal ion. |
| vitamin d binding | Interacting selectively and non-covalently with vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). |
| serine-type aminopeptidase activity | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| recombination hotspot binding | Interacting selectively and non-covalently with a region in a genome which promotes recombination. |
| atpase activity, coupled to transmembrane movement of ions | Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate. |
| phosphoenolpyruvate carboxykinase activity | Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products. |
| iron-responsive element binding | Interacting selectively and non-covalently with the iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins. |
| calcium-independent protein kinase c activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium. |
| calcium-dependent protein kinase c activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol and calcium. |
| methylarsonate reductase activity | Catalysis of the reaction: 2 glutathione + H(+) + methylarsonate = glutathione disulfide + H(2)O + methylarsonous acid. |
| death receptor binding | Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD). |
| h3 histone acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3. |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. |
| gtpase regulator activity | Modulates the rate of GTP hydrolysis by a GTPase. |
| isoprenoid binding | Interacting selectively and non-covalently with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. |
| nad transporter activity | Enables the directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells; transport may be of either the oxidized form, NAD, or the reduced form, NADH. |
| secondary active sulfate transmembrane transporter activity | Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. |
| rna polymerase ii transcription factor recruiting transcription factor activity | The function of binding to an RNA polymerase II (RNAP II) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP II. |
| ion binding | Interacting selectively and non-covalently with ions, charged atoms or groups of atoms. |
| udp-glucose:hexose-1-phosphate uridylyltransferase activity | Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose. |
| cystine secondary active transmembrane transporter activity | Catalysis of the transfer of cystine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. |
| calcidiol binding | Interacting selectively and non-covalently with calcidiol. |
| histidine-trna ligase activity | Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). |
| actinin binding | Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin. |
| l-serine transmembrane transporter activity | Catalysis of the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid. |
| histone deacetylase activity (h3-k14 specific) | Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein. |
| pyrimidine- and adenine-specific:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenine)(out) + Na+(out) = (pyrimidine nucleoside or adenine)(in) + Na+(in). |
| protein-tyrosine sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate. |
| dgtp binding | Interacting selectively and non-covalently with dGTP, deoxyguanosine triphosphate. |
| fucosyltransferase activity | Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
| (r)-2-hydroxyglutarate dehydrogenase activity | Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. |
| sugar-terminal-phosphatase activity | Catalysis of the reaction: H2O + sugar phosphorylated on the terminal carbon = a sugar + phosphate. |
| malonyltransferase activity | Catalysis of the transfer of a malonyl (HOOC-CH2-CO-) group to an acceptor molecule. |
| hydroxypyruvate isomerase activity | Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate. |
| arginine deiminase activity | Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3. |
| kinetochore binding | Interacting selectively and non-covalently with a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached. |
| regulatory region dna binding | Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair. |
| isocitrate dehydrogenase (nadp+) activity | Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+. |
| oxidoreductase activity, acting on phosphorus or arsenic in donors | Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
| serotonin receptor activity | Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. |
| alpha-ketoacid dehydrogenase activity | Catalysis of an oxidation-reduction (redox) reaction involving an alpha-ketoacid. |
| ikappab kinase activity | Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein. |
| bhlh transcription factor binding | Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. |
| protein c-terminal methylesterase activity | Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol. |
| interleukin-1, type ii receptor binding | Interacting selectively and non-covalently with a Type II interleukin-1 receptor. |
| metal ion transmembrane transporter activity | Catalysis of the transfer of metal ions from one side of a membrane to the other. |
| direct ligand regulated sequence-specific dna binding transcription factor activity | A DNA binding transcription factor activity that is directly regulated by binding of a ligand to the protein with this activity. Examples include the lac and trp repressors in E.coli and many steroid hormone receptors. |
| atp-dependent polyribonucleotide 5'-hydroxyl-kinase activity | Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA. |
| histone demethylase activity (h3-dimethyl-k4 specific) | Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein. |
| dna photolyase activity | Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA. |
| ribosomal s6-glutamic acid ligase activity | Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6. |
| notch binding | Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor. |
| nitric-oxide synthase activity | Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. |
| cholesterol o-acyltransferase activity | Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA. |
| leucine-trna ligase activity | Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu). |
| a-type (transient outward) potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential. |
| ring-like zinc finger domain binding | Interacting selectively and non-covalently with a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain. |
| atp transmembrane transporter activity | Catalysis of the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other. |
| complement component c4b receptor activity | Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| biliverdin reductase activity | Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+. |
| sodium-dependent multivitamin transmembrane transporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate. |
| 3-phosphoinositide-dependent protein kinase binding | Interacting selectively and non-covalently with a 3-phosphoinositide-dependent protein kinase. |
| phosphatidylinositol 3-kinase regulator activity | Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
| protein kinase a binding | Interacting selectively and non-covalently with any subunit of protein kinase A. |
| nucleosome-dependent atpase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of one or more nucleosomes. |
| 13-prostaglandin reductase activity | Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin. |
| histone kinase activity (h3-t6 specific) | Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3. |
| diacylglycerol o-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. |
| deubiquitinase activator activity | Increases the activity of deubiquitinase, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences. |
| molecular_function | Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions. |
| beta-1 adrenergic receptor binding | Interacting selectively and non-covalently with a beta-1 adrenergic receptor. |
| p-p-bond-hydrolysis-driven protein transmembrane transporter activity | Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. |
| sulfinoalanine decarboxylase activity | Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2. |
| sphinganine-1-phosphate aldolase activity | Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde. |
| ionotropic glutamate receptor activity | Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. |
| benzaldehyde dehydrogenase (nad+) activity | Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+. |
| 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity | Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone. |
| adenine phosphoribosyltransferase activity | Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. |
| carbon-oxygen lyase activity, acting on phosphates | Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate. |
| ccr chemokine receptor binding | Interacting selectively and non-covalently with a CCR chemokine receptor. |
| hormone activity | The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. |
| phosphatidylinositol-3,4-bisphosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions. |
| hydrolase activity, acting on acid anhydrides | Catalysis of the hydrolysis of any acid anhydride. |
| site-specific endodeoxyribonuclease activity, specific for altered base | Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks. |
| vegf-a-activated receptor activity | Combining with vascular endothelial growth factor A (VEGF-A) and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| polo kinase kinase activity | Catalysis of the addition of a phosphate group onto a serine or threonine residue in any member of the polo kinase class of proteins. |
| rna polymerase ii carboxy-terminal domain kinase activity | Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats. |
| follicle-stimulating hormone activity | The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis. |
| atpase regulator activity | Modulates the rate of ATP hydrolysis by an ATPase. |
| temperature-gated cation channel activity | Catalysis of the transmembrane transfer of a cation by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism). |
| receptor signaling protein activity | Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell. |
| iron-sulfur cluster binding | Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. |
| threonine-type endopeptidase activity | Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. |
| type 4 melanocortin receptor binding | Interacting selectively and non-covalently with a type 4 melanocortin receptor. |
| uridine phosphorylase activity | Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. |
| transcription regulatory region dna binding | Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. |
| glycoprotein binding | Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans. |
| camp binding | Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). |
| glycerol-3-phosphate o-acyltransferase activity | Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate. |
| lipid-transporting atpase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out). |
| interferon receptor activity | Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| cxcr4 chemokine receptor binding | Interacting selectively and non-covalently with a CXCR4 chemokine receptor. |
| inositol hexakisphosphate 1-kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate. |
| acetylgalactosaminyl-o-glycosyl-glycoprotein beta-1,6-n-acetylglucosaminyltransferase activity | Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R + UDP. |
| ornithine decarboxylase activity | Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine. |
| protein channel activity | Catalysis of energy-independent facilitated diffusion, mediated by passage of proteins through a transmembrane aqueous pore or channel. |
| interferon-gamma receptor binding | Interacting selectively and non-covalently with the interferon-gamma receptor. |
| fatty acid transporter activity | Enables the directed movement of fatty acids into, out of or within a cell, or between cells. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. |
| sterol desaturase activity | Catalysis of the introduction of a double bond into a sterol molecule. |
| secretin receptor activity | Combining with secretin to initiate a change in cell activity. |
| fk506 binding | Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506. |
| c-x-c chemokine receptor activity | Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif. |
| interleukin-1 receptor activity | Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response. |
| protein-glutamic acid ligase activity | Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein. |
| receptor signaling protein tyrosine kinase activator activity | Increases the activity of a receptor signaling protein tyrosine kinase. |
| ubiquitin activating enzyme activity | Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate. |
| anaphylatoxin receptor activity | Combining with anaphylatoxin to initiate a change in cell activity. |
| sulfite oxidase activity | Catalysis of the reaction: H(2)O + O(2) + sulfite = H(2)O(2) + H(+) + sulfate. |
| molecular transducer activity | The molecular function that accepts an input of one form and creates an output of a different form. |
| myosin head/neck binding | Interacting selectively and non-covalently with the head/neck region of a myosin heavy chain. |
| oxoglutarate:malate antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out). |
| interleukin-2 receptor activity | Combining with interleukin-2 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| medium-chain acyl-coa hydrolase activity | Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. A medium chain is a chain of between eight and twelve carbons in length. |
| four-way junction helicase activity | Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions. |
| interleukin-1 receptor antagonist activity | Blocks the binding of interleukin-1 to the interleukin-1 receptor complex. |
| dna (6-4) photolyase activity | Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA. |
| l-allo-threonine aldolase activity | Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde. |
| sirna binding | Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. |
| pyrimidine ribonucleotide binding | Interacting selectively and non-covalently with a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. |
| oxidoreductase activity, acting on the ch-oh group of donors, disulfide as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule. |
| jun kinase kinase activity | Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase. |
| 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity | Catalysis of the reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H(2)O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate. |
| 5'-deoxyribose-5-phosphate lyase activity | Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site. |
| enhancer sequence-specific dna binding | Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter. |
| cholestanetriol 26-monooxygenase activity | Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O. |
| gamma-aminobutyric acid transmembrane transporter activity | Catalysis of the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA). |
| phosphatidylserine decarboxylase activity | Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine. |
| pancreatic polypeptide receptor activity | Combining with pancreatic polypeptide PP to initiate a change in cell activity. |
| alpha-n-acetylglucosaminidase activity | Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. |
| peptidase activator activity involved in apoptotic process | Increases the activity of a peptidase that is involved in the apoptotic process. |
| prolactin-releasing peptide receptor binding | Interacting selectively and non-covalently with a prolactin-releasing peptide receptor. |
| transferase activity, transferring phosphorus-containing groups | Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). |
| cytokine receptor activity | Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| short-chain carboxylesterase activity | Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms. |
| interleukin-9 receptor binding | Interacting selectively and non-covalently with the interleukin-9 receptor. |
| porphobilinogen synthase activity | Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen. |
| structural constituent of nuclear pore | The action of a molecule that contributes to the structural integrity of the nuclear pore complex. |
| dol-p-man:man(7)glcnac(2)-pp-dol alpha-1,6-mannosyltransferase activity | Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. |
| histone acetyltransferase activity (h4-k12 specific) | Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12). |
| bisphosphoglycerate 2-phosphatase activity | Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate. |
| alpha-(1->3)-fucosyltransferase activity | Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage. |
| aldose 1-epimerase activity | Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose. |
| non-membrane spanning protein tyrosine kinase activity | Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate. |
| phosphatidylethanolamine n-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine. |
| oleoyl-[acyl-carrier-protein] hydrolase activity | Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate. |
| lead ion binding | Interacting selectively and non-covalently with lead (Pb) ions. |
| transferase activity, transferring sulfur-containing groups | Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor). |
| pyrin domain binding | Interacting selectively and non-covalently with a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain. |
| electron transporter, transferring electrons from coqh2-cytochrome c reductase complex and cytochrome c oxidase complex activity | Enables the directed movement of electrons from the CoQH2-cytochrome c reductase complex and the cytochrome c oxidase complex. |
| glutamate 5-kinase activity | Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+). |
| 3',5'-cyclic-nucleotide phosphodiesterase activity | Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate. |
| dna primase activity | Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase. |
| thiosulfate sulfurtransferase activity | Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate. |
| retinoic acid receptor binding | Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. |
| gkap/homer scaffold activity | Functions as a physical support bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses. |
| exodeoxyribonuclease iii activity | Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides. |
| dicarboxylic acid transmembrane transporter activity | Catalysis of the transfer of dicarboxylic acids from one side of the membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups. |
| thymidylate synthase activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. |
| ribokinase activity | Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. |
| telomeric template rna reverse transcriptase activity | Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template. |
| oxidoreductase activity, acting on the aldehyde or oxo group of donors, nad or nadp as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. |
| calcium:cation antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in). |
| eh domain binding | Interacting selectively and non-covalently with an EH domain of a protein. The EH stand for Eps15 homology. This was originally identified as a motif present in three copies at the NH2-termini of Eps15 and of the related molecule Eps15R. |
| gtp-rho binding | Interacting selectively and non-covalently with the GTP-bound form of the Rho protein. |
| trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity | Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol. |
| adp receptor activity | Combining with ADP and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| protein-lysine 6-oxidase activity | Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide. |
| nadp-retinol dehydrogenase activity | Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+. |
| bombesin receptor binding | Interacting selectively and non-covalently with a bombesin receptor. |
| sterol response element binding | Interacting selectively and non-covalently with the sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism. |
| 3'-tyrosyl-dna phosphodiesterase activity | Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA. |
| 3'(2'),5'-bisphosphate nucleotidase activity | Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate. |
| dna polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group. |
| protein tyrosine/serine/threonine phosphatase activity | Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| fructose binding | Interacting selectively and non-covalently with the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose. |
| linoleate 9s-lipoxygenase activity | Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate. |
| 2-(3-amino-3-carboxypropyl)histidine synthase activity | Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]. |
| 3'-flap endonuclease activity | Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis. |
| s-methyl-5-thioribose-1-phosphate isomerase activity | Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate. |
| udp-activated nucleotide receptor activity | Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP. |
| intermediate filament binding | Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. |
| double-stranded dna binding | Interacting selectively and non-covalently with double-stranded DNA. |
| smc family protein binding | Interacting selectively and non-covalently with any protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization. |
| choline binding | Interacting selectively and non-covalently with choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium. |
| brain-derived neurotrophic factor-activated receptor activity | Combining with a brain-derived neurotrophic factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| mit domain binding | Interacting selectively and non-covalently with the MIT domain of a protein. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking. |
| sodium-independent organic anion transmembrane transporter activity | Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. |
| sulfate adenylyltransferase activity | Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate. |
| (s)-3-amino-2-methylpropionate transaminase activity | Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate. |
| cxcr chemokine receptor binding | Interacting selectively and non-covalently with a chemokine receptor in the CXCR family. |
| methionine-r-sulfoxide reductase activity | Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on free oxidized methionine with specificity for the R enantiomer; does not act on oxidized methionine in peptide linkage. Thioredoxin disulfide is the oxidized form of thioredoxin. |
| phosphotransferase activity, for other substituted phosphate groups | Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). |
| flavonoid 3'-monooxygenase activity | Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O. |
| phosphatidylinositol phosphate kinase activity | Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate. |
| cuprous ion binding | Interacting selectively and non-covalently with cuprous ion, copper(1+). |
| camp-dependent protein kinase inhibitor activity | Stops, prevents or reduces the activity of a cAMP-dependent protein kinase. |
| transcription cofactor binding | Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. |
| deoxyhypusine synthase activity | Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+. |
| n-acetyllactosaminide beta-1,6-n-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. |
| complement component c5a receptor activity | Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| udp-galactose transmembrane transporter activity | Catalysis of the transfer of a UDP-galactose from one side of the membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate. |
| troponin i binding | Interacting selectively and non-covalently with troponin I, the inhibitory subunit of the troponin complex. |
| vinculin binding | Interacting selectively and non-covalently with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane. |
| histone binding | Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity. |
| 5'-tyrosyl-dna phosphodiesterase activity | Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA. |
| snrnp binding | Interacting selectively and non-covalently with any part of a small nuclear ribonucleoprotein particle. |
| 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity | Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate = 8-oxo-7,8-dihydroguanosine phosphate + diphosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription. |
| nucleoside-triphosphatase regulator activity | Modulates the rate of NTP hydrolysis by a NTPase. |
| hydrogen-exporting atpase activity, phosphorylative mechanism | Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle. |
| uridylate kinase activity | Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP. |
| intramolecular transferase activity, phosphotransferases | Catalysis of the transfer of a phosphate group from one position to another within a single molecule. |
| nad+ nucleosidase activity | Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose. |
| tpr domain binding | Interacting selectively and non-covalently with a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices. |
| arp2/3 complex binding | Interacting selectively and non-covalently with an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). |
| microtubule motor activity | Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). |
| gap junction channel activity involved in av node cell-bundle of his cell electrical coupling | A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction. |
| high-density lipoprotein particle binding | Interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE. |
| mannosyl-oligosaccharide mannosidase activity | Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides. |
| gaba receptor binding | Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. |
| nucleotide-sugar transmembrane transporter activity | Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. |
| dihydrolipoyl dehydrogenase activity | Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. |
| dna insertion or deletion binding | Interacting selectively and non-covalently with double-stranded DNA containing insertions or deletions. |
| 3-oxoacyl-[acyl-carrier-protein] reductase (nadph) activity | Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. |
| dephospho-coa kinase activity | Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+). |
| chemokine (c-c motif) ligand 7 binding | Interacting selectively and non-covalently with chemokine (C-C motif) ligand 7. |
| u1 snrna binding | Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA). |
| oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. |
| glutamate-cysteine ligase catalytic subunit binding | Interacting selectively and non-covalently with the catalytic subunit of glutamate-cysteine ligase. |
| rac gtpase binding | Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases. |
| galactose 3-o-sulfotransferase activity | Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc. |
| methylglutaconyl-coa hydratase activity | Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O. |
| 3-chloroallyl aldehyde dehydrogenase activity | Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid. |
| s-adenosylmethionine-dependent methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. |
| methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. |
| alpha-2a adrenergic receptor binding | Interacting selectively and non-covalently with an alpha-2A adrenergic receptor. |
| acetylcholine binding | Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. |
| thienylcyclohexylpiperidine binding | Interacting selectively and non-covalently with thienylcyclohexylpiperidine. |
| long-chain-3-hydroxyacyl-coa dehydrogenase activity | Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
| trialkylsulfonium hydrolase activity | Catalysis of the hydrolysis of a thioether bond, -S-. |
| tetrahydrobiopterin binding | Interacting selectively and non-covalently with a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions. |
| beta-galactoside alpha-2,6-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine. |
| pheromone receptor activity | Combining with a pheromone to initiate a change in cell activity. A pheromone is a substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behavior. |
| cysteine-type endopeptidase activity involved in apoptotic signaling pathway | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway. |
| nicotinic acid receptor activity | Combining with nicotinic acid to initiate a change in cell activity. |
| heparosan-n-sulfate-glucuronate 5-epimerase activity | Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate. |
| secondary active organic cation transmembrane transporter activity | Catalysis of the transfer of organic cations from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. |
| hydrogen-exporting atpase activity | Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). |
| l-methionine transmembrane transporter activity | Catalysis of the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid. |
| protein deacetylase activity | Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate. |
| ral gtpase binding | Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases. |
| opioid receptor binding | Interacting selectively and non-covalently with an opioid receptor. |
| poly(a) rna binding | Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
| haptoglobin binding | Interacting selectively and non-covalently with a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex. |
| alpha-1,3-mannosylglycoprotein 2-beta-n-acetylglucosaminyltransferase activity | Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP. |
| cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity | Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+). |
| sh2 domain binding | Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. |
| cis-trans isomerase activity | Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers. |
| voltage-gated calcium channel activity | Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| arylsulfatase activity | Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. |
| phosphate transmembrane transporter activity | Catalysis of the transfer of phosphate from one side of the membrane to the other. |
| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. |
| translation release factor activity, codon specific | A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. |
| ctp binding | Interacting selectively and non-covalently with CTP, cytidine 5'-triphosphate. |
| copper chaperone activity | Assists in the delivery of copper ions to target proteins or compartments. |
| catalase activity | Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O. |
| calcium-dependent protein serine/threonine phosphatase regulator activity | Modulation of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase. |
| trna methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. |
| calcitonin family binding | Interacting selectively and non-covalently with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)). |
| nitric oxide dioxygenase activity | Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+. |
| molybdate ion transmembrane transporter activity | Catalysis of the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid. |
| sedoheptulose-7-phosphate:d-glyceraldehyde-3-phosphate glyceronetransferase activity | Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. |
| short-chain fatty acid transporter activity | Enables the directed movement of short-chain fatty acids into, out of or within a cell, or between cells. Short-chain fatty acids are fatty acids with a chain length of less than C6. |
| oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen. |
| leukotriene receptor activity | Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine. |
| trna 2'-phosphotransferase activity | Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate. |
| glycine c-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+). |
| guanylate cyclase activity | Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. |
| deoxyribose-phosphate aldolase activity | Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. |
| calcium channel inhibitor activity | Stops, prevents, or reduces the activity of a calcium channel. |
| udp-glucose 4-epimerase activity | Catalysis of the reaction: UDP-glucose = UDP-galactose. |
| dna topoisomerase type i activity | Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. |
| extracellular-glutamate-gated ion channel activity | Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. |
| galanin receptor activity | Combining with galanin to initiate a change in cell activity. |
| long-chain fatty acyl-coa binding | Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more. |
| oxidoreductase activity, acting on ch or ch2 groups, disulfide as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group. |
| pyruvate carboxylase activity | Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate. |
| chondroitin sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate. |
| platelet-derived growth factor-activated receptor activity | Combining with platelet-derived growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| norepinephrine:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) = norepinephrine(in) + Na+(in). |
| microtubule binding | Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. |
| metalloenzyme regulator activity | Modulates the activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal. |
| rna polymerase ii transcription corepressor binding | Interacting selectively and non-covalently with an RNA polymerase II transcription corepressor, any protein involved in negative regulation of transcription by RNA polymerase II via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery of RNA polymerase II. |
| phosphatidylinositol phosphate phosphatase activity | Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate. |
| group iii metabotropic glutamate receptor activity | A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity. |
| purine nucleobase binding | Interacting selectively and non-covalently with a purine nucleobase, an organic nitrogenous base with a purine skeleton. |
| transforming growth factor beta-activated receptor activity | Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity | Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate. |
| gtpase inhibitor activity | Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. |
| left-handed z-dna binding | Interacting selectively and non-covalently with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags. |
| virion binding | Interacting selectively and non-covalently with a virion, either by binding to components of the capsid or the viral envelope. |
| map kinase kinase activity | Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. |
| calcium ion transmembrane transporter activity | Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. |
| myosin light chain kinase activity | Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate. |
| copper-transporting atpase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+ = ADP + phosphate + Cu2+, directly driving the transport of the copper ions across a membrane. |
| glutamate-cysteine ligase activity | Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate. |
| supercoiled dna binding | Interacting selectively and non-covalently with supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA. |
| 7sk snrna binding | Interacting selectively and non-covalently with a 7SK small nuclear RNA (7SK snRNA). |
| voltage-gated cation channel activity | Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| galactokinase activity | Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+). |
| aminobutyraldehyde dehydrogenase activity | Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+. |
| mrna methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule. |
| peroxiredoxin activity | Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. |
| kinase inhibitor activity | Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| rna cap binding | Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. |
| uracil binding | Interacting selectively and non-covalently with uracil. |
| alanine-oxo-acid transaminase activity | Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid. |
| pyrimidine-nucleoside phosphorylase activity | Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate. |
| chemokine (c-c motif) ligand 21 binding | Interacting selectively and non-covalently with chemokine (C-C motif) ligand 21. |
| gdp-d-glucose phosphorylase activity | Catalysis of the reaction: GDP-D-glucose + phosphate = D-glucose-1-P + GDP. |
| atpase inhibitor activity | Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of ATP to ADP and orthophosphate. |
| prostaglandin f receptor activity | Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity. |
| rna pyrophosphohydrolase activity | Catalysis of the removal of a 5' terminal pyrophosphate from the 5'-triphosphate end of an RNA, leaving a 5'-monophosphate end. |
| carnitine o-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA. |
| serotonin:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) = serotonin(in) + Na+(in). |
| inositol 1,4,5 trisphosphate binding | Interacting selectively and non-covalently with inositol 1,4,5 trisphosphate. |
| oxidoreductase activity, acting on nad(p)h, nitrogenous group as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
| glucocorticoid receptor binding | Interacting selectively and non-covalently with a glucocorticoid receptor. |
| adrenergic receptor activity | Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex. |
| gaba receptor activity | Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms. |
| phosphotransferase activity, carboxyl group as acceptor | Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). |
| acetylcholine transmembrane transporter activity | Catalysis of the transfer of acetylcholine from one side of the membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. |
| fatty-acyl-coa reductase (alcohol-forming) activity | Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. |
| l-dopa decarboxylase activity | Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine. |
| beta-tubulin binding | Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin. |
| deoxynucleoside-diphosphatase activity | Catalysis of the reaction: a deoxynucleoside diphosphate + H2O = a deoxynucleotide + phosphate. |
| diacylglycerol binding | Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids. |
| phosphoserine phosphatase activity | Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate. |
| purine nucleobase transmembrane transporter activity | Catalysis of the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other. |
| orexigenic neuropeptide qrfp receptor binding | Interacting selectively and non-covalently with an orexigenic neuropeptide QRFP receptor. |
| glutamate:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in). |
| hydrolase activity, acting on acid carbon-carbon bonds | Catalysis of the hydrolysis of any acid carbon-carbon bond. |
| ferrous iron transmembrane transporter activity | Catalysis of the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. |
| glutamate binding | Interacting selectively and non-covalently with glutamate, the anion of 2-aminopentanedioic acid. |
| alpha-l-arabinofuranosidase activity | Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides. |
| galactosylceramidase activity | Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine. |
| cytokine receptor binding | Interacting selectively and non-covalently with a cytokine receptor. |
| biotinidase activity | Catalysis of the reaction: biotin amide + H2O = biotin + NH3. |
| voltage-gated ion channel activity | Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| g-protein alpha-subunit binding | Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. |
| inward rectifier potassium channel inhibitor activity | Stops, prevents, or reduces the activity of an inwardly rectifying potassium channel. |
| atp-dependent 3'-5' dna helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'. |
| glucuronosyl-n-acetylgalactosaminyl-proteoglycan 4-beta-n-acetylgalactosaminyltransferase activity | Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP. |
| ribonuclease inhibitor activity | Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA. |
| flap endonuclease activity | Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis. |
| malate dehydrogenase (nadp+) activity | Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+. |
| indanol dehydrogenase activity | Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+. |
| cysteine-type endopeptidase activity involved in execution phase of apoptosis | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis. |
| macromolecular complex binding | Interacting selectively and non-covalently with any macromolecular complex. |
| roundabout binding | Interacting selectively and non-covalently with the Roundabout (ROBO) receptor, a transmembrane receptor. |
| protein tyrosine/threonine phosphatase activity | Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| d-lactate dehydrogenase (cytochrome) activity | Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c. |
| gluconolactonase activity | Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate. |
| oxidoreductase activity, acting on the ch-ch group of donors, nad or nadp as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. |
| glutathione peroxidase activity | Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. |
| translation release factor activity, codon nonspecific | A translation release factor that is not specific to particular codons; binds to guanine nucleotides. |
| quinone cofactor methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1). |
| sodium ion transmembrane transporter activity | Catalysis of the transfer of sodium ions (Na+) from one side of a membrane to the other. |
| protein phosphatase activator activity | Increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
| high-affinity arginine transmembrane transporter activity | Catalysis of the transfer of arginine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. |
| utp:glucose-1-phosphate uridylyltransferase activity | Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose. |
| sulfonylurea receptor activity | Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| acetyl-coa:l-lysine n6-acetyltransferase | Catalysis of the reaction: L-lysine + acetyl-CoA = N6-acetyl-L-lysine + CoA + H(+). |
| acyl-coa oxidase activity | Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide. |
| apolipoprotein receptor activity | Combining with an apolipoprotein to initiate a change in cell activity. |
| neutral l-amino acid secondary active transmembrane transporter activity | Catalysis of the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. |
| ccr4 chemokine receptor binding | Interacting selectively and non-covalently with a CCR4 chemokine receptor. |
| oxidoreductase activity, acting on nad(p)h, quinone or similar compound as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. |
| adenosine-diphosphatase activity | Catalysis of the reaction: ADP + H2O = AMP + phosphate. |
| glycoprotein endo-alpha-1,2-mannosidase activity | Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane. |
| dolichyl-phosphate-mannose-protein mannosyltransferase activity | Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein. |
| beta1-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors. |
| peptide yy receptor activity | Combining with gut peptide YY to initiate a change in cell activity. |
| purine-specific mismatch base pair dna n-glycosylase activity | Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. |
| potassium channel activity | Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| 1-alpha,25-dihydroxyvitamin d3 24-hydroxylase activity | Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol). |
| chloride channel regulator activity | Modulates the activity of a chloride channel. |
| dna clamp loader activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex. |
| 5-aminolevulinate synthase activity | Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA. |
| protein antigen binding | Interacting selectively and non-covalently with a protein antigen. |
| hydrolase activity, acting on acid sulfur-nitrogen bonds | Catalysis of the hydrolysis of any acid sulfur-nitrogen bond. |
| ribulose-phosphate 3-epimerase activity | Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate. |
| phosphatidylinositol bisphosphate phosphatase activity | Catalysis of the reaction: phosphatidylinositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate. |
| purine ribonucleotide binding | Interacting selectively and non-covalently with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. |
| steroid hormone receptor binding | Interacting selectively and non-covalently with a steroid hormone receptor. |
| extracellular matrix protein binding | Interacting selectively and non-covalently with a protein that is part of an extracellular matrix. |
| cadherin binding | Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion. |
| sodium:potassium:chloride symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in). |
| basal rna polymerase ii transcription machinery binding | Interacting selectively and non-covalently with the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase. |
| mercury ion binding | Interacting selectively and non-covalently with mercury (Hg) ions. |
| trna (adenine) methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine. |
| neurotrophin binding | Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth. |
| acetyl-coa carboxylase activity | Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. |
| rna polymerase ii distal enhancer sequence-specific dna binding transcription factor activity involved in negative regulation of transcription | Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| carbonate dehydratase activity | Catalysis of the reaction: H2CO3 = CO2 + H2O. |
| keratin filament binding | Interacting selectively and non-covalently with a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. |
| beta-n-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity | Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide. |
| endopeptidase regulator activity | Modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. |
| voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| calcitonin gene-related peptide receptor activity | Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity. |
| voltage-gated sodium channel activity involved in bundle of his cell action potential | Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| g-protein coupled bile acid receptor activity | Combining with an extracellular bile acid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| superoxide-generating nadph oxidase activator activity | Increases the activity of the enzyme superoxide-generating NADPH oxidase. |
| mutsalpha complex binding | Interacting selectively and non-covalently with the mismatch repair complex MutSalpha. |
| inositol tetrakisphosphate 3-kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate. |
| amylo-alpha-1,6-glucosidase activity | Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present. |
| cation:cation antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out). |
| structural constituent of myelin sheath | The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve. |
| n-acetylglucosamine-6-sulfatase activity | Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. |
| guanyl ribonucleotide binding | Interacting selectively and non-covalently with a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. |
| histone-lysine n-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. |
| mediator complex binding | Interacting selectively and non-covalently with a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
| atp-dependent nad(p)h-hydrate dehydratase activity | Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H(+) + NADH + phosphate. |
| phosphopantothenate--cysteine ligase activity | Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives. |
| transforming growth factor beta receptor activity, type iii | Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors. |
| s100 protein binding | Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. |
| gtp cyclohydrolase binding | Interacting selectively and non-covalently with a GTP cyclohydrolase. |
| kinase activator activity | Increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| chloride ion binding | Interacting selectively and non-covalently with chloride ions (Cl-). |
| cargo receptor activity | Combining selectively with an extracellular macromolecule and delivering the macromolecule into the cell via endocytosis. |
| sialate o-acetylesterase activity | Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate. |
| protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| nad binding | |
| adenylate kinase activity | Catalysis of the reaction: ATP + AMP = 2 ADP. |
| heparan sulfate 6-o-sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate. |
| vitamin-k-epoxide reductase (warfarin-sensitive) activity | Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol. |
| ubiquitin-like protein conjugating enzyme binding | |
| sequence-specific dna binding rna polymerase i transcription factor activity | Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase I. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. |
| thiocyanate peroxidase activity | Catalysis of the reaction: thiocyanate (SCN-) + hydrogen peroxide (H2O2) = hypothiocyanite (OSCN-) + 2 H2O. Catalyzes the hydrogen peroxide oxidation of thiocyanate. |
| phosphatidylinositol 3-kinase regulatory subunit binding | Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location. |
| atp-dependent peptidase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds. |
| diiodophenylpyruvate reductase activity | Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH. |
| protein c-terminus binding | Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
| ubiquitin-ubiquitin ligase activity | Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. |
| nucleoside-triphosphatase activity | Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. |
| ferrochelatase activity | Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX. |
| protein tyrosine kinase inhibitor activity | Stops, prevents or reduces the activity of a protein tyrosine kinase. |
| 3-oxoacid coa-transferase activity | Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA. |
| cgmp-stimulated cyclic-nucleotide phosphodiesterase activity | Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP. |
| single-stranded dna exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule. |
| dihydroorotase activity | Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+). |
| trna adenylyltransferase activity | Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1). |
| monoamine transmembrane transporter activity | Catalysis of the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of the membrane to the other. |
| transition metal ion transmembrane transporter activity | Catalysis of the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. |
| delta24(24-1) sterol reductase activity | Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH. |
| lysophospholipid acyltransferase activity | Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid. |
| beta-glucuronidase activity | Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate. |
| dihydropyrimidine dehydrogenase (nadp+) activity | Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+. |
| complement component c3b binding | Interacting selectively and non-covalently with the C3b product of the complement cascade. |
| angiotensin type ii receptor activity | An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms. |
| stearoyl-coa 9-desaturase activity | Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O. |
| histamine oxidase activity | Catalysis of the reaction: histamine + H2O + O2 = imidazole-4-acetaldehyde + NH3 + hydrogen peroxide + H+. |
| sterol-transporting atpase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out). |
| biotin binding | Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. |
| rna-3'-phosphate cyclase activity | Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate. |
| quinone binding | Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. |
| azole transmembrane transporter activity | Catalysis of the transfer of azole from one side of the membrane to the other. |
| nucleotide kinase activity | Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. |
| sterol 5-alpha reductase activity | Catalysis of the removal of a C-5 double bond in the B ring of a sterol. |
| protein kinase a catalytic subunit binding | Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A. |
| interleukin-22 receptor binding | Interacting selectively and non-covalently with the interleukin-22 receptor. |
| triokinase activity | Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H(+). |
| catalytic activity | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. |
| ribosomal small subunit binding | Interacting selectively and non-covalently with any part of the small ribosomal subunit. |
| growth hormone-releasing hormone receptor binding | Interacting selectively and non-covalently with a growth hormone-releasing hormone receptor. |
| carnitine o-acyltransferase activity | Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule. |
| xylosyltransferase activity | Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
| cation:chloride symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in). |
| nf-kappab-inducing kinase activity | Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK). |
| phosphotransferase activity, alcohol group as acceptor | Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). |
| high-affinity glutamate transmembrane transporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + H+(out) = glutamate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. |
| holocytochrome-c synthase activity | Catalysis of the reaction: holocytochrome c = apocytochrome c + heme. |
| phosphorylase kinase regulator activity | Modulation of the activity of the enzyme phosphorylase kinase. |
| extracellular atp-gated cation channel activity | Catalysis of the transmembrane transfer of a cation by a channel that opens when extracellular ATP has been bound by the channel complex or one of its constituent parts. |
| beta-1,4-mannosylglycoprotein 4-beta-n-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R. |
| p2y1 nucleotide receptor binding | Interacting selectively and non-covalently with a P2Y1 nucleotide receptor. |
| dna polymerase binding | Interacting selectively and non-covalently with a DNA polymerase. |
| guanylate cyclase regulator activity | Modulates the activity of guanylate cyclase. |
| salt transmembrane transporter activity | Catalysis of the transfer of salt from one side of the membrane to the other. |
| mhc protein binding | Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. |
| ammonium transmembrane transporter activity | Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. |
| growth hormone-releasing hormone activity | The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland. |
| small protein activating enzyme activity | Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. |
| kynurenine aminotransferase activity | Catalysis of the transfer of an amino group from kynurenine to an acceptor, usually a 2-oxo acid. |
| inositol hexakisphosphate binding | Interacting selectively and non-covalently with inositol hexakisphosphate. |
| activin receptor binding | Interacting selectively and non-covalently with an activin receptor. |
| phosphate ion carrier activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate (cyt) + H+ (cyt) = phosphate (mitochondrion) + H+ (mitochondrion). |
| troponin c binding | Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex. |
| bicarbonate transmembrane transporter activity | Catalysis of the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. |
| carbohydrate derivative binding | Interacting selectively and non-covalently with a carbohydrate derivative. |
| malic enzyme activity | Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. |
| acp phosphopantetheine attachment site binding | Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP). |
| lysophosphatidic acid acyltransferase activity | Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid. |
| map kinase kinase kinase kinase activity | Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli. |
| 8-oxo-gdp phosphatase activity | Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate. |
| gdp binding | Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate. |
| endothelial differentiation g-protein coupled receptor binding | Interacting selectively and non-covalently with an endothelial differentiation G-protein coupled receptor. |
| rna polymerase ii transcription cofactor binding | Interacting selectively and non-covalently with a transcription cofactor for RNA polymerase II, any protein involved in regulation of transcription via protein-protein interactions with RNA polymerase II transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery of RNA polymerase II. |
| rna trimethylguanosine synthase activity | Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine. |
| phosphatidylcholine binding | Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline. |
| purine nucleoside binding | Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose. |
| mevalonate transmembrane transporter activity | Catalysis of the transfer of mevalonate from one side of the membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds. |
| gdp-l-fucose synthase activity | Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+. |
| sphingosine-1-phosphate phosphatase activity | Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate. |
| l-arginine transmembrane transporter activity | Catalysis of the stereospecific transfer of L-arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane. |
| secondary active oligopeptide transmembrane transporter activity | Catalysis of the transfer of an oligopeptide or oligopeptides from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. |
| transferase activity, transferring glycosyl groups | Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). |
| thioether s-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium. |
| snorna binding | Interacting selectively and non-covalently with small nucleolar RNA. |
| histone methyltransferase activity (h3-k9 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein. |
| calcitriol binding | Interacting selectively and non-covalently with calcitriol. Calcitriol (1,25-dihydroxycholecalciferol) is the hormonally active form of vitamin D3. |
| methylputrescine oxidase activity | Catalysis of the reaction: N-methylputrescine + H2O + O2 = N-methylaminobutanal + NH3 + hydrogen peroxide + H+. |
| single-strand selective uracil dna n-glycosylase activity | Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA. |
| alpha-glucosidase activity | Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose. |
| n-acetylgalactosamine kinase activity | Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate. |
| diphthine-ammonia ligase activity | Catalysis of the reaction: ATP + diphthine + NH(4)(+) = ADP + diphthamide + H(+) + phosphate. |
| chromatin dna binding | Interacting selectively and non-covalently with DNA that is assembled into chromatin. |
| testosterone dehydrogenase (nad+) activity | Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH. |
| protein prenyltransferase activity | Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein. |
| photoreceptor activity | The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. |
| g-protein beta/gamma-subunit complex binding | Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits. |
| antigen binding | Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. |
| molybdenum ion binding | Interacting selectively and non-covalently with molybdenum (Mo) ions. |
| trna (guanine-n7-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine. |
| phosphopentomutase activity | Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate. |
| oxidoreductase activity, acting on the ch-nh group of donors | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
| ubiquitin-like protein-specific protease activity | Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated. |
| choline-phosphate cytidylyltransferase activity | Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline. |
| steroid 7-alpha-hydroxylase activity | Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O. |
| lipid binding | Interacting selectively and non-covalently with a lipid. |
| n-methyl-d-aspartate selective glutamate receptor activity | An ionotropic glutamate receptor activity that exhibits slow gating by glutamate, acts by opening a nonselective cation channel, and can be activated by L-aspartate. |
| xenobiotic transporter activity | Enables the directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells. |
| nad(p)+ nucleosidase activity | Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide. |
| vascular endothelial growth factor-activated receptor activity | Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| solute:proton symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in). |
| poly-glutamine tract binding | Interacting selectively and non-covalently with a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein. |
| 4-alpha-glucanotransferase activity | Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan. |
| melanin-concentrating hormone receptor activity | Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity. |
| protein binding involved in protein folding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding. |
| gaba-gated chloride ion channel activity | Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts. |
| interleukin-9 binding | Interacting selectively and non-covalently with interleukin-9. |
| calmodulin-dependent protein phosphatase activity | Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin. |
| endodeoxyribonuclease activity, producing 5'-phosphomonoesters | Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. |
| chemokine receptor binding | Interacting selectively and non-covalently with any chemokine receptor. |
| spectrin binding | Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. |
| atpase activity, uncoupled | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction is not directly coupled to any other reaction. |
| n-acetylgalactosamine 4-o-sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate. |
| beta-2 adrenergic receptor binding | Interacting selectively and non-covalently with a beta-2 adrenergic receptor. |
| histidine decarboxylase activity | Catalysis of the reaction: L-histidine = histamine + CO2. |
| acyl-coa desaturase activity | Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = desaturated-acyl-CoA + acceptor + 2 H2O. |
| inositol bisdiphosphate tetrakisphosphate diphosphatase activity | Catalysis of the reaction: inositol bisdiphosphate tetrakisphosphate + H2O = inositol diphosphate pentakisphosphate + phosphate. |
| nadh dehydrogenase (ubiquinone) activity | Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. |
| acetylcholine-gated cation channel activity | Catalysis of the transmembrane transfer of a cation by a channel that opens when acetylcholine has been bound by the channel complex or one of its constituent parts. |
| histone pre-mrna stem-loop binding | Interacting selectively and non-covalently with a conserved stem-loop structure found in histone pre-mRNAs. |
| solute:proton antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). |
| 9-cis retinoic acid receptor activity | Combining with 9-cis retinoic acid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. |
| [acyl-carrier-protein] s-malonyltransferase activity | Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]. |
| limonene monooxygenase activity | Catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene. |
| chondroitin sulfate binding | Interacting selectively and non-covalently with chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). |
| macrolide binding | Interacting selectively and non-covalently with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species. |
| calcium:sodium antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in). |
| glutaminase activity | Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3. |
| deoxyhypusine monooxygenase activity | Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O. |
| ferric-chelate reductase activity | Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H(+). |
| pyrimidine nucleobase binding | Interacting selectively and non-covalently with a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton. |
| lyase activity | Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. |
| h4 histone acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4. |
| phospho-n-acetylmuramoyl-pentapeptide-transferase activity | Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol. |
| rna polymerase i transcription factor binding | Interacting selectively and non-covalently with an RNA polymerase I transcription factor, any protein required to initiate or regulate transcription by RNA polymerase I. |
| intermediate conductance calcium-activated potassium channel activity | Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. |
| lithium ion binding | Interacting selectively and non-covalently with lithium ions (Li+). |
| voltage-gated calcium channel activity involved in cardiac muscle cell action potential | Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| sumo ligase activity | Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S --> X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate. |
| fmn transmembrane transporter activity | Enables the directed movement of flavine mononucleotide (FMN) into, out of or within a cell, or between cells. |
| protein domain specific binding | Interacting selectively and non-covalently with a specific domain of a protein. |
| copper-dependent protein binding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of copper. |
| glutamate dehydrogenase [nad(p)+] activity | |
| chitinase activity | Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. |
| hydroxylysine kinase activity | Catalysis of the reaction: erythro-5-hydroxy-L-lysine + GTP = 5-phosphonooxy-L-lysine + GDP + 2 H(+). |
| nadhx epimerase activity | Catalysis of the reaction: (R)-NADHX = (S)-NADHX. |
| keratan sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate. |
| volume-sensitive anion channel activity | Catalysis of the transmembrane transfer of an anion by a volume-sensitive channel. An anion is a negatively charged ion. A volume-sensitive channel is a channel that responds to changes in the volume of a cell. |
| peptide binding | Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds. |
| all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity | Catalysis of the reaction: H(2)O + all-trans-retinyl ester = 11-cis-retinol + fatty acid. |
| single-stranded telomeric dna binding | Interacting selectively and non-covalently with single-stranded telomere-associated DNA. |
| acetylglucosaminyltransferase activity | Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. |
| adenyl ribonucleotide binding | Interacting selectively and non-covalently with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. |
| coa-ligase activity | Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA. |
| dinucleotide insertion or deletion binding | Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide insertion or deletion. |
| icosanoid receptor activity | Combining with an icosanoid to initiate a change in cell activity. |
| type i interferon receptor binding | Interacting selectively and non-covalently with an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2). |
| 1-phosphatidylinositol 4-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+). |
| gastric inhibitory peptide receptor activity | Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein. |
| solute:cation symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in). |
| hlh domain binding | Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. |
| exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. |
| amp transmembrane transporter activity | Catalysis of the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other. |
| dimethylallyltranstransferase activity | Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. |
| protein phosphatase 2b binding | Interacting selectively and non-covalently with the enzyme protein phosphatase 2B. |
| alcohol binding | Interacting selectively and non-covalently with an alcohol, any of a class of alkyl compounds containing a hydroxyl group. |
| cholate-coa ligase activity | Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA. |
| procollagen-proline 3-dioxygenase activity | Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2. |
| calcitonin receptor binding | Interacting selectively and non-covalently with a calcitonin receptor. |
| 1-alkyl-2-acetylglycerophosphocholine esterase activity | Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate. |
| extracellular matrix constituent conferring elasticity | A component of the extracellular matrix that enables the matrix to recoil after transient stretching. |
| molybdopterin cofactor binding | Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. |
| estrone sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate. |
| angiotensin receptor activity | Combining with angiotensin to initiate a change in cell activity. |
| adenyl nucleotide binding | Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate. |
| cerebroside-sulfatase activity | Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate. |
| protein-cysteine s-palmitoyltransferase activity | Catalysis of the transfer of a palmitoyl group to a sulfur atom on the cysteine of a protein molecule. |
| choriogonadotropin hormone binding | Interacting selectively and non-covalently with choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit. |
| cobalt ion binding | Interacting selectively and non-covalently with a cobalt (Co) ion. |
| high-affinity oligopeptide transporter activity | Catalysis of the transfer of oligopeptide from one side of the membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. |
| protein farnesyltransferase activity | Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate. |
| peptidyl-histidine dioxygenase activity | Catalysis of the reaction: peptidyl L-histidine + 2-oxoglutarate + O2 = peptidyl hydroxy-L-histidine + succinate + CO2. |
| endoribonuclease inhibitor activity | Stops, prevents or reduces the activity of an endoribonuclease, any enzyme that catalyzes the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. |
| bh domain binding | Interacting selectively and non-covalently with the Bcl-2 homology (BH) domain of a protein. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains. |
| single-stranded rna binding | Interacting selectively and non-covalently with single-stranded RNA. |
| endothelin receptor activity | Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| protein tyrosine phosphatase activity | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| cyclic nucleotide binding | Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. |
| thyroid hormone receptor activity | Combining with thyroid hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. |
| very long-chain fatty acid-coa ligase activity | Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22. |
| carbohydrate transmembrane transporter activity | Catalysis of the transfer of carbohydrate from one side of the membrane to the other. |
| tfiiic-class transcription factor binding | Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIC class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III. |
| phosphatidyl-n-methylethanolamine n-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine. |
| racemase activity, acting on amino acids and derivatives | Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative. |
| serotonin-activated cation-selective channel activity | Catalysis of the transmembrane transfer of a cation by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, and that is activated by serotonin. |
| vascular endothelial growth factor receptor binding | Interacting selectively and non-covalently with any vascular endothelial growth factor receptor. |
| c-x-c chemokine binding | Interacting selectively and non-covalently with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif. |
| cell adhesion molecule binding | Interacting selectively and non-covalently with a cell adhesion molecule. |
| aspartate binding | Interacting selectively and non-covalently with aspartate, the alpha-amino-acid anion of 2-aminobutanedioic acid that has formula C4H5NO4. |
| ccr2 chemokine receptor binding | Interacting selectively and non-covalently with a CCR2 chemokine receptor. |
| adenosine 3',5'-bisphosphate transmembrane transporter activity | Catalysis of the transfer of adenosine 3',5'-bisphosphate from one side of a membrane to the other. |
| rna methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. |
| toll-like receptor binding | Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response. |
| molybdopterin synthase activity | Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis. |
| selenocysteine insertion sequence binding | Interacting selectively and non-covalently with the selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation. |
| histone threonine kinase activity | Catalysis of the transfer of a phosphate group to a threonine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. |
| serine transmembrane transporter activity | Catalysis of the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid. |
| atp-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity | Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA. |
| eukaryotic initiation factor 4e binding | Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation. |
| gamma-aminobutyric acid:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) = gamma-aminobutyric acid(in) + Na+(in). |
| nucleotidyltransferase activity | Catalysis of the transfer of a nucleotidyl group to a reactant. |
| chemorepellent activity | Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. |
| alpha-(1->6)-fucosyltransferase activity | Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage. |
| thiamine binding | Interacting selectively and non-covalently with thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. |
| 3-mercaptopyruvate sulfurtransferase activity | Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate. |
| interleukin-8 receptor binding | Interacting selectively and non-covalently with the interleukin-8 receptor. |
| tyrosyl-dna phosphodiesterase activity | Catalysis of the hydrolysis of phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA. |
| citrate-l-glutamate ligase activity | Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate. |
| gamma-butyrobetaine dioxygenase activity | Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O(2) = carnitine + CO(2) + succinate. |
| lactoylglutathione lyase activity | Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. |
| serine-trna ligase activity | Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). |
| mrna 3'-utr binding | Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule. |
| single-stranded dna binding | Interacting selectively and non-covalently with single-stranded DNA. |
| co-smad binding | Interacting selectively and non-covalently with a common mediator SMAD signaling protein. |
| procollagen galactosyltransferase activity | Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine. |
| icosanoid transmembrane transporter activity | Catalysis of the transfer of icosanoids from one side of the membrane to the other. |
| nucleobase-containing compound transmembrane transporter activity | Catalysis of the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. |
| cholestenol delta-isomerase activity | Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol. |
| sulfiredoxin activity | Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R. |
| histone demethylase activity (h3-k36 specific) | Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 36) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 36 of the histone H3 protein. |
| substrate-specific channel activity | Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules. |
| d4 dopamine receptor binding | Interacting selectively and non-covalently with a D4 dopamine receptor. |
| type ii transforming growth factor beta receptor binding | Interacting selectively and non-covalently with a type II transforming growth factor beta receptor. |
| microfibril binding | Interacting selectively and non-covalently with a microfibril, any small fibril occurring in biological material. |
| nad+ adp-ribosyltransferase activity | Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. |
| ubiquitin-protein transferase inhibitor activity | Stops, prevents or reduces the activity of a ubiquitin-protein transferase. |
| methionine transmembrane transporter activity | Catalysis of the transfer of methionine from one side of a membrane to the other. |
| polynucleotide phosphatase activity | Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate. |
| hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. |
| atpase activator activity | Functions to increase the rate of ATP hydrolysis. |
| ketosteroid monooxygenase activity | Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate. |
| hydroxymethylglutaryl-coa reductase activity | Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH. |
| succinyltransferase activity | Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule. |
| nucleoside transmembrane transporter activity | Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. |
| guanylate cyclase inhibitor activity | Stops, prevents or reduces the activity of guanylate cyclase. |
| catechol o-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol. |
| rrna (uridine) methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine. |
| methylthioribulose 1-phosphate dehydratase activity | Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O. |
| ornithine carbamoyltransferase activity | Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. |
| udp-glucosyltransferase activity | Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule. |
| translation regulator activity, nucleic acid binding | Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. |
| leukotriene b4 receptor activity | Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate. |
| fad-amp lyase (cyclizing) activity | Catalysis of the reaction: FAD = AMP + riboflavin cyclic-4',5'-phosphate. |
| methylmalonyl-coa mutase activity | Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA. |
| neuromedin u receptor activity | Combining with neuromedin U to initiate a change in cell activity. |
| epoxide hydrolase activity | Catalysis of the reaction: an epoxide + H2O = a glycol. |
| lipid antigen binding | Interacting selectively and non-covalently with a lipid antigen. |
| mevalonate kinase activity | Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+). |
| sodium-exporting atpase activity, phosphorylative mechanism | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out); by a phosphorylative mechanism. |
| intronic transcription regulatory region dna binding | Interacting selectively and non-covalently with an intronic DNA region that regulates the transcription of the transcript it is contained within. |
| exoribonuclease activity, producing 5'-phosphomonoesters | Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. |
| peptidyl-asparagine 3-dioxygenase activity | Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2. |
| histone-arginine n-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine. |
| alcohol dehydrogenase (nad) activity | Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. |
| urea channel activity | Catalysis of facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| ligase activity, forming carbon-oxygen bonds | Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| cxcr3 chemokine receptor binding | Interacting selectively and non-covalently with a the CXCR3 chemokine receptor. |
| s-adenosylmethionine-dependent trna (m5u54) methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine at position U54 of a transfer RNA. This occurs in most Gram-negative bacteria, some archae, and eukaryotes. |
| natriuretic peptide receptor activity | Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity. |
| adenylate cyclase regulator activity | Modulates the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate. |
| manganese ion transmembrane transporter activity | Catalysis of the transfer of manganese (Mn) ions from one side of a membrane to the other. |
| mineralocorticoid receptor activity | Combining with a mineralocorticoid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. |
| low-affinity l-arginine transmembrane transporter activity | Catalysis of the transfer of L-arginine from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. |
| amylase activity | Catalysis of the hydrolysis of amylose or an amylose derivative. |
| alkylbase dna n-glycosylase activity | Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site. |
| procollagen-lysine 5-dioxygenase activity | Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2. |
| imidazolonepropionase activity | Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H(2)O = N-formimidoyl-L-glutamate + H(+). |
| n-acylneuraminate-9-phosphate synthase activity | Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate. |
| pyrimidine nucleotide transmembrane transporter activity | Catalysis of the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other. |
| oxidized dna binding | Interacting selectively and non-covalently with oxidized residues in DNA. |
| maltose alpha-glucosidase activity | Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose. |
| telomeric rna binding | Interacting selectively and non-covalently with the telomerase RNA template or to RNA complementary to it. |
| retinol dehydrogenase activity | Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. |
| steroid delta-isomerase activity | Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid. |
| phosphatidylinositol-5-phosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. |
| phosphomevalonate kinase activity | Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H(+). |
| protein dimerization activity | The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. |
| medium-chain-(s)-2-hydroxy-acid oxidase activity | Catalysis of the reaction: medium-chain-(S)-2-hydroxy-acid + O2 = medium-chain-2-oxo acid + hydrogen peroxide. Medium chain refers to a chain length of between 8 and 12 carbons. |
| mannose-6-phosphate isomerase activity | Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. |
| cgmp binding | Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). |
| glutamine-phenylpyruvate transaminase activity | Catalysis of the reaction: keto-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine. |
| cysteine-type endopeptidase inhibitor activity | Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| [acyl-carrier-protein] s-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]. |
| anion binding | Interacting selectively and non-covalently with anions, charged atoms or groups of atoms with a net negative charge. |
| atpase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. |
| isg15 activating enzyme activity | Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond. |
| thyrotropin-releasing hormone receptor binding | Interacting selectively and non-covalently with a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary. |
| dna-methyltransferase activity | Catalysis of the transfer of a methyl group to a DNA molecule. |
| toll-like receptor 4 binding | Interacting selectively and non-covalently with a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response. |
| peptide n-acetyltransferase activity | Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide. |
| hyaluronic acid binding | Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine. |
| sap kinase activity | Catalysis of the phosphorylation of proteins. A family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. Strongly activated by stress signals such as heat or osmotic shock, DNA-damaging agents, inhibitors of protein synthesis and pro-inflammatory cytokines. |
| maleylacetoacetate isomerase activity | Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate. |
| phosphoglucomutase activity | Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate. |
| cysteine-trna ligase activity | Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). |
| (r)-3-amino-2-methylpropionate-pyruvate transaminase activity | Catalysis of the reaction: (2R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine. |
| dynein complex binding | Interacting selectively and non-covalently with a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity. |
| histone methyltransferase activity (h4-k20 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein. |
| rna lariat debranching enzyme activity | Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide. |
| lim domain binding | Interacting selectively and non-covalently with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions. |
| udp-galactose:glucosylceramide beta-1,4-galactosyltransferase activity | Catalysis of the reaction: UDP-D-galactose + a glucosylceramide = a lactosylceramide + uridine-5'-diphosphate. The glucosylceramide has sphinganine as the long chain base. |
| naadp-sensitive calcium-release channel activity | Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts. |
| superoxide dismutase copper chaperone activity | A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity. |
| histone deacetylase activity (h3-k9 specific) | Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein. |
| p53 binding | Interacting selectively and non-covalently with one of the p53 family of proteins. |
| interleukin-12 alpha subunit binding | Interacting selectively and non-covalently with the alpha subunit of interleukin-12. |
| superoxide dismutase activity | Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide. |
| myosin vi light chain binding | Interacting selectively and non-covalently with a light chain of a myosin VI complex. |
| glucose-1,6-bisphosphate synthase activity | Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate + H(+). |
| leukotriene-a4 hydrolase activity | Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4). |
| map kinase activity | Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. |
| low-affinity glucose:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. |
| phosphocholine phosphatase activity | Catalysis of the reaction: choline phosphate + H2O = choline + phosphate. |
| glycerol channel activity | Catalysis of facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| telomerase inhibitor activity | Stops, prevents or reduces the activity of a telomerase. Telomerase catalyzes the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. |
| beta-1,3-galactosyl-o-glycosyl-glycoprotein beta-1,3-n-acetylglucosaminyltransferase activity | Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP. |
| exodeoxyribonuclease activity, producing 5'-phosphomonoesters | Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. |
| metalloenzyme inhibitor activity | Stops, prevents or reduces the activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal. |
| dna demethylase activity | Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule. |
| l-cystine l-cysteine-lyase (deaminating) | Catalysis of the reaction: L-cystine + H2O <=> pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide. |
| inward rectifier potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. |
| hydrolase activity, hydrolyzing n-glycosyl compounds | Catalysis of the hydrolysis of any N-glycosyl bond. |
| phosphatase binding | Interacting selectively and non-covalently with any phosphatase. |
| protein tyrosine kinase activator activity | Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein. |
| mannosyltransferase activity | Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
| transmembrane receptor protein tyrosine kinase activator activity | Increases the activity of a transmembrane receptor protein tyrosine kinase. |
| carbohydrate transporter activity | Enables the directed movement of carbohydrate into, out of or within a cell, or between cells. |
| ubiquitinated histone binding | Interacting selectively and non-covalently with a histone protein in which a residue has been modified by ubiquitination. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. |
| channel regulator activity | Modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. |
| 1-phosphatidylinositol-3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+). |
| thiamine transmembrane transporter activity | Catalysis of the transfer of thiamine from one side of the membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. |
| clathrin adaptor activity | The binding activity of a molecule that brings together clathrin and one or more other molecules, permitting them to function in a coordinated way. |
| luteinizing hormone receptor activity | Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity. |
| lipoate-protein ligase activity | Catalysis of the formation of carbon-nitrogen bonds between lipoate (5-(1,2-dithiolan-3-yl)pentanoate) and a protein. |
| atpase activity, coupled to transmembrane movement of substances | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane. |
| 5'-flap endonuclease activity | Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. |
| retinoic acid receptor activity | Combining with retinoic acid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. Retinoic acid is one of the forms of vitamin A. |
| ethanolamine-phosphate cytidylyltransferase activity | Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine. |
| chondroitin sulfate proteoglycan binding | Interacting selectively and non-covalently with a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit. |
| cytoskeletal adaptor activity | The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way. |
| histone kinase activity | Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. |
| uptake transmembrane transporter activity | Catalysis of the transfer of a specific substance or related group of substances from the outside of a cell to the inside across a membrane. |
| protein c-terminal s-isoprenylcysteine carboxyl o-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. |
| sodium:proton antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). |
| protein xylosyltransferase activity | Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate. |
| 1-phosphatidylinositol-3-kinase regulator activity | Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity. |
| beta-fructofuranosidase activity | Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside. |
| n-acetylneuraminate synthase activity | Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate. |
| trna (guanine-n1-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine. |
| oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound. |
| anti-mullerian hormone receptor activity | Combining with anti-Mullerian hormone to initiate a change in cell activity. |
| long-chain-acyl-coa dehydrogenase activity | Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF. |
| 5s rdna binding | Interacting selectively and non-covalently with the 5S rDNA sequence encoding ribosomal 5S rRNA, which is individually transcribed by RNA polymerase III, rather than by RNA polymerase I, in species where it exists. |
| ephrin receptor binding | Interacting selectively and non-covalently with an ephrin receptor. |
| n-acetylgalactosamine-4-sulfatase activity | Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. |
| inositol monophosphate 3-phosphatase activity | Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate. |
| interleukin-1, type i, activating receptor activity | Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins. |
| c5a anaphylatoxin chemotactic receptor binding | Interacting selectively and non-covalently with a C5a anaphylatoxin chemotactic receptor. |
| retinoic acid binding | Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. |
| thromboxane-a synthase activity | Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2). |
| kynurenine-oxoglutarate transaminase activity | Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. |
| beta-n-acetylgalactosaminidase activity | Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides. |
| endoribonuclease activity, producing 5'-phosphomonoesters | Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. |
| opsonin receptor activity | Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| filamin binding | Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. |
| phytanoyl-coa dioxygenase activity | Catalysis of the reaction: 2-oxoglutarate + O(2) + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO(2) + succinate. |
| annealing activity | A nucleic acid binding activity that brings together complementary sequences of nucleic acids so that they pair by hydrogen bonds to form a double-stranded polynucleotide. |
| 1,4-alpha-glucan branching enzyme activity | Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain. |
| gamma-glutamylcyclotransferase activity | Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid. |
| interleukin-27 receptor binding | Interacting selectively and non-covalently with the interleukin-27 receptor. |
| hsp90 protein binding | Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. |
| d-xylose 1-dehydrogenase (nadp+) activity | Catalysis of the reaction: D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH. |
| 3,4-dihydrocoumarin hydrolase activity | Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate. |
| cytoskeletal regulatory protein binding | Interacting selectively and non-covalently with any protein involved in modulating the reorganization of the cytoskeleton. |
| antibiotic transporter activity | Enables the directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of or within a cell, or between cells. |
| ciliary neurotrophic factor binding | Interacting selectively and non-covalently with the cytokine ciliary neurotrophic factor. |
| 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity | Catalysis of the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other. |
| tetrapyrrole binding | Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. |
| oxidized purine dna binding | Interacting selectively and non-covalently with oxidized purine residues in DNA. |
| bre binding | Interacting selectively and non-covalently with the RNA element BRE (Bruno response element). |
| transmembrane receptor protein phosphatase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. |
| epidermal growth factor receptor binding | Interacting selectively and non-covalently with the epidermal growth factor receptor. |
| ferric iron binding | Interacting selectively and non-covalently with ferric iron, Fe(III). |
| lys48-specific deubiquitinase activity | Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein. |
| peptide-transporting atpase activity | Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria. |
| n-acetylglucosaminylphosphatidylinositol deacetylase activity | Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane. |
| u6atac snrna binding | Interacting selectively and non-covalently with the U6atac small nuclear RNA (U6atac snRNA). |
| u7 snrna binding | Interacting selectively and non-covalently with the U7 small nuclear RNA (U7 snRNA). |
| o-fucosylpeptide 3-beta-n-acetylglucosaminyltransferase activity | Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor. |
| isocitrate dehydrogenase (nad+) activity | Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+. |
| h3k27me3 modified histone binding | Interacting selectively and non-covalently with a histone H3 in which the lysine residue at position 27 has been modified by trimethylation. |
| c-acyltransferase activity | Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule. |
| dynein light intermediate chain binding | Interacting selectively and non-covalently with a light intermediate chain of the dynein complex. |
| dopamine receptor binding | Interacting selectively and non-covalently with a dopamine receptor. |
| dna-(apurinic or apyrimidinic site) lyase activity | Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. |
| type 2a serotonin receptor binding | Interacting selectively and non-covalently with a type 2A serotonin receptor. |
| melanocyte-stimulating hormone receptor activity | Combining with melanocyte-stimulating hormone to initiate a change in cell activity. |
| ketoreductase activity | Catalysis of the reduction of a ketone group to form the corresponding alcohol. |
| nucleosomal dna binding | Interacting selectively and non-covalently with the DNA portion of a nucleosome. |
| glutathione binding | Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine. |
| alpha-mannosidase activity | Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. |
| phenylethanolamine n-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine. |
| thyroid hormone receptor activator activity | A receptor activator activity that binds to, thyroid hormone receptor in a ligand-dependent manner and enhances ligand-induced transcriptional activity of the receptor. |
| sphingolipid binding | Interacting selectively and non-covalently with sphingolipids, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). |
| argininosuccinate synthase activity | Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate. |
| fumarate hydratase activity | Catalysis of the reaction: (S)-malate = fumarate + H(2)O. |
| fucose binding | Interacting selectively and non-covalently with fucose, the pentose 6-deoxygalactose. |
| pyruvate secondary active transmembrane transporter activity | Catalysis of the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. |
| glycoprotein 6-alpha-l-fucosyltransferase activity | Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H(+). |
| single base insertion or deletion binding | Interacting selectively and non-covalently with double-stranded DNA containing a single base insertion or deletion. |
| dna (cytosine-5-)-methyltransferase activity, acting on cpg substrates | Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA). |
| arachidonic acid 14,15-epoxygenase activity | Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid. |
| farnesylated protein binding | Interacting selectively and non-covalently with a farnesylated protein. |
| oxygen binding | Interacting selectively and non-covalently with oxygen (O2). |
| cyclin-dependent protein kinase activating kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK). |
| dimethylglycine dehydrogenase activity | Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein. |
| histone methyltransferase binding | Interacting selectively and non-covalently with a histone methyltransferase enzyme. |
| calcium channel activity | Catalysis of facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| mirna binding | Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. |
| 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-coa hydratase activity | Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O. |
| pristanoyl-coa oxidase activity | Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide. |
| phosphatidylinositol-3,4,5-trisphosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions. |
| structural constituent of epidermis | The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure. |
| formate-tetrahydrofolate ligase activity | Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. |
| thrombospondin receptor activity | Combining with thrombospondin and transmitting the signal to initiate a change in cell activity. |
| g-protein coupled serotonin receptor binding | Interacting selectively and non-covalently with a metabotropic serotonin receptor. |
| calcium-release channel activity | Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
| nodal binding | Interacting selectively and non-covalently with a nodal protein, a member of the transforming growth factor-beta superfamily. |
| lysozyme activity | Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. |
| non-membrane spanning protein tyrosine phosphatase activity | Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. |
| nf-kappab binding | Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. |
| histone methyltransferase activity (h2a-r3 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H2A. |
| sialic acid transmembrane transporter activity | Catalysis of the transfer of sialic acid from one side of the membrane to the other. |
| phosphatidylinositol bisphosphate binding | Interacting selectively and non-covalently with phosphatidylinositol bisphosphate. |
| transmembrane receptor protein tyrosine kinase adaptor activity | The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way. |
| soluble nsf attachment protein activity | Interacting selectively and non-covalently with both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex. |
| cysteine-s-conjugate beta-lyase activity | Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate. |
| peptide transporter activity | Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells. |
| alpha-1b adrenergic receptor binding | Interacting selectively and non-covalently with an alpha-1B adrenergic receptor. |
| ion transmembrane transporter activity | Catalysis of the transfer of an ion from one side of a membrane to the other. |
| diamine oxidase activity | Catalysis of the reaction: a diamine + H2O + O2 = a monoamine + NH3 + hydrogen peroxide. |
| acetate ester transmembrane transporter activity | Catalysis of the transfer of an acetate ester from one side of the membrane to the other. |
| cmp-n-acetylneuraminate transmembrane transporter activity | Catalysis of the transfer of a CMP-N-acetylneuraminate from one side of the membrane to the other. |
| sumo transferase activity | Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages. |
| active transmembrane transporter activity | Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. |
| 25-hydroxycholesterol 7alpha-hydroxylase activity | Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O, and cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O. |
| protein-hormone receptor activity | Combining with a protein hormone to initiate a change in cell activity. |
| nitric-oxide synthase regulator activity | Modulates the activity of nitric oxide synthase. |
| glycine amidinotransferase activity | Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate. |
| flavin adenine dinucleotide binding | Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
| nerve growth factor receptor binding | Interacting selectively and non-covalently with the nerve growth factor receptor. |
| glucokinase activity | Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate. |
| dynein light chain binding | Interacting selectively and non-covalently with a light chain of the dynein complex. |
| cocaine binding | Interacting selectively and non-covalently with cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis. |
| alpha2-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein. |
| steroid hormone receptor activity | Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. |
| cation:amino acid symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in). |
| proteoglycan sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans. |
| dtdp-glucose 4,6-dehydratase activity | Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O. |
| inositol-1,4-bisphosphate 1-phosphatase activity | Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate. |
| cd40 receptor binding | Interacting selectively and non-covalently with CD40, a receptor found on the surface of all B-lymphocytes. |
| mannan binding | Interacting selectively and non-covalently with mannan. |
| transposase activity | Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. |
| n-acetylglucosamine-6-phosphate deacetylase activity | Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate. |
| dh domain binding | Interacting selectively and non-covalently with a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket. |
| nadph:quinone reductase activity | Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone. |
| receptor activator activity | The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased. |
| arsenite transmembrane transporter activity | Catalysis of the transfer of arsenite from one side of a membrane to the other. |
| hnk-1 sulfotransferase activity | Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R). |
| calcium- and calmodulin-responsive adenylate cyclase activity | Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin. |
| peptide-o-fucosyltransferase activity | Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor. |
| tyrosine-trna ligase activity | Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+). |
| flavin-linked sulfhydryl oxidase activity | Catalysis of the formation of disulfide bridges. |
| monovalent cation:proton antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out). |
| diuretic hormone activity | The action characteristic of a diuretic hormone, any peptide hormone that, upon receptor binding, regulates water balance and fluid secretion. |
| iron chaperone activity | Assists in the delivery of iron ions to target proteins or compartments. |
| lipoprotein lipase activity | Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein. |
| hexaprenyldihydroxybenzoate methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate. |
| insulin-like growth factor i binding | Interacting selectively and non-covalently with insulin-like growth factor I. |
| purine nucleoside transmembrane transporter activity | Catalysis of the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other. |
| peptidylglycine monooxygenase activity | Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O. |
| fructose-6-phosphate binding | Interacting selectively and non-covalently with fructose 6-phosphate. |
| glucose-6-phosphate isomerase activity | Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. |
| beta-carotene 15,15'-monooxygenase activity | Catalysis of the reaction: beta-carotene + O(2) = 2 retinal. |
| ctpase activity | Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction. |
| l-isoleucine transaminase activity | Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid. |
| krueppel-associated box domain binding | Interacting selectively and non-covalently with a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors. |
| translation repressor activity, nucleic acid binding | Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid. |
| cd4 receptor binding | Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages. |
| catecholamine binding | Interacting selectively and non-covalently with catecholamine. |
| aspartate 1-decarboxylase activity | Catalysis of the reaction: L-aspartate = beta-alanine + CO2. |
| rna polymerase ii transcription factor binding transcription factor activity involved in positive regulation of transcription | Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to increase the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. |
| diphosphoinositol-polyphosphate diphosphatase activity | Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate. |
| aquacobalamin reductase (nadph) activity | Catalysis of the reaction: 2 cob(II)alamin + NADP+ = 2 aquacob(III)alamin + NADPH + H+. |
| oxidoreductase activity, acting on ch or ch2 groups, nad or nadp as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
| arginine transmembrane transporter activity | Catalysis of the stereospecific transfer of arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane. |
| 3-hydroxyisobutyrate dehydrogenase activity | Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. |
| hexosaminidase activity | Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides. |
| jak pathway signal transduction adaptor activity | The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way. |
| transporter activity | Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. |
| mechanically gated channel activity | Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a mechanical stress. |
| netrin receptor activity | Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| aspartic-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. |
| dctp diphosphatase activity | Catalysis of the reaction: dCTP + H2O = dCMP + diphosphate. |
| small ribosomal subunit rrna binding | Interacting selectively and non-covalently with the small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA. |
| enoyl-coa hydratase activity | Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O. |
| n-acetylglucosaminyldiphosphodolichol n-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol. |
| rrna binding | Interacting selectively and non-covalently with ribosomal RNA. |
| citrate transmembrane transporter activity | Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. |
| c-acetyltransferase activity | Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule. |
| dihydrotestosterone 17-beta-dehydrogenase activity | Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH. |
| n-acetyl-l-aspartate-l-glutamate ligase activity | Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate. |
| rna polymerase iii type 2 promoter dna binding | Interacting selectively and non-covalently with a region of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs. |
| ap-3 adaptor complex binding | Interacting selectively and non-covalently with the AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B). |
| transmembrane receptor protein serine/threonine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| glycogen debranching enzyme activity | Catalysis of the cleavage of branch points in branched glycogen polymers. |
| 3'-5'-exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. |
| potassium-transporting atpase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). |
| histone acetyltransferase regulator activity | Modulates the activity of histone acetyltransferase. |
| 3-hydroxy-2-methylbutyryl-coa dehydrogenase activity | Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA. |
| prostanoid receptor binding | Interacting selectively and non-covalently with a prostanoid receptor. |
| hydroxypyruvate reductase activity | Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+. |
| ribonuclease e activity | Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. |
| protein n-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein. |
| phosphoethanolamine phosphatase activity | Catalysis of the reaction: O-phosphoethanolamine + H2O = ethanolamine + phosphate. |
| interleukin-21 receptor activity | Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| norepinephrine transmembrane transporter activity | Catalysis of the transfer of norepinephrine from one side of the membrane to the other. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. |
| adrenomedullin receptor binding | Interacting selectively and non-covalently with an adrenomedullin receptor. |
| narrow pore channel activity | Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated. |
| polyamine oxidase activity | Catalysis of the oxidative degradation or interconversion of polyamines. |
| adenylyltransferase activity | Catalysis of the transfer of an adenylyl group to an acceptor. |
| metal chelating activity | The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring. |
| cannabinoid receptor activity | Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids. |
| 1-phosphatidylinositol-5-phosphate 4-kinase activity | Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. |
| diphosphotransferase activity | Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor). |
| amino-acid betaine transmembrane transporter activity | Catalysis of the transfer of betaine, the N-trimethyl derivative of an amino acid, from one side of the membrane to the other. |
| atp-dependent dna/rna helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex. |
| opioid receptor activity | Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein. |
| intracellular ligand-gated calcium channel activity | Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. |
| glyceryl-ether monooxygenase activity | Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine). |
| type 1 parathyroid hormone receptor binding | Interacting selectively and non-covalently with a type 1 parathyroid hormone receptor. |
| voltage-gated potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| motor activity | Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. |
| 5,10-methylenetetrahydrofolate-dependent methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate. |
| apelin receptor binding | Interacting selectively and non-covalently with an apelin receptor. |
| caspase binding | Interacting selectively and non-covalently with a caspase family protein. |
| smad binding | Interacting selectively and non-covalently with a SMAD signaling protein. |
| microtubule-severing atpase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. |
| phosphatase inhibitor activity | Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. |
| satellite dna binding | Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA. |
| trehalase activity | Catalysis of the hydrolysis of trehalose or a trehalose derivative. |
| thiamine diphosphokinase activity | Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate. |
| histone acetyltransferase activity (h4-k8 specific) | Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8). |
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity | Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-3,4-bisphosphate + phosphate. |
| dihydrolipoyllysine-residue succinyltransferase activity | Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide. |
| cxcr5 chemokine receptor binding | Interacting selectively and non-covalently with a CXCR5 chemokine receptor. |
| uridylyltransferase activity | Catalysis of the transfer of an uridylyl group to an acceptor. |
| dna n-glycosylase activity | Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. |
| glucuronylgalactosylproteoglycan 4-beta-n-acetylgalactosaminyltransferase activity | Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP. |
| thyroid hormone binding | Interacting selectively and non-covalently with thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland. |
| sialic acid binding | Interacting selectively and non-covalently with sialic acid, any of a variety of N- or O- substituted derivatives of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria. |
| alkyl hydroperoxide reductase activity | Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol. |
| oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
| phosphatidylinositol bisphosphate kinase activity | Catalysis of the reaction: ATP + a phosphatidylinositol bisphosphate = ADP + a phosphatidylinositol trisphosphate. |
| snare binding | Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. |
| cytoskeletal protein binding | Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). |
| delta4-3-oxosteroid 5beta-reductase activity | Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+. |
| galactoside 2-alpha-l-fucosyltransferase activity | Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R. |
| transmembrane receptor protein kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. |
| diamine n-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine. |
| phosphorylase kinase activity | Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. |
| methylcytosine dioxygenase activity | Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2. |
| intramolecular transferase activity | Catalysis of the transfer of a functional group from one position to another within a single molecule. |
| galactolipase activity | Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates. |
| gtpase activity | Catalysis of the reaction: GTP + H2O = GDP + phosphate. |
| aldehyde-lyase activity | Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. |
| polypeptide n-acetylgalactosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis. |
| drug transporter activity | Enables the directed movement of a drug into, out of or within a cell, or between cells. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. |
| wnt-protein binding | Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling. |
| serum response element binding | Interacting selectively and non-covalently with the serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. |
| trimethylamine monooxygenase activity | Catalysis of the reaction: N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O. |
| l-aspartate transmembrane transporter activity | Catalysis of the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid. |
| glyceraldehyde oxidoreductase activity | Catalysis of the reaction: D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor. |
| transmitter-gated channel activity | Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts. |
| beta-3 adrenergic receptor binding | Interacting selectively and non-covalently with a beta-3 adrenergic receptor. |
| l-leucine transaminase activity | Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid. |
| aspartic-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. |
| vitamin d 25-hydroxylase activity | Catalysis of the hydroxylation of C-25 of any form of vitamin D. |
| transferase activity, transferring hexosyl groups | Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). |
| phospholipase d activity | Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. |
| ferrous iron binding | Interacting selectively and non-covalently with ferrous iron, Fe(II). |
| basal transcription machinery binding | Interacting selectively and non-covalently with the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase. |
| g-protein coupled adenosine receptor activity | Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| ribosomal protein s6 kinase activity | Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| organic cyclic compound binding | Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. |
| alkane 1-monooxygenase activity | Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O. |
| uridine nucleotide receptor activity | Combining with UTP or UDP to initiate a change in cell activity. |
| translation termination factor activity | Functions in the termination of translation. |
| structural constituent of cytoskeleton | The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. |
| acetylpyruvate hydrolase activity | Catalysis of the reaction: acetylpyruvate + H(2)O = acetate + H(+) + pyruvate. |
| immunoglobulin binding | Interacting selectively and non-covalently with an immunoglobulin. |
| enzyme inhibitor activity | Stops, prevents or reduces the activity of an enzyme. |
| homogentisate 1,2-dioxygenase activity | Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+). |
| apolipoprotein receptor binding | Interacting selectively and non-covalently with an apolipoprotein receptor. |
| ubiquitin-protein transferase activator activity | Increases the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein. |
| gonadotropin-releasing hormone receptor activity | Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. |
| zinc ion binding | Interacting selectively and non-covalently with zinc (Zn) ions. |
| citrate (si)-synthase activity | Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group. |
| ankyrin binding | Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. |
| four-way junction dna binding | Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. |
| lactosylceramide alpha-2,3-sialyltransferase activity | Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3. |
| dihydroceramidase activity | Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine. |
| microtubule plus-end binding | Interacting selectively and non-covalently with the plus end of a microtubule. |
| growth factor activity | The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. |
| ubiquitin-protein transferase regulator activity | Modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein. |
| carnitine transmembrane transporter activity | Enables the directed movement of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. |
| structural constituent of cell wall | The action of a molecule that contributes to the structural integrity of a cell wall. |
| growth hormone secretagogue receptor activity | Combining with ghrelin to initiate a change in cell activity. |
| c-palmitoyltransferase activity | Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule. |
| prolactin receptor activity | Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| sodium:sulfate symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in). |
| hydroxymethylglutaryl-coa reductase (nadph) activity | Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH. |
| s-malonyltransferase activity | Catalysis of the transfer of a malonyl group to a sulfur atom on the acceptor molecule. |
| adenylate cyclase binding | Interacting selectively and non-covalently with the enzyme adenylate cyclase. |
| low-affinity basic amino acid transmembrane transporter activity | Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. |
| lead ion transmembrane transporter activity | Catalysis of the transfer of lead (Pb) ions from one side of a membrane to the other. |
| copper-exporting atpase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) -> ADP + phosphate + Cu2+(out). |
| interleukin-13 receptor activity | Combining with interleukin-13 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| ctp:trna cytidylyltransferase activity | Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' cytidine end + diphosphate. |
| monophenol monooxygenase activity | Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O. |
| ligase activity, forming carbon-nitrogen bonds | Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| nucleoside diphosphate kinase activity | Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. |
| chaperone binding | Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. |
| protein complex scaffold | Functions to provide a physical support for the assembly of a multiprotein complex. |
| proline-trna ligase activity | Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). |
| atp-dependent microtubule motor activity, plus-end-directed | |
| dopamine neurotransmitter receptor activity, coupled via gi/go | Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity. |
| glycine n-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine. |
| nedd8 activating enzyme activity | Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade. |
| activin receptor activity, type i | Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals. |
| calmodulin-dependent protein kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin. |
| atp-dependent dna helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix. |
| choriogonadotropin hormone receptor activity | Combining with the choriogonadotropin hormone to initiate a change in cell activity. |
| c5a anaphylatoxin receptor activity | Combining with anaphylatoxin C5a to initiate a change in cell activity. |
| type iii transforming growth factor beta receptor binding | Interacting selectively and non-covalently with a type III transforming growth factor beta receptor. |
| 5'-3' dna/rna helicase activity | Catalysis of the unwinding of a DNA/RNA duplex in the direction 5' to 3'. |
| oxidoreductase activity, acting on nad(p)h, heme protein as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein. |
| alpha-n-acetylgalactosaminide alpha-2,6-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein. |
| formyltetrahydrofolate dehydrogenase activity | Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO(2) + H(+) + NADPH. |
| sterol esterase activity | Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid. |
| alpha-(1,2)-fucosyltransferase activity | Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage. |
| phosphatidylserine 1-acylhydrolase activity | Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid. |
| icam-3 receptor activity | Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues. |
| isopeptidase activity | Catalysis of the hydrolysis of an isopeptide bond. An isopeptide bond is an amide linkage between a carboxyl group of one amino acid and an amino group of another amino acid in which at least one of these groups is not on the a-carbon of one of the amino acids (for example, the link between an epsilon-amino group of a lysine molecule to a carboxyl group on a second amino acid is an isopeptide bond). |
| s-adenosylmethionine-homocysteine s-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine. |
| interleukin-4 receptor activity | Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| phosphatidylinositol transporter activity | Enables the directed movement of phosphatidylinositol into, out of or within a cell, or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
| gap junction channel activity involved in cardiac conduction electrical coupling | A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction. |
| 1-alkylglycerophosphocholine o-acetyltransferase activity | Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA. |
| propane-1,3-diamine oxidase activity | Catalysis of the reaction: propane-1,3-diamine + H2O + O2 = 3-aminopropanal + NH3 + hydrogen peroxide + H+. |
| formate efflux transmembrane transporter activity | Catalysis of the transfer of formate from the inside of the cell to the outside of the cell across a membrane. |
| passive transmembrane transporter activity | Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient. |
| rna helicase activity | Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix. |
| transferase activity, transferring selenium-containing groups | Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor). |
| 17-beta-hydroxysteroid dehydrogenase (nad+) activity | Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+. |
| beta-mannosidase activity | Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. |
| myosin vi binding | Interacting selectively and non-covalently with a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments. |
| inositol phosphate phosphatase activity | Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate. |
| inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity | Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+. |
| d-serine ammonia-lyase activity | Catalysis of the reaction: D-serine = pyruvate + NH3. |
| l-tyrosine:2-oxoglutarate aminotransferase activity | Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate. |
| atp-dependent microtubule motor activity, minus-end-directed | |
| c2h2 zinc finger domain binding | Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion. |
| oncostatin-m receptor binding | Interacting selectively and non-covalently with the oncostatin-M receptor. |
| mo-molybdopterin cofactor sulfurase activity | Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase. |
| laminin-1 binding | Interacting selectively and non-covalently with laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1. |
| polynucleotide 5'-hydroxyl-kinase activity | Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. |
| hydroxyapatite binding | Interacting selectively and non-covalently with hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentin. |
| 5-methyltetrahydrofolate-dependent methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate. |
| lactosylceramide 4-alpha-galactosyltransferase activity | Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP. |
| cofactor binding | Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. |
| hydrolase activity, acting on glycosyl bonds | Catalysis of the hydrolysis of any glycosyl bond. |
| melanocortin receptor activity | Combining with melanocortin to initiate a change in cell activity. |
| coa hydrolase activity | Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. |
| glycogenin glucosyltransferase activity | Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. |
| sodium-dependent organic anion transmembrane transporter activity | Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner. |
| lipase activator activity | Increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. |
| structural constituent of cutaneous appendage | The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers. |
| dolichyl pyrophosphate man9glcnac2 alpha-1,3-glucosyltransferase activity | Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. |
| monovalent inorganic cation transmembrane transporter activity | Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. |
| ligase activity, forming aminoacyl-trna and related compounds | Catalysis of the joining of an amino acid and a nucleic acid (usually tRNA) or poly(ribitol phosphate), with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. The reaction forms an aminoacyl-tRNA or a related compound. |
| estrogen-activated sequence-specific dna binding rna polymerase ii transcription factor activity | Combining with estrogen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. |
| urokinase plasminogen activator receptor activity | Combining with the urokinase plasminogen activator to initiate a change in cell activity. |
| corticotropin receptor activity | Combining with corticotropin to initiate a change in cell activity. |
| coumarin 7-hydroxylase activity | Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. |
| pancreatic ribonuclease activity | Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. |
| interleukin-11 binding | Interacting selectively and non-covalently with interleukin-11. |
| hemoglobin alpha binding | Interacting selectively and non-covalently with a hemoglobin alpha chain. |
| glucose-6-phosphatase activity | Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate. |
| peptidyl-proline dioxygenase activity | Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2. |
| purine ntp-dependent helicase activity | Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate, to drive the unwinding of a DNA or RNA helix. |
| a2a adenosine receptor binding | Interacting selectively and non-covalently with an A2A adenosine receptor. |
| atp-dependent protein binding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP. |
| cyclin-dependent protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). |
| alkaline phosphatase activity | Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. |
| alpha-1,3-mannosylglycoprotein 4-beta-n-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R. |
| nadph dehydrogenase (quinone) activity | |
| type 1 melanocortin receptor binding | Interacting selectively and non-covalently with a type 1 melanocortin receptor. |
| ceramide transporter activity | Enables the directed movement of ceramides into, out of or within a cell, or between cells. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid. |
| pyrimidine deoxyribonucleotide binding | Interacting selectively and non-covalently with a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety. |
| glycerone kinase activity | Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+). |
| double-stranded dna 3'-5' exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule. |
| map-kinase scaffold activity | The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently. |
| macrophage colony-stimulating factor receptor activity | Combining with macrophage colony-stimulating factor (M-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
| adp transmembrane transporter activity | Catalysis of the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other. |
| allantoicase activity | Catalysis of the reaction: allantoate + H(2)O = (S)-ureidoglycolate + urea. |
| substance k receptor activity | Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity. |
| macrophage colony-stimulating factor receptor binding | Interacting selectively and non-covalently with the macrophage colony-stimulating factor receptor. |
| structure-specific dna binding | Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding. |
| phosphopantothenoylcysteine decarboxylase activity | Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H(+) = CO(2) + pantetheine 4'-phosphate. |
| kringle domain binding | Interacting selectively and non-covalently with a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors. |
| atpase activity, coupled to movement of substances | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance. |
| sumo polymer binding | Interacting selectively and non-covalently with a polymer of the small ubiquitin-like protein SUMO. |
| eoxin a4 synthase activity | Catalysis of the reaction: leukotriene A4 = eoxin A4. |
| s-formylglutathione hydrolase activity | Catalysis of the reaction: S-formylglutathione + H(2)O = formate + glutathione + H(+). |
| interleukin-28 receptor binding | Interacting selectively and non-covalently with the interleukin-28 receptor. |
| inhibin binding | Interacting selectively and non-covalently with an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers. |
| ubiquitin-like protein ligase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-SCP + Y --> Y-SCP + X, where both X-SCP and Y-SCP are covalent linkages. SCP represents a small conjugating protein. |
| dna topoisomerase activity | Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. |
| translation initiation factor binding | Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation. |
| neurotransmitter binding | Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. |
| chloride-transporting atpase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cl-(out) = ADP + phosphate + Cl-(in). |
| acid-thiol ligase activity | Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| protein-disulfide reductase activity | Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+. |
| urea transmembrane transporter activity | Enables the directed movement of urea cross a membrane into, out of or within a cell, or between cells. Urea is the water soluble compound H2N-CO-NH2. |
| receptor inhibitor activity | The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased. |
| host cell surface binding | Interacting selectively and non-covalently with the surface of a host cell. |
| i-smad binding | Interacting selectively and non-covalently with an inhibitory SMAD signaling protein. |
| palmitoyl-[acyl-carrier-protein] hydrolase activity | Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate. |
| dehydroascorbic acid transporter activity | Enables the directed movement of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| n-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity | Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP. |
| phenanthrene-epoxide hydrolase activity | Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene. |
| nucleotide phosphatase activity, acting on free nucleotides | Catalysis of the reaction: nucleotide + H2O = nucleotide + phosphate. |
| phosphatidylinositol phosphate binding | Interacting selectively and non-covalently with phosphatidylinositol phosphate. |
| nfat protein binding | Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system. |
| amp binding | Interacting selectively and non-covalently with AMP, adenosine monophosphate. |
| trna dihydrouridine synthase activity | Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. |
| electron carrier activity | Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. |
| ribonuclease activity | Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. |
| 5'-3' rna helicase activity | Catalysis of the unwinding of an RNA helix in the direction 5' to 3'. |
| oxidoreductase activity, acting on the ch-ch group of donors, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen. |
| f-box domain binding | Interacting selectively and non-covalently with an F-box domain of a protein. |
| y-form dna binding | Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end. |
| galactose binding | Interacting selectively and non-covalently with the aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides. |
| tyrosine 3-monooxygenase activity | Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. |
| ligand-gated sodium channel activity | Catalysis of the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
| lipoate synthase activity | Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl. |
| trna (guanine(37)-n(1))-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine. |
| adenyl deoxyribonucleotide binding | Interacting selectively and non-covalently with an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety. |
| thyroid hormone receptor coactivator activity | The function of a transcription cofactor that activates transcription in conjunction with a thyroid hormone-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself. |
| 5-oxo-6e,8z,11z,14z-icosatetraenoic acid binding | Interacting selectively and non-covalently with 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. |
| mh2 domain binding | Interacting selectively and non-covalently with the MH2 (MAD homology 2) domain of a protein. The MH2 domain is found at the carboxy terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. |
| nad-dependent histone deacetylase activity (h3-k18 specific) | Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein. |
| glutaminyl-trna synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP. |
| aspartate n-acetyltransferase activity | Catalysis of the reaction: L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H(+). |
| thiol oxidase activity | Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O. |
| peptidylamidoglycolate lyase activity | Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate. |
| pyrimidine ribonucleoside binding | Interacting selectively and non-covalently with a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose. |
| voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| utp-monosaccharide-1-phosphate uridylyltransferase activity | Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide. |
| histone tyrosine kinase activity | Catalysis of the transfer of a phosphate group to a tyrosine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. |
| thymidine phosphorylase activity | Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. |
| histone acetyltransferase activity (h4-k16 specific) | Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4. |
| g-protein coupled photoreceptor activity | Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| nicotinamide-nucleotide adenylyltransferase activity | Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+. |
| protein adenylyltransferase activity | Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to specific residues of target proteins. |
| long-chain fatty acid transporter activity | Enables the directed movement of long-chain fatty acids into, out of or within a cell, or between cells. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
| n-acetylneuraminate lyase activity | Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate. |
| 1-acyl-2-lysophosphatidylserine acylhydrolase activity | Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate. |
| sterol 14-demethylase activity | Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O. |
| thromboxane receptor activity | Combining with a thromboxane (TXA) to initiate a change in cell activity. |
| receptor signaling protein serine/threonine kinase activity | Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| very-low-density lipoprotein particle receptor binding | Interacting selectively and non-covalently with a very-low-density lipoprotein receptor. |
| low-density lipoprotein receptor activity | Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein into the cell via endocytosis. |
| udp-galactose:beta-n-acetylglucosamine beta-1,3-galactosyltransferase activity | Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP. |
| arachidonate 12-lipoxygenase activity | Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate. |
| purine-rich negative regulatory element binding | Interacting selectively and non-covalently with a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes. |
| potassium channel regulator activity | Modulates the activity of a potassium channel. |
| tumor necrosis factor receptor binding | Interacting selectively and non-covalently with the tumor necrosis factor receptor. |
| gmp binding | Interacting selectively and non-covalently with GMP, guanosine monophosphate. |
| inositol bisphosphate phosphatase activity | Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate. |
| apolipoprotein a-i binding | Interacting selectively and non-covalently with apolipoprotein A-I. |
| cholate 7-alpha-dehydrogenase activity | Catalysis of the reaction: cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH. |
| threonine racemase activity | Catalysis of the reaction: L-threonine = D-threonine. |
| melatonin receptor activity | Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin. |
| heteroduplex dna loop binding | Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration. |
| neuropeptide y receptor activity | Combining with neuropeptide Y to initiate a change in cell activity. |
| phosphoribosylamine-glycine ligase activity | Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate. |
| interleukin-10 binding | Interacting selectively and non-covalently with interleukin-10. |
| pre-mrna intronic pyrimidine-rich binding | Interacting selectively and non-covalently with a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA). |
| amine n-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. |
