| Description | Curated annotations of genes with molecular functions |
| Measurement | association by literature curation |
| Association | gene-molecular function associations from curated gene annotations |
| Category | structural or functional annotations |
| Resource | Gene Ontology |
| Citation(s) | |
| Last Updated | 2015 Mar 31 |
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Gene Attribute
Gene Similarity
Attribute Similarity
UMAP
3851 sets of genes performing molecular functions from the curated GO Molecular Function Annotations 2023 dataset.
| Gene Set | Description |
|---|---|
| aromatase activity | Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. |
| MHC protein binding | Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. |
| protein homodimerization activity | Interacting selectively and non-covalently with an identical protein to form a homodimer. |
| ATPase binding | Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
| mRNA 3'-UTR binding | Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S --> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate. Note that this may include the extension of ubiquitin chains. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II. |
| cis-regulatory region sequence-specific DNA binding | Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon. |
| DNA-binding transcription repressor activity, RNA polymerase II-specific | Interacting selectively and non-covalently with a sequence of DNA that is in the regulatory region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| sequence-specific double-stranded DNA binding | |
| calcium ion binding | Interacting selectively and non-covalently with calcium ions (Ca2+). |
| calcium-dependent phospholipid binding | Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. |
| phosphatidylethanolamine binding | Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. |
| phosphatidylinositol binding | Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| cadherin binding | Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion. |
| solute:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in). |
| mitochondrial ribosome binding | Interacting selectively and non-covalently with any part of a mitochondrial ribosome, a ribosome found in the mitochondrion of a eukaryotic cell. |
| magnesium ion binding | Interacting selectively and non-covalently with magnesium (Mg) ions. |
| UDP-xylosyltransferase activity | Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule. |
| monoatomic ion channel activity | Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| GTPase activator activity | Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + phosphate. |
| protein kinase binding | Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein serine/threonine kinase activator activity | Increases the activity of a protein serine/threonine kinase. |
| CARD domain binding | Interacting selectively and non-covalently with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family. |
| BH3 domain binding | Interacting selectively and non-covalently with the BH3 domain of a protein of the Bcl-2 family. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death. |
| intracellular calcium activated chloride channel activity | Catalysis of the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. |
| heme binding | Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. |
| ubiquitin conjugating enzyme activity | Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. |
| actin binding | Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. |
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
| fatty acid elongase activity | Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C). |
| phosphatidylinositol-5-phosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. |
| phosphatidylinositol-3-phosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. |
| SH2 domain binding | Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. |
| phosphatidylinositol-3,5-bisphosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions. |
| ADP-ribosylglutamate hydrolase activity | |
| threonine-tRNA ligase activity | Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). |
| hydroxylysine kinase activity | Catalysis of the reaction: erythro-5-hydroxy-L-lysine + GTP = 5-phosphonooxy-L-lysine + GDP + 2 H(+). |
| microtubule binding | Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. |
| tRNA binding | Interacting selectively and non-covalently with transfer RNA. |
| iron ion binding | Interacting selectively and non-covalently with iron (Fe) ions. |
| tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity | |
| calcium oxalate binding | Interacting selectively and non-covalently with calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi. |
| racemase and epimerase activity, acting on carbohydrates and derivatives | Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. |
| L-fucose mutarotase activity | |
| fucose binding | Interacting selectively and non-covalently with fucose, the pentose 6-deoxygalactose. |
| D-ribitol-5-phosphate cytidylyltransferase activity | |
| cytidylyltransferase activity | Catalysis of the transfer of a cytidylyl group to an acceptor. |
| amyloid-beta binding | Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor. |
| phosphatidylinositol 3-kinase regulator activity | Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
| RNA endonuclease activity | Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. |
| metal ion binding | Interacting selectively and non-covalently with any metal ion. |
| plasmanylethanolamine desaturase activity | |
| serotonin-gated monoatomic cation-selective channel activity | |
| poly(A)-specific ribonuclease activity | Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. |
| nuclear estrogen receptor binding | Interacting selectively and non-covalently with an estrogen receptor. |
| nuclear retinoic acid receptor binding | Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. |
| armadillo repeat domain binding | Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation. |
| carnosine synthase activity | Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine. |
| homocarnosine synthase activity | |
| DNA-binding transcription activator activity, RNA polymerase II-specific | Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. |
| protein tyrosine phosphatase activity | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| phosphoglycolate phosphatase activity | Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate. |
| glycerol-3-phosphatase activity | |
| metalloendopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| carboxy-lyase activity | Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. |
| arginine binding | Interacting selectively and non-covalently with 2-amino-5-(carbamimidamido)pentanoic acid. |
| sequence-specific DNA binding | Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| rRNA (cytosine-N4-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine. |
| aconitate decarboxylase activity | Catalysis of the reaction: cis-aconitate + H(+) = CO(2) + itaconate. |
| hormone activity | The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. |
| ionotropic glutamate receptor binding | Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. |
| GABA receptor binding | Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. |
| olfactory receptor activity | Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. |
| tubulin-glutamic acid ligase activity | Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule. |
| NAD-retinol dehydrogenase activity | Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. |
| cysteine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| cysteine-type deubiquitinase activity | Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin. |
| K63-linked deubiquitinase activity | Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein. |
| K48-linked deubiquitinase activity | Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein. |
| protein-glycine ligase activity, initiating | Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein. |
| ubiquitin ligase-substrate adaptor activity | |
| mRNA binding | Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| ubiquitin protein ligase binding | Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. |
| alpha-tubulin binding | Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin. |
| peptidase inhibitor activity | Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. |
| chloride channel activity | Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| phosphatase binding | Interacting selectively and non-covalently with any phosphatase. |
| GABA-A receptor activity | Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels. |
| double-stranded DNA binding | Interacting selectively and non-covalently with double-stranded DNA. |
| lactose binding | Interacting selectively and non-covalently with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk. |
| lysine N-methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. |
| protein-lysine N-methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. |
| methylation-dependent protein binding | |
| BMP receptor binding | Interacting selectively and non-covalently with a BMP receptor. |
| CoA pyrophosphatase activity | |
| potassium channel activity | Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| phosphatidylinositol-4,5-bisphosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. |
| phosphatidylinositol-3,4,5-trisphosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions. |
| phosphatidylinositol-3,4-bisphosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions. |
| endothelin receptor activity | Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| vascular endothelial growth factor binding | Interacting selectively and non-covalently with a vascular endothelial growth factor. |
| 3-hydroxyacyl-CoA dehydratase activity | Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA). |
| SH3 domain binding | Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. |
| histone H3K9me2/H3K9me3 demethylase activity | |
| immunoglobulin receptor binding | Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule. |
| inward rectifier potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. |
| voltage-gated monoatomic anion channel activity | Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| estradiol 17-beta-dehydrogenase [NAD(P)] activity | Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. |
| cytokine activity | Functions to control the survival, growth, differentiation and effector function of tissues and cells. |
| alkylglycerone-phosphate synthase activity | Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion. |
| FAD binding | Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| calcium channel regulator activity | Modulates the activity of a calcium channel. |
| potassium channel regulator activity | Modulates the activity of a potassium channel. |
| sodium channel regulator activity | Modulates the activity of a sodium channel. |
| chloride channel regulator activity | Modulates the activity of a chloride channel. |
| deoxycytidine kinase activity | Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP. |
| thymidine kinase activity | Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. |
| nucleoside kinase activity | Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. |
| Wnt receptor activity | Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| protein heterodimerization activity | Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. |
| cadherin binding involved in cell-cell adhesion | |
| fatty-acyl-CoA binding | Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. |
| palmitoyl-CoA hydrolase activity | Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate. |
| long-chain fatty acyl-CoA binding | Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more. |
| small GTPase binding | Interacting selectively and non-covalently with a small monomeric GTPase. |
| ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| syntaxin binding | Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. |
| interleukin-1 binding | Interacting selectively and non-covalently with interleukin-1. |
| histone H2AXY142 phosphatase activity | |
| GAF domain binding | Interacting selectively and non-covalently with the GAF domain of a protein. |
| chemokine activity | The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. |
| CCR3 chemokine receptor binding | |
| receptor ligand activity | Interacts with receptors such that the proportion of receptors in the active form is increased. |
| voltage-gated potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| sodium channel activity | Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| potassium ion leak channel activity | Catalysis of the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state. |
| galactose binding | Interacting selectively and non-covalently with the aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides. |
| disaccharide binding | Interacting selectively and non-covalently with any disaccharide. Disaccharides are sugars composed of two monosaccharide units. |
| complement component C4b binding | Interacting selectively and non-covalently with the C4b product of the classical complement cascade. |
| serine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| GTP binding | Interacting selectively and non-covalently with GTP, guanosine triphosphate. |
| GDP binding | Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate. |
| myosin V binding | Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. |
| protein phosphatase binding | Interacting selectively and non-covalently with any protein phosphatase. |
| cholesterol binding | Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
| steroid sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate. |
| lipopolysaccharide immune receptor activity | Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. |
| low-density lipoprotein particle receptor binding | Interacting selectively and non-covalently with a low-density lipoprotein receptor. |
| NADH dehydrogenase activity | Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. |
| NADH dehydrogenase (ubiquinone) activity | Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. |
| hyaluronan synthase activity | Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP. |
| protease binding | Interacting selectively and non-covalently with any protease or peptidase. |
| death receptor activity | Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death. |
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| glutamate receptor activity | Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| G protein-coupled receptor binding | Interacting selectively and non-covalently with a G-protein coupled receptor. |
| neuropeptide hormone activity | The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. |
| bHLH transcription factor binding | Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
| transmembrane receptor protein serine/threonine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| copper ion binding | Interacting selectively and non-covalently with copper (Cu) ions. |
| cuprous ion binding | Interacting selectively and non-covalently with cuprous ion, copper(1+). |
| phosphatidylinositol phospholipase C activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+). |
| four-way junction DNA binding | Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. |
| Y-form DNA binding | Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end. |
| transcription cis-regulatory region binding | Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
| R-SMAD binding | Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein. |
| SUMO transferase activity | Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages. |
| SUMO binding | Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO. |
| SUMO ligase activity | Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S --> X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate. |
| core promoter sequence-specific DNA binding | Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. |
| aryl hydrocarbon receptor binding | Interacting selectively and non-covalently with an aryl hydrocarbon receptor. |
| arachidonic acid binding | Interacting selectively and non-covalently with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. |
| deoxyribonuclease inhibitor activity | |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
| epidermal growth factor receptor binding | Interacting selectively and non-covalently with the epidermal growth factor receptor. |
| clathrin light chain binding | Interacting selectively and non-covalently with a clathrin light chain. |
| glutamate receptor binding | Interacting selectively and non-covalently with a glutamate receptor. |
| clathrin adaptor activity | The binding activity of a molecule that brings together clathrin and one or more other molecules, permitting them to function in a coordinated way. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
| metal-dependent deubiquitinase activity | |
| voltage-gated calcium channel activity | Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| high voltage-gated calcium channel activity | Catalysis of the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. |
| RNA polymerase II-specific DNA-binding transcription factor binding | Interacting selectively and non-covalently with a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. |
| kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| Hsp90 protein binding | Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. |
| E-box binding | Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. |
| DNA-binding transcription factor binding | |
| 1-phosphatidylinositol-3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+). |
| phosphatidylinositol 3-kinase activity | Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring. |
| pyruvate dehydrogenase (NAD+) activity | |
| purine nucleobase transmembrane transporter activity | Catalysis of the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other. |
| nucleoside:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in). |
| cytidine transmembrane transporter activity | |
| uridine transmembrane transporter activity | |
| pyrimidine- and adenosine-specific:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenine)(out) + Na+(out) = (pyrimidine nucleoside or adenine)(in) + Na+(in). |
| aryl sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. |
| sulfotransferase activity | Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. |
| L-glutamate transmembrane transporter activity | Catalysis of the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid. |
| high-affinity L-glutamate transmembrane transporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + H+(out) = glutamate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. |
| extracellularly glutamate-gated chloride channel activity | |
| glutamate:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in). |
| flavin-linked sulfhydryl oxidase activity | Catalysis of the formation of disulfide bridges. |
| acetyl-CoA transmembrane transporter activity | Enables the directed movement of acetyl-CoA into, out of or within a cell, or between cells. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. |
| GTPase regulator activity | Modulates the rate of GTP hydrolysis by a GTPase. |
| 3',5'-cyclic-AMP phosphodiesterase activity | Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. |
| cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP. |
| zinc ion binding | Interacting selectively and non-covalently with zinc (Zn) ions. |
| cAMP binding | Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). |
| cGMP binding | Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). |
| TPR domain binding | Interacting selectively and non-covalently with a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices. |
| phosphate ion binding | Interacting selectively and non-covalently with phosphate. |
| 3',5'-cyclic-GMP phosphodiesterase activity | Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. |
| GTPase inhibitor activity | Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. |
| 3'-5'-RNA exonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. |
| DNA primase activity | Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase. |
| DNA-directed 5'-3' RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| elongation factor-2 kinase activity | |
| chemokine receptor binding | Interacting selectively and non-covalently with any chemokine receptor. |
| CCR chemokine receptor binding | Interacting selectively and non-covalently with a CCR chemokine receptor. |
| tubulin binding | Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules. |
| mRNA 5'-UTR binding | Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule. |
| N6-methyladenosine-containing RNA binding | Interacting selectively and non-covalently with an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs. |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+). |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+). |
| phosphotyrosine residue binding | Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein. |
| receptor tyrosine kinase binding | Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity. |
| beta-mannosidase activity | Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. |
| thioesterase binding | Interacting selectively and non-covalently with any thioesterase enzyme. |
| procollagen-lysine 5-dioxygenase activity | Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2. |
| sodium:phosphate symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in). |
| urate transmembrane transporter activity | Catalysis of the transfer of urate from one side of the membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. |
| transcription coregulator binding | Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. |
| metallopeptidase activity | Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| endopeptidase activator activity | Increases the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. |
| preribosome binding | |
| aspartic-type endopeptidase inhibitor activity | Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process. |
| tau protein binding | Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. |
| RNA polymerase binding | Interacting selectively and non-covalently with an RNA polymerase molecule or complex. |
| cysteine-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| co-SMAD binding | Interacting selectively and non-covalently with a common mediator SMAD signaling protein. |
| fatty acid amide hydrolase activity | Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid. |
| acylglycerol lipase activity | Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol. |
| Notch binding | Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor. |
| Tat protein binding | Interacting selectively and non-covalently with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus. |
| peptidase activator activity involved in apoptotic process | Increases the activity of a peptidase that is involved in the apoptotic process. |
| frizzled binding | Interacting selectively and non-covalently with the frizzled (fz) receptor. |
| interleukin-5 receptor binding | Interacting selectively and non-covalently with the interleukin-5 receptor. |
| syndecan binding | Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells. |
| phosphatidylinositol transfer activity | Enables the directed movement of phosphatidylinositol into, out of or within a cell, or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
| phosphatidic acid binding | Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. |
| snoRNA binding | Interacting selectively and non-covalently with small nucleolar RNA. |
| histone methyltransferase binding | Interacting selectively and non-covalently with a histone methyltransferase enzyme. |
| poly(A) binding | Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. |
| eukaryotic initiation factor 4E binding | Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation. |
| ribonucleoside triphosphate phosphatase activity | Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. |
| RNA strand annealing activity | |
| RNA stem-loop binding | Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop. |
| gamma-tubulin binding | Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin. |
| ribosomal small subunit binding | Interacting selectively and non-covalently with any part of the small ribosomal subunit. |
| CTPase activity | Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction. |
| RNA nuclease activity | Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. |
| CCR7 chemokine receptor binding | Interacting selectively and non-covalently with a CCR7 chemokine receptor. |
| O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity | Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor. |
| chemokine receptor activity | Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. |
| ubiquitin ligase activator activity | |
| quercetin 2,3-dioxygenase activity | Catalysis of the reaction: H(+) + O(2) + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO. |
| peroxisome matrix targeting signal-2 binding | Interacting selectively and non-covalently with a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F). |
| protein serine/threonine phosphatase activity | Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. |
| cardiolipin binding | Interacting selectively and non-covalently with cardiolipin. |
| carboxylesterase activity | |
| ubiquitin-like protein ligase binding | |
| acetyl-CoA carboxylase activity | Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. |
| pyridoxal kinase activity | Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. |
| pyridoxal phosphate binding | Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
| potassium ion binding | Interacting selectively and non-covalently with potassium (K+) ions. |
| sodium ion binding | Interacting selectively and non-covalently with sodium ions (Na+). |
| lithium ion binding | Interacting selectively and non-covalently with lithium ions (Li+). |
| stearoyl-CoA 9-desaturase activity | Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O. |
| diacylglycerol diphosphate phosphatase activity | |
| phosphatidate phosphatase activity | Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. |
| sphingosine-1-phosphate phosphatase activity | Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate. |
| lipid phosphatase activity | Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate. |
| ceramide-1-phosphate phosphatase activity | |
| nuclear receptor binding | Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein. |
| MRF binding | Interacting selectively and non-covalently with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors. |
| growth hormone receptor binding | Interacting selectively and non-covalently with the growth hormone receptor. |
| insulin-like growth factor receptor binding | Interacting selectively and non-covalently with the insulin-like growth factor receptor. |
| JAK pathway signal transduction adaptor activity | The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way. |
| DNA polymerase binding | Interacting selectively and non-covalently with a DNA polymerase. |
| water channel activity | Transport systems of this type catalyze facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| glycerol channel activity | Catalysis of facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| transmembrane receptor protein tyrosine phosphatase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| STAT family protein binding | |
| filamin binding | Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. |
| protein kinase inhibitor activity | Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein. |
| protein tyrosine kinase inhibitor activity | Stops, prevents or reduces the activity of a protein tyrosine kinase. |
| cytochrome-c oxidase activity | Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. |
| glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. |
| mitochondrial large ribosomal subunit binding | |
| transmembrane ascorbate ferrireductase activity | |
| transcription coactivator binding | Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. |
| PDZ domain binding | Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins. |
| protein serine/threonine kinase inhibitor activity | Stops, prevents or reduces the activity of a protein serine/threonine kinase. |
| RNA polymerase II CTD heptapeptide repeat phosphatase activity | Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate. |
| HECT domain binding | |
| histone demethylase activity | Catalysis of the removal of a methyl group from a histone. |
| CXCR3 chemokine receptor binding | Interacting selectively and non-covalently with a the CXCR3 chemokine receptor. |
| neuropeptide receptor activity | Combining with a neuropeptide to initiate a change in cell activity. |
| G protein-coupled peptide receptor activity | Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| neuropeptide binding | Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). |
| phosphodiesterase I activity | Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides. |
| nucleoside triphosphate diphosphatase activity | Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide. |
| methylated histone binding | Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. |
| kinesin binding | Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. |
| endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. |
| metalloendopeptidase activity involved in amyloid precursor protein catabolic process | |
| ABC-type vitamin B12 transporter activity | |
| glutathione transferase activity | Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. |
| glutathione binding | Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine. |
| prostaglandin-E synthase activity | Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2). |
| histone H3K4 methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein. |
| GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. |
| tRNA methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. |
| tRNA (cytosine-5-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine. |
| cysteine-type endopeptidase activator activity involved in apoptotic process | Increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process. |
| caspase binding | Interacting selectively and non-covalently with a caspase family protein. |
| inositol monophosphate 1-phosphatase activity | Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. |
| MAP kinase kinase activity | Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. |
| JUN kinase kinase activity | Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase. |
| long-chain acyl-CoA hydrolase activity | Catalysis of the reaction: H2O + a long-chain acyl-CoA = a long-chain carboxylate + CoA. A long chain is a chain of greater than 12 carbons in length. |
| acetyl-CoA hydrolase activity | Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+). |
| CoA hydrolase activity | Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. |
| acyl-CoA hydrolase activity | Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. |
| medium-chain acyl-CoA hydrolase activity | Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. A medium chain is a chain of between eight and twelve carbons in length. |
| CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity | Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+). |
| acetyltransferase activator activity | Increases the activity of an aceyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule. |
| beta-tubulin binding | Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin. |
| methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. |
| methyl-CpG binding | Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide. |
| histone arginine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine. |
| protein-arginine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine. |
| protein-arginine omega-N symmetric methyltransferase activity | Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues. |
| histone H4R3 methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4. |
| gamma-aminobutyric acid transmembrane transporter activity | Catalysis of the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA). |
| beta-2 adrenergic receptor binding | Interacting selectively and non-covalently with a beta-2 adrenergic receptor. |
| type 2 metabotropic glutamate receptor binding | |
| type 3 metabotropic glutamate receptor binding | Interacting selectively and non-covalently with a type 3 metabotropic glutamate receptor. |
| growth factor receptor binding | Interacting selectively and non-covalently with a growth factor receptor. |
| telomerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. |
| telomerase RNA reverse transcriptase activity | Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template. |
| RNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. |
| RNA-dependent RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template. |
| telomerase RNA binding | Interacting selectively and non-covalently with the telomerase RNA template or to RNA complementary to it. |
| template-free RNA nucleotidyltransferase | |
| androsterone dehydrogenase activity | Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. |
| 5alpha-androstane-3beta,17beta-diol dehydrogenase activity | |
| androstan-3-alpha,17-beta-diol dehydrogenase activity | |
| histone H3T11 kinase activity | Catalysis of the transfer of a phosphate group to the threonine-11 residue of the N-terminal tail of histone H3. |
| TRAIL receptor activity | |
| fucose-1-phosphate guanylyltransferase activity | Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP = diphosphate + GDP-L-fucose. |
| serine-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| tripeptidyl-peptidase activity | Catalysis of the release of an N-terminal tripeptide from a polypeptide. |
| sulfatide binding | |
| ubiquitin-like protein conjugating enzyme binding | |
| vascular endothelial growth factor receptor activity | Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| semaphorin receptor activity | Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| tumor necrosis factor receptor binding | Interacting selectively and non-covalently with the tumor necrosis factor receptor. |
| tumor necrosis factor receptor superfamily binding | Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily. |
| [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity | Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S. |
| trimethylamine receptor activity | Combining with the biogenic amine trimethylamine to initiate a change in cell activity. |
| Hsp70 protein binding | Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size. |
| mitogen-activated protein kinase kinase kinase binding | Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase. |
| ferrous iron binding | Interacting selectively and non-covalently with ferrous iron, Fe(II). |
| carboxylic acid binding | Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). |
| phytanoyl-CoA dioxygenase activity | Catalysis of the reaction: 2-oxoglutarate + O(2) + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO(2) + succinate. |
| 5-oxoprolinase (ATP-hydrolyzing) activity | Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate. |
| bioactive lipid receptor activity | Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes. |
| cysteine-type endopeptidase activator activity | |
| zinc ion transmembrane transporter activity | Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. |
| [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity | Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate. |
| leukotriene-C4 synthase activity | Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4). |
| myosin binding | Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. |
| L27 domain binding | Interacting selectively and non-covalently with a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner. |
| IkappaB kinase activity | Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein. |
| transferrin receptor binding | Interacting selectively and non-covalently with the transferrin receptor. |
| histone acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. |
| histone H4K12 acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12). |
| ISG15 transferase activity | Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. |
| ubiquitin binding | Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
| guanylate kinase activity | Catalysis of the reaction: ATP + GMP = ADP + GDP. |
| phospholipase D activity | Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. |
| transmembrane receptor protein tyrosine kinase activator activity | Increases the activity of a transmembrane receptor protein tyrosine kinase. |
| phytanate-CoA ligase activity | Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H(+) + phytanoyl-CoA. |
| pristanate-CoA ligase activity | Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA. |
| ornithine decarboxylase activator activity | Upregulation of the activity of the enzyme ornithine decarboxylase. |
| P-type calcium transporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). |
| 1-phosphatidylinositol-3-phosphate 5-kinase activity | Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+). |
| 1-phosphatidylinositol-4-phosphate 5-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+). |
| 1-phosphatidylinositol-5-kinase activity | |
| phosphatidylinositol-3,4-bisphosphate 5-kinase activity | |
| protein phosphatase inhibitor activity | Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins. |
| promoter-specific chromatin binding | |
| semaphorin receptor binding | Interacting selectively and non-covalently with semaphorin receptors. |
| ubiquitin-protein transferase activator activity | Increases the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein. |
| histone H3K27me2/H3K27me3 demethylase activity | Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein. |
| phosphatidylinositol-3-phosphate phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate. |
| phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. |
| phosphatidylinositol phosphate 4-phosphatase activity | Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate. |
| phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity | Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate. |
| phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. |
| vinculin binding | Interacting selectively and non-covalently with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane. |
| phosphoribosylformylglycinamidine synthase activity | Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate. |
| microtubule minus-end binding | Interacting selectively and non-covalently with the minus end of a microtubule. |
| syntaxin-1 binding | Interacting selectively and non-covalently with the SNAP receptor syntaxin-1. |
| ribonuclease P activity | Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. |
| type I transforming growth factor beta receptor binding | Interacting selectively and non-covalently with a type I transforming growth factor beta receptor. |
| I-SMAD binding | Interacting selectively and non-covalently with an inhibitory SMAD signaling protein. |
| 1-acylglycerol-3-phosphate O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. |
| sphingolipid delta-4 desaturase activity | Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid. |
| retinol isomerase activity | |
| protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| nuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids. |
| phospholipid scramblase activity | Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism. |
| lead ion binding | Interacting selectively and non-covalently with lead (Pb) ions. |
| CD4 receptor binding | Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages. |
| mercury ion binding | Interacting selectively and non-covalently with mercury (Hg) ions. |
| estrogen response element binding | Interacting selectively and non-covalently with the estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen. |
| lysine-acetylated histone binding | Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation. |
| signaling receptor complex adaptor activity | Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex. |
| ephrin receptor activity | Combining with an ephrin to initiate a change in cell activity. |
| glycerone-phosphate O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA. |
| kynurenine 3-monooxygenase activity | Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+). |
| NAD(P)H oxidase H2O2-forming activity | Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide. |
| flavin adenine dinucleotide binding | Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
| acetylcholine transmembrane transporter activity | Catalysis of the transfer of acetylcholine from one side of the membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. |
| monoamine transmembrane transporter activity | Catalysis of the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of the membrane to the other. |
| prostaglandin transmembrane transporter activity | Catalysis of the transfer of prostaglandins from one side of the membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. |
| L-amino acid transmembrane transporter activity | Catalysis of the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. |
| pyrimidine nucleoside transmembrane transporter activity | |
| choline transmembrane transporter activity | Catalysis of the transfer of choline from one side of the membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. |
| thiamine transmembrane transporter activity | Catalysis of the transfer of thiamine from one side of the membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. |
| putrescine transmembrane transporter activity | Catalysis of the transfer of putrescine from one side of the membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. |
| spermidine transmembrane transporter activity | |
| quaternary ammonium group transmembrane transporter activity | Catalysis of the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. |
| L-arginine transmembrane transporter activity | Catalysis of the stereospecific transfer of L-arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane. |
| CCR6 chemokine receptor binding | |
| MAP kinase activity | Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. |
| serine C-palmitoyltransferase activity | Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA. |
| titin binding | Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively. |
| BMP binding | Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family. |
| FATZ binding | Interacting selectively and non-covalently with a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components. |
| titin Z domain binding | Interacting selectively and non-covalently with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34. |
| damaged DNA binding | Interacting selectively and non-covalently with damaged DNA. |
| acetylglucosaminyltransferase activity | Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. |
| linoleate 13S-lipoxygenase activity | Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. |
| arachidonate 15-lipoxygenase activity | Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate. |
| mitogen-activated protein kinase binding | Interacting selectively and non-covalently with a mitogen-activated protein kinase. |
| CD27 receptor binding | Interacting selectively and non-covalently with a CD27, a receptor found on the surface of T cells and some B cells and NK cells. |
| phosphomannomutase activity | Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate. |
| single-stranded DNA binding | Interacting selectively and non-covalently with single-stranded DNA. |
| phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. |
| inositol-1,3,4-trisphosphate 4-phosphatase activity | |
| inositol-3,4-bisphosphate 4-phosphatase activity | |
| proton-transporting ATPase activity, rotational mechanism | Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. |
| DNA binding, bending | The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. |
| prosaposin receptor activity | |
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity | Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-3,4-bisphosphate + phosphate. |
| mRNA cap binding | |
| transcription corepressor binding | Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery. |
| histone deacetylase activity | Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. |
| histone deacetylase binding | Interacting selectively and non-covalently with the enzyme histone deacetylase. |
| NF-kappaB binding | Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. |
| protein decrotonylase activity | |
| histone decrotonylase activity | |
| protein de-2-hydroxyisobutyrylase activity | |
| L-leucine transaminase activity | Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid. |
| L-valine transaminase activity | Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid. |
| L-isoleucine transaminase activity | Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid. |
| ionotropic glutamate receptor activity | Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. |
| NMDA glutamate receptor activity | An ionotropic glutamate receptor activity that exhibits slow gating by glutamate, acts by opening a nonselective cation channel, and can be activated by L-aspartate. |
| glutamate-gated calcium ion channel activity | |
| chloride channel inhibitor activity | Stops, prevents, or reduces the activity of a chloride channel. |
| lactate:proton symporter activity | |
| pyruvate transmembrane transporter activity | Catalysis of the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other. |
| copper ion transmembrane transporter activity | Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. |
| silver ion transmembrane transporter activity | |
| ABC-type xenobiotic transporter activity | Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out). |
| glucuronoside transmembrane transporter activity | |
| ABC-type glutathione S-conjugate transporter activity | |
| ABC-type bile acid transporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O -> bile acid(out) + ADP + phosphate. |
| guanine nucleotide transmembrane transporter activity | |
| purine nucleotide transmembrane transporter activity | Catalysis of the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other. |
| 15-hydroxyprostaglandin dehydrogenase (NAD+) activity | Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+. |
| glutathione transmembrane transporter activity | |
| CCR10 chemokine receptor binding | Interacting selectively and non-covalently with a CCR10 chemokine receptor. |
| double-stranded RNA binding | Interacting selectively and non-covalently with double-stranded RNA. |
| procollagen-proline 4-dioxygenase activity | Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2. |
| alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R. |
| sialyltransferase activity | Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. |
| chemoattractant activity | Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. |
| glycogenin glucosyltransferase activity | Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. |
| 1-alkyl-2-acetylglycerophosphocholine esterase activity | Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate. |
| phospholipase activity | Catalysis of the hydrolysis of a glycerophospholipid. |
| phospholipase A2 activity | Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. |
| calcium-dependent phospholipase A2 activity | Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+. |
| protein-cysteine S-palmitoyltransferase activity | Catalysis of the transfer of a palmitoyl group to a sulfur atom on the cysteine of a protein molecule. |
| oxysterol binding | Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol. |
| chromatin DNA binding | Interacting selectively and non-covalently with DNA that is assembled into chromatin. |
| fibroblast growth factor receptor binding | Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR). |
| type 2 fibroblast growth factor receptor binding | Interacting selectively and non-covalently with the type 2 fibroblast growth factor receptor (FGFR2). |
| growth factor activity | The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. |
| kinase inhibitor activity | Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. |
| oxidized purine nucleobase lesion DNA N-glycosylase activity | Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. |
| oxidized purine DNA binding | Interacting selectively and non-covalently with oxidized purine residues in DNA. |
| 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity | Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. |
| calcidiol 1-monooxygenase activity | Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+). |
| secalciferol 1-monooxygenase activity | |
| 3-phosphoinositide-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a phosphatidylinositol-3-phosphate. |
| phospholipase activator activity | Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid. |
| phospholipase binding | Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid. |
| ABC-type peptide antigen transporter activity | Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate. |
| MHC class I protein binding | Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. |
| TAP1 binding | Interacting selectively and non-covalently with the TAP1 subunit of TAP (transporter associated with antigen processing) protein. |
| TAP2 binding | Interacting selectively and non-covalently with the TAP2 subunit of TAP (transporter associated with antigen processing) protein. |
| kinase binding | Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
| purinergic nucleotide receptor activity | Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| extracellularly ATP-gated monoatomic cation channel activity | Catalysis of the transmembrane transfer of a cation by a channel that opens when extracellular ATP has been bound by the channel complex or one of its constituent parts. |
| channel activity | Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules. |
| calcium-activated potassium channel activity | Catalysis of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. |
| mRNA (guanine-N7-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine. |
| histone reader activity | |
| methylcytosine dioxygenase activity | Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2. |
| S-adenosylmethionine-dependent methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. |
| protein kinase A catalytic subunit binding | Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A. |
| protein kinase A regulatory subunit binding | Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A. |
| nitrite reductase (NO-forming) activity | |
| retinoic acid binding | Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. |
| retinoic acid 4-hydroxylase activity | Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. |
| all-trans retinoic acid 18-hydroxylase activity | |
| leucine zipper domain binding | Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. |
| basic amino acid transmembrane transporter activity | Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7. |
| adenylylsulfate kinase activity | Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate. |
| sulfate adenylyltransferase (ATP) activity | Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate. |
| nucleotidyltransferase activity | Catalysis of the transfer of a nucleotidyl group to a reactant. |
| centromeric DNA binding | Interacting selectively and non-covalently with a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis. |
| proline dehydrogenase activity | Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor. |
| alpha,alpha-trehalase activity | Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose. |
| MAP kinase kinase kinase activity | Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. |
| galactosyltransferase activity | Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
| UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity | Catalysis of the reaction: UDP-D-galactose + a glucosylceramide = a lactosylceramide + uridine-5'-diphosphate. The glucosylceramide has sphinganine as the long chain base. |
| endopeptidase inhibitor activity | Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. |
| serine-type endopeptidase inhibitor activity | Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. |
| GPI-anchor transamidase activity | Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor. |
| GPI anchor binding | Interacting selectively and non-covalently with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes. |
| cAMP response element binding protein binding | Interacting selectively and non-covalently with the cAMP response element binding protein. |
| Roundabout binding | Interacting selectively and non-covalently with the Roundabout (ROBO) receptor, a transmembrane receptor. |
| nuclear androgen receptor binding | Interacting selectively and non-covalently with an androgen receptor. |
| RNA polymerase III general transcription initiation factor binding | Interacting selectively and non-covalently with an RNA polymerase III transcription factor, any protein required to initiate or regulate transcription by RNA polymerase III. |
| protein kinase C binding | Interacting selectively and non-covalently with protein kinase C. |
| actin monomer binding | Interacting selectively and non-covalently with monomeric actin, also known as G-actin. |
| inositol-1,3,4,5,6-pentakisphosphate kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown. |
| inositol hexakisphosphate kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown. |
| inositol heptakisphosphate kinase activity | |
| inositol hexakisphosphate 5-kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate. |
| diphosphoinositol-pentakisphosphate kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate. |
| pyrimidine nucleobase transmembrane transporter activity | Catalysis of the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other. |
| urea transmembrane transporter activity | Enables the directed movement of urea cross a membrane into, out of or within a cell, or between cells. Urea is the water soluble compound H2N-CO-NH2. |
| urea channel activity | Catalysis of facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| MAP kinase kinase kinase kinase activity | Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli. |
| linear polyubiquitin binding | Interacting selectively and non-covalently with a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next. |
| patched binding | Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins. |
| non-membrane spanning protein tyrosine kinase activity | Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate. |
| LIM domain binding | Interacting selectively and non-covalently with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions. |
| disulfide oxidoreductase activity | Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. |
| phosphatidylinositol phosphate 5-phosphatase activity | Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate. |
| phosphatidylinositol-4-phosphate phosphatase activity | Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate. |
| inositol-1,4,5-trisphosphate 5-phosphatase activity | Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate. |
| fibroblast growth factor binding | Interacting selectively and non-covalently with a fibroblast growth factor. |
| RNA cap binding | Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. |
| cyclosporin A binding | Interacting selectively and non-covalently with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids. |
| alpha-1,4-glucosidase activity | Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose. |
| histone methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue. |
| histone H3K9 methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein. |
| alditol:NADP+ 1-oxidoreductase activity | Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. |
| phenanthrene-9,10-epoxide hydrolase activity | Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene. |
| actinin binding | Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin. |
| low voltage-gated calcium channel activity | Catalysis of the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded. |
| voltage-gated calcium channel activity involved in AV node cell action potential | |
| voltage-gated calcium channel activity involved SA node cell action potential | Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| crossover junction DNA endonuclease activity | Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). |
| N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. |
| glucuronosyltransferase activity | Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. |
| chloride transmembrane transporter activity | Catalysis of the transfer of chloride ions from one side of a membrane to the other. |
| iodide transmembrane transporter activity | Catalysis of the transfer of iodide ions from one side of a membrane to the other. |
| chloride:bicarbonate antiporter activity | |
| phosphatidylcholine flippase activity | |
| phosphatidylserine flippase activity | |
| ankyrin binding | Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. |
| HNK-1 sulfotransferase activity | Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R). |
| type I activin receptor binding | Interacting selectively and non-covalently with a type I activin receptor. |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. |
| JUN kinase binding | Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family. |
| deoxyribonucleoside 5'-monophosphate N-glycosidase activity | Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base. |
| galanin receptor activity | Combining with galanin to initiate a change in cell activity. |
| orexin receptor activity | Combining with orexin to initiate a change in cell activity. |
| acetylcholine receptor binding | Interacting selectively and non-covalently with an acetylcholine receptor. |
| arsenite transmembrane transporter activity | Catalysis of the transfer of arsenite from one side of a membrane to the other. |
| nuclear receptor coactivator activity | The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself. |
| maleylacetoacetate isomerase activity | Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate. |
| rRNA (guanine) methyltransferase activity | |
| phosphatidic acid transfer activity | Enables the directed movement of phosphatidic acid into, out of or within a cell, or between cells. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3. |
| glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP. |
| KDEL sequence binding | Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum. |
| AMP-activated protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP. |
| lipoate synthase activity | Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl. |
| ion channel inhibitor activity | Stops, prevents, or reduces the activity of an ion channel. |
| phosphatase inhibitor activity | Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. |
| potassium channel inhibitor activity | Stops, prevents, or reduces the activity of a potassium channel. |
| protein phosphatase regulator activity | Modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
| protein phosphatase 2A binding | Interacting selectively and non-covalently with the enzyme protein phosphatase 2A. |
| acyl carnitine transmembrane transporter activity | Enables the directed movement of acyl carnitine across a membrane. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane. |
| asparagine-tRNA ligase activity | Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+). |
| adenine nucleotide transmembrane transporter activity | Catalysis of the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of the membrane to the other. |
| ATP transmembrane transporter activity | Catalysis of the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other. |
| ADP transmembrane transporter activity | Catalysis of the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other. |
| coenzyme A transmembrane transporter activity | Enables the directed movement of coenzyme A across a membrane into, out of or within a cell, or between cells. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. |
| FAD transmembrane transporter activity | Enables the directed movement of flavin-adenine dinucleotide (FAD) across a membrane into, out of or within a cell, or between cells. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form. |
| FMN transmembrane transporter activity | Enables the directed movement of flavine mononucleotide (FMN) into, out of or within a cell, or between cells. |
| NAD transmembrane transporter activity | Enables the directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells; transport may be of either the oxidized form, NAD, or the reduced form, NADH. |
| AMP transmembrane transporter activity | Catalysis of the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other. |
| mRNA 3'-UTR AU-rich region binding | Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule. |
| U3 snoRNA binding | Interacting selectively and non-covalently with U3 small nucleolar RNA. |
| hyalurononglucosaminidase activity | Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. |
| hyaluronoglucuronidase activity | Catalysis of the random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate. |
| UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity | Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP. |
| glucose-6-phosphate transmembrane transporter activity | Catalysis of the transfer of glucose-6-phosphate from one side of the membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6. |
| glucose 6-phosphate:inorganic phosphate antiporter activity | |
| purine nucleoside transmembrane transporter activity | Catalysis of the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other. |
| aminopeptidase activity | Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. |
| glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan. |
| kinase activator activity | Increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| platelet-derived growth factor receptor binding | Interacting selectively and non-covalently with the platelet-derived growth factor receptor. |
| vascular endothelial growth factor receptor binding | Interacting selectively and non-covalently with any vascular endothelial growth factor receptor. |
| keratan sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate. |
| CXCR5 chemokine receptor binding | Interacting selectively and non-covalently with a CXCR5 chemokine receptor. |
| DNA replication origin binding | Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. |
| ubiquitin-dependent protein binding | |
| retinal dehydrogenase activity | Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal. |
| aldo-keto reductase (NADP) activity | Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. |
| alcohol dehydrogenase (NADP+) activity | |
| indanol dehydrogenase activity | Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+. |
| NADP-retinol dehydrogenase activity | Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+. |
| heparan sulfate 6-O-sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate. |
| nuclear vitamin D receptor binding | Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes. |
| type 1 fibroblast growth factor receptor binding | Interacting selectively and non-covalently with the type 1 fibroblast growth factor receptor (FGFR1). |
| ubiquitin conjugating enzyme binding | Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins. |
| ubiquitin-specific protease binding | Interacting selectively and non-covalently with a ubiquitin-specific protease. |
| F-box domain binding | Interacting selectively and non-covalently with an F-box domain of a protein. |
| histone octamer slider activity | |
| single-stranded RNA binding | Interacting selectively and non-covalently with single-stranded RNA. |
| 3'-5' RNA helicase activity | Catalysis of the unwinding of an RNA helix in the direction 3' to 5'. |
| glycosylceramide flippase activity | |
| histone H3 acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3. |
| telomeric DNA binding | Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. |
| histone H3K4 demethylase activity | Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein. |
| histone H3K9 demethylase activity | Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein. |
| telomeric repeat-containing RNA binding | |
| FAD-dependent H3K4me/H3K4me3 demethylase activity | |
| calcium channel activity | Catalysis of facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| monoatomic cation channel activity | Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. |
| glycine binding | Interacting selectively and non-covalently with glycine, aminoethanoic acid. |
| ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | |
| C-5 sterol desaturase activity | Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+. |
| linoleoyl-CoA desaturase activity | |
| omega-6 fatty acid desaturase activity | |
| acyl-CoA delta5-desaturase activity | |
| wide pore channel activity | Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts. |
| netrin receptor binding | |
| mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). |
| arachidonate-CoA ligase activity | Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+). |
| palmitoyl-CoA ligase activity | |
| phosphatidylinositol-4-phosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. |
| beta-N-acetylglucosaminidase activity | Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides. |
| N-acetyllactosamine synthase activity | Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine. |
| UDP-galactosyltransferase activity | Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule. |
| ribosomal large subunit binding | Interacting selectively and non-covalently with any part of the larger ribosomal subunit. |
| alpha-aminoacyl-tRNA binding | |
| GDP-mannose 4,6-dehydratase activity | Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O. |
| NADP+ binding | |
| glycylpeptide N-tetradecanoyltransferase activity | Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide. |
| cyclin-dependent protein serine/threonine kinase activator activity | |
| 7SK snRNA binding | Interacting selectively and non-covalently with a 7SK small nuclear RNA (7SK snRNA). |
| morphogen activity | Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient. |
| vascular endothelial growth factor receptor 2 binding | Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2. |
| interleukin-1 receptor binding | Interacting selectively and non-covalently with the interleukin-1 receptor. |
| Toll-like receptor binding | Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response. |
| triacyl lipopeptide binding | Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of three acyl groups. |
| peptidoglycan binding | Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. |
| protein kinase activator activity | Increases the activity of a protein kinase, an enzyme which phosphorylates a protein. |
| pyruvate secondary active transmembrane transporter activity | Catalysis of the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. |
| lactate transmembrane transporter activity | Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. |
| symporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
| 3'-5' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. |
| interleukin-12 receptor binding | Interacting selectively and non-covalently with the interleukin-12 receptor. |
| histone H3Y41 kinase activity | The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone. |
| hepatocyte growth factor binding | Interacting selectively and non-covalently with a hepatocyte growth factor. |
| UDP-glucose 6-dehydrogenase activity | Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate. |
| ATP-activated inward rectifier potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. |
| sulfonylurea receptor activity | Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| calcium, potassium:sodium antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in). |
| protein C-terminal carboxyl O-methyltransferase activity | Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein. |
| protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. |
| lysophospholipase activity | Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. |
| calcium-independent phospholipase A2 activity | Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+. |
| intracellular cAMP-activated cation channel activity | Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts. |
| voltage-gated sodium channel activity | Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated monoatomic cation channel activity | Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| leptin receptor binding | Interacting selectively and non-covalently with the leptin receptor. |
| prostaglandin-D synthase activity | Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2). |
| dolichyl-phosphate beta-D-mannosyltransferase activity | Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate. |
| folic acid transmembrane transporter activity | Enables the directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. |
| polyubiquitin modification-dependent protein binding | Interacting selectively and non-covalently with a polymer of ubiqutin. |
| clathrin heavy chain binding | Interacting selectively and non-covalently with a clathrin heavy chain. |
| myosin VI binding | Interacting selectively and non-covalently with a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments. |
| 6-phosphofructo-2-kinase activity | Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+). |
| pseudouridine synthase activity | Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. |
| box H/ACA snoRNA binding | |
| ubiquitin-like protein ligase activity | |
| RNA polymerase II CTD heptapeptide repeat kinase activity | Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats. |
| RNA polymerase II C-terminal domain binding | |
| amylin receptor activity | |
| calcitonin gene-related peptide receptor activity | Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity. |
| calcitonin gene-related peptide binding | |
| adrenomedullin receptor activity | Combining with adrenomedullin to initiate a change in cell activity. |
| adrenomedullin binding | |
| sphingomyelin phosphodiesterase activity | Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+). |
| phosphoric diester hydrolase activity | Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. |
| RNA-DNA hybrid ribonuclease activity | Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. |
| L-cystine transmembrane transporter activity | Catalysis of the transfer of L-cystine from one side of a membrane to the other. |
| solute:proton symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in). |
| voltage-gated sodium channel activity involved in cardiac muscle cell action potential | Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| mRNA guanylyltransferase activity | Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. |
| polynucleotide 5'-phosphatase activity | Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. |
| RNA guanylyltransferase activity | Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule. |
| inorganic triphosphate phosphatase activity | Catalysis of the reaction: H(2)O + triphosphate = diphosphate + phosphate. |
| ABC-type iron-sulfur cluster transporter activity | |
| phosphotransferase activity, alcohol group as acceptor | Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). |
| phosphotransferase activity, for other substituted phosphate groups | Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). |
| primary amine oxidase activity | Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. |
| tau-protein kinase activity | Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. |
| Rho-dependent protein serine/threonine kinase activity | |
| microtubule plus-end binding | Interacting selectively and non-covalently with the plus end of a microtubule. |
| inositol 1,3,4,5 tetrakisphosphate binding | Interacting selectively and non-covalently with inositol 1,3,4,5 tetrakisphosphate. |
| histone H4K20 demethylase activity | Catalysis of the reaction: histone H4 N6-methyl-L-lysine (position 20) + 2-oxoglutarate + O2 = histone H4 L-lysine (position 20) + succinate + formaldehyde + CO2. This reaction is the removal of a methyl group from lysine at position 20 of the histone H4 protein. |
| histone H3K36 demethylase activity | Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 36) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 36 of the histone H3 protein. |
| P-type manganese transporter activity | |
| xylulokinase activity | Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H(+). |
| coreceptor activity involved in Wnt signaling pathway | In cooperation with a primary Wnt receptor, initiating a change in cell activity through the Wnt signaling pathway. |
| coreceptor activity involved in canonical Wnt signaling pathway | |
| gamma-glutamylcyclotransferase activity | Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid. |
| oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. |
| extracellularly glycine-gated chloride channel activity | Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts. |
| glycine-gated chloride ion channel activity | |
| phosphatase activity | Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. |
| alkaline phosphatase activity | Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. |
| dinucleotide phosphatase activity | Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides. |
| arachidonate 12(S)-lipoxygenase activity | Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate. |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. |
| linoleate 9S-lipoxygenase activity | Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate. |
| GDP phosphatase activity | Catalysis of the reaction: GDP + H2O = GMP + phosphate. |
| nucleoside diphosphate phosphatase activity | Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate. |
| CDP phosphatase activity | |
| UDP phosphatase activity | Catalysis of the reaction: UDP + H2O = UMP + phosphate. |
| IDP phosphatase activity | |
| ADP phosphatase activity | Catalysis of the reaction: ADP + H2O = AMP + phosphate. |
| prenylated protein tyrosine phosphatase activity | Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate. |
| rDNA binding | Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA. |
| double-stranded methylated DNA binding | Interacting selectively and non-covalently with double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks. |
| nucleosomal DNA binding | Interacting selectively and non-covalently with the DNA portion of a nucleosome. |
| poly-ADP-D-ribose modification-dependent protein binding | |
| GTPase binding | Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP. |
| L-valine transmembrane transporter activity | |
| amino acid transmembrane transporter activity | Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. |
| neutral L-amino acid transmembrane transporter activity | Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7. |
| L-isoleucine transmembrane transporter activity | |
| L-leucine transmembrane transporter activity | Catalysis of the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid. |
| citrate (Si)-synthase activity | Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group. |
| nuclear glucocorticoid receptor binding | Interacting selectively and non-covalently with a glucocorticoid receptor. |
| peroxisome proliferator activated receptor binding | Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma. |
| nuclear retinoid X receptor binding | Interacting selectively and non-covalently with a retinoid X receptor. |
| nuclear thyroid hormone receptor binding | Interacting selectively and non-covalently with a thyroid hormone receptor. |
| nucleoside diphosphate kinase activity | Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. |
| DNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. |
| single-stranded DNA helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix. |
| 5'-deoxyribose-5-phosphate lyase activity | Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site. |
| ADP binding | Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate. |
| ciliary neurotrophic factor receptor binding | Interacting selectively and non-covalently with the ciliary neurotrophic factor receptor. |
| supercoiled DNA binding | Interacting selectively and non-covalently with supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA. |
| coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway | |
| carbonate dehydratase activity | Catalysis of the reaction: H2CO3 = CO2 + H2O. |
| RS domain binding | Interacting selectively and non-covalently with an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing. |
| mannose binding | Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. |
| pre-miRNA binding | Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA. |
| collagen binding involved in cell-matrix adhesion | Any collagen binding that occurs as part of cell-matrix adhesion. |
| histone H3S10 kinase activity | Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3. |
| histone H3S28 kinase activity | |
| histone H2AS1 kinase activity | |
| peptidoglycan immune receptor activity | Combining with a peptidoglycan and transmitting the signal to initiate a change in cell activity. |
| glycine C-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+). |
| lipase activity | Catalysis of the hydrolysis of a lipid or phospholipid. |
| rRNA binding | Interacting selectively and non-covalently with ribosomal RNA. |
| ribosomal protein S6 kinase activity | Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP. |
| gap junction channel activity | A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. |
| 3-sulfino-L-alanine: proton, glutamate antiporter activity | |
| aspartate:glutamate, proton antiporter activity | |
| acidic amino acid transmembrane transporter activity | Catalysis of the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7. |
| phosphatidylinositol phosphate kinase activity | Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate. |
| galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide. |
| calcium-release channel activity | Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
| temperature-gated cation channel activity | Catalysis of the transmembrane transfer of a cation by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism). |
| protein phosphatase 1 binding | Interacting selectively and non-covalently with the enzyme protein phosphatase 1. |
| protein phosphatase activator activity | Increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
| ribonuclease P RNA binding | Interacting selectively and non-covalently with the RNA subunit of ribonuclease P. |
| carbonyl reductase (NADPH) activity | Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+. |
| NADPH dehydrogenase (quinone) activity | |
| NADPH binding | Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
| metalloexopeptidase activity | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| isocitrate dehydrogenase (NADP+) activity | Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+. |
| oxysterol 7-alpha-hydroxylase activity | Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O. |
| formyltetrahydrofolate dehydrogenase activity | Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO(2) + H(+) + NADPH. |
| G protein-coupled GABA receptor activity | Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| diacylglycerol O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. |
| sterol O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester. |
| cholesterol O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA. |
| cyclin-dependent protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). |
| diacylglycerol kinase activity | Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate. |
| gamma-butyrobetaine dioxygenase activity | Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O(2) = carnitine + CO(2) + succinate. |
| serine-type carboxypeptidase activity | Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| acetylcholine receptor activity | Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| peptidase activator activity | Increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. |
| tropomyosin binding | Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. |
| delta14-sterol reductase activity | Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol. |
| NADP binding | |
| 3',5'-cyclic-nucleotide phosphodiesterase activity | Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate. |
| DNA nuclease activity | Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. |
| disordered domain specific binding | |
| carnitine transmembrane transporter activity | Enables the directed movement of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. |
| (R)-carnitine transmembrane transporter activity | |
| bicarbonate transmembrane transporter activity | Catalysis of the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. |
| ribosome binding | Interacting selectively and non-covalently with any part of a ribosome. |
| signal recognition particle binding | Interacting selectively and non-covalently with the signal recognition particle. |
| 7S RNA binding | Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). |
| 5'-3' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. |
| mRNA 5'-diphosphatase activity | Catalysis of the removal of a 5' terminal pyrophosphate from the 5'-triphosphate end of an RNA, leaving a 5'-monophosphate end. |
| RNA NAD-cap (NAD-forming) hydrolase activity | |
| ADP-ribose diphosphatase activity | Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate. |
| mono-ADP-D-ribose binding | |
| ligand-gated calcium channel activity | |
| dimethylargininase activity | Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline. |
| 3'-5' DNA helicase activity | Catalysis of the unwinding of the DNA helix in the direction 3' to 5'. |
| bubble DNA binding | Interacting selectively and non-covalently with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA. |
| telomeric D-loop binding | |
| DNA/DNA annealing activity | |
| RNA polymerase II complex binding | Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. |
| galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity | Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein. |
| ammonium transmembrane transporter activity | Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. |
| methylammonium channel activity | |
| 3-chloroallyl aldehyde dehydrogenase activity | Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid. |
| retinal binding | Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. |
| protein kinase C activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. |
| glutamine-fructose-6-phosphate transaminase (isomerizing) activity | Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. |
| laminin-1 binding | Interacting selectively and non-covalently with laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1. |
| mitochondrion targeting sequence binding | |
| UFM1 ligase activity | |
| mechanosensitive monoatomic ion channel activity | Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress. |
| cytoskeleton-nuclear membrane anchor activity | |
| receptor antagonist activity | Interacts with receptors to reduce the action of another ligand, the agonist. |
| latrotoxin receptor activity | Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| heparosan-N-sulfate-glucuronate 5-epimerase activity | Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate. |
| glutaminase activity | Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3. |
| ubiquitin-ubiquitin ligase activity | Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. |
| sodium-independent organic anion transmembrane transporter activity | Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. |
| histone H2AK119 ubiquitin ligase activity | |
| cyclin-dependent protein serine/threonine kinase inhibitor activity | Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. |
| snRNA binding | Interacting selectively and non-covalently with a small nuclear RNA (snRNA). |
| uridine phosphorylase activity | Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. |
| deoxyuridine phosphorylase activity | |
| amine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. |
| outward rectifier potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force. |
| RNA polymerase II C-terminal domain phosphoserine binding | |
| sphingosine-1-phosphate receptor activity | Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein. |
| benzodiazepine receptor binding | Interacting selectively and non-covalently with the peripheral benzodiazepine receptor (PBR). |
| voltage-gated monoatomic ion channel activity | Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| netrin receptor activity | Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| netrin receptor activity involved in chemorepulsion | |
| ornithine decarboxylase inhibitor activity | The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase. |
| calcium:proton antiporter activity | |
| glycogen binding | Interacting selectively and non-covalently with glycogen. |
| O-palmitoyltransferase activity | Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule. |
| phosphatidylcholine-retinol O-acyltransferase activity | Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine. |
| satellite DNA binding | Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA. |
| DNA endonuclease activity | Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. |
| pyrimidine-specific mismatch base pair DNA N-glycosylase activity | Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site. |
| DNA N-glycosylase activity | Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. |
| protein tyrosine/serine/threonine phosphatase activity | Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| histone H4K16 acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4. |
| histone H4 acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4. |
| histone H3K14 acetyltransferase activity | |
| histone H3K23 acetyltransferase activity | |
| histone H4K5 acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5). |
| histone H4K8 acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8). |
| histone H3K4 acetyltransferase activity | |
| interleukin-18 receptor activity | Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| cyclic nucleotide binding | Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. |
| delayed rectifier potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and activation is slow. |
| phosphatidylinositol bisphosphate binding | Interacting selectively and non-covalently with phosphatidylinositol bisphosphate. |
| arginyltransferase activity | Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein. |
| NAD+ ADP-ribosyltransferase activity | Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. |
| FFAT motif binding | Interacting selectively and non-covalently with the FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family. |
| pre-mRNA binding | Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. |
| 6-phosphogluconolactonase activity | Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+). |
| canalicular bile acid transmembrane transporter activity | The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. |
| NACHT domain binding | Interacting selectively and non-covalently with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs. |
| phenylalanine-tRNA ligase activity | Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). |
| histone acetyltransferase binding | Interacting selectively and non-covalently with the enzyme histone acetyltransferase. |
| second spliceosomal transesterification activity | Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. |
| pre-mRNA 3'-splice site binding | Interacting selectively and non-covalently with the pre-mRNA 3' splice site sequence. |
| telethonin binding | Interacting selectively and non-covalently with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase. |
| receptor serine/threonine kinase binding | Interacting selectively and non-covalently with a receptor that possesses protein serine/threonine kinase activity. |
| phosphoacetylglucosamine mutase activity | Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate. |
| beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R. |
| thiosulfate sulfurtransferase activity | Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate. |
| sulfurtransferase activity | Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). |
| 1-phosphatidylinositol binding | Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
| mannose-ethanolamine phosphotransferase activity | Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor. |
| gap junction channel activity involved in cell communication by electrical coupling | |
| hexosyltransferase activity | Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). |
| manganese ion binding | Interacting selectively and non-covalently with manganese (Mn) ions. |
| xylosyltransferase activity | Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
| sphinganine-1-phosphate aldolase activity | Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde. |
| apolipoprotein A-I binding | Interacting selectively and non-covalently with apolipoprotein A-I. |
| sphingolipid floppase activity | |
| phosphatidylcholine floppase activity | |
| phosphatidylserine floppase activity | |
| cholesterol transfer activity | |
| glucose-6-phosphate dehydrogenase activity | Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. |
| pantetheine hydrolase activity | Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine. |
| carbohydrate:proton symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). |
| dehydroascorbic acid transmembrane transporter activity | Enables the directed movement of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| D-glucose transmembrane transporter activity | Catalysis of the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of the membrane to the other. |
| NAD+ kinase activity | Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+). |
| tyrosyl-RNA phosphodiesterase activity | Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis. |
| 5'-tyrosyl-DNA phosphodiesterase activity | Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA. |
| protein-L-histidine N-tele-methyltransferase activity | |
| sulfur dioxygenase activity | Catalysis of the reaction: sulfur + O2 + H2O = sulfite. |
| RNA polymerase I activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| adenylate cyclase binding | Interacting selectively and non-covalently with the enzyme adenylate cyclase. |
| deubiquitinase activity | |
| mitogen-activated protein kinase p38 binding | Interacting selectively and non-covalently with mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation. |
| phosphatidate cytidylyltransferase activity | Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol. |
| farnesyltranstransferase activity | Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. |
| U6 snRNA binding | Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA). |
| C-C chemokine receptor activity | Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. |
| [heparan sulfate]-glucosamine N-sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine. |
| heparan sulfate N-deacetylase activity | |
| creatine kinase activity | Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). |
| malonyl-CoA decarboxylase activity | Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2. |
| NADPH:quinone reductase activity | Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone. |
| UDP-sugar diphosphatase activity | Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate. |
| 3'(2'),5'-bisphosphate nucleotidase activity | Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate. |
| protein-disulfide reductase (glutathione) activity | Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol. |
| protein-glutamine gamma-glutamyltransferase activity | Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. |
| glutamate formimidoyltransferase activity | Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate. |
| formimidoyltetrahydrofolate cyclodeaminase activity | Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH(4)(+). |
| MHC class I receptor activity | Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules. |
| MHC class Ib receptor activity | |
| activating MHC class I receptor activity | Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte. |
| metalloendopeptidase inhibitor activity | Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. |
| diphosphoinositol-polyphosphate diphosphatase activity | Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate. |
| inositol diphosphate tetrakisphosphate diphosphatase activity | Catalysis of the reaction: inositol diphosphate tetrakisphosphate + H2O = inositol 1,3,4,5,6-pentakisphosphate + phosphate. |
| inositol diphosphate pentakisphosphate diphosphatase activity | Catalysis of the reaction: inositol diphosphate pentakisphosphate + H2O = inositol hexakisphosphate + phosphate. |
| cholesterol 25-hydroxylase activity | Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O. |
| cysteine-type endopeptidase inhibitor activity | Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| interleukin-18 binding | Interacting selectively and non-covalently with interleukin-18. |
| protein kinase B binding | Interacting selectively and non-covalently with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism. |
| general transcription initiation factor binding | |
| molybdopterin synthase activity | Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis. |
| aspartic-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. |
| histone H4K20 methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein. |
| histone H3K36 methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein. |
| alcohol dehydrogenase activity, zinc-dependent | Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc. |
| alcohol dehydrogenase (NAD+) activity | Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. |
| L-lactate dehydrogenase activity | Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. |
| aldehyde dehydrogenase (NAD+) activity | Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. |
| aminobutyraldehyde dehydrogenase activity | Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+. |
| NAD binding | |
| 3-deoxyglucosone dehydrogenase activity | |
| glutamate dehydrogenase (NAD+) activity | Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+. |
| glutamate dehydrogenase [NAD(P)+] activity | |
| NAD+ binding | |
| leucine binding | Interacting selectively and non-covalently with 2-amino-4-methylpentanoic acid. |
| dihydrofolate reductase activity | Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. |
| sequence-specific mRNA binding | |
| cytochrome-b5 reductase activity, acting on NAD(P)H | |
| phenylalanine 4-monooxygenase activity | Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin. |
| protein phosphatase 2B binding | Interacting selectively and non-covalently with the enzyme protein phosphatase 2B. |
| ferroxidase activity | Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O. |
| ornithine carbamoyltransferase activity | Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. |
| purine nucleobase binding | Interacting selectively and non-covalently with a purine nucleobase, an organic nitrogenous base with a purine skeleton. |
| purine-nucleoside phosphorylase activity | Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. |
| hypoxanthine phosphoribosyltransferase activity | Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. |
| guanine phosphoribosyltransferase activity | Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate. |
| L-aspartate:2-oxoglutarate aminotransferase activity | Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. |
| nicotinate-nucleotide adenylyltransferase activity | Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+. |
| neuropilin binding | Interacting selectively and non-covalently with a member of the neuropilin family. |
| ephrin receptor binding | Interacting selectively and non-covalently with an ephrin receptor. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
| epidermal growth factor receptor activity | Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| protein tyrosine kinase activator activity | Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein. |
| phosphoglycerate kinase activity | Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+). |
| protein-disulfide reductase (NAD(P)) activity | Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+. |
| adenylate kinase activity | Catalysis of the reaction: ATP + AMP = 2 ADP. |
| adenosine deaminase activity | Catalysis of the reaction: adenosine + H2O = inosine + NH3. |
| deaminase activity | Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3). |
| 2'-deoxyadenosine deaminase activity | |
| arylesterase activity | Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. |
| hydro-lyase activity | Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. |
| argininosuccinate synthase activity | Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate. |
| amino acid binding | Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. |
| 2'-5'-oligoadenylate synthetase activity | Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA. |
| type 1 angiotensin receptor binding | Interacting selectively and non-covalently with a type 1 angiotensin receptor. |
| type 2 angiotensin receptor binding | Interacting selectively and non-covalently with a type 2 angiotensin receptor. |
| interleukin-8 binding | Interacting selectively and non-covalently with interleukin-8. |
| tumor necrosis factor binding | Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages. |
| C5L2 anaphylatoxin chemotactic receptor binding | Interacting selectively and non-covalently with a C5L2 anaphylatoxin chemotactic receptor. |
| RNA polymerase II core promoter sequence-specific DNA binding | Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery. |
| superoxide-generating NADPH oxidase activator activity | Increases the activity of the enzyme superoxide-generating NADPH oxidase. |
| platelet-derived growth factor binding | Interacting selectively and non-covalently with platelet-derived growth factor. |
| low-density lipoprotein particle binding | Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. |
| type II transforming growth factor beta receptor binding | Interacting selectively and non-covalently with a type II transforming growth factor beta receptor. |
| type III transforming growth factor beta receptor binding | Interacting selectively and non-covalently with a type III transforming growth factor beta receptor. |
| nerve growth factor receptor binding | Interacting selectively and non-covalently with the nerve growth factor receptor. |
| hormone receptor binding | Interacting selectively and non-covalently with a receptor for hormones. |
| neuropeptide receptor binding | Interacting selectively and non-covalently with a neuropeptide receptor. |
| V1A vasopressin receptor binding | Interacting selectively and non-covalently with a V1A vasopressin receptor. |
| type 3 melanocortin receptor binding | Interacting selectively and non-covalently with a type 3 melanocortin receptor. |
| type 4 melanocortin receptor binding | Interacting selectively and non-covalently with a type 4 melanocortin receptor. |
| type 1 melanocortin receptor binding | Interacting selectively and non-covalently with a type 1 melanocortin receptor. |
| follicle-stimulating hormone activity | The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis. |
| prolactin receptor binding | Interacting selectively and non-covalently with the prolactin receptor. |
| calcitonin receptor binding | Interacting selectively and non-covalently with a calcitonin receptor. |
| type 1 parathyroid hormone receptor binding | Interacting selectively and non-covalently with a type 1 parathyroid hormone receptor. |
| peptide hormone receptor binding | Interacting selectively and non-covalently with a receptor for peptide hormones. |
| growth hormone-releasing hormone activity | The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland. |
| growth hormone-releasing hormone receptor binding | Interacting selectively and non-covalently with a growth hormone-releasing hormone receptor. |
| death receptor agonist activity | |
| cytokine receptor binding | Interacting selectively and non-covalently with a cytokine receptor. |
| chloramphenicol O-acetyltransferase activity | |
| erythropoietin receptor binding | Interacting selectively and non-covalently with the erythropoietin receptor. |
| interleukin-2 receptor activity | Combining with interleukin-2 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| IgA binding | Interacting selectively and non-covalently with an immunoglobulin of an IgA isotype. |
| MHC class II protein complex binding | Interacting selectively and non-covalently with the class II major histocompatibility complex. |
| interleukin-16 binding | |
| interleukin-16 receptor activity | |
| MHC class II protein binding | Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. |
| protein tyrosine kinase binding | |
| MHC class I protein complex binding | Interacting selectively and non-covalently with the class I major histocompatibility complex. |
| polymeric immunoglobulin receptor activity | Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| MHC class II receptor activity | Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| keratin filament binding | Interacting selectively and non-covalently with a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. |
| apolipoprotein receptor binding | Interacting selectively and non-covalently with an apolipoprotein receptor. |
| apolipoprotein A-I receptor binding | Interacting selectively and non-covalently with an apolipoprotein A-I receptor. |
| chemorepellent activity | Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. |
| phosphatidylcholine-sterol O-acyltransferase activator activity | Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines. |
| high-density lipoprotein particle receptor binding | Interacting selectively and non-covalently with a high-density lipoprotein receptor. |
| metal chelating activity | The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring. |
| very-low-density lipoprotein particle receptor binding | Interacting selectively and non-covalently with a very-low-density lipoprotein receptor. |
| lipase inhibitor activity | Stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. |
| phospholipase inhibitor activity | Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. |
| lipoprotein lipase activator activity | Increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein. |
| acetylcholine-gated monoatomic cation-selective channel activity | Catalysis of the transmembrane transfer of a cation by a channel that opens when acetylcholine has been bound by the channel complex or one of its constituent parts. |
| transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | |
| solute:inorganic anion antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out). |
| monoatomic anion transmembrane transporter activity | Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other. |
| retinol binding | Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. |
| calcium channel inhibitor activity | Stops, prevents, or reduces the activity of a calcium channel. |
| enterobactin binding | |
| calcidiol binding | Interacting selectively and non-covalently with calcidiol. |
| glucose transmembrane transporter activity | Catalysis of the transfer of the hexose monosaccharide glucose from one side of the membrane to the other. |
| cAMP-dependent protein kinase regulator activity | Modulation of the activity of the enzyme cAMP-dependent protein kinase. |
| structural constituent of tooth enamel | The action of a molecule that contributes to the structural integrity of tooth enamel. |
| TFIIB-class transcription factor binding | Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor. |
| TBP-class protein binding | Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). |
| nuclear estrogen receptor activity | Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function. |
| hydroxymethylglutaryl-CoA reductase (NADPH) activity | Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH. |
| coenzyme A binding | |
| DNA nucleotidylexotransferase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). |
| bile acid binding | Interacting selectively and non-covalently with bile acids, any of a group of steroid carboxylic acids occurring in bile. |
| glucosylceramidase activity | Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. |
| scavenger receptor binding | Interacting selectively and non-covalently with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles. |
| glucosyltransferase activity | Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
| steryl-beta-glucosidase activity | |
| alpha-L-fucosidase activity | Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose. |
| fructose-bisphosphate aldolase activity | Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate. |
| fructose binding | Interacting selectively and non-covalently with the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose. |
| phospholipase A2 inhibitor activity | Stops, prevents or reduces the activity of the enzyme phospholipase A2. |
| lipase binding | Interacting selectively and non-covalently with any lipase. |
| type 8 metabotropic glutamate receptor binding | |
| type 5 metabotropic glutamate receptor binding | Interacting selectively and non-covalently with a type 5 metabotropic glutamate receptor. |
| phosphatidylcholine-sterol O-acyltransferase activity | Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine. |
| sterol esterase activity | Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid. |
| platelet-activating factor acetyltransferase activity | Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid. |
| ornithine(lysine) transaminase activity | |
| angiotensin receptor activity | Combining with angiotensin to initiate a change in cell activity. |
| angiotensin type II receptor activity | An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms. |
| cytokine receptor activity | Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| macrophage migration inhibitory factor binding | Interacting selectively and non-covalently with the cytokine, macrophage migration inhibitory factor. |
| MHC class II protein binding, via antigen binding groove | Interacting selectively and non-covalently with the antigen binding groove of major histocompatibility complex class II molecules. |
| RAGE receptor binding | Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products. |
| argininosuccinate lyase activity | Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. |
| CD8 receptor binding | Interacting selectively and non-covalently with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes. |
| cadmium ion binding | Interacting selectively and non-covalently with cadmium (Cd) ions. |
| RNA polymerase I core binding | Interacting selectively and non-covalently with RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits. |
| ErbB-3 class receptor binding | Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-3/HER3. |
| nerve growth factor receptor activity | Combining with nerve growth factor (NGF), to prevent apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity. |
| nerve growth factor binding | Interacting selectively and non-covalently with nerve growth factor (NGF). |
| calcium-dependent cysteine-type endopeptidase activity | Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. |
| alpha-amylase activity | Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units. |
| chloride ion binding | Interacting selectively and non-covalently with chloride ions (Cl-). |
| protein kinase C inhibitor activity | Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein. |
| arachidonic acid monooxygenase activity | Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. |
| vitamin D 24-hydroxylase activity | Catalysis of the hydroxylation of C-24 of any form of vitamin D. |
| estrogen 16-alpha-hydroxylase activity | |
| estrogen 2-hydroxylase activity | |
| long-chain fatty acid omega-hydroxylase activity | |
| long-chain fatty acid omega-1 hydroxylase activity | |
| thymidylate synthase activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. |
| superoxide-generating NAD(P)H oxidase activity | Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-. |
| dolichyl-diphosphooligosaccharide-protein glycotransferase activity | Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. |
| P-type sodium:potassium-exchanging transporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). |
| fructose-1-phosphate aldolase activity | Catalysis of the reaction: D-fructose-1-phosphate = dihydroxyacetone phosphate + D-glyceraldehyde. |
| PTB domain binding | Interacting selectively and non-covalently with a phosphotyrosine-binding (PTB) domain of a protein. |
| aldehyde dehydrogenase [NAD(P)+] activity | |
| phenylacetaldehyde dehydrogenase activity | |
| nitroglycerin reductase activity | |
| steroid 17-alpha-monooxygenase activity | Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. |
| 17-alpha-hydroxyprogesterone aldolase activity | Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione. |
| C-X3-C chemokine binding | |
| insulin-like growth factor I binding | Interacting selectively and non-covalently with insulin-like growth factor I. |
| neuregulin binding | |
| complement component C3b binding | Interacting selectively and non-covalently with the C3b product of the complement cascade. |
| ICAM-3 receptor activity | Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues. |
| cholesterol monooxygenase (side-chain-cleaving) activity | Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O. |
| Toll-like receptor 4 binding | Interacting selectively and non-covalently with a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response. |
| interleukin-4 receptor binding | Interacting selectively and non-covalently with the interleukin-4 receptor. |
| ATP:ADP antiporter activity | Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out). |
| adenine transmembrane transporter activity | Catalysis of the transfer of adenine, 6-aminopurine, from one side of a membrane to the other. |
| acrosin binding | Interacting selectively and non-covalently with acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities. |
| propionyl-CoA carboxylase activity | Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. |
| caffeine oxidase activity | Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O. |
| 4-nitrophenol 2-monooxygenase activity | |
| pyrophosphatase activity | Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments. |
| pyridoxal phosphatase activity | Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate. |
| phosphoamidase activity | |
| phosphoethanolamine phosphatase activity | Catalysis of the reaction: O-phosphoethanolamine + H2O = ethanolamine + phosphate. |
| interleukin-6 receptor binding | Interacting selectively and non-covalently with the interleukin-6 receptor. |
| endothelin A receptor binding | Interacting selectively and non-covalently with an endothelin A receptor. |
| endothelin B receptor binding | Interacting selectively and non-covalently with an endothelin B receptor. |
| cAMP response element binding | Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP. |
| long-chain fatty acid binding | Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
| oleic acid binding | Interacting selectively and non-covalently with oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid. |
| kringle domain binding | Interacting selectively and non-covalently with a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors. |
| poly(U) RNA binding | Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule. |
| nuclear receptor corepressor activity | |
| histone H3T6 kinase activity | Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3. |
| uroporphyrinogen decarboxylase activity | Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. |
| insulin receptor activity | Combining with insulin and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| insulin-like growth factor II binding | Interacting selectively and non-covalently with insulin-like growth factor II. |
| acetylcholinesterase activity | Catalysis of the reaction: acetylcholine + H2O = choline + acetate. |
| cholinesterase activity | Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion. |
| alpha-galactosidase activity | Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase. |
| galactosylgalactosylglucosylceramidase activity | |
| phosphatidylinositol 3-kinase catalytic subunit binding | Interacting selectively and non-covalently with the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. |
| myosin II binding | Interacting selectively and non-covalently with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin. |
| histone kinase activity | Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. |
| cyclin-dependent protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). |
| RNA 7-methylguanosine cap binding | Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. |
| eukaryotic initiation factor 4G binding | Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation. |
| phosphopyruvate hydratase activity | Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. |
| low-affinity IgE receptor activity | |
| IgE binding | Interacting selectively and non-covalently with an immunoglobulin of the IgE isotype. |
| glucose binding | Interacting selectively and non-covalently with the D- or L-enantiomer of glucose. |
| glycogen phosphorylase activity | Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate. |
| AMP binding | Interacting selectively and non-covalently with AMP, adenosine monophosphate. |
| glucose-6-phosphate isomerase activity | Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. |
| DNA-(apurinic or apyrimidinic site) endonuclease activity | Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. |
| transforming growth factor beta binding | Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. |
| lipoprotein lipase activity | Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein. |
| triglyceride lipase activity | Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. |
| phospholipase A1 activity | Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate. |
| lipoprotein particle binding | Interacting selectively and non-covalently with a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. |
| beta-N-acetylhexosaminidase activity | Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. |
| epoxide hydrolase activity | Catalysis of the reaction: an epoxide + H2O = a glycol. |
| cis-stilbene-oxide hydrolase activity | Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol. |
| tyrosine 3-monooxygenase activity | Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. |
| thiol oxidase activity | Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O. |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. |
| macrophage colony-stimulating factor receptor activity | Combining with macrophage colony-stimulating factor (M-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
| aspartic-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. |
| thrombin-activated receptor activity | Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. |
| beta2-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors. |
| norepinephrine binding | Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. |
| ganglioside GM1 binding | |
| ganglioside GM2 binding | |
| ganglioside GM3 binding | |
| ganglioside GT1b binding | |
| ganglioside GP1c binding | |
| bisphosphoglycerate mutase activity | Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate. |
| adenine phosphoribosyltransferase activity | Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. |
| glutamate-tRNA ligase activity | Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). |
| proline-tRNA ligase activity | Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). |
| UDP-glucose:hexose-1-phosphate uridylyltransferase activity | Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose. |
| IgG binding | Interacting selectively and non-covalently with an immunoglobulin of an IgG isotype. |
| ubiquinol-cytochrome-c reductase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. |
| phosphorylation-dependent protein binding | |
| fumarate hydratase activity | Catalysis of the reaction: (S)-malate = fumarate + H(2)O. |
| single-stranded DNA endodeoxyribonuclease activity | Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks. |
| 3' overhang single-stranded DNA endodeoxyribonuclease activity | |
| collagen V binding | Interacting selectively and non-covalently with a type V collagen trimer. |
| insulin-like growth factor receptor activity | Combining with insulin-like growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| insulin-like growth factor binding | Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it. |
| 11-cis retinal binding | Interacting selectively and non-covalently with 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A. |
| G protein-coupled photoreceptor activity | Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| ligand-gated monoatomic ion channel activity | Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
| neurotrophin binding | Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth. |
| G protein-coupled acetylcholine receptor activity | Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| carboxylic acid transmembrane transporter activity | Catalysis of the transfer of carboxylic acids from one side of the membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). |
| phosphatidylethanolamine flippase activity | |
| ceramide floppase activity | |
| calcium:sodium antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in). |
| aromatic amino acid transmembrane transporter activity | Catalysis of the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring. |
| L-alanine transmembrane transporter activity | Catalysis of the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid. |
| beta-glucuronidase activity | Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate. |
| 6-phosphofructokinase activity | Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate. |
| asparagine synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. |
| steroid delta-isomerase activity | Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid. |
| all-trans retinal binding | Interacting selectively and non-covalently with all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A. |
| oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. |
| benzaldehyde dehydrogenase [NAD(P)+] activity | Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+. |
| hydroxymethylbilane synthase activity | Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+). |
| exopeptidase activity | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. |
| type II activin receptor binding | Interacting selectively and non-covalently with a type II activin receptor. |
| pyruvate dehydrogenase (acetyl-transferring) activity | Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. |
| opsonin receptor activity | Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| beta-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. |
| alpha-2A adrenergic receptor binding | Interacting selectively and non-covalently with an alpha-2A adrenergic receptor. |
| myosin II heavy chain binding | Interacting selectively and non-covalently with a heavy chain of a myosin II complex. |
| U1 snRNA binding | Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA). |
| low-affinity IgG receptor activity | |
| steroid hydroxylase activity | Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. |
| vitamin D3 25-hydroxylase activity | Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O. |
| testosterone 6-beta-hydroxylase activity | Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O. |
| 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity | |
| steroid 21-monooxygenase activity | Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O. |
| 17-hydroxyprogesterone 21-hydroxylase activity | |
| progesterone 21-hydroxylase activity | |
| interleukin-3 receptor binding | Interacting selectively and non-covalently with the interleukin-3 receptor. |
| sulfuric ester hydrolase activity | Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2. |
| ciliary neurotrophic factor receptor activity | Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| interleukin-6 receptor activity | Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| interleukin-6 binding | Interacting selectively and non-covalently with interleukin-6. |
| ciliary neurotrophic factor binding | Interacting selectively and non-covalently with the cytokine ciliary neurotrophic factor. |
| G protein-coupled serotonin receptor activity | Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. |
| receptor-receptor interaction | |
| acetylesterase activity | Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate. |
| hormone-sensitive lipase activity | Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate. |
| alpha2-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein. |
| alpha-1B adrenergic receptor binding | Interacting selectively and non-covalently with an alpha-1B adrenergic receptor. |
| alpha-2C adrenergic receptor binding | Interacting selectively and non-covalently with an alpha-2C adrenergic receptor. |
| epinephrine binding | Interacting selectively and non-covalently with epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. |
| chemokine binding | Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. |
| acetyl-CoA C-acyltransferase activity | Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. |
| acetate CoA-transferase activity | |
| palmitoyl-CoA oxidase activity | Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide. |
| acetyl-CoA C-myristoyltransferase activity | |
| dopamine beta-monooxygenase activity | Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O. |
| 6,7-dihydropteridine reductase activity | Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine. |
| C-X-C chemokine binding | Interacting selectively and non-covalently with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif. |
| retinoid binding | Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. |
| all-trans-retinol binding | |
| fructose 1,6-bisphosphate 1-phosphatase activity | Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. |
| 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity | Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate. |
| heme oxygenase (decyclizing) activity | Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O. |
| macrophage colony-stimulating factor receptor binding | Interacting selectively and non-covalently with the macrophage colony-stimulating factor receptor. |
| platelet activating factor receptor activity | Combining with platelet activating factor to initiate a change in cell activity. |
| platelet-derived growth factor receptor activity | Combining with platelet-derived growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| platelet-derived growth factor beta-receptor activity | Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity. |
| dihydrolipoyl dehydrogenase activity | Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. |
| miRNA binding | Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. |
| G-rich strand telomeric DNA binding | |
| HLA-A specific activating MHC class I receptor activity | Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte. |
| gastric inhibitory polypeptide receptor binding | |
| digestive hormone activity | The action characteristic of a hormone that takes part in the digestion process. |
| lactase activity | Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose. |
| galactosylceramidase activity | Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine. |
| beta-glucosidase activity | Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. |
| phlorizin hydrolase activity | |
| nucleosome binding | Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
| NAD DNA ADP-ribosyltransferase activity | |
| NAD+-protein-serine ADP-ribosyltransferase activity | |
| NAD+- protein-aspartate ADP-ribosyltransferase activity | |
| NAD+-protein-glutamate ADP-ribosyltransferase activity | |
| NAD+-protein-tyrosine ADP-ribosyltransferase activity | |
| NAD+-protein-histidine ADP-ribosyltransferase activity | |
| NAD+-histone H2BS6 serine ADP-ribosyltransferase activity | |
| NAD+-histone H3S10 serine ADP-ribosyltransferase activity | |
| NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity | |
| arachidonate 5-lipoxygenase activity | Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate. |
| omega peptidase activity | Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups). |
| leukotriene-A4 hydrolase activity | Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4). |
| metalloaminopeptidase activity | Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity | |
| decanoate-CoA ligase activity | |
| 2 iron, 2 sulfur cluster binding | Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| acetylcholine receptor regulator activity | Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed. |
| apelin receptor binding | Interacting selectively and non-covalently with an apelin receptor. |
| amine sulfotransferase activity | |
| C3HC4-type RING finger domain binding | Interacting selectively and non-covalently with a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway. |
| adenylate cyclase activator activity | |
| double-stranded telomeric DNA binding | Interacting selectively and non-covalently with double-stranded telomere-associated DNA. |
| interleukin-8 receptor binding | Interacting selectively and non-covalently with the interleukin-8 receptor. |
| calcium-dependent protein kinase C activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol and calcium. |
| CCR1 chemokine receptor binding | Interacting selectively and non-covalently with a CCR1 chemokine receptor. |
| CCR5 chemokine receptor binding | Interacting selectively and non-covalently with a CCR5 chemokine receptor. |
| alpha-glucosidase activity | Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose. |
| RNA polymerase II general transcription initiation factor binding | Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor. |
| retinoic acid-responsive element binding | Interacting selectively and non-covalently with a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind. |
| alpha-actinin binding | Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. |
| amidase activity | Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3. |
| carboxypeptidase activity | Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide. |
| arachidonic acid epoxygenase activity | Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid. |
| anandamide 8,9 epoxidase activity | |
| anandamide 11,12 epoxidase activity | |
| anandamide 14,15 epoxidase activity | |
| minor groove of adenine-thymine-rich DNA binding | Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA). |
| dynactin binding | Interacting selectively and non-covalently with any part of a dynactin complex; dynactin is a large protein complex that activates dynein-based motor activity. |
| histone-dependent DNA binding | |
| microtubule lateral binding | |
| cAMP-dependent protein kinase inhibitor activity | Stops, prevents or reduces the activity of a cAMP-dependent protein kinase. |
| uroporphyrinogen-III synthase activity | Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III. |
| carboxylic ester hydrolase activity | Catalysis of the hydrolysis of a carboxylic ester bond. |
| high-density lipoprotein particle binding | Interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE. |
| myosin heavy chain binding | Interacting selectively and non-covalently with a heavy chain of a myosin complex. |
| myosin phosphatase activity | Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. |
| phenylethanolamine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine. |
| fructose transmembrane transporter activity | Catalysis of the transfer of fructose from one side of the membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. |
| galactose transmembrane transporter activity | |
| hexose transmembrane transporter activity | Catalysis of the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other. |
| orotate phosphoribosyltransferase activity | Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. |
| orotidine-5'-phosphate decarboxylase activity | Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP. |
| Edg-2 lysophosphatidic acid receptor binding | Interacting selectively and non-covalently with an Edg-2 lysophosphatidic acid receptor. |
| arylamine N-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. |
| acyl-CoA dehydrogenase activity | Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. |
| medium-chain-acyl-CoA dehydrogenase activity | Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12. |
| fibroblast growth factor receptor activity | Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| DNA topoisomerase type I (single strand cut, ATP-independent) activity | Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. |
| ubiquitin-like protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-SCP + Y --> Y-SCP + X, where both X-SCP and Y-SCP are covalent linkages. SCP represents a small conjugating protein. |
| vitamin D response element binding | Interacting selectively and non-covalently with the vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. |
| lithocholic acid receptor activity | Combining with lithocholic acid and transmitting the signal to initiate a change in cell activity. |
| calcitriol binding | Interacting selectively and non-covalently with calcitriol. Calcitriol (1,25-dihydroxycholecalciferol) is the hormonally active form of vitamin D3. |
| lithocholic acid binding | Interacting selectively and non-covalently with lithocholic acid. |
| pyruvate carboxylase activity | Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate. |
| coumarin 7-hydroxylase activity | Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. |
| nitric-oxide synthase binding | Interacting selectively and non-covalently with the enzyme nitric-oxide synthase. |
| formate-tetrahydrofolate ligase activity | Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. |
| methenyltetrahydrofolate cyclohydrolase activity | Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. |
| methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity | |
| methylenetetrahydrofolate dehydrogenase (NAD+) activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH. |
| methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
| formaldehyde dehydrogenase activity | Catalysis of the reaction: formaldehyde + H(2)O + NAD(+) = formate + 2 H(+) + NADH. |
| S-(hydroxymethyl)glutathione dehydrogenase activity | Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+. |
| cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
| serum response element binding | Interacting selectively and non-covalently with the serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. |
| primary miRNA binding | Interacting selectively and non-covalently with a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding. |
| ribose phosphate diphosphokinase activity | Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+). |
| ornithine decarboxylase activity | Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine. |
| purine-specific mismatch base pair DNA N-glycosylase activity | Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. |
| dinucleotide insertion or deletion binding | Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide insertion or deletion. |
| MutLalpha complex binding | Interacting selectively and non-covalently with the mismatch repair complex MutLalpha. |
| histidine-tRNA ligase activity | Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). |
| IMP dehydrogenase activity | Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+. |
| high-affinity IgG receptor activity | |
| high-affinity IgE receptor activity | |
| phosphatase activator activity | Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. |
| 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity | Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2. |
| histone deacetylase inhibitor activity | Stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. |
| peptidyl-dipeptidase activity | Catalysis of the release of C-terminal dipeptides from a polypeptide chain. |
| mitogen-activated protein kinase kinase binding | Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase. |
| bradykinin receptor binding | Interacting selectively and non-covalently with a bradykinin receptor. |
| metallodipeptidase activity | Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| motilin receptor binding | |
| metallocarboxypeptidase activity | Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| proline dipeptidase activity | |
| DNA end binding | |
| uracil DNA N-glycosylase activity | Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine. |
| 5-aminolevulinate synthase activity | Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA. |
| ribonuclease inhibitor activity | Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA. |
| CCR2 chemokine receptor binding | Interacting selectively and non-covalently with a CCR2 chemokine receptor. |
| receptor signaling protein tyrosine kinase activator activity | Increases the activity of a receptor signaling protein tyrosine kinase. |
| CCR4 chemokine receptor binding | Interacting selectively and non-covalently with a CCR4 chemokine receptor. |
| chemokine receptor antagonist activity | Interacts with chemokine receptors to reduce the action of a chemokine. |
| myosin light chain binding | Interacting selectively and non-covalently with a light chain of a myosin complex. |
| intracellularly ATP-gated chloride channel activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels. |
| translation elongation factor activity | Functions in chain elongation during polypeptide synthesis at the ribosome. |
| porphobilinogen synthase activity | Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen. |
| oncostatin-M receptor binding | Interacting selectively and non-covalently with the oncostatin-M receptor. |
| natural killer cell lectin-like receptor binding | Interacting selectively and non-covalently with a lectin-like natural killer cell receptor. |
| glycogen (starch) synthase activity | Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1). |
| glycogen synthase activity, transferring glucose-1-phosphate | Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate. |
| myo-inositol:sodium symporter activity | |
| water transmembrane transporter activity | Enables the directed movement of water (H2O) from one side of a membrane to the other. |
| glucose:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). |
| pentose transmembrane transporter activity | |
| fucose transmembrane transporter activity | |
| alpha-glucoside transmembrane transporter activity | |
| galactose:sodium symporter activity | |
| beta3-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors. |
| 3-beta-hydroxy-delta5-steroid dehydrogenase activity | Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+). |
| testosterone dehydrogenase [NAD(P)] activity | Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+. |
| 17-beta-hydroxysteroid dehydrogenase (NADP+) activity | |
| estradiol binding | |
| glycosphingolipid binding | Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. |
| dopachrome isomerase activity | Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate. |
| phenylpyruvate tautomerase activity | Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate. |
| oligo-1,6-glucosidase activity | Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose. |
| sucrose alpha-glucosidase activity | Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose. |
| dopamine neurotransmitter receptor activity, coupled via Gi/Go | Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity. |
| L-glucuronate reductase activity | Catalysis of the reaction: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH. |
| glucuronolactone reductase activity | |
| pyruvate kinase activity | Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. |
| glucose uniporter activity | |
| tyrosinase activity | Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O. |
| interleukin-1 receptor activity | Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response. |
| interleukin-2 binding | Interacting selectively and non-covalently with interleukin-2. |
| interleukin-15 receptor activity | Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| pre-mRNA intronic binding | Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA). |
| GABA receptor activity | Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms. |
| GABA-gated chloride ion channel activity | Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts. |
| aminoacylase activity | Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid. |
| indoleamine 2,3-dioxygenase activity | Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine. |
| D-amino-acid oxidase activity | Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide. |
| cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication | Interacting selectively and non-covalently with any protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells. |
| cytoskeletal protein-membrane anchor activity | |
| leukemia inhibitory factor receptor binding | Interacting selectively and non-covalently with the leukemia inhibitory factor receptor. |
| glutamate-ammonia ligase activity | Catalysis of the reaction: L-glutamate + ATP + NH(4)(+) = L-glutamine + ADP + 2 H(+) + phosphate. |
| glyceraldehyde oxidoreductase activity | Catalysis of the reaction: D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor. |
| translation release factor activity | Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. |
| phosphoglycerate mutase activity | Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate. |
| type II interferon receptor activity | Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity | Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide. |
| lactose synthase activity | Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose. |
| acid phosphatase activity | Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. |
| 5'-nucleotidase activity | Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. |
| thiamine phosphate phosphatase activity | Catalysis of the hydrolysis of thiamine phosphate. |
| lysophosphatidic acid phosphatase activity | Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol. |
| proton transmembrane transporter activity | Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. |
| histone H2B acetyltransferase activity | |
| deNEDDylase activity | Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates. |
| voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| prostaglandin E receptor activity | Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
| steroid 11-beta-monooxygenase activity | Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O. |
| NADH dehydrogenase (quinone) activity | Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol. |
| N-acetylglucosamine-6-sulfatase activity | Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. |
| vascular endothelial growth factor receptor 1 binding | Interacting selectively and non-covalently with vascular endothelial growth factor receptor 1. |
| phosphorylase kinase activity | Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. |
| exogenous lipid antigen binding | Interacting selectively and non-covalently with an exogenous lipid antigen (examples include microbial lipids and glycolipids). |
| N-acetylgalactosamine-4-sulfatase activity | Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. |
| arylsulfatase activity | Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. |
| beta-galactoside alpha-2,6-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine. |
| C2H2 zinc finger domain binding | Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion. |
| natriuretic peptide receptor activity | Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity. |
| hyaluronic acid binding | Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine. |
| dihydronicotinamide riboside quinone reductase activity | Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone. |
| fructose-2,6-bisphosphate 2-phosphatase activity | Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate. |
| 15-hydroxyprostaglandin dehydrogenase (NADP+) activity | Catalysis of the reaction: NADP(+) + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H(+) + NADPH. |
| prostaglandin-E2 9-reductase activity | Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH. |
| butyryl-CoA dehydrogenase activity | Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein. |
| platelet-derived growth factor alpha-receptor activity | Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity. |
| secondary active transmembrane transporter activity | Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Chemiosmotic sources of energy include uniport, symport or antiport. |
| antiporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). |
| beta-galactosidase activity | Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. |
| calmodulin-dependent protein phosphatase activity | Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin. |
| eukaryotic initiation factor eIF2 binding | Interacting selectively and non-covalently with eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation. |
| NADPH-hemoprotein reductase activity | Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein. |
| beta-lactamase activity | |
| dipeptidase activity | Catalysis of the hydrolysis of a dipeptide. |
| DNA-methyltransferase activity | Catalysis of the transfer of a methyl group to a DNA molecule. |
| prolactin receptor activity | Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| thyroid-stimulating hormone receptor activity | Combining with thyroid-stimulating hormone to initiate a change in cell activity. |
| P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential | Catalysis of the transfer of a solute or solutes from one side of a cardiac muscle cell plasma membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). The transfer contributes to the regulation of the plasma membrane potential. |
| short-chain fatty acid transmembrane transporter activity | Enables the directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than C6. |
| oleate transmembrane transporter activity | |
| diuretic hormone activity | The action characteristic of a diuretic hormone, any peptide hormone that, upon receptor binding, regulates water balance and fluid secretion. |
| neurexin family protein binding | Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. |
| interleukin-7 receptor activity | Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| phospholipase C activity | Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. |
| alpha-N-acetylgalactosaminidase activity | Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides. |
| GBD domain binding | Interacting selectively and non-covalently with the GTPase protein binding domain (GDB) domain of a protein. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac. |
| L-cysteine transaminase activity | Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate. |
| type I interferon receptor activity | Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families. |
| type I interferon binding | |
| collagen receptor activity | Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| gap junction hemi-channel activity | A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction. |
| gap junction channel activity involved in cardiac conduction electrical coupling | A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction. |
| acid sphingomyelin phosphodiesterase activity | |
| RNA polymerase I core promoter sequence-specific DNA binding | Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE. |
| RNA polymerase I cis-regulatory region sequence-specific DNA binding | |
| chlordecone reductase activity | Catalysis of the reaction: chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH. |
| cAMP-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP. |
| adenosylmethionine decarboxylase activity | Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2). |
| L-tyrosine:2-oxoglutarate aminotransferase activity | Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate. |
| CTP synthase activity | Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. |
| MH2 domain binding | Interacting selectively and non-covalently with the MH2 (MAD homology 2) domain of a protein. The MH2 domain is found at the carboxy terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. |
| sphingolipid activator protein activity | Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase. |
| complement component C4b receptor activity | Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| complement component C3b receptor activity | Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| protein tyrosine phosphatase activator activity | Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein. |
| NFAT protein binding | Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system. |
| placental growth factor receptor activity | Combining with placental growth factor (PlGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| hepoxilin-epoxide hydrolase activity | Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate. |
| 5'-3' DNA helicase activity | Catalysis of the unwinding of the DNA helix in the direction 5' to 3'. |
| NAD+-protein-arginine ADP-ribosyltransferase activity | |
| hemi-methylated DNA-binding | Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks. |
| 3-oxo-5-alpha-steroid 4-dehydrogenase activity | Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. |
| pituitary adenylate cyclase activating polypeptide activity | The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation. |
| interleukin-1, type I receptor binding | Interacting selectively and non-covalently with a Type I interleukin-1 receptor. |
| interleukin-1, type II receptor binding | Interacting selectively and non-covalently with a Type II interleukin-1 receptor. |
| interleukin-1 receptor antagonist activity | Blocks the binding of interleukin-1 to the interleukin-1 receptor complex. |
| interleukin-1 type I receptor antagonist activity | Blocks the binding of interleukin-1 to interleukin-1 Type I receptors. |
| interleukin-1 type II receptor antagonist activity | Blocks the binding of interleukin-1 to interleukin-1 Type II receptors. |
| 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity | Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; this reaction requires the cofactor 2,3-bisphosphoglycerate. |
| DNA ligase activity | Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+. |
| oxidized DNA binding | Interacting selectively and non-covalently with oxidized residues in DNA. |
| ADP-D-ribose modification-dependent protein binding | |
| peptidylglycine monooxygenase activity | Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O. |
| histidine decarboxylase activity | Catalysis of the reaction: L-histidine = histamine + CO2. |
| neurotrophin TRKA receptor binding | Interacting selectively and non-covalently with the neurotrophin TRKA receptor. |
| calcium-dependent phospholipase C activity | Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+. |
| erythropoietin receptor activity | Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| cell adhesion mediator activity | Any protein binding that is involved in cell adhesion. |
| DNA topoisomerase binding | Interacting selectively and non-covalently with a DNA topoisomerase. |
| glucokinase activity | Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate. |
| hexokinase activity | Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. |
| fructokinase activity | Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate. |
| mannokinase activity | Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate. |
| troponin C binding | Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex. |
| troponin T binding | Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex. |
| tumor necrosis factor receptor activity | Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function. |
| peptidyltransferase activity | |
| leukotriene-C(4) hydrolase | |
| glutathione hydrolase activity | Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. |
| eukaryotic translation initiation factor 2alpha kinase activity | Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate. |
| galactoside 2-alpha-L-fucosyltransferase activity | Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R. |
| fucosyltransferase activity | Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
| alpha-(1,2)-fucosyltransferase activity | Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage. |
| spermidine synthase activity | Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine. |
| sodium:proton antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). |
| sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential | Catalysis of the transfer of a solute or solutes from one side of a cardiac muscle cell membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). This transfer contributes to the regulation of the cardiac muscle cell plasma membrane potential. |
| DNA binding domain binding | Interacting selectively and non-covalently with the DBD, DNA binding domain, of a protein. The DNA binding domain of the vitamin D receptor, one of a family of receptors with the DBD, is split into three regions, the P, D and T boxes. Residues that are critical for target sequence selectivity form the P-box. The D-box contains residues that are important for homodimerization of class I nuclear receptors. The T-box is essential for both DNA-binding and transactivation of the VDR; this region may also be important for dimerization with RXR for class II nuclear receptors. |
| LBD domain binding | Interacting selectively and non-covalently with the LBD, the ligand binding domain found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket. |
| diamine oxidase activity | Catalysis of the reaction: a diamine + H2O + O2 = a monoamine + NH3 + hydrogen peroxide. |
| activin receptor antagonist activity | |
| thymidine phosphorylase activity | Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. |
| calcium ion transmembrane transporter activity | Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. |
| complement receptor activity | Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| cobalamin binding | Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. |
| L-serine ammonia-lyase activity | Catalysis of the reaction: L-serine = pyruvate + NH3. |
| IgM binding | Interacting selectively and non-covalently with an immunoglobulin of the IgM isotype. |
| guanine/thymine mispair binding | Interacting selectively and non-covalently with double-stranded DNA containing a G/T mispair. |
| mismatched DNA binding | Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. |
| single guanine insertion binding | Interacting selectively and non-covalently with double-stranded DNA containing a single guanine insertion or a deletion that results in an unpaired guanine. |
| dinucleotide repeat insertion binding | Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats. |
| P-type potassium:proton transporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in). |
| aromatic-L-amino-acid decarboxylase activity | Catalysis of the reaction: L-amino acid + H+ = R-H + CO2. |
| 5-hydroxy-L-tryptophan decarboxylase activity | |
| L-dopa decarboxylase activity | Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine. |
| interleukin-11 receptor binding | Interacting selectively and non-covalently with the interleukin-11 receptor. |
| calcium-dependent cysteine-type endopeptidase inhibitor activity | |
| testosterone 16-alpha-hydroxylase activity | |
| testosterone 16-beta-hydroxylase activity | |
| N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity | Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+). |
| 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity | Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R. |
| 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity | |
| alpha-(1->3)-fucosyltransferase activity | Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage. |
| monoamine oxidase activity | |
| aconitate hydratase activity | Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate. |
| iron-responsive element binding | Interacting selectively and non-covalently with the iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins. |
| 3 iron, 4 sulfur cluster binding | Interacting selectively and non-covalently with a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing. |
| 4 iron, 4 sulfur cluster binding | Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| tachykinin receptor activity | Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein. |
| N-formyl peptide receptor activity | Combining with an N-formyl peptide to initiate a change in cell activity. |
| serine-pyruvate transaminase activity | Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine. |
| alanine-glyoxylate transaminase activity | Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine. |
| transaminase activity | Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. |
| cannabinoid receptor activity | Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids. |
| 5'-deoxynucleotidase activity | |
| thymidylate 5'-phosphatase activity | |
| IMP 5'-nucleotidase activity | |
| GMP 5'-nucleotidase activity | |
| diamine N-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine. |
| N-acetyltransferase activity | Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. |
| acetyl-CoA binding | |
| H3K27me3 modified histone binding | Interacting selectively and non-covalently with a histone H3 in which the lysine residue at position 27 has been modified by trimethylation. |
| transmembrane-ephrin receptor activity | Combining with a transmembrane ephrin to initiate a change in cell activity. |
| dopamine neurotransmitter receptor activity, coupled via Gs | Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity. |
| dopamine neurotransmitter receptor activity | Combining with the neurotransmitter dopamine to initiate a change in cell activity. |
| dopamine binding | Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. |
| complement component C5a receptor activity | Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| thromboxane A2 receptor activity | Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein. |
| ryanodine-sensitive calcium-release channel activity | Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. |
| calcium-induced calcium release activity | Release of calcium ions from an intracellular vesicle on induction by increased calcium concentration. |
| O-methyltransferase activity | Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. |
| catechol O-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol. |
| histone serotonyltransferase activity | |
| histone dopaminyltransferase activity | |
| peptide histaminyltransferase activity | |
| methylmalonyl-CoA mutase activity | Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA. |
| sterol transfer activity | |
| protein-L-isoaspartate (D-aspartate) O-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. |
| histone H2AQ104 methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-glutamine = S-adenosyl-L-homocysteine + (histone)-N5-methyl-glutamine. |
| phosphoribosylamine-glycine ligase activity | Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate. |
| phosphoribosylformylglycinamidine cyclo-ligase activity | Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate. |
| phosphoribosylglycinamide formyltransferase activity | Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. |
| phosphoribosylaminoimidazole carboxylase activity | Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2). |
| phosphoribosylaminoimidazolesuccinocarboxamide synthase activity | Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate. |
| interleukin-10 receptor binding | Interacting selectively and non-covalently with the interleukin-10 receptor. |
| iduronate-2-sulfatase activity | Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin. |
| propionyl-CoA C2-trimethyltridecanoyltransferase activity | |
| G-quadruplex DNA binding | Interacting selectively and non-covalently with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome. |
| exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. |
| cyclic-GMP-AMP hydrolase activity | |
| voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated potassium channel activity involved in SA node cell action potential repolarization | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| type 1 galanin receptor binding | Interacting selectively and non-covalently with a type 1 galanin receptor. |
| type 2 galanin receptor binding | Interacting selectively and non-covalently with a type 2 galanin receptor. |
| type 3 galanin receptor binding | Interacting selectively and non-covalently with a type 3 galanin receptor. |
| ferredoxin-NADP+ reductase activity | |
| single-stranded telomeric DNA binding | Interacting selectively and non-covalently with single-stranded telomere-associated DNA. |
| cholesterol 7-alpha-monooxygenase activity | Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O. |
| luteinizing hormone receptor activity | Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity. |
| choriogonadotropin hormone receptor activity | Combining with the choriogonadotropin hormone to initiate a change in cell activity. |
| prostaglandin-endoperoxide synthase activity | Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. |
| malic enzyme activity | Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. |
| glycine dehydrogenase (decarboxylating) activity | Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2. |
| pyridoxal binding | |
| tryptophan-tRNA ligase activity | Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). |
| oxidized pyrimidine DNA binding | |
| small ribosomal subunit rRNA binding | Interacting selectively and non-covalently with the small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA. |
| taurine binding | Interacting selectively and non-covalently with taurine. |
| aminomethyltransferase activity | Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein. |
| chromo shadow domain binding | Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain. |
| adenosylhomocysteinase activity | Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. |
| nitric-oxide synthase inhibitor activity | Interacts with, and stops, prevents or reduces the activity of nitric oxide synthase. |
| inositol-1,4,5-trisphosphate 3-kinase activity | Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+). |
| HMG box domain binding | Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. |
| carnitine O-palmitoyltransferase activity | Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine. |
| thymidylate kinase activity | Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. |
| ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. |
| ribonucleoside-diphosphate reductase activity | |
| follicle-stimulating hormone receptor activity | Combining with follicle-stimulating hormone to initiate a change in cell activity. |
| dopamine:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) = dopamine(in) + Na+(in). |
| norepinephrine:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) = norepinephrine(in) + Na+(in). |
| L-alanine:2-oxoglutarate aminotransferase activity | Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate. |
| Rab geranylgeranyltransferase activity | Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family. |
| corticotropin-releasing hormone binding | Interacting selectively and non-covalently with corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland. |
| interleukin-4 receptor activity | Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| thromboxane-A synthase activity | Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2). |
| 12-hydroxyheptadecatrienoic acid synthase activity | |
| hydroperoxy icosatetraenoate dehydratase activity | |
| acetyl-CoA C-acetyltransferase activity | Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA. |
| C-acetyltransferase activity | Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule. |
| interleukin-8 receptor activity | Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| C-X-C chemokine receptor activity | Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif. |
| protein kinase regulator activity | Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein. |
| G protein-coupled receptor kinase activity | Catalysis of the reaction: ATP + G-protein coupled receptor = ADP + G-protein coupled receptor phosphate. |
| beta-adrenergic receptor kinase activity | Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor. |
| substance P receptor activity | Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity. |
| 3-mercaptopyruvate sulfurtransferase activity | Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate. |
| purine ribonucleotide binding | Interacting selectively and non-covalently with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. |
| neuropeptide Y receptor activity | Combining with neuropeptide Y to initiate a change in cell activity. |
| nuclear localization sequence binding | Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. |
| DNA (cytosine-5-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. |
| pre-mRNA intronic pyrimidine-rich binding | Interacting selectively and non-covalently with a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA). |
| isovaleryl-CoA dehydrogenase activity | Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF. |
| alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP. |
| non-sequence-specific DNA binding, bending | |
| poly-pyrimidine tract binding | Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule. |
| valine-tRNA ligase activity | Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+). |
| C-C chemokine binding | Interacting selectively and non-covalently with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. |
| HLA-E specific inhibitory MHC class Ib receptor activity | |
| activating MHC class Ib receptor activity | |
| interleukin-3 receptor activity | Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| activin receptor activity | Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta. |
| BMP receptor activity | |
| nucleoside triphosphate adenylate kinase activity | Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP. |
| nucleoside monophosphate kinase activity | Catalysis of the reaction: ATP + nucleoside phosphate = ADP + nucleoside diphosphate. |
| aryldialkylphosphatase activity | Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol. |
| phosphatidylglycerol binding | Interacting selectively and non-covalently with phosphatidylglycerol. |
| dipeptidyl-peptidase activity | Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. |
| sphingosine N-acyltransferase activity | Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine. |
| 3'-5'-DNA exonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule. |
| double-stranded DNA exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule. |
| site-specific endodeoxyribonuclease activity, specific for altered base | Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks. |
| class II DNA-(apurinic or apyrimidinic site) endonuclease activity | |
| phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands | |
| DNA-(abasic site) binding | |
| deoxyadenosine kinase activity | |
| deoxyguanosine kinase activity | Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+). |
| cytidine kinase activity | |
| aspartate carbamoyltransferase activity | Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate. |
| carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate. |
| dihydroorotase activity | Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+). |
| aspartate binding | Interacting selectively and non-covalently with aspartate, the alpha-amino-acid anion of 2-aminobutanedioic acid that has formula C4H5NO4. |
| transmembrane receptor protein tyrosine kinase adaptor activity | The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way. |
| acyloxyacyl hydrolase activity | Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid. |
| Gq/11-coupled serotonin receptor activity | Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels. |
| choline O-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA. |
| long-chain-acyl-CoA dehydrogenase activity | Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF. |
| MAP kinase tyrosine/serine/threonine phosphatase activity | Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate. |
| 11-beta-hydroxysteroid dehydrogenase (NADP+) activity | |
| NAD+ nucleosidase activity | Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose. |
| endogenous lipid antigen binding | Interacting selectively and non-covalently with an endogenous cellular lipid antigen. |
| inositol monophosphate phosphatase activity | Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate. |
| G protein-coupled adenosine receptor activity | Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| GPI-linked ephrin receptor activity | Combining with a GPI-anchored ephrin to initiate a change in cell activity. |
| histone H3K4me/H3K4me2/H3K4me3 demethylase activity | Catalysis of the removal of a methyl group from trimethylated lysine at position 4 of the histone H3 protein. |
| transketolase activity | Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor. |
| interleukin-12 beta subunit binding | Interacting selectively and non-covalently with the beta subunit of interleukin-12. |
| interleukin-27 binding | Interacting selectively and non-covalently with interleukin-27. |
| interleukin-23 receptor binding | Interacting selectively and non-covalently with the interleukin-23 receptor. |
| interleukin-12 alpha subunit binding | Interacting selectively and non-covalently with the alpha subunit of interleukin-12. |
| nitric-oxide synthase activity | Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. |
| FMN binding | Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. |
| sumo-dependent protein binding | |
| CD40 receptor binding | Interacting selectively and non-covalently with CD40, a receptor found on the surface of all B-lymphocytes. |
| intracellular cGMP-activated cation channel activity | Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts. |
| potassium ion transmembrane transporter activity | Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. |
| glycerol transmembrane transporter activity | Catalysis of the transfer of glycerol from one side of the membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. |
| nitric oxide transmembrane transporter activity | Enables the directed movement of nitric oxide, nitrogen monoxide, from one side of a membrane to the other. |
| 1-acylglycerophosphocholine O-acyltransferase activity | Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA. |
| biliverdin reductase (NAD(P)+) activity | Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+. |
| riboflavin reductase (NADPH) activity | Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+. |
| RNA polymerase III transcription regulatory region sequence-specific DNA binding | Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. |
| thioredoxin peroxidase activity | Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O. |
| D-dopachrome decarboxylase activity | Catalysis of the reaction: D-dopachrome + H(+) = 5,6-dihydroxyindole + CO(2). |
| alkyl hydroperoxide reductase activity | Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol. |
| enoyl-CoA hydratase activity | Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O. |
| uridine kinase activity | Catalysis of the reaction: ATP + uridine = ADP + UMP. |
| UMP kinase activity | Catalysis of the reaction: ATP + UMP = ADP + UDP. |
| WW domain binding | Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. |
| bradykinin receptor activity | Combining with bradykinin to initiate a change in cell activity. |
| myristoyltransferase activity | Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule. |
| vasopressin receptor activity | Combining with vasopressin to initiate a change in cell activity. |
| adenylosuccinate synthase activity | Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate. |
| gamma-aminobutyric acid:sodium:chloride symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) = gamma-aminobutyric acid(in) + Na+(in). |
| sodium:chloride symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in). |
| angiotensin type I receptor activity | An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms. |
| N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity | Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. |
| (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity | Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. |
| GTP cyclohydrolase I activity | Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate. |
| L-ornithine transmembrane transporter activity | Catalysis of the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid. |
| L-histidine transmembrane transporter activity | Catalysis of the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. |
| L-lysine transmembrane transporter activity | Catalysis of the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid. |
| benzaldehyde dehydrogenase (NAD+) activity | Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+. |
| somatostatin receptor activity | Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G-protein coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28). |
| RNA polymerase II activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| calcitonin binding |
