| Description | curated annotations of genes with molecular functions |
| Measurement | association by literature curation |
| Association | gene-molecular function associations from curated gene annotations |
| Category | structural or functional annotations |
| Resource | Gene Ontology |
| Citation(s) | |
| Last Updated | 2025 Mar 10 |
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Gene Attribute
Gene Similarity
Attribute Similarity
UMAP
3937 sets of genes performing molecular functions from the curated GO Molecular Function Annotations 2025 dataset.
| Gene Set | Description |
|---|---|
| aromatase activity | Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. |
| protein kinase binding | Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein homodimerization activity | Interacting selectively and non-covalently with an identical protein to form a homodimer. |
| ATPase binding | Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| ubiquitin protein ligase binding | Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. |
| mRNA 3'-UTR binding | Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S --> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate. Note that this may include the extension of ubiquitin chains. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
| cis-regulatory region sequence-specific DNA binding | |
| DNA-binding transcription repressor activity, RNA polymerase II-specific | |
| sequence-specific double-stranded DNA binding | |
| calcium ion binding | Interacting selectively and non-covalently with calcium ions (Ca2+). |
| calcium-dependent phospholipid binding | Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. |
| phosphatidylethanolamine binding | Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. |
| phosphatidylcholine binding | Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline. |
| phosphatidylinositol binding | Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| cadherin binding | Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion. |
| solute:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in). |
| mannose:sodium symporter activity | |
| fructose:sodium symporter activity | |
| mitochondrial ribosome binding | Interacting selectively and non-covalently with any part of a mitochondrial ribosome, a ribosome found in the mitochondrion of a eukaryotic cell. |
| ribosome binding | Interacting selectively and non-covalently with any part of a ribosome. |
| magnesium ion binding | Interacting selectively and non-covalently with magnesium (Mg) ions. |
| UDP-xylosyltransferase activity | Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule. |
| monoatomic ion channel activity | |
| GTPase activator activity | Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + phosphate. |
| protein serine/threonine kinase activator activity | Increases the activity of a protein serine/threonine kinase. |
| CARD domain binding | Interacting selectively and non-covalently with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family. |
| BH3 domain binding | Interacting selectively and non-covalently with the BH3 domain of a protein of the Bcl-2 family. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death. |
| cardiolipin binding | Interacting selectively and non-covalently with cardiolipin. |
| intracellularly calcium-gated chloride channel activity | |
| chloride channel activity | Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| calcium channel activity | Catalysis of facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| channel activity | Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules. |
| chloride channel inhibitor activity | Stops, prevents, or reduces the activity of a chloride channel. |
| ubiquitin conjugating enzyme activity | Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. |
| actin binding | Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. |
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
| fatty acid elongase activity | Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C). |
| phosphatidylinositol-5-phosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. |
| phosphatidylinositol-3-phosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. |
| SH2 domain binding | Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. |
| phosphatidylinositol-3,5-bisphosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions. |
| threonine-tRNA ligase activity | Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). |
| hydroxylysine kinase activity | Catalysis of the reaction: erythro-5-hydroxy-L-lysine + GTP = 5-phosphonooxy-L-lysine + GDP + 2 H(+). |
| microtubule binding | Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. |
| tRNA binding | Interacting selectively and non-covalently with transfer RNA. |
| iron ion binding | Interacting selectively and non-covalently with iron (Fe) ions. |
| tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity | |
| calcium oxalate binding | Interacting selectively and non-covalently with calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi. |
| racemase and epimerase activity, acting on carbohydrates and derivatives | Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. |
| L-fucose mutarotase activity | |
| fucose binding | Interacting selectively and non-covalently with fucose, the pentose 6-deoxygalactose. |
| D-ribitol-5-phosphate cytidylyltransferase activity | |
| cytidylyltransferase activity | Catalysis of the transfer of a cytidylyl group to an acceptor. |
| phosphatidylinositol 3-kinase inhibitor activity | |
| RNA endonuclease activity | |
| metal ion binding | Interacting selectively and non-covalently with any metal ion. |
| plasmanylethanolamine desaturase activity | |
| serotonin-gated monoatomic cation channel activity | |
| poly(A)-specific ribonuclease activity | Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. |
| nuclear estrogen receptor binding | |
| nuclear retinoic acid receptor binding | |
| armadillo repeat domain binding | Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation. |
| carnosine synthase activity | Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine. |
| homocarnosine synthase activity | |
| DNA-binding transcription activator activity, RNA polymerase II-specific | |
| protein tyrosine phosphatase activity | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| phosphoglycolate phosphatase activity | Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate. |
| glycerol-3-phosphatase activity | |
| metalloendopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| carboxy-lyase activity | Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. |
| sequence-specific DNA binding | Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| rRNA (cytosine-N4-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine. |
| aconitate decarboxylase activity | Catalysis of the reaction: cis-aconitate + H(+) = CO(2) + itaconate. |
| hormone activity | The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. |
| ionotropic glutamate receptor binding | Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. |
| GABA receptor binding | Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. |
| olfactory receptor activity | Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. |
| tubulin-glutamic acid ligase activity | Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule. |
| all-trans-retinol dehydrogenase (NAD+) activity | |
| cysteine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| cysteine-type deubiquitinase activity | |
| K63-linked deubiquitinase activity | |
| K48-linked deubiquitinase activity | |
| protein-glycine ligase activity, initiating | Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein. |
| ubiquitin-like ligase-substrate adaptor activity | |
| mRNA binding | Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| alpha-tubulin binding | Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin. |
| peptidase inhibitor activity | Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. |
| phosphatase binding | Interacting selectively and non-covalently with any phosphatase. |
| GABA-A receptor activity | Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels. |
| GABA-gated chloride ion channel activity | Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts. |
| double-stranded DNA binding | Interacting selectively and non-covalently with double-stranded DNA. |
| lactose binding | Interacting selectively and non-covalently with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk. |
| lysine N-methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. |
| protein-lysine N-methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. |
| methylation-dependent protein binding | |
| BMP receptor binding | Interacting selectively and non-covalently with a BMP receptor. |
| coenzyme A diphosphatase activity | |
| potassium channel activity | Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| calcium ion sensor activity | |
| phosphatidylinositol-4,5-bisphosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. |
| phosphatidylinositol-3,4,5-trisphosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions. |
| phosphatidylinositol-3,4-bisphosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions. |
| 3-hydroxyacyl-CoA dehydratase activity | Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA). |
| very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity | |
| SH3 domain binding | Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. |
| histone H3K9me2/H3K9me3 demethylase activity | |
| immunoglobulin receptor binding | Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule. |
| inward rectifier potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. |
| voltage-gated monoatomic anion channel activity | |
| mechanosensitive monoatomic cation channel activity | |
| L-lactate dehydrogenase inhibitor activity | |
| protein serine/threonine kinase inhibitor activity | Stops, prevents or reduces the activity of a protein serine/threonine kinase. |
| protein serine/threonine kinase binding | |
| estradiol 17-beta-dehydrogenase [NAD(P)+] activity | |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
| cytokine activity | Functions to control the survival, growth, differentiation and effector function of tissues and cells. |
| mitochondrial large ribosomal subunit binding | |
| alkylglycerone-phosphate synthase activity | Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion. |
| FAD binding | Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| calcium channel regulator activity | Modulates the activity of a calcium channel. |
| potassium channel regulator activity | Modulates the activity of a potassium channel. |
| sodium channel regulator activity | Modulates the activity of a sodium channel. |
| chloride channel regulator activity | Modulates the activity of a chloride channel. |
| deoxycytidine kinase activity | Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP. |
| thymidine kinase activity | Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. |
| nucleoside kinase activity | Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. |
| Wnt receptor activity | |
| protein heterodimerization activity | Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. |
| cadherin binding involved in cell-cell adhesion | |
| fatty-acyl-CoA binding | Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. |
| long-chain fatty acyl-CoA binding | Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more. |
| long-chain fatty acyl-CoA hydrolase activity | |
| small GTPase binding | Interacting selectively and non-covalently with a small monomeric GTPase. |
| ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| syntaxin binding | Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. |
| interleukin-1 binding | Interacting selectively and non-covalently with interleukin-1. |
| histone H2AXY142 phosphatase activity | |
| GAF domain binding | Interacting selectively and non-covalently with the GAF domain of a protein. |
| chemokine activity | The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. |
| CCR3 chemokine receptor binding | |
| receptor ligand activity | |
| alpha-aminoacyl-tRNA binding | |
| voltage-gated potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| sodium channel activity | Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| ligand-gated channel activity | Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
| potassium ion leak channel activity | Catalysis of the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state. |
| galactose binding | Interacting selectively and non-covalently with the aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides. |
| disaccharide binding | Interacting selectively and non-covalently with any disaccharide. Disaccharides are sugars composed of two monosaccharide units. |
| complement component C4b binding | Interacting selectively and non-covalently with the C4b product of the classical complement cascade. |
| serine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| GTP binding | Interacting selectively and non-covalently with GTP, guanosine triphosphate. |
| GDP binding | Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate. |
| myosin V binding | Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. |
| protein phosphatase binding | Interacting selectively and non-covalently with any protein phosphatase. |
| cholesterol binding | Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
| steroid sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate. |
| lipopolysaccharide immune receptor activity | |
| low-density lipoprotein particle receptor binding | Interacting selectively and non-covalently with a low-density lipoprotein receptor. |
| NADH dehydrogenase activity | Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. |
| hyaluronan synthase activity | Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP. |
| protease binding | Interacting selectively and non-covalently with any protease or peptidase. |
| death receptor activity | Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death. |
| G protein-coupled receptor activity | |
| glutamate receptor activity | Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| G protein-coupled receptor binding | |
| neuropeptide hormone activity | The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. |
| bHLH transcription factor binding | Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
| transmembrane receptor protein serine/threonine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| BMP binding | Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family. |
| BMP receptor activity | |
| copper ion binding | Interacting selectively and non-covalently with copper (Cu) ions. |
| cuprous ion binding | Interacting selectively and non-covalently with cuprous ion, copper(1+). |
| phosphatidylinositol phospholipase C activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+). |
| four-way junction DNA binding | Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. |
| Y-form DNA binding | Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end. |
| transcription cis-regulatory region binding | |
| R-SMAD binding | Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein. |
| SUMO transferase activity | Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages. |
| SUMO binding | Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO. |
| SUMO ligase activity | Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S --> X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate. |
| core promoter sequence-specific DNA binding | Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. |
| aryl hydrocarbon receptor binding | Interacting selectively and non-covalently with an aryl hydrocarbon receptor. |
| arachidonate binding | |
| deoxyribonuclease inhibitor activity | |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | |
| epidermal growth factor receptor binding | Interacting selectively and non-covalently with the epidermal growth factor receptor. |
| clathrin light chain binding | Interacting selectively and non-covalently with a clathrin light chain. |
| glutamate receptor binding | Interacting selectively and non-covalently with a glutamate receptor. |
| clathrin adaptor activity | The binding activity of a molecule that brings together clathrin and one or more other molecules, permitting them to function in a coordinated way. |
| metal-dependent deubiquitinase activity | |
| voltage-gated calcium channel activity | Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| high voltage-gated calcium channel activity | Catalysis of the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. |
| RNA polymerase II-specific DNA-binding transcription factor binding | |
| kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| Hsp90 protein binding | Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. |
| E-box binding | Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. |
| DNA-binding transcription factor binding | |
| 1-phosphatidylinositol-3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+). |
| pyruvate dehydrogenase (NAD+) activity | |
| purine nucleobase transmembrane transporter activity | Catalysis of the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other. |
| nucleoside:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in). |
| cytidine transmembrane transporter activity | |
| uridine transmembrane transporter activity | |
| pyrimidine- and adenosine-specific:sodium symporter activity | |
| aryl sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. |
| sulfotransferase activity | Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. |
| L-glutamate transmembrane transporter activity | Catalysis of the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid. |
| high-affinity L-glutamate transmembrane transporter activity | |
| extracellularly glutamate-gated chloride channel activity | |
| glutamate:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in). |
| flavin-dependent sulfhydryl oxidase activity | |
| acetyl-CoA transmembrane transporter activity | |
| GTPase regulator activity | Modulates the rate of GTP hydrolysis by a GTPase. |
| 3',5'-cyclic-AMP phosphodiesterase activity | Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. |
| 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | |
| zinc ion binding | Interacting selectively and non-covalently with zinc (Zn) ions. |
| cAMP binding | Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). |
| cGMP binding | Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). |
| TPR domain binding | Interacting selectively and non-covalently with a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices. |
| phosphate ion binding | Interacting selectively and non-covalently with phosphate. |
| 3',5'-cyclic-GMP phosphodiesterase activity | Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. |
| GTPase inhibitor activity | Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. |
| 3'-5'-RNA exonuclease activity | |
| DNA-directed RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| elongation factor-2 kinase activity | |
| chemokine receptor activity | Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. |
| chemokine receptor binding | Interacting selectively and non-covalently with any chemokine receptor. |
| CCR chemokine receptor binding | Interacting selectively and non-covalently with a CCR chemokine receptor. |
| tubulin binding | Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules. |
| mRNA 5'-UTR binding | Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule. |
| N6-methyladenosine-containing RNA reader activity | |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+). |
| 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity | |
| glial cell-derived neurotrophic factor receptor activity | Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| phosphotyrosine residue binding | |
| receptor tyrosine kinase binding | Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity. |
| beta-mannosidase activity | Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. |
| thioesterase binding | Interacting selectively and non-covalently with any thioesterase enzyme. |
| procollagen-lysine 5-dioxygenase activity | Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2. |
| sodium:phosphate symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in). |
| urate transmembrane transporter activity | Catalysis of the transfer of urate from one side of the membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. |
| transcription coregulator binding | |
| metallopeptidase activity | Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| endopeptidase activator activity | Increases the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. |
| preribosome binding | |
| aspartic-type endopeptidase inhibitor activity | Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process. |
| tau protein binding | Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. |
| RNA polymerase binding | Interacting selectively and non-covalently with an RNA polymerase molecule or complex. |
| cysteine-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| co-SMAD binding | Interacting selectively and non-covalently with a common mediator SMAD signaling protein. |
| fatty acid amide hydrolase activity | Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid. |
| monoacylglycerol lipase activity | |
| Notch binding | Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor. |
| Tat protein binding | Interacting selectively and non-covalently with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus. |
| peptidase activator activity involved in apoptotic process | Increases the activity of a peptidase that is involved in the apoptotic process. |
| frizzled binding | Interacting selectively and non-covalently with the frizzled (fz) receptor. |
| interleukin-5 receptor binding | Interacting selectively and non-covalently with the interleukin-5 receptor. |
| syndecan binding | Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells. |
| phosphatidylinositol transfer activity | |
| phosphatidic acid binding | Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. |
| snoRNA binding | Interacting selectively and non-covalently with small nucleolar RNA. |
| histone methyltransferase binding | Interacting selectively and non-covalently with a histone methyltransferase enzyme. |
| poly(A) binding | Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. |
| eukaryotic initiation factor 4E binding | Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation. |
| ribonucleoside triphosphate phosphatase activity | |
| RNA strand annealing activity | |
| RNA stem-loop binding | Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop. |
| gamma-tubulin binding | Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin. |
| ribosomal small subunit binding | Interacting selectively and non-covalently with any part of the small ribosomal subunit. |
| CTPase activity | Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction. |
| RNA nuclease activity | |
| CCR7 chemokine receptor binding | Interacting selectively and non-covalently with a CCR7 chemokine receptor. |
| O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity | Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor. |
| ubiquitin ligase activator activity | |
| quercetin 2,3-dioxygenase activity | Catalysis of the reaction: H(+) + O(2) + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO. |
| peroxisome matrix targeting signal-2 binding | Interacting selectively and non-covalently with a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F). |
| nuclear localization sequence binding | Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. |
| protein serine/threonine phosphatase activity | Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. |
| carboxylesterase activity | |
| ubiquitin-like protein ligase binding | |
| acetyl-CoA carboxylase activity | Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. |
| pyridoxal kinase activity | Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. |
| pyridoxal phosphate binding | Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
| potassium ion binding | Interacting selectively and non-covalently with potassium (K+) ions. |
| sodium ion binding | Interacting selectively and non-covalently with sodium ions (Na+). |
| lithium ion binding | Interacting selectively and non-covalently with lithium ions (Li+). |
| stearoyl-CoA 9-desaturase activity | Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O. |
| diacylglycerol diphosphate phosphatase activity | |
| phosphatidate phosphatase activity | Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. |
| sphingosine-1-phosphate phosphatase activity | Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate. |
| lipid phosphatase activity | Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate. |
| ceramide-1-phosphate phosphatase activity | |
| nuclear receptor binding | |
| MRF binding | Interacting selectively and non-covalently with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors. |
| growth hormone receptor binding | Interacting selectively and non-covalently with the growth hormone receptor. |
| insulin-like growth factor receptor binding | Interacting selectively and non-covalently with the insulin-like growth factor receptor. |
| JAK pathway signal transduction adaptor activity | The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way. |
| phosphorylation-dependent protein binding | |
| DNA polymerase binding | Interacting selectively and non-covalently with a DNA polymerase. |
| urea transmembrane transporter activity | Enables the directed movement of urea cross a membrane into, out of or within a cell, or between cells. Urea is the water soluble compound H2N-CO-NH2. |
| water channel activity | Transport systems of this type catalyze facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| glycerol channel activity | Catalysis of facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| ubiquinone binding | Interacting selectively and non-covalently with ubiquinone, a quinone derivative with a tail of isoprene units. |
| transmembrane receptor protein tyrosine phosphatase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| STAT family protein binding | |
| filamin binding | Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. |
| protein kinase inhibitor activity | Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein. |
| protein tyrosine kinase inhibitor activity | Stops, prevents or reduces the activity of a protein tyrosine kinase. |
| glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. |
| transmembrane ascorbate ferrireductase activity | |
| transcription coactivator binding | Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. |
| PDZ domain binding | Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins. |
| RNA polymerase II CTD heptapeptide repeat phosphatase activity | |
| HECT domain binding | |
| histone demethylase activity | Catalysis of the removal of a methyl group from a histone. |
| CXCR3 chemokine receptor binding | Interacting selectively and non-covalently with a the CXCR3 chemokine receptor. |
| neuropeptide receptor activity | Combining with a neuropeptide to initiate a change in cell activity. |
| G protein-coupled peptide receptor activity | |
| bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity | Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate. |
| phosphodiesterase I activity | Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides. |
| bis(5'-adenosyl)-pentaphosphatase activity | |
| nucleoside triphosphate diphosphatase activity | |
| bis(5'-adenosyl)-triphosphatase activity | Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP + 2 H(+). |
| methylated histone binding | Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. |
| outward rectifier potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force. |
| kinesin binding | Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. |
| endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. |
| metalloendopeptidase activity involved in amyloid precursor protein catabolic process | |
| ABC-type vitamin B12 transporter activity | |
| glutathione transferase activity | Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. |
| prostaglandin-E synthase activity | Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2). |
| histone H3K4 methyltransferase activity | |
| GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. |
| tRNA methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. |
| tRNA (cytidine-5-)-methyltransferase activity | |
| cysteine-type endopeptidase activator activity | |
| caspase binding | Interacting selectively and non-covalently with a caspase family protein. |
| inositol monophosphate 1-phosphatase activity | Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. |
| MAP kinase kinase activity | Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. |
| JUN kinase kinase activity | Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase. |
| acetyl-CoA hydrolase activity | Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+). |
| fatty acyl-CoA hydrolase activity | |
| medium-chain fatty acyl-CoA hydrolase activity | |
| CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity | Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+). |
| acetyltransferase activator activity | Increases the activity of an aceyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule. |
| beta-tubulin binding | Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin. |
| methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. |
| methyl-CpG binding | Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide. |
| protein-arginine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine. |
| protein-arginine omega-N symmetric methyltransferase activity | Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues. |
| histone methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue. |
| histone H4R3 methyltransferase activity | |
| histone H3 methyltransferase activity | |
| gamma-aminobutyric acid transmembrane transporter activity | Catalysis of the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA). |
| beta-2 adrenergic receptor binding | Interacting selectively and non-covalently with a beta-2 adrenergic receptor. |
| type 2 metabotropic glutamate receptor binding | |
| type 3 metabotropic glutamate receptor binding | Interacting selectively and non-covalently with a type 3 metabotropic glutamate receptor. |
| growth factor receptor binding | Interacting selectively and non-covalently with a growth factor receptor. |
| channel activator activity | |
| telomerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. |
| RNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. |
| RNA-directed RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template. |
| telomerase RNA binding | |
| template-free RNA nucleotidyltransferase | |
| androsterone dehydrogenase [NAD(P)+] activity | |
| 5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity | |
| androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity | |
| histone H3T11 kinase activity | |
| TRAIL receptor activity | |
| fucose-1-phosphate guanylyltransferase activity | Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP = diphosphate + GDP-L-fucose. |
| serine-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| tripeptidyl-peptidase activity | Catalysis of the release of an N-terminal tripeptide from a polypeptide. |
| sulfatide binding | |
| ubiquitin-like protein conjugating enzyme binding | |
| vascular endothelial growth factor receptor activity | |
| semaphorin receptor activity | Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| vascular endothelial growth factor binding | Interacting selectively and non-covalently with a vascular endothelial growth factor. |
| tumor necrosis factor receptor binding | Interacting selectively and non-covalently with the tumor necrosis factor receptor. |
| tumor necrosis factor receptor superfamily binding | Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily. |
| [heparan sulfate]-glucosamine 3-sulfotransferase activity | |
| trimethylamine receptor activity | Combining with the biogenic amine trimethylamine to initiate a change in cell activity. |
| Hsp70 protein binding | Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size. |
| mitogen-activated protein kinase kinase kinase binding | Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase. |
| ferrous iron binding | Interacting selectively and non-covalently with ferrous iron, Fe(II). |
| carboxylic acid binding | Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). |
| L-ascorbic acid binding | Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. |
| phytanoyl-CoA dioxygenase activity | Catalysis of the reaction: 2-oxoglutarate + O(2) + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO(2) + succinate. |
| 5-oxoprolinase (ATP-hydrolyzing) activity | Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate. |
| bioactive lipid receptor activity | Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes. |
| zinc ion transmembrane transporter activity | Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. |
| leukotriene-C4 synthase activity | Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4). |
| myosin binding | Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. |
| L27 domain binding | Interacting selectively and non-covalently with a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner. |
| IkappaB kinase activity | Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein. |
| transferrin receptor binding | Interacting selectively and non-covalently with the transferrin receptor. |
| histone acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. |
| histone H4K12 acetyltransferase activity | |
| ISG15 transferase activity | Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. |
| ubiquitin binding | Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
| guanylate kinase activity | Catalysis of the reaction: ATP + GMP = ADP + GDP. |
| phospholipase D activity | Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. |
| transmembrane receptor protein tyrosine kinase activator activity | Increases the activity of a transmembrane receptor protein tyrosine kinase. |
| long-chain fatty acid-CoA ligase activity | Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
| long-chain fatty acid transmembrane transporter activity | |
| very long-chain fatty acid-CoA ligase activity | Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22. |
| phytanate-CoA ligase activity | Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H(+) + phytanoyl-CoA. |
| pristanate-CoA ligase activity | Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA. |
| ornithine decarboxylase activator activity | Upregulation of the activity of the enzyme ornithine decarboxylase. |
| single-stranded DNA binding | Interacting selectively and non-covalently with single-stranded DNA. |
| poly(G) binding | Interacting selectively and non-covalently with a sequence of guanine residues in an RNA molecule. |
| P-type calcium transporter activity | |
| 1-phosphatidylinositol-3-phosphate 5-kinase activity | Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+). |
| 1-phosphatidylinositol-4-phosphate 5-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+). |
| phosphatidylinositol kinase activity | Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. |
| 1-phosphatidylinositol-5-kinase activity | |
| protein phosphatase inhibitor activity | Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins. |
| semaphorin receptor binding | Interacting selectively and non-covalently with semaphorin receptors. |
| histone H3K27me2/H3K27me3 demethylase activity | |
| phosphatidylinositol-3-phosphate phosphatase activity | |
| phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. |
| phosphatidylinositol phosphate 4-phosphatase activity | Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate. |
| phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity | Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate. |
| phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. |
| vinculin binding | Interacting selectively and non-covalently with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane. |
| phosphoribosylformylglycinamidine synthase activity | Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate. |
| microtubule minus-end binding | Interacting selectively and non-covalently with the minus end of a microtubule. |
| syntaxin-1 binding | Interacting selectively and non-covalently with the SNAP receptor syntaxin-1. |
| ribonuclease P activity | Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. |
| type I transforming growth factor beta receptor binding | Interacting selectively and non-covalently with a type I transforming growth factor beta receptor. |
| I-SMAD binding | Interacting selectively and non-covalently with an inhibitory SMAD signaling protein. |
| activin receptor binding | Interacting selectively and non-covalently with an activin receptor. |
| cholesterol transfer activity | |
| 1-acylglycerol-3-phosphate O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. |
| sphingolipid delta-4 desaturase activity | Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid. |
| retinol isomerase activity | |
| neuropeptide activity | |
| protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| virus receptor activity | Combining with a virus component and mediating entry of the virus into the cell. |
| nuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids. |
| phospholipid scramblase activity | Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism. |
| lead ion binding | Interacting selectively and non-covalently with lead (Pb) ions. |
| CD4 receptor binding | Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages. |
| mercury ion binding | Interacting selectively and non-covalently with mercury (Hg) ions. |
| estrogen response element binding | Interacting selectively and non-covalently with the estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen. |
| lysine-acetylated histone binding | Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation. |
| nuclear steroid receptor activity | |
| ephrin receptor activity | Combining with an ephrin to initiate a change in cell activity. |
| glycerone-phosphate O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA. |
| kynurenine 3-monooxygenase activity | Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+). |
| NAD(P)H oxidase H2O2-forming activity | |
| flavin adenine dinucleotide binding | Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
| cell adhesion mediator activity | |
| acetylcholine transmembrane transporter activity | Catalysis of the transfer of acetylcholine from one side of the membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. |
| monoamine transmembrane transporter activity | Catalysis of the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of the membrane to the other. |
| prostaglandin transmembrane transporter activity | Catalysis of the transfer of prostaglandins from one side of the membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. |
| L-amino acid transmembrane transporter activity | Catalysis of the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. |
| pyrimidine nucleoside transmembrane transporter activity | |
| choline transmembrane transporter activity | Catalysis of the transfer of choline from one side of the membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. |
| thiamine transmembrane transporter activity | Catalysis of the transfer of thiamine from one side of the membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. |
| putrescine transmembrane transporter activity | Catalysis of the transfer of putrescine from one side of the membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. |
| spermidine transmembrane transporter activity | |
| quaternary ammonium group transmembrane transporter activity | Catalysis of the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. |
| L-arginine transmembrane transporter activity | Catalysis of the stereospecific transfer of L-arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane. |
| CCR6 chemokine receptor binding | |
| MAP kinase activity | Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. |
| serine C-palmitoyltransferase activity | Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA. |
| titin binding | Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively. |
| FATZ binding | Interacting selectively and non-covalently with a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components. |
| titin Z domain binding | Interacting selectively and non-covalently with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34. |
| damaged DNA binding | Interacting selectively and non-covalently with damaged DNA. |
| acetylglucosaminyltransferase activity | Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. |
| linoleate 13S-lipoxygenase activity | Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. |
| arachidonate 15-lipoxygenase activity | Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate. |
| mitogen-activated protein kinase binding | Interacting selectively and non-covalently with a mitogen-activated protein kinase. |
| CD27 receptor binding | Interacting selectively and non-covalently with a CD27, a receptor found on the surface of T cells and some B cells and NK cells. |
| phosphomannomutase activity | Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate. |
| phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. |
| inositol-1,3,4-trisphosphate 4-phosphatase activity | |
| inositol-3,4-bisphosphate 4-phosphatase activity | |
| proton-transporting ATPase activity, rotational mechanism | Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. |
| DNA binding, bending | The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. |
| transcription corepressor binding | Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery. |
| prosaposin receptor activity | |
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity | Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-3,4-bisphosphate + phosphate. |
| mRNA cap binding | |
| histone deacetylase activity | Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. |
| histone deacetylase binding | Interacting selectively and non-covalently with the enzyme histone deacetylase. |
| NF-kappaB binding | Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. |
| protein decrotonylase activity | |
| histone decrotonylase activity | |
| protein de-2-hydroxyisobutyrylase activity | |
| L-leucine-2-oxoglutarate transaminase activity | |
| L-valine-2-oxoglutarate transaminase activity | |
| L-isoleucine-2-oxoglutarate transaminase activity | |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. |
| cobalt ion binding | Interacting selectively and non-covalently with a cobalt (Co) ion. |
| glutamate-gated receptor activity | |
| NMDA glutamate receptor activity | |
| glutamate-gated calcium ion channel activity | |
| taurine transmembrane transporter activity | Catalysis of the transfer of taurine from one side of the membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats. |
| monocarboxylic acid transmembrane transporter activity | Catalysis of the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. |
| lactate:proton symporter activity | |
| pyruvate transmembrane transporter activity | Catalysis of the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other. |
| copper ion transmembrane transporter activity | Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. |
| silver ion transmembrane transporter activity | |
| ABC-type xenobiotic transporter activity | |
| glucuronoside transmembrane transporter activity | |
| ABC-type glutathione S-conjugate transporter activity | |
| ABC-type bile acid transporter activity | |
| icosanoid transmembrane transporter activity | Catalysis of the transfer of icosanoids from one side of the membrane to the other. |
| guanine nucleotide transmembrane transporter activity | |
| purine nucleotide transmembrane transporter activity | Catalysis of the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other. |
| 15-hydroxyprostaglandin dehydrogenase (NAD+) activity | Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+. |
| glutathione transmembrane transporter activity | |
| CCR10 chemokine receptor binding | Interacting selectively and non-covalently with a CCR10 chemokine receptor. |
| double-stranded RNA binding | Interacting selectively and non-covalently with double-stranded RNA. |
| procollagen-proline 4-dioxygenase activity | Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2. |
| alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R. |
| sialyltransferase activity | Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. |
| chemoattractant activity | Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. |
| glycogenin glucosyltransferase activity | Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. |
| 1-alkyl-2-acetylglycerophosphocholine esterase activity | Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate. |
| phospholipase activity | Catalysis of the hydrolysis of a glycerophospholipid. |
| phospholipase A2 activity | Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. |
| calcium-dependent phospholipase A2 activity | Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+. |
| protein-cysteine S-palmitoyltransferase activity | Catalysis of the transfer of a palmitoyl group to a sulfur atom on the cysteine of a protein molecule. |
| oxysterol binding | Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol. |
| fibroblast growth factor receptor binding | Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR). |
| type 2 fibroblast growth factor receptor binding | Interacting selectively and non-covalently with the type 2 fibroblast growth factor receptor (FGFR2). |
| growth factor activity | The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. |
| kinase inhibitor activity | Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. |
| oxidized purine nucleobase lesion DNA N-glycosylase activity | Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. |
| oxidized purine DNA binding | Interacting selectively and non-covalently with oxidized purine residues in DNA. |
| 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity | Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. |
| calcidiol 1-monooxygenase activity | Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+). |
| secalciferol 1-monooxygenase activity | |
| 3-phosphoinositide-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a phosphatidylinositol-3-phosphate. |
| phospholipase activator activity | Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid. |
| phospholipase binding | Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid. |
| MHC class I protein binding | Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. |
| TAP1 binding | Interacting selectively and non-covalently with the TAP1 subunit of TAP (transporter associated with antigen processing) protein. |
| TAP2 binding | Interacting selectively and non-covalently with the TAP2 subunit of TAP (transporter associated with antigen processing) protein. |
| kinase binding | Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
| purinergic nucleotide receptor activity | Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| extracellularly ATP-gated monoatomic cation channel activity | |
| cell-cell adhesion mediator activity | |
| calcium-activated potassium channel activity | Catalysis of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. |
| intermediate conductance calcium-activated potassium channel activity | Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. |
| mRNA 5'-cap (guanine-N7-)-methyltransferase activity | |
| histone reader activity | |
| 5-methylcytosine dioxygenase activity | |
| S-adenosylmethionine-dependent methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. |
| protein kinase A catalytic subunit binding | Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A. |
| protein kinase A regulatory subunit binding | Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A. |
| nitrite reductase (NO-forming) activity | |
| retinoic acid binding | Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. |
| retinoic acid 4-hydroxylase activity | Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. |
| all-trans retinoic acid 18-hydroxylase activity | |
| leucine zipper domain binding | Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. |
| basic amino acid transmembrane transporter activity | Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7. |
| adenylylsulfate kinase activity | Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate. |
| sulfate adenylyltransferase (ATP) activity | Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate. |
| nucleotidyltransferase activity | Catalysis of the transfer of a nucleotidyl group to a reactant. |
| centromeric DNA binding | Interacting selectively and non-covalently with a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis. |
| proline dehydrogenase activity | Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor. |
| alpha,alpha-trehalase activity | Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose. |
| MAP kinase kinase kinase activity | Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. |
| galactosyltransferase activity | Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
| UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity | Catalysis of the reaction: UDP-D-galactose + a glucosylceramide = a lactosylceramide + uridine-5'-diphosphate. The glucosylceramide has sphinganine as the long chain base. |
| endopeptidase inhibitor activity | Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. |
| serine-type endopeptidase inhibitor activity | Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. |
| GPI-anchor transamidase activity | Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor. |
| GPI anchor binding | Interacting selectively and non-covalently with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes. |
| cAMP response element binding protein binding | Interacting selectively and non-covalently with the cAMP response element binding protein. |
| Roundabout binding | Interacting selectively and non-covalently with the Roundabout (ROBO) receptor, a transmembrane receptor. |
| nuclear androgen receptor binding | |
| RNA polymerase III general transcription initiation factor binding | |
| protein kinase C binding | Interacting selectively and non-covalently with protein kinase C. |
| actin monomer binding | Interacting selectively and non-covalently with monomeric actin, also known as G-actin. |
| inositol-1,3,4,5,6-pentakisphosphate kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown. |
| inositol hexakisphosphate kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown. |
| diphosphoinositol pentakisphosphate kinase activity | |
| inositol hexakisphosphate 5-kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate. |
| 5-diphosphoinositol pentakisphosphate 1-kinase activity | |
| pyrimidine nucleobase transmembrane transporter activity | Catalysis of the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other. |
| urea channel activity | Catalysis of facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| hydrogen peroxide channel activity | |
| MAP kinase kinase kinase kinase activity | Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli. |
| linear polyubiquitin binding | Interacting selectively and non-covalently with a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next. |
| patched binding | Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins. |
| LIM domain binding | Interacting selectively and non-covalently with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions. |
| disulfide oxidoreductase activity | Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. |
| transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | |
| phosphatidylinositol phosphate 5-phosphatase activity | Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate. |
| phosphatidylinositol-4-phosphate phosphatase activity | Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate. |
| inositol-1,4,5-trisphosphate 5-phosphatase activity | Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate. |
| fibroblast growth factor binding | Interacting selectively and non-covalently with a fibroblast growth factor. |
| RNA cap binding | Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. |
| alpha-1,4-glucosidase activity | Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose. |
| histone H3K9 methyltransferase activity | |
| histone H3K9 trimethyltransferase activity | |
| ubiquitin ligase inhibitor activity | |
| aldose reductase (NADPH) activity | |
| phenanthrene-9,10-epoxide hydrolase activity | Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene. |
| actinin binding | Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin. |
| low voltage-gated calcium channel activity | Catalysis of the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded. |
| voltage-gated calcium channel activity involved in AV node cell action potential | |
| voltage-gated calcium channel activity involved SA node cell action potential | Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| crossover junction DNA endonuclease activity | |
| N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. |
| glucuronosyltransferase activity | Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. |
| chloride transmembrane transporter activity | Catalysis of the transfer of chloride ions from one side of a membrane to the other. |
| iodide transmembrane transporter activity | Catalysis of the transfer of iodide ions from one side of a membrane to the other. |
| chloride:bicarbonate antiporter activity | |
| phosphatidylcholine flippase activity | |
| phosphatidylserine flippase activity | |
| voltage-gated monoatomic cation channel activity | |
| ankyrin binding | Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. |
| HNK-1 sulfotransferase activity | Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R). |
| type I activin receptor binding | Interacting selectively and non-covalently with a type I activin receptor. |
| signaling receptor complex adaptor activity | |
| JUN kinase binding | Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family. |
| 5-hydroxymethyl-dUMP N-hydrolase activity | |
| galanin receptor activity | Combining with galanin to initiate a change in cell activity. |
| orexin receptor activity | Combining with orexin to initiate a change in cell activity. |
| acetylcholine receptor binding | Interacting selectively and non-covalently with an acetylcholine receptor. |
| arsenite transmembrane transporter activity | Catalysis of the transfer of arsenite from one side of a membrane to the other. |
| histone H2A kinase activity | |
| maleylacetoacetate isomerase activity | Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate. |
| rRNA (guanine) methyltransferase activity | |
| phosphatidic acid transfer activity | |
| poly-ADP-D-ribose modification-dependent protein binding | |
| KDEL sequence binding | Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum. |
| AMP-activated protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP. |
| lipoate synthase activity | Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl. |
| ion channel inhibitor activity | Stops, prevents, or reduces the activity of an ion channel. |
| phosphatase inhibitor activity | Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. |
| potassium channel inhibitor activity | Stops, prevents, or reduces the activity of a potassium channel. |
| protein phosphatase regulator activity | Modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
| protein phosphatase 2A binding | Interacting selectively and non-covalently with the enzyme protein phosphatase 2A. |
| carnitine:O-acyl-L-carnitine antiporter activity | |
| O-acyl-L-carnitine transmembrane transporter activity | |
| asparagine-tRNA ligase activity | Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+). |
| adenine nucleotide transmembrane transporter activity | Catalysis of the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of the membrane to the other. |
| ATP transmembrane transporter activity | Catalysis of the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other. |
| ADP transmembrane transporter activity | Catalysis of the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other. |
| coenzyme A transmembrane transporter activity | Enables the directed movement of coenzyme A across a membrane into, out of or within a cell, or between cells. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. |
| FAD transmembrane transporter activity | Enables the directed movement of flavin-adenine dinucleotide (FAD) across a membrane into, out of or within a cell, or between cells. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form. |
| FMN transmembrane transporter activity | Enables the directed movement of flavine mononucleotide (FMN) into, out of or within a cell, or between cells. |
| NAD transmembrane transporter activity | |
| AMP transmembrane transporter activity | Catalysis of the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other. |
| mRNA 3'-UTR AU-rich region binding | Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule. |
| U3 snoRNA binding | Interacting selectively and non-covalently with U3 small nucleolar RNA. |
| hyalurononglucosaminidase activity | Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. |
| hyaluronoglucuronidase activity | Catalysis of the random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate. |
| N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity | |
| glucose-6-phosphate transmembrane transporter activity | Catalysis of the transfer of glucose-6-phosphate from one side of the membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6. |
| glucose 6-phosphate:phosphate antiporter activity | |
| isocitrate dehydrogenase (NAD+) activity | Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+. |
| purine nucleoside transmembrane transporter activity | Catalysis of the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other. |
| CCR1 chemokine receptor binding | Interacting selectively and non-covalently with a CCR1 chemokine receptor. |
| aminopeptidase activity | Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. |
| glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan. |
| platelet-derived growth factor receptor binding | Interacting selectively and non-covalently with the platelet-derived growth factor receptor. |
| vascular endothelial growth factor receptor binding | Interacting selectively and non-covalently with any vascular endothelial growth factor receptor. |
| keratan sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate. |
| CXCR5 chemokine receptor binding | Interacting selectively and non-covalently with a CXCR5 chemokine receptor. |
| DNA replication origin binding | Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. |
| ubiquitin-modified protein reader activity | |
| retinal dehydrogenase activity | Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal. |
| aldo-keto reductase (NADPH) activity | |
| alcohol dehydrogenase (NADP+) activity | |
| indanol dehydrogenase activity | Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+. |
| all-trans-retinol dehydrogenase (NADP+) activity | |
| heparan sulfate 6-sulfotransferase activity | |
| nuclear vitamin D receptor binding | |
| type 1 fibroblast growth factor receptor binding | Interacting selectively and non-covalently with the type 1 fibroblast growth factor receptor (FGFR1). |
| ubiquitin conjugating enzyme binding | Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins. |
| ubiquitin-specific protease binding | Interacting selectively and non-covalently with a ubiquitin-specific protease. |
| F-box domain binding | Interacting selectively and non-covalently with an F-box domain of a protein. |
| histone octamer slider activity | |
| single-stranded RNA binding | Interacting selectively and non-covalently with single-stranded RNA. |
| 3'-5' RNA helicase activity | Catalysis of the unwinding of an RNA helix in the direction 3' to 5'. |
| glycosylceramide flippase activity | |
| histone H3 acetyltransferase activity | |
| telomeric DNA binding | Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. |
| histone H3K4 demethylase activity | |
| histone H3K9 demethylase activity | |
| telomeric repeat-containing RNA binding | |
| FAD-dependent H3K4me/H3K4me3 demethylase activity | |
| monoatomic cation channel activity | |
| ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | |
| glycine-gated cation channel activity | |
| C-5 sterol desaturase activity | Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+. |
| linoleoyl-CoA desaturase activity | |
| omega-6 fatty acid desaturase activity | |
| acyl-CoA delta5-desaturase activity | |
| wide pore channel activity | Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts. |
| netrin receptor binding | |
| mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). |
| arachidonate-CoA ligase activity | Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+). |
| palmitoyl-CoA ligase activity | |
| phosphatidylinositol-4-phosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. |
| N-acetyllactosamine synthase activity | Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine. |
| UDP-galactosyltransferase activity | Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule. |
| ribosomal large subunit binding | Interacting selectively and non-covalently with any part of the larger ribosomal subunit. |
| GDP-mannose 4,6-dehydratase activity | Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O. |
| NADP+ binding | |
| glycylpeptide N-tetradecanoyltransferase activity | Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide. |
| cyclin-dependent protein serine/threonine kinase activator activity | |
| 7SK snRNA binding | Interacting selectively and non-covalently with a 7SK small nuclear RNA (7SK snRNA). |
| morphogen activity | Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient. |
| vascular endothelial growth factor receptor 2 binding | Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2. |
| RNA 7-methylguanosine cap binding | Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. |
| interleukin-1 receptor binding | Interacting selectively and non-covalently with the interleukin-1 receptor. |
| Toll-like receptor binding | Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response. |
| triacyl lipopeptide binding | Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of three acyl groups. |
| peptidoglycan binding | Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. |
| protein kinase activator activity | Increases the activity of a protein kinase, an enzyme which phosphorylates a protein. |
| polymeric immunoglobulin binding | |
| IgM binding | Interacting selectively and non-covalently with an immunoglobulin of the IgM isotype. |
| high-affinity IgM receptor activity | |
| pyruvate secondary active transmembrane transporter activity | Catalysis of the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. |
| lactate transmembrane transporter activity | Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. |
| symporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
| non-membrane spanning protein tyrosine kinase activity | Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate. |
| interleukin-12 receptor binding | Interacting selectively and non-covalently with the interleukin-12 receptor. |
| histone H3Y41 kinase activity | |
| hepatocyte growth factor binding | Interacting selectively and non-covalently with a hepatocyte growth factor. |
| UDP-glucose 6-dehydrogenase activity | Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate. |
| ATP-activated inward rectifier potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. |
| sulfonylurea receptor activity | Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| potassium channel activator activity | |
| calcium, potassium:sodium antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in). |
| protein C-terminal carboxyl O-methyltransferase activity | Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein. |
| protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. |
| lysophospholipase activity | Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. |
| calcium-independent phospholipase A2 activity | Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+. |
| intracellularly cAMP-activated cation channel activity | |
| voltage-gated sodium channel activity | Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| insulin receptor binding | Interacting selectively and non-covalently with the insulin receptor. |
| leptin receptor binding | Interacting selectively and non-covalently with the leptin receptor. |
| prostaglandin-D synthase activity | Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2). |
| dolichyl-phosphate beta-D-mannosyltransferase activity | Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate. |
| folic acid transmembrane transporter activity | |
| polyubiquitin modification-dependent protein binding | |
| clathrin heavy chain binding | Interacting selectively and non-covalently with a clathrin heavy chain. |
| myosin VI binding | Interacting selectively and non-covalently with a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments. |
| 6-phosphofructo-2-kinase activity | Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+). |
| pseudouridine synthase activity | Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. |
| box H/ACA snoRNA binding | |
| ubiquitin-like protein ligase activity | |
| RNA polymerase II CTD heptapeptide repeat kinase activity | |
| RNA polymerase II C-terminal domain binding | |
| calcitonin gene-related peptide receptor activity | Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity. |
| amylin receptor activity | |
| calcitonin gene-related peptide binding | |
| adrenomedullin receptor activity | Combining with adrenomedullin to initiate a change in cell activity. |
| adrenomedullin binding | |
| sphingomyelin phosphodiesterase activity | Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+). |
| phosphoric diester hydrolase activity | Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. |
| RNA-DNA hybrid ribonuclease activity | Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. |
| L-cystine transmembrane transporter activity | Catalysis of the transfer of L-cystine from one side of a membrane to the other. |
| solute:proton symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in). |
| mRNA guanylyltransferase activity | Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. |
| polynucleotide 5'-phosphatase activity | Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. |
| RNA guanylyltransferase activity | Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule. |
| inorganic triphosphate phosphatase activity | |
| ABC-type iron-sulfur cluster transporter activity | |
| nitric-oxide synthase binding | Interacting selectively and non-covalently with the enzyme nitric-oxide synthase. |
| phosphotransferase activity, alcohol group as acceptor | Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). |
| phosphotransferase activity, for other substituted phosphate groups | Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). |
| primary methylamine oxidase activity | |
| Rho-dependent protein serine/threonine kinase activity | |
| microtubule plus-end binding | Interacting selectively and non-covalently with the plus end of a microtubule. |
| protein tyrosine kinase binding | |
| inositol 1,3,4,5 tetrakisphosphate binding | Interacting selectively and non-covalently with inositol 1,3,4,5 tetrakisphosphate. |
| histone H4K20 demethylase activity | |
| histone H3K36 demethylase activity | |
| histone H4K20me2 reader activity | |
| P-type manganese transporter activity | |
| D-xylulokinase activity | |
| gamma-glutamylcyclotransferase activity | Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid. |
| oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. |
| extracellularly glycine-gated chloride channel activity | |
| glycine-gated chloride ion channel activity | |
| phosphatase activity | Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. |
| alkaline phosphatase activity | Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. |
| dinucleotide phosphatase activity | |
| arachidonate 12(S)-lipoxygenase activity | |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. |
| linoleate 9S-lipoxygenase activity | Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate. |
| GDP phosphatase activity | |
| nucleoside diphosphate phosphatase activity | |
| CDP phosphatase activity | |
| UDP phosphatase activity | |
| IDP phosphatase activity | |
| ADP phosphatase activity | |
| rDNA binding | Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA. |
| double-stranded methylated DNA binding | Interacting selectively and non-covalently with double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks. |
| nucleosomal DNA binding | Interacting selectively and non-covalently with the DNA portion of a nucleosome. |
| ADP-D-ribose modification-dependent protein binding | |
| GTPase binding | Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP. |
| L-valine transmembrane transporter activity | |
| neutral L-amino acid transmembrane transporter activity | |
| L-isoleucine transmembrane transporter activity | |
| L-leucine transmembrane transporter activity | Catalysis of the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid. |
| citrate (Si)-synthase activity | Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group. |
| nuclear glucocorticoid receptor binding | |
| peroxisome proliferator activated receptor binding | Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma. |
| nuclear retinoid X receptor binding | |
| nuclear thyroid hormone receptor binding | |
| nucleoside diphosphate kinase activity | Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. |
| DNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. |
| single-stranded DNA helicase activity | |
| 5'-deoxyribose-5-phosphate lyase activity | Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site. |
| ADP binding | Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate. |
| ciliary neurotrophic factor receptor binding | Interacting selectively and non-covalently with the ciliary neurotrophic factor receptor. |
| supercoiled DNA binding | Interacting selectively and non-covalently with supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA. |
| carbonate dehydratase activity | Catalysis of the reaction: H2CO3 = CO2 + H2O. |
| RS domain binding | Interacting selectively and non-covalently with an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing. |
| D-mannose binding | |
| bis(monoacylglycero)phosphate synthase activity | |
| delta(3)-delta(2)-enoyl-CoA isomerase activity | |
| lncRNA binding | |
| RISC complex binding | |
| pre-miRNA binding | Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA. |
| translation release factor activity, codon specific | A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. |
| collagen binding involved in cell-matrix adhesion | Any collagen binding that occurs as part of cell-matrix adhesion. |
| histone H3S10 kinase activity | |
| histone H3S28 kinase activity | |
| histone H2AS1 kinase activity | |
| peptidoglycan immune receptor activity | |
| glycine C-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+). |
| lipase activity | Catalysis of the hydrolysis of a lipid or phospholipid. |
| rRNA binding | Interacting selectively and non-covalently with ribosomal RNA. |
| ribosomal protein S6 kinase activity | Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP. |
| gap junction channel activity | A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. |
| 3-sulfino-L-alanine: proton, glutamate antiporter activity | |
| aspartate:glutamate, proton antiporter activity | |
| galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide. |
| intracellularly gated calcium channel activity | |
| temperature-gated cation channel activity | Catalysis of the transmembrane transfer of a cation by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism). |
| protein phosphatase 1 binding | Interacting selectively and non-covalently with the enzyme protein phosphatase 1. |
| eukaryotic initiation factor eIF2 binding | Interacting selectively and non-covalently with eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation. |
| protein phosphatase activator activity | Increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
| ribonuclease P RNA binding | Interacting selectively and non-covalently with the RNA subunit of ribonuclease P. |
| carbonyl reductase (NADPH) activity | Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+. |
| NADPH dehydrogenase (quinone) activity | |
| NADPH binding | Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
| metalloexopeptidase activity | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| delta7-sterol 5(6)-desaturase activity | |
| isocitrate dehydrogenase (NADP+) activity | Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+. |
| glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP. |
| oxysterol 7-alpha-hydroxylase activity | Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O. |
| formyltetrahydrofolate dehydrogenase activity | Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO(2) + H(+) + NADPH. |
| G protein-coupled GABA receptor activity | |
| diacylglycerol O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. |
| sterol O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester. |
| cholesterol O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA. |
| cyclin-dependent protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). |
| ATP-dependent diacylglycerol kinase activity | |
| gamma-butyrobetaine dioxygenase activity | Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O(2) = carnitine + CO(2) + succinate. |
| serine-type carboxypeptidase activity | Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| acetylcholine receptor activity | Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| peptidase activator activity | Increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. |
| tropomyosin binding | Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. |
| vitamin E binding | Interacting selectively and non-covalently with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. |
| Delta14-sterol reductase activity | Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol. |
| NADP binding | |
| 3',5'-cyclic-nucleotide phosphodiesterase activity | Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate. |
| DNA nuclease activity | |
| disordered domain specific binding | |
| (R)-carnitine transmembrane transporter activity | |
| amino-acid betaine transmembrane transporter activity | Catalysis of the transfer of betaine, the N-trimethyl derivative of an amino acid, from one side of the membrane to the other. |
| carnitine transmembrane transporter activity | Enables the directed movement of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. |
| bicarbonate transmembrane transporter activity | Catalysis of the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. |
| bicarbonate channel activity | |
| signal recognition particle binding | Interacting selectively and non-covalently with the signal recognition particle. |
| 7S RNA binding | Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). |
| cysteine-type endopeptidase inhibitor activity | Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| 5'-3' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. |
| mRNA 5'-diphosphatase activity | |
| RNA NAD+-cap (NAD+-forming) hydrolase activity | |
| ADP-ribose diphosphatase activity | Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate. |
| mono-ADP-D-ribose binding | |
| ligand-gated calcium channel activity | |
| dimethylargininase activity | Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline. |
| 3'-5' DNA helicase activity | Catalysis of the unwinding of the DNA helix in the direction 3' to 5'. |
| bubble DNA binding | Interacting selectively and non-covalently with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA. |
| telomeric D-loop binding | |
| DNA/DNA annealing activity | |
| RNA polymerase II complex binding | |
| galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity | Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein. |
| ammonium channel activity | |
| methylammonium channel activity | |
| 3-chloroallyl aldehyde dehydrogenase activity | Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid. |
| retinal binding | Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. |
| diacylglycerol-dependent serine/threonine kinase activity | |
| glutamine-fructose-6-phosphate transaminase (isomerizing) activity | Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. |
| laminin-1 binding | Interacting selectively and non-covalently with laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1. |
| mitochondrion targeting sequence binding | |
| UFM1 ligase activity | |
| mechanosensitive monoatomic ion channel activity | |
| osmolarity-sensing monoatomic cation channel activity | |
| cytoskeleton-nuclear membrane anchor activity | |
| receptor antagonist activity | Interacts with receptors to reduce the action of another ligand, the agonist. |
| latrotoxin receptor activity | Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| heparosan-N-sulfate-glucuronate 5-epimerase activity | Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate. |
| glutaminase activity | Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3. |
| ubiquitin-ubiquitin ligase activity | Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. |
| sodium-independent organic anion transmembrane transporter activity | Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. |
| histone H2AK119 ubiquitin ligase activity | |
| cyclin-dependent protein serine/threonine kinase inhibitor activity | Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. |
| snRNA binding | Interacting selectively and non-covalently with a small nuclear RNA (snRNA). |
| uridine phosphorylase activity | Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. |
| deoxyuridine phosphorylase activity | |
| amine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. |
| mechanosensitive potassium channel activity | |
| RNA polymerase II C-terminal domain phosphoserine binding | |
| sphingosine-1-phosphate receptor activity | Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein. |
| benzodiazepine receptor binding | Interacting selectively and non-covalently with the peripheral benzodiazepine receptor (PBR). |
| voltage-gated monoatomic ion channel activity | |
| netrin receptor activity involved in chemorepulsion | |
| ornithine decarboxylase inhibitor activity | The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase. |
| calcium:proton antiporter activity | |
| glycogen binding | Interacting selectively and non-covalently with glycogen. |
| O-palmitoyltransferase activity | Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule. |
| phosphatidylcholine-retinol O-acyltransferase activity | Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine. |
| satellite DNA binding | Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA. |
| DNA endonuclease activity | |
| pyrimidine-specific mismatch base pair DNA N-glycosylase activity | Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site. |
| DNA N-glycosylase activity | Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. |
| protein tyrosine/serine/threonine phosphatase activity | Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| histone H4K16 acetyltransferase activity | |
| histone H4 acetyltransferase activity | |
| histone H3K14 acetyltransferase activity | |
| histone H3K23 acetyltransferase activity | |
| histone H4K5 acetyltransferase activity | |
| histone H4K8 acetyltransferase activity | |
| histone H3K4 acetyltransferase activity | |
| interleukin-18 receptor activity | Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| solute:inorganic anion antiporter activity | |
| proton transmembrane transporter activity | |
| cyclic nucleotide binding | Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. |
| delayed rectifier potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and activation is slow. |
| phosphatidylinositol bisphosphate binding | Interacting selectively and non-covalently with phosphatidylinositol bisphosphate. |
| NAD+ poly-ADP-ribosyltransferase activity | |
| carbohydrate phosphatase activity | Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate. |
| FFAT motif binding | Interacting selectively and non-covalently with the FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family. |
| pre-mRNA binding | Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. |
| 6-phosphogluconolactonase activity | Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+). |
| bile acid transmembrane transporter activity | Catalysis of the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. |
| canalicular bile acid transmembrane transporter activity | The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. |
| NACHT domain binding | Interacting selectively and non-covalently with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs. |
| phenylalanine-tRNA ligase activity | Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). |
| histone acetyltransferase binding | Interacting selectively and non-covalently with the enzyme histone acetyltransferase. |
| second spliceosomal transesterification activity | Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. |
| pre-mRNA 3'-splice site binding | Interacting selectively and non-covalently with the pre-mRNA 3' splice site sequence. |
| telethonin binding | Interacting selectively and non-covalently with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase. |
| receptor serine/threonine kinase binding | Interacting selectively and non-covalently with a receptor that possesses protein serine/threonine kinase activity. |
| phosphoacetylglucosamine mutase activity | Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate. |
| beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R. |
| sulfurtransferase activity | Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). |
| molybdopterin-synthase sulfurtransferase activity | Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine <=> AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase. |
| 1-phosphatidylinositol binding | Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
| mannose-ethanolamine phosphotransferase activity | Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor. |
| gap junction channel activity involved in cell communication by electrical coupling | |
| cation binding | Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. |
| hexosyltransferase activity | |
| manganese ion binding | Interacting selectively and non-covalently with manganese (Mn) ions. |
| xylosyltransferase activity | Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
| sphinganine-1-phosphate aldolase activity | Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde. |
| apolipoprotein A-I binding | Interacting selectively and non-covalently with apolipoprotein A-I. |
| sphingolipid floppase activity | |
| phosphatidylcholine floppase activity | |
| phosphatidylserine floppase activity | |
| glucose-6-phosphate dehydrogenase activity | Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. |
| pantetheine hydrolase activity | Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine. |
| carbohydrate:proton symporter activity | |
| dehydroascorbic acid transmembrane transporter activity | |
| D-glucose transmembrane transporter activity | Catalysis of the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of the membrane to the other. |
| NAD+ kinase activity | Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+). |
| tyrosyl-RNA phosphodiesterase activity | Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis. |
| 5'-tyrosyl-DNA phosphodiesterase activity | Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA. |
| protein-L-histidine N-tele-methyltransferase activity | |
| sulfur dioxygenase activity | Catalysis of the reaction: sulfur + O2 + H2O = sulfite. |
| adenylate cyclase binding | Interacting selectively and non-covalently with the enzyme adenylate cyclase. |
| deubiquitinase activity | |
| protein phosphatase 2B binding | Interacting selectively and non-covalently with the enzyme protein phosphatase 2B. |
| mitogen-activated protein kinase p38 binding | Interacting selectively and non-covalently with mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation. |
| phosphatidate cytidylyltransferase activity | Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol. |
| geranylgeranyl diphosphate synthase activity | |
| U6 snRNA binding | Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA). |
| C-C chemokine receptor activity | Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. |
| heparan sulfate N-sulfotransferase activity | |
| heparan sulfate N-deacetylase activity | |
| creatine kinase activity | Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). |
| malonyl-CoA decarboxylase activity | Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2. |
| NADPH:quinone reductase activity | Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone. |
| protein-disulfide reductase (glutathione) activity | Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol. |
| UDP-sugar diphosphatase activity | Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate. |
| 3'(2'),5'-bisphosphate nucleotidase activity | Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate. |
| glutamate formimidoyltransferase activity | Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate. |
| formimidoyltetrahydrofolate cyclodeaminase activity | Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH(4)(+). |
| MHC class I receptor activity | Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules. |
| MHC class Ib receptor activity | |
| activating MHC class I receptor activity | Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte. |
| metalloendopeptidase inhibitor activity | Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. |
| DNA topoisomerase activity | Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. |
| RNA topoisomerase activity | |
| endopolyphosphatase activity | |
| diphosphoinositol-polyphosphate diphosphatase activity | Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate. |
| inositol diphosphate tetrakisphosphate diphosphatase activity | Catalysis of the reaction: inositol diphosphate tetrakisphosphate + H2O = inositol 1,3,4,5,6-pentakisphosphate + phosphate. |
| inositol diphosphate pentakisphosphate diphosphatase activity | Catalysis of the reaction: inositol diphosphate pentakisphosphate + H2O = inositol hexakisphosphate + phosphate. |
| 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity | |
| 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity | |
| cholesterol 25-hydroxylase activity | Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O. |
| interleukin-18 binding | Interacting selectively and non-covalently with interleukin-18. |
| kinase activator activity | Increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| protein kinase B binding | Interacting selectively and non-covalently with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism. |
| general transcription initiation factor binding | |
| molybdopterin synthase activity | Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis. |
| aspartic-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. |
| histone H4K20 methyltransferase activity | |
| histone H3K36 methyltransferase activity | |
| alcohol dehydrogenase (NAD+) activity | |
| L-lactate dehydrogenase activity | Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. |
| aldehyde dehydrogenase (NAD+) activity | |
| aminobutyraldehyde dehydrogenase (NAD+) activity | |
| NAD binding | |
| 3-deoxyglucosone dehydrogenase activity | |
| glutamate dehydrogenase (NAD+) activity | Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+. |
| glutamate dehydrogenase [NAD(P)+] activity | |
| NAD+ binding | |
| dihydrofolate reductase activity | Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. |
| sequence-specific mRNA binding | |
| cytochrome-b5 reductase activity, acting on NAD(P)H | |
| phenylalanine 4-monooxygenase activity | Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin. |
| ferroxidase activity | Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O. |
| oxidoreductase activity, acting on metal ions, oxygen as acceptor | |
| ornithine carbamoyltransferase activity | Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. |
| purine nucleobase binding | Interacting selectively and non-covalently with a purine nucleobase, an organic nitrogenous base with a purine skeleton. |
| purine-nucleoside phosphorylase activity | Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. |
| hypoxanthine phosphoribosyltransferase activity | Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. |
| guanine phosphoribosyltransferase activity | Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate. |
| L-aspartate:2-oxoglutarate aminotransferase activity | Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. |
| nicotinate-nucleotide adenylyltransferase activity | Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+. |
| neuropilin binding | Interacting selectively and non-covalently with a member of the neuropilin family. |
| ephrin receptor binding | Interacting selectively and non-covalently with an ephrin receptor. |
| epidermal growth factor receptor activity | |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
| protein tyrosine kinase activator activity | Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein. |
| phosphoglycerate kinase activity | Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+). |
| protein-disulfide reductase [NAD(P)H] activity | |
| adenylate kinase activity | Catalysis of the reaction: ATP + AMP = 2 ADP. |
| adenosine deaminase activity | Catalysis of the reaction: adenosine + H2O = inosine + NH3. |
| deaminase activity | Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3). |
| 2'-deoxyadenosine deaminase activity | |
| arylesterase activity | Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. |
| hydro-lyase activity | Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. |
| cyanamide hydratase activity | |
| argininosuccinate synthase activity | Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate. |
| 2'-5'-oligoadenylate synthetase activity | Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA. |
| superoxide-generating NADPH oxidase activator activity | Increases the activity of the enzyme superoxide-generating NADPH oxidase. |
| type 1 angiotensin receptor binding | Interacting selectively and non-covalently with a type 1 angiotensin receptor. |
| type 2 angiotensin receptor binding | Interacting selectively and non-covalently with a type 2 angiotensin receptor. |
| interleukin-8 binding | Interacting selectively and non-covalently with interleukin-8. |
| tumor necrosis factor binding | Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages. |
| C5L2 anaphylatoxin chemotactic receptor binding | Interacting selectively and non-covalently with a C5L2 anaphylatoxin chemotactic receptor. |
| RNA polymerase II core promoter sequence-specific DNA binding | Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery. |
| phospholipase C activator activity | |
| platelet-derived growth factor binding | Interacting selectively and non-covalently with platelet-derived growth factor. |
| low-density lipoprotein particle binding | Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. |
| type II transforming growth factor beta receptor binding | Interacting selectively and non-covalently with a type II transforming growth factor beta receptor. |
| type III transforming growth factor beta receptor binding | Interacting selectively and non-covalently with a type III transforming growth factor beta receptor. |
| deubiquitinase activator activity | Increases the activity of deubiquitinase, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences. |
| nerve growth factor receptor binding | Interacting selectively and non-covalently with the nerve growth factor receptor. |
| cysteine-type endopeptidase activator activity involved in apoptotic process | Increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process. |
| death receptor agonist activity | |
| hormone receptor binding | Interacting selectively and non-covalently with a receptor for hormones. |
| neuropeptide receptor binding | Interacting selectively and non-covalently with a neuropeptide receptor. |
| V1A vasopressin receptor binding | Interacting selectively and non-covalently with a V1A vasopressin receptor. |
| type 3 melanocortin receptor binding | Interacting selectively and non-covalently with a type 3 melanocortin receptor. |
| type 4 melanocortin receptor binding | Interacting selectively and non-covalently with a type 4 melanocortin receptor. |
| type 1 melanocortin receptor binding | Interacting selectively and non-covalently with a type 1 melanocortin receptor. |
| opioid peptide activity | Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect. |
| opioid receptor binding | Interacting selectively and non-covalently with an opioid receptor. |
| follicle-stimulating hormone activity | The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis. |
| prolactin receptor binding | Interacting selectively and non-covalently with the prolactin receptor. |
| growth hormone activity | |
| calcitonin receptor binding | Interacting selectively and non-covalently with a calcitonin receptor. |
| type 1 parathyroid hormone receptor binding | Interacting selectively and non-covalently with a type 1 parathyroid hormone receptor. |
| peptide hormone receptor binding | Interacting selectively and non-covalently with a receptor for peptide hormones. |
| gastric inhibitory polypeptide receptor binding | |
| type 1 vasoactive intestinal polypeptide receptor binding | |
| type 2 vasoactive intestinal polypeptide receptor binding | |
| growth hormone-releasing hormone activity | The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland. |
| growth hormone-releasing hormone receptor binding | Interacting selectively and non-covalently with a growth hormone-releasing hormone receptor. |
| cytokine receptor binding | Interacting selectively and non-covalently with a cytokine receptor. |
| chloramphenicol O-acetyltransferase activity | |
| erythropoietin receptor binding | Interacting selectively and non-covalently with the erythropoietin receptor. |
| interleukin-2 receptor activity | Combining with interleukin-2 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| IgA binding | Interacting selectively and non-covalently with an immunoglobulin of an IgA isotype. |
| MHC class II protein complex binding | Interacting selectively and non-covalently with the class II major histocompatibility complex. |
| interleukin-16 binding | |
| interleukin-16 receptor activity | |
| MHC class II protein binding | Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. |
| MHC class I protein complex binding | Interacting selectively and non-covalently with the class I major histocompatibility complex. |
| polymeric immunoglobulin receptor activity | Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| MHC class II receptor activity | Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| nitrite reductase activity | |
| apolipoprotein receptor binding | Interacting selectively and non-covalently with an apolipoprotein receptor. |
| apolipoprotein A-I receptor binding | Interacting selectively and non-covalently with an apolipoprotein A-I receptor. |
| chemorepellent activity | Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. |
| phosphatidylcholine-sterol O-acyltransferase activator activity | Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines. |
| high-density lipoprotein particle receptor binding | Interacting selectively and non-covalently with a high-density lipoprotein receptor. |
| metal chelating activity | The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring. |
| very-low-density lipoprotein particle receptor binding | Interacting selectively and non-covalently with a very-low-density lipoprotein receptor. |
| lipase inhibitor activity | Stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. |
| phospholipase inhibitor activity | Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. |
| lipoprotein lipase activator activity | Increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein. |
| acetylcholine-gated monoatomic cation-selective channel activity | |
| acetylcholine binding | Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. |
| monoatomic anion transmembrane transporter activity | |
| choline binding | Interacting selectively and non-covalently with choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium. |
| retinol binding | Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. |
| retinol transmembrane transporter activity | |
| oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein. |
| calcium channel inhibitor activity | Stops, prevents, or reduces the activity of a calcium channel. |
| calcidiol binding | Interacting selectively and non-covalently with calcidiol. |
| cAMP-dependent protein kinase regulator activity | Modulation of the activity of the enzyme cAMP-dependent protein kinase. |
| structural constituent of tooth enamel | The action of a molecule that contributes to the structural integrity of tooth enamel. |
| TFIIB-class transcription factor binding | Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor. |
| TBP-class protein binding | Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). |
| nuclear estrogen receptor activity | |
| G protein-coupled estrogen receptor activity | |
| tRNA-specific ribonuclease activity | Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. |
| hydroxymethylglutaryl-CoA reductase (NADPH) activity | Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH. |
| DNA nucleotidylexotransferase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). |
| bile acid binding | Interacting selectively and non-covalently with bile acids, any of a group of steroid carboxylic acids occurring in bile. |
| glucosylceramidase activity | Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. |
| scavenger receptor binding | Interacting selectively and non-covalently with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles. |
| glucosyltransferase activity | Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
| steryl-beta-glucosidase activity | |
| alpha-L-fucosidase activity | Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose. |
| fructose-bisphosphate aldolase activity | Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate. |
| fructose binding | Interacting selectively and non-covalently with the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose. |
| phospholipase A2 inhibitor activity | Stops, prevents or reduces the activity of the enzyme phospholipase A2. |
| lipase binding | Interacting selectively and non-covalently with any lipase. |
| type 8 metabotropic glutamate receptor binding | |
| type 5 metabotropic glutamate receptor binding | Interacting selectively and non-covalently with a type 5 metabotropic glutamate receptor. |
| phosphatidylcholine-sterol O-acyltransferase activity | Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine. |
| sterol ester esterase activity | |
| platelet-activating factor acetyltransferase activity | Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid. |
| ornithine aminotransferase activity | |
| angiotensin receptor activity | Combining with angiotensin to initiate a change in cell activity. |
| angiotensin type II receptor activity | An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms. |
| cytokine receptor activity | Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| macrophage migration inhibitory factor binding | Interacting selectively and non-covalently with the cytokine, macrophage migration inhibitory factor. |
| MHC class II protein binding, via antigen binding groove | Interacting selectively and non-covalently with the antigen binding groove of major histocompatibility complex class II molecules. |
| RAGE receptor binding | Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products. |
| argininosuccinate lyase activity | Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. |
| CD8 receptor binding | Interacting selectively and non-covalently with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes. |
| cadmium ion binding | Interacting selectively and non-covalently with cadmium (Cd) ions. |
| RNA polymerase I core binding | Interacting selectively and non-covalently with RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits. |
| ErbB-3 class receptor binding | Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-3/HER3. |
| nerve growth factor binding | Interacting selectively and non-covalently with nerve growth factor (NGF). |
| nerve growth factor receptor activity | Combining with nerve growth factor (NGF), to prevent apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity. |
| calcium-dependent cysteine-type endopeptidase activity | Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. |
| alpha-amylase activity | Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units. |
| chloride ion binding | Interacting selectively and non-covalently with chloride ions (Cl-). |
| protein kinase C inhibitor activity | Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein. |
| arachidonate monooxygenase activity | |
| vitamin D 24-hydroxylase activity | Catalysis of the hydroxylation of C-24 of any form of vitamin D. |
| estrogen 16-alpha-hydroxylase activity | |
| estrogen 2-hydroxylase activity | |
| long-chain fatty acid omega-hydroxylase activity | |
| long-chain fatty acid omega-1 hydroxylase activity | |
| thymidylate synthase activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. |
| voltage-gated proton channel activity | Catalysis of the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| superoxide-generating NAD(P)H oxidase activity | |
| superoxide-generating NADPH oxidase activity | Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-. |
| dolichyl-diphosphooligosaccharide-protein glycotransferase activity | Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. |
| P-type sodium:potassium-exchanging transporter activity | |
| fructose-1-phosphate aldolase activity | Catalysis of the reaction: D-fructose-1-phosphate = dihydroxyacetone phosphate + D-glyceraldehyde. |
| acetylcholine receptor activator activity | Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased. |
| PTB domain binding | Interacting selectively and non-covalently with a phosphotyrosine-binding (PTB) domain of a protein. |
| amylin binding | |
| aldehyde dehydrogenase [NAD(P)+] activity | |
| phenylacetaldehyde dehydrogenase (NAD+) activity | |
| steroid 17-alpha-monooxygenase activity | Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. |
| C-X3-C chemokine binding | |
| insulin-like growth factor I binding | Interacting selectively and non-covalently with insulin-like growth factor I. |
| neuregulin binding | |
| complement component C3b binding | Interacting selectively and non-covalently with the C3b product of the complement cascade. |
| ICAM-3 receptor activity | Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues. |
| cholesterol monooxygenase (side-chain-cleaving) activity | Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O. |
| Toll-like receptor 4 binding | Interacting selectively and non-covalently with a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response. |
| interleukin-4 receptor binding | Interacting selectively and non-covalently with the interleukin-4 receptor. |
| calcium,diacylglycerol-dependent serine/threonine kinase activity | |
| ATP:ADP antiporter activity | Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out). |
| adenine transmembrane transporter activity | Catalysis of the transfer of adenine, 6-aminopurine, from one side of a membrane to the other. |
| acrosin binding | Interacting selectively and non-covalently with acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities. |
| propionyl-CoA carboxylase activity | Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. |
| caffeine oxidase activity | Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O. |
| 4-nitrophenol 2-monooxygenase activity | |
| pyrophosphatase activity | Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments. |
| pyridoxal phosphatase activity | Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate. |
| phosphoamidase activity | |
| phosphoethanolamine phosphatase activity | Catalysis of the reaction: O-phosphoethanolamine + H2O = ethanolamine + phosphate. |
| interleukin-6 receptor binding | Interacting selectively and non-covalently with the interleukin-6 receptor. |
| endothelin A receptor binding | Interacting selectively and non-covalently with an endothelin A receptor. |
| endothelin B receptor binding | Interacting selectively and non-covalently with an endothelin B receptor. |
| cAMP response element binding | Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP. |
| long-chain fatty acid binding | Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
| oleic acid binding | Interacting selectively and non-covalently with oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid. |
| kringle domain binding | Interacting selectively and non-covalently with a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors. |
| poly(U) RNA binding | Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule. |
| proton channel activity | |
| integrin binding involved in cell-matrix adhesion | Any integrin binding that occurs as part of the process of cell-matrix adhesion. |
| histone H3T6 kinase activity | |
| uroporphyrinogen decarboxylase activity | Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. |
| insulin receptor activity | |
| insulin-like growth factor II binding | Interacting selectively and non-covalently with insulin-like growth factor II. |
| acetylcholinesterase activity | Catalysis of the reaction: acetylcholine + H2O = choline + acetate. |
| cholinesterase activity | Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion. |
| alpha-galactosidase activity | Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase. |
| phosphatidylinositol 3-kinase catalytic subunit binding | Interacting selectively and non-covalently with the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. |
| myosin II binding | Interacting selectively and non-covalently with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin. |
| histone kinase activity | Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. |
| cyclin-dependent protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). |
| eukaryotic initiation factor 4G binding | Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation. |
| phosphopyruvate hydratase activity | Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. |
| low-affinity IgE receptor activity | |
| IgE binding | Interacting selectively and non-covalently with an immunoglobulin of the IgE isotype. |
| D-glucose binding | |
| glycogen phosphorylase activity | Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate. |
| AMP binding | Interacting selectively and non-covalently with AMP, adenosine monophosphate. |
| glucose-6-phosphate isomerase activity | Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. |
| DNA-(apurinic or apyrimidinic site) endonuclease activity | |
| class I DNA-(apurinic or apyrimidinic site) endonuclease activity | |
| transforming growth factor beta binding | Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. |
| lipoprotein lipase activity | Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein. |
| triacylglycerol lipase activity | |
| phospholipase A1 activity | |
| lipoprotein particle binding | Interacting selectively and non-covalently with a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. |
| beta-N-acetylhexosaminidase activity | Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. |
| epoxide hydrolase activity | Catalysis of the reaction: an epoxide + H2O = a glycol. |
| cis-stilbene-oxide hydrolase activity | Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol. |
| tyrosine 3-monooxygenase activity | Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. |
| thiol oxidase activity | Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O. |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. |
| macrophage colony-stimulating factor receptor activity | Combining with macrophage colony-stimulating factor (M-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
| aspartic-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. |
| thrombin-activated receptor activity | |
| beta2-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors. |
| ganglioside GM1 binding | |
| ganglioside GM2 binding | |
| ganglioside GM3 binding | |
| ganglioside GT1b binding | |
| ganglioside GP1c binding | |
| bisphosphoglycerate mutase activity | Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate. |
| adenine phosphoribosyltransferase activity | Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. |
| glutamate-tRNA ligase activity | Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). |
| proline-tRNA ligase activity | Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). |
| UDP-glucose:hexose-1-phosphate uridylyltransferase activity | Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose. |
| IgG binding | Interacting selectively and non-covalently with an immunoglobulin of an IgG isotype. |
| fumarate hydratase activity | Catalysis of the reaction: (S)-malate = fumarate + H(2)O. |
| single-stranded DNA endodeoxyribonuclease activity | Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks. |
| 3' overhang single-stranded DNA endodeoxyribonuclease activity | |
| collagen V binding | Interacting selectively and non-covalently with a type V collagen trimer. |
| insulin-like growth factor receptor activity | |
| insulin-like growth factor binding | Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it. |
| 11-cis retinal binding | Interacting selectively and non-covalently with 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A. |
| G protein-coupled photoreceptor activity | |
| ligand-gated monoatomic ion channel activity | |
| neurotrophin binding | Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth. |
| G protein-coupled acetylcholine receptor activity | |
| carboxylic acid transmembrane transporter activity | Catalysis of the transfer of carboxylic acids from one side of the membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). |
| phosphatidylethanolamine flippase activity | |
| ceramide floppase activity | |
| aromatic amino acid transmembrane transporter activity | Catalysis of the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring. |
| L-alanine transmembrane transporter activity | Catalysis of the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid. |
| beta-glucuronidase activity | Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate. |
| 6-phosphofructokinase activity | Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate. |
| asparagine synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. |
| steroid Delta-isomerase activity | Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid. |
| all-trans retinal binding | Interacting selectively and non-covalently with all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A. |
| benzaldehyde dehydrogenase (NAD+) activity | Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+. |
| hydroxymethylbilane synthase activity | Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+). |
| exopeptidase activity | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. |
| type II activin receptor binding | Interacting selectively and non-covalently with a type II activin receptor. |
| pyruvate dehydrogenase (acetyl-transferring) activity | Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. |
| opsonin receptor activity | Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| beta-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. |
| beta1-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors. |
| alpha-2A adrenergic receptor binding | Interacting selectively and non-covalently with an alpha-2A adrenergic receptor. |
| myosin II heavy chain binding | Interacting selectively and non-covalently with a heavy chain of a myosin II complex. |
| U1 snRNA binding | Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA). |
| low-affinity IgG receptor activity | |
| steroid hydroxylase activity | Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. |
| vitamin D3 25-hydroxylase activity | Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O. |
| testosterone 6-beta-hydroxylase activity | Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O. |
| 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity | |
| steroid 21-monooxygenase activity | Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O. |
| 17-hydroxyprogesterone 21-hydroxylase activity | |
| progesterone 21-hydroxylase activity | |
| interleukin-3 receptor binding | Interacting selectively and non-covalently with the interleukin-3 receptor. |
| sulfuric ester hydrolase activity | Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2. |
| ciliary neurotrophic factor receptor activity | Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| interleukin-6 receptor activity | Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| interleukin-6 binding | Interacting selectively and non-covalently with interleukin-6. |
| ciliary neurotrophic factor binding | Interacting selectively and non-covalently with the cytokine ciliary neurotrophic factor. |
| Gi/o-coupled serotonin receptor activity | |
| G protein-coupled serotonin receptor activity | |
| receptor-receptor interaction | |
| serotonin receptor activity | Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. |
| acetylesterase activity | Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate. |
| diacylglycerol lipase activity | |
| alpha2-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein. |
| alpha-1B adrenergic receptor binding | Interacting selectively and non-covalently with an alpha-1B adrenergic receptor. |
| alpha-2C adrenergic receptor binding | Interacting selectively and non-covalently with an alpha-2C adrenergic receptor. |
| chemokine binding | Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. |
| acetyl-CoA C-acyltransferase activity | Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. |
| acetate CoA-transferase activity | |
| palmitoyl-CoA oxidase activity | Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide. |
| acetyl-CoA C-myristoyltransferase activity | |
| dopamine beta-monooxygenase activity | Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O. |
| dinitrosyl-iron complex binding | Interacting selectively and non-covalently with a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO. |
| 6,7-dihydropteridine reductase activity | Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine. |
| C-X-C chemokine binding | Interacting selectively and non-covalently with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif. |
| retinoid binding | Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. |
| all-trans-retinol binding | |
| fructose 1,6-bisphosphate 1-phosphatase activity | Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. |
| adenylate cyclase regulator activity | Modulates the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate. |
| 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity | Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate. |
| heme oxygenase (decyclizing) activity | Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O. |
| macrophage colony-stimulating factor receptor binding | Interacting selectively and non-covalently with the macrophage colony-stimulating factor receptor. |
| platelet activating factor receptor activity | Combining with platelet activating factor to initiate a change in cell activity. |
| platelet-derived growth factor receptor activity | |
| platelet-derived growth factor beta-receptor activity | Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity. |
| branched-chain alpha-keto acid dehydrogenase activity | |
| dihydrolipoyl dehydrogenase (NADH) activity | |
| miRNA binding | Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. |
| G-rich strand telomeric DNA binding | |
| HLA-A specific activating MHC class I receptor activity | Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte. |
| digestive hormone activity | The action characteristic of a hormone that takes part in the digestion process. |
| lactase activity | Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose. |
| galactosylceramidase activity | Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine. |
| beta-glucosidase activity | Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. |
| phlorizin hydrolase activity | |
| NAD DNA ADP-ribosyltransferase activity | |
| NAD+-protein-serine ADP-ribosyltransferase activity | |
| NAD+-protein-aspartate ADP-ribosyltransferase activity | |
| NAD+-protein-glutamate ADP-ribosyltransferase activity | |
| NAD+-protein-tyrosine ADP-ribosyltransferase activity | |
| NAD+-protein-histidine ADP-ribosyltransferase activity | |
| NAD+-histone H2BS6 serine ADP-ribosyltransferase activity | |
| NAD+-histone H3S10 serine ADP-ribosyltransferase activity | |
| NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity | |
| arachidonate 5-lipoxygenase activity | Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate. |
| omega peptidase activity | Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups). |
| leukotriene-A4 hydrolase activity | Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4). |
| metalloaminopeptidase activity | Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| decanoate-CoA ligase activity | |
| 2 iron, 2 sulfur cluster binding | Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| acetylcholine receptor regulator activity | Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed. |
| apelin receptor binding | Interacting selectively and non-covalently with an apelin receptor. |
| amine sulfotransferase activity | |
| C3HC4-type RING finger domain binding | Interacting selectively and non-covalently with a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway. |
| adenylate cyclase activator activity | |
| double-stranded telomeric DNA binding | Interacting selectively and non-covalently with double-stranded telomere-associated DNA. |
| interleukin-8 receptor binding | Interacting selectively and non-covalently with the interleukin-8 receptor. |
| CCR5 chemokine receptor binding | Interacting selectively and non-covalently with a CCR5 chemokine receptor. |
| alpha-glucosidase activity | Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose. |
| RNA polymerase II general transcription initiation factor binding | |
| retinoic acid-responsive element binding | Interacting selectively and non-covalently with a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind. |
| alpha-actinin binding | Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. |
| amidase activity | Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3. |
| channel inhibitor activity | Stops, prevents, or reduces the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. |
| carboxypeptidase activity | Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide. |
| arachidonate epoxygenase activity | |
| anandamide 8,9 epoxidase activity | |
| anandamide 11,12 epoxidase activity | |
| anandamide 14,15 epoxidase activity | |
| minor groove of adenine-thymine-rich DNA binding | |
| dynactin binding | Interacting selectively and non-covalently with any part of a dynactin complex; dynactin is a large protein complex that activates dynein-based motor activity. |
| histone-dependent DNA binding | |
| microtubule lateral binding | |
| cAMP-dependent protein kinase inhibitor activity | Stops, prevents or reduces the activity of a cAMP-dependent protein kinase. |
| uroporphyrinogen-III synthase activity | Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III. |
| carboxylic ester hydrolase activity | Catalysis of the hydrolysis of a carboxylic ester bond. |
| high-density lipoprotein particle binding | Interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE. |
| growth hormone receptor activity | |
| myosin heavy chain binding | Interacting selectively and non-covalently with a heavy chain of a myosin complex. |
| myosin phosphatase activity | Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. |
| phenylethanolamine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine. |
| fructose transmembrane transporter activity | Catalysis of the transfer of fructose from one side of the membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. |
| galactose transmembrane transporter activity | |
| hexose transmembrane transporter activity | Catalysis of the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other. |
| orotate phosphoribosyltransferase activity | Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. |
| orotidine-5'-phosphate decarboxylase activity | Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP. |
| acyltransferase activity, transferring groups other than amino-acyl groups | |
| Edg-2 lysophosphatidic acid receptor binding | Interacting selectively and non-covalently with an Edg-2 lysophosphatidic acid receptor. |
| arylamine N-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. |
| N-hydroxyarylamine O-acetyltransferase activity | |
| acyl-CoA dehydrogenase activity | Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. |
| medium-chain fatty acyl-CoA dehydrogenase activity | |
| fibroblast growth factor receptor activity | |
| DNA topoisomerase type I (single strand cut, ATP-independent) activity | |
| vitamin D response element binding | Interacting selectively and non-covalently with the vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. |
| bile acid nuclear receptor activity | |
| calcitriol binding | Interacting selectively and non-covalently with calcitriol. Calcitriol (1,25-dihydroxycholecalciferol) is the hormonally active form of vitamin D3. |
| lithocholic acid binding | Interacting selectively and non-covalently with lithocholic acid. |
| pyruvate carboxylase activity | Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate. |
| coumarin 7-hydroxylase activity | Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. |
| formate-tetrahydrofolate ligase activity | Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. |
| methenyltetrahydrofolate cyclohydrolase activity | Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. |
| methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity | |
| methylenetetrahydrofolate dehydrogenase (NAD+) activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH. |
| methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
| formaldehyde dehydrogenase (NAD+) activity | |
| S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity | |
| cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
| serum response element binding | Interacting selectively and non-covalently with the serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. |
| primary miRNA binding | Interacting selectively and non-covalently with a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding. |
| ribose phosphate diphosphokinase activity | Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+). |
| ornithine decarboxylase activity | Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine. |
| purine-specific mismatch base pair DNA N-glycosylase activity | Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. |
| dinucleotide insertion or deletion binding | Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide insertion or deletion. |
| MutLalpha complex binding | Interacting selectively and non-covalently with the mismatch repair complex MutLalpha. |
| histidine-tRNA ligase activity | Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). |
| IMP dehydrogenase activity | Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+. |
| high-affinity IgG receptor activity | |
| high-affinity IgE receptor activity | |
| phosphatase activator activity | Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. |
| 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity | Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2. |
| histone deacetylase inhibitor activity | Stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. |
| peptidyl-dipeptidase activity | Catalysis of the release of C-terminal dipeptides from a polypeptide chain. |
| mitogen-activated protein kinase kinase binding | Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase. |
| bradykinin receptor binding | Interacting selectively and non-covalently with a bradykinin receptor. |
| metallodipeptidase activity | Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| motilin receptor binding | |
| metallocarboxypeptidase activity | Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| proline dipeptidase activity | |
| DNA end binding | |
| uracil DNA N-glycosylase activity | Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine. |
| 5-aminolevulinate synthase activity | Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA. |
| ribonuclease inhibitor activity | Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA. |
| CCR2 chemokine receptor binding | Interacting selectively and non-covalently with a CCR2 chemokine receptor. |
| receptor signaling protein tyrosine kinase activator activity | Increases the activity of a receptor signaling protein tyrosine kinase. |
| CCR4 chemokine receptor binding | Interacting selectively and non-covalently with a CCR4 chemokine receptor. |
| chemokine receptor antagonist activity | Interacts with chemokine receptors to reduce the action of a chemokine. |
| myosin light chain binding | Interacting selectively and non-covalently with a light chain of a myosin complex. |
| intracellularly ATP-gated chloride channel activity | |
| protein tyrosine phosphatase activator activity | Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein. |
| ferric iron binding | Interacting selectively and non-covalently with ferric iron, Fe(III). |
| porphobilinogen synthase activity | Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen. |
| oncostatin-M receptor binding | Interacting selectively and non-covalently with the oncostatin-M receptor. |
| natural killer cell lectin-like receptor binding | Interacting selectively and non-covalently with a lectin-like natural killer cell receptor. |
| alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity | |
| glycogen synthase activity, transferring glucose-1-phosphate | Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate. |
| myo-inositol:sodium symporter activity | |
| water transmembrane transporter activity | Enables the directed movement of water (H2O) from one side of a membrane to the other. |
| D-glucose:sodium symporter activity | |
| pentose transmembrane transporter activity | |
| fucose transmembrane transporter activity | |
| alpha-glucoside transmembrane transporter activity | |
| galactose:sodium symporter activity | |
| beta3-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors. |
| 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity | |
| testosterone dehydrogenase [NAD(P)+] activity | |
| 17-beta-hydroxysteroid dehydrogenase (NADP+) activity | |
| estradiol binding | |
| glycosphingolipid binding | Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. |
| dopachrome isomerase activity | Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate. |
| phenylpyruvate tautomerase activity | Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate. |
| oligo-1,6-glucosidase activity | Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose. |
| sucrose alpha-glucosidase activity | Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose. |
| dopamine neurotransmitter receptor activity, coupled via Gi/Go | Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity. |
| L-glucuronate reductase activity | Catalysis of the reaction: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH. |
| glucuronolactone reductase activity | |
| pyruvate kinase activity | Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. |
| D-glucose uniporter activity | |
| tyrosinase activity | |
| interleukin-1 receptor activity | Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response. |
| interleukin-2 binding | Interacting selectively and non-covalently with interleukin-2. |
| interleukin-15 receptor activity | Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| pre-mRNA intronic binding | Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA). |
| GABA receptor activity | Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms. |
| aminoacylase activity | Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid. |
| indoleamine 2,3-dioxygenase activity | Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine. |
| D-amino-acid oxidase activity | Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide. |
| cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication | Interacting selectively and non-covalently with any protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells. |
| cytoskeletal protein-membrane anchor activity | |
| leukemia inhibitory factor receptor binding | Interacting selectively and non-covalently with the leukemia inhibitory factor receptor. |
| glutamine synthetase activity | |
| glyceraldehyde oxidoreductase activity | Catalysis of the reaction: D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor. |
| phosphoglycerate mutase activity | Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate. |
| type II interferon receptor activity | |
| beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity | Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide. |
| lactose synthase activity | Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose. |
| acid phosphatase activity | Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. |
| 5'-nucleotidase activity | Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. |
| thiamine phosphate phosphatase activity | Catalysis of the hydrolysis of thiamine phosphate. |
| lysophosphatidic acid phosphatase activity | Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol. |
| histone H2B acetyltransferase activity | |
| deNEDDylase activity | |
| voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| prostaglandin E receptor activity | Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. |
| 3'-5' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. |
| steroid 11-beta-monooxygenase activity | Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O. |
| NADH:ubiquinone reductase (non-electrogenic) activity | |
| N-acetylglucosamine-6-sulfatase activity | Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. |
| vascular endothelial growth factor receptor 1 binding | Interacting selectively and non-covalently with vascular endothelial growth factor receptor 1. |
| phosphorylase kinase activity | Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. |
| exogenous lipid antigen binding | Interacting selectively and non-covalently with an exogenous lipid antigen (examples include microbial lipids and glycolipids). |
| N-acetylgalactosamine-4-sulfatase activity | Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. |
| arylsulfatase activity | Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. |
| beta-galactoside alpha-2,6-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine. |
| C2H2 zinc finger domain binding | Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion. |
| natriuretic peptide receptor activity | Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity. |
| hyaluronic acid binding | Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine. |
| dihydronicotinamide riboside quinone reductase activity | Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone. |
| fructose-2,6-bisphosphate 2-phosphatase activity | Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate. |
| 15-hydroxyprostaglandin dehydrogenase (NADP+) activity | Catalysis of the reaction: NADP(+) + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H(+) + NADPH. |
| prostaglandin E2 9-reductase activity | |
| short-chain fatty acyl-CoA dehydrogenase activity | |
| platelet-derived growth factor alpha-receptor activity | Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity. |
| antiporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). |
| beta-galactosidase activity | Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. |
| calmodulin-dependent protein phosphatase activity | Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin. |
| NADPH-hemoprotein reductase activity | Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein. |
| beta-lactamase activity | |
| dipeptidase activity | Catalysis of the hydrolysis of a dipeptide. |
| DNA-methyltransferase activity | Catalysis of the transfer of a methyl group to a DNA molecule. |
| prolactin receptor activity | Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| thyroid-stimulating hormone receptor activity | Combining with thyroid-stimulating hormone to initiate a change in cell activity. |
| P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential | |
| short-chain fatty acid transmembrane transporter activity | |
| oleate transmembrane transporter activity | |
| diuretic hormone activity | The action characteristic of a diuretic hormone, any peptide hormone that, upon receptor binding, regulates water balance and fluid secretion. |
| neurexin family protein binding | Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. |
| interleukin-7 receptor activity | Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| phospholipase C activity | Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. |
| alpha-N-acetylgalactosaminidase activity | Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides. |
| GBD domain binding | Interacting selectively and non-covalently with the GTPase protein binding domain (GDB) domain of a protein. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac. |
| L-cysteine transaminase activity | |
| type I interferon receptor activity | Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families. |
| type I interferon binding | |
| collagen receptor activity | Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| gap junction hemi-channel activity | A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction. |
| gap junction channel activity involved in cardiac conduction electrical coupling | A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction. |
| acid sphingomyelin phosphodiesterase activity | |
| RNA polymerase I core promoter sequence-specific DNA binding | |
| RNA polymerase I cis-regulatory region sequence-specific DNA binding | |
| chlordecone reductase activity | Catalysis of the reaction: chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH. |
| cAMP-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP. |
| protein serine kinase activity | |
| adenosylmethionine decarboxylase activity | Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2). |
| L-tyrosine-2-oxoglutarate transaminase activity | |
| CTP synthase activity | Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. |
| MH2 domain binding | Interacting selectively and non-covalently with the MH2 (MAD homology 2) domain of a protein. The MH2 domain is found at the carboxy terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. |
| sphingolipid activator protein activity | Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase. |
| complement component C4b receptor activity | Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| complement component C3b receptor activity | Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| NFAT protein binding | Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system. |
| placental growth factor receptor activity | |
| hepoxilin-epoxide hydrolase activity | Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate. |
| 5'-3' DNA helicase activity | Catalysis of the unwinding of the DNA helix in the direction 5' to 3'. |
| NAD+-protein-arginine ADP-ribosyltransferase activity | |
| phospholipase D activator activity | |
| hemi-methylated DNA-binding | Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks. |
| 3-oxo-5-alpha-steroid 4-dehydrogenase activity | Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. |
| pituitary adenylate cyclase activating polypeptide activity | The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation. |
| interleukin-1, type I receptor binding | Interacting selectively and non-covalently with a Type I interleukin-1 receptor. |
| interleukin-1, type II receptor binding | Interacting selectively and non-covalently with a Type II interleukin-1 receptor. |
| interleukin-1 receptor antagonist activity | Blocks the binding of interleukin-1 to the interleukin-1 receptor complex. |
| interleukin-1 type I receptor antagonist activity | Blocks the binding of interleukin-1 to interleukin-1 Type I receptors. |
| interleukin-1 type II receptor antagonist activity | Blocks the binding of interleukin-1 to interleukin-1 Type II receptors. |
| DNA ligase activity | Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+. |
| oxidized DNA binding | Interacting selectively and non-covalently with oxidized residues in DNA. |
| peptidylglycine monooxygenase activity | Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O. |
| histidine decarboxylase activity | Catalysis of the reaction: L-histidine = histamine + CO2. |
| neurotrophin TRKA receptor binding | Interacting selectively and non-covalently with the neurotrophin TRKA receptor. |
| calcium-dependent phospholipase C activity | Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+. |
| erythropoietin receptor activity | Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| DNA topoisomerase binding | Interacting selectively and non-covalently with a DNA topoisomerase. |
| glucokinase activity | Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate. |
| hexokinase activity | Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. |
| fructokinase activity | Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate. |
| mannokinase activity | Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate. |
| troponin C binding | Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex. |
| troponin T binding | Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex. |
| tumor necrosis factor receptor activity | |
| leukotriene-C(4) hydrolase | |
| glutathione hydrolase activity | Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. |
| eukaryotic translation initiation factor 2alpha kinase activity | Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate. |
| galactoside 2-alpha-L-fucosyltransferase activity | Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R. |
| fucosyltransferase activity | Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
| alpha-(1,2)-fucosyltransferase activity | Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage. |
| spermidine synthase activity | Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine. |
| sodium:proton antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). |
| DNA binding domain binding | |
| LBD domain binding | Interacting selectively and non-covalently with the LBD, the ligand binding domain found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket. |
| putrescine oxidase activity | |
| diamine oxidase activity | Catalysis of the reaction: a diamine + H2O + O2 = a monoamine + NH3 + hydrogen peroxide. |
| histamine oxidase activity | Catalysis of the reaction: histamine + H2O + O2 = imidazole-4-acetaldehyde + NH3 + hydrogen peroxide + H+. |
| activin receptor antagonist activity | |
| thymidine phosphorylase activity | Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. |
| calcium ion transmembrane transporter activity | Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. |
| complement receptor activity | Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| L-serine ammonia-lyase activity | Catalysis of the reaction: L-serine = pyruvate + NH3. |
| threonine deaminase activity | |
| substance P receptor binding | Interacting selectively and non-covalently with a substance P receptor. |
| neuromedin K receptor binding | |
| substance K receptor binding | |
| guanine/thymine mispair binding | Interacting selectively and non-covalently with double-stranded DNA containing a G/T mispair. |
| mismatched DNA binding | Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. |
| single guanine insertion binding | Interacting selectively and non-covalently with double-stranded DNA containing a single guanine insertion or a deletion that results in an unpaired guanine. |
| dinucleotide repeat insertion binding | Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats. |
| P-type potassium:proton transporter activity | |
| aromatic-L-amino-acid decarboxylase activity | Catalysis of the reaction: L-amino acid + H+ = R-H + CO2. |
| 5-hydroxy-L-tryptophan decarboxylase activity | |
| L-dopa decarboxylase activity | Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine. |
| interleukin-11 receptor binding | Interacting selectively and non-covalently with the interleukin-11 receptor. |
| calcium-dependent cysteine-type endopeptidase inhibitor activity | |
| testosterone 16-alpha-hydroxylase activity | |
| testosterone 16-beta-hydroxylase activity | |
| N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity | Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+). |
| 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity | Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R. |
| 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity | |
| alpha-(1->3)-fucosyltransferase activity | Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage. |
| monoamine oxidase activity | |
| aconitate hydratase activity | Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate. |
| iron-responsive element binding | Interacting selectively and non-covalently with the iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins. |
| iron-sulfur cluster binding | Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. |
| 3 iron, 4 sulfur cluster binding | Interacting selectively and non-covalently with a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing. |
| 4 iron, 4 sulfur cluster binding | Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| tachykinin receptor activity | Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein. |
| N-formyl peptide receptor activity | Combining with an N-formyl peptide to initiate a change in cell activity. |
| L-serine-pyruvate transaminase activity | |
| alanine-glyoxylate transaminase activity | Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine. |
| transaminase activity | Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. |
| cannabinoid receptor activity | Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids. |
| 5'-deoxynucleotidase activity | |
| thymidylate 5'-phosphatase activity | |
| IMP 5'-nucleotidase activity | |
| GMP 5'-nucleotidase activity | |
| diamine N-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine. |
| N-acetyltransferase activity | Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. |
| acetyl-CoA binding | |
| histone H3K27me3 reader activity | |
| histone H4K16ac reader activity | |
| glycerol-3-phosphate dehydrogenase (NAD+) activity | |
| transmembrane-ephrin receptor activity | Combining with a transmembrane ephrin to initiate a change in cell activity. |
| dopamine neurotransmitter receptor activity, coupled via Gs | Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity. |
| dopamine neurotransmitter receptor activity | Combining with the neurotransmitter dopamine to initiate a change in cell activity. |
| complement component C5a receptor activity | Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| thromboxane A2 receptor activity | Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein. |
| ryanodine-sensitive calcium-release channel activity | Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. |
| calcium-induced calcium release activity | Release of calcium ions from an intracellular vesicle on induction by increased calcium concentration. |
| succinate dehydrogenase (quinone) activity | |
| O-methyltransferase activity | Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. |
| catechol O-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol. |
| histone serotonyltransferase activity | |
| histone dopaminyltransferase activity | |
| peptide histaminyltransferase activity | |
| methylmalonyl-CoA mutase activity | Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA. |
| sterol transfer activity | |
| protein-L-isoaspartate (D-aspartate) O-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. |
| histone H2AQ104 methyltransferase activity | |
| phosphoribosylamine-glycine ligase activity | Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate. |
| phosphoribosylformylglycinamidine cyclo-ligase activity | Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate. |
| phosphoribosylglycinamide formyltransferase activity | Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. |
| phosphoribosylaminoimidazole carboxylase activity | Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2). |
| phosphoribosylaminoimidazolesuccinocarboxamide synthase activity | Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate. |
| interleukin-10 receptor binding | Interacting selectively and non-covalently with the interleukin-10 receptor. |
| iduronate-2-sulfatase activity | Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin. |
| propionyl-CoA C2-trimethyltridecanoyltransferase activity | |
| phosphatidylcholine transfer activity | |
| G-quadruplex DNA binding | Interacting selectively and non-covalently with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome. |
| exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. |
| cyclic-GMP-AMP hydrolase activity | |
| voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated potassium channel activity involved in SA node cell action potential repolarization | Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| type 1 galanin receptor binding | Interacting selectively and non-covalently with a type 1 galanin receptor. |
| type 2 galanin receptor binding | Interacting selectively and non-covalently with a type 2 galanin receptor. |
| type 3 galanin receptor binding | Interacting selectively and non-covalently with a type 3 galanin receptor. |
| ferredoxin-NADP+ reductase activity | |
| single-stranded telomeric DNA binding | Interacting selectively and non-covalently with single-stranded telomere-associated DNA. |
| cholesterol 7-alpha-monooxygenase activity | Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O. |
| luteinizing hormone receptor activity | Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity. |
| choriogonadotropin hormone receptor activity | Combining with the choriogonadotropin hormone to initiate a change in cell activity. |
| AMP deaminase activity | Catalysis of the reaction: AMP + H2O = IMP + NH3. |
| prostaglandin-endoperoxide synthase activity | Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. |
| malic enzyme activity | Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. |
| glycine dehydrogenase (decarboxylating) activity | Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2. |
| pyridoxal binding | |
| tryptophan-tRNA ligase activity | Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). |
| oxidized pyrimidine DNA binding | |
| small ribosomal subunit rRNA binding | Interacting selectively and non-covalently with the small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA. |
| taurine binding | Interacting selectively and non-covalently with taurine. |
| aminomethyltransferase activity | Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein. |
| chromo shadow domain binding | Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain. |
| adenosylhomocysteinase activity | Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. |
| nitric-oxide synthase inhibitor activity | Interacts with, and stops, prevents or reduces the activity of nitric oxide synthase. |
| inositol-1,4,5-trisphosphate 3-kinase activity | Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+). |
| HMG box domain binding | Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. |
| carnitine O-palmitoyltransferase activity | Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine. |
| dTMP kinase activity | |
| ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. |
| ribonucleoside-diphosphate reductase activity | |
| follicle-stimulating hormone receptor activity | Combining with follicle-stimulating hormone to initiate a change in cell activity. |
| dopamine:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) = dopamine(in) + Na+(in). |
| norepinephrine:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) = norepinephrine(in) + Na+(in). |
| IgA receptor activity | |
| L-alanine:2-oxoglutarate aminotransferase activity | Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate. |
| Rab geranylgeranyltransferase activity | Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family. |
| corticotropin-releasing hormone binding | Interacting selectively and non-covalently with corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland. |
| interleukin-4 receptor activity | Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| endothelin receptor activity | Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| thromboxane-A synthase activity | Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2). |
| 12-hydroxyheptadecatrienoic acid synthase activity | |
| hydroperoxy icosatetraenoate dehydratase activity | |
| acetyl-CoA C-acetyltransferase activity | Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA. |
| C-acetyltransferase activity | Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule. |
| interleukin-8 receptor activity | Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| C-X-C chemokine receptor activity | Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif. |
| protein kinase regulator activity | Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein. |
| G protein-coupled receptor kinase activity | |
| beta-adrenergic receptor kinase activity | Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor. |
| substance P receptor activity | Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity. |
| 3-mercaptopyruvate sulfurtransferase activity | Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate. |
| acetylation-dependent protein binding | |
| purine ribonucleotide binding | Interacting selectively and non-covalently with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. |
| neuropeptide Y receptor activity | Combining with neuropeptide Y to initiate a change in cell activity. |
| DNA (cytosine-5-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. |
| pre-mRNA intronic pyrimidine-rich binding | Interacting selectively and non-covalently with a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA). |
| 3-methylbutanoyl-CoA dehydrogenase activity | |
| alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP. |
| non-sequence-specific DNA binding, bending | |
| poly-pyrimidine tract binding | Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule. |
| valine-tRNA ligase activity | Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+). |
| C-C chemokine binding | Interacting selectively and non-covalently with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. |
| protein-RNA sequence-specific adaptor activity | |
| inhibitory MHC class Ib receptor activity | |
| HLA-E specific inhibitory MHC class Ib receptor activity | |
| activating MHC class Ib receptor activity | |
| interleukin-3 receptor activity | Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| activin receptor activity | |
| activin receptor activity, type I | Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals. |
| activin receptor activity, type II | Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor. |
| nucleoside triphosphate adenylate kinase activity | Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP. |
| nucleoside monophosphate kinase activity | |
| aryldialkylphosphatase activity | Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol. |
| acyl-L-homoserine-lactone lactonohydrolase activity | |
| phosphatidylglycerol binding | Interacting selectively and non-covalently with phosphatidylglycerol. |
| tau-protein kinase activity | Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. |
| dipeptidyl-peptidase activity | Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. |
| sphingosine N-acyltransferase activity | Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine. |
| 3'-5'-DNA exonuclease activity | |
| double-stranded DNA exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule. |
| site-specific endodeoxyribonuclease activity, specific for altered base | Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks. |
| class II DNA-(apurinic or apyrimidinic site) endonuclease activity | |
| phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands | |
| DNA-(abasic site) binding | |
| deoxyadenosine kinase activity | |
| deoxyguanosine kinase activity | Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+). |
| cytidine kinase activity | |
| aspartate carbamoyltransferase activity | Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate. |
| carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate. |
| dihydroorotase activity | Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+). |
| transmembrane receptor protein tyrosine kinase adaptor activity | The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way. |
| phosphatidylinositol 3-kinase regulator activity | Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
| phosphatidylinositol 3-kinase activator activity | |
| acyloxyacyl hydrolase activity | Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid. |
| Gq/11-coupled serotonin receptor activity | Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels. |
| choline O-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA. |
| long-chain fatty acyl-CoA dehydrogenase activity | |
| MAP kinase tyrosine/serine/threonine phosphatase activity | Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate. |
| 11-beta-hydroxysteroid dehydrogenase (NADP+) activity | |
| NAD+ nucleosidase activity, cyclic ADP-ribose generating | |
| endogenous lipid antigen binding | Interacting selectively and non-covalently with an endogenous cellular lipid antigen. |
| inositol monophosphate phosphatase activity | Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate. |
| G protein-coupled adenosine receptor activity | |
| GPI-linked ephrin receptor activity | Combining with a GPI-anchored ephrin to initiate a change in cell activity. |
| histone H3K4me/H3K4me2/H3K4me3 demethylase activity | |
| transketolase activity | Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor. |
| interleukin-12 beta subunit binding | Interacting selectively and non-covalently with the beta subunit of interleukin-12. |
| interleukin-27 binding | Interacting selectively and non-covalently with interleukin-27. |
| interleukin-23 receptor binding | Interacting selectively and non-covalently with the interleukin-23 receptor. |
| interleukin-12 alpha subunit binding | Interacting selectively and non-covalently with the alpha subunit of interleukin-12. |
| nitric-oxide synthase activity | Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. |
| FMN binding | Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. |
| CD40 receptor binding | Interacting selectively and non-covalently with CD40, a receptor found on the surface of all B-lymphocytes. |
| intracellularly cGMP-activated cation channel activity | |
| potassium ion transmembrane transporter activity | Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. |
| glycerol transmembrane transporter activity | Catalysis of the transfer of glycerol from one side of the membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. |
| nitric oxide transmembrane transporter activity | Enables the directed movement of nitric oxide, nitrogen monoxide, from one side of a membrane to the other. |
| 1-acylglycerophosphocholine O-acyltransferase activity | Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA. |
| biliverdin reductase [NAD(P)+] activity | |
| riboflavin reductase (NADPH) activity | Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+. |
| RNA polymerase III transcription regulatory region sequence-specific DNA binding | |
| thioredoxin peroxidase activity | Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O. |
| D-dopachrome decarboxylase activity | Catalysis of the reaction: D-dopachrome + H(+) = 5,6-dihydroxyindole + CO(2). |
| NADH-dependent peroxiredoxin activity | |
| enoyl-CoA hydratase activity | Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O. |
| 3-hydroxypropionyl-CoA dehydratase activity | |
| uridine kinase activity | Catalysis of the reaction: ATP + uridine = ADP + UMP. |
| UMP kinase activity | Catalysis of the reaction: ATP + UMP = ADP + UDP. |
| WW domain binding | Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. |
| bradykinin receptor activity | Combining with bradykinin to initiate a change in cell activity. |
| myristoyltransferase activity | Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule. |
| vasopressin receptor activity | Combining with vasopressin to initiate a change in cell activity. |
| adenylosuccinate synthase activity | Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate. |
| gamma-aminobutyric acid:sodium:chloride symporter activity | |
| sodium:chloride symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in). |
| angiotensin type I receptor activity | An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms. |
| N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity | Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. |
| (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity | |
| GTP cyclohydrolase I activity | Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate. |
| L-ornithine transmembrane transporter activity | Catalysis of the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid. |
| L-histidine transmembrane transporter activity | Catalysis of the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. |
| L-lysine transmembrane transporter activity | Catalysis of the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid. |
| somatostatin receptor activity | Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G-protein coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28). |
| calcitonin binding | Interacting selectively and non-covalently with calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid. |
| calcitonin receptor activity | Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| calcitonin family receptor activity | Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity. |
| G protein-coupled neurotensin receptor activity | |
| Rab GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. |
| methionine adenosyltransferase activity | Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. |
| 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity | |
| carbamoyl-phosphate synthase (ammonia) activity | Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate. |
| N,N-dimethylaniline monooxygenase activity | Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. |
| hypotaurine monooxygenase activity | |
| low-affinity D-glucose:sodium symporter activity | |
| amino acid:sodium symporter activity | |
| taurine:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in). |
| alanine transmembrane transporter activity | Catalysis of the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid. |
| serotonin:sodium:chloride symporter activity | |
| 3-hydroxyisobutyrate dehydrogenase activity | Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. |
| IMP cyclohydrolase activity | Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide. |
| cytidine deaminase activity | Catalysis of the reaction: cytidine + H2O = uridine + NH3. |
| phosphoserine residue binding | |
| inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity | Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. |
| angiotensin receptor binding | Interacting selectively and non-covalently with an angiotensin receptor. |
| D1 dopamine receptor binding | Interacting selectively and non-covalently with a D1 dopamine receptor. |
| glycerol kinase activity | Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+). |
| cholecystokinin receptor activity | Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone. |
| gastrin receptor activity | Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. |
| type B gastrin/cholecystokinin receptor binding | Interacting selectively and non-covalently with a type B gastrin/cholecystokinin receptor. |
| 1-phosphatidylinositol-3-kinase regulator activity | Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity. |
| pituitary adenylate cyclase-activating polypeptide receptor activity | |
| vasoactive intestinal polypeptide receptor activity | Combining with vasoactive intestinal polypeptide to initiate a change in cell activity. |
| melanocortin receptor activity | Combining with melanocortin to initiate a change in cell activity. |
| melanocyte-stimulating hormone receptor activity | Combining with melanocyte-stimulating hormone to initiate a change in cell activity. |
| chemokine (C-C motif) ligand 7 binding | Interacting selectively and non-covalently with chemokine (C-C motif) ligand 7. |
| chemokine (C-C motif) ligand 5 binding | Interacting selectively and non-covalently with chemokine (C-C motif) ligand 5. |
| chemokine (C-C motif) ligand 19 binding | Interacting selectively and non-covalently with chemokine (C-C motif) ligand 19. |
| chemokine (C-C motif) ligand 21 binding | Interacting selectively and non-covalently with chemokine (C-C motif) ligand 21. |
| C-C motif chemokine 19 receptor activity | Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| C-C motif chemokine 21 receptor activity | Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| rhodopsin kinase activity | Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin. |
| pyrroline-5-carboxylate reductase activity | Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. |
| calcium:sodium antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in). |
| 4-hydroxyphenylpyruvate dioxygenase activity | Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. |
| interleukin-5 receptor activity | Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| cystathionine gamma-lyase activity | Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+. |
| L-cystine L-cysteine-lyase (deaminating) | Catalysis of the reaction: L-cystine + H2O <=> pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide. |
| oleoyl-CoA ligase activity | |
| dUTP diphosphatase activity | Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate. |
| ABC-type fatty-acyl-CoA transporter activity | |
| mannosidase activity | Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. |
| N-acetylgalactosamine-6-sulfatase activity | Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate. |
| ribonuclease A activity | |
| glycine hydroxymethyltransferase activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. |
| aldehyde-lyase activity | Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. |
| mannose-6-phosphate isomerase activity | Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. |
| corticotrophin-releasing factor receptor activity | Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity. |
| RING-like zinc finger domain binding | Interacting selectively and non-covalently with a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain. |
| complement component C3a binding | |
| proteinase activated receptor binding | Interacting selectively and non-covalently with a proteinase activated receptor. |
| non-membrane spanning protein tyrosine phosphatase activity | Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. |
| calcium sensitive guanylate cyclase activator activity | Increases the activity of guanylate cyclase in response to a change in calcium ion concentration. |
| sepiapterin reductase (NADP+) activity | |
| adrenomedullin receptor binding | Interacting selectively and non-covalently with an adrenomedullin receptor. |
| alpha1-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. |
| histamine receptor activity | Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. |
| beta-endorphin receptor activity | Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC). |
| morphine receptor activity | Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein. |
| apelin receptor activity | |
| mechanoreceptor activity | |
| L-iduronidase activity | Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate. |
| voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | |
| cystathionine beta-synthase activity | |
| voltage-gated chloride channel activity | Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| phosphoenolpyruvate carboxykinase (GTP) activity | Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2. |
| protein serine kinase activity (using GTP as donor) | |
| 4-alpha-glucanotransferase activity | Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan. |
| amylo-alpha-1,6-glucosidase activity | Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present. |
| glucose-6-phosphatase activity | Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate. |
| P-type divalent copper transporter activity | |
| glutathione disulfide oxidoreductase activity | Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor. |
| choline kinase activity | Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+). |
| ethanolamine kinase activity | Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine. |
| hydroxymethylglutaryl-CoA lyase activity | Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA. |
| thyroid hormone transmembrane transporter activity | Catalysis of the transfer of thyroid hormones from one side of the membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. |
| chitinase activity | Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. |
| gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling | |
| gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling | |
| gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling | A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction. |
| gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling | |
| gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling | |
| MAP-kinase scaffold activity | The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently. |
| coproporphyrinogen oxidase activity | Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX. |
| 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity | Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate = 8-oxo-7,8-dihydroguanosine phosphate + diphosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription. |
| dATP diphosphatase activity | |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. |
| 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity | Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. |
| ATP diphosphatase activity | Catalysis of the reaction: ATP + H2O = AMP + diphosphate. |
| 2-hydroxy-ATP hydrolase activity | |
| 2-hydroxy-dATP hydrolase activity | |
| mitochondrial promoter sequence-specific DNA binding | |
| phosphoglucomutase activity | Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate. |
| transforming growth factor beta receptor activity, type I | Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals. |
| transforming growth factor beta receptor activity | |
| sterol response element binding | Interacting selectively and non-covalently with the sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism. |
| GMP reductase activity | Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH. |
| testosterone 17-beta-dehydrogenase (NADP+) activity | Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione. |
| 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity | |
| testosterone dehydrogenase (NAD+) activity | Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH. |
| transforming growth factor beta receptor activity, type II | Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor. |
| prostaglandin receptor activity | Combining with a prostaglandin (PG) to initiate a change in cell activity. |
| UDP-glycosyltransferase activity | Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. |
| phosphatidylinositol N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol. |
| transaldolase activity | |
| phospholipase D inhibitor activity | Stops, prevents or reduces the activity of a phospholipase D, an enzyme that catalyzes the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. |
| ubiquitin-modified histone reader activity | |
| histone H2AK127 ubiquitin ligase activity | |
| histone H2AK129 ubiquitin ligase activity | |
| gamma-glutamyl carboxylase activity | Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide. |
| 5'-3' RNA helicase activity | Catalysis of the unwinding of an RNA helix in the direction 5' to 3'. |
| double-stranded DNA helicase activity | |
| cyclin-dependent protein kinase activating kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK). |
| kainate selective glutamate receptor activity | An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist. |
| 5'-flap endonuclease activity | Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. |
| flap endonuclease activity | Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis. |
| chemoattractant activity involved in axon guidance | |
| calcium- and calmodulin-responsive adenylate cyclase activity | Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin. |
| leukemia inhibitory factor receptor activity | Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| oncostatin-M receptor activity | Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| interleukin-27 receptor activity | Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| WD40-repeat domain binding | Interacting selectively and non-covalently with a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain. |
| thrombopoietin receptor activity | |
| nicotinamide N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine. |
| pyridine N-methyltransferase activity | |
| aldehyde oxidase activity | Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide. |
| ethanol binding | Interacting selectively and non-covalently with ethanol, CH(3)-CH(2)-OH. |
| MutSalpha complex binding | Interacting selectively and non-covalently with the mismatch repair complex MutSalpha. |
| peroxisome membrane class-1 targeting sequence binding | Interacting selectively and non-covalently with a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner. |
| L-malate dehydrogenase (NAD+) activity | |
| 3-hydroxyacyl-CoA dehydrogenase activity | Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+). |
| methionyl-initiator methionine tRNA binding | |
| G protein-coupled opioid receptor activity | |
| G protein-coupled enkephalin receptor activity | |
| dynorphin receptor activity | Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin. |
| nociceptin receptor activity | Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein. |
| protein binding involved in heterotypic cell-cell adhesion | Interacting selectively and non-covalently with any protein or protein complex contributing to the adhesion of two different types of cells. |
| receptor tyrosine kinase-like orphan receptor binding | Interacting selectively and non-covalently with the receptor tyrosine kinase-like orphan receptor (Ror). |
| protein-N-terminal amino-acid acetyltransferase activity | |
| acetyltransferase activity | Catalysis of the transfer of an acetyl group to an acceptor molecule. |
| protein serine/threonine phosphatase inhibitor activity | Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. |
| acylglycerol O-acyltransferase activity | Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. |
| retinyl-palmitate esterase activity | |
| mono-olein transacylation activity | Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol. |
| diolein transacylation activity | Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein. |
| glycine-tRNA ligase activity | Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). |
| isoleucine-tRNA ligase activity | Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+). |
| folate:monoatomic anion antiporter activity | |
| methotrexate transmembrane transporter activity | |
| 2',3'-cyclic GMP-AMP binding | |
| cyclic-GMP-AMP transmembrane transporter activity | |
| diacylglycerol-dependent, calcium-independent serine/threonine kinase activity | |
| purine-rich negative regulatory element binding | Interacting selectively and non-covalently with a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes. |
| intramolecular oxidoreductase activity, transposing C=C bonds | Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears. |
| AMPA glutamate receptor activity | |
| ligand-gated monoatomic cation channel activity | |
| prostaglandin H2 endoperoxidase reductase activity | |
| prostaglandin D2 11-ketoreductase activity | Catalysis of the reaction: prostaglandin D2 + H+ + NADPH -> 11-epi-prostaglandin F2alpha + NADP+. |
| ketoreductase activity | Catalysis of the reduction of a ketone group to form the corresponding alcohol. |
| 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity | Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate. |
| ketosteroid monooxygenase activity | Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate. |
| Delta4-3-oxosteroid 5beta-reductase activity | Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+. |
| inositol hexakisphosphate binding | Interacting selectively and non-covalently with inositol hexakisphosphate. |
| RNA polymerase III type 1 promoter sequence-specific DNA binding | |
| RNA polymerase III type 2 promoter sequence-specific DNA binding | |
| RNA polymerase III type 3 promoter sequence-specific DNA binding | |
| TFIIIC-class transcription factor complex binding | |
| 1-phosphatidylinositol 4-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+). |
| histidine ammonia-lyase activity | Catalysis of the reaction: L-histidine = urocanate + NH3. |
| interleukin-12 receptor activity | Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| interleukin-23 binding | Interacting selectively and non-covalently with interleukin-23. |
| interleukin-23 receptor activity | Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| methylenetetrahydrofolate reductase (NAD(P)H) activity | Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+. |
| L-aspartate transmembrane transporter activity | Catalysis of the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid. |
| cysteine transmembrane transporter activity | Catalysis of the transfer of cysteine from one side of the membrane to the other. |
| D-aspartate transmembrane transporter activity | |
| L-glutamine transmembrane transporter activity | Catalysis of the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid. |
| L-proline transmembrane transporter activity | Catalysis of the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid. |
| L-serine transmembrane transporter activity | Catalysis of the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid. |
| L-threonine transmembrane transporter activity | Catalysis of the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid. |
| L-hydroxyproline transmembrane transporter activity | Catalysis of the transfer of L-hydroxyproline from one side of a membrane to the other. |
| guanylate cyclase regulator activity | Modulates the activity of guanylate cyclase. |
| prostaglandin F receptor activity | Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity. |
| acyl-CoA oxidase activity | Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide. |
| carnitine O-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA. |
| glucagon-like peptide 1 receptor activity | |
| single thymine insertion binding | Interacting selectively and non-covalently with double-stranded DNA containing a single thymine insertion or a deletion that results in an unpaired thymine. |
| biotinidase activity | Catalysis of the reaction: biotin amide + H2O = biotin + NH3. |
| glycerol-3-phosphate dehydrogenase (quinone) activity | |
| interleukin-15 receptor binding | Interacting selectively and non-covalently with the interleukin-15 receptor. |
| nicotinamide phosphoribosyltransferase activity | Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide. |
| HLA-B specific inhibitory MHC class I receptor activity | Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte. |
| MHC class Ib protein binding | Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules. |
| intronic transcription regulatory region sequence-specific DNA binding | Interacting selectively and non-covalently with an intronic DNA sequence that regulates the transcription of the transcript it is contained within. |
| troponin I binding | Interacting selectively and non-covalently with troponin I, the inhibitory subunit of the troponin complex. |
| aspartoacylase activity | Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate. |
| ABC-type sterol transporter activity | |
| short-chain 2-methyl fatty acyl-CoA dehydrogenase activity | |
| JUN kinase activity | Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors. |
| peptide:proton symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in). Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement. |
| tripeptide transmembrane transporter activity | |
| dipeptide transmembrane transporter activity | |
| rRNA (cytosine-C5-)-methyltransferase activity | |
| adipokinetic hormone receptor activity | |
| adipokinetic hormone binding | |
| protein phosphorylated amino acid binding | Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein. |
| cyclin-dependent protein kinase activating kinase regulator activity | |
| S-methyltransferase activity | Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule. |
| acetylserotonin O-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine. |
| 5S rRNA binding | Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. |
| glucosamine-6-phosphate deaminase activity | Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+). |
| sodium channel inhibitor activity | Stops, prevents, or reduces the activity of a sodium channel. |
| phosphothreonine residue binding | |
| 3-hydroxyanthranilate 3,4-dioxygenase activity | Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+). |
| O-acyltransferase activity | Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. |
| ceramide 1-phosphate binding | Interacting selectively and non-covalently with ceramide 1-phosphate. |
| benzodiazepine receptor activity | Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity. |
| glucagon receptor activity | Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| secretin receptor activity | Combining with secretin to initiate a change in cell activity. |
| G protein-coupled olfactory receptor activity | |
| glutamine-tRNA ligase activity | Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). |
| G protein-coupled ADP receptor activity | |
| G protein-coupled purinergic nucleotide receptor activity | |
| G protein-coupled ATP receptor activity | |
| xanthine dehydrogenase activity | Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+. |
| xanthine oxidase activity | Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide. |
| hypoxanthine dehydrogenase activity | |
| creatine transmembrane transporter activity | Enables the directed movement of creatine across a membrane. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. |
| creatine:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in). |
| melatonin receptor activity | Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin. |
| CXCR chemokine receptor binding | Interacting selectively and non-covalently with a chemokine receptor in the CXCR family. |
| glycine transmembrane transporter activity | Catalysis of the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid. |
| glycine:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in). |
| malate dehydrogenase (decarboxylating) (NADP+) activity | Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. |
| oxaloacetate decarboxylase activity | Catalysis of the reaction: oxaloacetate = pyruvate + CO2. |
| extracellularly glycine-gated ion channel activity | |
| leptin receptor activity | |
| 1-phosphatidylinositol-5-phosphate 4-kinase activity | Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. |
| lanosterol synthase activity | Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus. |
| calcium-dependent protein serine/threonine phosphatase activity | Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions. |
| glutamate-cysteine ligase activity | Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate. |
| glutamate-cysteine ligase catalytic subunit binding | Interacting selectively and non-covalently with the catalytic subunit of glutamate-cysteine ligase. |
| G-protein activated inward rectifier potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. |
| gastric inhibitory peptide receptor activity | Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein. |
| glucagon family peptide binding | |
| type 1 neuromedin U receptor binding | |
| type 2 neuromedin U receptor binding | |
| L-serine-phosphatidylethanolamine phosphatidyltransferase activity | |
| L-serine-phosphatidylcholine phosphatidyltransferase activity | |
| phosphatidylcholine transporter activity | Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. |
| sphingomyelin transfer activity | |
| tryptophan 2,3-dioxygenase activity | Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine. |
| store-operated calcium channel activity | A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. |
| inositol 1,4,5 trisphosphate binding | Interacting selectively and non-covalently with inositol 1,4,5 trisphosphate. |
| 4-trimethylammoniobutyraldehyde dehydrogenase activity | Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate. |
| C-X3-C chemokine receptor activity | Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif. |
| CX3C chemokine receptor binding | |
| ribose-5-phosphate isomerase activity | Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate. |
| iron ion transmembrane transporter activity | Catalysis of the transfer of iron (Fe) ions from one side of a membrane to the other. |
| manganese ion transmembrane transporter activity | Catalysis of the transfer of manganese (Mn) ions from one side of a membrane to the other. |
| transition metal ion transmembrane transporter activity | Catalysis of the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. |
| metal cation:proton antiporter activity | |
| chromium ion transmembrane transporter activity | |
| cadmium ion transmembrane transporter activity | Catalysis of the transfer of cadmium (Cd) ions from one side of a membrane to the other. |
| cobalt ion transmembrane transporter activity | Catalysis of the transfer of cobalt (Co) ions from one side of a membrane to the other. |
| ferrous iron transmembrane transporter activity | Catalysis of the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. |
| lead ion transmembrane transporter activity | Catalysis of the transfer of lead (Pb) ions from one side of a membrane to the other. |
| nickel cation transmembrane transporter activity | Catalysis of the transfer of nickel (Ni) cations from one side of a membrane to the other. |
| vanadium ion transmembrane transporter activity | |
| inorganic cation transmembrane transporter activity | Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. |
| fatty acid synthase activity | Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. |
| [acyl-carrier-protein] S-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]. |
| protein farnesyltransferase activity | Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate. |
| protein geranylgeranyltransferase activity | Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. |
| deoxyhypusine synthase activity | Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+. |
| betaine-aldehyde dehydrogenase (NAD+) activity | |
| inositol-1,4-bisphosphate 1-phosphatase activity | Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate. |
| inositol-1,3,4-trisphosphate 1-phosphatase activity | Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate. |
| choline-phosphate cytidylyltransferase activity | Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline. |
| aminoacyl-tRNA editing activity | The hydrolysis of an incorrectly aminoacylated tRNA. |
| Ser-tRNA(Ala) hydrolase activity | |
| alanine-tRNA ligase activity | Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). |
| cysteine-tRNA ligase activity | Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). |
| serine-tRNA ligase activity | Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). |
| selenocysteine-tRNA ligase activity | |
| chromatin insulator sequence binding | Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription. |
| RNA polymerase I transcription regulatory region sequence-specific DNA binding | |
| very-long-chain fatty acyl-CoA dehydrogenase activity | |
| vascular endothelial growth factor receptor 3 binding | Interacting selectively and non-covalently with vascular endothelial growth factor receptor 3. |
| aspartic endopeptidase activity, intramembrane cleaving | Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane. |
| deSUMOylase activity | |
| adenosine 5'-monophosphoramidase activity | |
| adenylylsulfate-ammonia adenylyltransferase activity | |
| adenylylsulfatase activity | |
| flavonol 3-sulfotransferase activity | Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H(+) + quercetin 3-sulfate. |
| thyroxine 5'-deiodinase activity | |
| nucleoside phosphotransferase activity | Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate. |
| 5-formyltetrahydrofolate cyclo-ligase activity | |
| GMP synthase activity | Catalysis of the reaction: ATP + xanthosine 5'-phosphate + NH3 = AMP + diphosphate + GMP. |
| GMP synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. |
| DNA ligase (ATP) activity | Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). |
| ketohexokinase activity | Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate. |
| histamine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+). |
| oxygen-dependent protoporphyrinogen oxidase activity | Catalysis of the reaction: 3 O(2) + protoporphyrinogen IX = 3 H(2)O(2) + protoporphyrin IX. |
| pancreatic polypeptide receptor activity | Combining with pancreatic polypeptide PP to initiate a change in cell activity. |
| amidinotransferase activity | Catalysis of the reversible transfer of an amidino group to an acceptor. |
| glycine amidinotransferase activity | Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate. |
| sulfate transmembrane transporter activity | Catalysis of the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other. |
| peroxisome targeting sequence binding | Interacting selectively and non-covalently with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome. |
| peroxisome matrix targeting signal-1 binding | Interacting selectively and non-covalently with a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L. |
| peroxisome membrane targeting sequence binding | Interacting selectively and non-covalently with a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane. |
| bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity | Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H(2)O = 2 ADP + 2 H(+). |
| laminin receptor activity | Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity. |
| poly(A) RNA polymerase activity | |
| MAP kinase phosphatase activity | Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate. |
| galactokinase activity | Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+). |
| thiopurine S-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. |
| G protein-coupled UTP receptor activity | |
| arachidonate 14,15-epoxygenase activity | |
| arachidonate 11,12-epoxygenase activity | |
| linoleic acid epoxygenase activity | Catalysis of an NADPH- and oxygen-dependent reaction that converts linoleic acid to a cis-epoxyoctadecenoic acid. |
| N-acylglucosamine 2-epimerase activity | Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine. |
| long-chain-alcohol oxidase activity | Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O. |
| long-chain fatty aldehyde dehydrogenase (NAD+) activity | |
| medium-chain fatty aldehyde dehydrogenase (NAD+) activity | |
| succinate-semialdehyde dehydrogenase (NAD+) activity | Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+. |
| peptidyl-dipeptidase inhibitor activity | Stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain. |
| N-sulfoglucosamine sulfohydrolase activity | Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate. |
| alpha-2B adrenergic receptor binding | Interacting selectively and non-covalently with an alpha-2B adrenergic receptor. |
| volume-sensitive chloride channel activity | Catalysis of the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell. |
| L-DOPA receptor activity | Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine. |
| G-quadruplex RNA binding | Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad. |
| DNA hairpin binding | Interacting selectively and non-covalently with DNA containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences. |
| AF-2 domain binding | Interacting selectively and non-covalently with the AF-2 domain of a protein, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation. |
| phosphogluconate dehydrogenase (decarboxylating) activity | Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. |
| LRR domain binding | Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein. |
| Rho GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding. |
| RNA endonuclease activity, producing 3'-phosphomonoesters | |
| spermine synthase activity | Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine. |
| neurotrophin TRKB receptor binding | Interacting selectively and non-covalently with the neurotrophin TRKB receptor. |
| neurotrophin TRKC receptor binding | |
| N-acetylglucosamine deacetylase activity | |
| trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity | Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol. |
| MH1 domain binding | Interacting selectively and non-covalently with the MH1 (MAD homology 1) domain of a protein. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors. |
| biliberdin reductase (NAD+) activity | |
| citrate transmembrane transporter activity | Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. |
| tricarboxylic acid transmembrane transporter activity | Catalysis of the transfer of tricarboxylic acids from one side of the membrane to the other. Tricarboxylic acid are organic acids with three COOH groups. |
| citrate secondary active transmembrane transporter activity | |
| calcium/calmodulin-dependent protein kinase activity | |
| NADH pyrophosphatase activity | Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+. |
| ATP citrate synthase activity | Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA. |
| diphosphomevalonate decarboxylase activity | Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate. |
| CAAX-protein geranylgeranyltransferase activity | Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. |
| myo-inositol transmembrane transporter activity | |
| N-acyltransferase activity | Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. |
| succinate transmembrane transporter activity | Catalysis of the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of the membrane to the other. |
| MIT domain binding | Interacting selectively and non-covalently with the MIT domain of a protein. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking. |
| single-stranded DNA 3'-5' DNA exonuclease activity | |
| four-way junction helicase activity | Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions. |
| forked DNA-dependent helicase activity | |
| telomeric G-quadruplex DNA binding | |
| 8-hydroxy-2'-deoxyguanosine DNA binding | |
| arginine-tRNA ligase activity | Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). |
| monoamine:proton antiporter activity | |
| brain-derived neurotrophic factor binding | Interacting selectively and non-covalently with brain-derived neurotrophic factor. |
| ankyrin repeat binding | Interacting selectively and non-covalently with an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure. |
| single base insertion or deletion binding | Interacting selectively and non-covalently with double-stranded DNA containing a single base insertion or deletion. |
| voltage-gated calcium channel activity involved in cardiac muscle cell action potential | Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated calcium channel activity involved in bundle of His cell action potential | |
| galactolipase activity | Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates. |
| tyrosine-tRNA ligase activity | Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+). |
| histone H2BS36 kinase activity | |
| calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity | |
| calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity | |
| PH domain binding | Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton. |
| DH domain binding | Interacting selectively and non-covalently with a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket. |
| alpha-N-acetylglucosaminidase activity | Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. |
| hydroxymethylglutaryl-CoA synthase activity | Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+). |
| glutamate 5-kinase activity | Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+). |
| glutamate-5-semialdehyde dehydrogenase activity | Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH. |
| sodium:potassium:chloride symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in). |
| chloride:monoatomic cation symporter activity | |
| metal ion transmembrane transporter activity | Catalysis of the transfer of metal ions from one side of a membrane to the other. |
| phospholipid transfer activity | |
| diacylglyceride transfer activity | |
| phosphatidylglycerol transfer activity | |
| cerebroside transfer activity | |
| phosphatidylethanolamine transfer activity | |
| endoribonuclease inhibitor activity | Stops, prevents or reduces the activity of an endoribonuclease, any enzyme that catalyzes the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. |
| K48-linked polyubiquitin modification-dependent protein binding | |
| thyroxine 5-deiodinase activity | |
| transforming growth factor beta receptor binding | Interacting selectively and non-covalently with the transforming growth factor beta receptor. |
| triglyceride transfer activity | |
| ceramide 1-phosphate transfer activity | |
| double-stranded RNA adenosine deaminase activity | Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule. |
| nuclear progesterone receptor binding | |
| histone H3R8 methyltransferase activity | |
| U4 snRNA binding | Interacting selectively and non-covalently with the U4 small nuclear RNA (U4 snRNA). |
| U4atac snRNA binding | |
| box C/D sno(s)RNA binding | |
| succinyl-CoA:3-oxo-acid CoA-transferase activity | |
| secondary active sulfate transmembrane transporter activity | Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. |
| oxaloacetate transmembrane transporter activity | |
| malate transmembrane transporter activity | Catalysis of the transfer of malate from one side of the membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. |
| phosphate ion uniporter activity | |
| death receptor binding | Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD). |
| methionine-tRNA ligase activity | Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). |
| beta-aspartyl-peptidase activity | Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide. |
| 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity | |
| tRNA methyltransferase activator activity | |
| neuroligin family protein binding | Interacting selectively and non-covalently with a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation. |
| Toll-like receptor 2 binding | Interacting selectively and non-covalently with a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response. |
| olfactory receptor binding | Interacting selectively and non-covalently with an olfactory receptor. |
| bitter taste receptor activity | Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste. |
| taste receptor activity | Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. |
| triose-phosphate isomerase activity | Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate. |
| methylglyoxal synthase activity | |
| phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate. |
| inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity | |
| inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity | Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate. |
| phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | Catalysis of the reaction: phosphatidylinositol-3,4-bisphosphate + H2O = phosphatidylinositol-4-phosphate + phosphate. |
| phosphatidylinositol phosphate phosphatase activity | Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate. |
| interleukin-2 receptor binding | Interacting selectively and non-covalently with the interleukin-2 receptor. |
| monoatomic cation transmembrane transporter activity | |
| endoplasmic reticulum signal peptide binding | Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum. |
| C-X-C motif chemokine 12 receptor activity | |
| NEDD8 transferase activity | Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages. |
| ubiquitin-protein transferase activator activity | Increases the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein. |
| transition metal ion binding | Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. |
| myosin-light-chain-phosphatase activity | Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate. |
| thyrotropin-releasing hormone receptor binding | Interacting selectively and non-covalently with a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary. |
| U6 snRNA 3'-end binding | Interacting selectively and non-covalently with the 3' end of the U6 small nuclear RNA (U6 snRNA). |
| histone pre-mRNA DCP binding | Interacting selectively and non-covalently with the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing. |
| U7 snRNA binding | Interacting selectively and non-covalently with the U7 small nuclear RNA (U7 snRNA). |
| aminoacyl-tRNA hydrolase activity | Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. |
| NEDD8 ligase activity | |
| Rho GDP-dissociation inhibitor binding | Interacting selectively and non-covalently with a Rho GDP-dissociation inhibitor protein. |
| D2 dopamine receptor binding | Interacting selectively and non-covalently with a D2 dopamine receptor. |
| small protein activating enzyme binding | Interacting selectively and non-covalently with a small protein activating enzyme, such as ubiquitin-activating enzyme. |
| SUMO conjugating enzyme activity | Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y -> Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue. |
| C5-methylcytidine-containing RNA reader activity | |
| cell adhesive protein binding involved in AV node cell-bundle of His cell communication | |
| SUMO polymer binding | Interacting selectively and non-covalently with a polymer of the small ubiquitin-like protein SUMO. |
| alkane 1-monooxygenase activity | Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O. |
| leukotriene-B4 20-monooxygenase activity | Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O. |
| arachidonate omega-hydroxylase activity | |
| alpha-tocopherol omega-hydroxylase activity | Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O . |
| 20-hydroxy-leukotriene B4 omega oxidase activity | |
| 20-aldehyde-leukotriene B4 20-monooxygenase activity | |
| L-phosphoserine phosphatase activity | |
| pH-gated monoatomic ion channel activity | |
| beta-1 adrenergic receptor binding | Interacting selectively and non-covalently with a beta-1 adrenergic receptor. |
| P2Y1 nucleotide receptor binding | Interacting selectively and non-covalently with a P2Y1 nucleotide receptor. |
| N-retinylidene-phosphatidylethanolamine flippase activity | |
| UDP-galactose transmembrane transporter activity | Catalysis of the transfer of a UDP-galactose from one side of the membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate. |
| CMP-N-acetylneuraminate transmembrane transporter activity | Catalysis of the transfer of a CMP-N-acetylneuraminate from one side of the membrane to the other. |
| CXCR1 chemokine receptor binding | |
| lipoprotein particle receptor binding | Interacting selectively and non-covalently with a lipoprotein particle receptor. |
| DNA-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of DNA. |
| histone H2AXS139 kinase activity | |
| arginase activity | Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea. |
| oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity | Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. |
| death domain binding | Interacting selectively and non-covalently with a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB. |
| glycosylphosphatidylinositol phospholipase D activity | Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol. |
| JUN kinase kinase kinase activity | Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs). |
| 11-beta-hydroxysteroid dehydrogenase (NAD+) activity | |
| 4-aminobutyrate:2-oxoglutarate transaminase activity | |
| succinate-semialdehyde dehydrogenase binding | Interacting selectively and non-covalently with succinate-semialdehyde dehydrogenase. |
| iron ion transmembrane transporter inhibitor activity | |
| monoatomic anion channel activity | |
| broad specificity neutral L-amino acid:basic L-amino acid antiporter activity | |
| orexigenic neuropeptide QRFP receptor binding | Interacting selectively and non-covalently with an orexigenic neuropeptide QRFP receptor. |
| DEAD/H-box RNA helicase binding | Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase. |
| nuclear mineralocorticoid receptor binding | |
| reelin receptor activity | Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| phosphate:proton symporter activity | |
| ErbB-2 class receptor binding | Interacting selectively and non-covalently with the protein-tyrosine kinase receptor Neu/ErbB-2/HER2. |
| RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding | Interacting selectively and non-covalently with an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within. |
| L-iditol 2-dehydrogenase (NAD+) activity | |
| poly(C) RNA binding | Interacting selectively and non-covalently with a sequence of cytosine residues in an RNA molecule. |
| piRNA binding | Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. |
| (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide. |
| interleukin-9 receptor activity | Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| interleukin-33 receptor activity | Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| L-tryptophan transmembrane transporter activity | |
| trimethylamine monooxygenase activity | Catalysis of the reaction: N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O. |
| RNA exonuclease activity | |
| P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration | |
| heteroduplex DNA loop binding | Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration. |
| inositol phosphate phosphatase activity | Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate. |
| N-acylsphingosine amidohydrolase activity | |
| N-(long-chain-acyl)ethanolamine deacylase activity | |
| methylammonium transmembrane transporter activity | |
| leak channel activity | Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state. |
| dihydroorotate dehydrogenase (quinone) activity | |
| oxoglutarate dehydrogenase (succinyl-transferring) activity | Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2. |
| methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity | |
| nickel cation binding | Interacting selectively and non-covalently with nickel (Ni) cations. |
| cholesterol 26-hydroxylase activity | Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol. |
| cholestanetetraol 26-dehydrogenase activity | |
| 3-hydroxybutyrate dehydrogenase activity | Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH. |
| growth hormone-releasing hormone receptor activity | Combining with growth hormone-releasing hormone to initiate a change in cell activity. |
| guanylate cyclase activator activity | Increases the activity of guanylate cyclase. |
| cupric ion binding | Interacting selectively and non-covalently with cupric ion, copper(2+). |
| inward rectifier potassium channel inhibitor activity | Stops, prevents, or reduces the activity of an inwardly rectifying potassium channel. |
| unmethylated CpG binding | Interacting selectively and non-covalently with unmethylated CpG motifs. Unmethylated CpG dinucleotides are often associated with gene promoters. |
| protein-cysteine methyltransferase activity | |
| histone H3K4 trimethyltransferase activity | |
| transforming growth factor beta receptor activity, type III | Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors. |
| linoleic acid binding | Interacting selectively and non-covalently with linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid. |
| mevalonate kinase activity | Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+). |
| parathyroid hormone receptor activity | Combining with parathyroid hormone to initiate a change in cell activity. |
| ABC-type peptide antigen transporter activity | |
| K6-linked polyubiquitin modification-dependent protein binding | |
| 1,4-alpha-glucan branching enzyme activity | Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain. |
| Ac-Asp-Glu binding | |
| superoxide dismutase copper chaperone activity | A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity. |
| P-type monovalent copper transporter activity | |
| lactoylglutathione lyase activity | Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. |
| steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative. |
| androsterone dehydrogenase (B-specific) activity | Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+. |
| ligand-gated sodium channel activity | Catalysis of the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
| protein tyrosine/threonine phosphatase activity | Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| tetrahydrofolylpolyglutamate synthase activity | Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). |
| 3-dehydrosphinganine reductase activity | Catalysis of the reaction: NADP(+) + sphinganine = 3-dehydrosphinganine + H(+) + NADPH. |
| alcohol sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate. |
| bile-salt sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate. |
| DNA strand exchange activity | |
| siRNA binding | Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. |
| adrenergic receptor binding | Interacting selectively and non-covalently with an adrenergic receptor. |
| ethanolaminephosphotransferase activity | Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine. |
| 25-hydroxycholecalciferol-24-hydroxylase activity | Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol. |
| 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity | Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol). |
| 25-hydroxycholecalciferol-23-hydroxylase activity | |
| regulatory region RNA binding | |
| 3'-5' DNA/RNA helicase activity | |
| triplex DNA binding | |
| single-stranded 3'-5' DNA helicase activity | |
| NADH binding | Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. |
| interleukin-10 receptor activity | Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| protein tyrosine kinase collagen receptor activity | Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
| long-chain-3-hydroxyacyl-CoA dehydrogenase activity | Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
| very long-chain fatty acid omega-hydroxylase activity | |
| pseudouridine 5'-phosphatase activity | |
| CoA-ligase activity | Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA. |
| benzoate-CoA ligase activity | |
| medium-chain fatty acid-CoA ligase activity | |
| mRNA (cytidine-5-)-methyltransferase activity | |
| myosin phosphatase regulator activity | Modulation of the activity of the enzyme myosin phosphatase. |
| beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R. |
| alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors. |
| L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor | |
| protein N-acetyltransferase activity | |
| histone H3K18 acetyltransferase activity | |
| histone H3K27 acetyltransferase activity | |
| protein propionyltransferase activity | |
| histone lactyltransferase (CoA-dependent) activity | |
| peptide butyryltransferase activity | |
| histone crotonyltransferase activity | |
| histone H3K122 acetyltransferase activity | |
| alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R. |
| beta-galactoside (CMP) alpha-2,3-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R. |
| N-acetyllactosaminide alpha-2,3-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein. |
| beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase | |
| P-type magnesium transporter activity | |
| sterol binding | Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. |
| C-8 sterol isomerase activity | Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols. |
| large conductance calcium-activated potassium channel activity | Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. |
| sphingomyelin phosphodiesterase activator activity | Increases the activity of the enzyme sphingomyelin phosphodiesterase. |
| proton-dependent oligopeptide secondary active transmembrane transporter activity | Catalysis of the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement. |
| dihydropyrimidine dehydrogenase (NADP+) activity | Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+. |
| protoheme IX farnesyltransferase activity | Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme o + diphosphate. |
| receptor signaling protein tyrosine kinase inhibitor activity | Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase. |
| bile acid:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). |
| phosphatidylinositol 3-kinase regulatory subunit binding | Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location. |
| ribonuclease E activity | Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. |
| endoplasmic reticulum-autophagosome adaptor activity | |
| mitochondrion autophagosome adaptor activity | |
| extracellularly glutamate-gated ion channel activity | |
| adenylate cyclase inhibiting G protein-coupled glutamate receptor activity | |
| dephospho-CoA kinase activity | Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+). |
| pantetheine-phosphate adenylyltransferase activity | Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate. |
| adenosine receptor binding | Interacting selectively and non-covalently with an adenosine receptor. |
| MAP kinase serine/threonine phosphatase activity | |
| 1,4-alpha-oligoglucan phosphorylase activity | |
| death effector domain binding | Interacting selectively and non-covalently with a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD). |
| fumarate transmembrane transporter activity | |
| alpha-ketoglutarate transmembrane transporter activity | |
| low-affinity sodium:dicarboxylate symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. |
| sodium:dicarboxylate symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). |
| methanethiol oxidase activity | |
| hydrolase activity, hydrolyzing O-glycosyl compounds | Catalysis of the hydrolysis of any O-glycosyl bond. |
| endochitinase activity | Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain. |
| cGMP-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP. |
| MHC class Ib protein binding, via antigen binding groove | Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules via the antigen binding groove. |
| G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential | |
| prostaglandin D receptor activity | Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity. |
| Krueppel-associated box domain binding | Interacting selectively and non-covalently with a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors. |
| glycolipid transfer activity | |
| NAD(P)+ transhydrogenase (Si-specific) activity | |
| FHA domain binding | Interacting selectively and non-covalently with a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich. |
| glycosylation-dependent protein binding | |
| magnesium ion transmembrane transporter activity | Catalysis of the transfer of magnesium (Mg) ions from one side of a membrane to the other. |
| K63-linked polyubiquitin modification-dependent protein binding | |
| pH-gated chloride channel activity | |
| HLH domain binding | Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. |
| G/U mismatch-specific uracil-DNA glycosylase activity | |
| inositol-1,3,4,5-tetrakisphosphate 6-kinase activity | |
| inositol-3,4,5,6-tetrakisphosphate 1-kinase activity | |
| inositol-1,3,4-trisphosphate 6-kinase activity | Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+). |
| inositol-1,3,4-trisphosphate 5-kinase activity | Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+). |
| lipid kinase activity | Catalysis of the phosphorylation of a simple or complex lipid. |
| POZ domain binding | Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors. |
| histone H3T45 kinase activity | |
| GDP-4-dehydro-D-rhamnose reductase activity | Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed. |
| GDP-mannose 3,5-epimerase activity | |
| GDP-L-fucose synthase activity | Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+. |
| smoothened binding | Interacting selectively and non-covalently with the smoothened (smo) protein, which interacts with patched to transmit hedgehog signals. |
| 2-oxoglutarate-dependent dioxygenase activity | |
| broad specificity oxidative DNA demethylase activity | |
| tRNA demethylase activity | |
| Glc3Man9GlcNAc2 oligosaccharide glucosidase activity | |
| glucosidase activity | Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. |
| methylglutaconyl-CoA hydratase activity | Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O. |
| isopentenyl-diphosphate delta-isomerase activity | Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate. |
| glycine N-choloyltransferase activity | Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate. |
| very long-chain fatty acyl-CoA hydrolase activity | |
| interleukin-18 receptor binding | Interacting selectively and non-covalently with the interleukin-18 receptor. |
| dihydropyrimidinase activity | Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate. |
| histone H4K20 trimethyltransferase activity | |
| histone H4K20me3 reader activity | |
| 3'-flap-structured DNA binding | |
| translation release factor activity, codon nonspecific | A translation release factor that is not specific to particular codons; binds to guanine nucleotides. |
| RIG-I binding | |
| guanidinoacetate N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H(+). |
| UDP-glucose 4-epimerase activity | Catalysis of the reaction: UDP-glucose = UDP-galactose. |
| 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity | |
| N-box binding | Interacting selectively and non-covalently with an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses. |
| histone pre-mRNA stem-loop binding | Interacting selectively and non-covalently with a conserved stem-loop structure found in histone pre-mRNAs. |
| voltage-gated sodium channel activity involved in cardiac muscle cell action potential | Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated sodium channel activity involved in AV node cell action potential | Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated sodium channel activity involved in bundle of His cell action potential | Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated sodium channel activity involved in Purkinje myocyte action potential | Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated sodium channel activity involved in SA node cell action potential | Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| squalene monooxygenase activity | Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+). |
| nucleoside transmembrane transporter activity | Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. |
| guanine transmembrane transporter activity | |
| uracil transmembrane transporter activity | |
| inositol 1,4,5-trisphosphate-gated calcium channel activity | |
| interleukin-11 receptor activity | Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| inositol-polyphosphate 5-phosphatase activity | Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. |
| glucan 1,3-alpha-glucosidase activity | Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans. |
| tetracycline transmembrane transporter activity | |
| glycine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine. |
| group III metabotropic glutamate receptor activity | A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity. |
| adenylate cyclase inhibitor activity | Decreases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate. |
| thiomorpholine-carboxylate dehydrogenase activity | Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate. |
| 2-alkenal reductase (NADPH) activity | |
| 13-lipoxin reductase activity | |
| 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity | |
| leukotriene B4 12-hydroxy dehydrogenase activity | |
| HLA-C specific inhibitory MHC class I receptor activity | |
| U6atac snRNA binding | Interacting selectively and non-covalently with the U6atac small nuclear RNA (U6atac snRNA). |
| leucine-tRNA ligase activity | Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu). |
| monoatomic anion:monoatomic cation symporter activity | |
| monoatomic cation:bicarbonate symporter activity | |
| ATP:ADP adenylyltransferase activity | |
| lysine-tRNA ligase activity | Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). |
| G protein-coupled UDP receptor activity | |
| pyruvate dehydrogenase (acetyl-transferring) kinase activity | Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate. |
| cholesterol-5,6-oxide hydrolase activity | |
| phosphomevalonate kinase activity | Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H(+). |
| UFM1-modified protein reader activity | |
| nicotinate-nucleotide diphosphorylase (carboxylating) activity | Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate. |
| neuregulin receptor activity | |
| promoter-enhancer loop anchoring activity | |
| axon guidance receptor activity | Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance. |
| Delta24(24-1) sterol reductase activity | Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH. |
| oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. |
| Delta24-sterol reductase activity | Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol. |
| mannan binding | Interacting selectively and non-covalently with mannan. |
| gluconolactonase activity | Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate. |
| leukotriene receptor activity | Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine. |
| 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity | |
| myosin light chain kinase activity | Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate. |
| GMP binding | Interacting selectively and non-covalently with GMP, guanosine monophosphate. |
| C-4 methylsterol oxidase activity | Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O. |
| syntaxin-3 binding | Interacting selectively and non-covalently with the SNAP receptor syntaxin-3. |
| histone H3K27 methyltransferase activity | |
| protein serine pyrophosphorylase activity | |
| intracellularly cyclic nucleotide-activated monoatomic cation channel activity | |
| glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP. |
| heparan sulfate N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate. |
| N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity | Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP. |
| pH-gated sodium channel activity | |
| all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity | Catalysis of the reaction: H(2)O + all-trans-retinyl palmitate = 11-cis-retinol + H(+) + palmitate. |
| all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity | Catalysis of the reaction: H(2)O + all-trans-retinyl ester = 11-cis-retinol + fatty acid. |
| deoxyribodipyrimidine photo-lyase activity | Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light. |
| DNA (6-4) photolyase activity | Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA. |
| blue light photoreceptor activity | The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation. |
| acetylcholine:proton antiporter activity | |
| complement component C3a receptor activity | Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| porin activity | Catalysis of the transfer of substances, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. |
| aralkylamine N-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine. |
| brain-derived neurotrophic factor receptor activity | |
| prostaglandin-I synthase activity | Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2). |
| anti-Mullerian hormone receptor activity | Combining with anti-Mullerian hormone to initiate a change in cell activity. |
| 2,4-dienoyl-CoA reductase (NADPH) activity | Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+. |
| alpha-mannosidase activity | Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. |
| kynureninase activity | Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine. |
| P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration | |
| ceramide glucosyltransferase activity | Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine. |
| thiosulfate-cyanide sulfurtransferase activity | |
| kynurenine-oxoglutarate transaminase activity | Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. |
| cysteine-S-conjugate beta-lyase activity | Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate. |
| hydroxyacylglutathione hydrolase activity | Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. |
| phosphoenolpyruvate carboxykinase activity | Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products. |
| UTP:glucose-1-phosphate uridylyltransferase activity | Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose. |
| cysteine dioxygenase activity | Catalysis of the reaction: L-cysteine + O(2) = 3-sulfino-L-alanine + H(+). |
| N-acylsphingosine galactosyltransferase activity | |
| organic acid:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in). |
| monocarboxylate:sodium symporter activity | |
| UDP-N-acetylglucosamine transmembrane transporter activity | Catalysis of the transfer of a UDP-N-acetylglucosamine from one side of the membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. |
| voltage-gated channel activity | Catalysis of the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| NAD+-protein-cysteine ADP-ribosyltransferase activity | |
| alpha-1,2-mannosyltransferase activity | Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage. |
| GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity | Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. |
| sodium:bicarbonate symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in). |
| sodium ion transmembrane transporter activity | Catalysis of the transfer of sodium ions (Na+) from one side of a membrane to the other. |
| sodium,bicarbonate:chloride antiporter activity | |
| CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity | Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+). |
| procollagen-proline 3-dioxygenase activity | Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2. |
| glycerone kinase activity | Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+). |
| triokinase activity | Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H(+). |
| aminophospholipid flippase activity | |
| tRNA pseudouridine synthase activity | |
| 2-acylglycerol O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol. |
| UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose. |
| phosphatidylinositol phosphate binding | Interacting selectively and non-covalently with phosphatidylinositol phosphate. |
| amino acid:proton symporter activity | |
| proline:proton symporter activity | |
| SUMO-ubiquitin ligase activity | |
| tRNA-queuosine(34) beta-mannosyltransferase activity | |
| histone H4 methyltransferase activity | |
| all-trans retinol 3,4-desaturase activity | |
| all-trans retinal 3,4-desaturase activity | |
| all-trans retinoic acid 3,4-desaturase activity | |
| 11-cis-retinal 3,4-desaturase activity | |
| acid-thiol ligase activity | Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| malonyl-CoA synthetase activity | Catalysis of the reaction: malonate + ATP + coenzyme A = malonyl-CoA + AMP + diphosphate. |
| calcium-activated cation channel activity | |
| glycerol-3-phosphate O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate. |
| GPI-mannose ethanolamine phosphate phosphodiesterase activity | |
| thiamine pyrophosphate transmembrane transporter activity | |
| very-long-chain 3-oxoacyl-CoA reductase activity | |
| acylglycerol kinase activity | Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate. |
| histone H3K36 dimethyltransferase activity | |
| single-strand selective uracil DNA N-glycosylase activity | Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA. |
| long-chain-alcohol O-fatty-acyltransferase activity | Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA. |
| initiator methionyl aminopeptidase activity | |
| cysteine-type aminopeptidase activity | |
| sucrose:proton symporter activity | |
| (d)CMP kinase activity | |
| CP2 mannose-ethanolamine phosphotransferase activity | Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2. |
| 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity | |
| dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity | |
| glutamate-tRNA(Gln) ligase activity | Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP. |
| intracellular sodium-activated potassium channel activity | |
| UDP-glucose transmembrane transporter activity | |
| GTP-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of GTP. |
| peroxidase inhibitor activity | Interacts with, and stops, prevents or reduces the activity of a peroxidase. |
| tubulin N-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine. |
| glycoprotein endo-alpha-1,2-mannosidase activity | Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane. |
| ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity | Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA. |
| glycine N-acyltransferase activity | Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine. |
| all-trans-decaprenyl-diphosphate synthase activity | |
| G protein-coupled glycine receptor activity | |
| RNA methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. |
| small RNA 2'-O-methyltransferase activity | |
| RNA uridylyltransferase activity | Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1). |
| 16-hydroxypalmitate dehydrogenase activity | |
| medium-chain fatty acid omega-hydroxylase activity | |
| 5-aminolevulinic acid transmembrane transporter activity | |
| nitrate reductase activity | Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor. |
| molybdenum ion binding | Interacting selectively and non-covalently with molybdenum (Mo) ions. |
| histone H2B C-terminal K residue ubiquitin ligase activity | |
| histone H2A deubiquitinase activity | |
| N-terminal protein N-methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser. |
| uridylyltransferase activity | Catalysis of the transfer of an uridylyl group to an acceptor. |
| guanyl ribonucleotide binding | Interacting selectively and non-covalently with a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. |
| palmitoyltransferase activity | Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. |
| guanylyltransferase activity | Catalysis of the transfer of a guanylyl group to an acceptor. |
| 2-acylglycerol-3-phosphate O-acyltransferase activity | |
| 1-alkenylglycerophosphoethanolamine O-acyltransferase activity | Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA. |
| 1-alkylglycerophosphocholine O-acetyltransferase activity | Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA. |
| lysophospholipid acyltransferase activity | Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid. |
| 1-acylglycerophosphoethanolamine O-acyltransferase activity | |
| 1-acylglycerophosphoserine O-acyltransferase activity | |
| ferric-chelate reductase (NADPH) activity | Catalysis of the reaction: 2 Fe3+ + NADPH = 2 Fe2+ + H+ + NADP+ . |
| tRNA-queuosine(34) galactosyltransferase activity | |
| heparan-alpha-glucosaminide N-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide. |
| thromboxane A2 receptor binding | Interacting selectively and non-covalently with a thromboxane A2 receptor. |
| tubulin-tyrosine carboxypeptidase | |
| retinol O-fatty-acyltransferase activity | Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester. |
| histone H3K36 trimethyltransferase activity | |
| glutamic-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad. |
| NAD+ synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate. |
| acylglycerone-phosphate reductase (NADP+) activity | |
| glycine N-benzoyltransferase activity | Catalysis of the reaction: benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+). |
| rRNA (guanosine-2'-O-)-methyltransferase activity | |
| N-acylphosphatidylethanolamine-specific phospholipase D activity | Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE). |
| calcium:monoatomic cation antiporter activity | |
| calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell. |
| cohesin loader activity | |
| ATP:phosphate antiporter activity | |
| oligoribonucleotidase activity | |
| acetylgalactosaminyltransferase activity | Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide. |
| molybdate ion transmembrane transporter activity | Catalysis of the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid. |
| volume-sensitive anion channel activity | Catalysis of the transmembrane transfer of an anion by a volume-sensitive channel. An anion is a negatively charged ion. A volume-sensitive channel is a channel that responds to changes in the volume of a cell. |
| polyamine:proton antiporter activity | |
| ADP:phosphate antiporter activity | |
| all-trans-retinol 13,14-reductase activity | Catalysis of the reaction: all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH(2). Note that this reaction has only been observed to occur in the opposite direction. |
| deUFMylase activity | |
| 3-hydroxyisobutyryl-CoA hydrolase activity | Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate. |
| zinc:proton antiporter activity | |
| histone H3R2 demethylase activity | |
| histone H4R3 demethylase activity | |
| rRNA primary transcript binding | Interacting selectively and non-covalently with an unprocessed ribosomal RNA transcript. |
| fatty acid transmembrane transporter activity | |
| tRNA (cytidine) methyltransferase activity | |
| tRNA (cytidine-3-)-methyltransferase activity | |
| tRNA-dihydrouridine16 synthase activity | |
| tRNA-dihydrouridine17 synthase activity | |
| oxaloacetate tautomerase activity | |
| acetylpyruvate hydrolase activity | Catalysis of the reaction: acetylpyruvate + H(2)O = acetate + H(+) + pyruvate. |
| fumarylpyruvate hydrolase activity | Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+. |
| zinc ion sensor activity | |
| mRNA N6-methyladenosine dioxygenase activity | |
| palmitoleyl hydrolase activity | |
| biotin transmembrane transporter activity | |
| glucose-1,6-bisphosphate synthase activity | Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate + H(+). |
| tRNA (guanosine(9)-N1)-methyltransferase activity | |
| iodotyrosine deiodinase activity | |
| aspartate-tRNA ligase activity | Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). |
| aspartate-tRNA(Asn) ligase activity | Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP. |
| 5'-3' DNA exonuclease activity | |
| sugar transmembrane transporter activity | Catalysis of the transfer of a sugar from one side of the membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. |
| lipase activator activity | Increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. |
| polyamine oxidase activity | Catalysis of the oxidative degradation or interconversion of polyamines. |
| NAD+ nucleosidase activity | Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose. |
| protein-arginine deiminase activity | Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3. |
| chloride-activated potassium channel activity | |
| UDP-glucosyltransferase activity | Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule. |
| glycerophosphocholine cholinephosphodiesterase activity | Catalysis of the reaction: sn-glycero-3-phosphocholine + H(2)O = choline phosphate + glycerol + H(+). |
| glucuronate-2-sulfatase activity | |
| thiol S-methyltransferase activity | |
| virus coreceptor activity | |
| D3 vitamins binding | Interacting selectively and non-covalently with D3 vitamins. |
| nicotinate phosphoribosyltransferase activity | Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate. |
| calcium:manganese antiporter activity | |
| kynurenine-glyoxylate transaminase activity | Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine. |
| beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP. |
| glyceryl-ether monooxygenase activity | Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine). |
| GDP-D-glucose phosphorylase activity | Catalysis of the reaction: GDP-D-glucose + phosphate = D-glucose-1-P + GDP. |
| mannosyltransferase activity | Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
| uniporter activity | Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species. |
| 8-oxo-dGDP phosphatase activity | Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate. |
| 8-oxo-GDP phosphatase activity | Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate. |
| 8-hydroxy-dADP phosphatase activity | Catalysis of the reaction8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate. |
| histone H2B deubiquitinase activity | |
| ubiquitin-like protein peptidase activity | |
| ISG15-specific peptidase activity | |
| S-adenosyl-L-methionine transmembrane transporter activity | Catalysis of the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. |
| S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity | |
| glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity | Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP. |
| N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity | Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP. |
| phosphatidylinositol deacylase activity | |
| nucleotide-sugar transmembrane transporter activity | Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. |
| tRNA (adenine(9)-N1)-methyltransferase activity | |
| dermatan 4-sulfotransferase activity | |
| chondroitin 4-sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate. |
| asparaginase activity | Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3. |
| RNA 5'-gamma-phosphate methyltransferase activity | |
| fatty acid 2-hydroxylase activity | |
| free fatty acid 2-hydroxylase activity | |
| 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase activity | |
| L-fuconate dehydratase activity | Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H(2)O. |
| diphthine-ammonia ligase activity | Catalysis of the reaction: ATP + diphthine + NH(4)(+) = ADP + diphthamide + H(+) + phosphate. |
| N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity | Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate. |
| heparan sulfate 2-sulfotransferase activity | |
| chondroitin 6-sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate. |
| sweet taste receptor activity | Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste. |
| DNA 5'-adenosine monophosphate hydrolase activity | Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus. |
| polynucleotide 3'-phosphatase activity | Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage. |
| transcription termination site sequence-specific DNA binding | Interacting selectively and non-covalently with a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon. |
| sour taste receptor activity | Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste. |
| tRNA (guanine(10)-N2)-methyltransferase activity | |
| histone H3K9me2/3 reader activity | |
| L-xylulose reductase (NADPH) activity | |
| calmodulin-lysine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine. |
| stem cell factor receptor binding | Interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor. |
| A2A adenosine receptor binding | Interacting selectively and non-covalently with an A2A adenosine receptor. |
| histone ubiquitin ligase activity | |
| prenyltransferase activity | Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). |
| ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity | |
| phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. |
| muscle alpha-actinin binding | Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc. |
| cysteine-type exopeptidase activity | Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| mRNA m(6)A methyltransferase activity | |
| L-threonylcarbamoyladenylate synthase | |
| lithium:proton antiporter activity | |
| guanylate cyclase inhibitor activity | Stops, prevents or reduces the activity of guanylate cyclase. |
| histone H2A acetyltransferase activity | |
| protein N-terminal-serine acetyltransferase activity | |
| acetoacetate-CoA ligase activity | Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H(+). |
| myosin VI light chain binding | Interacting selectively and non-covalently with a light chain of a myosin VI complex. |
| polyspecific organic cation:proton antiporter activity | |
| ceramide phosphoethanolamine synthase activity | |
| sphingomyelin synthase activity | Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin. |
| ceramide cholinephosphotransferase activity | Catalysis of the reaction: CDP-choline + ceramide = CMP + H(+) + sphingomyelin. |
| fatty acid in-chain hydroxylase activity | |
| U6 snRNA (adenine-(43)-N(6))-methyltransferase activity | |
| poly(ADP-ribose) glycohydrolase activity | Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose. |
| alpha-amino-acid esterase activity | |
| cyclic-di-GMP binding | Interacting selectively and non-covalently with cyclic-di-GMP, cyclic dimeric guanosine monophosphate. |
| histone methyltransferase inhibitor activity | |
| histone arginine N-methyltransferase activity | |
| protein-arginine omega-N asymmetric methyltransferase activity | Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues. |
| histone H3R17 methyltransferase activity | |
| histone H3R2 methyltransferase activity | |
| deaminated glutathione amidase activity | |
| (R,S)-4-hydroxy-2-oxoglutarate aldolase activity | |
| folate reductase activity | |
| SAM domain binding | Interacting selectively and non-covalently with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes. |
| acetylcholine receptor inhibitor activity | |
| dolichyldiphosphatase activity | Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate. |
| interleukin-28 receptor binding | Interacting selectively and non-covalently with the interleukin-28 receptor. |
| 5'-3' RNA exonuclease activity | |
| RNA exonuclease activity, producing 5'-phosphomonoesters | |
| single-stranded DNA 5'-3' DNA exonuclease activity | |
| chylomicron binding | Interacting selectively and non-covalently with a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. |
| oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor | |
| S-methyl-5-thioadenosine phosphorylase activity | Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate. |
| guanosine phosphorylase activity | |
| potassium:proton antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in). |
| magnesium:sodium antiporter activity | |
| [acyl-carrier-protein] S-malonyltransferase activity | Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]. |
| glycerate kinase activity | Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H(+). |
| ATP-dependent NAD(P)H-hydrate dehydratase activity | Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H(+) + NADH + phosphate. |
| ethanolamine transmembrane transporter activity | |
| tryptophan 5-monooxygenase activity | Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O. |
| histone H2A ubiquitin ligase activity | |
| hydroxyacid-oxoacid transhydrogenase activity | Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate. |
| oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. |
| histone deacetylase activity, NAD-dependent | |
| tubulin deacetylase activity | Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate. |
| NAD-dependent protein lysine deacetylase activity | |
| histone H4K16 deacetylase activity, NAD-dependent | |
| NAD-dependent protein demyristoylase activity | |
| NAD-dependent protein depalmitoylase activity | |
| peptide-methionine (R)-S-oxide reductase activity | Catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. |
| N-acetyl-L-aspartate-L-glutamate ligase activity | Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate. |
| NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity | |
| DNA secondary structure binding | Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions. |
| isoprenoid diphosphate phosphatase activity | |
| peptidoglycan transmembrane transporter activity | |
| RNA 2'-O-methyltransferase activity | |
| mRNA (nucleoside-2'-O-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine. |
| histone H2AK15 ubiquitin ligase activity | |
| C-methyltransferase activity | Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule. |
| tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent | |
| chondroitin-glucuronate 5-epimerase activity | Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate. |
| vitamin-K-epoxide reductase (warfarin-sensitive) activity | Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol. |
| N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. |
| fucokinase activity | Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H(+). |
| malate synthase activity | |
| (S)-citramalyl-CoA lyase activity | |
| L-glutamate N-acetyltransferase activity | |
| ligand-gated monoatomic anion channel activity | |
| cardiolipin hydrolase activity | Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol) to form phosphatidic acid (PA). |
| alkenylglycerophosphocholine hydrolase activity | Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde. |
| L-methionine transmembrane transporter activity | Catalysis of the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid. |
| L-phenylalanine transmembrane transporter activity | |
| site-specific DNA-methyltransferase (adenine-specific) activity | |
| transposase activity | Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. |
| MHC class Ib protein complex binding | |
| inhibitory MHC class I receptor activity | Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte. |
| (R)-2-hydroxyglutarate dehydrogenase activity | Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. |
| carnosine N-methyltransferase activity | |
| NAD(P)H dehydrogenase (quinone) activity | |
| 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity | Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. |
| peptidyl-proline 3-dioxygenase activity | Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2. |
| tRNA-uridine aminocarboxypropyltransferase activity | |
| polyprenol dehydrogenase activity | |
| dolichal reductase [NAD(P)+] activity | |
| box C/D methylation guide snoRNP complex binding | |
| cysteine-type carboxypeptidase activity | Catalysis of the hydrolysis of C-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| NAD+-protein-lysine ADP-ribosyltransferase activity | |
| 2-aminoadipate transaminase activity | Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate. |
| glycine:2-oxoglutarate aminotransferase activity | |
| methionine-glyoxylate transaminase activity | |
| ether hydrolase activity | Catalysis of the hydrolysis of an ether bond, -O-. |
| D-lysine 5,6-aminomutase activity | |
| iodide channel activity | |
| interferon receptor activity | Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| interleukin-22 receptor activity | Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| histone H3K9 deacetylase activity, hydrolytic mechanism | |
| histone H3K9 deacetylase activity, NAD-dependent | |
| histone H3K18 deacetylase activity, NAD-dependent | |
| histone H3K56 deacetylase activity, NAD-dependent | |
| ubiquitin-protein transferase inhibitor activity | Stops, prevents or reduces the activity of a ubiquitin-protein transferase. |
| 2',3'-cyclic GMP-AMP synthase activity | |
| endodeoxyribonuclease activity, producing 5'-phosphomonoesters | Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. |
| RNA endonuclease activity, producing 5'-phosphomonoesters | |
| high-affinity L-arginine transmembrane transporter activity | |
| high-affinity lysine transmembrane transporter activity | Catalysis of the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. |
| omega-hydroxyceramide transacylase activity | |
| RNA ligase (ATP) activity | Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m). |
| L-aspartate N-acetyltransferase activity | |
| succinyl-CoA hydrolase activity | Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate. |
| lysophospholipid:sodium symporter activity | |
| interleukin-17 receptor activity | Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| xylosyl alpha-1,3-xylosyltransferase activity | |
| nucleic acid transmembrane transporter activity | Catalysis of the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information. |
| formylglycine-generating oxidase activity | |
| K11-linked polyubiquitin modification-dependent protein binding | |
| active borate transmembrane transporter activity | |
| L-asparagine transmembrane transporter activity | Catalysis of the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid. |
| sterol sensor activity | |
| UDP-glucuronate decarboxylase activity | Catalysis of the reaction: H(+) + UDP-alpha-D-glucuronate = CO(2) + UDP-alpha-D-xylose. |
| N-acetylglucosamine 6-O-sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate. |
| alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein. |
| L-glutamate uniporter activity | |
| choline dehydrogenase activity | Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde. |
| extracellular ligand-gated monoatomic ion channel activity | |
| excitatory extracellular ligand-gated monoatomic ion channel activity | |
| interleukin-27 receptor binding | Interacting selectively and non-covalently with the interleukin-27 receptor. |
| plasmalogen synthase activity | |
| FMN adenylyltransferase activity | Catalysis of the reaction: ATP + FMN = diphosphate + FAD. |
| mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity | Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. |
| intracellularly ligand-gated monoatomic ion channel activity | |
| thiosulfate-thiol sulfurtransferase activity | |
| inositol-1,4,5-trisphosphate 6-kinase activity | Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H(+). |
| inositol-1,4,5,6-tetrakisphosphate 3-kinase activity | |
| inositol-1,3,4,6-tetrakisphosphate 5-kinase activity | |
| trace-amine receptor activity | Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals. |
| transmembrane receptor protein tyrosine kinase inhibitor activity | |
| HLA-A specific inhibitory MHC class I receptor activity | Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte. |
| fluoride channel activity | |
| NAADP-sensitive calcium-release channel activity | Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts. |
| intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity | |
| zinc efflux transmembrane transporter activity | |
| 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity | Catalysis of the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other. |
| N-acylneuraminate-9-phosphatase activity | Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate. |
| prostaglandin F synthase activity | |
| ethanolamine-phosphate phospho-lyase activity | Catalysis of the reaction: H(2)O + phosphoethanolamine = acetaldehyde + NH(4)(+) + phosphate. |
| nucleotidase activity | Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. |
| pyrimidine nucleotide binding | Interacting selectively and non-covalently with pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate. |
| MHC protein binding | Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. |
| polyribonucleotide nucleotidyltransferase activity | Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1). |
| ceramide kinase activity | Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate. |
| phosphocholine phosphatase activity | Catalysis of the reaction: choline phosphate + H2O = choline + phosphate. |
| corticotropin hormone receptor binding | Interacting selectively and non-covalently with a corticotropin hormone receptor. |
| type 5 melanocortin receptor binding | Interacting selectively and non-covalently with a type 5 melanocortin receptor. |
| immunoglobulin receptor activity | Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| protein ADP-ribosyltransferase-substrate adaptor activity | |
| histone H4K91 ubiquitin ligase activity | |
| nicotinic acid receptor activity | Combining with nicotinic acid to initiate a change in cell activity. |
| 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding | Interacting selectively and non-covalently with 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. |
| 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding | Interacting selectively and non-covalently with 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. |
| 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding | Interacting selectively and non-covalently with 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. |
| G protein-coupled bile acid receptor activity | |
| aminocarboxymuconate-semialdehyde decarboxylase activity | Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2). |
| peptidoglycan glycosyltransferase activity | Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate. |
| glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity | Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP. |
| pantothenate kinase activity | Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate. |
| oxalate transmembrane transporter activity | Catalysis of the transfer of oxalate from one side of the membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. |
| histone H3K79 methyltransferase activity | |
| exoribonuclease II activity | Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction. |
| L-tyrosine transmembrane transporter activity | Catalysis of the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid. |
| histone H3T3 kinase activity | |
| DNA exonuclease activity | |
| lysophosphatidic acid acyltransferase activity | Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid. |
| diacylglycerol cholinephosphotransferase activity | Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine. |
| pseudophosphatase activity | |
| ER retention sequence binding | Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. |
| phosphatidylglycerophosphatase activity | Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate. |
| L-glutamine, sodium:proton antiporter activity | |
| neutral amino acid, sodium:proton antiporter activity | |
| glutathione specific gamma-glutamylcyclotransferase activity | |
| hexosaminidase activity | Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides. |
| rRNA (adenine-N6,N6-)-dimethyltransferase activity | Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. |
| alcohol-forming long-chain fatty acyl-CoA reductase activity | |
| nitric oxide dioxygenase activity, heme protein as donor | |
| heparanase activity | Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains. |
| exo-alpha-sialidase activity | Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. |
| dicarboxylic acid transmembrane transporter activity | Catalysis of the transfer of dicarboxylic acids from one side of the membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups. |
| high-affinity sodium:dicarboxylate symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. |
| snRNP binding | Interacting selectively and non-covalently with any part of a small nuclear ribonucleoprotein particle. |
| (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity | |
| glycolipid mannosyltransferase activity | Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage. |
| L-lysine:L-arginine antiporter activity | |
| inositol 5-diphosphate pentakisphosphate 5-kinase activity | |
| diphosphoinositol tetrakisphosphate kinase activity | |
| 2-acylglycerophosphocholine O-acyltransferase activity | |
| lysophosphatidylethanolamine acyltransferase activity | |
| lysophosphatidic acid receptor activity | Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein. |
| alpha-1,3-mannosyltransferase activity | Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage. |
| dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity | Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. |
| histone H3K14ac reader activity | |
| peptide lactyltransferase (CoA-dependent) activity | |
| gamma-glutamyl-peptidase activity | Catalysis of the cleavage of a gamma-linked glutamate bond. |
| histone H3K9 acetyltransferase activity | |
| histone succinyltransferase activity | |
| histone glutaryltransferase activity | |
| growth hormone secretagogue receptor activity | Combining with ghrelin to initiate a change in cell activity. |
| BRE binding | Interacting selectively and non-covalently with the RNA element BRE (Bruno response element). |
| bilirubin transmembrane transporter activity | |
| telomerase inhibitor activity | Stops, prevents or reduces the activity of a telomerase. Telomerase catalyzes the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. |
| sodium:iodide symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in). |
| monoatomic anion:sodium symporter activity | |
| glutaryl-CoA dehydrogenase activity | Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor. |
| small conductance calcium-activated potassium channel activity | Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. |
| rRNA (pseudouridine) methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule. |
| ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity | Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA. |
| hepatocyte growth factor receptor binding | Interacting selectively and non-covalently with the hepatocyte growth factor receptor. |
| histone H2AK5 acetyltransferase activity | |
| peptide crotonyltransferase activity | |
| K11-linked deubiquitinase activity | |
| mRNA CDS binding | |
| ATP-gated ion channel activity | Catalysis of the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts. |
| betaine-homocysteine S-methyltransferase activity | Catalysis of the reaction: L-homocysteine + betaine = N,N-dimethylglycine + L-methionine. |
| homogentisate 1,2-dioxygenase activity | Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+). |
| interleukin-7 receptor binding | Interacting selectively and non-covalently with the interleukin-7 receptor. |
| corticotropin-releasing hormone receptor binding | Interacting selectively and non-covalently with a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland. |
| riboflavin kinase activity | Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+). |
| glutamine N-acyltransferase activity | Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine. |
| neutral L-amino acid:sodium symporter activity | |
| alanine:sodium symporter activity | |
| interleukin-22 binding | Interacting selectively and non-covalently with interleukin-22. |
| NEDD8 conjugating enzyme activity | |
| UDP-xylose transmembrane transporter activity | Catalysis of the transfer of UDP-xylose from one side of the membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate. |
| galactose 3-O-sulfotransferase activity | Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc. |
| proteoglycan sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans. |
| GDP-fucose transmembrane transporter activity | |
| arginine decarboxylase activity | |
| glycolipid floppase activity | |
| D-ribulose-phosphate 3-epimerase activity | |
| U2 snRNA binding | Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA). |
| D-loop DNA binding | |
| beta-3 adrenergic receptor binding | Interacting selectively and non-covalently with a beta-3 adrenergic receptor. |
| tRNA (uridine) methyltransferase activity | |
| N-acetyltaurine hydrolase activity | |
| aldose 1-epimerase activity | Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose. |
| rRNA methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. |
| phosphopantothenoylcysteine decarboxylase activity | Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H(+) = CO(2) + pantetheine 4'-phosphate. |
| mitochondrial ribosomal large subunit rRNA binding | |
| pyrimidine nucleotide transmembrane transporter activity | Catalysis of the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other. |
| dITP diphosphatase activity | Catalysis of the reaction: dITP + H2O = dIMP + diphosphate. |
| phosphodiesterase decapping endonuclease activity | |
| methionyl-tRNA formyltransferase activity | Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA. |
| ganglioside binding | Interacting selectively and non-covalently with a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues. |
| phosphorylase kinase regulator activity | Modulation of the activity of the enzyme phosphorylase kinase. |
| histone H3K14 deacetylase activity, NAD-dependent | |
| NAD-dependent protein-lysine depropionylase activity | |
| histone H4K12 deacetylase activity, hydrolytic mechanism | |
| histone H3K deacetylase activity | |
| NAD-dependent protein lysine delactylase activity | |
| NAD-dependent histone decrotonylase activity | |
| phosphatidylinositol-3,5-bisphosphate phosphatase activity | |
| N-sulfoglucosamine-3-sulfatase activity | |
| proline racemase activity | Catalysis of the reaction: L-proline = D-proline. |
| molybdenum cofactor sulfurtransferase activity | |
| mitochondrial ATP-gated potassium channel activity | |
| glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity | Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan. |
| type II interferon receptor binding | |
| corrinoid adenosyltransferase activity | |
| type 1 cannabinoid receptor binding | |
| Ala-tRNA(Thr) hydrolase activity | |
| mRNA (adenine-N1-)-methyltransferase activity | |
| phosphopentomutase activity | Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate. |
| tRNA-dihydrouridine47 synthase activity | |
| mRNA dihydrouridine synthase activity | |
| glutamate racemase activity | |
| myosin head/neck binding | Interacting selectively and non-covalently with the head/neck region of a myosin heavy chain. |
| rRNA (uridine-C5-)-methyltransferase activity | |
| methylthioribulose 1-phosphate dehydratase activity | Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O. |
| branched-chain amino acid transmembrane transporter activity | Catalysis of the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. |
| 4-hydroxybenzoate polyprenyltransferase activity | |
| SUMO-specific endopeptidase activity | |
| 2-oxoadipate dehydrogenase activity | |
| succinate-CoA ligase (GDP-forming) activity | Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate. |
| mannose-1-phosphate guanylyltransferase (GTP) activity | |
| 4-hydroxymandelate synthase activity | |
| peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity | Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue. |
| alcohol-forming very long-chain fatty acyl-CoA reductase activity | |
| histone H3K56 methyltransferase activity | |
| peptidyl-proline 4-dioxygenase activity | Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2. |
| galactosylxylosylprotein 3-beta-galactosyltransferase activity | Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP. |
| protein-arginine omega-N monomethyltransferase activity | Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. |
| histone H2AR3 methyltransferase activity | |
| mast cell secretagogue receptor activity | |
| calcium-dependent protein serine/threonine phosphatase regulator activity | Modulation of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase. |
| phospholipid:diacylglycerol acyltransferase activity | |
| urocanate hydratase activity | Catalysis of the reaction: 4-imidazolone-5-propanoate + H(+) = trans-urocanate + H(2)O. |
| neutral L-amino acid:sodium:chloride symporter activity | |
| folic acid:proton symporter activity | |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides | Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide. |
| 3'-flap endonuclease activity | Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis. |
| N-acetylneuraminate 9-O-acetyltransferase activity | |
| inositol hexakisphosphate 6-kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate. |
| methylmalonyl-CoA epimerase activity | Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA. |
| bicarbonate binding | |
| internal N(7)-methylguanine-containing RNA reader activity | |
| tRNA pseudouridine(13) synthase activity | |
| CCA tRNA nucleotidyltransferase activity | |
| 5'-3' RNA polymerase activity | |
| CCACCA tRNA nucleotidyltransferase activity | |
| mRNA N1-methyladenosine dioxygenase activity | |
| proline:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in). |
| acidic amino acid transmembrane transporter activity | Catalysis of the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7. |
| myo-inositol:proton symporter activity | |
| 1-aminocyclopropane-1-carboxylate synthase activity | Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+). |
| chenodeoxycholic acid binding | Interacting selectively and non-covalently with chenodeoxycholic acid. |
| sulfate:chloride antiporter activity | |
| methylcrotonoyl-CoA carboxylase activity | Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate. |
| biotin carboxylase activity | Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein. |
| L-amino-acid oxidase activity | Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide. |
| RNA cap trimethylguanosine synthase activity | |
| cysteamine dioxygenase activity | Catalysis of the reaction: cysteamine + O(2) = H(+) + hypotaurine. |
| N6-isopentenyladenosine methylthiotransferase activity | |
| selenocysteine insertion sequence binding | Interacting selectively and non-covalently with the selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation. |
| purine nucleotide binding | Interacting selectively and non-covalently with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate. |
| histone H3 ubiquitin ligase activity | |
| glutamate decarboxylase activity | Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. |
| 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity | Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor. |
| ethanolamine-phosphate cytidylyltransferase activity | Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine. |
| D-aspartate oxidase activity | Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide. |
| tyrosine 3-monooxygenase activator activity | Interacts with and increases tyrosine 3-monooxygenase (tyrosine hydroxylase) activity. |
| L-dopa decarboxylase activator activity | Interacts with and increases L-dopa decarboxylase activity. |
| glyoxalase (glycolic acid-forming) activity | Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor. |
| alpha-sialidase activity | Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids. |
| neurotensin receptor activity, non-G protein-coupled | |
| selenide, water dikinase activity | Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate. |
| L-asparagine, sodium:proton antiporter activity | |
| L-histidine, sodium:proton antiporter activity | |
| methionine synthase activity | Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine. |
| cholate 7-alpha-dehydrogenase (NAD+) activity | |
| 17-beta-hydroxysteroid dehydrogenase (NAD+) activity | Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+. |
| 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity | Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA. |
| chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity | |
| isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity | |
| ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity | |
| 3-demethoxyubiquinone 3-hydroxylase (NADH) activity | |
| calcium-dependent protein kinase inhibitor activity | Stops, prevents or reduces the activity of a calcium-dependent protein kinase. |
| TIR domain binding | Interacting selectively and non-covalently with a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. |
| N-methyltransferase activity | Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. |
| histone H2AX kinase activity | |
| galactosylceramide sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate. |
| D-threo-aldose 1-dehydrogenase activity | |
| C-rich strand telomeric DNA binding | |
| poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends | |
| vitamin-K-epoxide reductase (warfarin-insensitive) activity | |
| 2-(3-amino-3-carboxypropyl)histidine synthase activity | Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]. |
| NAD+ diphosphatase activity | Catalysis of the reaction: NAD+ + H2O = AMP + NMN. |
| RNA NAD-cap (NMN-forming) hydrolase activity | |
| ADP-specific glucokinase activity | Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate. |
| basal RNA polymerase II transcription machinery binding | Interacting selectively and non-covalently with the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase. |
| glucoside transmembrane transporter activity | Catalysis of the transfer of glucosides from one side of the membrane to the other. Glucosides are glycosides in which the sugar group is a glucose residue. |
| pyrimidine nucleotide-sugar transmembrane transporter activity | Catalysis of the transfer of a pyrimidine nucleotide-sugar from one side of the membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. |
| agmatinase activity | Catalysis of the reaction: agmatine + H(2)O = putrescine + urea. |
| guanidinobutyrase activity | |
| guanidinopropionase activity | |
| EP4 subtype prostaglandin E2 receptor binding | Interacting selectively and non-covalently with an EP4 subtype prostaglandin E2 receptor. |
| chitobiosyldiphosphodolichol beta-mannosyltransferase activity | Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol. |
| inositol bisphosphate phosphatase activity | Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate. |
| phosphatidylinositol trisphosphate phosphatase activity | Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate. |
| inositol trisphosphate phosphatase activity | Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate. |
| histone H4 reader activity | |
| snRNA methyltransferase activity | |
| alcohol dehydrogenase [NAD(P)+] activity | |
| thiamine triphosphate phosphatase activity | |
| tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity | |
| tRNA-specific adenosine deaminase activity | Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule. |
| dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase | |
| S-methyl-5-thioribose-1-phosphate isomerase activity | Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate. |
| tRNA (guanine(6)-N2)-methyltransferase activity | |
| tRNA (guanine(7)-N2)-methyltransferase activity | |
| enoyl-[acyl-carrier-protein] reductase (NADPH) activity | |
| AMPylase activity | |
| dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity | |
| dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity | |
| gamma-glutamylaminecyclotransferase activity | |
| rRNA (adenine) methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine. |
| tRNA (adenine(58)-N1)-methyltransferase activity | |
| H2A-H2B histone complex chaperone activity | |
| ADP-sugar diphosphatase activity | Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate. |
| N-acetylneuraminate lyase activity | Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate. |
| (1->3)-beta-D-glucan binding | Interacting selectively and non-covalently with (1->3)-beta-D-glucans. |
| tRNA-guanosine(34) queuine transglycosylase activity | |
| sulfate:bicarbonate antiporter activity | |
| formate transmembrane transporter activity | Catalysis of the transfer of formate from one side of the membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. |
| trans-2-enoyl-CoA reductase (NADPH) activity | Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+. |
| synaptic receptor adaptor activity | |
| glycoprotein 6-alpha-L-fucosyltransferase activity | Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H(+). |
| lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity | Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP. |
| intramolecular hydroxytransferase activity | |
| purine nucleotide uniporter activity | |
| (R)-3-amino-2-methylpropionate-pyruvate transaminase activity | Catalysis of the reaction: (2R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine. |
| 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity | |
| beta,beta-carotene-9',10'-cleaving oxygenase activity | |
| histone H3K4 dimethyltransferase activity | |
| histone H3K27 trimethyltransferase activity | |
| histone H3K27 dimethyltransferase activity | |
| endopeptidase regulator activity | Modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. |
| tRNA pseudouridine(38/39) synthase activity | |
| phosphatidylserine transfer activity | |
| sodium:sulfate symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in). |
| neuromedin U receptor activity | Combining with neuromedin U to initiate a change in cell activity. |
| neuromedin U binding | Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses. |
| threonine racemase activity | Catalysis of the reaction: L-threonine = D-threonine. |
| serine racemase activity | Catalysis of the synthesis of free D-serine from L-serine. |
| hypoxia-inducible factor-proline dioxygenase activity | |
| choline:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in). |
| interleukin-22 receptor binding | Interacting selectively and non-covalently with the interleukin-22 receptor. |
| inorganic diphosphate phosphatase activity | |
| secondary active organic cation transmembrane transporter activity | Catalysis of the transfer of organic cations from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. |
| mRNA N-acetyltransferase activity | |
| histone H3K4me3 reader activity | |
| tRNA 2'-phosphotransferase activity | Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate. |
| Atg12 transferase activity | Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y --> Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages. |
| Atg12 conjugating enzyme activity | |
| left-handed Z-DNA binding | Interacting selectively and non-covalently with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags. |
| protein-L-histidine N-pros-methyltransferase activity | |
| Atg8-family ligase activity | |
| glycosylceramidase activity | Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine. |
| palmitoleoyltransferase activity | |
| interleukin-17E receptor binding | Interacting selectively and non-covalently with the interleukin-17E receptor. |
| cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity | Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one. |
| branched-chain amino acid:sodium symporter activity | |
| S-methylmethionine-homocysteine S-methyltransferase activity | Catalysis of the reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H+. |
| diphthine methyl ester synthase activity | |
| potassium:chloride symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in). |
| tRNA dimethylallyltransferase activity | Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine. |
| UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol. |
| thiamine diphosphokinase activity | Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate. |
| UTP thiamine diphosphokinase activity | |
| dipeptide uniporter activity | |
| ribokinase activity | Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. |
| N(6)-L-threonylcarbamoyladenine synthase activity | |
| alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity | |
| mitochondrion-mitochondrion outer membrane tether activity | |
| mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am. |
| GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity | Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage. |
| GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity | |
| gamma-aminobutyric acid:proton symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in). |
| glycine:proton antiporter activity | |
| gamma-aminobutyric acid:proton antiporter activity | |
| carbohydrate kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. |
| rRNA (adenine-N6-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine. |
| 5'-3' DNA/RNA helicase activity | Catalysis of the unwinding of a DNA/RNA duplex in the direction 5' to 3'. |
| threonine-type endopeptidase activity | Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. |
| acetate-CoA ligase activity | Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. |
| propionate-CoA ligase activity | |
| protein-cysteine S-stearoyltransferase activity | |
| dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity | Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. |
| dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity | Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. |
| dCTP diphosphatase activity | Catalysis of the reaction: dCTP + H2O = dCMP + diphosphate. |
| [phosphorylase] phosphatase activity | |
| mRNA methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule. |
| polyprenal reductase activity | |
| inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity | |
| catalytic activity, acting on a tRNA | |
| protein carboxyl O-methyltransferase activity | Catalysis of the transfer of a methyl group to a carboxyl group on a protein. |
| endoribonuclease activity, cleaving miRNA-paired mRNA | |
| ribonuclease III activity | Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. |
| 2-hydroxyglutarate dehydrogenase activity | Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. |
| tRNA uridine(34) acetyltransferase activity | |
| riboflavin transmembrane transporter activity | |
| phosphopantothenate--cysteine ligase activity | Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives. |
| succinate-hydroxymethylglutarate CoA-transferase activity | Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate. |
| nicotinamide-nucleotide adenylyltransferase activity | Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+. |
| sialate O-acetylesterase activity | Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate. |
| beta-carotene 15,15'-dioxygenase activity | |
| stretch-activated, monoatomic cation-selective, calcium channel activity | |
| interleukin-21 receptor activity | Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| peptide deformylase activity | Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide. |
| arsenite methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate. |
| dCTP deaminase activity | |
| deoxynucleotide transmembrane transporter activity | Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP. |
| histone H2B ubiquitin ligase activity | |
| phosphate transmembrane transporter activity | Catalysis of the transfer of phosphate from one side of the membrane to the other. |
| inorganic diphosphate transmembrane transporter activity | Catalysis of the transfer of inorganic diphosphate across a membrane. |
| cyclic-nucleotide phosphodiesterase activity | Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. |
| steroid receptor RNA activator RNA binding | Interacting selectively and non-covalently with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding. |
| ABC-type manganese transporter activity | |
| ABC-type heme transporter activity | |
| carbohydrate response element binding | Interacting selectively and non-covalently with the carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes. |
| N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol. |
| ABC-type oligopeptide transporter activity | |
| ABC-type peptide transporter activity | |
| lactosylceramide 4-alpha-galactosyltransferase activity | Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP. |
| inositol-3-phosphate synthase activity | Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form. |
| ribosylnicotinamide kinase activity | Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H(+) + nicotinamide mononucleotide. |
| ribosylnicotinate kinase activity | |
| AF-1 domain binding | Interacting selectively and non-covalently with the AF-1 domain of a protein, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor. |
| Met1-linked polyubiquitin deubiquitinase activity | |
| omega-amidase activity | Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3. |
| recombination hotspot binding | Interacting selectively and non-covalently with a region in a genome which promotes recombination. |
| RNA polymerase inhibitor activity | |
| N-acylneuraminate-9-phosphate synthase activity | Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate. |
| sphingosine kinase activity | |
| D-erythro-sphingosine kinase activity | Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP. |
| sialic acid transmembrane transporter activity | Catalysis of the transfer of sialic acid from one side of the membrane to the other. |
| sialic acid:proton symporter activity | |
| myosin tail binding | Interacting selectively and non-covalently with the tail region of a myosin heavy chain. |
| protein-succinyllysine desuccinylase activity | Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide. |
| protein-glutaryllysine deglutarylase activity | |
| holo-[acyl-carrier-protein] synthase activity | Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. |
| protein histidine phosphatase activity | |
| arsenate reductase (glutaredoxin) activity | Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. |
| A-type (transient outward) potassium channel activity | Catalysis of the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential. |
| double-stranded DNA 3'-5' DNA exonuclease activity | |
| Atg8-family conjugating enzyme activity | |
| UDP-glucuronate transmembrane transporter activity | |
| 3'-tyrosyl-DNA phosphodiesterase activity | Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA. |
| G-rich single-stranded DNA binding | |
| fatty acyl-[ACP] hydrolase activity | |
| L-asparagine:sodium symporter activity | |
| L-glutamine:sodium symporter activity | |
| trimethyllysine dioxygenase activity | Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O(2) = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO(2) + succinate. |
| pyridoxamine phosphate oxidase activity | |
| UTP binding | Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate. |
| spermine oxidase activity | |
| 3-oxoacyl-[acyl-carrier-protein] synthase activity | Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. |
| tRNA guanylyltransferase activity | Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs. |
| Pyrin domain binding | Interacting selectively and non-covalently with a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain. |
| O-acetyl-ADP-ribose deacetylase activity | |
| 3',5'-nucleotide bisphosphate phosphatase activity | |
| tRNA dihydrouridine synthase activity | Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. |
| tRNA-dihydrouridine20 synthase activity | |
| sphingomyelin phosphodiesterase D activity | Catalysis of the reaction: H(2)O + sphingomyelin = ceramide 1-phosphate + choline + H(+). |
| tRNA (guanine(26)-N2)-dimethyltransferase activity | |
| MutLbeta complex binding | Interacting selectively and non-covalently with the mismatch repair complex MutLbeta. |
| MutSbeta complex binding | Interacting selectively and non-covalently with the mismatch repair complex MutSbeta. |
| bile acid-gated sodium channel activity | |
| (S)-2-hydroxy-acid oxidase activity | Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide. |
| UDP-glucose:glycoprotein glucosyltransferase activity | Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins. |
| interleukin-20 receptor binding | Interacting selectively and non-covalently with the interleukin-20 receptor. |
| very-long-chain enoyl-CoA reductase activity | |
| U5 snRNA binding | Interacting selectively and non-covalently with the U5 small nuclear RNA (U5 snRNA). |
| GTP 3',8'-cyclase activity | |
| cyclic pyranopterin monophosphate synthase activity | Catalysis of the reaction GTP = cyclic pyranopterin phosphate + diphosphate. |
| glycerophosphodiester phosphodiesterase activity | Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. |
| glycerophosphoinositol glycerophosphodiesterase activity | Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = sn-glycerol 3-phosphate + myo-inositol + H(+). |
| polyprenyldihydroxybenzoate methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + 3-polyprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-polyprenyl-4-hydroxy-5-methoxybenzoate + H+. |
| 3-demethylubiquinol 3-O-methyltransferase activity | |
| [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity | |
| sarcosine oxidase activity | Catalysis of the reaction: H(2)O + O(2) + sarcosine = formaldehyde + glycine + H(2)O(2). |
| L-pipecolate oxidase activity | Catalysis of the reaction: L-pipecolate + O(2) = 2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2) + H(+). Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate. |
| methyl-CpNpG binding | Interacting selectively and non-covalently with a methylated cytosine/unspecified/guanine trinucleotide. |
| succinate-CoA ligase (ADP-forming) activity | Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. |
| oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor | |
| [methionine synthase] reductase (NADPH) activity | |
| phosphatidylethanolamine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine. |
| 7-dehydrocholesterol reductase activity | Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+. |
| alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R. |
| acetylspermidine deacetylase activity | |
| tRNA (guanine(46)-N7)-methyltransferase activity | |
| internal mRNA (guanine-N7-)-methyltransferase activity | |
| alpha-1,4-N-acetylgalactosaminyltransferase activity | Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage. |
| hydroxypyruvate reductase (NADH) activity | |
| hydroxypyruvate reductase [NAD(P)H] activity | |
| glyoxylate reductase (NADPH) activity | |
| beta-ureidopropionase activity | Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3. |
| ghrelin receptor binding | Interacting selectively and non-covalently with a ghrelin receptor. |
| xylosylprotein 4-beta-galactosyltransferase activity | Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein. |
| deoxycytidyl transferase activity | Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA. |
| saccharopine dehydrogenase (NAD+, L-lysine-forming) activity | |
| saccharopine dehydrogenase (NADP+, L-lysine-forming) activity | Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = 2-oxoglutarate + L-lysine + H(+) + NADPH. |
| saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity | Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = L-glutamate + allysine + H(+) + NADH. |
| tRNA (guanine) methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine. |
| tRNA 2'-O-methyltransferase activity | |
| tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity | |
| phosphatidylserine decarboxylase activity | Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine. |
| inositol oxygenase activity | Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+). |
| L-ascorbate:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ascorbate(out) + Na+(out) = ascorbate(in) + Na+(in). |
| L-ascorbic acid transmembrane transporter activity | |
| zymogen binding | Interacting selectively and non-covalently with a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis. |
| oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP. |
| L-cysteine-S-conjugate N-acetyltransferase activity | |
| prenylcysteine oxidase activity | Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2. |
| sedoheptulokinase activity | Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H(+) + sedoheptulose 7-phosphate. |
| alpha-methylacyl-CoA racemase activity | Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA. |
| DNA polymerase processivity factor activity | An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it. |
| acireductone synthase activity | Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. |
| dimethylglycine dehydrogenase activity | Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein. |
| rRNA (uridine-2'-O-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine. |
| protein C-terminal leucine carboxyl O-methyltransferase activity | |
| histone H2AXY142 kinase activity | |
| peptide-methionine (S)-S-oxide reductase activity | Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. |
| N-acetylglucosamine kinase activity | Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H(+). |
| muramyl dipeptide kinase activity | |
| 2-hydroxyacyl-CoA lyase activity | |
| cardiolipin synthase (CMP-forming) | |
| 18S rRNA aminocarboxypropyltransferase activity | |
| glyoxylate oxidase activity | Catalysis of the reaction: glyoxylate + H(2)O + O(2) = H(2)O(2) + H(+) + oxalate. |
| NADP phosphatase activity | |
| NADPH phosphatase activity | |
| RNA lariat debranching enzyme activity | Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide. |
| carnitine O-octanoyltransferase activity | Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA. |
| cytoskeletal regulatory protein binding | Interacting selectively and non-covalently with any protein involved in modulating the reorganization of the cytoskeleton. |
| histone H3K14 deacetylase activity, hydrolytic mechanism | |
| histone H4K16 deacetylase activity, hydrolytic mechanism | |
| endoribonuclease activity, cleaving siRNA-paired mRNA | Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters. |
| citrate-L-glutamate ligase activity | Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate. |
| myosin I binding | |
| histone arginine deiminase activity | |
| histone H3R2 arginine deiminase activity | |
| histone H3R8 arginine deiminase activity | |
| histone H3R17 arginine deiminase activity | |
| histone H3R26 arginine deiminase activity | |
| thiolester hydrolase activity | Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. |
| D-glucose:proton symporter activity | |
| beta-alanine transmembrane transporter activity | |
| neutral, basic amino acid:sodium:chloride symporter activity | |
| lactosylceramide alpha-2,3-sialyltransferase activity | Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3. |
| 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity | Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA. |
| sterol 12-alpha-hydroxylase activity | Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O. |
| inositol-hexakisphosphate phosphatase activity | Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate. |
| inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity | |
| bisphosphoglycerate 3-phosphatase activity | Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phospho-D-glycerate + phosphate. |
| inositol hexakisphosphate 2-phosphatase activity | Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate. |
| inositol pentakisphosphate phosphatase activity | Catalysis of the reaction: myo-inositol pentakisphosphate + H2O = myo-inositol tetrakisphosphate + phosphate. |
| low-affinity phosphate transmembrane transporter activity | Catalysis of the transfer of phosphate from one side of the membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. |
| hedgehog receptor activity | Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity. |
| RNA polymerase core enzyme binding | Interacting selectively and non-covalently with an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme. |
| myosin II head/neck binding | |
| dolichol kinase activity | Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate. |
| calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration | |
| cystine:glutamate antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out). |
| L-kynurenine transmembrane transporter activity | |
| talin binding | Interacting selectively and non-covalently with a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types. |
| double-stranded DNA 5'-3' DNA exonuclease activity | |
| UDP-N-acetylglucosamine 2-epimerase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine. |
| N-acylmannosamine kinase activity | Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate. |
| nicotinate transmembrane transporter activity | |
| crotonyl-CoA hydratase activity | |
| lipoyltransferase activity | |
| bent DNA binding | |
| pantothenate transmembrane transporter activity | |
| ribitol beta-1,4-xylosyltransferase activity | |
| N-acetylglucosaminylphosphatidylinositol deacetylase activity | Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane. |
| chondroitin 2-sulfotransferase activity | |
| dermatan 2-sulfotransferase activity | |
| flap-structured DNA binding | Interacting selectively and non-covalently with a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule. |
| type II interferon binding | |
| cholate-CoA ligase activity | Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA. |
| L-gulonate 3-dehydrogenase activity | Catalysis of the reaction: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH. |
| galactose:proton symporter activity | |
| N-acetylgalactosamine-6-phosphate deacetylase activity | |
| N-acetylglucosamine-6-phosphate deacetylase activity | Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate. |
| deoxyribose-phosphate aldolase activity | Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. |
| Ras palmitoyltransferase activity | Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins. |
| 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity | |
| UFM1 conjugating enzyme activity | |
| RNA ligase (GTP) activity | |
| voltage-gated potassium channel activity involved in SA node cell action potential depolarization | |
| dGTPase activity | Catalysis of the reaction: dGTP + H(2)O = 2'-deoxyguanosine + 2 H(+) + triphosphate. |
| dGTP binding | Interacting selectively and non-covalently with dGTP, deoxyguanosine triphosphate. |
| deoxynucleoside triphosphate hydrolase activity | |
| histone H2AT120 kinase activity | |
| histone H3K9me/H3K9me2 demethylase activity | |
| cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity | |
| purine nucleoside binding | Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose. |
| somatostatin receptor binding | Interacting selectively and non-covalently with a somatostatin receptor. |
| protein C-terminal methylesterase activity | Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol. |
| protein-glutamine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine. |
| histone H4K12 methyltransferase activity | |
| ceramide transfer activity | |
| protein-(glutamine-N5) methyltransferase activity | |
| sulfinoalanine decarboxylase activity | Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2. |
| O-phospho-L-serine:2-oxoglutarate aminotransferase activity | Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. |
| dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity | Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. |
| dolichyl-phosphate beta-glucosyltransferase activity | Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate. |
| Hsp27 protein binding | |
| cysteine desulfurase activity | Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. |
| cholesterol 24-hydroxylase activity | Catalysis of the reaction: cholesterol + H(+) + NADPH + O(2) = (24S)-24-hydroxycholesterol + H(2)O + NADP(+). |
| NAD-dependent protein lipoamidase activity | |
| NAD-dependent protein biotinidase activity | |
| sulfide:quinone oxidoreductase activity | Catalysis of the reaction: hydrogen sulfide + a quinone = S0 + a hydroquinone. |
| glutathione-dependent sulfide quinone oxidoreductase activity | |
| alpha-1,3-galactosyltransferase activity | Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage. |
| N-acetyllactosaminide 3-alpha-galactosyltransferase activity | |
| single-strand break-containing DNA binding | |
| taste receptor binding | Interacting selectively and non-covalently with a taste receptor. |
| deoxyribonuclease I activity | Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products. |
| 3'-nucleotidase activity | Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate. |
| urotensin II receptor activity | Combining with urotensin II to initiate a change in cell activity. |
| ADP-ribosyl-[dinitrogen reductase] hydrolase activity | |
| A1 adenosine receptor binding | Interacting selectively and non-covalently with an A1 adenosine receptor. |
| 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity | |
| U1 snRNP binding | |
| netrin receptor activity | Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| neuromedin U receptor binding | Interacting selectively and non-covalently with one or more specific sites on a neuromedin U receptor. |
| riboflavin binding | |
| glyoxalase III activity | Catalysis of the reaction: methylglyoxal + H2O = D-lactate. |
| hemoglobin alpha binding | Interacting selectively and non-covalently with a hemoglobin alpha chain. |
| type 1 melanin-concentrating hormone receptor binding | |
| uracil binding | Interacting selectively and non-covalently with uracil. |
| dimethylallyltranstransferase activity | Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. |
| neuropeptide Y receptor binding | Interacting selectively and non-covalently with a neuropeptide Y receptor. |
| imidazolonepropionase activity | Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H(2)O = N-formimidoyl-L-glutamate + H(+). |
| acetolactate synthase activity | |
| gonadotropin-releasing hormone receptor activity | Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. |
| bis(5'-adenosyl)-hexaphosphatase activity | |
| G protein-coupled serotonin receptor binding | |
| N-acylneuraminate cytidylyltransferase activity | Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate. |
| 1-pyrroline-5-carboxylate dehydrogenase activity | Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+). |
| corticosterone 18-monooxygenase activity | Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O. |
| interleukin-11 binding | Interacting selectively and non-covalently with interleukin-11. |
| glucosaminyl-phosphatidylinositol O-acyltransferase activity | |
| pristanoyl-CoA oxidase activity | Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide. |
| P-type ion transporter activity | |
| polyprenol reductase activity | |
| carotenoid dioxygenase activity | |
| type 2 orexin receptor binding | |
| nucleosome array spacer activity | |
| dopamine receptor binding | Interacting selectively and non-covalently with a dopamine receptor. |
| galanin receptor binding | Interacting selectively and non-covalently with a galanin receptor. |
| acylphosphatase activity | Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate. |
| NAD(P)HX epimerase activity | |
| IgG receptor activity | Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity | |
| deoxynucleoside kinase activity | Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate. |
| dihydroorotate dehydrogenase activity | Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate. |
| GTP cyclohydrolase binding | Interacting selectively and non-covalently with a GTP cyclohydrolase. |
| branched-chain-amino-acid transaminase activity | Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. |
| glutamate-cysteine ligase regulator activity | |
| fatty-acyl-CoA synthase activity | Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+. |
| gonadotropin hormone-releasing hormone activity | The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary. |
| voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | |
| double-stranded DNA endonuclease activity | |
| RNA transmembrane transporter activity | Catalysis of the transfer of RNA, ribonucleic acid, from one side of a membrane to the other. |
| D5 dopamine receptor binding | Interacting selectively and non-covalently with a D5 dopamine receptor. |
| interleukin-20 binding | Interacting selectively and non-covalently with interleukin-20. |
| ribonuclease MRP activity | Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA. |
| tRNA-specific adenosine-34 deaminase activity | |
| MAP kinase tyrosine phosphatase activity | |
| calcium-dependent protein serine/threonine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions are dependent on the presence of calcium ions. |
| prolactin-releasing peptide receptor binding | Interacting selectively and non-covalently with a prolactin-releasing peptide receptor. |
| U12 snRNA binding | |
| UDP-N-acetylglucosamine diphosphorylase activity | Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine. |
| rRNA (uridine-N3-)-methyltransferase activity | |
| alpha-1,6-mannosyltransferase activity | Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage. |
| D4 dopamine receptor binding | Interacting selectively and non-covalently with a D4 dopamine receptor. |
| beta-N-acetylglucosaminidase activity | Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides. |
| protein-N-terminal-glutamate acetyltransferase activity | |
| acid-amino acid ligase activity | Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| S-formylglutathione hydrolase activity | Catalysis of the reaction: S-formylglutathione + H(2)O = formate + glutathione + H(+). |
| N6-threonylcarbomyladenosine methylthiotransferase activity | Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A). |
| globoside alpha-N-acetylgalactosaminyltransferase activity | Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP. |
| D-lactate dehydrogenase (cytochrome) activity | Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c. |
| large ribosomal subunit rRNA binding | |
| leukotriene B4 receptor activity | Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate. |
| RNA lariat debranching enzyme activator activity | |
| D-xylose 1-dehydrogenase (NADP+) activity | Catalysis of the reaction: D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH. |
| gluconokinase activity | Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H(+). |
| RNA polymerase III core binding | Interacting selectively and non-covalently with RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits. |
| gonadotropin-releasing hormone receptor binding | |
| dCMP deaminase activity | Catalysis of the reaction: dCMP + H2O = dUMP + NH3. |
| kisspeptin receptor binding | |
| polynucleotide 5'-hydroxyl-kinase activity | Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. |
| D-tyrosyl-tRNA(Tyr) deacylase activity | Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA. |
| G protein-coupled glutamate receptor binding | |
| tRNA N4-acetyltransferase activity | |
| inositol tetrakisphosphate kinase activity | Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP. |
| interleukin-33 binding | Interacting selectively and non-covalently with interleukin-33. |
| deoxyribonuclease II activity | Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products. |
| hepatocyte growth factor receptor activity | |
| tRNA-intron endonuclease activity | Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. |
| RNA strand-exchange activity | |
| amidophosphoribosyltransferase activity | Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O. |
| adenine/guanine mispair binding | |
| pre-mRNA 5'-splice site binding | |
| alpha-(1->6)-fucosyltransferase activity | Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage. |
| cupric reductase (NADH) activity | |
| corticotropin-releasing hormone activity | The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary. |
| putrescine binding | |
| dTDP-glucose 4,6-dehydratase activity | Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O. |
| D-ribulokinase activity | |
| type 1 orexin receptor binding | |
| GDP-mannose hydrolase activity | |
| delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity | |
| fumarylacetoacetase activity | Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+). |
| D-lactate dehydrogenase activity | |
| single-stranded DNA exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule. |
| substance K receptor activity | Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity. |
| IgE receptor activity | Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| short-chain carboxylesterase activity | Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms. |
| glucagon receptor binding | Interacting selectively and non-covalently with a glucagon receptor. |
| adenosine kinase activity | Catalysis of the reaction: ATP + adenosine = ADP + AMP. |
| 18S rRNA cytidine N-acetyltransferase activity | |
| oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. |
| CDP-glycerol diphosphatase activity | Catalysis of the reaction: CDP-glycerol + H(2)O = sn-glycerol 3-phosphate + CMP + 2 H(+). |
| palmitoyl-CoA 9-desaturase activity | |
| GDP-mannose transmembrane transporter activity | |
| glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose. |
| neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration | |
| methylated-DNA-[protein]-cysteine S-methyltransferase activity | Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. |
| cysteinyl leukotriene receptor activity | Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine. |
| squalene synthase [NAD(P)H] activity | |
| vitamin D binding | Interacting selectively and non-covalently with vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). |
| sodium-dependent multivitamin transmembrane transporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate. |
| sulfite oxidase activity | Catalysis of the reaction: H(2)O + O(2) + sulfite = H(2)O(2) + H(+) + sulfate. |
| acireductone dioxygenase [iron(II)-requiring] activity | Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate + H(+). |
| adenine binding | Interacting selectively and non-covalently with adenine, a purine base. |
| amino acid kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate. |
| mu-type opioid receptor binding | Interacting selectively and non-covalently with a mu-type opioid receptor. |
| oxytocin receptor binding | Interacting selectively and non-covalently with an oxytocin receptor. |
| alkylglycerophosphoethanolamine phosphodiesterase activity | Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate. |
| thiosulfate transmembrane transporter activity | |
| phosphoglycerate dehydrogenase activity | Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. |
| L-methionine-(S)-S-oxide reductase activity | |
| peptide YY receptor activity | Combining with gut peptide YY to initiate a change in cell activity. |
| spermidine binding | Interacting selectively and non-covalently with spermidine, N-(3-aminopropyl)-1,4-diaminobutane. |
| DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates | Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA). |
| hydroxypyruvate isomerase activity | Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate. |
| 3-demethoxyubiquinol 3-hydroxylase activity | |
| 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity | |
| prostacyclin receptor activity | |
| corticotropin-releasing hormone receptor 1 binding | Interacting selectively and non-covalently with the corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system. |
| threonine synthase activity | Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate. |
| para-aminobenzoyl-glutamate hydrolase activity | |
| JUN kinase phosphatase activity | Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate. |
| serine O-acyltransferase activity | Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule. |
| glucosamine 6-phosphate N-acetyltransferase activity | Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+). |
| D3 dopamine receptor binding | Interacting selectively and non-covalently with a D3 dopamine receptor. |
| melanocortin receptor binding | Interacting selectively and non-covalently with a melanocortin receptor. |
| group II metabotropic glutamate receptor activity | A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity. |
| thyrotropin-releasing hormone activity | The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary. |
| oligopeptidase activity | Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds. |
| CXCR4 chemokine receptor binding | Interacting selectively and non-covalently with a CXCR4 chemokine receptor. |
| UDP-N-acetylgalactosamine transmembrane transporter activity | |
| (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity | |
| 4-alpha-hydroxytetrahydrobiopterin dehydratase activity | Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O. |
| glycerol-3-phosphate dehydrogenase [NAD(P)+] activity | |
| thyrotropin-releasing hormone receptor activity | Combining with thyrotropin-releasing hormone to initiate a change in cell activity. |
| sarcosine dehydrogenase activity | Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein. |
| exopolyphosphatase activity | |
| 3'-tRNA processing endoribonuclease activity | |
| guanine deaminase activity | Catalysis of the reaction: guanine + H2O = xanthine + NH3. |
| saccharopine dehydrogenase activity | Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor. |
| alkylbase DNA N-glycosylase activity | Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site. |
| phosphoribosylaminoimidazolecarboxamide formyltransferase activity | Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide. |
| interleukin-13 receptor binding | Interacting selectively and non-covalently with the interleukin-13 receptor. |
| parathyroid hormone receptor binding | Interacting selectively and non-covalently with a parathyroid hormone receptor. |
| purine-specific nucleoside:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in). |
| oxytocin receptor activity | Combining with oxytocin to initiate a change in cell activity. |
| diphthine methylesterase activity | |
| UFM1 transferase activity | Catalysis of the transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y --> Y-UFM1 + X, where both X-UFM1 and Y-UFM1 are covalent linkages. |
| (2E,6E)-farnesyl diphosphate synthase activity | |
| interleukin-9 binding | Interacting selectively and non-covalently with interleukin-9. |
| neuromedin B receptor binding | Interacting selectively and non-covalently with a neuromedin B receptor. |
| nitrate transmembrane transporter activity | Catalysis of the transfer of nitrate ions (NO3-) from one side of a membrane to the other. |
| granulocyte colony-stimulating factor receptor binding | Interacting selectively and non-covalently with the granulocyte colony-stimulating factor receptor. |
| recombinase activator activity | |
| glycerophosphocholine phosphodiesterase activity | Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline. |
| interleukin-9 receptor binding | Interacting selectively and non-covalently with the interleukin-9 receptor. |
| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity | Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate. |
| solute:monoatomic cation symporter activity | |
| carbohydrate:monoatomic cation symporter activity | |
| mannose transmembrane transporter activity | Catalysis of the transfer of mannose from one side of the membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. |
| BH domain binding | Interacting selectively and non-covalently with the Bcl-2 homology (BH) domain of a protein. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains. |
| intracellularly calcium-gated channel activity | |
| ubiquitin-like protein conjugating enzyme activity | |
| anion binding | Interacting selectively and non-covalently with anions, charged atoms or groups of atoms with a net negative charge. |
| aminoacyl-tRNA ligase activity | Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. |
| transmitter-gated monoatomic ion channel activity | |
| rRNA (cytosine) methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine. |
| transmembrane receptor protein serine/threonine kinase binding | Interacting selectively and non-covalently with a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity. |
| ion channel regulator activity | |
| nucleobase-containing compound kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. |
| adenyl ribonucleotide binding | Interacting selectively and non-covalently with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. |
| histone phosphatase activity | |
| gated channel activity | Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus. |
| transmembrane receptor protein kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. |
| icosanoid binding | Interacting selectively and non-covalently with icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids. |
| icosatetraenoic acid binding | Interacting selectively and non-covalently with icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule. |
| nuclease inhibitor activity | |
| pyruvate dehydrogenase [NAD(P)+] activity | |
| nucleobase:monoatomic cation symporter activity | |
| G protein-coupled chemoattractant receptor activity | |
| poly-purine tract binding | Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule. |
| CoA carboxylase activity | Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| vitamin B6 binding | |
| alkali metal ion binding | Interacting selectively and non-covalently with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen. |
| acyl-CoA desaturase activity | Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = desaturated-acyl-CoA + acceptor + 2 H2O. |
| transmembrane receptor protein phosphatase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. |
| glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity | |
| oxidoreduction-driven active transmembrane transporter activity | |
| bis(5'-nucleosyl)-tetraphosphatase activity | Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides. |
| CDP-alcohol phosphatidyltransferase activity | Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol. |
| arginine N-methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue. |
| DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group. |
| histone H3 kinase activity | |
| serine-type exopeptidase activity | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| heparan sulfate sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate. |
| histone H3 demethylase activity | |
| phosphatidylinositol monophosphate phosphatase activity | Catalysis of the reaction: phosphatidylinositol monophosphate + H2O = phosphatidylinositol + phosphate. |
| phosphatidylinositol-4,5-bisphosphate phosphatase activity | |
| carbon-nitrogen ligase activity, with glutamine as amido-N-donor | Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. |
| O-acetyltransferase activity | Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule. |
| oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. |
| C-palmitoyltransferase activity | Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule. |
| intramolecular phosphotransferase activity | |
| phosphatidylinositol-3,4-bisphosphate phosphatase activity | |
| ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | Catalysis of the transfer of ions from one side of a membrane to the other according to the reaction: ATP + H2O + ion(in) = ADP + phosphate + ion(out), by a rotational mechanism. |
| secondary active monocarboxylate transmembrane transporter activity | Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism. |
| ATPase-coupled monocarboxylic acid transmembrane transporter activity | |
| nucleotide transmembrane transporter activity | Catalysis of the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other. |
| procollagen-proline dioxygenase activity | Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2. |
| oxidized base lesion DNA N-glycosylase activity | Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. |
| nucleotide receptor activity | Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. |
| oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor | |
| monocarboxylic acid binding | Interacting selectively and non-covalently with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-). |
| sulfate adenylyltransferase activity | Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate. |
| oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound. |
| trehalase activity | Catalysis of the hydrolysis of trehalose or a trehalose derivative. |
| phosphotransferase activity, phosphate group as acceptor | Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). |
| inositol phosphate kinase activity | |
| neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | |
| phenanthrene-epoxide hydrolase activity | Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene. |
| DNA endonuclease activity, producing 3'-phosphomonoesters | |
| inorganic anion transmembrane transporter activity | Catalysis of the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. |
| bicarbonate:monoatomic anion antiporter activity | |
| glycerophospholipid flippase activity | |
| hydrolase activity, hydrolyzing N-glycosyl compounds | Catalysis of the hydrolysis of any N-glycosyl bond. |
| purine ribonucleotide transmembrane transporter activity | Catalysis of the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other. |
| beta-1,3-galactosyltransferase activity | Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage. |
| hexose phosphate transmembrane transporter activity | Catalysis of the transfer of hexose phosphate from one side of the membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule. |
| hexose-phosphate:phosphate antiporter activity | |
| isocitrate dehydrogenase [NAD(P)+] activity | |
| oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. |
| sterol desaturase activity | Catalysis of the introduction of a double bond into a sterol molecule. |
| mannosyl-oligosaccharide mannosidase activity | Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides. |
| IgM receptor activity | |
| secondary active transmembrane transporter activity | Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Chemiosmotic sources of energy include uniport, symport or antiport. |
| solute:potassium antiporter activity | |
| phosphofructokinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a fructose substrate molecule. |
| calcitonin family binding | Interacting selectively and non-covalently with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)). |
| phosphoric ester hydrolase activity | Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. |
| sulfur amino acid transmembrane transporter activity | Catalysis of the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives. |
| oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. |
| histone H4 demethylase activity | |
| amidine-lyase activity | Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate. |
| inhibitory extracellular ligand-gated monoatomic ion channel activity | |
| citrate synthase activity | Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA. |
| cell-matrix adhesion mediator activity | |
| amino acid:monoatomic cation antiporter activity | |
| C4-dicarboxylate transmembrane transporter activity | Catalysis of the transfer of C4-dicarboxylate from one side of the membrane to the other. |
| temperature-gated ion channel activity | Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism). |
| NADPH dehydrogenase activity | |
| steroid 7-alpha-hydroxylase activity | Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O. |
| oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. |
| postsynaptic neurotransmitter receptor activity | |
| adenyl nucleotide binding | Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate. |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines | Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. |
| L-glutamine aminotransferase activity | Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid. |
| pyrimidine-nucleoside phosphorylase activity | Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate. |
| mismatch base pair DNA N-glycosylase activity | Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. |
| pentosyltransferase activity | |
| tyrosyl-DNA phosphodiesterase activity | Catalysis of the hydrolysis of phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA. |
| prenyl diphosphate synthase activity | |
| phosphotransferase activity, nitrogenous group as acceptor | Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor). |
| hydroxymethyl-, formyl- and related transferase activity | Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor). |
| ammonia-lyase activity | Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. |
| nucleic acid conformation isomerase activity | |
| lactate dehydrogenase activity | Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate. |
| oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor. |
| carboxyl- or carbamoyltransferase activity | Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor). |
| nucleobase binding | Interacting selectively and non-covalently with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases. |
| purine phosphoribosyltransferase activity | |
| adenylyltransferase activity | Catalysis of the transfer of an adenylyl group to an acceptor. |
| phosphotransferase activity, carboxyl group as acceptor | Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). |
| oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines | Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. |
| C5a anaphylatoxin chemotactic receptor binding | Interacting selectively and non-covalently with a C5a anaphylatoxin chemotactic receptor. |
| neurotrophin receptor binding | Interacting selectively and non-covalently with a neurotrophin receptor. |
| vasopressin receptor binding | Interacting selectively and non-covalently with a vasopressin receptor. |
| vasoactive intestinal polypeptide receptor binding | |
| fucosidase activity | Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative. |
| amylase activity | Catalysis of the hydrolysis of amylose or an amylose derivative. |
| fatty acid omega-hydroxylase activity | |
| fatty acid omega-1 hydroxylase activity | |
| 5,10-methylenetetrahydrofolate-dependent methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate. |
| oligosaccharyl transferase activity | Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
| P-type sodium transporter activity | |
| P-type potassium transmembrane transporter activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor. |
| oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule. |
| bombesin receptor binding | Interacting selectively and non-covalently with a bombesin receptor. |
| galactosidase activity | Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative. |
| intramolecular oxidoreductase activity, interconverting aldoses and ketoses | Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. |
| oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen. |
| proteinase-activated receptor activity | |
| G protein-coupled amine receptor activity | |
| G protein-coupled neurotransmitter receptor activity | |
| pyruvate dehydrogenase activity | Catalysis of the oxidative decarboxylation of pyruvate. |
| oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. |
| adrenergic receptor activity | Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex. |
| vitamin D 23-hydroxylase activity | |
| alpha-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors. |
| C-acyltransferase activity | Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule. |
| CoA-transferase activity | Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor). |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor. |
| sugar-phosphatase activity | Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate. |
| regulatory RNA binding | |
| cyclase activator activity | Increases the activity of an enzyme that catalyzes a ring closure reaction. |
| anandamide epoxidase activity | |
| monosaccharide transmembrane transporter activity | Catalysis of the transfer of a monosaccharide from one side of a membrane to the other. |
| endothelial differentiation G protein-coupled receptor binding | |
| oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin. |
| cyclohydrolase activity | Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring. |
| diphosphotransferase activity | Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor). |
| DNA insertion or deletion binding | Interacting selectively and non-covalently with double-stranded DNA containing insertions or deletions. |
| deaminated base DNA N-glycosylase activity | DNA N-glycosylase activity acting on deaminated bases. |
| N-succinyltransferase activity | Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule. |
| intracellularly ATP-gated ion channel activity | |
| polypeptide conformation or assembly isomerase activity | |
| alpha-1,4-glucan glucosyltransferase (NDP-glucose donor) activity | |
| intramolecular oxidoreductase activity, interconverting keto- and enol-groups | Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears. |
| beta-fructofuranosidase activity | Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside. |
| hexose uniporter activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor. |
| ammonia ligase activity | Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. |
| interferon binding | Interacting selectively and non-covalently with an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent. |
| cyclic nucleotide-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a cyclic nucleotide. |
| aromatic-amino-acid transaminase activity | |
| steroid dehydrogenase activity, acting on the CH-CH group of donors | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor, and in which one substrate is a sterol derivative. |
| neurotrophin TRK receptor binding | Interacting selectively and non-covalently with a neurotrophin TRK receptor. |
| threonine-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. |
| neurokinin receptor binding | Interacting selectively and non-covalently with a neurokinin receptor. |
| P-type proton-exporting transporter activity | |
| histone H3 reader activity | |
| thromboxane receptor activity | Combining with a thromboxane (TXA) to initiate a change in cell activity. |
| succinate dehydrogenase activity | Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor. |
| oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound. |
| peptide serotonyltransferase activity | |
| peptide dopaminyltransferase activity | |
| histone H2A methyltransferase activity | |
| cyclo-ligase activity | Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| ferredoxin-[NAD(P)H] reductase activity | |
| sequence-specific single stranded DNA binding | |
| adenosine-phosphate deaminase activity | Catalysis of the reaction: an adenosine-phosphate + H20 = an inosine phosphate + NH3. Catalyzes the deamination of AMP, ADP or ATP. |
| malate dehydrogenase activity | Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. |
| oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group. |
| inositol trisphosphate kinase activity | Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP. |
| carnitine O-acyltransferase activity | Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule. |
| deoxynucleoside-phosphate kinase activity, ATP as phosphate donor | |
| oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group. |
| alanine-oxo-acid transaminase activity | Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid. |
| phosphoric triester hydrolase activity | |
| lactonohydrolase activity | |
| DNA exonuclease activity, producing 5'-phosphomonoesters | |
| 11-beta-hydroxysteroid dehydrogenase [NAD(P)+] activity | |
| interleukin-12 binding | Interacting selectively and non-covalently with interleukin-12. |
| interleukin-17 binding | Interacting selectively and non-covalently with any member of the interleukin-17 family of cytokines. |
| thioredoxin-dependent peroxiredoxin activity | |
| UMP/dUMP kinase activity | |
| GTP cyclohydrolase activity | Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. |
| enone reductase activity | Catalysis of the reaction: an enone + NADPH + H+ = a ketone + NADP+. |
| amino acid:monoatomic cation symporter activity | |
| inositol tetrakisphosphate phosphatase activity | Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate. |
| cholecystokinin receptor binding | Interacting selectively and non-covalently with a cholecystokinin receptor. |
| sugar-terminal-phosphatase activity | Catalysis of the reaction: H2O + sugar phosphorylated on the terminal carbon = a sugar + phosphate. |
| oxo-acid-lyase activity | Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. |
| oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen. |
| oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor | |
| prostanoid receptor activity | Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity. |
| oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen. |
| cyclic GMP-AMP binding | |
| RNA polymerase III cis-regulatory region sequence-specific DNA binding | |
| 5S rDNA binding | Interacting selectively and non-covalently with the 5S rDNA sequence encoding ribosomal 5S rRNA, which is individually transcribed by RNA polymerase III, rather than by RNA polymerase I, in species where it exists. |
| D-amino acid transmembrane transporter activity | |
| oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. |
| oligopeptide transmembrane transporter activity | Catalysis of the transfer of oligopeptides from one side of the membrane to the other. |
| oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
| oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. |
| oxidosqualene cyclase activity | Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene. |
| sphingolipid transfer activity | |
| metal cation:monoatomic cation antiporter activity | |
| S-acetyltransferase activity | Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule. |
| hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides | |
| protoporphyrinogen oxidase activity | Catalysis of the reaction: protoporphyrinogen IX + acceptor = protoporphyrin IX + reduced acceptor. |
| G protein-coupled pyrimidinergic nucleotide receptor activity | |
| oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule. |
| fatty aldehyde dehydrogenase (NAD+) activity | |
| succinate-semialdehyde dehydrogenase [NAD(P)+] activity | |
| endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters. |
| tricarboxylate secondary active transmembrane transporter activity | |
| acyltransferase activity, acyl groups converted into alkyl on transfer | |
| histone H2B kinase activity | |
| potassium:sodium symporter activity | |
| membrane potential driven uniporter activity | |
| carbon-oxygen lyase activity, acting on phosphates | Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate. |
| G protein-coupled nucleotide receptor binding | |
| narrow pore channel activity | Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated. |
| L-amino-acid N-acetyltransferase activity | |
| autophagosome-membrane adaptor activity | |
| endoplasmic reticulum-organelle membrane tether activity | |
| G protein-coupled glutamate receptor activity | |
| oxidoreductase activity, acting on NAD(P)H as acceptor | |
| cyclase inhibitor activity | Decreases the activity of an enzyme that catalyzes a ring closure reaction. |
| 2-alkenal reductase [NAD(P)+] activity | |
| icosanoid receptor activity | Combining with an icosanoid to initiate a change in cell activity. |
| cyclic nucleotide-activated monoatomic ion channel activity | |
| DNA photolyase activity | Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA. |
| hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances | Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group. |
| UTP-monosaccharide-1-phosphate uridylyltransferase activity | Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide. |
| monoatomic ion-gated channel activity | |
| sucrose:monoatomic cation symporter activity | |
| ATP-dependent polynucleotide 5'-hydroxyl-kinase activity | |
| histone deubiquitinase activity | |
| guanyl nucleotide binding | Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. |
| ferric-chelate reductase activity | Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H(+). |
| prostanoid receptor binding | Interacting selectively and non-covalently with a prostanoid receptor. |
| organophosphate:phosphate antiporter activity | |
| oligonucleotidase activity | |
| short-chain fatty acyl-CoA hydrolase activity | |
| oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen. |
| tRNA (adenine) methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine. |
| dermatan sulfotransferase activity | |
| chondroitin sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate. |
| acid-ammonia (or amide) ligase activity | Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. |
| S-malonyltransferase activity | Catalysis of the transfer of a malonyl group to a sulfur atom on the acceptor molecule. |
| histone H4K deacetylase activity | |
| methionine transmembrane transporter activity | Catalysis of the transfer of methionine from one side of a membrane to the other. |
| snoRNP binding | |
| intramolecular aminotransferase activity | |
| histone deacetylase activity, hydrolytic mechanism | |
| cyclic GMP-AMP synthase activity | |
| endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. |
| high-affinity basic amino acid transmembrane transporter activity | Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. |
| RNA ligase activity | Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the 5'-phosphate group at the end of another. |
| fluoride transmembrane transporter activity | |
| monoatomic cation efflux transmembrane transporter activity | |
| histone H4 ubiquitin ligase activity | |
| peptide N-succinyltransferase activity | |
| peptide glutaryltransferase activity | |
| purine nucleotide-sugar transmembrane transporter activity | |
| catalytic activity, acting on a rRNA | |
| NAD-dependent protein decrotonylase activity | |
| phosphatidylinositol bisphosphate phosphatase activity | Catalysis of the reaction: phosphatidylinositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate. |
| amino-acid racemase activity | Catalysis of the reaction: an L-amino acid = a D-amino acid. |
| cannabinoid receptor binding | |
| RNA dihydrouridine synthase activity | |
| rRNA (uridine) methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine. |
| ubiquitin-like protein-specific endopeptidase activity | |
| succinate-CoA ligase activity | Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA. |
| RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template. |
| methylthiotransferase activity | Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor. |
| phosphotransferase activity, paired acceptors | Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors. |
| azole:proton antiporter activity | |
| 5-methyltetrahydrofolate-dependent methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate. |
| calcium-dependent protein kinase regulator activity | Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner. |
| beta-1,4-mannosyltransferase activity | Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage. |
| enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H) | |
| glycolipid 1,6-alpha-mannosyltransferase activity | |
| short-chain fatty acid-CoA ligase activity | |
| inositol pentakisphosphate kinase activity | |
| carboxyl-O-methyltransferase activity | Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester. |
| double-stranded RNA-specific ribonuclease activity | Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules. |
| oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide. |
| pyrimidine ribonucleotide binding | Interacting selectively and non-covalently with a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. |
| glyoxylate reductase activity | |
| oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin. |
| phosphatidyltransferase activity | |
| histone H3 arginine deiminase activity | |
| hexose:proton symporter activity | |
| triphosphoric monoester hydrolase activity | Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group. |
| guanyl deoxyribonucleotide binding | Interacting selectively and non-covalently with a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety. |
| oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound. |
| melanin-concentrating hormone receptor binding | |
| pyrimidine nucleobase binding | Interacting selectively and non-covalently with a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton. |
| orexin receptor binding | |
| oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule. |
| ribonuclease activator activity | |
| L-methionine:thioredoxin-disulfide S-oxidoreductase activity | |
| diphosphoric monoester hydrolase activity | Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group. |
