LINCS KinomeScan Kinase Inhibitor Targets Dataset

Description kinase inhibitor targets from percent inhibition of kinases by small molecules measured using purified kinases
Measurement chemical bioactivity
Association kinase-small molecule associations by percent inhibition of kinase by small molecule
Category physical interactions
Resource LINCS KinomeScan
Last Updated 2015 Apr 06
Stats
  1. 277 genes
  2. 71 small molecules
  3. 2057 gene-small molecule associations

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small molecule Gene Sets

71 sets of kinases inhibited by small molecules from the KinomeScan Kinase Inhibitor Targets dataset.

Gene Set Description
(R)- Roscovitine
5z-7-oxozeaenol A macrolide that is the 7-oxo derivative of zeaenol (the 5Z stereoisomer). Isolated from Fungi, it exhibits cytotoxic, antibacterial and inhibitory activity against NF-kappaB.
AG1478
ALW-II-38-3
AS601245
AZ-628
AZD 5438
AZD-6482
AZD4547 A member of the class of benzamides that is a carboxamide resulting from the formal condensation of the carboxy group of 4-(cis-3,5-dimethylpiperazin-1-yl)benzoic acid with the amino substituent of 5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-amine. It is an inhibitor of the fibroblast growth factor receptor (FGFR).
Barasertib
BEZ235
BMS345541
Bosutinib
BS-181
BX-912
CG-930
CGP60474
CGP74514A
CP466722
CP724714
Crizotinib
Dabrafenib An organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma.
Dinaciclib
GDC-0941
GSK1059615 A thiazolidinone that is the 5-{[4-(pyridin-4-yl)quinolin-6-yl]methylene} derivative of 1,3-thiazolidine-2,4-dione. A PI3K inhibitor
GSK2126458
GSK429286A
GSK461364
GW-5074
GW843682
HG-14-8-02
HG-6-64-01
JNK-9L
JWE-035
KIN001-220
KU63794
Lapatinib
MLN8054
Momelotinib
Neratinib A quinoline compound having a cyano group at the 3-position, a 3-chloro-4-(2-pyridylmethoxy)anilino group at the 4-position, a 4-dimethylamino-trans-but-2-enamido group at the 6-position, and an ethoxy group at the 7-position.
NU7441
OTSSP167
PD0332991
PHA-767491
PHA-793887
PLX-4720
PLX4032
QL-X-138
QL-XI-92
RO-3306
SB590885
Sigma A6730
Sorafenib
TAK-715
THZ-2-98-01
Torin1 A member of the class of pyridoquinolines that is 9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2-one bearing an additional 4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl substituent at position 1.
Torin2
WYE-125132
WZ-7043
WZ3105
XMD-12
XMD11-50
XMD11-85h
XMD13-2
XMD14-99
XMD15-27
XMD16-144
XMD8-85
XMD8-92 A dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one carrying at C-2 on the pyrimidine ring a [2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino substituent. It is an inhibitor of the BMK1 kinase pathway.
ZG-10
ZM-447439