| Description | Oncogenic signatures of genes differentially expressed following cancer gene perturbations |
| Measurement | gene expression by microarray or RNA-seq |
| Association | gene-gene associations by differential expression of gene A following perturbation of gene B |
| Category | transcriptomics |
| Resource | Molecular Signatures Database |
| Citation(s) | |
| Last Updated | 2015 Apr 06 |
| Stats |
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Attribute Similarity
Gene Attribute
Gene Similarity
90 sets of genes differentially expressed following gene perturbations from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
| Gene Set | Description |
|---|---|
| AKT_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| AKT_UP_MTOR_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| ALK_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| ATF2_S_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| ATF2_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| ATM_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| BCAT.100_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| BCAT_BILD_ET_AL | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| BCAT_GDS748 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| BMI1_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| BMI1_DN_MEL18_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| BRCA1_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| CAMP_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| CRX_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| CRX_NRL_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| CSR_EARLY_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| CSR_LATE_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| CTIP_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| CYCLIN_D1_KE_.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| CYCLIN_D1_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| DCA_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| E2F1_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| E2F3_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| EGFR_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| EIF4E | eukaryotic translation initiation factor 4E|The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
| ERB2_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| ESC_J1_UP_EARLY.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| ESC_J1_UP_LATE.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| ESC_V6.5_UP_EARLY.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| ESC_V6.5_UP_LATE.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| GCNP_SHH_UP_EARLY.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| GCNP_SHH_UP_LATE.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| GLI1_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| HOXA9_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| IL15_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| IL21_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| IL2_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| JAK2_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| JNK_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| KRAS.300_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| KRAS.50_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| KRAS.600.LUNG.BREAST_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| KRAS.600_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| KRAS.AMP.LUNG_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| KRAS.BREAST_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| KRAS.DF.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| KRAS.KIDNEY_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| KRAS.LUNG.BREAST_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| KRAS.LUNG_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| KRAS.PROSTATE_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| LEF1_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| LTE2_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| MEK_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| MEL18_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| MTOR_UP.N4.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| MTOR_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| MYC_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| NOTCH_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| NRL_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| P53_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| P53_DN.V2 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| PDGF_ERK_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| PDGF_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| PIGF_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| PKCA_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| PRC1_BMI_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| PRC2_EDD_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| PRC2_EZH2_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| PRC2_SUZ12_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| PTEN_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| PTEN_DN.V2 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| RAF_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| RAPA_EARLY_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| RB_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| RB_P107_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| RB_P130_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| RELA_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| RPS14_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| SIRNA_EIF4GI | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| SNF5_DN.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| SRC_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| STK33 | serine/threonine kinase 33| |
| STK33_NOMO | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| STK33_SKM | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| TBK1.DF | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| TBK1.DN.48HRS | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| TGFB_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| VEGF_A_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| WNT_UP.V1 | gene perturbation identified as [gene symbol]_[perturbation or condition] |
| YAP1 | Yes-associated protein 1|This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013] |
