| Description | Sets of proteins participating in pathways from PANTHER |
| Measurement | association by literature curation |
| Association | protein-pathway associations from curated pathways |
| Category | structural or functional annotations |
| Resource | PANTHER |
| Citation(s) |
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| Last Updated | 2014 Dec 17 |
| Stats |
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Attribute Similarity
Gene Attribute
Gene Similarity
145 sets of proteins participating in pathways from the PANTHER Pathways dataset.
| Gene Set | Description |
|---|---|
| 5-arachidonylglycerol_biosynthesis | |
| 5-Hydroxytryptamine biosynthesis | |
| 5-Hydroxytryptamine degredation | |
| 5HT1 type receptor mediated signaling pathway | |
| 5HT2 type receptor mediated signaling pathway | |
| 5HT3 type receptor mediated signaling pathway | |
| 5HT4 type receptor mediated signaling pathway | |
| Acetate utilization | |
| Adenine and hypoxanthine salvage pathway | |
| Adrenaline and noradrenaline biosynthesis | |
| Alanine biosynthesis | The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid. |
| Allantoin degradation | The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea. |
| Alpha adrenergic receptor signaling pathway | |
| Alzheimer disease-amyloid secretase pathway | |
| Alzheimer disease-presenilin pathway | |
| Aminobutyrate degradation | |
| Anandamide_degradation | |
| Androgen/estrogene/progesterone biosynthesis | |
| Angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin | |
| Apoptosis signaling pathway | |
| Arginine biosynthesis | The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. |
| Ascorbate degradation | |
| Asparagine and aspartate biosynthesis | |
| ATP synthesis | The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| Axon guidance mediated by netrin | |
| Axon guidance mediated by semaphorins | |
| Axon guidance mediated by Slit/Robo | |
| B cell activation | The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. |
| Beta1 adrenergic receptor signaling pathway | |
| Beta2 adrenergic receptor signaling pathway | |
| Beta3 adrenergic receptor signaling pathway | |
| Blood coagulation | The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. |
| Bupropion_degradation | |
| Cadherin signaling pathway | |
| Carnitine metabolism | The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. |
| Cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| Cholesterol biosynthesis | The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
| Circadian clock system | |
| Coenzyme A biosynthesis | The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. |
| Coenzyme A linked carnitine metabolism | |
| Cortocotropin releasing factor receptor signaling pathway | |
| Cytoskeletal regulation by Rho GTPase | |
| De novo purine biosynthesis | The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. |
| De novo pyrimidine deoxyribonucleotide biosynthesis | |
| De novo pyrimidine ribonucleotides biosythesis | |
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| EGF receptor signaling pathway | A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| Endogenous_cannabinoid_signaling | |
| Enkephalin release | |
| FAS signaling pathway | A series of molecular signals initiated by the binding of a ligand to the receptor Fas on the surface of the cell, and ending with regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily. |
| FGF signaling pathway | The family of fibroblast growth factors (FGF) comprises 22 ligands classified into seven phylogenetic subfamilies and three groups by mode of action: the intracellular intracrine and the extracellular paracrine or canonical and endocrine or hormone-like groups. The paracrine subfamilies signal via the fibroblast growth factor receptors (FGFR), receptor tyrosine kinases (RTK). The endocrine subfamily is FGFR-dependent but the affinity towards the receptors is low and relies on Klotho family of transmembrane proteins. The intracrine subfamily is FGFR-independent. Overall, the pathway plays important roles during embryonic and postnatal development, neuromodulation, mineral metabolism and homeostasis. Deregulation of the pathway has been associated with neoplastic and metabolic diseases. |
| Flavin biosynthesis | |
| Formyltetrahydroformate biosynthesis | |
| Fructose galactose metabolism | |
| GABA-B_receptor_II_signaling | |
| Gamma-aminobutyric acid synthesis | The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. |
| General transcription by RNA polymerase I | |
| General transcription regulation | |
| Glutamine glutamate conversion | |
| Glycolysis | The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. |
| Hedgehog signaling pathway | A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. |
| Heme biosynthesis | The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. |
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |
| Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction | |
| Histamine H1 receptor mediated signaling pathway | |
| Histamine H2 receptor mediated signaling pathway | |
| Histamine synthesis | The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. |
| Huntington disease | |
| Hypoxia response via HIF activation | |
| Inflammation mediated by chemokine and cytokine signaling pathway | |
| Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade | |
| Insulin/IGF pathway-protein kinase B signaling cascade | |
| Integrin signalling pathway | |
| Interferon-gamma signaling pathway | |
| Interleukin signaling pathway | |
| Ionotropic glutamate receptor pathway | |
| Isoleucine biosynthesis | The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. |
| JAK/STAT signaling pathway | The Jak-Stat pathway is a main intracellular cascade initiated primarily in response to cytokine and also other ligand signaling. Four Janus kinases (Jak) and seven signal transducers and activators of transcription (Stat) families of proteins mediate the action of almost 40 cytokine receptors, including the receptor for leptin. Combinations between four Jak(s) and seven Stat(s) shape the outcome of ligand triggered signaling through the various receptors. |
| Leucine biosynthesis | The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. |
| Lipoate_biosynthesis | The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. |
| Mannose metabolism | The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. |
| Metabotropic glutamate receptor group I pathway | |
| Metabotropic glutamate receptor group II pathway | |
| Metabotropic glutamate receptor group III pathway | |
| Methionine biosynthesis | The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. |
| Methylcitrate cycle | |
| Methylmalonyl pathway | |
| mRNA splicing | |
| Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |
| N-acetylglucosamine metabolism | The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. |
| Nicotine pharmacodynamics pathway | The pathway of nicotine-target interaction and of the biochemical or physiological responses to them. Nicotine is an agonist of the nicotinic acetylcholine receptors and exerts stimulatory roles. It is also responsible for tobacco dependence. Prolonged exposure and high levels of nicotine can have toxic effects. Genetic variations can cause differences in the response of the organism to the drug. |
| Nicotine_degradation | The chemical reactions and pathways resulting in the breakdown of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine. |
| Nicotinic acetylcholine receptor signaling pathway | |
| Notch signaling pathway | A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
| O-antigen biosynthesis | The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide. |
| Opioid proenkephalin pathway | |
| Opioid proopiomelanocortin pathway | |
| Ornithine degradation | The chemical reactions and pathways resulting in the breakdown of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. |
| Oxidative stress response | |
| Oxytocin receptor mediated signaling pathway | |
| p38 MAPK pathway | |
| p53 pathway | |
| p53 pathway by glucose deprivation | |
| P53 pathway feedback loops 1 | |
| p53 pathway feedback loops 2 | |
| Parkinson disease | A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)|A neurodegenerative disease that results_from degeneration of the central nervous system that often impairs the sufferer's motor skills, speech, and other functions. |
| PDGF signaling pathway | PDGF signaling pathway plays an important role in the regulation of cell growth and survival. |
| Pentose phosphate pathway | The process in which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. |
| Phenylethylamine degradation | The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds. |
| PI3 kinase pathway | |
| Plasminogen activating cascade | |
| PNAT | |
| Purine metabolism | The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). |
| Pyridoxal phosphate salvage pathway | |
| Pyridoxal-5-phosphate biosynthesis | |
| Pyrimidine Metabolism | |
| Pyruvate metabolism | The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. |
| Ras Pathway | |
| S-adenosylmethionine biosynthesis | The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. |
| Salvage pyrimidine deoxyribonucleotides | |
| Salvage pyrimidine ribonucleotides | |
| Serine glycine biosynthesis | |
| Succinate to proprionate conversion | |
| Synaptic_vesicle_trafficking | The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body. |
| T cell activation | The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. |
| TCA cycle | A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. |
| Tetrahydrofolate biosynthesis | The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. |
| TGF-beta signaling pathway | |
| Thiamine metabolism | The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. |
| Threonine biosynthesis | The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. |
| Thyrotropin-releasing hormone receptor signaling pathway | |
| Toll receptor signaling pathway | |
| Transcription regulation by bZIP transcription factor | |
| Triacylglycerol metabolism | The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins. |
| Ubiquitin proteasome pathway | |
| Valine biosynthesis | The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid. |
| Vasopressin synthesis | |
| VEGF signaling pathway | |
| Vitamin B6 metabolism | The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. |
| Vitamin D metabolism and pathway | |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
| Xanthine and guanine salvage pathway |
