223 sets of proteins participating in pathways from the PID Pathways dataset.
| Gene Set |
Description |
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TNF receptor signaling pathway
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Signaling events mediated by PRL
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IL5-mediated signaling events
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Rapid glucocorticoid signaling
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DNA-PK pathway in nonhomologous end joining
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Validated transcriptional targets of AP1 family members Fra1 and Fra2
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Beta5 beta6 beta7 and beta8 integrin cell surface interactions
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Integrin family cell surface interactions
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Posttranslational regulation of adherens junction stability and dissassembly
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Sphingosine 1-phosphate (S1P) pathway
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Internalization of ErbB1
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PDGF receptor signaling network
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JNK signaling in the CD4+ TCR pathway
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RhoA signaling pathway
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Class I PI3K signaling events mediated by Akt
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FoxO family signaling
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ATM pathway
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The p53-dependent pathway of G1 arrest in response to damaged DNA.
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IL8-mediated signaling events
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TCR signaling in naïve CD4+ T cells
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a4b7 Integrin signaling
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S1P3 pathway
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Endothelins
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Beta2 integrin cell surface interactions
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Downstream signaling in naïve CD8+ T cells
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Integrins in angiogenesis
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LPA receptor mediated events
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Alternative NF-kappaB pathway
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E-cadherin signaling in the nascent adherens junction
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Netrin-mediated signaling events
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Integrin-linked kinase signaling
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Signaling events mediated by focal adhesion kinase
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Caspase Cascade in Apoptosis
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EPHA2 forward signaling
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Nectin adhesion pathway
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Regulation of RAC1 activity
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Syndecan-4-mediated signaling events
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VEGFR3 signaling in lymphatic endothelium
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Regulation of CDC42 activity
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Validated nuclear estrogen receptor alpha network
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IL4-mediated signaling events
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Class I PI3K signaling events
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Ras signaling in the CD4+ TCR pathway
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
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ErbB receptor signaling network
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Visual signal transduction: Cones
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PLK1 signaling events
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PDGFR-beta signaling pathway
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A series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
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Polo-like kinase signaling events in the cell cycle
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Fanconi anemia pathway
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Interstrand cross links (ICL) of DNA can be induced by both endogenous and exogenous ligands. ICL if not repaired will lead to cell death. ICL repair pathway, also known as Fanconi anemia pathway is the cellular response to this type of DNA damage.
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S1P4 pathway
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Thrombin/protease-activated receptor (PAR) pathway
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TCR signaling in naïve CD8+ T cells
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Validated transcriptional targets of TAp63 isoforms
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Hedgehog signaling events mediated by Gli proteins
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Signaling events mediated by PTP1B
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BARD1 signaling events
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Nephrin/Neph1 signaling in the kidney podocyte
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Trk receptor signaling mediated by PI3K and PLC-gamma
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CDC42 signaling events
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IL1-mediated signaling events
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Endogenous TLR signaling
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Signaling events mediated by VEGFR1 and VEGFR2
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BCR signaling pathway
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Proteoglycan syndecan-mediated signaling events
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Regulation of Telomerase
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Regulation of p38-alpha and p38-beta
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ErbB2/ErbB3 signaling events
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Plexin-D1 Signaling
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Signaling events mediated by HDAC Class II
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a6b1 and a6b4 Integrin signaling
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Aurora A signaling
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Wnt signaling network
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Arf6 downstream pathway
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Insulin Pathway
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Signaling mediated by p38-gamma and p38-delta
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CD40/CD40L signaling
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LPA4-mediated signaling events
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Regulation of nuclear beta catenin signaling and target gene transcription
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ATF-2 transcription factor network
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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ATR signaling pathway
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The ATM and Rad3-related (ATR) serine/threonine kinase mediated signaling responds to several kinds of DNA damage, of which single-stranded DNA (ssDNA) exerts a key role. ssDNAs are induced by stressed replication forks. ATR acting on its substrates prevents the cell from erroneous mitotic entry, plays a key role in interstrand cross link (ICL) repair pathway and also exerts important regulatory roles in homologous recombination pathway of double-strand break repair.
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Alpha6 beta4 integrin-ligand interactions
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CXCR3-mediated signaling events
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Calcium signaling in the CD4+ TCR pathway
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Ephrin B reverse signaling
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PDGFR-alpha signaling pathway
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VEGFR1 specific signals
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IL12 signaling mediated by STAT4
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ALK1 signaling events
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S1P2 pathway
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Signaling events mediated by the Hedgehog family
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SHP2 signaling
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IL23-mediated signaling events
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Presenilin action in Notch and Wnt signaling
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FAS (CD95) signaling pathway
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Arf1 pathway
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Signaling by Aurora kinases
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Arf6 signaling events
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S1P1 pathway
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Alpha-synuclein signaling
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IFN-gamma pathway
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Signaling events mediated by HDAC Class I
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PLK3 signaling events
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ALK2 signaling events
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EphrinA-EPHA pathway
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IL27-mediated signaling events
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Regulation of Ras family activation
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Neurotrophic factor-mediated Trk receptor signaling
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IL8- and CXCR1-mediated signaling events
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mTOR signaling pathway
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mTOR signaling pathway regulates cellular processes such as translation, ribosome biogenesis, cell growth and autophagy and is regulated or responds to growth factors, energy metabolites and/or levels of nutrients.
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p75(NTR)-mediated signaling
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Alpha4 beta1 integrin signaling events
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Class IB PI3K non-lipid kinase events
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Angiopoietin receptor Tie2-mediated signaling
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FOXA1 transcription factor network
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Signaling events mediated by HDAC Class III
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E2F transcription factor network
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S1P5 pathway
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p38 MAPK signaling pathway
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A SAPK MAPK pathway that plays an important role in inflammation and may be involved in several forms of cancer.
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AP-1 transcription factor network
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Ceramide signaling pathway
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Ceramide signaling can act as a lipid second messenger or as a mediator of various cellular signaling pathways by promoting receptor clustering. The pathway plays important roles in apoptosis.
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Cellular roles of Anthrax toxin
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E-cadherin signaling events
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IL2-mediated signaling events
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Glucocorticoid receptor regulatory network
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HIV-1 Nef: Negative effector of Fas and TNF-alpha
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Glypican 3 network
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PAR1-mediated thrombin signaling events
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Sumoylation by RanBP2 regulates transcriptional repression
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BMP receptor signaling
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Glypican 2 network
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Canonical NF-kappaB pathway
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Noncanonical Wnt signaling pathway
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The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin.
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p38 signaling mediated by MAPKAP kinases
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ErbB1 downstream signaling
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IL2 signaling events mediated by STAT5
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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FOXA transcription factor networks
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Regulation of cytoplasmic and nuclear SMAD2/3 signaling
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Syndecan-2-mediated signaling events
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PAR4-mediated thrombin signaling events
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Insulin-mediated glucose transport
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PLK2 and PLK4 events
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HIF-2-alpha transcription factor network
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amb2 Integrin signaling
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Degradation of beta catenin
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Beta1 integrin cell surface interactions
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p73 transcription factor network
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Beta3 integrin cell surface interactions
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EPHA forward signaling
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Regulation of retinoblastoma protein
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Nongenotropic Androgen signaling
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Direct p53 effectors
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Arf6 trafficking events
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Signaling events mediated by TCPTP
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Regulation of nuclear SMAD2/3 signaling
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Validated targets of C-MYC transcriptional repression
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Aurora C signaling
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Circadian rhythm pathway
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Reelin signaling pathway
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Reelin signaling pathway regulates neuronal positioning and may also play a role in synaptic plasticity. The reelin gene appears to be downregulated in the schizophrenic brains but the link between the reelin pathway and the disease remains to be established.
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Trk receptor signaling mediated by the MAPK pathway
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IL2 signaling events mediated by PI3K
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IL12-mediated signaling events
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EGF receptor (ErbB1) signaling pathway
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Fc-epsilon receptor I signaling in mast cells
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Regulation of Androgen receptor activity
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Any process that modulates the frequency, rate or extent of androgen receptor activity.
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VEGF and VEGFR signaling network
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C-MYB transcription factor network
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EphrinB-EPHB pathway
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IL8- and CXCR2-mediated signaling events
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Alpha9 beta1 integrin signaling events
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Syndecan-1-mediated signaling events
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N-cadherin signaling events
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Validated targets of C-MYC transcriptional activation
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Visual signal transduction: Rods
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EPO signaling pathway
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Erythropoietin (EPO) signaling is crucial for the production of blood cell or erythropoiesis and also plays important roles in wound healing and responses to neural injury. EPO is a glycoprotein hormone and also a cytokine whose receptor belongs to type I cytokine receptor. The pathway engages the Jak-Stat intracellular cascade.
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Atypical NF-kappaB pathway
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CXCR4-mediated signaling events
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Plasma membrane estrogen receptor signaling
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HIF-1-alpha transcription factor network
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Aurora B signaling
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FOXA2 and FOXA3 transcription factor networks
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Ephrin A reverse signaling
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TRAIL signaling pathway
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Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
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EPHB forward signaling
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GMCSF-mediated signaling events
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IL6-mediated signaling events
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p53 pathway
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FOXM1 transcription factor network
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EGFR-dependent Endothelin signaling events
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RXR and RAR heterodimerization with other nuclear receptor
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Glypican pathway
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Signaling events regulated by Ret tyrosine kinase
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Syndecan-3-mediated signaling events
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FGF signaling pathway
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The family of fibroblast growth factors (FGF) comprises 22 ligands classified into seven phylogenetic subfamilies and three groups by mode of action: the intracellular intracrine and the extracellular paracrine or canonical and endocrine or hormone-like groups. The paracrine subfamilies signal via the fibroblast growth factor receptors (FGFR), receptor tyrosine kinases (RTK). The endocrine subfamily is FGFR-dependent but the affinity towards the receptors is low and relies on Klotho family of transmembrane proteins. The intracrine subfamily is FGFR-independent. Overall, the pathway plays important roles during embryonic and postnatal development, neuromodulation, mineral metabolism and homeostasis. Deregulation of the pathway has been associated with neoplastic and metabolic diseases.
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Osteopontin-mediated events
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Coregulation of Androgen receptor activity
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Stabilization and expansion of the E-cadherin adherens junction
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IGF1 pathway
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RAC1 signaling pathway
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Notch-mediated HES/HEY network
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ErbB4 signaling events
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C-MYC pathway
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Retinoic acid receptors-mediated signaling
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Effects of Botulinum toxin
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AlphaE beta7 integrin cell surface interactions
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Notch signaling pathway
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A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
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TGF-beta receptor signaling
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IL3-mediated signaling events
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Regulation of RhoA activity
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Canonical Wnt signaling pathway
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The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
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Thromboxane A2 receptor signaling
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Validated nuclear estrogen receptor beta network
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Glypican 1 network
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E-cadherin signaling in keratinocytes
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Lissencephaly gene (LIS1) in neuronal migration and development
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Signaling mediated by p38-alpha and p38-beta
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Validated transcriptional targets of deltaNp63 isoforms
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LKB1 signaling events
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ALK1 pathway
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