223 sets of proteins participating in pathways from the PID Pathways dataset.
Gene Set |
Description |
a4b7 Integrin signaling
|
|
a6b1 and a6b4 Integrin signaling
|
|
ALK1 pathway
|
|
ALK1 signaling events
|
|
ALK2 signaling events
|
|
Alpha-synuclein signaling
|
|
Alpha4 beta1 integrin signaling events
|
|
Alpha6 beta4 integrin-ligand interactions
|
|
Alpha9 beta1 integrin signaling events
|
|
AlphaE beta7 integrin cell surface interactions
|
|
Alternative NF-kappaB pathway
|
|
amb2 Integrin signaling
|
|
Angiopoietin receptor Tie2-mediated signaling
|
|
AP-1 transcription factor network
|
|
Arf1 pathway
|
|
Arf6 downstream pathway
|
|
Arf6 signaling events
|
|
Arf6 trafficking events
|
|
ATF-2 transcription factor network
|
|
ATM pathway
|
The p53-dependent pathway of G1 arrest in response to damaged DNA.
|
ATR signaling pathway
|
The ATM and Rad3-related (ATR) serine/threonine kinase mediated signaling responds to several kinds of DNA damage, of which single-stranded DNA (ssDNA) exerts a key role. ssDNAs are induced by stressed replication forks. ATR acting on its substrates prevents the cell from erroneous mitotic entry, plays a key role in interstrand cross link (ICL) repair pathway and also exerts important regulatory roles in homologous recombination pathway of double-strand break repair.
|
Atypical NF-kappaB pathway
|
|
Aurora A signaling
|
|
Aurora B signaling
|
|
Aurora C signaling
|
|
BARD1 signaling events
|
|
BCR signaling pathway
|
|
Beta1 integrin cell surface interactions
|
|
Beta2 integrin cell surface interactions
|
|
Beta3 integrin cell surface interactions
|
|
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
|
|
BMP receptor signaling
|
|
C-MYB transcription factor network
|
|
C-MYC pathway
|
|
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
|
|
Calcium signaling in the CD4+ TCR pathway
|
|
Canonical NF-kappaB pathway
|
|
Canonical Wnt signaling pathway
|
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
|
Caspase Cascade in Apoptosis
|
|
CD40/CD40L signaling
|
|
CDC42 signaling events
|
|
Cellular roles of Anthrax toxin
|
|
Ceramide signaling pathway
|
Ceramide signaling can act as a lipid second messenger or as a mediator of various cellular signaling pathways by promoting receptor clustering. The pathway plays important roles in apoptosis.
|
Circadian rhythm pathway
|
|
Class I PI3K signaling events
|
|
Class I PI3K signaling events mediated by Akt
|
|
Class IB PI3K non-lipid kinase events
|
|
Coregulation of Androgen receptor activity
|
|
CXCR3-mediated signaling events
|
|
CXCR4-mediated signaling events
|
|
Degradation of beta catenin
|
|
Direct p53 effectors
|
|
DNA-PK pathway in nonhomologous end joining
|
|
Downstream signaling in naïve CD8+ T cells
|
|
E-cadherin signaling events
|
|
E-cadherin signaling in keratinocytes
|
|
E-cadherin signaling in the nascent adherens junction
|
|
E2F transcription factor network
|
|
Effects of Botulinum toxin
|
|
EGF receptor (ErbB1) signaling pathway
|
|
EGFR-dependent Endothelin signaling events
|
|
Endogenous TLR signaling
|
|
Endothelins
|
|
EPHA forward signaling
|
|
EPHA2 forward signaling
|
|
EPHB forward signaling
|
|
Ephrin A reverse signaling
|
|
Ephrin B reverse signaling
|
|
EphrinA-EPHA pathway
|
|
EphrinB-EPHB pathway
|
|
EPO signaling pathway
|
Erythropoietin (EPO) signaling is crucial for the production of blood cell or erythropoiesis and also plays important roles in wound healing and responses to neural injury. EPO is a glycoprotein hormone and also a cytokine whose receptor belongs to type I cytokine receptor. The pathway engages the Jak-Stat intracellular cascade.
|
ErbB receptor signaling network
|
|
ErbB1 downstream signaling
|
|
ErbB2/ErbB3 signaling events
|
|
ErbB4 signaling events
|
|
Fanconi anemia pathway
|
Interstrand cross links (ICL) of DNA can be induced by both endogenous and exogenous ligands. ICL if not repaired will lead to cell death. ICL repair pathway, also known as Fanconi anemia pathway is the cellular response to this type of DNA damage.
|
FAS (CD95) signaling pathway
|
|
Fc-epsilon receptor I signaling in mast cells
|
|
FGF signaling pathway
|
The family of fibroblast growth factors (FGF) comprises 22 ligands classified into seven phylogenetic subfamilies and three groups by mode of action: the intracellular intracrine and the extracellular paracrine or canonical and endocrine or hormone-like groups. The paracrine subfamilies signal via the fibroblast growth factor receptors (FGFR), receptor tyrosine kinases (RTK). The endocrine subfamily is FGFR-dependent but the affinity towards the receptors is low and relies on Klotho family of transmembrane proteins. The intracrine subfamily is FGFR-independent. Overall, the pathway plays important roles during embryonic and postnatal development, neuromodulation, mineral metabolism and homeostasis. Deregulation of the pathway has been associated with neoplastic and metabolic diseases.
|
FOXA transcription factor networks
|
|
FOXA1 transcription factor network
|
|
FOXA2 and FOXA3 transcription factor networks
|
|
FOXM1 transcription factor network
|
|
FoxO family signaling
|
|
Glucocorticoid receptor regulatory network
|
|
Glypican 1 network
|
|
Glypican 2 network
|
|
Glypican 3 network
|
|
Glypican pathway
|
|
GMCSF-mediated signaling events
|
|
Hedgehog signaling events mediated by Gli proteins
|
|
HIF-1-alpha transcription factor network
|
|
HIF-2-alpha transcription factor network
|
|
HIV-1 Nef: Negative effector of Fas and TNF-alpha
|
|
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
|
|
IFN-gamma pathway
|
|
IGF1 pathway
|
|
IL1-mediated signaling events
|
|
IL12 signaling mediated by STAT4
|
|
IL12-mediated signaling events
|
|
IL2 signaling events mediated by PI3K
|
|
IL2 signaling events mediated by STAT5
|
|
IL2-mediated signaling events
|
|
IL23-mediated signaling events
|
|
IL27-mediated signaling events
|
|
IL3-mediated signaling events
|
|
IL4-mediated signaling events
|
|
IL5-mediated signaling events
|
|
IL6-mediated signaling events
|
|
IL8- and CXCR1-mediated signaling events
|
|
IL8- and CXCR2-mediated signaling events
|
|
IL8-mediated signaling events
|
|
Insulin Pathway
|
|
Insulin-mediated glucose transport
|
|
Integrin family cell surface interactions
|
|
Integrin-linked kinase signaling
|
|
Integrins in angiogenesis
|
|
Internalization of ErbB1
|
|
JNK signaling in the CD4+ TCR pathway
|
|
Lissencephaly gene (LIS1) in neuronal migration and development
|
|
LKB1 signaling events
|
|
LPA receptor mediated events
|
|
LPA4-mediated signaling events
|
|
mTOR signaling pathway
|
mTOR signaling pathway regulates cellular processes such as translation, ribosome biogenesis, cell growth and autophagy and is regulated or responds to growth factors, energy metabolites and/or levels of nutrients.
|
N-cadherin signaling events
|
|
Nectin adhesion pathway
|
|
Nephrin/Neph1 signaling in the kidney podocyte
|
|
Netrin-mediated signaling events
|
|
Neurotrophic factor-mediated Trk receptor signaling
|
|
Noncanonical Wnt signaling pathway
|
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin.
|
Nongenotropic Androgen signaling
|
|
Notch signaling pathway
|
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
Notch-mediated HES/HEY network
|
|
Osteopontin-mediated events
|
|
p38 MAPK signaling pathway
|
A SAPK MAPK pathway that plays an important role in inflammation and may be involved in several forms of cancer.
|
p38 signaling mediated by MAPKAP kinases
|
|
p53 pathway
|
|
p73 transcription factor network
|
|
p75(NTR)-mediated signaling
|
|
PAR1-mediated thrombin signaling events
|
|
PAR4-mediated thrombin signaling events
|
|
PDGF receptor signaling network
|
|
PDGFR-alpha signaling pathway
|
|
PDGFR-beta signaling pathway
|
A series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
Plasma membrane estrogen receptor signaling
|
|
Plexin-D1 Signaling
|
|
PLK1 signaling events
|
|
PLK2 and PLK4 events
|
|
PLK3 signaling events
|
|
Polo-like kinase signaling events in the cell cycle
|
|
Posttranslational regulation of adherens junction stability and dissassembly
|
|
Presenilin action in Notch and Wnt signaling
|
|
Proteoglycan syndecan-mediated signaling events
|
|
RAC1 signaling pathway
|
|
Rapid glucocorticoid signaling
|
|
Ras signaling in the CD4+ TCR pathway
|
|
Reelin signaling pathway
|
Reelin signaling pathway regulates neuronal positioning and may also play a role in synaptic plasticity. The reelin gene appears to be downregulated in the schizophrenic brains but the link between the reelin pathway and the disease remains to be established.
|
Regulation of Androgen receptor activity
|
Any process that modulates the frequency, rate or extent of androgen receptor activity.
|
Regulation of CDC42 activity
|
|
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
|
|
Regulation of nuclear beta catenin signaling and target gene transcription
|
|
Regulation of nuclear SMAD2/3 signaling
|
|
Regulation of p38-alpha and p38-beta
|
|
Regulation of RAC1 activity
|
|
Regulation of Ras family activation
|
|
Regulation of retinoblastoma protein
|
|
Regulation of RhoA activity
|
|
Regulation of Telomerase
|
|
Retinoic acid receptors-mediated signaling
|
|
RhoA signaling pathway
|
|
Role of Calcineurin-dependent NFAT signaling in lymphocytes
|
|
RXR and RAR heterodimerization with other nuclear receptor
|
|
S1P1 pathway
|
|
S1P2 pathway
|
|
S1P3 pathway
|
|
S1P4 pathway
|
|
S1P5 pathway
|
|
SHP2 signaling
|
|
Signaling by Aurora kinases
|
|
Signaling events mediated by focal adhesion kinase
|
|
Signaling events mediated by HDAC Class I
|
|
Signaling events mediated by HDAC Class II
|
|
Signaling events mediated by HDAC Class III
|
|
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
|
Signaling events mediated by PRL
|
|
Signaling events mediated by PTP1B
|
|
Signaling events mediated by Stem cell factor receptor (c-Kit)
|
|
Signaling events mediated by TCPTP
|
|
Signaling events mediated by the Hedgehog family
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
Signaling events regulated by Ret tyrosine kinase
|
|
Signaling mediated by p38-alpha and p38-beta
|
|
Signaling mediated by p38-gamma and p38-delta
|
|
Sphingosine 1-phosphate (S1P) pathway
|
|
Stabilization and expansion of the E-cadherin adherens junction
|
|
Sumoylation by RanBP2 regulates transcriptional repression
|
|
Syndecan-1-mediated signaling events
|
|
Syndecan-2-mediated signaling events
|
|
Syndecan-3-mediated signaling events
|
|
Syndecan-4-mediated signaling events
|
|
TCR signaling in naïve CD4+ T cells
|
|
TCR signaling in naïve CD8+ T cells
|
|
TGF-beta receptor signaling
|
|
Thrombin/protease-activated receptor (PAR) pathway
|
|
Thromboxane A2 receptor signaling
|
|
TNF receptor signaling pathway
|
|
TRAIL signaling pathway
|
|
Trk receptor signaling mediated by PI3K and PLC-gamma
|
|
Trk receptor signaling mediated by the MAPK pathway
|
|
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
|
|
Validated nuclear estrogen receptor alpha network
|
|
Validated nuclear estrogen receptor beta network
|
|
Validated targets of C-MYC transcriptional activation
|
|
Validated targets of C-MYC transcriptional repression
|
|
Validated transcriptional targets of AP1 family members Fra1 and Fra2
|
|
Validated transcriptional targets of deltaNp63 isoforms
|
|
Validated transcriptional targets of TAp63 isoforms
|
|
VEGF and VEGFR signaling network
|
|
VEGFR1 specific signals
|
|
VEGFR3 signaling in lymphatic endothelium
|
|
Visual signal transduction: Cones
|
|
Visual signal transduction: Rods
|
|
Wnt signaling network
|
|