267 sets of genes associated with synaptic terms from the SynGO Synaptic Gene Annotations dataset.
| Gene Set |
Description |
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presynapse
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presynaptic endocytosis
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presynaptic modulation of chemical synaptic transmission
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integral component of presynaptic membrane
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anchored component of postsynaptic recycling endosome membrane
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anchored component of postsynaptic density membrane
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regulation of postsynapse organization
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metabolism
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disease cluster belonging to disease group metabolic
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integral component of postsynaptic membrane
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regulation of retrograde trans-synaptic signaling by endocanabinoid
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postsynaptic density
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The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases. The postsynaptic density may be part of a neuron or a muscle cell or a glial cell.
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postsynapse to nucleus signaling pathway
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presynaptic actin cytoskeleton organization
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synaptic vesicle clustering
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The process that results in grouping synaptic vesicles, prior to release, at a specialized patch of the presynaptic membrane referred to as the active zone.
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postsynapse organization
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postsynaptic actin cytoskeleton
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postsynaptic actin cytoskeleton organization
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modification of postsynaptic actin cytoskeleton
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postsynapse
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regulation of postsynaptic specialization assembly
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synapse maturation
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The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.
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synapse
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The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
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modulation of chemical synaptic transmission
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postsynaptic density, intracellular component
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perisynaptic extracellular matrix
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neurotransmitter catabolic process
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The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.
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synaptic cleft
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The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released.
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integral component of synaptic membrane
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structural constituent of postsynaptic actin cytoskeleton
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regulation of synaptic vesicle endocytosis
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Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis.
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presynaptic actin cytoskeleton
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structural constituent of postsynapse
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postsynaptic density membrane
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regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
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protein catabolic process at postsynapse
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integral component of postsynaptic density membrane
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neurotransmitter receptor localization to postsynaptic specialization membrane
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neuronal dense core vesicle lumen
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synapse assembly
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The aggregation, arrangement and bonding together of a set of components to form a synapse.
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regulation of synapse disassembly
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regulation of synapse maturation
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Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.
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synapse organization
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A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
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maintenance of postsynaptic specialization structure
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regulation of presynaptic cytosolic calcium levels
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integral component of presynaptic active zone membrane
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G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
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neuronal dense core vesicle
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postsynaptic specialization organization
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regulation of postsynapse assembly
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presynaptic active zone membrane
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The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters.
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postsynaptic endosome
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regulation of modification of postsynaptic structure
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regulation of postsynaptic membrane neurotransmitter receptor levels
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extracellular matrix of synaptic cleft
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regulation of synapse organization
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Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
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postsynaptic specialization, intracellular component
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regulation of postsynaptic neurotransmitter receptor endocytosis
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extrinsic component of postsynaptic density membrane
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regulation of postsynaptic neurotransmitter receptor activity
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postsynaptic cytosol
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trans-synaptic signaling by neuropeptide
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regulation of modification of postsynaptic actin cytoskeleton
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extrinsic component of synaptic vesicle membrane
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postsynaptic endocytic zone
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synaptic vesicle endocytosis
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An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release.
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presynaptic endocytic zone
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extrinsic component of presynaptic endocytic zone membrane
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presynaptic cytosol
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postsynaptic process involved in chemical synaptic transmission
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regulation of postsynaptic membrane potential
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Any process that modulates the establishment or extent of the postsynaptic membrane potential, which is generated by changes in the membrane potential of the post synaptic neuron that receives information at a synapse. The presynaptic neuron releases neurotransmitters into the synaptic cleft which bind to receptors on the postsynaptic neuron. After being bound by the neurotransmitters, these receptors can open or close an ion channel, allowing ions to enter or leave the cell and therefore altering the membrane potential of the postsynaptic neuron.
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synaptic vesicle membrane
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The lipid bilayer surrounding a synaptic vesicle.
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postsynaptic endosome membrane
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synaptic membrane
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A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
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synaptic vesicle
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A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
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synaptic vesicle budding from endosome
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postsynaptic neurotransmitter receptor endocytosis
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presynaptic endosome
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neurotransmitter receptor transport, postsynaptic endosome to lysosome
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postsynaptic recycling endosome
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spine apparatus
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A specialization of the endomembrane system found in some classes of neuron spines consisting of two or more closely apposed lamellae with interspersed dense material.
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regulation of presynapse assembly
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presynaptic active zone
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A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, synaptic vesicles, and a specialized cortical cytoskeletal matrix.
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maintenance of synapse structure
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maintenance of postsynaptic density structure
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regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
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modification of postsynaptic structure
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regulation of synaptic vesicle cycle
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postsynaptic specialization
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regulation of neurotransmitter uptake
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Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell.
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regulation of anterograde synaptic vesicle transport
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postsynaptic signaling pathway
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axonal transport
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postsynaptic modulation of chemical synaptic transmission
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synaptic vesicle cycle
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regulation of protein catabolic process at synapse, modulating synaptic transmission
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presynaptic membrane
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A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
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ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of postsynaptic cytosolic calcium levels
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ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels
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synaptic vesicle proton loading
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integral component of synaptic vesicle membrane
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The component of the synaptic vesicle membrane consisting of gene products and protein complexes that have some part that penetrates at least one leaflet of the membrane bilayer. This component includes gene products that are buried in the bilayer with no exposure outside the bilayer.
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trans-synaptic signaling by BDNF, modulating synaptic transmission
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regulation of synaptic vesicle priming
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Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.
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presynaptic active zone cytoplasmic component
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structural constituent of active zone
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extrinsic component of presynaptic membrane
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extrinsic component of postsynaptic membrane
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postsynaptic density assembly
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The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse.
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voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
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regulation of calcium-dependent activation of synaptic vesicle fusion
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regulation of synaptic vesicle exocytosis
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Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
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anchored component of postsynaptic membrane
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anchored component of presynaptic active zone membrane
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regulation of presynapse organization
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postsynaptic neurotransmitter receptor diffusion trapping
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presynapse assembly
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synapse adhesion between pre- and post-synapse
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retrograde trans-synaptic signaling by trans-synaptic protein complex
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presynaptic dense core vesicle exocytosis
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extrinsic component of neuronal dense core vesicle membrane
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synaptic vesicle priming
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The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.
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calcium ion binding involved in regulation of presynaptic cytosolic calcium levels
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calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels
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postsynaptic ER
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regulation of synaptic vesicle docking
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regulation of postsynaptic density assembly
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regulation of presynaptic membrane potential
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regulation protein catabolic process at postsynapse
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trans-synaptic signaling, modulating synaptic transmission
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synaptic signaling via neuropeptide
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regulation of protein catabolic process at postsynapse, modulating synaptic transmission
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integral component of postsynaptic specialization membrane
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regulation of synapse assembly
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Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
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transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
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integral component of spine apparatus membrane
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presynaptic cytoskeleton organization
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neurotransmitter receptor transport to postsynaptic membrane
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presynaptic endocytic zone membrane
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retrograde trans-synaptic signaling by endocannabinoid
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regulation of ATP metabolic process in the presynapse
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trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
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regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
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anchored component of presynaptic membrane
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regulation of translation at synapse, modulating synaptic transmission
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regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane
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regulation of synaptic vesicle fusion to presynaptic active zone membrane
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anchored component of synaptic vesicle membrane
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integral component of postsynaptic ER membrane
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postsynaptic specialization assembly
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presynapse to nucleus signaling pathway
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synaptic vesicle docking
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The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane.
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postsynaptic membrane
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A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.
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structural constituent of postsynaptic density
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synaptic vesicle endosomal processing
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regulation of translation at postsynapse, modulating synaptic transmission
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extrinsic component of postsynaptic specialization membrane
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extrinsic component of presynaptic active zone membrane
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regulation of proton loading
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presynaptic chaperone-mediated protein folding
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synaptic vesicle uncoating
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The removal of the protein coat on a synaptic vesicle.
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postsynaptic endocytosis
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postsynaptic endocytic zone membrane
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calcium-dependent activation of synaptic vesicle fusion
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transport
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The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.
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postsynaptic early endosome
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translation at postsynapse
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regulation of translation at postsynapse
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trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
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regulation of translation at presynapse, modulating synaptic transmission
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postsynaptic cytoskeleton organization
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synapse disassembly
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postsynaptic membrane assembly
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The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
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regulation of presynaptic dense core vesicle exocytosis
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anterograde axonal protein transport
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regulation of protein catabolic process at presynapse, modulating synaptic transmission
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trans-synaptic signaling
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anterograde dendritic transport
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regulation of postsynaptic cytosolic calcium levels
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G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential
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ligand-gated ion channel activity involved in regulation of presynaptic membrane potential
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neurotransmitter biosynthetic process
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The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.
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ATP metabolic process in the postsynapse
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regulation of synaptic vesicle neurotransmitter loading
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structural constituent of postsynaptic specialization
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neurotransmitter receptor transport, endosome to postsynaptic membrane
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regulation of recycling endosome localization within postsynapse
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extrinsic component of postsynaptic early endosome membrane
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G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels
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retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
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intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential
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dendritic transport of messenger ribonucleoprotein complex
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postsynaptic specialization membrane
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postsynaptic specialization of symmetric synapse
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trans-synaptic signaling by trans-synaptic complex
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structural constituent of postsynaptic intermediate filament cytoskeleton
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postsynaptic intermediate filament cytoskeleton
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regulation of postsynaptic neurotransmitter receptor diffusion trapping
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inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
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integral component of postsynaptic SER membrane
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integral component of presynaptic SER membrane
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integral component of presynaptic ER membrane
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regulation of postsynapse to nucleus signaling pathway
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voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential
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voltage-gated ion channel activity involved in regulation of presynaptic membrane potential
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anterograde dendritic transport of neurotransmitter receptor complex
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anterograde synaptic vesicle transport
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The directed movement of substances in synaptic membrane-bounded vesicles within the neuron, along the cytoskeleton, away from the neuronal cell body.
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anterograde axonal transport
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retrograde dendritic transport
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dendritic transport
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regulation of modification of synapse structure, modulating synaptic transmission
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anterograde dendritic transport of messenger ribonucleoprotein complex
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structural constituent of synapse-associated extracellular matrix
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postsynaptic Golgi apparatus
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regulation of synaptic membrane adhesion
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structural constituent of presynapse
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postsynaptic cytoskeleton
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synaptic vesicle exocytosis
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Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
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neurotransmitter receptor transport postsynaptic membrane to endosome
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postsynaptic specialization membrane of symmetric synapse
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modification of synaptic structure, modulating synaptic transmission
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establishment of endoplasmic reticulum localization to postsynapse
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postsynaptic SER
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postsynaptic recycling endosome membrane
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synaptic vesicle recycling via endosome
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neurotransmitter receptor transport, endosome to plasma membrane
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presynaptic SER membrane
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presynaptic intermediate filament cytoskeleton
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anterograde axonal transport of neurotransmitter receptor complex
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synaptic signaling by nitric oxide
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extrinsic component of synaptic membrane
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synaptic vesicle lumen
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The volume enclosed by the synaptic vesicle membrane.
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extrasynaptic space
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regulation protein catabolic process at presynapse
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structural constituent of presynaptic actin cytoskeleton
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synaptic target recognition
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The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses.
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integral component of neuronal dense core vesicle membrane
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protein catabolic process, modulating synaptic transmission
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regulation of synaptic signaling by nitric oxide
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translation at presynapse
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presynaptic ribosome
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postsynaptic ribosome
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exocytic insertion of neurotransmitter receptor to postsynaptic membrane
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protein catabolic process at presynapse
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postsynaptic septin cytoskeleton
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presynaptic signaling pathway
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synaptic vesicle neurotransmitter loading
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neurotransmitter reuptake
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neurotransmitter uptake
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The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. It does not occur during cholinergic synaptic transmission. Instead, acetylcholine is enzymatically degraded in the synaptic cleft.
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regulation of synaptic vesicle budding from presynaptic endocytic zone membrane
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zinc ion import into synaptic vesicle
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calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion levels
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regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission
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extrinsic component of postsynaptic endosome membrane
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postsynaptic spectrin-associated cytoskeleton
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synaptic vesicle to endosome fusion
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Fusion of a synaptic vesicle with the membrane of an endosome.
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integral component of postsynaptic recycling endosome membrane
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synaptic vesicle fusion to presynaptic active zone membrane
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regulation of postsynaptic dense core vesicle exocytosis
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postsynaptic dense core vesicle exocytosis
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maintenance of alignment of postsynaptic density and presynaptic active zone
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postsynaptic spectrin-associated cytoskeleton organization
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RNA polyadenylation at postsynapse
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axonal transport of messenger ribonucleoprotein complex
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integral component of presynaptic endosome membrane
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presynaptic cytoskeleton
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presynaptic ER
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dendritic transport of mitochondrion
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trans-synaptic signalling via exosome
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