SynGO Synaptic Gene Annotations Dataset

Description curated annotations of genes with synaptic terms
Measurement association by literature curation
Association gene-biological terms associations from curated gene annotations
Category structural or functional annotations
Resource SynGO
Citation(s)
Last Updated 2024 Mar 04
Stats
  1. 1593 genes
  2. 267 biological terms
  3. 3906 gene-biological term associations

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biological term Gene Sets

267 sets of genes associated with synaptic terms from the SynGO Synaptic Gene Annotations dataset.

Gene Set Description
anchored component of postsynaptic density membrane
anchored component of postsynaptic membrane
anchored component of postsynaptic recycling endosome membrane
anchored component of presynaptic active zone membrane
anchored component of presynaptic membrane
anchored component of synaptic vesicle membrane
anterograde axonal protein transport
anterograde axonal transport
anterograde axonal transport of neurotransmitter receptor complex
anterograde dendritic transport
anterograde dendritic transport of messenger ribonucleoprotein complex
anterograde dendritic transport of neurotransmitter receptor complex
anterograde synaptic vesicle transport The directed movement of substances in synaptic membrane-bounded vesicles within the neuron, along the cytoskeleton, away from the neuronal cell body.
ATP metabolic process in the postsynapse
ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of postsynaptic cytosolic calcium levels
ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels
axonal transport
axonal transport of messenger ribonucleoprotein complex
calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels
calcium ion binding involved in regulation of presynaptic cytosolic calcium levels
calcium-dependent activation of synaptic vesicle fusion
calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion levels
dendritic transport
dendritic transport of messenger ribonucleoprotein complex
dendritic transport of mitochondrion
establishment of endoplasmic reticulum localization to postsynapse
exocytic insertion of neurotransmitter receptor to postsynaptic membrane
extracellular matrix of synaptic cleft
extrasynaptic space
extrinsic component of neuronal dense core vesicle membrane
extrinsic component of postsynaptic density membrane
extrinsic component of postsynaptic early endosome membrane
extrinsic component of postsynaptic endosome membrane
extrinsic component of postsynaptic membrane
extrinsic component of postsynaptic specialization membrane
extrinsic component of presynaptic active zone membrane
extrinsic component of presynaptic endocytic zone membrane
extrinsic component of presynaptic membrane
extrinsic component of synaptic membrane
extrinsic component of synaptic vesicle membrane
G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential
G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels
inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
integral component of neuronal dense core vesicle membrane
integral component of postsynaptic density membrane
integral component of postsynaptic ER membrane
integral component of postsynaptic membrane
integral component of postsynaptic recycling endosome membrane
integral component of postsynaptic SER membrane
integral component of postsynaptic specialization membrane
integral component of presynaptic active zone membrane
integral component of presynaptic endosome membrane
integral component of presynaptic ER membrane
integral component of presynaptic membrane
integral component of presynaptic SER membrane
integral component of spine apparatus membrane
integral component of synaptic membrane
integral component of synaptic vesicle membrane The component of the synaptic vesicle membrane consisting of gene products and protein complexes that have some part that penetrates at least one leaflet of the membrane bilayer. This component includes gene products that are buried in the bilayer with no exposure outside the bilayer.
intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential
ligand-gated ion channel activity involved in regulation of presynaptic membrane potential
maintenance of alignment of postsynaptic density and presynaptic active zone
maintenance of postsynaptic density structure
maintenance of postsynaptic specialization structure
maintenance of synapse structure
metabolism disease cluster belonging to disease group metabolic
modification of postsynaptic actin cytoskeleton
modification of postsynaptic structure
modification of synaptic structure, modulating synaptic transmission
modulation of chemical synaptic transmission
neuronal dense core vesicle
neuronal dense core vesicle lumen
neurotransmitter biosynthetic process The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.
neurotransmitter catabolic process The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.
neurotransmitter receptor localization to postsynaptic specialization membrane
neurotransmitter receptor transport postsynaptic membrane to endosome
neurotransmitter receptor transport to postsynaptic membrane
neurotransmitter receptor transport, endosome to plasma membrane
neurotransmitter receptor transport, endosome to postsynaptic membrane
neurotransmitter receptor transport, postsynaptic endosome to lysosome
neurotransmitter reuptake
neurotransmitter uptake The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. It does not occur during cholinergic synaptic transmission. Instead, acetylcholine is enzymatically degraded in the synaptic cleft.
perisynaptic extracellular matrix
postsynapse
postsynapse organization
postsynapse to nucleus signaling pathway
postsynaptic actin cytoskeleton
postsynaptic actin cytoskeleton organization
postsynaptic cytoskeleton
postsynaptic cytoskeleton organization
postsynaptic cytosol
postsynaptic dense core vesicle exocytosis
postsynaptic density The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases. The postsynaptic density may be part of a neuron or a muscle cell or a glial cell.
postsynaptic density assembly The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse.
postsynaptic density membrane
postsynaptic density, intracellular component
postsynaptic early endosome
postsynaptic endocytic zone
postsynaptic endocytic zone membrane
postsynaptic endocytosis
postsynaptic endosome
postsynaptic endosome membrane
postsynaptic ER
postsynaptic Golgi apparatus
postsynaptic intermediate filament cytoskeleton
postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.
postsynaptic membrane assembly The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
postsynaptic modulation of chemical synaptic transmission
postsynaptic neurotransmitter receptor diffusion trapping
postsynaptic neurotransmitter receptor endocytosis
postsynaptic process involved in chemical synaptic transmission
postsynaptic recycling endosome
postsynaptic recycling endosome membrane
postsynaptic ribosome
postsynaptic septin cytoskeleton
postsynaptic SER
postsynaptic signaling pathway
postsynaptic specialization
postsynaptic specialization assembly
postsynaptic specialization membrane
postsynaptic specialization membrane of symmetric synapse
postsynaptic specialization of symmetric synapse
postsynaptic specialization organization
postsynaptic specialization, intracellular component
postsynaptic spectrin-associated cytoskeleton
postsynaptic spectrin-associated cytoskeleton organization
presynapse
presynapse assembly
presynapse to nucleus signaling pathway
presynaptic actin cytoskeleton
presynaptic actin cytoskeleton organization
presynaptic active zone A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, synaptic vesicles, and a specialized cortical cytoskeletal matrix.
presynaptic active zone cytoplasmic component
presynaptic active zone membrane The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters.
presynaptic chaperone-mediated protein folding
presynaptic cytoskeleton
presynaptic cytoskeleton organization
presynaptic cytosol
presynaptic dense core vesicle exocytosis
presynaptic endocytic zone
presynaptic endocytic zone membrane
presynaptic endocytosis
presynaptic endosome
presynaptic ER
presynaptic intermediate filament cytoskeleton
presynaptic membrane A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
presynaptic modulation of chemical synaptic transmission
presynaptic ribosome
presynaptic SER membrane
presynaptic signaling pathway
protein catabolic process at postsynapse
protein catabolic process at presynapse
protein catabolic process, modulating synaptic transmission
regulation of anterograde synaptic vesicle transport
regulation of ATP metabolic process in the presynapse
regulation of calcium-dependent activation of synaptic vesicle fusion
regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane
regulation of modification of postsynaptic actin cytoskeleton
regulation of modification of postsynaptic structure
regulation of modification of synapse structure, modulating synaptic transmission
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
regulation of neurotransmitter uptake Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell.
regulation of postsynapse assembly
regulation of postsynapse organization
regulation of postsynapse to nucleus signaling pathway
regulation of postsynaptic cytosolic calcium levels
regulation of postsynaptic dense core vesicle exocytosis
regulation of postsynaptic density assembly
regulation of postsynaptic membrane neurotransmitter receptor levels
regulation of postsynaptic membrane potential Any process that modulates the establishment or extent of the postsynaptic membrane potential, which is generated by changes in the membrane potential of the post synaptic neuron that receives information at a synapse. The presynaptic neuron releases neurotransmitters into the synaptic cleft which bind to receptors on the postsynaptic neuron. After being bound by the neurotransmitters, these receptors can open or close an ion channel, allowing ions to enter or leave the cell and therefore altering the membrane potential of the postsynaptic neuron.
regulation of postsynaptic neurotransmitter receptor activity
regulation of postsynaptic neurotransmitter receptor diffusion trapping
regulation of postsynaptic neurotransmitter receptor endocytosis
regulation of postsynaptic specialization assembly
regulation of presynapse assembly
regulation of presynapse organization
regulation of presynaptic cytosolic calcium levels
regulation of presynaptic dense core vesicle exocytosis
regulation of presynaptic membrane potential
regulation of protein catabolic process at postsynapse, modulating synaptic transmission
regulation of protein catabolic process at presynapse, modulating synaptic transmission
regulation of protein catabolic process at synapse, modulating synaptic transmission
regulation of proton loading
regulation of recycling endosome localization within postsynapse
regulation of retrograde trans-synaptic signaling by endocanabinoid
regulation of synapse assembly Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
regulation of synapse disassembly
regulation of synapse maturation Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.
regulation of synapse organization Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
regulation of synaptic membrane adhesion
regulation of synaptic signaling by nitric oxide
regulation of synaptic vesicle budding from presynaptic endocytic zone membrane
regulation of synaptic vesicle cycle
regulation of synaptic vesicle docking
regulation of synaptic vesicle endocytosis Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis.
regulation of synaptic vesicle exocytosis Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
regulation of synaptic vesicle fusion to presynaptic active zone membrane
regulation of synaptic vesicle neurotransmitter loading
regulation of synaptic vesicle priming Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.
regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission
regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
regulation of translation at postsynapse
regulation of translation at postsynapse, modulating synaptic transmission
regulation of translation at presynapse, modulating synaptic transmission
regulation of translation at synapse, modulating synaptic transmission
regulation protein catabolic process at postsynapse
regulation protein catabolic process at presynapse
retrograde dendritic transport
retrograde trans-synaptic signaling by endocannabinoid
retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
retrograde trans-synaptic signaling by trans-synaptic protein complex
RNA polyadenylation at postsynapse
spine apparatus A specialization of the endomembrane system found in some classes of neuron spines consisting of two or more closely apposed lamellae with interspersed dense material.
structural constituent of active zone
structural constituent of postsynapse
structural constituent of postsynaptic actin cytoskeleton
structural constituent of postsynaptic density
structural constituent of postsynaptic intermediate filament cytoskeleton
structural constituent of postsynaptic specialization
structural constituent of presynapse
structural constituent of presynaptic actin cytoskeleton
structural constituent of synapse-associated extracellular matrix
synapse The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
synapse adhesion between pre- and post-synapse
synapse assembly The aggregation, arrangement and bonding together of a set of components to form a synapse.
synapse disassembly
synapse maturation The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.
synapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
synaptic cleft The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released.
synaptic membrane A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
synaptic signaling by nitric oxide
synaptic signaling via neuropeptide
synaptic target recognition The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses.
synaptic vesicle A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
synaptic vesicle budding from endosome
synaptic vesicle clustering The process that results in grouping synaptic vesicles, prior to release, at a specialized patch of the presynaptic membrane referred to as the active zone.
synaptic vesicle cycle
synaptic vesicle docking The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane.
synaptic vesicle endocytosis An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release.
synaptic vesicle endosomal processing
synaptic vesicle exocytosis Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
synaptic vesicle fusion to presynaptic active zone membrane
synaptic vesicle lumen The volume enclosed by the synaptic vesicle membrane.
synaptic vesicle membrane The lipid bilayer surrounding a synaptic vesicle.
synaptic vesicle neurotransmitter loading
synaptic vesicle priming The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.
synaptic vesicle proton loading
synaptic vesicle recycling via endosome
synaptic vesicle to endosome fusion Fusion of a synaptic vesicle with the membrane of an endosome.
synaptic vesicle uncoating The removal of the protein coat on a synaptic vesicle.
trans-synaptic signaling
trans-synaptic signaling by BDNF, modulating synaptic transmission
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
trans-synaptic signaling by neuropeptide
trans-synaptic signaling by trans-synaptic complex
trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
trans-synaptic signaling, modulating synaptic transmission
trans-synaptic signalling via exosome
translation at postsynapse
translation at presynapse
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential
voltage-gated ion channel activity involved in regulation of presynaptic membrane potential
zinc ion import into synaptic vesicle