267 sets of genes associated with synaptic terms from the SynGO Synaptic Gene Annotations dataset.
| Gene Set |
Description |
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anchored component of postsynaptic density membrane
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anchored component of postsynaptic membrane
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anchored component of postsynaptic recycling endosome membrane
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anchored component of presynaptic active zone membrane
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anchored component of presynaptic membrane
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anchored component of synaptic vesicle membrane
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anterograde axonal protein transport
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anterograde axonal transport
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anterograde axonal transport of neurotransmitter receptor complex
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anterograde dendritic transport
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anterograde dendritic transport of messenger ribonucleoprotein complex
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anterograde dendritic transport of neurotransmitter receptor complex
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anterograde synaptic vesicle transport
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The directed movement of substances in synaptic membrane-bounded vesicles within the neuron, along the cytoskeleton, away from the neuronal cell body.
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ATP metabolic process in the postsynapse
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ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of postsynaptic cytosolic calcium levels
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ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels
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axonal transport
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axonal transport of messenger ribonucleoprotein complex
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calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels
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calcium ion binding involved in regulation of presynaptic cytosolic calcium levels
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calcium-dependent activation of synaptic vesicle fusion
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calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion levels
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dendritic transport
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dendritic transport of messenger ribonucleoprotein complex
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dendritic transport of mitochondrion
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establishment of endoplasmic reticulum localization to postsynapse
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exocytic insertion of neurotransmitter receptor to postsynaptic membrane
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extracellular matrix of synaptic cleft
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extrasynaptic space
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extrinsic component of neuronal dense core vesicle membrane
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extrinsic component of postsynaptic density membrane
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extrinsic component of postsynaptic early endosome membrane
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extrinsic component of postsynaptic endosome membrane
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extrinsic component of postsynaptic membrane
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extrinsic component of postsynaptic specialization membrane
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extrinsic component of presynaptic active zone membrane
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extrinsic component of presynaptic endocytic zone membrane
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extrinsic component of presynaptic membrane
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extrinsic component of synaptic membrane
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extrinsic component of synaptic vesicle membrane
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G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
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G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential
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G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels
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inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
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integral component of neuronal dense core vesicle membrane
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integral component of postsynaptic density membrane
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integral component of postsynaptic ER membrane
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integral component of postsynaptic membrane
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integral component of postsynaptic recycling endosome membrane
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integral component of postsynaptic SER membrane
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integral component of postsynaptic specialization membrane
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integral component of presynaptic active zone membrane
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integral component of presynaptic endosome membrane
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integral component of presynaptic ER membrane
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integral component of presynaptic membrane
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integral component of presynaptic SER membrane
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integral component of spine apparatus membrane
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integral component of synaptic membrane
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integral component of synaptic vesicle membrane
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The component of the synaptic vesicle membrane consisting of gene products and protein complexes that have some part that penetrates at least one leaflet of the membrane bilayer. This component includes gene products that are buried in the bilayer with no exposure outside the bilayer.
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intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential
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ligand-gated ion channel activity involved in regulation of presynaptic membrane potential
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maintenance of alignment of postsynaptic density and presynaptic active zone
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maintenance of postsynaptic density structure
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maintenance of postsynaptic specialization structure
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maintenance of synapse structure
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metabolism
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disease cluster belonging to disease group metabolic
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modification of postsynaptic actin cytoskeleton
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modification of postsynaptic structure
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modification of synaptic structure, modulating synaptic transmission
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modulation of chemical synaptic transmission
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neuronal dense core vesicle
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neuronal dense core vesicle lumen
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neurotransmitter biosynthetic process
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The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.
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neurotransmitter catabolic process
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The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.
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neurotransmitter receptor localization to postsynaptic specialization membrane
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neurotransmitter receptor transport postsynaptic membrane to endosome
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neurotransmitter receptor transport to postsynaptic membrane
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neurotransmitter receptor transport, endosome to plasma membrane
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neurotransmitter receptor transport, endosome to postsynaptic membrane
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neurotransmitter receptor transport, postsynaptic endosome to lysosome
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neurotransmitter reuptake
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neurotransmitter uptake
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The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. It does not occur during cholinergic synaptic transmission. Instead, acetylcholine is enzymatically degraded in the synaptic cleft.
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perisynaptic extracellular matrix
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postsynapse
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postsynapse organization
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postsynapse to nucleus signaling pathway
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postsynaptic actin cytoskeleton
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postsynaptic actin cytoskeleton organization
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postsynaptic cytoskeleton
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postsynaptic cytoskeleton organization
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postsynaptic cytosol
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postsynaptic dense core vesicle exocytosis
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postsynaptic density
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The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases. The postsynaptic density may be part of a neuron or a muscle cell or a glial cell.
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postsynaptic density assembly
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The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse.
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postsynaptic density membrane
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postsynaptic density, intracellular component
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postsynaptic early endosome
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postsynaptic endocytic zone
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postsynaptic endocytic zone membrane
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postsynaptic endocytosis
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postsynaptic endosome
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postsynaptic endosome membrane
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postsynaptic ER
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postsynaptic Golgi apparatus
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postsynaptic intermediate filament cytoskeleton
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postsynaptic membrane
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A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.
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postsynaptic membrane assembly
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The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
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postsynaptic modulation of chemical synaptic transmission
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postsynaptic neurotransmitter receptor diffusion trapping
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postsynaptic neurotransmitter receptor endocytosis
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postsynaptic process involved in chemical synaptic transmission
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postsynaptic recycling endosome
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postsynaptic recycling endosome membrane
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postsynaptic ribosome
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postsynaptic septin cytoskeleton
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postsynaptic SER
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postsynaptic signaling pathway
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postsynaptic specialization
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postsynaptic specialization assembly
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postsynaptic specialization membrane
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postsynaptic specialization membrane of symmetric synapse
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postsynaptic specialization of symmetric synapse
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postsynaptic specialization organization
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postsynaptic specialization, intracellular component
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postsynaptic spectrin-associated cytoskeleton
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postsynaptic spectrin-associated cytoskeleton organization
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presynapse
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presynapse assembly
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presynapse to nucleus signaling pathway
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presynaptic actin cytoskeleton
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presynaptic actin cytoskeleton organization
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presynaptic active zone
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A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, synaptic vesicles, and a specialized cortical cytoskeletal matrix.
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presynaptic active zone cytoplasmic component
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presynaptic active zone membrane
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The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters.
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presynaptic chaperone-mediated protein folding
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presynaptic cytoskeleton
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presynaptic cytoskeleton organization
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presynaptic cytosol
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presynaptic dense core vesicle exocytosis
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presynaptic endocytic zone
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presynaptic endocytic zone membrane
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presynaptic endocytosis
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presynaptic endosome
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presynaptic ER
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presynaptic intermediate filament cytoskeleton
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presynaptic membrane
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A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
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presynaptic modulation of chemical synaptic transmission
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presynaptic ribosome
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presynaptic SER membrane
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presynaptic signaling pathway
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protein catabolic process at postsynapse
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protein catabolic process at presynapse
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protein catabolic process, modulating synaptic transmission
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regulation of anterograde synaptic vesicle transport
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regulation of ATP metabolic process in the presynapse
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regulation of calcium-dependent activation of synaptic vesicle fusion
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regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane
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regulation of modification of postsynaptic actin cytoskeleton
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regulation of modification of postsynaptic structure
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regulation of modification of synapse structure, modulating synaptic transmission
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regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
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regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
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regulation of neurotransmitter uptake
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Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell.
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regulation of postsynapse assembly
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regulation of postsynapse organization
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regulation of postsynapse to nucleus signaling pathway
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regulation of postsynaptic cytosolic calcium levels
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regulation of postsynaptic dense core vesicle exocytosis
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regulation of postsynaptic density assembly
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regulation of postsynaptic membrane neurotransmitter receptor levels
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regulation of postsynaptic membrane potential
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Any process that modulates the establishment or extent of the postsynaptic membrane potential, which is generated by changes in the membrane potential of the post synaptic neuron that receives information at a synapse. The presynaptic neuron releases neurotransmitters into the synaptic cleft which bind to receptors on the postsynaptic neuron. After being bound by the neurotransmitters, these receptors can open or close an ion channel, allowing ions to enter or leave the cell and therefore altering the membrane potential of the postsynaptic neuron.
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regulation of postsynaptic neurotransmitter receptor activity
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regulation of postsynaptic neurotransmitter receptor diffusion trapping
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regulation of postsynaptic neurotransmitter receptor endocytosis
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regulation of postsynaptic specialization assembly
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regulation of presynapse assembly
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regulation of presynapse organization
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regulation of presynaptic cytosolic calcium levels
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regulation of presynaptic dense core vesicle exocytosis
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regulation of presynaptic membrane potential
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regulation of protein catabolic process at postsynapse, modulating synaptic transmission
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regulation of protein catabolic process at presynapse, modulating synaptic transmission
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regulation of protein catabolic process at synapse, modulating synaptic transmission
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regulation of proton loading
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regulation of recycling endosome localization within postsynapse
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regulation of retrograde trans-synaptic signaling by endocanabinoid
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regulation of synapse assembly
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Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
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regulation of synapse disassembly
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regulation of synapse maturation
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Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.
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regulation of synapse organization
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Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
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regulation of synaptic membrane adhesion
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regulation of synaptic signaling by nitric oxide
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regulation of synaptic vesicle budding from presynaptic endocytic zone membrane
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regulation of synaptic vesicle cycle
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regulation of synaptic vesicle docking
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regulation of synaptic vesicle endocytosis
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Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis.
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regulation of synaptic vesicle exocytosis
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Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
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regulation of synaptic vesicle fusion to presynaptic active zone membrane
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regulation of synaptic vesicle neurotransmitter loading
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regulation of synaptic vesicle priming
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Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.
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regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission
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regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
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regulation of translation at postsynapse
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regulation of translation at postsynapse, modulating synaptic transmission
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regulation of translation at presynapse, modulating synaptic transmission
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regulation of translation at synapse, modulating synaptic transmission
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regulation protein catabolic process at postsynapse
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regulation protein catabolic process at presynapse
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retrograde dendritic transport
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retrograde trans-synaptic signaling by endocannabinoid
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retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
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retrograde trans-synaptic signaling by trans-synaptic protein complex
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RNA polyadenylation at postsynapse
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spine apparatus
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A specialization of the endomembrane system found in some classes of neuron spines consisting of two or more closely apposed lamellae with interspersed dense material.
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structural constituent of active zone
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structural constituent of postsynapse
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structural constituent of postsynaptic actin cytoskeleton
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structural constituent of postsynaptic density
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structural constituent of postsynaptic intermediate filament cytoskeleton
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structural constituent of postsynaptic specialization
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structural constituent of presynapse
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structural constituent of presynaptic actin cytoskeleton
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structural constituent of synapse-associated extracellular matrix
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synapse
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The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
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synapse adhesion between pre- and post-synapse
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synapse assembly
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The aggregation, arrangement and bonding together of a set of components to form a synapse.
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synapse disassembly
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synapse maturation
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The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.
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synapse organization
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A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
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synaptic cleft
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The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released.
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synaptic membrane
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A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
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synaptic signaling by nitric oxide
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synaptic signaling via neuropeptide
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synaptic target recognition
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The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses.
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synaptic vesicle
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A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
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synaptic vesicle budding from endosome
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synaptic vesicle clustering
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The process that results in grouping synaptic vesicles, prior to release, at a specialized patch of the presynaptic membrane referred to as the active zone.
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synaptic vesicle cycle
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synaptic vesicle docking
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The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane.
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synaptic vesicle endocytosis
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An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release.
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synaptic vesicle endosomal processing
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synaptic vesicle exocytosis
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Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
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synaptic vesicle fusion to presynaptic active zone membrane
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synaptic vesicle lumen
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The volume enclosed by the synaptic vesicle membrane.
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synaptic vesicle membrane
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The lipid bilayer surrounding a synaptic vesicle.
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synaptic vesicle neurotransmitter loading
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synaptic vesicle priming
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The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.
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synaptic vesicle proton loading
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synaptic vesicle recycling via endosome
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synaptic vesicle to endosome fusion
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Fusion of a synaptic vesicle with the membrane of an endosome.
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synaptic vesicle uncoating
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The removal of the protein coat on a synaptic vesicle.
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trans-synaptic signaling
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trans-synaptic signaling by BDNF, modulating synaptic transmission
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trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
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trans-synaptic signaling by neuropeptide
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trans-synaptic signaling by trans-synaptic complex
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trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
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trans-synaptic signaling, modulating synaptic transmission
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trans-synaptic signalling via exosome
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translation at postsynapse
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translation at presynapse
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transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
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transport
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The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.
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voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
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voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential
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voltage-gated ion channel activity involved in regulation of presynaptic membrane potential
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zinc ion import into synaptic vesicle
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