880 sets of proteins participating in pathways from the WikiPathways Pathways 2024 dataset.
| Gene Set |
Description |
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Glutathione metabolism
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Alanine and aspartate metabolism
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Translation factors
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Electron transport chain OXPHOS system in mitochondria
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GPCRs other
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Osteoclast signaling
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IL5 signaling
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Matrix metalloproteinases
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disease cluster belonging to disease group cardiovascular
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Pentose phosphate metabolism
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Phase I biotransformations non P450
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Androgen receptor signaling
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AMP activated protein kinase signaling
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Sphingolipid pathway
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Ganglio sphingolipid metabolism
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Bone morphogenic protein signaling and regulation
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Fatty acid beta oxidation
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Nucleotide binding oligomerization domain NOD pathway
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Osteopontin signaling
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Influenza A virus infection
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Serotonin transporter activity
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Target of rapamycin signaling
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Glycine metabolism
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Selenium micronutrient network
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Physiological and pathological hypertrophy of the heart
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miRNA regulation of DNA damage response
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Vitamin D metabolism
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Vitamin B12 metabolism
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Angiogenesis
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Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
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Energy metabolism
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MicroRNAs in cardiomyocyte hypertrophy
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miRNAs involved in DNA damage response
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Transcription factors regulate miRNAs related to cardiac hypertrophy
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Type II diabetes mellitus
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A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.|A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.
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Folate alcohol and cancer pathway hypotheses
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Heart development
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The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
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Nicotine metabolism in liver cells
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Fluoropyrimidine activity
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Nicotine effect on dopaminergic neurons
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Nicotine effect on chromaffin cells
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Codeine and morphine metabolism
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Eicosanoid synthesis
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Nuclear receptors
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TP53 network
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Folate metabolism
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Apoptosis modulation and signaling
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Cell cycle
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The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
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Proteasome degradation
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Integrin mediated cell adhesion
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Homologous recombination
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Peroxisomal beta oxidation of tetracosanoyl CoA
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Cori cycle
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IL1 signaling
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Cholesterol biosynthesis pathway
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Integrated cancer pathway
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Thyroxine thyroid hormone production
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Sterol regulatory element binding proteins SREBP signaling
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SRF and miRs in smooth muscle differentiation and proliferation
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Genes targeted by miRNAs in adipocytes
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Effects of nitric oxide
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Iron metabolism in placenta
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SREBF and miR33 in cholesterol and lipid homeostasis
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RANKL RANK signaling
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Cell differentiation expanded index
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Cell differentiation index
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Thyroid stimulating hormone TSH signaling
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Leptin signaling
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Follicle stimulating hormone FSH signaling
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TNF related weak inducer of apoptosis TWEAK signaling
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Prolactin signaling
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Microtubule cytoskeleton regulation
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IL7 signaling
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Alzheimer 39 s disease and miRNA effects
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Fatty acid omega oxidation
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Neural crest differentiation
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IL17 signaling
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Type III interferon signaling
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Arrhythmogenic right ventricular cardiomyopathy
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An intrinsic cardiomyopathy that is characterized by hypokinetic areas involving the free wall of the right ventricle, with fibrofatty replacement of the right ventricular myocardium, with associated arrhythmias originating in the right ventricle.
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Endothelin pathways
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IL9 signaling
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Thymic stromal lymphopoietin TSLP signaling
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Metastatic brain tumor
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Pilocytic astrocytoma
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An astrocytoma that is characterized by cells that look like fibers when viewed under a microscope and is located_in the brain.
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Glioblastoma signaling
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Androgen receptor network in prostate cancer
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Synaptic vesicle pathway
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Pathogenic Escherichia coli infection
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Glial cell differentiation
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The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.
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Drug induction of bile acid pathway
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Irinotecan pathway
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RalA downstream regulated genes
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Deregulation of Rab and Rab effector genes in bladder cancer
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B cell receptor signaling
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TNF alpha signaling
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AGE RAGE pathway
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Allograft rejection
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IL11 signaling
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Trans sulfuration pathway
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miRNA biogenesis
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Corticotropin releasing hormone signaling
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Parkin ubiquitin proteasomal system pathway
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Adipogenesis
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Gastric cancer network 1
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Gastric cancer network 2
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Butyrate induced histone acetylation
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Histone modifications
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Parkinson 39 s disease pathway
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Oncostatin M signaling
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Brain derived neurotrophic factor BDNF signaling
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Peptide GPCRs
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Cardiac progenitor differentiation
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One carbon metabolism
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Spinal cord injury
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Quercetin and Nf kB AP 1 induced apoptosis
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Dopamine metabolism
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Alpha 6 beta 4 signaling
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Retinoblastoma gene in cancer
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Amyotrophic lateral sclerosis ALS
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TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc
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HIF1A and PPARG in cardiac hypertropthy
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Small ligand GPCRs
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NAD biosynthesis II from tryptophan
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Diclofenac metabolic pathway
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Nanomaterial induced apoptosis
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Nanoparticle triggered autophagic cell death
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Nanoparticle triggered regulated necrosis
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ATM signaling
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Trans sulfuration one carbon metabolism and related pathways
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PDGF pathway
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Glycerophospholipid biosynthetic pathway
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Colchicine metabolic pathway
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Apoptosis
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Sulindac metabolic pathway
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Polycystic kidney disease pathway
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Primary focal segmental glomerulosclerosis FSGS
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T cell receptor and co stimulatory signaling
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Aryl hydrocarbon receptor pathway
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Gastric acid production
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S1P receptor signal transduction
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Ebstein Barr virus LMP1 signaling
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Common pathways underlying drug addiction
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Interleukin 1 IL 1 structural pathway
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Aripiprazole metabolic pathway
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Nanoparticle mediated activation of receptor signaling
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Heroin metabolism
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Lidocaine metabolism
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Notch signaling
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Blood clotting cascade
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Cardiac hypertrophic response
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Selenium metabolism and selenoproteins
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exRNA mechanism of action and biogenesis
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Complement system
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Mammary gland development pathway Embryonic development Stage 1 of 4
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Mammary gland development pathway Puberty Stage 2 of 4
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Mammary gland development pathway Involution Stage 4 of 4
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Felbamate metabolism
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Mammary gland development pregnancy and lactation stage 3 of 4
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Cocaine metabolism
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Bladder cancer
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Hair follicle development organogenesis part 2 of 3
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Hair follicle development cytodifferentiation stage 3 of 3
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PCSK9 mediated LDL receptor degradation
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Pluripotent stem cell differentiation pathway
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Hematopoietic stem cell differentiation
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The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
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Endoderm differentiation
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Gene regulatory network modeling somitogenesis
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Dopaminergic neurogenesis
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Mesodermal commitment pathway
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Ectoderm differentiation
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IL3 signaling
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Apoptosis related network due to altered Notch3 in ovarian cancer
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IL1 and megakaryocytes in obesity
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TCA cycle nutrient use and invasiveness of ovarian cancer
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Extracellular vesicle mediated signaling in recipient cells
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Liver X receptor pathway
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Constitutive androstane receptor pathway
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Pregnane X receptor pathway
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Vitamin D receptor pathway
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PPAR alpha pathway
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Farnesoid X receptor pathway
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Nod like receptor NLR signaling
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Glucocorticoid receptor pathway
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Estrogen receptor pathway
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Nuclear receptors meta pathway
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NRF2 pathway
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Oxytocin signaling
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Myometrial relaxation and contraction pathways
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Differentiation of white and brown adipocyte
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miRNA targets in ECM and membrane receptors
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Interactome of polycomb repressive complex 2 PRC2
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DDX1 as a regulatory component of the Drosha microprocessor
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Hypoxia mediated EMT and stemness
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Nuclear receptors in lipid metabolism and toxicity
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Transcriptional activation by NRF2 in response to phytochemicals
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Kit receptor signaling
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Focal adhesion
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Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
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Hepatocyte growth factor receptor signaling
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Fas ligand pathway and stress induction of heat shock proteins
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Osteoblast signaling
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Triacylglyceride synthesis
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Copper homeostasis
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Overview of nanoparticle effects
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EV release from cardiac cells and their functional effects
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Melatonin metabolism and effects
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let 7 inhibition of ES cell reprogramming
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Dual hijack model of Vif in HIV infection
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MFAP5 mediated ovarian cancer cell motility and invasiveness
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eIF5A regulation in response to inhibition of the nuclear export system
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RAC1 PAK1 p38 MMP2 pathway
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GPCRs class B secretin like
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Senescence associated secretory phenotype SASP
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Ovarian infertility
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FTO obesity variant mechanism
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Evolocumab mechanism to reduce LDL cholesterol
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NOTCH1 regulation of endothelial cell calcification
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Initiation of transcription and translation elongation at the HIV 1 LTR
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G protein signaling
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Pre implantation embryo
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Zinc homeostasis
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Fatty acid biosynthesis
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Methionine de novo and salvage pathway
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MECP2 and associated Rett syndrome
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Cytosine methylation
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Sleep regulation
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MicroRNA for targeting cancer growth and vascularization in glioblastoma
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Circadian rhythm genes
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mir 124 predicted interactions with cell cycle and differentiation
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miR 517 relationship with ARCN1 and USP1
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Transcription factor regulation in adipogenesis
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Lipid particles composition
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Photodynamic therapy induced AP 1 survival signaling
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Photodynamic therapy induced NFE2L2 NRF2 survival signaling
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Photodynamic therapy induced unfolded protein response
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Photodynamic therapy induced HIF 1 survival signaling
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Photodynamic therapy induced NF kB survival signaling
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Lung fibrosis
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Gut liver indole metabolism
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Wnt signaling
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NAD metabolism sirtuins and aging
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Caffeine and theobromine metabolism
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Insulin signaling in adipocytes normal condition
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Insulin signaling in adipocytes diabetic condition
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IL6 signaling
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Imatinib and chronic myeloid leukemia
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NAD metabolism
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NAD biosynthetic pathways
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Hepatitis C and hepatocellular carcinoma
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Pathways affected in adenoid cystic carcinoma
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Hypothetical craniofacial development pathway
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Interleukin 1 induced activation of NF kB
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Hematopoietic stem cell gene regulation by GABP alpha beta complex
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Wnt beta catenin signaling in leukemia
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TGF beta signaling pathway
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Regulation of Wnt B catenin signaling by small molecule compounds
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Metabolism of dichloroethylene by CYP450
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Hypothesized pathways in pathogenesis of cardiovascular disease
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Interactions between LOXL4 and oxidative stress pathway
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lncRNA mediated mechanisms of therapeutic resistance
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Tgif disruption of Shh signaling
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BDNF TrkB signaling
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Amplification and expansion of oncogenic pathways as metastatic traits
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Cell type dependent selectivity of CCK2R signaling
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Mitochondrial long chain fatty acid beta oxidation
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Physico chemical features and toxicity associated pathways
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MAPK signaling
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Striated muscle contraction pathway
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Apoptosis modulation by HSP70
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PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer
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Canonical and non canonical Notch signaling
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MAPK and NFkB signaling inhibited by Yersinia YopJ
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Factors and pathways affecting insulin like growth factor IGF1 Akt signaling
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TLR4 signaling and tolerance
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ERK pathway in Huntington 39 s disease
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Toll like receptor signaling related to MyD88
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TGF beta signaling in thyroid cells for epithelial mesenchymal transition
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T cell antigen receptor TCR pathway during Staphylococcus aureus infection
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Novel intracellular components of RIG I like receptor pathway
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Cannabinoid receptor signaling
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Valproic acid pathway
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Regulation of apoptosis by parathyroid hormone related protein
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RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis
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Canonical and non canonical TGF B signaling
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ATR signaling
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BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation
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MYD88 distinct input output pathway
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ATM signaling in development and disease
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4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression
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VEGFA VEGFR2 signaling
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Nanomaterial induced inflammasome activation
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Benzene metabolism
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Development of pulmonary dendritic cells and macrophage subsets
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Development and heterogeneity of the ILC family
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Dengue 2 interactions with complement and coagulation cascades
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Mitochondrial gene expression
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Angiopoietin like protein 8 regulatory pathway
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Hfe effect on hepcidin production
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Amino acid metabolism
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ApoE and miR 146 in inflammation and atherosclerosis
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BMP signaling in eyelid development
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Chemokine signaling
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EDA signaling in hair follicle development
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Embryonic stem cell pluripotency pathways
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Focal adhesion PI3K Akt mTOR signaling
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Kennedy pathway from sphingolipids
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Leptin and adiponectin
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Leptin insulin signaling overlap
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Microglia pathogen phagocytosis pathway
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miR 222 in exercise induced cardiac growth
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Oxidative damage response
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PPAR signaling
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ROBO4 and VEGF signaling crosstalk
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Serotonin and anxiety related events
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TYROBP causal network in microglia
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Serotonin and anxiety
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IL4 signaling
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mRNA protein and metabolite inducation pathway by cyclosporin A
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GPR40 pathway
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DNA IR double strand breaks and cellular response via ATM
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Mevalonate pathway
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Lipid metabolism pathway
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miR 509 3p alteration of YAP1 ECM axis
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H19 Rb E2F1 and CDK beta catenin in colorectal cancer
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OSX and miRNAs in tooth development
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PDGFR beta pathway
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miRNA regulation of prostate cancer signaling
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miRNA regulation of p53 pathway in prostate cancer
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Wnt signaling and pluripotency
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Prion disease pathway
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Ethanol effects on histone modifications
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Prader Willi and Angelman syndrome
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p38 MAPK signaling
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NO cGMP PKG mediated neuroprotection
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DNA IR damage and cellular response via ATR
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Clear cell renal cell carcinoma pathways
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SCFA and skeletal muscle substrate metabolism
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Eukaryotic transcription initiation
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Oxidative stress response
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Exercise induced circadian regulation
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mRNA processing
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Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
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Fibrin complement receptor 3 signaling
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PI3K AKT mTOR vitamin D3 signaling
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Metabolism of sphingolipids in ER and Golgi apparatus
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Macrophage markers
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PTF1A related regulatory pathway
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Splicing factor NOVA regulated synaptic proteins
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White fat cell differentiation
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The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole.
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Wnt signaling in kidney disease
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Degradation pathway of sphingolipids including diseases
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Endometrial cancer
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A uterine cancer that is located_in tissues lining the uterus.
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Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine
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GABA metabolism aka GHB
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GABA receptor signaling
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PI3K Akt signaling
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Metabolism of tetrahydrocannabinol THC
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Somatroph axis GH and its relationship to dietary restriction and aging
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Mevalonate arm of cholesterol biosynthesis pathway with inhibitors
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Mevalonate arm of cholesterol biosynthesis pathway
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Caloric restriction and aging
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Hormonal control of pubertal growth spurt
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Immune response to tuberculosis
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Tumor suppressor activity of SMARCB1
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MET in type 1 papillary renal cell carcinoma
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Hereditary leiomyomatosis and renal cell carcinoma pathway
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Tryptophan catabolism leading to NAD production
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Transcriptional cascade regulating adipogenesis
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Chromosomal and microsatellite instability in colorectal cancer
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Ebola virus infection in host
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MAPK cascade
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An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
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Neurotransmitter disorders
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Phosphodiesterases in neuronal function
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Ras signaling
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Purine metabolism and related disorders
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Pyrimidine metabolism and related diseases
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Vitamin B6 dependent and responsive disorders
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Acrylamide biotransformation and exposure biomarkers
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Krebs cycle disorders
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Flavan 3 ol metabolic pathway
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Epithelial to mesenchymal transition in colorectal cancer
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Regulation of sister chromatid separation at the metaphase anaphase transition
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Type 2 papillary renal cell carcinoma
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Hedgehog signaling
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Non small cell lung cancer
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lncRNA in canonical Wnt signaling and colorectal cancer
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Disorders of folate metabolism and transport
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Breast cancer pathway
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Pancreatic adenocarcinoma pathway
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Ethanol metabolism production of ROS by CYP2E1
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Vitamin B12 disorders
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Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer
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MTHFR deficiency
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Metabolic reprogramming in colon cancer
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Methionine metabolism leading to sulfur amino acids and related disorders
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Thiamine metabolic pathways
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Acute viral myocarditis
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Lamin A processing pathway
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Oxidation by cytochrome P450
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Statin inhibition of cholesterol production
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Extracellular vesicles in the crosstalk of cardiac cells
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Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells
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Oligodendrocyte specification and differentiation leading to myelin components for CNS
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Rett syndrome
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A pervasive developmental disease that is a neurological and developmental disorder that mostly occurs in females and is caused_by a mutation on the MECP2 gene on the X chromosome. Infants with Rett syndrome seem to grow and develop normally at first, but then stop developing and even lose skills and abilities.
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Ferroptosis
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Malate aspartate shuttle
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miRNA degrading enzymes
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Mitochondrial fatty acid synthesis pathway
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Mitochondrial fission and fusion
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Effect of progerin on genes involved in progeria
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Thermogenesis
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Mitochondrial complex I assembly model OXPHOS system
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miRNA role in immune response in sepsis
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Neovascularization processes
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ncRNAs in Wnt signaling in hepatocellular carcinoma
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ncRNAs involved in STAT3 signaling in hepatocellular carcinoma
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Non genomic actions of 1 25 dihydroxyvitamin D3
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Vitamins A and D action mechanisms
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Ciliary landscape
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NRF2 ARE regulation
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EGF EGFR signaling
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|
Non homologous end joining
|
|
|
Bile acid synthesis and enterohepatic circulation
|
|
|
Nonalcoholic fatty liver disease
|
|
|
Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors
|
|
|
MicroRNA network associated with chronic lymphocytic leukemia
|
|
|
FABP4 in ovarian cancer
|
|
|
Platelet mediated interactions with vascular and circulating cells
|
|
|
LTF danger signal response pathway
|
|
|
Suppression of HMGB1 mediated inflammation by THBD
|
|
|
Altered glycosylation of MUC1 in tumor microenvironment
|
|
|
Resistin as a regulator of inflammation
|
|
|
Vitamin D in inflammatory diseases
|
|
|
Relationship between inflammation COX 2 and EGFR
|
|
|
Control of immune tolerance by vasoactive intestinal peptide
|
|
|
Cells and molecules involved in local acute inflammatory response
|
|
|
Selective expression of chemokine receptors during T cell polarization
|
|
|
IL10 anti inflammatory signaling
|
|
|
Signal transduction through IL1R
|
|
|
G1 to S cell cycle control
|
|
|
Cysteine and methionine catabolism
|
|
|
Tyrosine metabolism and related disorders
|
|
|
Molybdenum cofactor Moco biosynthesis
|
|
|
Gamma glutamyl cycle for the biosynthesis and degradation of glutathione including diseases
|
|
|
Cerebral organic acidurias including diseases
|
|
|
Glycosylation and related congenital defects
|
|
|
Metabolic pathway of LDL HDL and TG including diseases
|
|
|
Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism
|
|
|
Alternative pathway of fetal androgen synthesis
|
|
|
Inflammatory response pathway
|
|
|
Intraflagellar transport proteins binding to dynein
|
|
|
Transcription co factors SKI and SKIL protein partners
|
|
|
Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms
|
|
|
Envelope proteins and their potential roles in EDMD physiopathology
|
|
|
Genes related to primary cilium development based on CRISPR
|
|
|
Hippo YAP signaling
|
|
|
Regulatory circuits of STAT3 signaling
|
|
|
Synaptic signaling associated with autism spectrum disorder
|
|
|
Hippo signaling regulation
|
|
|
Hippo Merlin signaling dysregulation
|
|
|
Leukocyte intrinsic Hippo pathway functions
|
|
|
Oxysterols derived from cholesterol
|
|
|
Fragile X syndrome
|
A neurodegenerative disease that is characterized by moderate to severe mental retardation, macroorchidism, and distinct facial features, including long face, large ears, and prominent jaw, and has_material_basis_in a loss of FMR1 function.
|
|
GPCRs class A rhodopsin like
|
|
|
FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma
|
|
|
Interferon mediated signaling
|
|
|
Interactions between immune cells and microRNAs in tumor microenvironment
|
|
|
MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement
|
|
|
Canonical NF kB pathway
|
|
|
Neural crest cell migration during development
|
|
|
Neural crest cell migration in cancer
|
|
|
Translation inhibitors in chronically activated PDGFRA cells
|
|
|
Urea cycle and related diseases
|
|
|
Neurodegeneration with brain iron accumulation NBIA subtypes pathway
|
|
|
Cancer immunotherapy by CTLA4 blockade
|
|
|
Biomarkers for urea cycle disorders
|
|
|
Biomarkers for pyrimidine metabolism disorders
|
|
|
Cancer immunotherapy by PD 1 blockade
|
|
|
Metabolism of alpha linolenic acid
|
|
|
Major receptors targeted by epinephrine and norepinephrine
|
|
|
Urea cycle and associated pathways
|
|
|
Aerobic glycolysis augmented
|
|
|
Aerobic glycolysis
|
|
|
Measles virus infection
|
|
|
Tryptophan metabolism
|
|
|
Cytosolic DNA sensing pathway
|
|
|
Joubert syndrome
|
An autosomal recessive disease that is characterized by congenital malformation of the brainstem and agenesis or hypoplasia of the cerebellar vermis leading to an abnormal respiratory pattern, nystagmus, hypotonia, ataxia, and delay in achieving motor milestones resulting from dysfunction of ciliary proteins (ciliopathy).
|
|
22q11 2 copy number variation syndrome
|
|
|
Small cell lung cancer
|
|
|
Gastrin signaling
|
|
|
DNA replication
|
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
|
|
Amino acid metabolism pathway excerpt histidine catabolism extension
|
|
|
Hepatitis B infection
|
|
|
Male infertility
|
|
|
Head and neck squamous cell carcinoma
|
A squamous cell carcinoma that arises from any of the following anatomic sites: lip and oral cavity, nasal cavity, paranasal sinuses, pharynx, larynx, and salivary glands.|A carcinoma of any tissue within the head and neck region.
|
|
Melanoma
|
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)|A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain.
|
|
Leucine isoleucine and valine metabolism
|
|
|
Serine metabolism
|
|
|
Vitamin D sensitive calcium signaling in depression
|
|
|
Pathways of nucleic acid metabolism and innate immune sensing
|
|
|
Aspirin and miRNAs
|
|
|
Cholesterol metabolism with Bloch and Kandutsch Russell pathways
|
|
|
Eicosanoid metabolism via cyclooxygenases COX
|
|
|
Eicosanoid metabolism via cytochrome P450 monooxygenases pathway
|
|
|
Eicosanoid metabolism via lipooxygenases LOX
|
|
|
Glycerolipids and glycerophospholipids
|
|
|
Omega 3 omega 6 fatty acid synthesis
|
|
|
Omega 9 fatty acid synthesis
|
|
|
Sphingolipid metabolism overview
|
|
|
Sphingolipid metabolism integrated pathway
|
|
|
Endochondral ossification
|
Replacement ossification wherein bone tissue replaces cartilage.
|
|
Ketogenesis and ketolysis
|
|
|
Thyroid hormones production and peripheral downstream signaling effects
|
|
|
Netrin UNC5B signaling
|
|
|
HIPK2 in kidney fibrosis
|
|
|
Base excision repair
|
|
|
Nucleotide excision repair
|
disease cluster belonging to disease group other
|
|
IL18 signaling
|
|
|
Renin angiotensin aldosterone system RAAS
|
|
|
Nephrotic syndrome
|
Xref MGI.
|
|
PKC gamma calcium signaling in ataxia
|
|
|
FGFR3 signaling in chondrocyte proliferation and terminal differentiation
|
|
|
Cytoplasmic ribosomal proteins
|
|
|
Proteoglycan biosynthesis
|
|
|
Somitogenesis in the context of spondylocostal dysostosis
|
|
|
Type I collagen synthesis in the context of osteogenesis imperfecta
|
|
|
Osteoblast differentiation and related diseases
|
|
|
Autosomal recessive osteopetrosis pathways
|
|
|
Multiple epiphyseal dysplasia and pseudoachondroplasia genes
|
|
|
FGF23 signaling in hypophosphatemic rickets and related disorders
|
|
|
Purine metabolism
|
|
|
Downregulation of ACE2 by SARS CoV 2 spike protein
|
|
|
Ciliopathies
|
|
|
Cholesterol biosynthesis with skeletal dysplasias
|
|
|
EGFR tyrosine kinase inhibitor resistance
|
|
|
Endochondral ossification with skeletal dysplasias
|
|
|
Insulin signaling
|
|
|
Somatic sex determination
|
The determination of sex and sexual phenotypes in an organism's soma.
|
|
Glycosaminoglycan degradation
|
|
|
TGF beta receptor signaling in skeletal dysplasias
|
|
|
Conversion of angiotensinogen to angiotensin II
|
|
|
Genes controlling nephrogenesis
|
|
|
mBDNF and proBDNF regulation of GABA neurotransmission
|
|
|
GDNF RET signaling axis
|
|
|
Regucalcin in proximal tubule epithelial kidney cells
|
|
|
Mammalian disorder of sexual development
|
|
|
Influence of laminopathies on Wnt signaling
|
|
|
SARS CoV 2 and COVID 19 pathway
|
|
|
Linoleic acid metabolism affected by SARS CoV 2
|
|
|
Intracellular trafficking proteins involved in CMT neuropathy
|
|
|
Hijack of ubiquitination by SARS CoV 2
|
|
|
Endoplasmic reticulum stress response in coronavirus infection
|
|
|
Host pathogen interaction of human coronaviruses autophagy
|
|
|
Host pathogen interaction of human coronaviruses apoptosis
|
|
|
Type I interferon induction and signaling during SARS CoV 2 infection
|
|
|
Kisspeptin kisspeptin receptor system in the ovary
|
|
|
MAP3K1 role in promoting and blocking gonadal determination
|
|
|
Peroxiredoxin 2 induced ovarian failure
|
|
|
CAMKK2 pathway
|
|
|
Disruption of postsynaptic signaling by CNV
|
|
|
Activation of NLRP3 inflammasome by SARS CoV 2
|
|
|
Host pathogen interaction of human coronaviruses MAPK signaling
|
|
|
Overlap between signal transduction pathways contributing to LMNA laminopathies
|
|
|
Host pathogen interaction of human coronaviruses interferon induction
|
|
|
SARS CoV 2 and ACE2 receptor molecular mechanisms
|
|
|
Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex
|
|
|
COVID 19 adverse outcome pathway
|
|
|
IL2 signaling
|
|
|
Purinergic signaling
|
|
|
LDLRAD4 and what we know about it
|
|
|
1q21 1 copy number variation syndrome
|
|
|
3q29 copy number variation syndrome
|
|
|
SARS coronavirus and innate immunity
|
|
|
Proximal tubule transport
|
|
|
Cellular proteostasis
|
|
|
Neuroinflammation
|
|
|
Mitochondrial complex II assembly
|
|
|
Mitochondrial complex III assembly
|
|
|
Mitochondrial complex IV assembly
|
|
|
Autophagy
|
The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
|
|
Unfolded protein response
|
|
|
COVID 19 thrombosis and anticoagulation
|
|
|
MAPK pathway in congenital thyroid cancer
|
|
|
Direct reversal repair
|
|
|
7q11 23 copy number variation syndrome
|
|
|
Perturbations to host cell autophagy induced by SARS CoV 2 proteins
|
|
|
15q11 2 copy number variation syndrome
|
|
|
GPR143 in melanocytes and retinal pigment epithelium cells
|
|
|
15q13 3 copy number variation syndrome
|
|
|
DNA repair pathways full network
|
|
|
Nitric oxide metabolism in cystic fibrosis
|
|
|
16p11 2 proximal deletion syndrome
|
|
|
16p11 2 distal deletion syndrome
|
|
|
Steroid biosynthesis
|
|
|
STING pathway in Kawasaki like disease and COVID 19
|
|
|
Airway smooth muscle cell contraction
|
|
|
p53 transcriptional gene network
|
|
|
Fluoroacetic acid toxicity
|
|
|
RAS and bradykinin pathways in COVID 19
|
|
|
Urea cycle and metabolism of amino groups
|
|
|
Galanin receptor pathway
|
|
|
Phosphoinositides metabolism
|
|
|
Glycogen synthesis and degradation
|
|
|
GPCRs class C metabotropic glutamate pheromone
|
|
|
Proline and hydroxyproline pathways
|
|
|
nsp1 from SARS CoV 2 inhibits translation initiation in the host cell
|
|
|
Glycine metabolism including IMDs
|
|
|
Amino acid transport defects IEMs
|
|
|
Ethylmalonic encephalopathy
|
|
|
Biotin metabolism including IMDs
|
|
|
Genes associated with the development of rheumatoid arthritis
|
|
|
Angiotensin II receptor type 1 pathway
|
|
|
Riboflavin and CoQ disorders
|
|
|
Mitochondrial immune response to SARS CoV 2
|
|
|
SARS CoV 2 innate immunity evasion and cell specific immune response
|
|
|
Pentose phosphate pathway in senescent cells
|
|
|
Kynurenine pathway and links to cell senescence
|
|
|
NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence
|
|
|
Glycolysis in senescence
|
|
|
TCA cycle in senescence
|
|
|
Nephrogenesis
|
|
|
Development of ureteric derived collecting system
|
|
|
Burn wound healing
|
|
|
Fatty acid transporters
|
|
|
FOXP3 in COVID 19
|
|
|
7 oxo C and 7 beta HC pathways
|
|
|
SARS CoV 2 altering angiogenesis via NRP1
|
|
|
FOXA2 pathway
|
|
|
Modulators of TCR signaling and T cell activation
|
|
|
Kallmann syndrome
|
OMIM mapping confirmed by DO. [SN].
|
|
Soluble ACE2 mediated cell entry of SARS CoV 2
|
|
|
T cell modulation in pancreatic cancer
|
|
|
Neuroinflammation and glutamatergic signaling
|
|
|
Vasopressin regulated water reabsorption
|
|
|
Pleural mesothelioma
|
A Malignant mesothelioma originating from cells of the pleura (the thin layer of mesothelium lining the lungs). Pleural mesothelioma is the most common form of mesothelioma.
|
|
Prostaglandin signaling
|
|
|
Kinin Kallikrein pathway
|
|
|
Complement system in neuronal development and plasticity
|
|
|
Interactions of natural killer cells in pancreatic cancer
|
|
|
Opioid receptor pathways
|
|
|
Orexin receptor pathway
|
|
|
Overview of proinflammatory and profibrotic mediators
|
|
|
CCL18 signaling
|
|
|
T cell activation SARS CoV 2
|
|
|
Regulation of actin cytoskeleton
|
|
|
Congenital generalized lipodystrophy
|
OMIM mapping confirmed by DO. [SN].
|
|
Familial partial lipodystrophy
|
A lipodystrophy characterized by abnormal subcutaneous adipose tissue distribution beginning in late childhood or early adult life.
|
|
Progeria associated lipodystrophy
|
|
|
Acquired partial lipodystrophy Barraquer Simons syndrome
|
|
|
Familial hyperlipidemia type 1
|
|
|
Familial hyperlipidemia type 2
|
|
|
Familial hyperlipidemia type 3
|
|
|
Familial hyperlipidemia type 4
|
|
|
Familial hyperlipidemia type 5
|
|
|
Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway
|
|
|
Nucleotide excision repair in xeroderma pigmentosum
|
|
|
Network map of SARS CoV 2 signaling
|
|
|
SARS CoV 2 B 1 1 7 variant antagonises innate immune activation
|
|
|
Cohesin complex Cornelia de Lange syndrome
|
|
|
SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome
|
|
|
NIPBL role in DNA damage Cornelia de Lange syndrome
|
|
|
Inclusion body myositis
|
A myositis that is characterized by slowly progressive weakness and wasting of both distal and proximal muscles, most apparent in the muscles of the arms and legs that can occur in a sporadic or hereditary forms.
|
|
Sphingolipid metabolism in senescence
|
|
|
Prostaglandin and leukotriene metabolism in senescence
|
|
|
Mitochondrial fatty acid oxidation disorders
|
|
|
Alzheimer 39 s disease
|
|
|
Th17 cell differentiation pathway
|
|
|
Non classical role of vitamin D
|
|
|
ALA oxylipin metabolism
|
|
|
Linoleic acid oxylipin metabolism
|
|
|
Calcium mediated T cell apoptosis involved in inclusion body myositis
|
|
|
GDNF signaling
|
|
|
NRP1 triggered signaling in pancreatic cancer
|
|
|
COVID 19 structural coverage map
|
|
|
Lung pathology of COVID 19
|
|
|
Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway
|
|
|
Lipid metabolism in senescent cells
|
|
|
Spina bifida
|
|
|
Iron sulfur cluster biogenesis
|
|
|
N glycan biosynthesis
|
|
|
Docosahexaenoic acid oxylipin metabolism
|
|
|
Arachidonic acid AA ARA oxylipin metabolism
|
|
|
SARS CoV 2 replication organelle formation
|
|
|
Urotensin II mediated signaling
|
|
|
Hypertrophy model
|
|
|
Glyoxylate metabolism
|
|
|
Hemesynthesis defects and porphyrias
|
|
|
Leukotriene metabolic pathway
|
|
|
Iron metabolism disorders
|
|
|
Disorders of galactose metabolism
|
|
|
Ulcerative colitis signaling
|
|
|
Disorders in ketone body synthesis
|
|
|
Disorders of bile acid synthesis and biliary transport
|
|
|
Disorders of fructose metabolism
|
|
|
Biosynthesis and turnover of 1 deoxy sphingoid bases
|
|
|
DYRK1A involvement regarding cell proliferation in brain development
|
|
|
Roles of ceramides in development of insulin resistance
|
|
|
Pro survival signaling of neuroprotectin D1
|
|
|
SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction
|
|
|
Vitamin K metabolism and activation of dependent proteins
|
|
|
mRNA vaccine activation of dendritic cell and induction of IFN 1
|
|
|
Copper metabolism
|
|
|
Creatine pathway
|
|
|
Resolvin E1 and resolvin D1 signaling decrease inflammation
|
|
|
Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids
|
|
|
Cholesterol synthesis disorders
|
|
|
Synthesis of ceramides and 1 deoxyceramides
|
|
|
Disorders in ketolysis
|
|
|
Inflammatory bowel disease signaling
|
|
|
PtdIns 4 5 P2 in cytokinesis pathway
|
|
|
Dravet syndrome
|
An epilepsy that is characterized by frequent febrile seizures with onset before 1 year.
|
|
Alstrom syndrome
|
An autosomal recessive disease that is characterized by multiorgan dysfunction. The key features are childhood obesity, blindness due to congenital retinal dystrophy, and sensorineural hearing loss with autosomal recessive inheritance and has_material_basis_in mutations in the ALMS1 gene.
|
|
Clock controlled autophagy in bone metabolism
|
|
|
Amino acid conjugation of benzoic acid
|
|
|
Glucose metabolism in triple negative breast cancer cells
|
|
|
Amino acid metabolism in triple negative breast cancer cells
|
|
|
Relevant molecular pathways and targeted agents in triple negative breast cancer
|
|
|
Warburg effect modulated by deubiquitinating enzymes and their substrates
|
|
|
Extrafollicular and follicular B cell activation by SARS CoV 2
|
|
|
Diet dependent trimethylamine trimethylamine N oxide metabolism
|
|
|
Metabolic reprogramming in pancreatic cancer
|
|
|
2q11 2 copy number variation syndrome
|
|
|
2q13 copy number variation syndrome
|
|
|
2q21 1 copy number variation syndrome
|
|
|
2q37 copy number variation syndrome
|
|
|
Nephrotoxcicity adverse outcome pathway
|
|
|
Hippocampal synaptogenesis and neurogenesis
|
|
|
Arsenic metabolism and reactive oxygen species generation
|
|
|
Bardet Biedl syndrome
|
|
|
Estradiol regulation in porto sinusoidal vascular disease
|
|
|
Markers of kidney cell lineage
|
|
|
Cholestasis
|
|
|
Lac Phe pathway
|
|
|
G13 signaling
|
|
|
Mitochondrial beta oxidation
|
|
|
COVID 19 and endothelial cell senescence
|
|
|
ROS in COVID 19 endothelial dysfunction
|
|
|
Neurogenesis regulation in the olfactory epithelium
|
|
|
Genetic causes of porto sinusoidal vascular disease
|
|
|
LDL influence on CD14 and TLR4
|
|
|
Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists
|
|
|
Ether lipid biosynthesis
|
|
|
Estrogen metabolism
|
|
|
Steroid hormone precursor biosynthesis
|
|
|
Mineralocorticoid biosynthesis
|
|
|
Acetylcholine synthesis
|
|
|
Glucocorticoid biosynthesis
|
|
|
Chronic hyperglycemia impairment of neuron function
|
|
|
Cell interactions of the pancreatic cancer microenvironment
|
|
|
Immune infiltration in pancreatic cancer
|
|
|
17q12 copy number variation syndrome
|
|
|
Axon guidance
|
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
|
Glycosphingolipid metabolism
|
|
|
Acute myeloid leukemia
|
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
|
|
Sildenafil treatment
|
|
|
Ganglio series sphingolipid metabolism
|
|
|
ID signaling
|
|
|
Cytokines and inflammatory response
|
|
|
TROP2 regulatory signaling
|
|
|
Neolacto series sphingolipid metabolism
|
|
|
Lacto series sphingolipid metabolism
|
|
|
Cholesterol metabolism
|
|
|
DNA mismatch repair
|
|
|
Isoglobo series sphingolipids
|
|
|
Metabolic pathways of fibroblasts
|
|
|
Carnosine metabolism of glial cells
|
|
|
Lactate shuttle in glial cells
|
|
|
Sebaleic acid formation and metabolism
|
|
|
Primary ovarian insufficiency
|
|
|
Female steroid hormones in cardiomyocyte energy metabolism
|
|
|
Male steroid hormones in cardiomyocyte energy metabolism
|
|
|
Fatty acids and lipoproteins transport in hepatocytes
|
|
|
Octadecanoid formation from linoleic acid
|
|
|
Cholesterol biosynthesis pathway in hepatocytes
|
|
|
Autophagy in pancreatic ductal adenocarcinoma
|
|
|
Enterocyte cholesterol metabolism
|
|
|
Induction of autophagy and toll like receptor signaling by graphene oxide
|
|
|
Glycolysis and gluconeogenesis
|
|
|
Pathophysiological roles of DUX4 in FSHD1
|
|
|
Abnormal calcium handling and its effects on muscle contraction in DMD
|
|
|
Cardiomyocyte signaling converging on titin
|
|
|
1p36 copy number variation syndrome
|
|
|
8p23 1 copy number variation syndrome
|
|
|
IL26 signaling
|
|
|
11p11 2 copy number variation syndrome
|
|
|
Kleefstra syndrome
|
Kleefstra syndrome (KS) is a genetic disorder characterized by intellectual disability, childhood hypotonia, severe expressive speech delay and a distinctive facial appearance with a spectrum of additional clinical features.
|
|
10q11 21q11 23 copy number variation syndrome
|
|
|
Macrophage stimulating protein MSP signaling
|
|
|
Metabolic epileptic disorders
|
|
|
Affected pathways in Duchenne muscular dystrophy
|
|
|
JAK STAT signaling in the regulation of beta cells
|
|
|
Calcium regulation in cardiac cells
|
|
|
KCNQ2 related epilepsies
|
|
|
TAR syndrome
|
|
|
4p16 3 copy number variation
|
|
|
NF1 copy number variation syndrome
|
|
|
Rubinstein Taybi syndrome 1
|
|
|
Sulfatase and aromatase pathway
|
|
|
Involvement of secretase in neurodegenerative diseases
|
|
|
Osteoarthritic chondrocyte hypertrophy
|
|
|
17p13 3 YWHAE copy number variation
|
|
|
5q35 copy number variation
|
|
|
Smith Magenis and Potocki Lupski syndrome copy number variation
|
|
|
TGFB Smad signaling
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Growth factors and hormones in beta cell proliferation
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Pancreatic cancer subtypes
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UDP derived sugars synthesis in fibroblasts
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Glycosaminoglycan synthesis in fibroblasts
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Enterohepatic circulation of bile acids
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Vitamin A1 and A5 X pathways
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NRXN1 deletion syndrome
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NPHP1 deletion syndrome
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6q16 copy number variation
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7q11 23 distal copy number variation
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10q22q23 copy number variation
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13q12 or CRYL1 copy number variation
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13q12 12 copy number variation
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15q11q13 copy number variation
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15q25 copy number variation
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PAFAH1B1 copy number variation
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Phosphatidyl inositol phosphate pathway
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8q11 23 RB1CC1 copy number variation
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IDO metabolic pathway
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Cell lineage map for neuronal differentiation
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ADHD and autism ASD pathways
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IL19 signaling
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Omega 6 fatty acids in senescence
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HDAC6 interactions in the central nervous system
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FGFR4 p G388R signaling
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FLT3 p Gln640SerfsTer8 signaling
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PGK1 PKM2 KHKC KHKA acting as protein kinases
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Cancer pathways
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GNAQ pathways in port wine stain
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EPAC1 and PKA reduction of retinal inflammation
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Artemisinin inhibition of uveal melanoma
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Wnt Beta catenin signaling inhibitors in current and past clinical trials
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Effects of MFN2 mutation
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Acetaminophen in analgesia and antipyresis
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Hunger and satiety
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disease cluster belonging to disease group metabolic
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GLP 1 secretion from intestine to portal vein
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GLP 1 in pancreatic islet cells
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Complement activation
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Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
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GLP 1 from intestine and pancreas and role in glucose homeostasis
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Effect of omega 3 PUFA on Huntington 39 s disease pathways
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Cytokine cytokine receptor interaction
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Catabolism of skeletal muscle in cachexia
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Post COVID neuroinflammation
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Biogenic amine synthesis
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ACE inhibitor pathway
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Complement and coagulation cascades
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TGF beta receptor signaling
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Heme biosynthesis
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Monoamine GPCRs
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EPO receptor signaling
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Interferon type I signaling
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Type II interferon signaling
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Oxidative phosphorylation
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The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
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Glucose homeostasis
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Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
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ErbB signaling
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Arachidonate epoxygenase epoxide hydrolase
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Catalytic cycle of mammalian flavin containing monooxygenases FMOs
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T cell receptor signaling
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Polyol pathway
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Tamoxifen metabolism
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Sulfation biotransformation reaction
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Arylamine metabolism
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Benzo a pyrene metabolism
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Glucuronidation
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Aflatoxin B1 metabolism
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Metapathway biotransformation Phase I and II
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Methylation pathways
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Sudden infant death syndrome SIDS susceptibility pathways
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DNA damage response
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DNA damage response only ATM dependent
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Estrogen signaling
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Vitamin A and carotenoid metabolism
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Serotonin HTR1 group and FOS pathway
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Monoamine transport
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The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
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Serotonin receptor 2 and ELK SRF GATA4 signaling
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Serotonin receptor 4 6 7 and NR3C signaling
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Toll like receptor signaling
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TCA cycle aka Krebs or citric acid cycle
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Nucleotide GPCRs
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Prostaglandin synthesis and regulation
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