WikiPathways Pathways 2024 Dataset

Description Sets of proteins participating in pathways from WikiPathways updated for 2024
Measurement association by literature curation
Association protein-pathway associations from curated pathways
Category structural or functional annotations
Resource WikiPathways
Citation(s)
Last Updated 2024 Sep 25
Stats
  1. 8274 genes
  2. 880 pathways
  3. 35588 gene-pathway associations

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pathway Gene Sets

880 sets of proteins participating in pathways from the WikiPathways Pathways 2024 dataset.

Gene Set Description
10q11 21q11 23 copy number variation syndrome
10q22q23 copy number variation
11p11 2 copy number variation syndrome
13q12 12 copy number variation
13q12 or CRYL1 copy number variation
15q11 2 copy number variation syndrome
15q11q13 copy number variation
15q13 3 copy number variation syndrome
15q25 copy number variation
16p11 2 distal deletion syndrome
16p11 2 proximal deletion syndrome
17p13 3 YWHAE copy number variation
17q12 copy number variation syndrome
1p36 copy number variation syndrome
1q21 1 copy number variation syndrome
22q11 2 copy number variation syndrome
2q11 2 copy number variation syndrome
2q13 copy number variation syndrome
2q21 1 copy number variation syndrome
2q37 copy number variation syndrome
3q29 copy number variation syndrome
4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression
4p16 3 copy number variation
5q35 copy number variation
6q16 copy number variation
7 oxo C and 7 beta HC pathways
7q11 23 copy number variation syndrome
7q11 23 distal copy number variation
8p23 1 copy number variation syndrome
8q11 23 RB1CC1 copy number variation
Abnormal calcium handling and its effects on muscle contraction in DMD
ACE inhibitor pathway
Acetaminophen in analgesia and antipyresis
Acetylcholine synthesis
Acquired partial lipodystrophy Barraquer Simons syndrome
Acrylamide biotransformation and exposure biomarkers
Activation of NLRP3 inflammasome by SARS CoV 2
Acute myeloid leukemia Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Acute viral myocarditis
ADHD and autism ASD pathways
Adipogenesis
Aerobic glycolysis
Aerobic glycolysis augmented
Affected pathways in Duchenne muscular dystrophy
Aflatoxin B1 metabolism
AGE RAGE pathway
Airway smooth muscle cell contraction
ALA oxylipin metabolism
Alanine and aspartate metabolism
Allograft rejection
Alpha 6 beta 4 signaling
Alstrom syndrome An autosomal recessive disease that is characterized by multiorgan dysfunction. The key features are childhood obesity, blindness due to congenital retinal dystrophy, and sensorineural hearing loss with autosomal recessive inheritance and has_material_basis_in mutations in the ALMS1 gene.
Altered glycosylation of MUC1 in tumor microenvironment
Alternative pathway of fetal androgen synthesis
Alzheimer 39 s disease
Alzheimer 39 s disease and miRNA effects
Amino acid conjugation of benzoic acid
Amino acid metabolism
Amino acid metabolism in triple negative breast cancer cells
Amino acid metabolism pathway excerpt histidine catabolism extension
Amino acid transport defects IEMs
AMP activated protein kinase signaling
Amplification and expansion of oncogenic pathways as metastatic traits
Amyotrophic lateral sclerosis ALS
Androgen receptor network in prostate cancer
Androgen receptor signaling
Angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
Angiopoietin like protein 8 regulatory pathway
Angiotensin II receptor type 1 pathway
Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway
ApoE and miR 146 in inflammation and atherosclerosis
Apoptosis
Apoptosis modulation and signaling
Apoptosis modulation by HSP70
Apoptosis related network due to altered Notch3 in ovarian cancer
Arachidonate epoxygenase epoxide hydrolase
Arachidonic acid AA ARA oxylipin metabolism
Aripiprazole metabolic pathway
Arrhythmogenic right ventricular cardiomyopathy An intrinsic cardiomyopathy that is characterized by hypokinetic areas involving the free wall of the right ventricle, with fibrofatty replacement of the right ventricular myocardium, with associated arrhythmias originating in the right ventricle.
Arsenic metabolism and reactive oxygen species generation
Artemisinin inhibition of uveal melanoma
Aryl hydrocarbon receptor pathway
Arylamine metabolism
Aspirin and miRNAs
ATM signaling
ATM signaling in development and disease
ATR signaling
Autophagy The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
Autophagy in pancreatic ductal adenocarcinoma
Autosomal recessive osteopetrosis pathways
Axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
B cell receptor signaling
Bardet Biedl syndrome
Base excision repair
BDNF TrkB signaling
Benzene metabolism
Benzo a pyrene metabolism
Bile acid synthesis and enterohepatic circulation
Biogenic amine synthesis
Biomarkers for pyrimidine metabolism disorders
Biomarkers for urea cycle disorders
Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine
Biosynthesis and turnover of 1 deoxy sphingoid bases
Biotin metabolism including IMDs
Bladder cancer
Blood clotting cascade
BMP signaling in eyelid development
BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation
Bone morphogenic protein signaling and regulation
Brain derived neurotrophic factor BDNF signaling
Breast cancer pathway
Burn wound healing
Butyrate induced histone acetylation
Caffeine and theobromine metabolism
Calcium mediated T cell apoptosis involved in inclusion body myositis
Calcium regulation in cardiac cells
Caloric restriction and aging
CAMKK2 pathway
Cancer immunotherapy by CTLA4 blockade
Cancer immunotherapy by PD 1 blockade
Cancer pathways
Cannabinoid receptor signaling
Canonical and non canonical Notch signaling
Canonical and non canonical TGF B signaling
Canonical NF kB pathway
Cardiac hypertrophic response
Cardiac progenitor differentiation
Cardiomyocyte signaling converging on titin
Carnosine metabolism of glial cells
Catabolism of skeletal muscle in cachexia
Catalytic cycle of mammalian flavin containing monooxygenases FMOs
CCL18 signaling
Cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
Cell differentiation expanded index
Cell differentiation index
Cell interactions of the pancreatic cancer microenvironment
Cell lineage map for neuronal differentiation
Cell type dependent selectivity of CCK2R signaling
Cells and molecules involved in local acute inflammatory response
Cellular proteostasis
Cerebral organic acidurias including diseases
Chemokine signaling
Cholestasis
Cholesterol biosynthesis pathway
Cholesterol biosynthesis pathway in hepatocytes
Cholesterol biosynthesis with skeletal dysplasias
Cholesterol metabolism
Cholesterol metabolism with Bloch and Kandutsch Russell pathways
Cholesterol synthesis disorders
Chromosomal and microsatellite instability in colorectal cancer
Chronic hyperglycemia impairment of neuron function
Ciliary landscape
Ciliopathies
Circadian rhythm genes
Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism
Clear cell renal cell carcinoma pathways
Clock controlled autophagy in bone metabolism
Cocaine metabolism
Codeine and morphine metabolism
Cohesin complex Cornelia de Lange syndrome
Colchicine metabolic pathway
Common pathways underlying drug addiction
Complement activation Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
Complement and coagulation cascades
Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway
Complement system
Complement system in neuronal development and plasticity
Congenital generalized lipodystrophy OMIM mapping confirmed by DO. [SN].
Constitutive androstane receptor pathway
Control of immune tolerance by vasoactive intestinal peptide
Conversion of angiotensinogen to angiotensin II
Copper homeostasis
Copper metabolism
Cori cycle
Corticotropin releasing hormone signaling
COVID 19 adverse outcome pathway
COVID 19 and endothelial cell senescence
COVID 19 structural coverage map
COVID 19 thrombosis and anticoagulation
Creatine pathway
Cysteine and methionine catabolism
Cytokine cytokine receptor interaction
Cytokines and inflammatory response
Cytoplasmic ribosomal proteins
Cytosine methylation
Cytosolic DNA sensing pathway
DDX1 as a regulatory component of the Drosha microprocessor
Degradation pathway of sphingolipids including diseases
Dengue 2 interactions with complement and coagulation cascades
Deregulation of Rab and Rab effector genes in bladder cancer
Development and heterogeneity of the ILC family
Development of pulmonary dendritic cells and macrophage subsets
Development of ureteric derived collecting system
Diclofenac metabolic pathway
Diet dependent trimethylamine trimethylamine N oxide metabolism
Differentiation of white and brown adipocyte
Direct reversal repair
Disorders in ketolysis
Disorders in ketone body synthesis
Disorders of bile acid synthesis and biliary transport
Disorders of folate metabolism and transport
Disorders of fructose metabolism
Disorders of galactose metabolism
Disruption of postsynaptic signaling by CNV
DNA damage response
DNA damage response only ATM dependent
DNA IR damage and cellular response via ATR
DNA IR double strand breaks and cellular response via ATM
DNA mismatch repair
DNA repair pathways full network
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
Docosahexaenoic acid oxylipin metabolism
Dopamine metabolism
Dopaminergic neurogenesis
Downregulation of ACE2 by SARS CoV 2 spike protein
Dravet syndrome An epilepsy that is characterized by frequent febrile seizures with onset before 1 year.
Drug induction of bile acid pathway
Dual hijack model of Vif in HIV infection
DYRK1A involvement regarding cell proliferation in brain development
Ebola virus infection in host
Ebstein Barr virus LMP1 signaling
Ectoderm differentiation
EDA signaling in hair follicle development
Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists
Effect of omega 3 PUFA on Huntington 39 s disease pathways
Effect of progerin on genes involved in progeria
Effects of MFN2 mutation
Effects of nitric oxide
EGF EGFR signaling
EGFR tyrosine kinase inhibitor resistance
Eicosanoid metabolism via cyclooxygenases COX
Eicosanoid metabolism via cytochrome P450 monooxygenases pathway
Eicosanoid metabolism via lipooxygenases LOX
Eicosanoid synthesis
eIF5A regulation in response to inhibition of the nuclear export system
Electron transport chain OXPHOS system in mitochondria
Embryonic stem cell pluripotency pathways
Endochondral ossification Replacement ossification wherein bone tissue replaces cartilage.
Endochondral ossification with skeletal dysplasias
Endoderm differentiation
Endometrial cancer A uterine cancer that is located_in tissues lining the uterus.
Endoplasmic reticulum stress response in coronavirus infection
Endothelin pathways
Energy metabolism
Enterocyte cholesterol metabolism
Enterohepatic circulation of bile acids
Envelope proteins and their potential roles in EDMD physiopathology
EPAC1 and PKA reduction of retinal inflammation
Epithelial to mesenchymal transition in colorectal cancer
EPO receptor signaling
ErbB signaling
ERK pathway in Huntington 39 s disease
Estradiol regulation in porto sinusoidal vascular disease
Estrogen metabolism
Estrogen receptor pathway
Estrogen signaling
Ethanol effects on histone modifications
Ethanol metabolism production of ROS by CYP2E1
Ether lipid biosynthesis
Ethylmalonic encephalopathy
Eukaryotic transcription initiation
EV release from cardiac cells and their functional effects
Evolocumab mechanism to reduce LDL cholesterol
Exercise induced circadian regulation
exRNA mechanism of action and biogenesis
Extracellular vesicle mediated signaling in recipient cells
Extracellular vesicles in the crosstalk of cardiac cells
Extrafollicular and follicular B cell activation by SARS CoV 2
FABP4 in ovarian cancer
Factors and pathways affecting insulin like growth factor IGF1 Akt signaling
Familial hyperlipidemia type 1
Familial hyperlipidemia type 2
Familial hyperlipidemia type 3
Familial hyperlipidemia type 4
Familial hyperlipidemia type 5
Familial partial lipodystrophy A lipodystrophy characterized by abnormal subcutaneous adipose tissue distribution beginning in late childhood or early adult life.
Farnesoid X receptor pathway
Fas ligand pathway and stress induction of heat shock proteins
Fatty acid beta oxidation
Fatty acid biosynthesis
Fatty acid omega oxidation
Fatty acid transporters
Fatty acids and lipoproteins transport in hepatocytes
FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma
Felbamate metabolism
Female steroid hormones in cardiomyocyte energy metabolism
Ferroptosis
FGF23 signaling in hypophosphatemic rickets and related disorders
FGFR3 signaling in chondrocyte proliferation and terminal differentiation
FGFR4 p G388R signaling
Fibrin complement receptor 3 signaling
Flavan 3 ol metabolic pathway
FLT3 p Gln640SerfsTer8 signaling
Fluoroacetic acid toxicity
Fluoropyrimidine activity
Focal adhesion Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
Focal adhesion PI3K Akt mTOR signaling
Folate alcohol and cancer pathway hypotheses
Folate metabolism
Follicle stimulating hormone FSH signaling
FOXA2 pathway
FOXP3 in COVID 19
Fragile X syndrome A neurodegenerative disease that is characterized by moderate to severe mental retardation, macroorchidism, and distinct facial features, including long face, large ears, and prominent jaw, and has_material_basis_in a loss of FMR1 function.
FTO obesity variant mechanism
G protein signaling
G1 to S cell cycle control
G13 signaling
GABA metabolism aka GHB
GABA receptor signaling
Galanin receptor pathway
Gamma glutamyl cycle for the biosynthesis and degradation of glutathione including diseases
Ganglio series sphingolipid metabolism
Ganglio sphingolipid metabolism
Gastric acid production
Gastric cancer network 1
Gastric cancer network 2
Gastrin signaling
GDNF RET signaling axis
GDNF signaling
Gene regulatory network modeling somitogenesis
Genes associated with the development of rheumatoid arthritis
Genes controlling nephrogenesis
Genes related to primary cilium development based on CRISPR
Genes targeted by miRNAs in adipocytes
Genetic causes of porto sinusoidal vascular disease
Glial cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.
Glioblastoma signaling
GLP 1 from intestine and pancreas and role in glucose homeostasis
GLP 1 in pancreatic islet cells
GLP 1 secretion from intestine to portal vein
Glucocorticoid biosynthesis
Glucocorticoid receptor pathway
Glucose homeostasis Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
Glucose metabolism in triple negative breast cancer cells
Glucuronidation
Glutathione metabolism
Glycerolipids and glycerophospholipids
Glycerophospholipid biosynthetic pathway
Glycine metabolism
Glycine metabolism including IMDs
Glycogen synthesis and degradation
Glycolysis and gluconeogenesis
Glycolysis in senescence
Glycosaminoglycan degradation
Glycosaminoglycan synthesis in fibroblasts
Glycosphingolipid metabolism
Glycosylation and related congenital defects
Glyoxylate metabolism
GNAQ pathways in port wine stain
GPCRs class A rhodopsin like
GPCRs class B secretin like
GPCRs class C metabotropic glutamate pheromone
GPCRs other
GPR143 in melanocytes and retinal pigment epithelium cells
GPR40 pathway
Growth factors and hormones in beta cell proliferation
Gut liver indole metabolism
H19 Rb E2F1 and CDK beta catenin in colorectal cancer
Hair follicle development cytodifferentiation stage 3 of 3
Hair follicle development organogenesis part 2 of 3
HDAC6 interactions in the central nervous system
Head and neck squamous cell carcinoma A squamous cell carcinoma that arises from any of the following anatomic sites: lip and oral cavity, nasal cavity, paranasal sinuses, pharynx, larynx, and salivary glands.|A carcinoma of any tissue within the head and neck region.
Heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
Hedgehog signaling
Hematopoietic stem cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
Hematopoietic stem cell gene regulation by GABP alpha beta complex
Heme biosynthesis
Hemesynthesis defects and porphyrias
Hepatitis B infection
Hepatitis C and hepatocellular carcinoma
Hepatocyte growth factor receptor signaling
Hereditary leiomyomatosis and renal cell carcinoma pathway
Heroin metabolism
Hfe effect on hepcidin production
HIF1A and PPARG in cardiac hypertropthy
Hijack of ubiquitination by SARS CoV 2
HIPK2 in kidney fibrosis
Hippo Merlin signaling dysregulation
Hippo signaling regulation
Hippo YAP signaling
Hippocampal synaptogenesis and neurogenesis
Histone modifications
Homologous recombination
Hormonal control of pubertal growth spurt
Host pathogen interaction of human coronaviruses apoptosis
Host pathogen interaction of human coronaviruses autophagy
Host pathogen interaction of human coronaviruses interferon induction
Host pathogen interaction of human coronaviruses MAPK signaling
Hunger and satiety disease cluster belonging to disease group metabolic
Hypertrophy model
Hypothesized pathways in pathogenesis of cardiovascular disease
Hypothetical craniofacial development pathway
Hypoxia mediated EMT and stemness
ID signaling
IDO metabolic pathway
IL1 and megakaryocytes in obesity
IL1 signaling
IL10 anti inflammatory signaling
IL11 signaling
IL17 signaling
IL18 signaling
IL19 signaling
IL2 signaling
IL26 signaling
IL3 signaling
IL4 signaling
IL5 signaling
IL6 signaling
IL7 signaling
IL9 signaling
Imatinib and chronic myeloid leukemia
Immune infiltration in pancreatic cancer
Immune response to tuberculosis
Inclusion body myositis A myositis that is characterized by slowly progressive weakness and wasting of both distal and proximal muscles, most apparent in the muscles of the arms and legs that can occur in a sporadic or hereditary forms.
Induction of autophagy and toll like receptor signaling by graphene oxide
Inflammatory bowel disease signaling
Inflammatory response pathway
Influence of laminopathies on Wnt signaling
Influenza A virus infection
Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells
Initiation of transcription and translation elongation at the HIV 1 LTR
Insulin signaling
Insulin signaling in adipocytes diabetic condition
Insulin signaling in adipocytes normal condition
Integrated cancer pathway
Integrin mediated cell adhesion
Interactions between immune cells and microRNAs in tumor microenvironment
Interactions between LOXL4 and oxidative stress pathway
Interactions of natural killer cells in pancreatic cancer
Interactome of polycomb repressive complex 2 PRC2
Interferon mediated signaling
Interferon type I signaling
Interleukin 1 IL 1 structural pathway
Interleukin 1 induced activation of NF kB
Intracellular trafficking proteins involved in CMT neuropathy
Intraflagellar transport proteins binding to dynein
Involvement of secretase in neurodegenerative diseases
Irinotecan pathway
Iron metabolism disorders
Iron metabolism in placenta
Iron sulfur cluster biogenesis
Isoglobo series sphingolipids
JAK STAT signaling in the regulation of beta cells
Joubert syndrome An autosomal recessive disease that is characterized by congenital malformation of the brainstem and agenesis or hypoplasia of the cerebellar vermis leading to an abnormal respiratory pattern, nystagmus, hypotonia, ataxia, and delay in achieving motor milestones resulting from dysfunction of ciliary proteins (ciliopathy).
Kallmann syndrome OMIM mapping confirmed by DO. [SN].
KCNQ2 related epilepsies
Kennedy pathway from sphingolipids
Ketogenesis and ketolysis
Kinin Kallikrein pathway
Kisspeptin kisspeptin receptor system in the ovary
Kit receptor signaling
Kleefstra syndrome Kleefstra syndrome (KS) is a genetic disorder characterized by intellectual disability, childhood hypotonia, severe expressive speech delay and a distinctive facial appearance with a spectrum of additional clinical features.
Krebs cycle disorders
Kynurenine pathway and links to cell senescence
Lac Phe pathway
Lactate shuttle in glial cells
Lacto series sphingolipid metabolism
Lamin A processing pathway
LDL influence on CD14 and TLR4
LDLRAD4 and what we know about it
Leptin and adiponectin
Leptin insulin signaling overlap
Leptin signaling
let 7 inhibition of ES cell reprogramming
Leucine isoleucine and valine metabolism
Leukocyte intrinsic Hippo pathway functions
Leukotriene metabolic pathway
Lidocaine metabolism
Linoleic acid metabolism affected by SARS CoV 2
Linoleic acid oxylipin metabolism
Lipid metabolism in senescent cells
Lipid metabolism pathway
Lipid particles composition
Liver X receptor pathway
lncRNA in canonical Wnt signaling and colorectal cancer
lncRNA mediated mechanisms of therapeutic resistance
LTF danger signal response pathway
Lung fibrosis
Lung pathology of COVID 19
Macrophage markers
Macrophage stimulating protein MSP signaling
Major receptors targeted by epinephrine and norepinephrine
Malate aspartate shuttle
Male infertility
Male steroid hormones in cardiomyocyte energy metabolism
Mammalian disorder of sexual development
Mammary gland development pathway Embryonic development Stage 1 of 4
Mammary gland development pathway Involution Stage 4 of 4
Mammary gland development pathway Puberty Stage 2 of 4
Mammary gland development pregnancy and lactation stage 3 of 4
MAP3K1 role in promoting and blocking gonadal determination
MAPK and NFkB signaling inhibited by Yersinia YopJ
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
MAPK pathway in congenital thyroid cancer
MAPK signaling
Markers of kidney cell lineage
Matrix metalloproteinases disease cluster belonging to disease group cardiovascular
mBDNF and proBDNF regulation of GABA neurotransmission
Measles virus infection
Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms
MECP2 and associated Rett syndrome
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)|A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain.
Melatonin metabolism and effects
Mesodermal commitment pathway
MET in type 1 papillary renal cell carcinoma
Metabolic epileptic disorders
Metabolic pathway of LDL HDL and TG including diseases
Metabolic pathways of fibroblasts
Metabolic reprogramming in colon cancer
Metabolic reprogramming in pancreatic cancer
Metabolism of alpha linolenic acid
Metabolism of dichloroethylene by CYP450
Metabolism of sphingolipids in ER and Golgi apparatus
Metabolism of tetrahydrocannabinol THC
Metapathway biotransformation Phase I and II
Metastatic brain tumor
Methionine de novo and salvage pathway
Methionine metabolism leading to sulfur amino acids and related disorders
Methylation pathways
Mevalonate arm of cholesterol biosynthesis pathway
Mevalonate arm of cholesterol biosynthesis pathway with inhibitors
Mevalonate pathway
MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement
MFAP5 mediated ovarian cancer cell motility and invasiveness
Microglia pathogen phagocytosis pathway
MicroRNA for targeting cancer growth and vascularization in glioblastoma
MicroRNA network associated with chronic lymphocytic leukemia
MicroRNAs in cardiomyocyte hypertrophy
Microtubule cytoskeleton regulation
Mineralocorticoid biosynthesis
mir 124 predicted interactions with cell cycle and differentiation
miR 222 in exercise induced cardiac growth
miR 509 3p alteration of YAP1 ECM axis
miR 517 relationship with ARCN1 and USP1
miRNA biogenesis
miRNA degrading enzymes
miRNA regulation of DNA damage response
miRNA regulation of p53 pathway in prostate cancer
miRNA regulation of prostate cancer signaling
miRNA role in immune response in sepsis
miRNA targets in ECM and membrane receptors
miRNAs involved in DNA damage response
Mitochondrial beta oxidation
Mitochondrial complex I assembly model OXPHOS system
Mitochondrial complex II assembly
Mitochondrial complex III assembly
Mitochondrial complex IV assembly
Mitochondrial fatty acid oxidation disorders
Mitochondrial fatty acid synthesis pathway
Mitochondrial fission and fusion
Mitochondrial gene expression
Mitochondrial immune response to SARS CoV 2
Mitochondrial long chain fatty acid beta oxidation
Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors
Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids
Modulators of TCR signaling and T cell activation
Molybdenum cofactor Moco biosynthesis
Monoamine GPCRs
Monoamine transport The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
mRNA protein and metabolite inducation pathway by cyclosporin A
mRNA vaccine activation of dendritic cell and induction of IFN 1
MTHFR deficiency
Multiple epiphyseal dysplasia and pseudoachondroplasia genes
MYD88 distinct input output pathway
Myometrial relaxation and contraction pathways
N glycan biosynthesis
NAD biosynthesis II from tryptophan
NAD biosynthetic pathways
NAD metabolism
NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence
NAD metabolism sirtuins and aging
Nanomaterial induced apoptosis
Nanomaterial induced inflammasome activation
Nanoparticle mediated activation of receptor signaling
Nanoparticle triggered autophagic cell death
Nanoparticle triggered regulated necrosis
ncRNAs in Wnt signaling in hepatocellular carcinoma
ncRNAs involved in STAT3 signaling in hepatocellular carcinoma
Neolacto series sphingolipid metabolism
Neovascularization processes
Nephrogenesis
Nephrotic syndrome Xref MGI.
Nephrotoxcicity adverse outcome pathway
Netrin UNC5B signaling
Network map of SARS CoV 2 signaling
Neural crest cell migration during development
Neural crest cell migration in cancer
Neural crest differentiation
Neurodegeneration with brain iron accumulation NBIA subtypes pathway
Neurogenesis regulation in the olfactory epithelium
Neuroinflammation
Neuroinflammation and glutamatergic signaling
Neurotransmitter disorders
NF1 copy number variation syndrome
Nicotine effect on chromaffin cells
Nicotine effect on dopaminergic neurons
Nicotine metabolism in liver cells
NIPBL role in DNA damage Cornelia de Lange syndrome
Nitric oxide metabolism in cystic fibrosis
NO cGMP PKG mediated neuroprotection
Nod like receptor NLR signaling
Non classical role of vitamin D
Non genomic actions of 1 25 dihydroxyvitamin D3
Non homologous end joining
Non small cell lung cancer
Nonalcoholic fatty liver disease
Notch signaling
NOTCH1 regulation of endothelial cell calcification
Novel intracellular components of RIG I like receptor pathway
NPHP1 deletion syndrome
NRF2 ARE regulation
NRF2 pathway
NRP1 triggered signaling in pancreatic cancer
NRXN1 deletion syndrome
nsp1 from SARS CoV 2 inhibits translation initiation in the host cell
Nuclear receptors
Nuclear receptors in lipid metabolism and toxicity
Nuclear receptors meta pathway
Nucleotide binding oligomerization domain NOD pathway
Nucleotide excision repair disease cluster belonging to disease group other
Nucleotide excision repair in xeroderma pigmentosum
Nucleotide GPCRs
Octadecanoid formation from linoleic acid
Oligodendrocyte specification and differentiation leading to myelin components for CNS
Omega 3 omega 6 fatty acid synthesis
Omega 6 fatty acids in senescence
Omega 9 fatty acid synthesis
Oncostatin M signaling
One carbon metabolism
Opioid receptor pathways
Orexin receptor pathway
Osteoarthritic chondrocyte hypertrophy
Osteoblast differentiation and related diseases
Osteoblast signaling
Osteoclast signaling
Osteopontin signaling
OSX and miRNAs in tooth development
Ovarian infertility
Overlap between signal transduction pathways contributing to LMNA laminopathies
Overview of nanoparticle effects
Overview of proinflammatory and profibrotic mediators
Oxidation by cytochrome P450
Oxidative damage response
Oxidative phosphorylation The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
Oxidative stress response
Oxysterols derived from cholesterol
Oxytocin signaling
p38 MAPK signaling
p53 transcriptional gene network
PAFAH1B1 copy number variation
Pancreatic adenocarcinoma pathway
Pancreatic cancer subtypes
Parkin ubiquitin proteasomal system pathway
Parkinson 39 s disease pathway
Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex
Pathogenic Escherichia coli infection
Pathophysiological roles of DUX4 in FSHD1
Pathways affected in adenoid cystic carcinoma
Pathways of nucleic acid metabolism and innate immune sensing
PCSK9 mediated LDL receptor degradation
PDGF pathway
PDGFR beta pathway
Pentose phosphate metabolism
Pentose phosphate pathway in senescent cells
Peptide GPCRs
Peroxiredoxin 2 induced ovarian failure
Peroxisomal beta oxidation of tetracosanoyl CoA
Perturbations to host cell autophagy induced by SARS CoV 2 proteins
PGK1 PKM2 KHKC KHKA acting as protein kinases
Phase I biotransformations non P450
Phosphatidyl inositol phosphate pathway
Phosphodiesterases in neuronal function
Phosphoinositides metabolism
Photodynamic therapy induced AP 1 survival signaling
Photodynamic therapy induced HIF 1 survival signaling
Photodynamic therapy induced NF kB survival signaling
Photodynamic therapy induced NFE2L2 NRF2 survival signaling
Photodynamic therapy induced unfolded protein response
Physico chemical features and toxicity associated pathways
Physiological and pathological hypertrophy of the heart
PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer
PI3K AKT mTOR vitamin D3 signaling
PI3K Akt signaling
Pilocytic astrocytoma An astrocytoma that is characterized by cells that look like fibers when viewed under a microscope and is located_in the brain.
PKC gamma calcium signaling in ataxia
Platelet mediated interactions with vascular and circulating cells
Pleural mesothelioma A Malignant mesothelioma originating from cells of the pleura (the thin layer of mesothelium lining the lungs). Pleural mesothelioma is the most common form of mesothelioma.
Pluripotent stem cell differentiation pathway
Polycystic kidney disease pathway
Polyol pathway
Post COVID neuroinflammation
PPAR alpha pathway
PPAR signaling
Prader Willi and Angelman syndrome
Pre implantation embryo
Pregnane X receptor pathway
Primary focal segmental glomerulosclerosis FSGS
Primary ovarian insufficiency
Prion disease pathway
Pro survival signaling of neuroprotectin D1
Progeria associated lipodystrophy
Prolactin signaling
Proline and hydroxyproline pathways
Prostaglandin and leukotriene metabolism in senescence
Prostaglandin signaling
Prostaglandin synthesis and regulation
Proteasome degradation
Proteoglycan biosynthesis
Proximal tubule transport
PtdIns 4 5 P2 in cytokinesis pathway
PTF1A related regulatory pathway
Purine metabolism
Purine metabolism and related disorders
Purinergic signaling
Pyrimidine metabolism and related diseases
Quercetin and Nf kB AP 1 induced apoptosis
RAC1 PAK1 p38 MMP2 pathway
RalA downstream regulated genes
RANKL RANK signaling
RAS and bradykinin pathways in COVID 19
Ras signaling
Regucalcin in proximal tubule epithelial kidney cells
Regulation of actin cytoskeleton
Regulation of apoptosis by parathyroid hormone related protein
Regulation of sister chromatid separation at the metaphase anaphase transition
Regulation of Wnt B catenin signaling by small molecule compounds
Regulatory circuits of STAT3 signaling
Relationship between inflammation COX 2 and EGFR
Relevant molecular pathways and targeted agents in triple negative breast cancer
Renin angiotensin aldosterone system RAAS
Resistin as a regulator of inflammation
Resolvin E1 and resolvin D1 signaling decrease inflammation
Retinoblastoma gene in cancer
Rett syndrome A pervasive developmental disease that is a neurological and developmental disorder that mostly occurs in females and is caused_by a mutation on the MECP2 gene on the X chromosome. Infants with Rett syndrome seem to grow and develop normally at first, but then stop developing and even lose skills and abilities.
Riboflavin and CoQ disorders
RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis
ROBO4 and VEGF signaling crosstalk
Roles of ceramides in development of insulin resistance
ROS in COVID 19 endothelial dysfunction
Rubinstein Taybi syndrome 1
S1P receptor signal transduction
SARS coronavirus and innate immunity
SARS CoV 2 altering angiogenesis via NRP1
SARS CoV 2 and ACE2 receptor molecular mechanisms
SARS CoV 2 and COVID 19 pathway
SARS CoV 2 B 1 1 7 variant antagonises innate immune activation
SARS CoV 2 innate immunity evasion and cell specific immune response
SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction
SARS CoV 2 replication organelle formation
SCFA and skeletal muscle substrate metabolism
Sebaleic acid formation and metabolism
Selective expression of chemokine receptors during T cell polarization
Selenium metabolism and selenoproteins
Selenium micronutrient network
Senescence associated secretory phenotype SASP
Serine metabolism
Serotonin and anxiety
Serotonin and anxiety related events
Serotonin HTR1 group and FOS pathway
Serotonin receptor 2 and ELK SRF GATA4 signaling
Serotonin receptor 4 6 7 and NR3C signaling
Serotonin transporter activity
Signal transduction through IL1R
Sildenafil treatment
Sleep regulation
Small cell lung cancer
Small ligand GPCRs
SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome
Smith Magenis and Potocki Lupski syndrome copy number variation
Soluble ACE2 mediated cell entry of SARS CoV 2
Somatic sex determination The determination of sex and sexual phenotypes in an organism's soma.
Somatroph axis GH and its relationship to dietary restriction and aging
Somitogenesis in the context of spondylocostal dysostosis
Sphingolipid metabolism in senescence
Sphingolipid metabolism integrated pathway
Sphingolipid metabolism overview
Sphingolipid pathway
Spina bifida
Spinal cord injury
Splicing factor NOVA regulated synaptic proteins
SREBF and miR33 in cholesterol and lipid homeostasis
SRF and miRs in smooth muscle differentiation and proliferation
Statin inhibition of cholesterol production
Steroid biosynthesis
Steroid hormone precursor biosynthesis
Sterol regulatory element binding proteins SREBP signaling
STING pathway in Kawasaki like disease and COVID 19
Striated muscle contraction pathway
Sudden infant death syndrome SIDS susceptibility pathways
Sulfatase and aromatase pathway
Sulfation biotransformation reaction
Sulindac metabolic pathway
Suppression of HMGB1 mediated inflammation by THBD
Synaptic signaling associated with autism spectrum disorder
Synaptic vesicle pathway
Synthesis of ceramides and 1 deoxyceramides
T cell activation SARS CoV 2
T cell antigen receptor TCR pathway during Staphylococcus aureus infection
T cell modulation in pancreatic cancer
T cell receptor and co stimulatory signaling
T cell receptor signaling
Tamoxifen metabolism
TAR syndrome
Target of rapamycin signaling
TCA cycle aka Krebs or citric acid cycle
TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc
TCA cycle in senescence
TCA cycle nutrient use and invasiveness of ovarian cancer
TGF beta receptor signaling
TGF beta receptor signaling in skeletal dysplasias
TGF beta signaling in thyroid cells for epithelial mesenchymal transition
TGF beta signaling pathway
TGFB Smad signaling
Tgif disruption of Shh signaling
Th17 cell differentiation pathway
Thermogenesis
Thiamine metabolic pathways
Thymic stromal lymphopoietin TSLP signaling
Thyroid hormones production and peripheral downstream signaling effects
Thyroid stimulating hormone TSH signaling
Thyroxine thyroid hormone production
TLR4 signaling and tolerance
TNF alpha signaling
TNF related weak inducer of apoptosis TWEAK signaling
Toll like receptor signaling
Toll like receptor signaling related to MyD88
TP53 network
Trans sulfuration one carbon metabolism and related pathways
Trans sulfuration pathway
Transcription co factors SKI and SKIL protein partners
Transcription factor regulation in adipogenesis
Transcription factors regulate miRNAs related to cardiac hypertrophy
Transcriptional activation by NRF2 in response to phytochemicals
Transcriptional cascade regulating adipogenesis
Translation factors
Translation inhibitors in chronically activated PDGFRA cells
Triacylglyceride synthesis
TROP2 regulatory signaling
Tryptophan catabolism leading to NAD production
Tryptophan metabolism
Tumor suppressor activity of SMARCB1
Type 2 papillary renal cell carcinoma
Type I collagen synthesis in the context of osteogenesis imperfecta
Type I interferon induction and signaling during SARS CoV 2 infection
Type II diabetes mellitus A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.|A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.
Type II interferon signaling
Type III interferon signaling
TYROBP causal network in microglia
Tyrosine metabolism and related disorders
UDP derived sugars synthesis in fibroblasts
Ulcerative colitis signaling
Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer
Unfolded protein response
Urea cycle and associated pathways
Urea cycle and metabolism of amino groups
Urea cycle and related diseases
Urotensin II mediated signaling
Valproic acid pathway
Vasopressin regulated water reabsorption
VEGFA VEGFR2 signaling
Vitamin A and carotenoid metabolism
Vitamin A1 and A5 X pathways
Vitamin B12 disorders
Vitamin B12 metabolism
Vitamin B6 dependent and responsive disorders
Vitamin D in inflammatory diseases
Vitamin D metabolism
Vitamin D receptor pathway
Vitamin D sensitive calcium signaling in depression
Vitamin K metabolism and activation of dependent proteins
Vitamins A and D action mechanisms
Warburg effect modulated by deubiquitinating enzymes and their substrates
White fat cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole.
Wnt beta catenin signaling in leukemia
Wnt Beta catenin signaling inhibitors in current and past clinical trials
Wnt signaling
Wnt signaling and pluripotency
Wnt signaling in kidney disease
Zinc homeostasis