880 sets of proteins participating in pathways from the WikiPathways Pathways 2024 dataset.
Gene Set |
Description |
10q11 21q11 23 copy number variation syndrome
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10q22q23 copy number variation
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11p11 2 copy number variation syndrome
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13q12 12 copy number variation
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13q12 or CRYL1 copy number variation
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15q11 2 copy number variation syndrome
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15q11q13 copy number variation
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15q13 3 copy number variation syndrome
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15q25 copy number variation
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16p11 2 distal deletion syndrome
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16p11 2 proximal deletion syndrome
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17p13 3 YWHAE copy number variation
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17q12 copy number variation syndrome
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1p36 copy number variation syndrome
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1q21 1 copy number variation syndrome
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22q11 2 copy number variation syndrome
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2q11 2 copy number variation syndrome
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2q13 copy number variation syndrome
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2q21 1 copy number variation syndrome
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2q37 copy number variation syndrome
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3q29 copy number variation syndrome
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4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression
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4p16 3 copy number variation
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5q35 copy number variation
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6q16 copy number variation
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7 oxo C and 7 beta HC pathways
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7q11 23 copy number variation syndrome
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7q11 23 distal copy number variation
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8p23 1 copy number variation syndrome
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8q11 23 RB1CC1 copy number variation
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Abnormal calcium handling and its effects on muscle contraction in DMD
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ACE inhibitor pathway
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Acetaminophen in analgesia and antipyresis
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Acetylcholine synthesis
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Acquired partial lipodystrophy Barraquer Simons syndrome
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Acrylamide biotransformation and exposure biomarkers
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Activation of NLRP3 inflammasome by SARS CoV 2
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Acute myeloid leukemia
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Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
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Acute viral myocarditis
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ADHD and autism ASD pathways
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Adipogenesis
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Aerobic glycolysis
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Aerobic glycolysis augmented
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Affected pathways in Duchenne muscular dystrophy
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Aflatoxin B1 metabolism
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AGE RAGE pathway
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Airway smooth muscle cell contraction
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ALA oxylipin metabolism
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Alanine and aspartate metabolism
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Allograft rejection
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Alpha 6 beta 4 signaling
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Alstrom syndrome
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An autosomal recessive disease that is characterized by multiorgan dysfunction. The key features are childhood obesity, blindness due to congenital retinal dystrophy, and sensorineural hearing loss with autosomal recessive inheritance and has_material_basis_in mutations in the ALMS1 gene.
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Altered glycosylation of MUC1 in tumor microenvironment
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Alternative pathway of fetal androgen synthesis
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Alzheimer 39 s disease
|
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Alzheimer 39 s disease and miRNA effects
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Amino acid conjugation of benzoic acid
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Amino acid metabolism
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Amino acid metabolism in triple negative breast cancer cells
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Amino acid metabolism pathway excerpt histidine catabolism extension
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Amino acid transport defects IEMs
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AMP activated protein kinase signaling
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Amplification and expansion of oncogenic pathways as metastatic traits
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Amyotrophic lateral sclerosis ALS
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Androgen receptor network in prostate cancer
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Androgen receptor signaling
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Angiogenesis
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Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
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Angiopoietin like protein 8 regulatory pathway
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Angiotensin II receptor type 1 pathway
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Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway
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ApoE and miR 146 in inflammation and atherosclerosis
|
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Apoptosis
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Apoptosis modulation and signaling
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Apoptosis modulation by HSP70
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Apoptosis related network due to altered Notch3 in ovarian cancer
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Arachidonate epoxygenase epoxide hydrolase
|
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Arachidonic acid AA ARA oxylipin metabolism
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Aripiprazole metabolic pathway
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Arrhythmogenic right ventricular cardiomyopathy
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An intrinsic cardiomyopathy that is characterized by hypokinetic areas involving the free wall of the right ventricle, with fibrofatty replacement of the right ventricular myocardium, with associated arrhythmias originating in the right ventricle.
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Arsenic metabolism and reactive oxygen species generation
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Artemisinin inhibition of uveal melanoma
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Aryl hydrocarbon receptor pathway
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Arylamine metabolism
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Aspirin and miRNAs
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ATM signaling
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ATM signaling in development and disease
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ATR signaling
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Autophagy
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The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
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Autophagy in pancreatic ductal adenocarcinoma
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Autosomal recessive osteopetrosis pathways
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Axon guidance
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The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
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B cell receptor signaling
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Bardet Biedl syndrome
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Base excision repair
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BDNF TrkB signaling
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Benzene metabolism
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Benzo a pyrene metabolism
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Bile acid synthesis and enterohepatic circulation
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Biogenic amine synthesis
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Biomarkers for pyrimidine metabolism disorders
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Biomarkers for urea cycle disorders
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Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine
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Biosynthesis and turnover of 1 deoxy sphingoid bases
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Biotin metabolism including IMDs
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Bladder cancer
|
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Blood clotting cascade
|
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BMP signaling in eyelid development
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BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation
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Bone morphogenic protein signaling and regulation
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Brain derived neurotrophic factor BDNF signaling
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Breast cancer pathway
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Burn wound healing
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Butyrate induced histone acetylation
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Caffeine and theobromine metabolism
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Calcium mediated T cell apoptosis involved in inclusion body myositis
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Calcium regulation in cardiac cells
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Caloric restriction and aging
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CAMKK2 pathway
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Cancer immunotherapy by CTLA4 blockade
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Cancer immunotherapy by PD 1 blockade
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Cancer pathways
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Cannabinoid receptor signaling
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Canonical and non canonical Notch signaling
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Canonical and non canonical TGF B signaling
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Canonical NF kB pathway
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Cardiac hypertrophic response
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Cardiac progenitor differentiation
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Cardiomyocyte signaling converging on titin
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Carnosine metabolism of glial cells
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Catabolism of skeletal muscle in cachexia
|
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Catalytic cycle of mammalian flavin containing monooxygenases FMOs
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CCL18 signaling
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Cell cycle
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The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
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Cell differentiation expanded index
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Cell differentiation index
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Cell interactions of the pancreatic cancer microenvironment
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Cell lineage map for neuronal differentiation
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Cell type dependent selectivity of CCK2R signaling
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Cells and molecules involved in local acute inflammatory response
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Cellular proteostasis
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Cerebral organic acidurias including diseases
|
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Chemokine signaling
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Cholestasis
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Cholesterol biosynthesis pathway
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Cholesterol biosynthesis pathway in hepatocytes
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Cholesterol biosynthesis with skeletal dysplasias
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Cholesterol metabolism
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Cholesterol metabolism with Bloch and Kandutsch Russell pathways
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Cholesterol synthesis disorders
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Chromosomal and microsatellite instability in colorectal cancer
|
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Chronic hyperglycemia impairment of neuron function
|
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Ciliary landscape
|
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Ciliopathies
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Circadian rhythm genes
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Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism
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Clear cell renal cell carcinoma pathways
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Clock controlled autophagy in bone metabolism
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Cocaine metabolism
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Codeine and morphine metabolism
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Cohesin complex Cornelia de Lange syndrome
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Colchicine metabolic pathway
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Common pathways underlying drug addiction
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Complement activation
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Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
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Complement and coagulation cascades
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Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway
|
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Complement system
|
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Complement system in neuronal development and plasticity
|
|
Congenital generalized lipodystrophy
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OMIM mapping confirmed by DO. [SN].
|
Constitutive androstane receptor pathway
|
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Control of immune tolerance by vasoactive intestinal peptide
|
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Conversion of angiotensinogen to angiotensin II
|
|
Copper homeostasis
|
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Copper metabolism
|
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Cori cycle
|
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Corticotropin releasing hormone signaling
|
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COVID 19 adverse outcome pathway
|
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COVID 19 and endothelial cell senescence
|
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COVID 19 structural coverage map
|
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COVID 19 thrombosis and anticoagulation
|
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Creatine pathway
|
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Cysteine and methionine catabolism
|
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Cytokine cytokine receptor interaction
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Cytokines and inflammatory response
|
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Cytoplasmic ribosomal proteins
|
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Cytosine methylation
|
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Cytosolic DNA sensing pathway
|
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DDX1 as a regulatory component of the Drosha microprocessor
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Degradation pathway of sphingolipids including diseases
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Dengue 2 interactions with complement and coagulation cascades
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Deregulation of Rab and Rab effector genes in bladder cancer
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Development and heterogeneity of the ILC family
|
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Development of pulmonary dendritic cells and macrophage subsets
|
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Development of ureteric derived collecting system
|
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Diclofenac metabolic pathway
|
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Diet dependent trimethylamine trimethylamine N oxide metabolism
|
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Differentiation of white and brown adipocyte
|
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Direct reversal repair
|
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Disorders in ketolysis
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Disorders in ketone body synthesis
|
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Disorders of bile acid synthesis and biliary transport
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Disorders of folate metabolism and transport
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Disorders of fructose metabolism
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Disorders of galactose metabolism
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Disruption of postsynaptic signaling by CNV
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DNA damage response
|
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DNA damage response only ATM dependent
|
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DNA IR damage and cellular response via ATR
|
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DNA IR double strand breaks and cellular response via ATM
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DNA mismatch repair
|
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DNA repair pathways full network
|
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DNA replication
|
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
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Docosahexaenoic acid oxylipin metabolism
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Dopamine metabolism
|
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Dopaminergic neurogenesis
|
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Downregulation of ACE2 by SARS CoV 2 spike protein
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Dravet syndrome
|
An epilepsy that is characterized by frequent febrile seizures with onset before 1 year.
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Drug induction of bile acid pathway
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Dual hijack model of Vif in HIV infection
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DYRK1A involvement regarding cell proliferation in brain development
|
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Ebola virus infection in host
|
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Ebstein Barr virus LMP1 signaling
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Ectoderm differentiation
|
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EDA signaling in hair follicle development
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Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists
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Effect of omega 3 PUFA on Huntington 39 s disease pathways
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Effect of progerin on genes involved in progeria
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Effects of MFN2 mutation
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Effects of nitric oxide
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EGF EGFR signaling
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EGFR tyrosine kinase inhibitor resistance
|
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Eicosanoid metabolism via cyclooxygenases COX
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Eicosanoid metabolism via cytochrome P450 monooxygenases pathway
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Eicosanoid metabolism via lipooxygenases LOX
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Eicosanoid synthesis
|
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eIF5A regulation in response to inhibition of the nuclear export system
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Electron transport chain OXPHOS system in mitochondria
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Embryonic stem cell pluripotency pathways
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Endochondral ossification
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Replacement ossification wherein bone tissue replaces cartilage.
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Endochondral ossification with skeletal dysplasias
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Endoderm differentiation
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Endometrial cancer
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A uterine cancer that is located_in tissues lining the uterus.
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Endoplasmic reticulum stress response in coronavirus infection
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Endothelin pathways
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Energy metabolism
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Enterocyte cholesterol metabolism
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Enterohepatic circulation of bile acids
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Envelope proteins and their potential roles in EDMD physiopathology
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EPAC1 and PKA reduction of retinal inflammation
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Epithelial to mesenchymal transition in colorectal cancer
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EPO receptor signaling
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ErbB signaling
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ERK pathway in Huntington 39 s disease
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Estradiol regulation in porto sinusoidal vascular disease
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Estrogen metabolism
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Estrogen receptor pathway
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Estrogen signaling
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Ethanol effects on histone modifications
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Ethanol metabolism production of ROS by CYP2E1
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Ether lipid biosynthesis
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Ethylmalonic encephalopathy
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Eukaryotic transcription initiation
|
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EV release from cardiac cells and their functional effects
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Evolocumab mechanism to reduce LDL cholesterol
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Exercise induced circadian regulation
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exRNA mechanism of action and biogenesis
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Extracellular vesicle mediated signaling in recipient cells
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Extracellular vesicles in the crosstalk of cardiac cells
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Extrafollicular and follicular B cell activation by SARS CoV 2
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FABP4 in ovarian cancer
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Factors and pathways affecting insulin like growth factor IGF1 Akt signaling
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Familial hyperlipidemia type 1
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Familial hyperlipidemia type 2
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Familial hyperlipidemia type 3
|
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Familial hyperlipidemia type 4
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Familial hyperlipidemia type 5
|
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Familial partial lipodystrophy
|
A lipodystrophy characterized by abnormal subcutaneous adipose tissue distribution beginning in late childhood or early adult life.
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Farnesoid X receptor pathway
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Fas ligand pathway and stress induction of heat shock proteins
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Fatty acid beta oxidation
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Fatty acid biosynthesis
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Fatty acid omega oxidation
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Fatty acid transporters
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Fatty acids and lipoproteins transport in hepatocytes
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FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma
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Felbamate metabolism
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Female steroid hormones in cardiomyocyte energy metabolism
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Ferroptosis
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FGF23 signaling in hypophosphatemic rickets and related disorders
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FGFR3 signaling in chondrocyte proliferation and terminal differentiation
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FGFR4 p G388R signaling
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Fibrin complement receptor 3 signaling
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Flavan 3 ol metabolic pathway
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FLT3 p Gln640SerfsTer8 signaling
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Fluoroacetic acid toxicity
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Fluoropyrimidine activity
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Focal adhesion
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Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
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Focal adhesion PI3K Akt mTOR signaling
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Folate alcohol and cancer pathway hypotheses
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Folate metabolism
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Follicle stimulating hormone FSH signaling
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FOXA2 pathway
|
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FOXP3 in COVID 19
|
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Fragile X syndrome
|
A neurodegenerative disease that is characterized by moderate to severe mental retardation, macroorchidism, and distinct facial features, including long face, large ears, and prominent jaw, and has_material_basis_in a loss of FMR1 function.
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FTO obesity variant mechanism
|
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G protein signaling
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G1 to S cell cycle control
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G13 signaling
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GABA metabolism aka GHB
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GABA receptor signaling
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Galanin receptor pathway
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Gamma glutamyl cycle for the biosynthesis and degradation of glutathione including diseases
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Ganglio series sphingolipid metabolism
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Ganglio sphingolipid metabolism
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Gastric acid production
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Gastric cancer network 1
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Gastric cancer network 2
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Gastrin signaling
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GDNF RET signaling axis
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GDNF signaling
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Gene regulatory network modeling somitogenesis
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Genes associated with the development of rheumatoid arthritis
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Genes controlling nephrogenesis
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Genes related to primary cilium development based on CRISPR
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Genes targeted by miRNAs in adipocytes
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Genetic causes of porto sinusoidal vascular disease
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Glial cell differentiation
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The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.
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Glioblastoma signaling
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GLP 1 from intestine and pancreas and role in glucose homeostasis
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GLP 1 in pancreatic islet cells
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GLP 1 secretion from intestine to portal vein
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Glucocorticoid biosynthesis
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Glucocorticoid receptor pathway
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Glucose homeostasis
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Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
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Glucose metabolism in triple negative breast cancer cells
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Glucuronidation
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Glutathione metabolism
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Glycerolipids and glycerophospholipids
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Glycerophospholipid biosynthetic pathway
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Glycine metabolism
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Glycine metabolism including IMDs
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Glycogen synthesis and degradation
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Glycolysis and gluconeogenesis
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Glycolysis in senescence
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Glycosaminoglycan degradation
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Glycosaminoglycan synthesis in fibroblasts
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Glycosphingolipid metabolism
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Glycosylation and related congenital defects
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Glyoxylate metabolism
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GNAQ pathways in port wine stain
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GPCRs class A rhodopsin like
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GPCRs class B secretin like
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GPCRs class C metabotropic glutamate pheromone
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GPCRs other
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GPR143 in melanocytes and retinal pigment epithelium cells
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GPR40 pathway
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Growth factors and hormones in beta cell proliferation
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Gut liver indole metabolism
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H19 Rb E2F1 and CDK beta catenin in colorectal cancer
|
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Hair follicle development cytodifferentiation stage 3 of 3
|
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Hair follicle development organogenesis part 2 of 3
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HDAC6 interactions in the central nervous system
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Head and neck squamous cell carcinoma
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A squamous cell carcinoma that arises from any of the following anatomic sites: lip and oral cavity, nasal cavity, paranasal sinuses, pharynx, larynx, and salivary glands.|A carcinoma of any tissue within the head and neck region.
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Heart development
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The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
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Hedgehog signaling
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Hematopoietic stem cell differentiation
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The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
|
Hematopoietic stem cell gene regulation by GABP alpha beta complex
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Heme biosynthesis
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Hemesynthesis defects and porphyrias
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Hepatitis B infection
|
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Hepatitis C and hepatocellular carcinoma
|
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Hepatocyte growth factor receptor signaling
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Hereditary leiomyomatosis and renal cell carcinoma pathway
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Heroin metabolism
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Hfe effect on hepcidin production
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HIF1A and PPARG in cardiac hypertropthy
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Hijack of ubiquitination by SARS CoV 2
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HIPK2 in kidney fibrosis
|
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Hippo Merlin signaling dysregulation
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Hippo signaling regulation
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Hippo YAP signaling
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Hippocampal synaptogenesis and neurogenesis
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Histone modifications
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Homologous recombination
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Hormonal control of pubertal growth spurt
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Host pathogen interaction of human coronaviruses apoptosis
|
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Host pathogen interaction of human coronaviruses autophagy
|
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Host pathogen interaction of human coronaviruses interferon induction
|
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Host pathogen interaction of human coronaviruses MAPK signaling
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Hunger and satiety
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disease cluster belonging to disease group metabolic
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Hypertrophy model
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Hypothesized pathways in pathogenesis of cardiovascular disease
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Hypothetical craniofacial development pathway
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Hypoxia mediated EMT and stemness
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ID signaling
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IDO metabolic pathway
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IL1 and megakaryocytes in obesity
|
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IL1 signaling
|
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IL10 anti inflammatory signaling
|
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IL11 signaling
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IL17 signaling
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IL18 signaling
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IL19 signaling
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IL2 signaling
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IL26 signaling
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IL3 signaling
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IL4 signaling
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IL5 signaling
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IL6 signaling
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IL7 signaling
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IL9 signaling
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Imatinib and chronic myeloid leukemia
|
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Immune infiltration in pancreatic cancer
|
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Immune response to tuberculosis
|
|
Inclusion body myositis
|
A myositis that is characterized by slowly progressive weakness and wasting of both distal and proximal muscles, most apparent in the muscles of the arms and legs that can occur in a sporadic or hereditary forms.
|
Induction of autophagy and toll like receptor signaling by graphene oxide
|
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Inflammatory bowel disease signaling
|
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Inflammatory response pathway
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Influence of laminopathies on Wnt signaling
|
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Influenza A virus infection
|
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Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells
|
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Initiation of transcription and translation elongation at the HIV 1 LTR
|
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Insulin signaling
|
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Insulin signaling in adipocytes diabetic condition
|
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Insulin signaling in adipocytes normal condition
|
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Integrated cancer pathway
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Integrin mediated cell adhesion
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Interactions between immune cells and microRNAs in tumor microenvironment
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Interactions between LOXL4 and oxidative stress pathway
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Interactions of natural killer cells in pancreatic cancer
|
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Interactome of polycomb repressive complex 2 PRC2
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Interferon mediated signaling
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Interferon type I signaling
|
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Interleukin 1 IL 1 structural pathway
|
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Interleukin 1 induced activation of NF kB
|
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Intracellular trafficking proteins involved in CMT neuropathy
|
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Intraflagellar transport proteins binding to dynein
|
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Involvement of secretase in neurodegenerative diseases
|
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Irinotecan pathway
|
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Iron metabolism disorders
|
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Iron metabolism in placenta
|
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Iron sulfur cluster biogenesis
|
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Isoglobo series sphingolipids
|
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JAK STAT signaling in the regulation of beta cells
|
|
Joubert syndrome
|
An autosomal recessive disease that is characterized by congenital malformation of the brainstem and agenesis or hypoplasia of the cerebellar vermis leading to an abnormal respiratory pattern, nystagmus, hypotonia, ataxia, and delay in achieving motor milestones resulting from dysfunction of ciliary proteins (ciliopathy).
|
Kallmann syndrome
|
OMIM mapping confirmed by DO. [SN].
|
KCNQ2 related epilepsies
|
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Kennedy pathway from sphingolipids
|
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Ketogenesis and ketolysis
|
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Kinin Kallikrein pathway
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Kisspeptin kisspeptin receptor system in the ovary
|
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Kit receptor signaling
|
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Kleefstra syndrome
|
Kleefstra syndrome (KS) is a genetic disorder characterized by intellectual disability, childhood hypotonia, severe expressive speech delay and a distinctive facial appearance with a spectrum of additional clinical features.
|
Krebs cycle disorders
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Kynurenine pathway and links to cell senescence
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Lac Phe pathway
|
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Lactate shuttle in glial cells
|
|
Lacto series sphingolipid metabolism
|
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Lamin A processing pathway
|
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LDL influence on CD14 and TLR4
|
|
LDLRAD4 and what we know about it
|
|
Leptin and adiponectin
|
|
Leptin insulin signaling overlap
|
|
Leptin signaling
|
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let 7 inhibition of ES cell reprogramming
|
|
Leucine isoleucine and valine metabolism
|
|
Leukocyte intrinsic Hippo pathway functions
|
|
Leukotriene metabolic pathway
|
|
Lidocaine metabolism
|
|
Linoleic acid metabolism affected by SARS CoV 2
|
|
Linoleic acid oxylipin metabolism
|
|
Lipid metabolism in senescent cells
|
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Lipid metabolism pathway
|
|
Lipid particles composition
|
|
Liver X receptor pathway
|
|
lncRNA in canonical Wnt signaling and colorectal cancer
|
|
lncRNA mediated mechanisms of therapeutic resistance
|
|
LTF danger signal response pathway
|
|
Lung fibrosis
|
|
Lung pathology of COVID 19
|
|
Macrophage markers
|
|
Macrophage stimulating protein MSP signaling
|
|
Major receptors targeted by epinephrine and norepinephrine
|
|
Malate aspartate shuttle
|
|
Male infertility
|
|
Male steroid hormones in cardiomyocyte energy metabolism
|
|
Mammalian disorder of sexual development
|
|
Mammary gland development pathway Embryonic development Stage 1 of 4
|
|
Mammary gland development pathway Involution Stage 4 of 4
|
|
Mammary gland development pathway Puberty Stage 2 of 4
|
|
Mammary gland development pregnancy and lactation stage 3 of 4
|
|
MAP3K1 role in promoting and blocking gonadal determination
|
|
MAPK and NFkB signaling inhibited by Yersinia YopJ
|
|
MAPK cascade
|
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
|
MAPK pathway in congenital thyroid cancer
|
|
MAPK signaling
|
|
Markers of kidney cell lineage
|
|
Matrix metalloproteinases
|
disease cluster belonging to disease group cardiovascular
|
mBDNF and proBDNF regulation of GABA neurotransmission
|
|
Measles virus infection
|
|
Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms
|
|
MECP2 and associated Rett syndrome
|
|
Melanoma
|
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)|A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain.
|
Melatonin metabolism and effects
|
|
Mesodermal commitment pathway
|
|
MET in type 1 papillary renal cell carcinoma
|
|
Metabolic epileptic disorders
|
|
Metabolic pathway of LDL HDL and TG including diseases
|
|
Metabolic pathways of fibroblasts
|
|
Metabolic reprogramming in colon cancer
|
|
Metabolic reprogramming in pancreatic cancer
|
|
Metabolism of alpha linolenic acid
|
|
Metabolism of dichloroethylene by CYP450
|
|
Metabolism of sphingolipids in ER and Golgi apparatus
|
|
Metabolism of tetrahydrocannabinol THC
|
|
Metapathway biotransformation Phase I and II
|
|
Metastatic brain tumor
|
|
Methionine de novo and salvage pathway
|
|
Methionine metabolism leading to sulfur amino acids and related disorders
|
|
Methylation pathways
|
|
Mevalonate arm of cholesterol biosynthesis pathway
|
|
Mevalonate arm of cholesterol biosynthesis pathway with inhibitors
|
|
Mevalonate pathway
|
|
MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement
|
|
MFAP5 mediated ovarian cancer cell motility and invasiveness
|
|
Microglia pathogen phagocytosis pathway
|
|
MicroRNA for targeting cancer growth and vascularization in glioblastoma
|
|
MicroRNA network associated with chronic lymphocytic leukemia
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Microtubule cytoskeleton regulation
|
|
Mineralocorticoid biosynthesis
|
|
mir 124 predicted interactions with cell cycle and differentiation
|
|
miR 222 in exercise induced cardiac growth
|
|
miR 509 3p alteration of YAP1 ECM axis
|
|
miR 517 relationship with ARCN1 and USP1
|
|
miRNA biogenesis
|
|
miRNA degrading enzymes
|
|
miRNA regulation of DNA damage response
|
|
miRNA regulation of p53 pathway in prostate cancer
|
|
miRNA regulation of prostate cancer signaling
|
|
miRNA role in immune response in sepsis
|
|
miRNA targets in ECM and membrane receptors
|
|
miRNAs involved in DNA damage response
|
|
Mitochondrial beta oxidation
|
|
Mitochondrial complex I assembly model OXPHOS system
|
|
Mitochondrial complex II assembly
|
|
Mitochondrial complex III assembly
|
|
Mitochondrial complex IV assembly
|
|
Mitochondrial fatty acid oxidation disorders
|
|
Mitochondrial fatty acid synthesis pathway
|
|
Mitochondrial fission and fusion
|
|
Mitochondrial gene expression
|
|
Mitochondrial immune response to SARS CoV 2
|
|
Mitochondrial long chain fatty acid beta oxidation
|
|
Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors
|
|
Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids
|
|
Modulators of TCR signaling and T cell activation
|
|
Molybdenum cofactor Moco biosynthesis
|
|
Monoamine GPCRs
|
|
Monoamine transport
|
The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
mRNA processing
|
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
|
mRNA protein and metabolite inducation pathway by cyclosporin A
|
|
mRNA vaccine activation of dendritic cell and induction of IFN 1
|
|
MTHFR deficiency
|
|
Multiple epiphyseal dysplasia and pseudoachondroplasia genes
|
|
MYD88 distinct input output pathway
|
|
Myometrial relaxation and contraction pathways
|
|
N glycan biosynthesis
|
|
NAD biosynthesis II from tryptophan
|
|
NAD biosynthetic pathways
|
|
NAD metabolism
|
|
NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence
|
|
NAD metabolism sirtuins and aging
|
|
Nanomaterial induced apoptosis
|
|
Nanomaterial induced inflammasome activation
|
|
Nanoparticle mediated activation of receptor signaling
|
|
Nanoparticle triggered autophagic cell death
|
|
Nanoparticle triggered regulated necrosis
|
|
ncRNAs in Wnt signaling in hepatocellular carcinoma
|
|
ncRNAs involved in STAT3 signaling in hepatocellular carcinoma
|
|
Neolacto series sphingolipid metabolism
|
|
Neovascularization processes
|
|
Nephrogenesis
|
|
Nephrotic syndrome
|
Xref MGI.
|
Nephrotoxcicity adverse outcome pathway
|
|
Netrin UNC5B signaling
|
|
Network map of SARS CoV 2 signaling
|
|
Neural crest cell migration during development
|
|
Neural crest cell migration in cancer
|
|
Neural crest differentiation
|
|
Neurodegeneration with brain iron accumulation NBIA subtypes pathway
|
|
Neurogenesis regulation in the olfactory epithelium
|
|
Neuroinflammation
|
|
Neuroinflammation and glutamatergic signaling
|
|
Neurotransmitter disorders
|
|
NF1 copy number variation syndrome
|
|
Nicotine effect on chromaffin cells
|
|
Nicotine effect on dopaminergic neurons
|
|
Nicotine metabolism in liver cells
|
|
NIPBL role in DNA damage Cornelia de Lange syndrome
|
|
Nitric oxide metabolism in cystic fibrosis
|
|
NO cGMP PKG mediated neuroprotection
|
|
Nod like receptor NLR signaling
|
|
Non classical role of vitamin D
|
|
Non genomic actions of 1 25 dihydroxyvitamin D3
|
|
Non homologous end joining
|
|
Non small cell lung cancer
|
|
Nonalcoholic fatty liver disease
|
|
Notch signaling
|
|
NOTCH1 regulation of endothelial cell calcification
|
|
Novel intracellular components of RIG I like receptor pathway
|
|
NPHP1 deletion syndrome
|
|
NRF2 ARE regulation
|
|
NRF2 pathway
|
|
NRP1 triggered signaling in pancreatic cancer
|
|
NRXN1 deletion syndrome
|
|
nsp1 from SARS CoV 2 inhibits translation initiation in the host cell
|
|
Nuclear receptors
|
|
Nuclear receptors in lipid metabolism and toxicity
|
|
Nuclear receptors meta pathway
|
|
Nucleotide binding oligomerization domain NOD pathway
|
|
Nucleotide excision repair
|
disease cluster belonging to disease group other
|
Nucleotide excision repair in xeroderma pigmentosum
|
|
Nucleotide GPCRs
|
|
Octadecanoid formation from linoleic acid
|
|
Oligodendrocyte specification and differentiation leading to myelin components for CNS
|
|
Omega 3 omega 6 fatty acid synthesis
|
|
Omega 6 fatty acids in senescence
|
|
Omega 9 fatty acid synthesis
|
|
Oncostatin M signaling
|
|
One carbon metabolism
|
|
Opioid receptor pathways
|
|
Orexin receptor pathway
|
|
Osteoarthritic chondrocyte hypertrophy
|
|
Osteoblast differentiation and related diseases
|
|
Osteoblast signaling
|
|
Osteoclast signaling
|
|
Osteopontin signaling
|
|
OSX and miRNAs in tooth development
|
|
Ovarian infertility
|
|
Overlap between signal transduction pathways contributing to LMNA laminopathies
|
|
Overview of nanoparticle effects
|
|
Overview of proinflammatory and profibrotic mediators
|
|
Oxidation by cytochrome P450
|
|
Oxidative damage response
|
|
Oxidative phosphorylation
|
The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
|
Oxidative stress response
|
|
Oxysterols derived from cholesterol
|
|
Oxytocin signaling
|
|
p38 MAPK signaling
|
|
p53 transcriptional gene network
|
|
PAFAH1B1 copy number variation
|
|
Pancreatic adenocarcinoma pathway
|
|
Pancreatic cancer subtypes
|
|
Parkin ubiquitin proteasomal system pathway
|
|
Parkinson 39 s disease pathway
|
|
Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex
|
|
Pathogenic Escherichia coli infection
|
|
Pathophysiological roles of DUX4 in FSHD1
|
|
Pathways affected in adenoid cystic carcinoma
|
|
Pathways of nucleic acid metabolism and innate immune sensing
|
|
PCSK9 mediated LDL receptor degradation
|
|
PDGF pathway
|
|
PDGFR beta pathway
|
|
Pentose phosphate metabolism
|
|
Pentose phosphate pathway in senescent cells
|
|
Peptide GPCRs
|
|
Peroxiredoxin 2 induced ovarian failure
|
|
Peroxisomal beta oxidation of tetracosanoyl CoA
|
|
Perturbations to host cell autophagy induced by SARS CoV 2 proteins
|
|
PGK1 PKM2 KHKC KHKA acting as protein kinases
|
|
Phase I biotransformations non P450
|
|
Phosphatidyl inositol phosphate pathway
|
|
Phosphodiesterases in neuronal function
|
|
Phosphoinositides metabolism
|
|
Photodynamic therapy induced AP 1 survival signaling
|
|
Photodynamic therapy induced HIF 1 survival signaling
|
|
Photodynamic therapy induced NF kB survival signaling
|
|
Photodynamic therapy induced NFE2L2 NRF2 survival signaling
|
|
Photodynamic therapy induced unfolded protein response
|
|
Physico chemical features and toxicity associated pathways
|
|
Physiological and pathological hypertrophy of the heart
|
|
PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer
|
|
PI3K AKT mTOR vitamin D3 signaling
|
|
PI3K Akt signaling
|
|
Pilocytic astrocytoma
|
An astrocytoma that is characterized by cells that look like fibers when viewed under a microscope and is located_in the brain.
|
PKC gamma calcium signaling in ataxia
|
|
Platelet mediated interactions with vascular and circulating cells
|
|
Pleural mesothelioma
|
A Malignant mesothelioma originating from cells of the pleura (the thin layer of mesothelium lining the lungs). Pleural mesothelioma is the most common form of mesothelioma.
|
Pluripotent stem cell differentiation pathway
|
|
Polycystic kidney disease pathway
|
|
Polyol pathway
|
|
Post COVID neuroinflammation
|
|
PPAR alpha pathway
|
|
PPAR signaling
|
|
Prader Willi and Angelman syndrome
|
|
Pre implantation embryo
|
|
Pregnane X receptor pathway
|
|
Primary focal segmental glomerulosclerosis FSGS
|
|
Primary ovarian insufficiency
|
|
Prion disease pathway
|
|
Pro survival signaling of neuroprotectin D1
|
|
Progeria associated lipodystrophy
|
|
Prolactin signaling
|
|
Proline and hydroxyproline pathways
|
|
Prostaglandin and leukotriene metabolism in senescence
|
|
Prostaglandin signaling
|
|
Prostaglandin synthesis and regulation
|
|
Proteasome degradation
|
|
Proteoglycan biosynthesis
|
|
Proximal tubule transport
|
|
PtdIns 4 5 P2 in cytokinesis pathway
|
|
PTF1A related regulatory pathway
|
|
Purine metabolism
|
|
Purine metabolism and related disorders
|
|
Purinergic signaling
|
|
Pyrimidine metabolism and related diseases
|
|
Quercetin and Nf kB AP 1 induced apoptosis
|
|
RAC1 PAK1 p38 MMP2 pathway
|
|
RalA downstream regulated genes
|
|
RANKL RANK signaling
|
|
RAS and bradykinin pathways in COVID 19
|
|
Ras signaling
|
|
Regucalcin in proximal tubule epithelial kidney cells
|
|
Regulation of actin cytoskeleton
|
|
Regulation of apoptosis by parathyroid hormone related protein
|
|
Regulation of sister chromatid separation at the metaphase anaphase transition
|
|
Regulation of Wnt B catenin signaling by small molecule compounds
|
|
Regulatory circuits of STAT3 signaling
|
|
Relationship between inflammation COX 2 and EGFR
|
|
Relevant molecular pathways and targeted agents in triple negative breast cancer
|
|
Renin angiotensin aldosterone system RAAS
|
|
Resistin as a regulator of inflammation
|
|
Resolvin E1 and resolvin D1 signaling decrease inflammation
|
|
Retinoblastoma gene in cancer
|
|
Rett syndrome
|
A pervasive developmental disease that is a neurological and developmental disorder that mostly occurs in females and is caused_by a mutation on the MECP2 gene on the X chromosome. Infants with Rett syndrome seem to grow and develop normally at first, but then stop developing and even lose skills and abilities.
|
Riboflavin and CoQ disorders
|
|
RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis
|
|
ROBO4 and VEGF signaling crosstalk
|
|
Roles of ceramides in development of insulin resistance
|
|
ROS in COVID 19 endothelial dysfunction
|
|
Rubinstein Taybi syndrome 1
|
|
S1P receptor signal transduction
|
|
SARS coronavirus and innate immunity
|
|
SARS CoV 2 altering angiogenesis via NRP1
|
|
SARS CoV 2 and ACE2 receptor molecular mechanisms
|
|
SARS CoV 2 and COVID 19 pathway
|
|
SARS CoV 2 B 1 1 7 variant antagonises innate immune activation
|
|
SARS CoV 2 innate immunity evasion and cell specific immune response
|
|
SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction
|
|
SARS CoV 2 replication organelle formation
|
|
SCFA and skeletal muscle substrate metabolism
|
|
Sebaleic acid formation and metabolism
|
|
Selective expression of chemokine receptors during T cell polarization
|
|
Selenium metabolism and selenoproteins
|
|
Selenium micronutrient network
|
|
Senescence associated secretory phenotype SASP
|
|
Serine metabolism
|
|
Serotonin and anxiety
|
|
Serotonin and anxiety related events
|
|
Serotonin HTR1 group and FOS pathway
|
|
Serotonin receptor 2 and ELK SRF GATA4 signaling
|
|
Serotonin receptor 4 6 7 and NR3C signaling
|
|
Serotonin transporter activity
|
|
Signal transduction through IL1R
|
|
Sildenafil treatment
|
|
Sleep regulation
|
|
Small cell lung cancer
|
|
Small ligand GPCRs
|
|
SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome
|
|
Smith Magenis and Potocki Lupski syndrome copy number variation
|
|
Soluble ACE2 mediated cell entry of SARS CoV 2
|
|
Somatic sex determination
|
The determination of sex and sexual phenotypes in an organism's soma.
|
Somatroph axis GH and its relationship to dietary restriction and aging
|
|
Somitogenesis in the context of spondylocostal dysostosis
|
|
Sphingolipid metabolism in senescence
|
|
Sphingolipid metabolism integrated pathway
|
|
Sphingolipid metabolism overview
|
|
Sphingolipid pathway
|
|
Spina bifida
|
|
Spinal cord injury
|
|
Splicing factor NOVA regulated synaptic proteins
|
|
SREBF and miR33 in cholesterol and lipid homeostasis
|
|
SRF and miRs in smooth muscle differentiation and proliferation
|
|
Statin inhibition of cholesterol production
|
|
Steroid biosynthesis
|
|
Steroid hormone precursor biosynthesis
|
|
Sterol regulatory element binding proteins SREBP signaling
|
|
STING pathway in Kawasaki like disease and COVID 19
|
|
Striated muscle contraction pathway
|
|
Sudden infant death syndrome SIDS susceptibility pathways
|
|
Sulfatase and aromatase pathway
|
|
Sulfation biotransformation reaction
|
|
Sulindac metabolic pathway
|
|
Suppression of HMGB1 mediated inflammation by THBD
|
|
Synaptic signaling associated with autism spectrum disorder
|
|
Synaptic vesicle pathway
|
|
Synthesis of ceramides and 1 deoxyceramides
|
|
T cell activation SARS CoV 2
|
|
T cell antigen receptor TCR pathway during Staphylococcus aureus infection
|
|
T cell modulation in pancreatic cancer
|
|
T cell receptor and co stimulatory signaling
|
|
T cell receptor signaling
|
|
Tamoxifen metabolism
|
|
TAR syndrome
|
|
Target of rapamycin signaling
|
|
TCA cycle aka Krebs or citric acid cycle
|
|
TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc
|
|
TCA cycle in senescence
|
|
TCA cycle nutrient use and invasiveness of ovarian cancer
|
|
TGF beta receptor signaling
|
|
TGF beta receptor signaling in skeletal dysplasias
|
|
TGF beta signaling in thyroid cells for epithelial mesenchymal transition
|
|
TGF beta signaling pathway
|
|
TGFB Smad signaling
|
|
Tgif disruption of Shh signaling
|
|
Th17 cell differentiation pathway
|
|
Thermogenesis
|
|
Thiamine metabolic pathways
|
|
Thymic stromal lymphopoietin TSLP signaling
|
|
Thyroid hormones production and peripheral downstream signaling effects
|
|
Thyroid stimulating hormone TSH signaling
|
|
Thyroxine thyroid hormone production
|
|
TLR4 signaling and tolerance
|
|
TNF alpha signaling
|
|
TNF related weak inducer of apoptosis TWEAK signaling
|
|
Toll like receptor signaling
|
|
Toll like receptor signaling related to MyD88
|
|
TP53 network
|
|
Trans sulfuration one carbon metabolism and related pathways
|
|
Trans sulfuration pathway
|
|
Transcription co factors SKI and SKIL protein partners
|
|
Transcription factor regulation in adipogenesis
|
|
Transcription factors regulate miRNAs related to cardiac hypertrophy
|
|
Transcriptional activation by NRF2 in response to phytochemicals
|
|
Transcriptional cascade regulating adipogenesis
|
|
Translation factors
|
|
Translation inhibitors in chronically activated PDGFRA cells
|
|
Triacylglyceride synthesis
|
|
TROP2 regulatory signaling
|
|
Tryptophan catabolism leading to NAD production
|
|
Tryptophan metabolism
|
|
Tumor suppressor activity of SMARCB1
|
|
Type 2 papillary renal cell carcinoma
|
|
Type I collagen synthesis in the context of osteogenesis imperfecta
|
|
Type I interferon induction and signaling during SARS CoV 2 infection
|
|
Type II diabetes mellitus
|
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.|A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.
|
Type II interferon signaling
|
|
Type III interferon signaling
|
|
TYROBP causal network in microglia
|
|
Tyrosine metabolism and related disorders
|
|
UDP derived sugars synthesis in fibroblasts
|
|
Ulcerative colitis signaling
|
|
Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer
|
|
Unfolded protein response
|
|
Urea cycle and associated pathways
|
|
Urea cycle and metabolism of amino groups
|
|
Urea cycle and related diseases
|
|
Urotensin II mediated signaling
|
|
Valproic acid pathway
|
|
Vasopressin regulated water reabsorption
|
|
VEGFA VEGFR2 signaling
|
|
Vitamin A and carotenoid metabolism
|
|
Vitamin A1 and A5 X pathways
|
|
Vitamin B12 disorders
|
|
Vitamin B12 metabolism
|
|
Vitamin B6 dependent and responsive disorders
|
|
Vitamin D in inflammatory diseases
|
|
Vitamin D metabolism
|
|
Vitamin D receptor pathway
|
|
Vitamin D sensitive calcium signaling in depression
|
|
Vitamin K metabolism and activation of dependent proteins
|
|
Vitamins A and D action mechanisms
|
|
Warburg effect modulated by deubiquitinating enzymes and their substrates
|
|
White fat cell differentiation
|
The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole.
|
Wnt beta catenin signaling in leukemia
|
|
Wnt Beta catenin signaling inhibitors in current and past clinical trials
|
|
Wnt signaling
|
|
Wnt signaling and pluripotency
|
|
Wnt signaling in kidney disease
|
|
Zinc homeostasis
|
|