{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A1BG‐AS1 is a long noncoding RNA that has been demonstrated to play important roles in cancer progression. In hepatocellular carcinoma (HCC), A1BG‐AS1 is notably underexpressed, and low levels are associated with adverse clinical features such as microvascular invasion, high tumor grade, and advanced tumor stage, which ultimately translate into poor patient outcomes. Functional studies in HCC revealed that forced expression of A1BG‐AS1 suppressed cell proliferation, migration, and invasion, whereas its knockdown promoted these malignant behaviors. Mechanistically, A1BG‐AS1 acts as a competing endogenous RNA by sponging miR‐216a‐5p, thereby positively regulating the expression of tumor suppressors like phosphatase and tensin homolog (PTEN) and SMAD family member 7, which are inhibited by miR‐216a‐5p."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Broader transcriptomic analyses in HCC have underscored the significance of long noncoding RNAs and their involvement in complex ceRNA networks, reinforcing the role of such molecules in tumorigenesis and cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, investigations in breast cancer have identified A1BG‐AS1 as one of several immune‐related lncRNAs with prognostic value. In this context, A1BG‐AS1 was incorporated into a novel recurrence‐free survival nomogram, where together with other clinicopathological factors, it improved risk stratification compared to traditional staging systems, thus highlighting its potential utility as a biomarker across multiple cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, A1BG‐AS1 functions as a tumor suppressor in HCC by modulating key molecular pathways through a ceRNA mechanism and is emerging as a prognostic indicator in breast cancer. These findings suggest that A1BG‐AS1 may serve as both a diagnostic and therapeutic target in oncology.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jigang Bai, Bowen Yao, Liang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA A1BG-AS1 suppresses proliferation and invasion of hepatocellular carcinoma cells by targeting miR-216a-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28315"}], "href": "https://doi.org/10.1002/jcb.28315"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30556161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30556161"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jian Zhang, Dahua Fan, Zhixiang Jian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cancer Specific Long Noncoding RNAs Show Differential Expression Patterns and Competing Endogenous RNA Potential in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0141042"}], "href": "https://doi.org/10.1371/journal.pone.0141042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26492393"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26492393"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chengyun Li, Wenwen Zhang, Hanteng Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative analysis of dysregulated lncRNA-associated ceRNA network reveals potential lncRNA biomarkers for human hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.8758"}], "href": "https://doi.org/10.7717/peerj.8758"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32201648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32201648"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jianguo Lai, Bo Chen, Guochun Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular characterization of breast cancer: a potential novel immune-related lncRNAs signature."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-020-02578-4"}], "href": "https://doi.org/10.1186/s12967-020-02578-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33160384"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33160384"}]}]}]}