{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Apoptosis‐associated transcript in bladder cancer (AATBC) is an oncogenic long noncoding RNA that is overexpressed in several tumor types and contributes to cancer progression through multiple mechanisms. In nasopharyngeal carcinoma, for instance, elevated AATBC expression is associated with poor survival and enhanced migration, invasion, and metastasis by acting as a molecular sponge for miR‑1237‑3p, thereby upregulating the desmosome‐associated protein pinin (PNN) and subsequently promoting epithelial–mesenchymal transition via increased ZEB1 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In bladder cancer, AATBC overexpression correlates with higher tumor grade and stage; its inhibition results in G1 cell cycle arrest through modulation of cyclin D1 and CDK4, and induces apoptosis by activating the intrinsic pathway via phosphorylated JNK and suppressing NRF2 signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In breast cancer, AATBC has been shown to drive metastasis by activating the YAP1/Hippo signaling pathway through an AATBC–YBX1–MST1 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in prostate cancer, AATBC functions as a competing endogenous RNA by sponging miR‑1245b‑5p to upregulate the oncogene CASK, thereby promoting tumor growth both in vitro and in vivo."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Functional assays in melanoma further support an oncogenic role for AATBC in facilitating cell migration and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings underscore the multifaceted oncogenic functions of AATBC across different cancer types, suggesting its potential utility as both a prognostic biomarker and a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ting Tang, Liting Yang, Yujian Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12703"}], "href": "https://doi.org/10.1002/1878-0261.12703"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32364663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32364663"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fengjin Zhao, Tianxin Lin, Wang He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of a novel lincRNA AATBC suppresses proliferation and induces apoptosis in bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.2833"}], "href": "https://doi.org/10.18632/oncotarget.2833"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25473900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25473900"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Maonan Wang, Manli Dai, Dan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long noncoding RNA AATBC promotes breast cancer migration and invasion by interacting with YBX1 and activating the YAP1/Hippo signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2021.04.025"}], "href": "https://doi.org/10.1016/j.canlet.2021.04.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33951538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33951538"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wenyuan Zhang, Qionghong Liu, Jun Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA AATBC Promotes the Proliferation and Migration of Prostate Cancer Cell Through miR-1245b-5p/CASK Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S310529"}], "href": "https://doi.org/10.2147/CMAR.S310529"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34234553"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34234553"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kexin Yan, Yutao Wang, Yining Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene Instability-Related lncRNA Prognostic Model of Melanoma Patients via Machine Learning Strategy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/5582920"}], "href": "https://doi.org/10.1155/2021/5582920"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34122546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34122546"}]}]}]}