{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ABALON is a long non‐coding RNA that has emerged as a multifaceted regulator in cancer, particularly in lung malignancies. In lung cancer, ABALON functions as a competing endogenous RNA that sequesters microRNAs – notably miR-139-3p – thereby indirectly controlling the expression of downstream targets such as NOB1. Through this mechanism, ABALON contributes to tumorigenesis and has been proposed as a promising biological target for early diagnosis of lung cancer. In parallel, ABALON has been incorporated into immune-related prognostic signatures for lung adenocarcinoma and non–small cell lung cancer, where its dysregulation is associated with poorer patient survival and links to the modulation of tumor microenvironment and autophagy-related gene networks. Moreover, in the context of osteolysis following hip arthroplasty, a coexpression pair involving TAL1 and ABALON suggests that ABALON may also participate in the regulation of osteoclastogenesis. Collectively, these findings highlight the importance of ABALON in cancer biology and its potential utility both as a diagnostic biomarker and as a target for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xinhong Liu, Xin Zuo, Lijun Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated Analysis of the m6A-Related lncRNA Identified lncRNA ABALON/miR-139-3p/"}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "NOB1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Axis Was Involved in the Occurrence of Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S339032"}], "href": "https://doi.org/10.2147/CMAR.S339032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34849026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34849026"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Boxiang Zhang, Rui Wang, Kai Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An Immune-Related lncRNA Expression Profile to Improve Prognosis Prediction for Lung Adenocarcinoma: From Bioinformatics to Clinical Word."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.671341"}], "href": "https://doi.org/10.3389/fonc.2021.671341"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33968781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33968781"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Huihui Jiang, Aiqun Xu, Min Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Seven autophagy-related lncRNAs are associated with the tumor immune microenvironment in predicting survival risk of nonsmall cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brief Funct Genomics (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/bfgp/elab043"}], "href": "https://doi.org/10.1093/bfgp/elab043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34849558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34849558"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Guang Yang, Kai Tang, Li Qiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Critical Genes and lncRNAs in Osteolysis after Total Hip Arthroplasty and Osteoarthritis by RNA Sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/6681925"}], "href": "https://doi.org/10.1155/2021/6681925"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33791375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33791375"}]}]}]}