{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent integrative analyses of long non‑coding RNA (lncRNA) mediated competing endogenous RNA (ceRNA) networks in cancers have identified ABCA9‑AS1 as a putative regulator of tumorigenesis and patient survival."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In lung adenocarcinoma, ABCA9‑AS1 emerged as one of several lncRNAs within a prognostic signature wherein differential expression patterns were shown to significantly stratify overall survival. These findings suggest that ABCA9‑AS1, by acting as a ceRNA, likely sequesters certain microRNAs that would otherwise modulate the expression of critical mRNAs involved in tumorigenesis. Similarly, in head and neck squamous cell carcinoma, ceRNA network analyses have implicated ABCA9‑AS1 among other lncRNAs that impact patient outcomes, reinforcing its regulatory role in cancer biology. Together, these studies underscore the potential of ABCA9‑AS1 not only as a key modulator of gene expression through its ceRNA activity but also as a promising prognostic biomarker across distinct tumor types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaojuan Wang, Yawen Ding, Bangming Da, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of potential prognostic long non‑coding RNA signatures based on a competing endogenous RNA network in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2018.6719"}], "href": "https://doi.org/10.3892/or.2018.6719"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30272355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30272355"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiao-Nan Fang, Miao Yin, Hua Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of competitive endogenous RNAs network associated with head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-28957-y"}], "href": "https://doi.org/10.1038/s41598-018-28957-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30002503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30002503"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Haiyan Hu, Jie Zhang, Yinhui Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SPANXA2-OT1 Participates in the Occurrence and Development of EMT in Calcium Oxalate Crystal-Induced Kidney Injury by Adsorbing miR-204 and Up-Regulating Smad5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Med (Lausanne) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fmed.2021.719980"}], "href": "https://doi.org/10.3389/fmed.2021.719980"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34646842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34646842"}]}]}]}