{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although none of the provided abstracts mention ABHD15‐AS1 explicitly, the collective findings offer important context on how long noncoding RNAs (lncRNAs) modulate key pathological processes. In studies of human inflammatory responses, several lncRNAs were found to be rapidly regulated by endotoxemia in blood and adipose tissues, where they appear to integrate inflammatory signals with metabolic regulation (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, reviews of aging‐associated pathologies emphasize that lncRNAs are pivotal regulators of energy metabolism, immune function, and cellular senescence, thereby influencing conditions such as obesity, diabetes, and cardiovascular disease"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, aberrant lncRNA activity has been implicated in chronic inflammatory states as seen in sepsis and metabolic syndrome, suggesting that these transcripts contribute to untoward immune–metabolic cross talk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Finally, insights from atherosclerosis research corroborate the concept that lncRNAs play essential roles in vascular inflammation and lipid metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Within this broader framework, ABHD15‐AS1 likely functions as one of the many lncRNAs that respond to inflammatory triggers and metabolic disturbances. Its regulation, potentially paralleling other lincRNAs modulated by endotoxemia and metabolic stress, could influence the transcriptional and post‐transcriptional networks that govern immune activation, adipocyte function, and cellular senescence. In essence, ABHD15‐AS1 may serve as a molecular link that not only modulates inflammatory cascades in disease‐prone tissues but also contributes to the rewiring of gene expression programs underlying cardiometabolic and age‐related disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yichuan Liu, Jane F Ferguson, Chenyi Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tissue-specific RNA-Seq in human evoked inflammation identifies blood and adipose LincRNA signatures of cardiometabolic diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.113.303123"}], "href": "https://doi.org/10.1161/ATVBAHA.113.303123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24504737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24504737"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jiyoung Kim, Kyoung Mi Kim, Ji Heon Noh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNAs in diseases of aging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagrm.2015.06.013"}], "href": "https://doi.org/10.1016/j.bbagrm.2015.06.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26141605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26141605"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jieyu He, Chao Tu, Youshuo Liu "}, {"type": "b", "children": [{"type": "t", "text": "Role of lncRNAs in aging and age-related diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging Med (Milton) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/agm2.12030"}], "href": "https://doi.org/10.1002/agm2.12030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31942494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31942494"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chanan Meydan, Uriya Bekenstein, Hermona Soreq "}, {"type": "b", "children": [{"type": "t", "text": "Molecular Regulatory Pathways Link Sepsis With Metabolic Syndrome: Non-coding RNA Elements Underlying the Sepsis/Metabolic Cross-Talk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Mol Neurosci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fnmol.2018.00189"}], "href": "https://doi.org/10.3389/fnmol.2018.00189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29922126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29922126"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhengyi Zhang, David Salisbury, Tamer Sallam "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNAs in Atherosclerosis: JACC Review Topic of the Week."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Coll Cardiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jacc.2018.08.2161"}], "href": "https://doi.org/10.1016/j.jacc.2018.08.2161"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30384894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30384894"}]}]}]}