{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ABRAXAS2 (commonly referred to as ABRO1) functions as a critical scaffold protein that directs the assembly and compartmentalization of BRCC36‐containing deubiquitinase complexes. In the cytoplasm, ABRAXAS2 forms the BRISC complex, thereby conferring specificity for the removal of Lys63‐linked ubiquitin chains on a variety of substrates. Through its assembling role, ABRAXAS2 modulates key cellular processes such as inflammatory signaling – for instance, by promoting optimal NLRP3 inflammasome activation via deubiquitination events"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "– and regulates interferon receptor turnover by coordinating with metabolic enzymes like SHMT2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, ABRAXAS2 contributes to tumor suppression by stabilizing p53 through facilitating its interaction with USP7, and is implicated in protecting against replicative stress‐induced genome instability"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Its ability to assemble distinct BRCC36 complexes in the cytoplasm, as opposed to nuclear complexes formed via ABRAXAS, underscores its role in directing substrate selectivity and subcellular targeting"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Additional studies reveal that ABRAXAS2 can modulate deubiquitinase activity by competing with E3 ubiquitin ligases to stabilize other DUB components, such as BRCC3"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and by interacting with transcription factors including members of the AP‐1 family to promote cytoprotective responses under stress conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Collectively, these findings indicate that ABRAXAS2 is an essential regulatory adaptor that not only organizes deubiquitination at specific subcellular sites but also integrates diverse stress, inflammatory, and tumor‐suppressive signals to maintain cellular homeostasis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Guangming Ren, Xuanyi Zhang, Yang Xiao, et al. 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