ACOT7 Gene

HGNC Family	Acyl-CoA thioesterases (ACOT)
Name	acyl-CoA thioesterase 7
Description	This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Acyl‐CoA thioesterase 7 (ACOT7) is a multifunctional enzyme whose canonical role is to hydrolyze fatty acyl‐CoA esters into free fatty acids and coenzyme A, thereby modulating intracellular lipid fluxes. In macrophages, ACOT7 exhibits high activity toward arachidonoyl‐CoA and contributes to the regulation of eicosanoid metabolism, implicating it in inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In neurons, where ACOT7 is abundantly expressed, it serves to counterregulate fatty acid oxidation; its deficiency leads to an aberrant increase in long‐chain acyl‐CoA flux, metabolic stress, and ultimately neurodegeneration, highlighting its protective role in neural lipid homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n ACOT7 is also responsive to cellular genotoxic stress: exposure to agents such as ionizing radiation and doxorubicin induces ACOT7 in a time‐ and dose‐dependent manner, and its depletion activates the PKCζ–p53–p21 signaling cascade to enforce cell cycle arrest. Clinically, lower ACOT7 expression correlates with improved survival in breast and lung cancer patients, suggesting that its activity may promote chemotherapy resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In pancreatic β‐cells—where ACOT7 is normally “disallowed”—forced expression of mitochondrial ACOT7 disrupts glucose-stimulated insulin secretion by reducing ATP/ADP generation, membrane depolarization, and Ca²⁺ influx; this points to a potential role in β‐cell dysfunction associated with type 2 diabetes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In myeloid cells, ACOT7 is induced by lipopolysaccharide and contributes to the remodeling of glycerophospholipid species enriched in long-chain polyunsaturated acyl chains, although its deficiency here has limited effects on cytokine production."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, tissue-specific isoforms generated by alternative usage of first exons underscore its regulated expression in diverse organs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Aberrant overexpression of ACOT7 is associated with unfavorable outcomes in acute myeloid leukemia"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "and in gastric cancer, where its upregulation promotes malignant phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In the context of brain metastasis, elevated ACOT7, along with other lipid metabolic factors, appears to facilitate the metabolic adaptation necessary for tumor cell survival under nutrient stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n At the post‐transcriptional level, ACOT7 mRNA is directly regulated by RNA-binding proteins such as WIG1, which, together with Argonaute 2, modulate its stability and translation efficiency via microRNA-dependent and -independent pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Collectively, these findings position ACOT7 as a key integrator of lipid metabolism with cellular signaling pathways that impact inflammation, cell cycle regulation, and disease progression across multiple tissues.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jade K Forwood, Anil S Thakur, Gregor Guncar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0700974104"}], "href": "https://doi.org/10.1073/pnas.0700974104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17563367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17563367"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jessica M Ellis, G William Wong, Michael J Wolfgang "}, {"type": "b", "children": [{"type": "t", "text": "Acyl coenzyme A thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01548-12"}], "href": "https://doi.org/10.1128/MCB.01548-12"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23459938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23459938"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Seung Hee Jung, Hyung Chul Lee, Hyun Jung Hwang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKCζ-p53-p21 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2017.202"}], "href": "https://doi.org/10.1038/cddis.2017.202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28518146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28518146"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Aida Martinez-Sanchez, Timothy J Pullen, Pauline Chabosseau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db15-1240"}], "href": "https://doi.org/10.2337/db15-1240"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26861785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26861785"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Valerie Z Wall, Shelley Barnhart, Farah Kramer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (≥C20)-acyl chains in macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M076489"}], "href": "https://doi.org/10.1194/jlr.M076489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28416579"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28416579"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "M C Hunt, S Greene, K Hultenby, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative exon usage selectively determines both tissue distribution and subcellular localization of the acyl-CoA thioesterase 7 gene products."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-007-7062-6"}], "href": "https://doi.org/10.1007/s00018-007-7062-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17514357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17514357"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xinpei Zhang, Bo Liu, Jilei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression level of ACOT7 influences the prognosis in acute myeloid leukemia patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-182287"}], "href": "https://doi.org/10.3233/CBM-182287"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31640082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31640082"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Huiqin Feng, Xiaojian Liu "}, {"type": "b", "children": [{"type": "t", "text": "Interaction between ACOT7 and LncRNA NMRAL2P via Methylation Regulates Gastric Cancer Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Yonsei Med J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3349/ymj.2020.61.6.471"}], "href": "https://doi.org/10.3349/ymj.2020.61.6.471"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32469171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32469171"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Naiara Santana-Codina, Anna Marcé-Grau, Laia Muixí, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GRP94 Is Involved in the Lipid Phenotype of Brain Metastatic Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms20163883"}], "href": "https://doi.org/10.3390/ijms20163883"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31395819"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31395819"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hyung Chul Lee, Seung Hee Jung, Hyun Jung Hwang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WIG1 is crucial for AGO2-mediated ACOT7 mRNA silencing via miRNA-dependent and -independent mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkx307"}], "href": "https://doi.org/10.1093/nar/gkx307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28472401"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28472401"}]}]}]}
Synonyms	LACH, ACH1, BACH, HBACH, LACH1, CTE-II
Proteins	BACH_HUMAN
NCBI Gene ID	11332
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ACOT7 has 8,159 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for ACOT7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ACOT7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ACOT7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ACOT7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ACOT7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ACOT7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ACOT7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ACOT7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ACOT7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ACOT7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ACOT7 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ACOT7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ACOT7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ACOT7 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ACOT7 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ACOT7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ACOT7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ACOT7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ACOT7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ACOT7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ACOT7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ACOT7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ACOT7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ACOT7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ACOT7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ACOT7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ACOT7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ACOT7 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ACOT7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ACOT7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ACOT7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ACOT7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ACOT7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ACOT7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ACOT7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ACOT7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ACOT7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ACOT7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ACOT7 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ACOT7 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ACOT7 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ACOT7 from the GeneSigDB Published Gene Signatures dataset.