{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although ACVR2B‐AS1 was not implicated in prognostic signatures for liver, endometrial, or breast cancers (see"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ", two recent studies in thyroid malignancies have identified ACVR2B‐AS1 as a member of immune‐related long noncoding RNA panels with prognostic value. In thyroid cancer, including papillary thyroid cancer, ACVR2B‐AS1 is part of a multigene prognostic model that distinguishes high‐risk from low‐risk patients (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and its inclusion was further supported by Lasso regression analysis in an independent cohort of papillary thyroid cancer patients (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Although the precise mechanistic role of ACVR2B‐AS1 remains to be elucidated, its correlation with immune‐related gene expression and enrichment in signaling pathways such as PI3K‐Akt and focal adhesion suggests that it may be involved in modulating tumor microenvironment interactions and cancer progression. These findings collectively indicate that ACVR2B‐AS1 holds potential as a prognostic biomarker in thyroid cancer and warrants further functional investigation.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuanyuan Nie, Yan Jiao, Yanqing Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Identification of immune-related lncRNAs to improve the prognosis prediction for patients with papillary thyroid cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20204086"}], "href": "https://doi.org/10.1042/BSR20204086"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33554245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33554245"}]}]}]}