ADAM10 Gene

HGNC Family	Metzincin metallopeptidases, CD molecules (CD)
Name	ADAM metallopeptidase domain 10
Description	Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ADAM10 is a membrane‐anchored metalloprotease that functions as a central “sheddase” controlling the proteolytic release of the extracellular domains of a wide range of substrates. In several cell types, ADAM10 catalyzes the cleavage of membrane‐tethered precursors to release active growth factors such as epidermal growth factor receptor ligands, thereby promoting signal transduction pathways involved in proliferation and tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Equally important is its role in modulating cell–cell adhesion; ADAM10 cleaves adhesion molecules such as E‐cadherin and N‐cadherin. The shedding of E‐cadherin alters beta‐catenin localization and downstream gene expression, affecting migration and proliferation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", while proteolysis of N‐cadherin likewise regulates adhesive behavior and intracellular signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the nervous system, ADAM10 acts as the physiologically relevant constitutive α‐secretase for the amyloid precursor protein (APP), a function that precludes the amyloidogenic processing linked to Alzheimer’s disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " ADAM10 also processes other proteins that regulate cell–cell communication and signal transduction. For example, it mediates the shedding of ephrin-A ligands to modulate repulsive cell–cell interactions"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", and it cleaves CXCL16 to release its soluble form, thereby influencing inflammatory cell recruitment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, ligand-induced Notch receptor activation relies on ADAM10 to provide the critical ectodomain cleavage step necessary for subsequent γ-secretase–mediated release of the Notch intracellular domain."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n ADAM10 further exhibits context-dependent roles in disease. In host–pathogen interactions, it serves as a high-affinity receptor for Staphylococcus aureus α-hemolysin; binding of the toxin to ADAM10 triggers its relocalization into lipid rafts and initiates intracellular signaling that underlies cytotoxic pore formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Its proteolytic activity also contributes to the cleavage of neuroligin-3 in the tumor microenvironment, an event that has been implicated in the promotion of high-grade glioma growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In the vasculature, ADAM10-mediated shedding of VE-cadherin disrupts endothelial adherens junctions resulting in increased permeability and facilitating leukocyte transmigration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In addition, ADAM10 participates in the cleavage of receptors such as RAGE, thereby contributing to the modulation of inflammatory and stress responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, ADAM10 is a key regulator of ectodomain shedding that influences adhesion, signal transduction, cellular communication, and immunity. Its diverse substrate specificity and tightly controlled activity have significant implications in physiological processes and in pathological conditions ranging from cancer and neurodegeneration to infectious and inflammatory diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Umut Sahin, Gisela Weskamp, Kristine Kelly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200307137"}], "href": "https://doi.org/10.1083/jcb.200307137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14993236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14993236"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Thorsten Maretzky, Karina Reiss, Andreas Ludwig, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0500918102"}], "href": "https://doi.org/10.1073/pnas.0500918102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15958533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15958533"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Karina Reiss, Thorsten Maretzky, Andreas Ludwig, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7600548"}], "href": "https://doi.org/10.1038/sj.emboj.7600548"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15692570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15692570"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Peer-Hendrik Kuhn, Huanhuan Wang, Bastian Dislich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2010.167"}], "href": "https://doi.org/10.1038/emboj.2010.167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20676056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20676056"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Peter W Janes, Nayanendu Saha, William A Barton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2005.08.014"}], "href": "https://doi.org/10.1016/j.cell.2005.08.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16239146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16239146"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Soeren Abel, Christian Hundhausen, Rolf Mentlein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.172.10.6362"}], "href": "https://doi.org/10.4049/jimmunol.172.10.6362"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15128827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15128827"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Esra Cagavi Bozkulak, Gerry Weinmaster "}, {"type": "b", "children": [{"type": "t", "text": "Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00406-09"}], "href": "https://doi.org/10.1128/MCB.00406-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19704010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19704010"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Georgia A Wilke, Juliane Bubeck Wardenburg "}, {"type": "b", "children": [{"type": "t", "text": "Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1001815107"}], "href": "https://doi.org/10.1073/pnas.1001815107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20624979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20624979"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Humsa S Venkatesh, Lydia T Tam, Pamelyn J Woo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature24014"}], "href": "https://doi.org/10.1038/nature24014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28959975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28959975"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Beate Schulz, Jessica Pruessmeyer, Thorsten Maretzky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.107.169805"}], "href": "https://doi.org/10.1161/CIRCRESAHA.107.169805"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18420943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18420943"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ling Zhang, Monika Bukulin, Elzbieta Kojro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M806948200"}], "href": "https://doi.org/10.1074/jbc.M806948200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18952609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18952609"}]}]}]}
Synonyms	CDw156, AD10, HST18717, CD156C, KUZ, RAK, AD18, MADM
Proteins	ADA10_HUMAN
NCBI Gene ID	102
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ADAM10 has 13,103 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 139 datasets.

Click the + buttons to view associations for ADAM10 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ADAM10 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAM10 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAM10 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ADAM10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ADAM10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ADAM10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAM10 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving ADAM10 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAM10 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADAM10 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADAM10 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADAM10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAM10 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with ADAM10 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ADAM10 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ADAM10 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAM10 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ADAM10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ADAM10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with ADAM10 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with ADAM10 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ADAM10 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ADAM10 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ADAM10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ADAM10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ADAM10 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ADAM10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ADAM10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADAM10 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ADAM10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ADAM10 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ADAM10 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ADAM10 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ADAM10 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ADAM10 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving ADAM10 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving ADAM10 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ADAM10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ADAM10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ADAM10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ADAM10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.