ADAM11 Gene

HGNC Family	Metzincin metallopeptidases
Name	ADAM metallopeptidase domain 11
Description	This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ADAM11 is a non‐catalytic member of the ADAM family that is predominantly expressed in the central and peripheral nervous systems, where its structure predicts a key role as a cell adhesion molecule mediating integrin‐dependent cell–cell and cell–matrix interactions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In neural tissues, ADAM11 interacts with LGI family members and other partners to help orchestrate synaptic regulation and proper neuronal morphology. In particular, its involvement in the precise localization of ion channels at specialized synaptic sites—such as the clustering of Kv1 channels at cerebellar basket cell pinceaux—underscores its importance in modulating neuronal excitability."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": " Functional studies using ADAM11‐deficient mice further reveal that loss of ADAM11 impairs learning and motor coordination and alters pain responsiveness, suggesting that ADAM11 is critical for normal neural function and may influence inflammatory pain transmission."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In addition, neuroprotective interventions with agents such as melatonin and P7C3 have been shown to restore or upregulate neurodevelopmental protein expression that includes ADAM11, implying a role in endogenous neurogenesis and repair following injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Although its direct effects on cellular proliferation appear modest in glioma cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", clinical correlative studies have identified high ADAM11 expression as being associated with improved responses to tamoxifen therapy in breast cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and genomic investigations have even nominated ADAM11 as a candidate gene in developmental settings such as the regulation of pubertal timing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In summary, these findings collectively highlight the multifaceted role of ADAM11 in neural development, synaptic transmission, and the modulation of nervous system function—with potential implications for therapeutic targeting in neurological disorders and cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "–."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lei Wang, Jason A Hoggard, Erica D Korleski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiple non-catalytic ADAMs are novel integrin α4 ligands."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-017-3190-y"}], "href": "https://doi.org/10.1007/s11010-017-3190-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28913673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28913673"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "K Sagane, K Yamazaki, Y Mizui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (1999)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0378-1119(99)00253-x"}], "href": "https://doi.org/10.1016/s0378-1119(99"}, {"type": "t", "text": "00253-x) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "10433968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/10433968"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Katherine Owuor, Noam Y Harel, Dario J Englot, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2009.09.008"}], "href": "https://doi.org/10.1016/j.mcn.2009.09.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19796686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19796686"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Matthew J Kole, Jing Qian, Marc P Waase, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1346-15.2015"}], "href": "https://doi.org/10.1523/JNEUROSCI.1346-15.2015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26269648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26269648"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hung-En Hsia, Johanna Tüshaus, Tobias Brummer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functions of 'A disintegrin and metalloproteases (ADAMs)' in the mammalian nervous system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-019-03173-7"}], "href": "https://doi.org/10.1007/s00018-019-03173-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31236626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31236626"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Eiki Takahashi, Koji Sagane, Tohru Oki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficits in spatial learning and motor coordination in ADAM11-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Neurosci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2202-7-19"}], "href": "https://doi.org/10.1186/1471-2202-7-19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16504143"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16504143"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Eiki Takahashi, Koji Sagane, Takeshi Nagasu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered nociceptive response in ADAM11-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.brainres.2006.04.043"}], "href": "https://doi.org/10.1016/j.brainres.2006.04.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16729981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16729981"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Chang-Ming Chern, Jyh-Fei Liao, Yea-Hwey Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Melatonin ameliorates neural function by promoting endogenous neurogenesis through the MT2 melatonin receptor in ischemic-stroke mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2012.01.030"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2012.01.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22330064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22330064"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yea-Hwey Wang, Kuo-Tong Liou, Keng-Chang Tsai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GSK-3 inhibition through GLP-1R allosteric activation mediates the neurogenesis promoting effect of P7C3 after cerebral ischemic/reperfusional injury in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Toxicol Appl Pharmacol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.taap.2018.08.023"}], "href": "https://doi.org/10.1016/j.taap.2018.08.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30189238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30189238"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Giovanna M D'Abaco, Ken Ng, Lucy Paradiso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosurgery (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1227/01.neu.0000192363.84287.8b"}], "href": "https://doi.org/10.1227/01.neu.0000192363.84287.8b"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16385342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16385342"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Anieta M Sieuwerts, Marion E Meijer-van Gelder, Mieke Timmermans, et al. "}, {"type": "b", "children": [{"type": "t", "text": "How ADAM-9 and ADAM-11 differentially from estrogen receptor predict response to tamoxifen treatment in patients with recurrent breast cancer: a retrospective study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-05-0560"}], "href": "https://doi.org/10.1158/1078-0432.CCR-05-0560"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16243802"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16243802"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Nedenia Bonvino Stafuzza, Eliane Vianna da Costa E Silva, Rafael Medeiros de Oliveira Silva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study for age at puberty in young Nelore bulls."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Anim Breed Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jbg.12438"}], "href": "https://doi.org/10.1111/jbg.12438"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31515857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31515857"}]}]}]}
Synonyms	MDC
Proteins	ADA11_HUMAN
NCBI Gene ID	4185
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ADAM11 has 4,857 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 104 datasets.

Click the + buttons to view associations for ADAM11 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ADAM11 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAM11 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAM11 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ADAM11 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ADAM11 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ADAM11 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAM11 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAM11 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADAM11 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADAM11 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ADAM11 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADAM11 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAM11 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ADAM11 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAM11 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ADAM11 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ADAM11 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of ADAM11 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ADAM11 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ADAM11 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ADAM11 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ADAM11 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ADAM11 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ADAM11 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with ADAM11 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ADAM11 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ADAM11 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ADAM11 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ADAM11 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ADAM11 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ADAM11 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ADAM11 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAM11 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ADAM11 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ADAM11 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ADAM11 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with ADAM11 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAM11 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ADAM11 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of ADAM11 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of ADAM11 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.