ADAMTS1 Gene

HGNC Family	Metzincin metallopeptidases
Name	ADAM metallopeptidase with thrombospondin type 1 motif, 1
Description	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ADAMTS1 is a secreted metalloprotease that plays multifaceted roles by modulating the composition and function of the extracellular matrix in both normal physiology and disease. In the context of cancer, ADAMTS1 has been shown to contribute to bone metastasis by releasing EGF‐like growth factors that suppress osteoprotegerin in osteoblasts and promote osteoclastogenesis, thereby remodeling the bone microenvironment in favor of metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, its proteolytic activity is implicated in tumor progression; overexpression of ADAMTS1 in certain carcinoma models enhances tumor angiogenesis and invasion through the shedding of pro‐angiogenic ligands, whereas proteolytically inactive forms or its cleavage fragments can inhibit metastatic dissemination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In studies focused on angiogenesis, ADAMTS1 exerts anti‐angiogenic effects by directly binding to VEGF165 and thereby blocking VEGF receptor 2 (VEGFR2) phosphorylation, which suppresses endothelial cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In the developing heart, precise regulation of ADAMTS1 is essential; early repression by chromatin regulators permits the formation of a cardiac jelly suitable for trabeculation, while later induction of ADAMTS1 degrades this matrix, preventing excessive trabeculation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Within the ovary, ADAMTS1 is critical for normal folliculogenesis and ovulation. Its expression, regulated by luteinizing hormone and the progesterone receptor in granulosa cells, facilitates the proteolytic remodeling of the follicular extracellular matrix that is necessary for follicle wall neomorphogenesis and oocyte release"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Similarly, studies using ADAMTS1-null models have demonstrated impaired follicle development, reduced ovulation rates, and the trapping of mature oocytes within ovarian follicles."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the kidney, ADAMTS1 serves as a marker of pericyte activation in response to injury, where its increased expression is associated with destabilization of capillary networks and altered microvascular homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore the context-dependent functions of ADAMTS1 as both a modulator of angiogenesis and an executor of extracellular matrix remodeling, with significant implications for tumor progression, organ development, and reproductive physiology.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xin Lu, Qiongqing Wang, Guohong Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1824809"}], "href": "https://doi.org/10.1101/gad.1824809"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19608765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19608765"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Y-J Liu, Y Xu, Q Yu "}, {"type": "b", "children": [{"type": "t", "text": "Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1209287"}], "href": "https://doi.org/10.1038/sj.onc.1209287"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16314835"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16314835"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Alfonso Luque, Darren R Carpizo, M Luisa Iruela-Arispe "}, {"type": "b", "children": [{"type": "t", "text": "ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M212964200"}], "href": "https://doi.org/10.1074/jbc.M212964200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12716911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12716911"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kryn Stankunas, Calvin T Hang, Zhi-Yang Tsun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2007.11.018"}], "href": "https://doi.org/10.1016/j.devcel.2007.11.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18267097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18267097"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kari M H Doyle, Darryl L Russell, Venkataraman Sriraman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Coordinate transcription of the ADAMTS-1 gene by luteinizing hormone and progesterone receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2003-0380"}], "href": "https://doi.org/10.1210/me.2003-0380"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15256533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15256533"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "L Mittaz, D L Russell, T Wilson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adamts-1 is essential for the development and function of the urogenital system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.103.023911"}], "href": "https://doi.org/10.1095/biolreprod.103.023911"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14668204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14668204"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "M Shozu, N Minami, H Yokoyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAMTS-1 is involved in normal follicular development, ovulatory process and organization of the medullary vascular network in the ovary."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Endocrinol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1677/jme.1.01735"}], "href": "https://doi.org/10.1677/jme.1.01735"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16216914"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16216914"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hannah M Brown, Kylie R Dunning, Rebecca L Robker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirement for ADAMTS-1 in extracellular matrix remodeling during ovarian folliculogenesis and lymphangiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2006.10.012"}], "href": "https://doi.org/10.1016/j.ydbio.2006.10.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17097630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17097630"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Claudia Schrimpf, Cuiyan Xin, Gabriella Campanholle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2011080851"}], "href": "https://doi.org/10.1681/ASN.2011080851"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22383695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22383695"}]}]}]}
Synonyms	C3-C5, METH1
Proteins	ATS1_HUMAN
NCBI Gene ID	9510
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ADAMTS1 has 10,302 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 123 datasets.

Click the + buttons to view associations for ADAMTS1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ADAMTS1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by ADAMTS1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAMTS1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAMTS1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ADAMTS1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ADAMTS1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ADAMTS1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAMTS1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAMTS1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADAMTS1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADAMTS1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ADAMTS1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADAMTS1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAMTS1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ADAMTS1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ADAMTS1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAMTS1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ADAMTS1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ADAMTS1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ADAMTS1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ADAMTS1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ADAMTS1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ADAMTS1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ADAMTS1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ADAMTS1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ADAMTS1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADAMTS1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ADAMTS1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ADAMTS1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ADAMTS1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ADAMTS1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ADAMTS1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ADAMTS1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ADAMTS1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ADAMTS1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ADAMTS1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ADAMTS1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ADAMTS1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAMTS1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ADAMTS1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ADAMTS1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.