ADAMTS12 Gene

HGNC Family	Metzincin metallopeptidases
Name	ADAM metallopeptidase with thrombospondin type 1 motif, 12
Description	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The metalloproteinase ADAMTS12 is a multifunctional enzyme that plays versatile roles in extracellular matrix remodeling and cellular signaling across a range of physiological and pathological contexts. In articular tissues, ADAMTS12 interacts with cartilage oligomeric matrix protein (COMP) to mediate its proteolytic degradation, thereby contributing to cartilage degradation and the progression of arthritis and osteoarthritis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In skeletal tissues, its activity is closely linked to the regulation of chondrocyte differentiation and matrix production—with downstream effects on signaling pathways such as those involving parathyroid hormone-related protein and Indian hedgehog—that are important in normal chondrogenesis and disc homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": " In the context of cancer, ADAMTS12 exhibits tumor‐suppressive and antiangiogenic properties by attenuating pro‐tumorigenic signals, reducing cell proliferation, migration, and invasion, as evidenced in lung, colorectal, and gastric cancer models."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "10"}]}, {"type": "t", "text": " Furthermore, ADAMTS12 modulates trophoblast invasion via mechanisms involving integrin‐mediated cell–matrix adhesion, thereby contributing to proper placental development"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", while its altered expression in placental tissues has been associated with intrahepatic cholestasis of pregnancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In addition, ADAMTS12 participates in the regulation of inflammatory responses, as highlighted by its role in processing connective tissue growth factor (CTGF) in rheumatoid arthritis models"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", and emerging genetic evidence further implicates ADAMTS12 as a susceptibility factor in neuropsychiatric conditions such as schizophrenia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Collectively, these findings underscore the complexity and context‐dependent functions of ADAMTS12 in extracellular matrix turnover, inflammation, and cellular signaling—a diversity that highlights its potential as both a diagnostic biomarker and a therapeutic target in musculoskeletal, oncologic, inflammatory, and neuropsychiatric disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chuan-ju Liu, Wei Kong, Ke Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M513433200"}], "href": "https://doi.org/10.1074/jbc.M513433200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16611630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16611630"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chuan-Ju Liu "}, {"type": "b", "children": [{"type": "t", "text": "The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Clin Pract Rheumatol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncprheum0961"}], "href": "https://doi.org/10.1038/ncprheum0961"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19098927"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19098927"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "X H Bai, D W Wang, Y Luan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of chondrocyte differentiation by ADAMTS-12 metalloproteinase depends on its enzymatic activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-008-8633-x"}], "href": "https://doi.org/10.1007/s00018-008-8633-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19151918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19151918"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Quanbo Ji, Xiaojie Xu, Yameng Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-105/Runx2 axis mediates FGF2-induced ADAMTS expression in osteoarthritis cartilage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Med (Berl) (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00109-016-1380-9"}], "href": "https://doi.org/10.1007/s00109-016-1380-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26816250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26816250"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Qiang Zhang, Ming Huang, Xiaolin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Orthop Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jor.22069"}], "href": "https://doi.org/10.1002/jor.22069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22247065"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22247065"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "M El Hour, A Moncada-Pazos, S Blacher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2010.49"}], "href": "https://doi.org/10.1038/onc.2010.49"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20208563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20208563"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "María Llamazares, Alvaro J Obaya, Angela Moncada-Pazos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.005751"}], "href": "https://doi.org/10.1242/jcs.005751"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17895370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17895370"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Angela Moncada-Pazos, Alvaro J Obaya, Mario F Fraga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.050468"}], "href": "https://doi.org/10.1242/jcs.050468"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19638407"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19638407"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Da Wang, Tao Zhu, Fu-Biao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of ADAMTS12 in colorectal cancer-associated stroma prevents cancer development and is a good prognostic indicator of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-011-1723-x"}], "href": "https://doi.org/10.1007/s10620-011-1723-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21559743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21559743"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yangming Hou, Yingjuan Xu, Dequan Wu "}, {"type": "b", "children": [{"type": "t", "text": "ADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-90330-3"}], "href": "https://doi.org/10.1038/s41598-021-90330-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34040054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34040054"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Alexander G Beristain, Hua Zhu, Peter C K Leung "}, {"type": "b", "children": [{"type": "t", "text": "Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0018473"}], "href": "https://doi.org/10.1371/journal.pone.0018473"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21494557"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21494557"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Efser Oztas, Sibel Ozler, Ali O Ersoy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placental ADAMTS-12 Levels in the Pathogenesis of Preeclampsia and Intrahepatic Cholestasis of Pregnancy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1933719115604730"}], "href": "https://doi.org/10.1177/1933719115604730"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26363034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26363034"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jian-Lu Wei, Wenyu Fu, Aubryanna Hettinghouse, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheumatol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.40552"}], "href": "https://doi.org/10.1002/art.40552"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29750395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29750395"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Irina N Bespalova, Gary W Angelo, Ben P Ritter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variations in the ADAMTS12 gene are associated with schizophrenia in Puerto Rican patients of Spanish descent."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuromolecular Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12017-012-8169-y"}], "href": "https://doi.org/10.1007/s12017-012-8169-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22322903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22322903"}]}]}]}
Synonyms	PRO4389
Proteins	ATS12_HUMAN
NCBI Gene ID	81792
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ADAMTS12 has 5,806 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 114 datasets.

Click the + buttons to view associations for ADAMTS12 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ADAMTS12 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAMTS12 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ADAMTS12 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ADAMTS12 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ADAMTS12 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAMTS12 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAMTS12 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADAMTS12 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ADAMTS12 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADAMTS12 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAMTS12 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ADAMTS12 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAMTS12 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ADAMTS12 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ADAMTS12 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ADAMTS12 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ADAMTS12 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ADAMTS12 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ADAMTS12 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ADAMTS12 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ADAMTS12 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADAMTS12 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ADAMTS12 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with ADAMTS12 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ADAMTS12 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ADAMTS12 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ADAMTS12 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ADAMTS12 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ADAMTS12 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ADAMTS12 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ADAMTS12 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ADAMTS12 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ADAMTS12 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAMTS12 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ADAMTS12 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ADAMTS12 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ADAMTS12 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with ADAMTS12 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAMTS12 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ADAMTS12 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ADAMTS12 from the GeneSigDB Published Gene Signatures dataset.