ADAMTS13 Gene

HGNC Family	Metzincin metallopeptidases
Name	ADAM metallopeptidase with thrombospondin type 1 motif, 13
Description	This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ADAMTS13 is a circulating zinc‐dependent metalloprotease that plays a central role in vascular homeostasis by cleaving ultralarge von Willebrand factor (VWF) multimers, thereby preventing excessive platelet adhesion and microvascular thrombosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Under elevated shear stress, VWF undergoes a conformational change that exposes a cryptic cleavage site in its A2 domain, enabling ADAMTS13 to efficiently reduce VWF multimer size and activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Defects in ADAMTS13 activity—whether caused by genetic mutations or by autoantibodies—impair this proteolysis and lead to accumulation of highly prothrombotic VWF forms, which is the underlying mechanism in thrombotic thrombocytopenic purpura (TTP)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": " Furthermore, ADAMTS13 activity is modulated at the endothelial surface by factors such as fluid shear stress, interactions with VWF and platelet receptors, and even proteolytic inactivation by thrombin or plasmin, all of which contribute to the tight regulation of VWF-mediated platelet adhesion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": " In addition to its fundamental role in hemostasis, inadequate ADAMTS13 levels have been associated with enhanced inflammatory responses and an increased risk of thrombotic events in conditions such as sepsis, stroke, and myocardial injury."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": " Notably, circulating autoantibodies against ADAMTS13 can further compromise its function—sometimes without neutralizing enzymatic activity—thereby contributing to the pathogenesis of the acquired form of TTP."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Recent experimental findings demonstrating that recombinant ADAMTS13 can reduce thrombosis and infarct size in models of cerebral ischemia underscore its potential as a therapeutic agent."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Collectively, these studies highlight how ADAMTS13’s precise proteolytic trimming of VWF is vital for preventing abnormal platelet aggregation and maintaining vascular integrity, while its dysregulation can precipitate severe thrombotic and inflammatory disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "19"}]}, {"type": "t", "text": " Ongoing structural and mechanistic investigations are further elucidating the molecular interactions—including critical roles for the cysteine‐rich and spacer domains—that govern ADAMTS13 substrate recognition and activity, thereby informing improved diagnostic and therapeutic strategies in thrombotic microangiopathies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "G G Levy, W C Nichols, E C Lian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/35097008"}], "href": "https://doi.org/10.1038/35097008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11586351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11586351"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jing-fei Dong, Joel L Moake, Leticia Nolasco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2002-05-1401"}], "href": "https://doi.org/10.1182/blood-2002-05-1401"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12393397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12393397"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaohui Zhang, Kenneth Halvorsen, Cheng-Zhong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1170905"}], "href": "https://doi.org/10.1126/science.1170905"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19498171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19498171"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Koichi Kokame, Masanori Matsumoto, Kenji Soejima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.172277399"}], "href": "https://doi.org/10.1073/pnas.172277399"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12181489"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12181489"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tomoko Ono, Jun Mimuro, Seiji Madoiwa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2005-03-1087"}], "href": "https://doi.org/10.1182/blood-2005-03-1087"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16189276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16189276"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Valentina Bianchi, Rodolfo Robles, Lorenzo Alberio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Von Willebrand factor-cleaving protease (ADAMTS13) in thrombocytopenic disorders: a severely deficient activity is specific for thrombotic thrombocytopenic purpura."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2002-02-0344"}], "href": "https://doi.org/10.1182/blood-2002-02-0344"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12091372"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12091372"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "James T B Crawley, Rens de Groot, Yaozu Xiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-02-306597"}], "href": "https://doi.org/10.1182/blood-2011-02-306597"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21715306"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21715306"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "James T B Crawley, Jonathan K Lam, James B Rance, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteolytic inactivation of ADAMTS13 by thrombin and plasmin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-03-1101"}], "href": "https://doi.org/10.1182/blood-2004-03-1101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15388580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15388580"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Masashi Akiyama, Soichi Takeda, Koichi Kokame, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0909755106"}], "href": "https://doi.org/10.1073/pnas.0909755106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19880749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19880749"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Bing-Qiao Zhao, Anil K Chauhan, Matthias Canault, et al. "}, {"type": "b", "children": [{"type": "t", "text": "von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2009-03-213264"}], "href": "https://doi.org/10.1182/blood-2009-03-213264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19687510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19687510"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Alexander S Savchenko, Julian I Borissoff, Kimberly Martinod, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2013-07-514992"}], "href": "https://doi.org/10.1182/blood-2013-07-514992"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24200682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24200682"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Clemens L Bockmeyer, Ralf A Claus, Ulrich Budde, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inflammation-associated ADAMTS13 deficiency promotes formation of ultra-large von Willebrand factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.11677"}], "href": "https://doi.org/10.3324/haematol.11677"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18166799"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18166799"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Manfred Rieger, Pier Mannuccio Mannucci, Johanna A Kremer Hovinga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAMTS13 autoantibodies in patients with thrombotic microangiopathies and other immunomediated diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-11-4490"}], "href": "https://doi.org/10.1182/blood-2004-11-4490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15890682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15890682"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Frederik Denorme, Friederike Langhauser, Linda Desender, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2015-08-662650"}], "href": "https://doi.org/10.1182/blood-2015-08-662650"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26929275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26929275"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Flora Peyvandi, Silvia Lavoretano, Roberta Palla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAMTS13 and anti-ADAMTS13 antibodies as markers for recurrence of acquired thrombotic thrombocytopenic purpura during remission."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.11739"}], "href": "https://doi.org/10.3324/haematol.11739"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18223285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18223285"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Barbara Plaimauer, Klaus Zimmermann, Dirk Völkel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cloning, expression, and functional characterization of the von Willebrand factor-cleaving protease (ADAMTS13)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2002-05-1397"}], "href": "https://doi.org/10.1182/blood-2002-05-1397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12393399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12393399"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Anil K Chauhan, Janka Kisucka, Alexander Brill, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAMTS13: a new link between thrombosis and inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20080130"}], "href": "https://doi.org/10.1084/jem.20080130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18695007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18695007"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Arnoldo Padilla, Joel L Moake, Aubrey Bernardo, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2003-08-2861"}], "href": "https://doi.org/10.1182/blood-2003-08-2861"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14512308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14512308"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Kenji Nishio, Patricia J Anderson, X Long Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0402041101"}], "href": "https://doi.org/10.1073/pnas.0402041101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15249683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15249683"}]}]}]}
Synonyms	C9ORF8, ADAM-TS13, ADAMTS-13, VWFCP, VWF-CP
Proteins	ATS13_HUMAN
NCBI Gene ID	11093
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ADAMTS13 has 6,928 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 118 datasets.

Click the + buttons to view associations for ADAMTS13 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ADAMTS13 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by ADAMTS13 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAMTS13 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAMTS13 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ADAMTS13 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ADAMTS13 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ADAMTS13 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAMTS13 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAMTS13 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADAMTS13 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADAMTS13 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ADAMTS13 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADAMTS13 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAMTS13 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ADAMTS13 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAMTS13 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ADAMTS13 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ADAMTS13 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with ADAMTS13 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with ADAMTS13 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of ADAMTS13 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ADAMTS13 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ADAMTS13 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ADAMTS13 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ADAMTS13 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ADAMTS13 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ADAMTS13 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ADAMTS13 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ADAMTS13 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ADAMTS13 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ADAMTS13 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for ADAMTS13 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving ADAMTS13 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving ADAMTS13 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ADAMTS13 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ADAMTS13 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ADAMTS13 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ADAMTS13 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ADAMTS13 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ADAMTS13 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAMTS13 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.