{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ADAMTS9‐AS1 is a long non‐coding RNA whose functions appear to be highly context‐dependent across a range of human cancers and other diseases. In colorectal cancer, for example, one set of studies shows that ADAMTS9‐AS1 is downregulated and acts as a tumor suppressor by inhibiting cell proliferation, migration, and the Wnt/β‐catenin signaling pathway, while other reports indicate that its upregulation correlates with advanced disease and worse prognosis, suggesting opposing roles in tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In bladder cancer and hepatocellular carcinoma, elevated ADAMTS9‐AS1 levels have been associated with enhanced cell proliferation, migration, and invasion through activation of the PI3K/AKT/mTOR cascade; conversely, in prostate and breast cancers, reduced expression contributes to tumor progression by promoting cell growth and impairing apoptosis via mechanisms that involve its function as a competing endogenous RNA (ceRNA) regulating targets such as cyclin D1 and ZFP36 through microRNA sponging."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": " In ovarian cancer and endometriosis, ADAMTS9‐AS1 has been implicated in the modulation of ferroptosis and autophagy by sponging specific microRNAs (such as miR‐587 and miR‐6516‐5p), thereby affecting the expression of key regulators like SLC7A11 and GPX4, which in turn influences cell survival and migratory behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In glioma and non‐small cell lung cancer the overexpression of ADAMTS9‐AS1 has been linked with oncogenic activities—including alterations in Wnt signaling and cell cycle progression—further underscoring its multifaceted role in various tumor types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Collectively, ADAMTS9‐AS1 is frequently embedded within ceRNA networks that influence critical pathways regulating proliferation, apoptosis, migration, autophagy, and ferroptosis, and its expression levels have been correlated with clinicopathological features and patient survival outcomes. These findings support its promise as a potential diagnostic biomarker and therapeutic target across multiple cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ning Li, Juan Li, Qi Mi, et al. 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