{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ADARB2‐AS1 is a long non‐coding RNA that has emerged as a potential biomarker and regulator in multiple cancer contexts. In HER‐2–enriched breast cancer, ADARB2‐AS1 was identified as one of the core lncRNAs in a coexpression network, suggesting it may play a role in the complex regulatory processes that underlie the aggressive phenotype of this subtype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In pancreatic ductal adenocarcinoma, ADARB2‐AS1 contributed to an eight‐lncRNA signature that distinguished aggressive, malignant intraductal papillary mucinous neoplasms from indolent lesions, highlighting its potential utility in noninvasive diagnostic panels."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in endometrial carcinoma, ADARB2‐AS1 was incorporated into a prognostic signature alongside other lncRNAs, where its expression helped stratify patients by recurrence risk, thus providing prognostic information independent of traditional clinical factors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Collectively, these findings indicate that ADARB2‐AS1 may function as a key component in ceRNA and coexpression networks that modulate cancer progression and offer promise as both a diagnostic and prognostic biomarker in diverse tumor types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fan Yang, Shixu Lyu, Siyang Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression profile analysis of long noncoding RNA in HER-2-enriched subtype breast cancer by next-generation sequencing and bioinformatics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S97664"}], "href": "https://doi.org/10.2147/OTT.S97664"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26929647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26929647"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jennifer B Permuth, Dung-Tsa Chen, Sean J Yoder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Linc-ing Circulating Long Non-coding RNAs to the Diagnosis and Malignant Prediction of Intraductal Papillary Mucinous Neoplasms of the Pancreas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-09754-5"}], "href": "https://doi.org/10.1038/s41598-017-09754-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28874676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28874676"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Leilei Xia, Ye Wang, Qi Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated Bioinformatic Analysis of a Competing Endogenous RNA Network Reveals a Prognostic Signature in Endometrial Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2019.00448"}], "href": "https://doi.org/10.3389/fonc.2019.00448"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31192139"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31192139"}]}]}]}