ADCY2 Gene

HGNC Family	Adenylate cyclases (ADCY)
Name	adenylate cyclase 2 (brain)
Description	This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Adenylyl cyclase 2 (ADCY2) is a membrane‐associated enzyme that catalyzes the conversion of ATP to cyclic AMP (cAMP) in response to receptor stimulation, and its activity plays a central role in organizing localized cAMP signaling events that regulate diverse physiological processes. Several genetic studies have implicated ADCY2 in human disease. Polymorphisms in ADCY2 have been associated with lung function and severe chronic obstructive pulmonary disease, suggesting a contribution of ADCY2‐mediated cAMP production to airway physiology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In neuropsychiatric research, ADCY2 emerges as a candidate gene for bipolar disorder and related mood disorders, implicating altered ADCY2 function in dysfunctional CREB/ cAMP signaling and neural plasticity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In studies of G-protein–coupled receptor (GPCR) signaling, ADCY2 has been shown to participate in preassembled signalosomes; for example, upon activation of Gq-coupled muscarinic receptors, AKAP79 recruits protein kinase C to activate ADCY2, thereby producing localized cAMP pools that modulate downstream effectors such as interleukin-6 expression in bronchial smooth muscle cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, the modulation of ADCY2 activity is subject to regulation by interacting proteins; Dexras1, for instance, can impede protein kinase C–mediated stimulation of ADCY2, revealing a layer of control over receptor-coupled cAMP accumulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In the oncology arena, an ADCY2 variant (rs4702484) has been linked to differences in progression-free survival in colorectal cancer patients treated with capecitabine, highlighting potential pharmacogenetic implications of ADCY2 variation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Finally, genome-wide analyses have identified a novel locus near ADCY2 that may serve as an additional regulator of plasma factor VII-activating protease activity, thereby extending the impact of ADCY2-linked signaling to vascular remodeling and inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Megan Hardin, Jan Zielinski, Emily S Wan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2012-0011OC"}], "href": "https://doi.org/10.1165/rcmb.2012-0011OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22461431"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22461431"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei Xu, Sarah Cohen-Woods, Qian Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2350-15-2"}], "href": "https://doi.org/10.1186/1471-2350-15-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24387768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24387768"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Cheng-Bing Huang, Wen-Jie Shi, Cong-Jie Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of adenylate cyclase-2 gene polymorphism with bipolar disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian J Psychiatr (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajp.2020.102150"}], "href": "https://doi.org/10.1016/j.ajp.2020.102150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32447269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32447269"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jia X Shen, Dermot M F Cooper "}, {"type": "b", "children": [{"type": "t", "text": "AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20130359"}], "href": "https://doi.org/10.1042/BJ20130359"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23889134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23889134"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Amy S Bogard, Anna V Birg, Rennolds S Ostrom "}, {"type": "b", "children": [{"type": "t", "text": "Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Naunyn Schmiedebergs Arch Pharmacol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00210-013-0950-4"}], "href": "https://doi.org/10.1007/s00210-013-0950-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24363043"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24363043"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Chau H Nguyen, Val J Watts "}, {"type": "b", "children": [{"type": "t", "text": "Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.105.019133"}], "href": "https://doi.org/10.1124/mol.105.019133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16489124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16489124"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lieke H van Huis-Tanja, Ewoud Ewing, R J H M van der Straaten, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical validation study of genetic markers for capecitabine efficacy in metastatic colorectal cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenet Genomics (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/FPC.0000000000000119"}], "href": "https://doi.org/10.1097/FPC.0000000000000119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25815774"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25815774"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "M Olsson, T M Stanne, A Pedersen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide analysis of genetic determinants of circulating factor VII-activating protease (FSAP) activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Thromb Haemost (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jth.14258"}], "href": "https://doi.org/10.1111/jth.14258"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30070759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30070759"}]}]}]}
Synonyms	HBAC2, AC2
Proteins	ADCY2_HUMAN
NCBI Gene ID	108
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ADCY2 has 6,164 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 127 datasets.

Click the + buttons to view associations for ADCY2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ADCY2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by ADCY2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADCY2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADCY2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ADCY2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ADCY2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ADCY2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADCY2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ADCY2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADCY2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADCY2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ADCY2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADCY2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ADCY2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ADCY2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADCY2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ADCY2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ADCY2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ADCY2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ADCY2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ADCY2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ADCY2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ADCY2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADCY2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ADCY2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ADCY2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ADCY2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ADCY2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ADCY2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ADCY2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ADCY2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ADCY2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ADCY2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ADCY2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ADCY2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for ADCY2 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ADCY2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADCY2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ADCY2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ADCY2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ADCY2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.