{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a recent genome‐wide association study of adiponectin levels (1), multiple independent genetic signals were identified at the ADIPOQ locus that influence transcriptional regulation in adipose tissue. Among the seven distinct association signals at this locus, one signal was specifically linked to decreased expression of ADIPOQ‐AS1. Notably, alleles that increase adiponectin levels were associated with reduced ADIPOQ‐AS1 expression, contrasting with the parallel increase observed for ADIPOQ and LINC02043 at a different signal. These findings suggest that ADIPOQ‐AS1, an antisense transcript at the ADIPOQ locus, may play a regulatory role in adiponectin biology, potentially acting as a modulator of gene expression in adipose tissue. The study further highlights that a complex array of molecular mechanisms—including missense, splice, promoter, and enhancer variants—contribute to the regulation of multiple transcripts within this locus."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cassandra N Spracklen, Apoorva K Iyengar, Swarooparani Vadlamudi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1009019"}], "href": "https://doi.org/10.1371/journal.pgen.1009019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32915782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32915782"}]}]}]}