{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Adipogenesis regulatory factor-antisense RNA 1 (ADIRF-AS1) has emerged as a multifunctional long noncoding RNA with context‐dependent roles in several pathological conditions. In osteosarcoma, ADIRF-AS1 is markedly overexpressed and its elevated level correlates with a poorer overall survival. Functional studies demonstrated that ADIRF-AS1 promotes cell proliferation, migration, and invasion while simultaneously suppressing apoptosis, thereby contributing to tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In intervertebral disc degeneration (IDD), contrasting expression dynamics were observed. Here, ADIRF-AS1 is downregulated in severely degenerated nucleus pulposus tissues, and its overexpression mitigates degenerative changes. Mechanistically, ADIRF-AS1 acts as a competing endogenous RNA by sponging miR-214-3p, which in turn relieves the repression of SERPINA1—a molecule that enhances cell viability and dampens apoptosis and senescence."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of intrauterine adhesion, ADIRF-AS1 is identified among several key lncRNAs within a complex ceRNA network implicated in the disease’s development. Although its exact mechanistic contributions remain to be fully elucidated here, its differential expression suggests a role in modulating pathways such as ion transmembrane transport and cGMP-PKG signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In colorectal cancer, ADIRF-AS1 is incorporated into a metabolic lncRNA signature wherein its expression level contributes to the risk score that differentiates patient outcomes. Its inclusion in this prognostic model indicates that, beyond its roles in other diseases, ADIRF-AS1 may also influence tumor metabolism and affect immune cell-related functions, thereby impacting tumorigenesis and disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although a separate investigation into ceRNA networks during keloid formation did not specifically focus on ADIRF-AS1, the overall emphasis on lncRNA-mediated regulatory mechanisms in fibrotic conditions reinforces the emerging notion that lncRNAs such as ADIRF-AS1 may have wide-ranging functions in diverse pathological contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lingling Xu, Yinling Tan, Fengxia Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA ADIRF antisense RNA 1 upregulates insulin receptor substrate 1 to decrease the aggressiveness of osteosarcoma by sponging microRNA-761."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2019872"}], "href": "https://doi.org/10.1080/21655979.2021.2019872"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35030964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35030964"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hua Zhong, Zhihong Zhou, Lebin Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1/miR-214-3p axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.trsl.2022.02.006"}], "href": "https://doi.org/10.1016/j.trsl.2022.02.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35196590"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35196590"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jingni Zhang, Peng Jiang, Yuan Tu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and validation of long non-coding RNA associated ceRNAs in intrauterine adhesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2017578"}], "href": "https://doi.org/10.1080/21655979.2021.2017578"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34968168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34968168"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yongqu Lu, Wendong Wang, Zhenzhen Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA profile study identifies a metabolism-related signature for colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s10020-021-00343-x"}], "href": "https://doi.org/10.1186/s10020-021-00343-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34344319"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34344319"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yu Deng, Yangbin Xu, Shuqia Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Secondary data mining of GEO database for long non-coding RNA and Competing endogenous RNA network in keloid-prone individuals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.104054"}], "href": "https://doi.org/10.18632/aging.104054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33203788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33203788"}]}]}]}