{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a recent investigation of esophageal squamous cell carcinoma (ESCC) using TCGA sequencing data, the long non‐coding RNA ADNP‐AS1 was identified as one of the top tumor grade‐related lncRNAs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although its precise molecular function remains to be fully defined, the significant association between ADNP‐AS1 expression levels and tumor grade suggests that this lncRNA may play an important regulatory role in the progression and pathological grading of ESCC. The study’s integrated approach—including differential expression analyses, correlation with tumor grades, and network-based assessments—indicates that changes in ADNP‐AS1 expression could contribute to the molecular mechanisms underlying this cancer, thereby highlighting its potential utility as a biomarker or a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xin Gao, Qian Liu, Xue Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Screening of tumor grade-related mRNAs and lncRNAs for Esophagus Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23797"}], "href": "https://doi.org/10.1002/jcla.23797"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33960436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33960436"}]}]}]}