ADORA2A Gene

HGNC Family	G protein-coupled receptors
Name	adenosine A2a receptor
Description	This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "The adenosine A<sub>2A</sub> receptor (ADORA2A) is a G protein–coupled receptor that plays multifaceted roles in regulating immune responses, neural function, and tissue protection. In the immune system, adenosine produced by the concerted action of the ectoenzymes CD39 and CD73 establishes immunosuppressive loops by engaging A<sub>2A</sub> receptors on activated T effector cells. This signaling pathway is critical for the suppressive activity of regulatory T cells and helps protect normal tissues from inflammatory damage, yet in the tumor microenvironment it can inhibit antitumor lymphocyte function, thereby promoting tumor survival. In support of these contrasting roles, genetic deletion or pharmacological blockade of A<sub>2A</sub> receptors enhances antitumor T‐cell and natural killer (NK) cell responses, whereas intact A<sub>2A</sub> receptor signaling is associated with suppression of cytotoxic immune responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "Structural studies have provided high‐resolution insights into the ligand–receptor interactions, conformational dynamics upon agonist binding, and the interfaces involved in G protein coupling. These details not only deepen our understanding of receptor activation but also inform the rational design of selective ligands and allosteric modulators."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "In the central nervous system, A<sub>2A</sub> receptor activation has been shown to mediate synaptotoxic processes induced by beta‐amyloid, leading to memory dysfunction; thus, receptor blockade offers neuroprotective benefits. Moreover, within the nucleus accumbens the A<sub>2A</sub> receptor is a key mediator of the wake‐promoting effects of caffeine, linking it to arousal mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "Additional roles for A<sub>2A</sub> receptor signaling have been identified in tissue protection. For instance, activation of A<sub>2A</sub> receptors on CD4<sup>+</sup> T cells limits their accumulation in reperfused myocardium, thereby reducing ischemia/reperfusion injury, and receptor signaling on bone marrow–derived cells contributes to the suppression of renal inflammatory responses during ischemia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Furthermore, A<sub>2A</sub> receptor engagement can dampen proinflammatory cytokine production in models of colitis and modulate N-methyl-D-aspartate receptor–mediated calcium signaling in the striatum, underscoring its diverse roles in regulating inflammation and neurotransmission."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "Collectively, these studies highlight ADORA2A as a central checkpoint in immune homeostasis, neuroprotection, and tissue preservation. Its strategic localization on immune cells, neurons, and vascular as well as parenchymal tissues makes the A<sub>2A</sub> receptor an attractive target for therapeutic intervention in cancer, cardiovascular disease, neurodegeneration, and inflammatory disorders."}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Silvia Deaglio, Karen M Dwyer, Wenda Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20062512"}], "href": "https://doi.org/10.1084/jem.20062512"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17502665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17502665"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Akio Ohta, Elieser Gorelik, Simon J Prasad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A2A adenosine receptor protects tumors from antitumor T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0605251103"}], "href": "https://doi.org/10.1073/pnas.0605251103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16916931"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16916931"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Arabella Young, Shin Foong Ngiow, Yulong Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A2AR Adenosine Signaling Suppresses Natural Killer Cell Maturation in the Tumor Microenvironment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-17-2826"}], "href": "https://doi.org/10.1158/0008-5472.CAN-17-2826"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29229601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29229601"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Caglar Cekic, Yuan-Ji Day, Duygu Sag, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-13-3583"}], "href": "https://doi.org/10.1158/0008-5472.CAN-13-3583"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25377469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25377469"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Wei Liu, Eugene Chun, Aaron A Thompson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for allosteric regulation of GPCRs by sodium ions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1219218"}], "href": "https://doi.org/10.1126/science.1219218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22798613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22798613"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Guillaume Lebon, Tony Warne, Patricia C Edwards, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature10136"}], "href": "https://doi.org/10.1038/nature10136"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21593763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21593763"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Andrew S Doré, Nathan Robertson, James C Errey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2011.06.014"}], "href": "https://doi.org/10.1016/j.str.2011.06.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21885291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21885291"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Byron Carpenter, Rony Nehmé, Tony Warne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of the adenosine A(2A) receptor bound to an engineered G protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature18966"}], "href": "https://doi.org/10.1038/nature18966"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27462812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27462812"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Paula M Canas, Lisiane O Porciúncula, Geanne M A Cunha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.3728-09.2009"}], "href": "https://doi.org/10.1523/JNEUROSCI.3728-09.2009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19940169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19940169"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Michael Lazarus, Hai-Ying Shen, Yoan Cherasse, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.6730-10.2011"}], "href": "https://doi.org/10.1523/JNEUROSCI.6730-10.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21734299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21734299"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Zequan Yang, Yuan-Ji Day, Marie-Claire Toufektsian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.106.649244"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.106.649244"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17060376"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17060376"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yuan-Ji Day, Liping Huang, Marcia J McDuffie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI15483"}], "href": "https://doi.org/10.1172/JCI15483"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12975473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12975473"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Makoto Naganuma, Elizabeth B Wiznerowicz, Courtney M Lappas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cutting edge: Critical role for A2A adenosine receptors in the T cell-mediated regulation of colitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.177.5.2765"}], "href": "https://doi.org/10.4049/jimmunol.177.5.2765"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16920910"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16920910"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Michael J Higley, Bernardo L Sabatini "}, {"type": "b", "children": [{"type": "t", "text": "Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nn.2592"}], "href": "https://doi.org/10.1038/nn.2592"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20601948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20601948"}]}]}]}
Synonyms	A2AR, RDC8
Proteins	AA2AR_HUMAN
NCBI Gene ID	135
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ADORA2A has 8,034 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for ADORA2A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ADORA2A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADORA2A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADORA2A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ADORA2A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ADORA2A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ADORA2A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADORA2A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADORA2A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ADORA2A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADORA2A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ADORA2A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ADORA2A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADORA2A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ADORA2A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ADORA2A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of ADORA2A gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ADORA2A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ADORA2A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ADORA2A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ADORA2A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADORA2A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ADORA2A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ADORA2A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ADORA2A gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ADORA2A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for ADORA2A protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ADORA2A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ADORA2A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ADORA2A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ADORA2A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ADORA2A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for ADORA2A protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ADORA2A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADORA2A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ADORA2A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ADORA2A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ADORA2A gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with ADORA2A gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ADORA2A gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ADORA2A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ADORA2A from the GeneSigDB Published Gene Signatures dataset.