{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Adenylosuccinate synthase 2 (ADSS2) is an enzyme that plays a critical role in purine nucleotide metabolism by catalyzing the first committed step in adenosine monophosphate (AMP) synthesis. In this reaction, ADSS2 converts inosine monophosphate (IMP) into adenylosuccinate, thereby funneling IMP into the biosynthetic pathway for AMP. This step is essential for maintaining adequate cellular pools of AMP, which in turn supports energy homeostasis, nucleic acid synthesis, and overall cell proliferation.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Alterations in ADSS2 activity have been implicated in several pathological conditions. For example, reduced messenger RNA levels of ADSS have been observed in patients with schizophrenia, suggesting that changes in ADSS2 expression or function might contribute to neuropsychiatric disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, the enzyme is a component of the purine salvage pathway in certain pathogens such as "}, {"type": "i", "children": [{"type": "t", "text": "Helicobacter pylori"}]}, {"type": "t", "text": ", where its inhibition is being explored as a potential therapeutic strategy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, reviews of inborn errors of purine metabolism highlight that deficiencies in enzymes like ADSS2 lead to a broad clinical spectrum that may include neurological impairments, muscle weakness, and other metabolic disturbances, underscoring its fundamental role in normal cellular physiology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, ADSS2 functions as a key regulatory enzyme in the purine nucleotide cycle by catalyzing the conversion of IMP to adenylosuccinate, a critical step that commits purine metabolites to AMP synthesis. Its proper activity is vital for energy metabolism and nucleic acid synthesis, and disruptions in its function are associated with varied pathological states, making it a potential target for therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fuquan Zhang, Yong Xu, Pozi Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2350-9-119"}], "href": "https://doi.org/10.1186/1471-2350-9-119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19115993"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19115993"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fuquan Zhang, Pak C Sham, Hua Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An association study of ADSS gene polymorphisms with schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Behav Brain Funct (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1744-9081-4-39"}], "href": "https://doi.org/10.1186/1744-9081-4-39"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18721483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18721483"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marta Ilona Wojtyś, Radosław Jaźwiec, Saša Kazazić, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A comprehensive method for determining cellular uptake of purine nucleoside phosphorylase and adenylosuccinate synthetase inhibitors by H. pylori."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Appl Microbiol Biotechnol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00253-021-11510-9"}], "href": "https://doi.org/10.1007/s00253-021-11510-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34562116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34562116"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Joseph P Dewulf, Sandrine Marie, Marie-Cécile Nassogne "}, {"type": "b", "children": [{"type": "t", "text": "Disorders of purine biosynthesis metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2021.12.016"}], "href": "https://doi.org/10.1016/j.ymgme.2021.12.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34998670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34998670"}]}]}]}