{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n AGPAT4-IT1 is an immune‐related long non‐coding RNA that was incorporated into a prognostic signature for neuroblastoma, demonstrating its potential utility as a biomarker. In the study, AGPAT4-IT1 was one of eleven immune-related lncRNAs combined in the RS_Lnc signature, which, along with a five-gene signature (RS5_G), was used to stratify patients into high- and low-risk groups based on overall and event/progression-free survival outcomes. The findings indicate that higher risk scores—attributed in part to the expression patterns of AGPAT4-IT1 and its companion lncRNAs—correlate with a decrease in activated dendritic cells and CD8+ T cells and an increase in Th2 cells, suggesting an immune microenvironment less favorable for tumor control. Moreover, functional enrichment analyses revealed that these immune-related lncRNAs are predominantly involved in pathways related to both cancer progression and immune regulation. These insights position AGPAT4-IT1 as a promising candidate in the realm of prognostic biomarkers for neuroblastoma, with further experimental and clinical validation needed to fully elucidate its precise biological function and mechanism of action in cancer-associated immune responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaodan Zhong, Ying Tao, Jian Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic Signature of Immune Genes and Immune-Related LncRNAs in Neuroblastoma: A Study Based on GEO and TARGET Datasets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.631546"}], "href": "https://doi.org/10.3389/fonc.2021.631546"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33767996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33767996"}]}]}]}