AJUBA Gene

Name	ajuba LIM protein
Description	Enables alpha-catenin binding activity and transcription corepressor activity. Involved in several processes, including miRNA-mediated gene silencing by inhibition of translation; negative regulation of hippo signaling; and regulation of cellular response to hypoxia. Acts upstream of or within miRNA-mediated post-transcriptional gene silencing and positive regulation of protein-containing complex assembly. Located in several cellular components, including Golgi apparatus; P-body; and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The AJUBA family of LIM domain–containing proteins functions as a versatile scaffold that integrates diverse cellular signals to regulate cell behavior. In several contexts, AJUBA coordinates Hippo pathway activity by facilitating YAP‐dependent control of proliferation and differentiation—for example, its expression is required for YAP‐mediated cell growth in lung epithelial progenitors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " At the plasma membrane and cell–cell junctions, AJUBA interacts with cytoskeletal components to couple mechanical tension and regulate Rac1 activity, thereby maintaining epithelial integrity and modulating cell morphology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, AJUBA plays an important mitotic role by localizing to centrosomes and kinetochores, where it associates with key checkpoint proteins such as Aurora kinase B and BUBR1 to ensure proper chromosome segregation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, acting as a nuclear co‐repressor through its interaction with the SNAG domain of Snail family transcription factors, AJUBA contributes to the epithelial–mesenchymal transition (EMT), thereby promoting migratory and invasive phenotypes in cancer cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": " Finally, AJUBA integrates inflammatory signals by participating in the assembly of an aPKC/p62/TRAF6 complex that enhances NF‐κB activation in response to interleukin‐1 stimulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies reveal that AJUBA serves as a multifaceted adaptor linking cell adhesion, mechanical cues, mitotic regulation, and transcriptional control. In doing so, it plays critical roles in governing cell proliferation, differentiation, migration, and tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "11"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alexander W Lange, Anusha Sridharan, Yan Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jmcb/mju046"}], "href": "https://doi.org/10.1093/jmcb/mju046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25480985"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25480985"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shumei Song, Soichiro Honjo, Jiankang Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-14-2191"}], "href": "https://doi.org/10.1158/1078-0432.CCR-14-2191"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25739674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25739674"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kim Baumann "}, {"type": "b", "children": [{"type": "t", "text": "Development. Mechanical forces linked to organ growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Rev Mol Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nrm3846"}], "href": "https://doi.org/10.1038/nrm3846"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25053357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25053357"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Cordelia Rauskolb, Estelle Cervantes, Ferralita Madere, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Organization and function of tension-dependent complexes at adherens junctions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.224063"}], "href": "https://doi.org/10.1242/jcs.224063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30837288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30837288"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Alexia Ferrand, Véronique Chevrier, Jean-Paul Chauvin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ajuba: a new microtubule-associated protein that interacts with BUBR1 and Aurora B at kinetochores in metaphase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BC20080060"}], "href": "https://doi.org/10.1042/BC20080060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18710370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18710370"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Dora Sabino, Nicholas H Brown, Renata Basto "}, {"type": "b", "children": [{"type": "t", "text": "Drosophila Ajuba is not an Aurora-A activator but is required to maintain Aurora-A at the centrosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.076711"}], "href": "https://doi.org/10.1242/jcs.076711"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21402878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21402878"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Teruyuki Sato, Atsushi Kaneda, Shingo Tsuji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep01911"}], "href": "https://doi.org/10.1038/srep01911"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23714854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23714854"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xing-Hua Liang, Guang-Xian Zhang, Yue-Bin Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LIM protein JUB promotes epithelial-mesenchymal transition in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.12404"}], "href": "https://doi.org/10.1111/cas.12404"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24673742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24673742"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Daming Yang, Tieying Hou, Lei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Smad1 promotes colorectal cancer cell migration through Ajuba transactivation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.22780"}], "href": "https://doi.org/10.18632/oncotarget.22780"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29299158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29299158"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yungfeng Feng, Gregory D Longmore "}, {"type": "b", "children": [{"type": "t", "text": "The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.10.4010-4022.2005"}], "href": "https://doi.org/10.1128/MCB.25.10.4010-4022.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15870274"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15870274"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Gongping Sun, Kenneth D Irvine "}, {"type": "b", "children": [{"type": "t", "text": "Ajuba family proteins link JNK to Hippo signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2004324"}], "href": "https://doi.org/10.1126/scisignal.2004324"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24023255"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24023255"}]}]}]}
Synonyms	JUB
Proteins	AJUBA_HUMAN
NCBI Gene ID	84962
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

AJUBA has 6,086 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 108 datasets.

Click the + buttons to view associations for AJUBA from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

AJUBA Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of AJUBA gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of AJUBA gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of AJUBA gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of AJUBA gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of AJUBA gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of AJUBA gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of AJUBA gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of AJUBA gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with AJUBA protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with AJUBA gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AJUBA gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of AJUBA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of AJUBA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing AJUBA protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing AJUBA protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing AJUBA protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing AJUBA protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with AJUBA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with AJUBA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of AJUBA gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with AJUBA gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with AJUBA gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with AJUBA gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of AJUBA protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by AJUBA gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with AJUBA gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with AJUBA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with AJUBA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with AJUBA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with AJUBA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at AJUBA gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AJUBA gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of AJUBA gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing AJUBA from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with AJUBA gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with AJUBA gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with AJUBA gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing AJUBA from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of AJUBA gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of AJUBA gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.