{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A‐kinase–interacting protein 1 (AKIP1), also known as breast cancer–associated protein 3 (BCA3), has emerged as a multifunctional adaptor that integrates diverse signaling pathways in both normal and disease states. AKIP1 directly binds the N‐terminal region of the protein kinase A (PKA) catalytic subunit, thereby promoting its nuclear translocation and modulating downstream gene transcription."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, AKIP1 interacts with the NF‑κB p65 subunit to enhance its phosphorylation, nuclear retention, and transcriptional competence. This activation of NF‑κB signaling contributes to the upregulation of proangiogenic factors (for example, vascular endothelial growth factor‑C), chemokines, and other genes that drive tumor progression in several malignancies—including esophageal, cervical, hepatocellular, non–small cell lung, glioma, and thyroid cancers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its role in regulating transcription factors, AKIP1 modulates key oncogenic cascades such as PI3K/AKT and epithelial–mesenchymal transition (EMT) pathways, thereby promoting cancer cell proliferation, migration, invasion, and metastasis in gastric and cervical tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In hematological malignancies such as acute myeloid leukemia and multiple myeloma, elevated AKIP1 levels correlate with increased expression of chemokines and with adverse prognostic features."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "18"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the cardiovascular system, stress stimuli upregulate AKIP1 expression, and its preferential localization to cardiac mitochondria is associated with reduced oxidative stress, improved calcium handling, and decreased cardiomyocyte apoptosis during ischemia–reperfusion injury."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "21"}]}, {"type": "t", "text": " Moreover, AKIP1 is subject to post‐translational modifications such as neddylation that influence its ability to repress NF‑κB–dependent gene expression through the recruitment of histone deacetylases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond cellular homeostasis and oncogenesis, AKIP1 is also exploited by viral pathogens. For instance, its interaction with the catalytic subunit of PKA is implicated in the incorporation of cellular proteins into HIV‑1 particles"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": ", while binding to Ebola virus VP35 leads to activation of the PKA–CREB1 axis, thereby facilitating viral replication and potentially contributing to virus‐associated hemorrhage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, AKIP1 interacts with small GTPases such as Rac1 in osteoclasts, thereby modulating actin cytoskeletal remodeling and cell spreading"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "25"}]}, {"type": "t", "text": ", further underscoring its versatile role as a signaling hub. Collectively, these studies indicate that AKIP1 integrates PKA signaling with NF‑κB–dependent transcription and other pathways to modulate stress responses, tumor progression, and viral pathogenesis. Its dysregulation is associated with adverse clinical outcomes in cancer, cardiovascular disease, and infectious settings, making AKIP1 a promising target for future therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}, {"type": "fg_f", "ref": "14"}, {"type": "fg_fs", "start_ref": "7", "end_ref": "12"}, {"type": "fg_f", "ref": "17"}, {"type": "fg_f", "ref": "13"}, {"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mira Sastri, David M Barraclough, Peter T Carmichael, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A-kinase-interacting protein localizes protein kinase A in the nucleus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0408608102"}], "href": "https://doi.org/10.1073/pnas.0408608102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15630084"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15630084"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Angela Yulia, Natasha Singh, Alice J Varley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PKA and AKIP1 interact to mediate cAMP-driven COX-2 expression: A potentially pivotal interaction in preterm and term labour."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0252720"}], "href": "https://doi.org/10.1371/journal.pone.0252720"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34166397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34166397"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Nan Gao, Yurina Hibi, Marni Cueno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A-kinase-interacting protein 1 (AKIP1) acts as a molecular determinant of PKA in NF-kappaB signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.116566"}], "href": "https://doi.org/10.1074/jbc.M110.116566"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20562110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20562110"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nan Gao, Kaori Asamitsu, Yurina Hibi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M710285200"}], "href": "https://doi.org/10.1074/jbc.M710285200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18178962"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18178962"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "C Lin, L Song, A Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of AKIP1 promotes angiogenesis and lymphangiogenesis in human esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.559"}], "href": "https://doi.org/10.1038/onc.2013.559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24413079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24413079"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiujuan Zhang, Shuxian Liu, Yongqing Zhu "}, {"type": "b", "children": [{"type": "t", "text": "A-kinase-interacting protein 1 promotes EMT and metastasis via PI3K/Akt/IKKβ pathway in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biochem Funct (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbf.3547"}], "href": "https://doi.org/10.1002/cbf.3547"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32401379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32401379"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Dong Ma, Mengquan Li, Jing Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BCA3 contributes to the malignant progression of hepatocellular carcinoma through AKT activation and NF-κB translocation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2017.11.011"}], "href": "https://doi.org/10.1016/j.yexcr.2017.11.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29133128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29133128"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yingchao Liu, Jia Tian, Dongrui Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AKIP1 expression in tumor tissue as a new biomarker for disease monitoring and prognosis in non-small cell lung cancer: Results of a retrospective study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23128"}], "href": "https://doi.org/10.1002/jcla.23128"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31782840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31782840"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Tao Fang, Qi Lu "}, {"type": "b", "children": [{"type": "t", "text": "A-kinase interacting protein 1 (AKIP1) associates with advanced overall disease condition, tumor properties, and unfavorable prognosis in hepatocellular carcinoma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23213"}], "href": "https://doi.org/10.1002/jcla.23213"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32133702"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32133702"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Luqing Zhang, Haiying Tao, Kongliang Ke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A-kinase interacting protein 1 as a potential biomarker of advanced tumor features and increased recurrence risk in papillary thyroid carcinoma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23452"}], "href": "https://doi.org/10.1002/jcla.23452"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32643206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32643206"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Songbo Shen, Yiqun Yao "}, {"type": "b", "children": [{"type": "t", "text": "A-kinase interacting protein 1 is sufficiently expressed and positively associates with WHO grade, meanwhile predicts unfavorable overall survival independently in glioma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000020426"}], "href": "https://doi.org/10.1097/MD.0000000000020426"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33530151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33530151"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Zhaohui Chen, Haitao Wen, Jinwei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of AKIP1 Suppresses the Proliferation, Migration, and Epithelial-Mesenchymal Transition Process of Glioma Cells by Upregulating DLG2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/5648011"}], "href": "https://doi.org/10.1155/2022/5648011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35111846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35111846"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ying Sun, Guang Shi, Chao Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of a kinase interacting protein 1 in tongue squamous cell carcinoma correlates with lymph node metastasis and poor overall survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000025278"}], "href": "https://doi.org/10.1097/MD.0000000000025278"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33832094"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33832094"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "T H-Y Leung, S C-S Wong, K K-L Chan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The interaction between C35 and ΔNp73 promotes chemo-resistance in ovarian cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/bjc.2013.397"}], "href": "https://doi.org/10.1038/bjc.2013.397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23880825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23880825"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Dehu Chen, Gan Cao, Qinghong Liu "}, {"type": "b", "children": [{"type": "t", "text": "A-kinase-interacting protein 1 facilitates growth and metastasis of gastric cancer cells via Slug-induced epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14339"}], "href": "https://doi.org/10.1111/jcmm.14339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31020809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31020809"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Xiaohong Hao, Mianmian Gu, Jie Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A-kinase interacting protein 1 might serve as a novel biomarker for worse prognosis through the interaction of chemokine (C-X-C motif) ligand 1/chemokine (C-X-C motif) ligand 2 in acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23052"}], "href": "https://doi.org/10.1002/jcla.23052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31617252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31617252"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yan Yan, Xiaoyan Li, Jie Gao "}, {"type": "b", "children": [{"type": "t", "text": "Identification of A-kinase interacting protein 1 as a potential biomarker for risk and prognosis of acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23055"}], "href": "https://doi.org/10.1002/jcla.23055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32356617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32356617"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Wei Wang, Yinghua Xie, Xiyao Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Correlation of A-Kinase Interacting Protein 1 With Clinical Features, Treatment Response, and Survival Profiles in Patients With Multiple Myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033820935856"}], "href": "https://doi.org/10.1177/1533033820935856"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32799782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32799782"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Zhi-Qiang Tian, Hong Jiang, Zhi-Bing Lu "}, {"type": "b", "children": [{"type": "t", "text": "MiR-320 regulates cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s11658-018-0105-1"}], "href": "https://doi.org/10.1186/s11658-018-0105-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30181740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30181740"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Hiroshi Magome, Takahito Nomura, Atsushi Hanada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CYP714B1 and CYP714B2 encode gibberellin 13-oxidases that reduce gibberellin activity in rice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1215788110"}], "href": "https://doi.org/10.1073/pnas.1215788110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23319637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23319637"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Harmen G Booij, Hongjuan Yu, Rudolf A De Boer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of A kinase interacting protein 1 attenuates myocardial ischaemia/reperfusion injury but does not influence heart failure development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvw161"}], "href": "https://doi.org/10.1093/cvr/cvw161"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27302402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27302402"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Fei Gao, Jinke Cheng, Tong Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFkappaB-dependent transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1483"}], "href": "https://doi.org/10.1038/ncb1483"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16998474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16998474"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Michaela Rumlová, Ivana Křížová, Jaroslav Zelenka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Does BCA3 Play a Role in the HIV-1 Replication Cycle?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Viruses (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/v10040212"}], "href": "https://doi.org/10.3390/v10040212"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29677171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29677171"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Lin Zhu, Ting Gao, Yi Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ebola virus VP35 hijacks the PKA-CREB1 pathway for replication and pathogenesis by AKIP1 association."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-022-29948-4"}], "href": "https://doi.org/10.1038/s41467-022-29948-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35474062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35474062"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Kuan-ping Yu, Takashi Itokawa, Mei-ling Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Breast cancer-associated gene 3 (BCA3) is a novel Rac1-interacting protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1359/jbmr.070105"}], "href": "https://doi.org/10.1359/jbmr.070105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17227220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17227220"}]}]}]}