AKIRIN1 Gene

Name	akirin 1
Description	Predicted to enable transcription coregulator activity. Predicted to be involved in several processes, including myoblast migration involved in skeletal muscle regeneration; negative regulation of satellite cell differentiation; and positive regulation of lamellipodium assembly. Located in nuclear membrane and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Akirin1 is a small, highly conserved nuclear protein that functions as a transcriptional cofactor, acting as a “molecular bridge” between sequence‐specific transcription factors and chromatin remodeling complexes to regulate context‐dependent gene expression. In skeletal muscle, Akirin1 plays a critical role in myogenesis by promoting satellite cell activation and myoblast differentiation. Its expression is low in quiescent cells and becomes up‐regulated upon activation, where it assists in reorganizing the actin cytoskeleton and stimulating the transcription of myogenic regulatory factors such as MyoD, Myogenin, and MRF4. Moreover, modulation of Akirin1 levels—through signals such as myostatin and glucocorticoids—has been linked to altered satellite cell function, muscle regeneration, and atrophy, suggesting that the proper regulation of Akirin1 is essential for muscle growth and repair (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its role in myogenesis, Akirin1 is also implicated in innate immune responses. Studies in diverse species have shown that Akirin1 (or its orthologues) is rapidly induced following bacterial or viral challenges and functions within NF‐κB–dependent signaling pathways. By facilitating the recruitment of chromatin remodeling complexes, Akirin1 helps to orchestrate the expression of a selective subset of immune response genes. Thus, through its bridging role, Akirin1 contributes to the fine‐tuning of transcriptional responses necessary for both host defense and tissue homeostasis (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, Akirin1’s capacity to physically interact with key transcription factors – for instance, its cooperation with the muscle‐determining factor Twist through association with SWI/SNF (Brahma) complexes – underscores its central role in coupling transcription factor activity with chromatin accessibility. This dual function in both muscle development and immune regulation positions Akirin1 as a pivotal mediator of gene expression programs essential for proper cellular differentiation and the maintenance of genomic integrity (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanjun Dong, Jenny S Pan, Liping Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Myostatin suppression of Akirin1 mediates glucocorticoid-induced satellite cell dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0058554"}], "href": "https://doi.org/10.1371/journal.pone.0058554"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23516508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23516508"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mônica Senna Salerno, Kelly Dyer, Jeremy Bracegirdle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Akirin1 (Mighty), a novel promyogenic factor regulates muscle regeneration and cell chemotaxis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2009.04.014"}], "href": "https://doi.org/10.1016/j.yexcr.2009.04.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19406121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19406121"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wenqiang Sun, Shenqiang Hu, Jiwei Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Akirin1 promotes myoblast differentiation by modulating multiple myoblast differentiation factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20182152"}], "href": "https://doi.org/10.1042/BSR20182152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30777932"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30777932"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chang-Geng Yang, Xian-Li Wang, Lei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A new Akirin1 gene in turbot (Scophthalmus maximus): molecular cloning, characterization and expression analysis in response to bacterial and viral immunological challenge."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Fish Shellfish Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.fsi.2011.01.028"}], "href": "https://doi.org/10.1016/j.fsi.2011.01.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21300161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21300161"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Akira Goto, Kazufumi Matsushita, Viola Gesellchen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni1543"}], "href": "https://doi.org/10.1038/ni1543"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18066067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18066067"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Chang-Geng Yang, Xian-Li Wang, Bo Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Screening and analysis of PoAkirin1 and two related genes in response to immunological stimulants in the Japanese flounder (Paralichthys olivaceus)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Mol Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2199-14-10"}], "href": "https://doi.org/10.1186/1471-2199-14-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23651673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23651673"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Scott J Nowak, Hitoshi Aihara, Katie Gonzalez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Akirin links twist-regulated transcription with the Brahma chromatin remodeling complex during embryogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1002547"}], "href": "https://doi.org/10.1371/journal.pgen.1002547"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22396663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22396663"}]}]}]}
Synonyms	C1ORF108, STRF2
Proteins	AKIR1_HUMAN
NCBI Gene ID	79647
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

AKIRIN1 has 6,694 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 102 datasets.

Click the + buttons to view associations for AKIRIN1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

AKIRIN1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of AKIRIN1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of AKIRIN1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of AKIRIN1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of AKIRIN1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of AKIRIN1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of AKIRIN1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of AKIRIN1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of AKIRIN1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of AKIRIN1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of AKIRIN1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of AKIRIN1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of AKIRIN1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with AKIRIN1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AKIRIN1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of AKIRIN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of AKIRIN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing AKIRIN1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of AKIRIN1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing AKIRIN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing AKIRIN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing AKIRIN1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing AKIRIN1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with AKIRIN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with AKIRIN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of AKIRIN1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with AKIRIN1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with AKIRIN1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with AKIRIN1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by AKIRIN1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with AKIRIN1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with AKIRIN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with AKIRIN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at AKIRIN1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AKIRIN1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of AKIRIN1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing AKIRIN1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing AKIRIN1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of AKIRIN1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of AKIRIN1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of AKIRIN1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.