{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma (HCC), the long noncoding RNA ALKBH3‐AS1 is aberrantly overexpressed in tumor tissues and HCC cell lines, with its elevated expression levels correlating with poorer patient survival. Notably, ALKBH3‐AS1 is distributed in both the nucleus and cytoplasm of HCC cells, suggesting multiple cellular roles in gene regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFunctional studies demonstrate that knockdown of ALKBH3‐AS1 suppresses HCC cell invasion, proliferation, and overall tumor growth in vivo, while its overexpression enhances these oncogenic features. These experiments indicate that ALKBH3‐AS1 acts as an oncogene in the context of liver cancer, modulating key processes of tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, ALKBH3‐AS1 plays a pivotal role in governing the stability of ALKBH3 mRNA; its silencing reduces ALKBH3 expression by destabilizing the transcript, and the similar phenotypic effects observed upon ALKBH3 knockdown further underscore this functional link. Moreover, under hypoxic conditions, the transcription factor HIF-1α upregulates ALKBH3‐AS1 expression, thereby amplifying its oncogenic impact in HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qiliang Lu, Hao Wang, Xiangxiang Lei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ALKBH3-AS1 enhances ALKBH3 mRNA stability to promote hepatocellular carcinoma cell proliferation and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.17558"}], "href": "https://doi.org/10.1111/jcmm.17558"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36098205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36098205"}]}]}]}