{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ALMS1‐IT1 is a long non‐coding RNA that appears to have multifaceted roles in both cancer progression and neuroinflammatory processes. In colorectal cancer, ALMS1‐IT1 is one of several ferroptosis‐related lncRNAs whose increased expression is associated with poor patient prognosis, suggesting that it may be involved in pathways critical to tumor survival and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of cerebral ischemia, ALMS1‐IT1 is rapidly up‐regulated after injury; its knockdown leads to reduced expression of pro‐inflammatory cytokines and improved sensorimotor and spatial learning outcomes through suppression of NF‐κB signaling, indicating a role in modulating neuro-inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In lung adenocarcinoma, overexpression of ALMS1‐IT1, in conjunction with its positively correlated partner AVL9, promotes cancer cell proliferation, migration, and invasion via activation of the cyclin-dependent kinase pathway, pointing to a contribution to malignant progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in head and neck squamous cell carcinoma, ALMS1‐IT1 is included in a multi‑lncRNA risk model where its elevated levels correlate with poorer overall survival and are linked to metabolic as well as immune regulatory pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Finally, in small‑cell lung cancer, ALMS1‐IT1 forms part of a competing endogenous RNA network alongside other lncRNAs and alternative splicing events, underscoring its potential as a biomarker and suggesting a role in the disease’s pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies indicate that ALMS1‐IT1 is a critical regulator of key signaling cascades—including those governing cell cycle progression, inflammatory responses, and metabolic pathways—that drive both tumor progression and neurodegenerative processes. Its consistent association with poor prognosis and aggressive disease features across multiple conditions points to its potential utility as a prognostic biomarker and as a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Na Li, Jiangli Shen, Ximin Qiao, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The lncRNA ALMS1-IT1 may promote malignant progression of lung adenocarcinoma via AVL9-mediated activation of the cyclin-dependent kinase pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Open Bio (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/2211-5463.13140"}], "href": "https://doi.org/10.1002/2211-5463.13140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33683834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33683834"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lu Xing, Xiaoqian Zhang, Anwei Chen "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic 4-lncRNA-based risk model predicts survival time of patients with head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2019.10670"}], "href": "https://doi.org/10.3892/ol.2019.10670"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31452809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31452809"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Youming Lei, Yunfei Shi, Jin Duan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of alternative splicing and lncRNA genes in pathogenesis of small cell lung cancer based on their RNA sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Clin Exp Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.17219/acem/94392"}], "href": "https://doi.org/10.17219/acem/94392"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31403267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31403267"}]}]}]}