{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ALOX12-AS1 is a long non‐coding RNA that overlaps the ALOX12 gene, which encodes a key enzyme responsible for generating bioactive lipid mediators involved in inflammation and the pathogenesis of several human diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Detailed investigation into its molecular mechanism has revealed that ALOX12-AS1 is ubiquitously expressed as two major isoforms localized in both the nucleus and cytoplasm. Notably, upon specific cellular stimulation, it translocates between these compartments and forms an RNA duplex with the sense ALOX12 mRNA, ultimately downregulating ALOX12 protein translation by associating with ribosomal proteins."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in the context of cervical cancer, ALOX12-AS1 is found to be downregulated, and its overexpression inhibits cancer cell proliferation. Mechanistically, ALOX12-AS1 interacts with AGO2 to sponge miR-3171, thereby relieving miR-3171-mediated suppression of the tumor suppressor PTEN, contributing to its anti-tumor effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " These studies collectively introduce a novel regulatory function for ALOX12-AS1 in modulating both lipid metabolism–linked inflammatory pathways and tumorigenesis, highlighting its potential as a prognostic and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nikhlesh K Singh, Gadiparthi N Rao "}, {"type": "b", "children": [{"type": "t", "text": "Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prog Lipid Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.plipres.2018.11.001"}], "href": "https://doi.org/10.1016/j.plipres.2018.11.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30472260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30472260"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mohammad Golam Sabbir, Carla G Taylor, Peter Zahradka "}, {"type": "b", "children": [{"type": "t", "text": "Antisense overlapping long non-coding RNA regulates coding arachidonate 12-lipoxygenase gene by translational interference."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Biol Lipids (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbalip.2021.158987"}], "href": "https://doi.org/10.1016/j.bbalip.2021.158987"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34174394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34174394"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Weiwei Yang, Xiaoyan Wang, Shujie Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA ALOX12-AS1 inhibits cervical cancer cells proliferation via targeting miR-3171."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Drugs (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CAD.0000000000001214"}], "href": "https://doi.org/10.1097/CAD.0000000000001214"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34407056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34407056"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ming Tan, Ove B Schaffalitzky de Muckadell, Maiken Thyregod Jøergensen "}, {"type": "b", "children": [{"type": "t", "text": "Gene Expression Network Analysis of Precursor Lesions in Familial Pancreatic Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pancreat Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/pancan.2020.0007"}], "href": "https://doi.org/10.1089/pancan.2020.0007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32783019"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32783019"}]}]}]}