| Name | alkaline phosphatase, germ cell |
| Description | There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ALPPL2 is a cell surface alkaline phosphatase–related glycoprotein with an oncofetal expression pattern that plays multifaceted roles in both tumor biology and early embryonic development. In several cancer models, ALPPL2 is ectopically expressed and contributes functionally to tumor cell growth and invasion. For instance, in pancreatic cancer, RNA interference–mediated knockdown of ALPPL2 diminished cell growth and invasive capacities, thereby highlighting its value as a diagnostic marker and potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Its high specificity is also demonstrated in mesothelioma and gastric adenocarcinoma, where elevated ALPPL2 expression correlates with aggressive disease and prognostic outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, during early human embryogenesis, ALPPL2 serves a critical function in maintaining naive pluripotency. Studies in human pluripotent stem cells have shown that ALPPL2 is a naive‐specific surface marker required for both the establishment and maintenance of the pluripotent state. Mechanistically, ALPPL2 interacts with the RNA-binding protein IGF2BP1 to stabilize mRNAs of key transcription factors such as TFCP2L1 and STAT3, thereby promoting a transcriptional network that supports naive pluripotency."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, genetic studies have revealed that sequence variations near ALPPL2 can influence drug pharmacokinetics. For example, single-nucleotide polymorphisms in the ALPPL2 genomic region have been associated with altered expression of anastrozole influx transporters and consequential differences in plasma anastrozole levels in breast cancer patients, suggesting a role in modulating drug response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore the dual role of ALPPL2 as both a functional regulator of cellular state in early development and a clinically useful biomarker in various malignancies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Pooja Dua, Hye Suk Kang, Seung-Mo Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alkaline phosphatase ALPPL-2 is a novel pancreatic carcinoma-associated protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-12-3682"}], "href": "https://doi.org/10.1158/0008-5472.CAN-12-3682"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23467613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23467613"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yang Su, Xin Zhang, Scott Bidlingmaier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ALPPL2 Is a Highly Specific and Targetable Tumor Cell Surface Antigen."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-20-1418"}], "href": "https://doi.org/10.1158/0008-5472.CAN-20-1418"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32868383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32868383"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shuang Liu, Qinsheng Mao, Wanjiang Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of ALPPL2 is associated with poor prognosis in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Pathol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humpath.2018.11.019"}], "href": "https://doi.org/10.1016/j.humpath.2018.11.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30496798"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30496798"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hanshuang Li, Chunshen Long, Jinzhu Xiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dppa2/4 as a trigger of signaling pathways to promote zygote genome activation by binding to CG-rich region."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brief Bioinform (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/bib/bbaa342"}], "href": "https://doi.org/10.1093/bib/bbaa342"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33316032"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33316032"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yan Bi, Zhifen Tu, Yanping Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of ALPPL2 as a Naive Pluripotent State-Specific Surface Protein Essential for Human Naive Pluripotency Regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2020.02.090"}], "href": "https://doi.org/10.1016/j.celrep.2020.02.090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32187559"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32187559"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Tanda M Dudenkov, Duan Liu, Junmei Cairns, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Pharmacol Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cpt.1359"}], "href": "https://doi.org/10.1002/cpt.1359"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30648747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30648747"}]}]}]}
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| NCBI Gene ID | 251 |
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| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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ALPG has 2,821 functional associations with biological entities spanning 5 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 32 datasets.
Click the + buttons to view associations for ALPG from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ALPG gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of ALPG gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with ALPG gene from the CellMarker Gene-Cell Type Associations dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of ALPG gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing ALPG protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with ALPG protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by ALPG gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DGIdb Drug Targets 2026 | interacting drugs for ALPG protein from the DGIdb Drug Targets 2026 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with ALPG gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with ALPG gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with ALPG gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with ALPG gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| GlyGen Glycosylated Proteins | ligands (chemical) binding ALPG protein from the GlyGen Glycosylated Proteins dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving ALPG gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by ALPG gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by ALPG gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of ALPG gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with ALPG gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of ALPG gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving ALPG protein from the KEGG Pathways 2026 dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of ALPG gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of ALPG gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of ALPG gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving ALPG protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2024 | pathways involving ALPG protein from the Reactome Pathways 2024 dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of ALPG gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of ALPG gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of ALPG gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ALPG protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ALPG protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with ALPG protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving ALPG protein from the WikiPathways Pathways 2024 dataset. | |
