AMOTL1 Gene

Name	angiomotin like 1
Description	The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n AMOTL1 is a multifunctional scaffolding protein of the angiomotin family that integrates signals from cell–cell junctions and the actin cytoskeleton to control the activity and subcellular localization of key transcriptional regulators, such as YAP and TAZ. In several studies, AMOTL1 has been shown to bind directly to the WW domains of YAP/TAZ through its PPxY motifs, thereby sequestering these oncogenic co‐activators in the cytoplasm and inhibiting their nuclear functions; such cytoplasmic retention downregulates pro‐proliferative and anti‐apoptotic gene programs."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In response to metabolic or other cellular stresses, AMOTL1 can be phosphorylated—for example, AMPK directly phosphorylates AMOTL1 at serine 793, an event that stabilizes the protein and further contributes to its ability to restrain YAP activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Additionally, by interacting with F‐actin in a competitive manner with YAP, AMOTL1 links cytoskeletal dynamics to Hippo pathway signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in Hippo signaling, AMOTL1 also participates in the regulation of cell polarity and migration. In endothelial cells, distinct isoforms of AMOTL1 contribute to the stabilization of tight junctions and the coordinated polarization of cells during angiogenesis, thereby influencing directional migration in vascular development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of cancer, dysregulation of AMOTL1 has been linked to tumorigenesis. In gastric cancer, for instance, increased AMOTL1 expression has been associated with the protection of YAP from ubiquitin‐mediated degradation and enhanced nuclear accumulation of YAP, which in turn leads to transcriptional activation of oncogenic targets such as CTGF. Conversely, a circular RNA derived from the AMOTL1 gene (circAMOTL1L) has been implicated in prostate cancer, where it functions as a microRNA sponge to inhibit EMT and suppress tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings position AMOTL1 as a critical integrator of mechanical, metabolic, and polarity signals that modulate YAP/TAZ activity and thereby influence cellular proliferation, migration, and fate determination in both normal development and disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Siew Wee Chan, Chun Jye Lim, Yaan Fun Chong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hippo pathway-independent restriction of TAZ and YAP by angiomotin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C110.212621"}], "href": "https://doi.org/10.1074/jbc.C110.212621"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21224387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21224387"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wenqi Wang, Jun Huang, Junjie Chen "}, {"type": "b", "children": [{"type": "t", "text": "Angiomotin-like proteins associate with and negatively regulate YAP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C110.205401"}], "href": "https://doi.org/10.1074/jbc.C110.205401"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21187284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21187284"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "T Oka, A P Schmitt, M Sudol "}, {"type": "b", "children": [{"type": "t", "text": "Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.216"}], "href": "https://doi.org/10.1038/onc.2011.216"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21685940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21685940"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Michael DeRan, Jiayi Yang, Che-Hung Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2014.09.036"}], "href": "https://doi.org/10.1016/j.celrep.2014.09.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25373897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25373897"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sebastian Mana-Capelli, Murugan Paramasivam, Shubham Dutta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Angiomotins link F-actin architecture to Hippo pathway signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E13-11-0701"}], "href": "https://doi.org/10.1091/mbc.E13-11-0701"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24648494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24648494"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yujuan Zheng, Simona Vertuani, Staffan Nyström, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.109.195156"}], "href": "https://doi.org/10.1161/CIRCRESAHA.109.195156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19590046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19590046"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yuhang Zhou, Jinglin Zhang, Hui Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-020-1293-5"}], "href": "https://doi.org/10.1038/s41388-020-1293-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32313226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32313226"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Dan Liu, Xiao-Xue Zhang, Meng-Chen Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-03590-5"}], "href": "https://doi.org/10.1038/s41467-018-03590-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29712898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29712898"}]}]}]}
Synonyms	JEAP
Proteins	AMOL1_HUMAN
NCBI Gene ID	154810
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

AMOTL1 has 6,381 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 115 datasets.

Click the + buttons to view associations for AMOTL1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

AMOTL1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of AMOTL1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of AMOTL1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of AMOTL1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of AMOTL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of AMOTL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of AMOTL1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of AMOTL1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of AMOTL1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of AMOTL1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of AMOTL1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with AMOTL1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with AMOTL1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AMOTL1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of AMOTL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of AMOTL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing AMOTL1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing AMOTL1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing AMOTL1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing AMOTL1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing AMOTL1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with AMOTL1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with AMOTL1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing AMOTL1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of AMOTL1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with AMOTL1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with AMOTL1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with AMOTL1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of AMOTL1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by AMOTL1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with AMOTL1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with AMOTL1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with AMOTL1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with AMOTL1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at AMOTL1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AMOTL1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of AMOTL1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing AMOTL1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with AMOTL1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with AMOTL1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with AMOTL1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.