ANKRD2 Gene

HGNC Family	Ankyrin repeat domain containing (ANKRD)
Name	ankyrin repeat domain 2 (stretch responsive muscle)
Description	This gene encodes a protein that belongs to the muscle ankyrin repeat protein (MARP) family. A similar gene in rodents is a component of a muscle stress response pathway and plays a role in the stretch-response associated with slow muscle function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ANKRD2 (also known as ARPP) is a member of the muscle ankyrin repeat protein (MARP) family that functions as both a structural and signaling molecule in striated muscle. In healthy muscle, ANKRD2 is enriched at the I‐band of the sarcomere through its association with titin, where it is thought to contribute to mechanosensing. Under conditions of mechanical stress, injury, or pathological remodeling such as in dilated cardiomyopathy, ANKRD2 is upregulated and translocates from the sarcomere to the nucleus, thereby linking extracellular mechanical stimuli to changes in gene expression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In the nucleus, ANKRD2 interacts with various transcription factors—including p53, YB‐1, and PML—to modulate the expression of muscle-specific genes and stress response pathways. In addition, ANKRD2 is a substrate of Akt2: its phosphorylation at Ser‑99 in response to oxidative stress appears to delay myogenic differentiation, suggesting a role for ANKRD2 in fine-tuning the balance between muscle repair and differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, ANKRD2 interacts with inhibitors of differentiation such as ID3, and its altered expression levels contribute to impaired myoblast fusion in disease models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Further emphasizing its role in muscle homeostasis and inflammatory regulation, ANKRD2 has been shown to repress proinflammatory gene expression via interactions with the NF‑κB p50 subunit"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and gene silencing studies indicate that it modulates multiple intracellular signaling cascades (e.g., MAPK, cytokine, and insulin pathways) that are essential for coordinated cellular responses to stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Finally, while most studies have focused on its role in skeletal muscle, emerging evidence suggests that ANKRD2 may also contribute to cardiac muscle remodeling and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sherif F Nagueh, Gopi Shah, Yiming Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.CIR.0000135591.37759.AF"}], "href": "https://doi.org/10.1161/01.CIR.0000135591.37759.AF"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15238456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15238456"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Snezana Kojic, Elisa Medeot, Ernesto Guccione, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2004.03.071"}], "href": "https://doi.org/10.1016/j.jmb.2004.03.071"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15136035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15136035"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yoshiyuki Tsukamoto, Naoki Hijiya, Shinji Yano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arpp/Ankrd2, a member of the muscle ankyrin repeat proteins (MARPs), translocates from the I-band to the nucleus after muscle injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histochem Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00418-007-0348-9"}], "href": "https://doi.org/10.1007/s00418-007-0348-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17926058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17926058"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Vittoria Cenni, Alberto Bavelloni, Francesca Beretti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E10-11-0928"}], "href": "https://doi.org/10.1091/mbc.E10-11-0928"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21737686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21737686"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Camilla Bean, Michela Salamon, Anna Raffaello, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Ankrd2, Cdkn1c and calcyclin genes are under the control of MyoD during myogenic differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2005.03.063"}], "href": "https://doi.org/10.1016/j.jmb.2005.03.063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15890200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15890200"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Danielle Buck, John E Smith, Charles S Chung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gen Physiol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1085/jgp.201311129"}], "href": "https://doi.org/10.1085/jgp.201311129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24470489"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24470489"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Anna Belgrano, Ljiljana Rakicevic, Lorenza Mittempergher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multi-tasking role of the mechanosensing protein Ankrd2 in the signaling network of striated muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0025519"}], "href": "https://doi.org/10.1371/journal.pone.0025519"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22016770"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22016770"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jovana Jasnic-Savovic, Aleksandra Nestorovic, Slobodan Savic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Profiling of skeletal muscle Ankrd2 protein in human cardiac tissue and neonatal rat cardiomyocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histochem Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00418-015-1307-5"}], "href": "https://doi.org/10.1007/s00418-015-1307-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25585647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25585647"}]}]}]}
Synonyms	ARPP
Proteins	ANKR2_HUMAN
NCBI Gene ID	26287
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ANKRD2 has 5,527 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 110 datasets.

Click the + buttons to view associations for ANKRD2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ANKRD2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ANKRD2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ANKRD2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ANKRD2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ANKRD2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ANKRD2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ANKRD2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ANKRD2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ANKRD2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ANKRD2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ANKRD2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ANKRD2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ANKRD2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ANKRD2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ANKRD2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ANKRD2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of ANKRD2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ANKRD2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ANKRD2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ANKRD2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ANKRD2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ANKRD2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ANKRD2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ANKRD2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ANKRD2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ANKRD2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ANKRD2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ANKRD2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ANKRD2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ANKRD2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ANKRD2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ANKRD2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ANKRD2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ANKRD2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ANKRD2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ANKRD2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ANKRD2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ANKRD2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with ANKRD2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ANKRD2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ANKRD2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.