{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have revealed that the long non‐coding RNA ANXA2R-OT1 (also referred to as LOC648987) acts as an oncogenic driver in renal cell carcinoma. Evidence indicates that high expression of ANXA2R-OT1 strongly correlates with enhanced tumor cell proliferation and metastatic behavior. In experimental models, silencing this lncRNA in RCC cell lines (ACHN and 786-O) arrested the cell cycle at the G0/G1 phase, reduced colony formation, and significantly induced apoptosis, thereby hindering tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, the tumor-promoting activity of ANXA2R-OT1 appears to be mediated through the regulation of epithelial–mesenchymal transition via factors such as vimentin and MMP-9. This regulatory influence not only facilitates cell migration but also contributes to increased metastasis and tumorigenesis in vivo, highlighting ANXA2R-OT1 as a potential therapeutic target for managing RCC progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yaowu Su, Liang Zhou, Qin Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-Coding RNA LOC648987 Promotes Proliferation and Metastasis of Renal Cell Carcinoma by Regulating Epithelial-Mesenchymal Transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033821997834"}], "href": "https://doi.org/10.1177/1533033821997834"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33858283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33858283"}]}]}]}