{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n APCDD1L‐AS1 has emerged as a multifaceted long non‐coding RNA involved in cancer progression and therapy resistance. In lung squamous cell carcinoma, APCDD1L‐AS1 was part of a prognostic risk model and its co‐expression network—with genes implicated in positive regulation of cell migration and extracellular matrix organization—suggests a role in modulating tumor behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In oral squamous cell carcinoma, high APCDD1L‐AS1 expression was associated with 5‐fluorouracil resistance and poorer patient prognosis, indicating that this lncRNA contributes to acquired chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in lung adenocarcinoma, APCDD1L‐AS1 was identified as the most significantly upregulated lncRNA in icotinib‐resistant cells. It promoted resistance by acting as a competing endogenous RNA, sponging miR‑1322, miR‑1972, and miR‑324‑3p to relieve suppression of SIRT5. Elevated SIRT5 then inhibited the autophagic degradation of EGFR, resulting in increased EGFR expression and sustained drug resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies highlight APCDD1L‐AS1 as a critical regulator of cancer cell migration and drug resistance, underscoring its potential utility as a biomarker for prognosis and as a therapeutic target across different cancer types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanzhuo Luo, Zhaobo Xuan, Xiaofeng Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs RP5-821D11.7, APCDD1L-AS1 and RP11-277P12.9 were associated with the prognosis of lung squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.8770"}], "href": "https://doi.org/10.3892/mmr.2018.8770"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29568882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29568882"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shen Li, Zhiyan Shi, Suwei Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal-mediated transfer of APCDD1L-AS1 induces 5-fluorouracil resistance in oral squamous cell carcinoma via miR-1224-5p/nuclear receptor binding SET domain protein 2 (NSD2) axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1979442"}], "href": "https://doi.org/10.1080/21655979.2021.1979442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34546854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34546854"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jie Wu, Chunlei Zheng, Yizhe Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA APCDD1L-AS1 induces icotinib resistance by inhibition of EGFR autophagic degradation via the miR-1322/miR-1972/miR-324-3p-SIRT5 axis in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomark Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40364-021-00262-3"}], "href": "https://doi.org/10.1186/s40364-021-00262-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33516270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33516270"}]}]}]}