{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAPCDD1L‐AS1, a long non‐coding RNA identified in lung squamous cell carcinoma (LUSC), appears to participate in regulating tumor behavior. In a prognostic risk model for LUSC, APCDD1L‐AS1 was one of three lncRNAs whose expression levels were significantly altered when compared with adjacent non‐tumor tissues. Co‐expression analysis revealed that APCDD1L‐AS1 is linked with genes that play roles in the positive regulation of cell migration and in maintaining the proteinaceous extracellular matrix, suggesting that it may influence tumor cell motility and microenvironment interactions, thereby affecting patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn oral squamous cell carcinoma (OSCC), APCDD1L‐AS1 has been directly implicated in the development of chemoresistance to 5‐fluorouracil (5‐FU). Elevated levels of APCDD1L‐AS1 were observed in OSCC tissues and cell lines that had acquired resistance to 5‐FU. Functional studies demonstrated that knockdown of APCDD1L‐AS1 reduced the IC50 of 5‐FU, decreased cell viability, and promoted apoptosis in resistant cells. Further mechanistic investigations uncovered that APCDD1L‐AS1 exerts its effects via an exosome‐mediated transfer, where it acts as a molecular sponge for miR‐1224‐5p. This sequestration leads to the upregulation of NSD2, a downstream effector that contributes to the chemoresistant phenotype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanzhuo Luo, Zhaobo Xuan, Xiaofeng Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs RP5-821D11.7, APCDD1L-AS1 and RP11-277P12.9 were associated with the prognosis of lung squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.8770"}], "href": "https://doi.org/10.3892/mmr.2018.8770"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29568882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29568882"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shen Li, Zhiyan Shi, Suwei Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal-mediated transfer of APCDD1L-AS1 induces 5-fluorouracil resistance in oral squamous cell carcinoma via miR-1224-5p/nuclear receptor binding SET domain protein 2 (NSD2) axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1979442"}], "href": "https://doi.org/10.1080/21655979.2021.1979442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34546854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34546854"}]}]}]}