| HGNC Family | Endogenous ligands |
| Name | apelin |
| Description | This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. [provided by RefSeq, Feb 2016] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Apelin, an endogenous peptide ligand for the G protein–coupled receptor APJ, has emerged as a pivotal regulator of cardiovascular function, vascular remodeling, and metabolic homeostasis. Apelin is efficiently cleaved by angiotensin‐converting enzyme 2 (ACE2), revealing an important interplay with the renin–angiotensin system."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the cardiovascular system, apelin exerts potent positive inotropic effects and endothelium‐dependent vasodilation that counteract angiotensin II–mediated vasoconstriction and contribute to blood pressure regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "9"}]}, {"type": "t", "text": " Moreover, apelin promotes angiogenesis and vascular remodeling—not only by regulating vessel caliber during embryogenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "but also by enhancing therapeutic neovascularization in ischemic tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Metabolically, apelin is secreted by adipocytes under the direct control of insulin and nutritional status, linking elevated apelin levels to conditions of obesity and insulin resistance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "16"}]}, {"type": "t", "text": " In parallel, apelin enhances whole‐body glucose utilization and improves insulin sensitivity in skeletal muscle and adipose tissue."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}, {"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " Additionally, disruption of the apelin/APJ system adversely affects pulmonary vascular homeostasis, as evidenced by exacerbated pulmonary arterial hypertension and atherosclerotic changes—effects linked to altered nitric oxide signaling, AMP‐activated protein kinase activation, and oxidative stress in vascular cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": " Induction of apelin expression by hypoxia via HIF‐1α further underscores its role in adaptive vascular responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": " Collectively, these findings establish apelin as a critical endocrine and paracrine mediator that integrates cardiovascular regulation, angiogenesis, and metabolic control, thereby offering a promising therapeutic target for cardiovascular and metabolic disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}, {"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chad Vickers, Paul Hales, Virendar Kaushik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M200581200"}], "href": "https://doi.org/10.1074/jbc.M200581200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11815627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11815627"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Teruki Sato, Takashi Suzuki, Hiroyuki Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apelin is a positive regulator of ACE2 in failing hearts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI69608"}], "href": "https://doi.org/10.1172/JCI69608"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24177423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24177423"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Junji Ishida, Tatsuo Hashimoto, Yasumi Hashimoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M404149200"}], "href": "https://doi.org/10.1074/jbc.M404149200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15087458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15087458"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mary M Chen, Euan A Ashley, David X F Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.CIR.0000091235.94914.75"}], "href": "https://doi.org/10.1161/01.CIR.0000091235.94914.75"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12963638"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12963638"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Alan G Japp, Nicholas L Cruden, David A B Amer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vascular effects of apelin in vivo in man."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Coll Cardiol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jacc.2008.06.013"}], "href": "https://doi.org/10.1016/j.jacc.2008.06.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18772060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18772060"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Janet J Maguire, Matthias J Kleinz, Sarah L Pitkin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Pyr1]apelin-13 identified as the predominant apelin isoform in the human heart: vasoactive mechanisms and inotropic action in disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/HYPERTENSIONAHA.109.134619"}], "href": "https://doi.org/10.1161/HYPERTENSIONAHA.109.134619"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19597036"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19597036"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Gábor Földes, Ferenc Horkay, István Szokodi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-291x(03)01424-4"}], "href": "https://doi.org/10.1016/s0006-291x(03"}, {"type": "t", "text": "01424-4) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12914775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12914775"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yujung Kang, Jongmin Kim, Joshua P Anderson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.113.301324"}], "href": "https://doi.org/10.1161/CIRCRESAHA.113.301324"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23603510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23603510"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xiao-Hua Yu, Zhi-Bin Tang, Li-Jing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apelin and its receptor APJ in cardiovascular diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Chim Acta (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cca.2013.09.001"}], "href": "https://doi.org/10.1016/j.cca.2013.09.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24055369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24055369"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hiroyasu Kidoya, Masaya Ueno, Yoshihiro Yamada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601982"}], "href": "https://doi.org/10.1038/sj.emboj.7601982"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18200044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18200044"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Atsushi Kasai, Norihito Shintani, Hideaki Kato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Retardation of retinal vascular development in apelin-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.108.163402"}], "href": "https://doi.org/10.1161/ATVBAHA.108.163402"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18599802"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18599802"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hiroyasu Kidoya, Hisamichi Naito, Nobuyuki Takakura "}, {"type": "b", "children": [{"type": "t", "text": "Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2009-07-232306"}], "href": "https://doi.org/10.1182/blood-2009-07-232306"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20185589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20185589"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jérémie Boucher, Bernard Masri, Danièle Daviaud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apelin, a newly identified adipokine up-regulated by insulin and obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2004-1427"}], "href": "https://doi.org/10.1210/en.2004-1427"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15677759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15677759"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "L Li, G Yang, Q Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Changes and relations of circulating visfatin, apelin, and resistin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Clin Endocrinol Diabetes (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1055/s-2006-948309"}], "href": "https://doi.org/10.1055/s-2006-948309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17177135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17177135"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Keiko Higuchi, Takayuki Masaki, Koro Gotoh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2006-1270"}], "href": "https://doi.org/10.1210/en.2006-1270"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17347313"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17347313"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Shunming Zhu, Fei Sun, Weijie Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-011-0799-0"}], "href": "https://doi.org/10.1007/s11010-011-0799-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21461612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21461612"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Cédric Dray, Claude Knauf, Danièle Daviaud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apelin stimulates glucose utilization in normal and obese insulin-resistant mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2008.10.003"}], "href": "https://doi.org/10.1016/j.cmet.2008.10.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19046574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19046574"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Suparna M Chandra, Hedi Razavi, Jongmin Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.110.219980"}], "href": "https://doi.org/10.1161/ATVBAHA.110.219980"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21233449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21233449"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Tatsuo Hashimoto, Minoru Kihara, Nozomi Imai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2007.070471"}], "href": "https://doi.org/10.2353/ajpath.2007.070471"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17884970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17884970"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Mélanie Eyries, Géraldine Siegfried, Mariana Ciumas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.108.179333"}], "href": "https://doi.org/10.1161/CIRCRESAHA.108.179333"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18617693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18617693"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Nigel A Chapman, Denis J Dupré, Jan K Rainey "}, {"type": "b", "children": [{"type": "t", "text": "The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1139/bcb-2014-0072"}], "href": "https://doi.org/10.1139/bcb-2014-0072"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25275559"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25275559"}]}]}]}
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| Synonyms | APEL, XNPEP2 |
| Proteins | APEL_HUMAN |
| NCBI Gene ID | 8862 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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APLN has 5,961 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 92 datasets.
Click the + buttons to view associations for APLN from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of APLN gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of APLN gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of APLN gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of APLN gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of APLN gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of APLN gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of APLN gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of APLN gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of APLN gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of APLN gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with APLN gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of APLN gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of APLN gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of APLN gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing APLN protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with APLN protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with APLN protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of APLN gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with APLN gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with APLN gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with APLN gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by APLN gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with APLN gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with APLN gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with APLN gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with APLN gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at APLN gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of APLN gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of APLN gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing APLN from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with APLN gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with APLN gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with APLN gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing APLN from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of APLN gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of APLN gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of APLN gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of APLN gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of APLN gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of APLN gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving APLN gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving APLN gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving APLN gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing APLN protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by APLN gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by APLN gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by APLN gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of APLN gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of APLN gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of APLN gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of APLN gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of APLN gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of APLN gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of APLN gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for APLN from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuBMAP ASCT+B Annotations | cell types associated with APLN gene from the HuBMAP ASCT+B dataset. | |
| HuBMAP ASCT+B Augmented with RNA-seq Coexpression | cell types associated with APLN gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with APLN gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for APLN protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of APLN gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of APLN gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of APLN gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving APLN protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of APLN gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of APLN gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of APLN gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain APLN protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by APLN gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting APLN gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of APLN gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of APLN gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by APLN gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for APLN from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of APLN gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of APLN gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving APLN protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving APLN protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2014 | pathways involving APLN protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving APLN protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of APLN gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at APLN gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of APLN gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of APLN gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of APLN gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of APLN gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of APLN gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of APLN gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of APLN protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of APLN protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of APLN protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with APLN protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with APLN protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
