| HGNC Family | G protein-coupled receptors |
| Name | apelin receptor |
| Description | This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The apelin receptor (APLNR), a G protein–coupled receptor widely expressed in the cardiovascular system, plays a central role in maintaining cardiovascular homeostasis. Ligand binding—by endogenous peptides such as apelin and Elabela/Toddler—elicits potent vasodilatory and positive inotropic effects, mediating blood pressure regulation by increasing nitric oxide bioavailability and opposing angiotensin II–induced vasoconstriction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, upregulation of APLNR in response to changes in ventricular load or hypoxic conditions contributes to adaptive responses in heart failure, further underscoring its cardioprotective function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in the mature heart, APLNR signaling is essential for proper vascular development and angiogenesis. In endothelial cells, activation of APLNR promotes proliferation, migration, and cell–cell aggregation, which in turn support vessel enlargement, stabilization, and maturation. These processes are critical during embryogenesis and in the context of therapeutic angiogenesis, as well as for maintaining endothelial barrier function and preventing hyperpermeability under stress conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the heart, APLNR signaling not only enhances contractility and improves cardiac output but also confers protection against ischemia–reperfusion injury and adverse remodeling. This cardioprotection may be mediated by cross‐talk with the renin–angiotensin system, partly via upregulation of angiotensin‐converting enzyme 2, and is evident in both experimental models of myocardial infarction and clinical contexts of heart failure."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n APLNR also influences metabolic and musculoskeletal homeostasis. Genetic ablation of either apelin or its receptor impairs skeletal muscle function and regenerative capacity during aging, while modulation of the pathway in adipocytes can regulate lipolysis and energy expenditure. These findings suggest that the apelin–APLNR axis contributes to overall metabolic control and may offer therapeutic potential for conditions such as sarcopenia and obesity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "18"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in the pulmonary vasculature and other endothelial beds, APLNR signaling supports vascular integrity and regulates cell polarity in response to shear stress, thereby counteracting pathological remodeling seen in pulmonary hypertension and atherosclerosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "21"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n At the molecular level, recent crystallographic studies have provided detailed insights into ligand recognition by APLNR. The structure of the receptor in complex with an apelin mimetic reveals a two-site binding mode involving a curved, lactam-constrained peptide conformation, offering a mechanistic basis for its specificity and downstream signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, APLNR functions as a critical mediator of cardiovascular, vascular, and metabolic physiology by integrating signals from its diverse endogenous ligands. Its multifaceted roles in vasodilation, cardiac protection, angiogenesis, and metabolic regulation make the apelin–APLNR axis a promising target for therapeutic intervention in a range of cardiovascular and metabolic diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Junji Ishida, Tatsuo Hashimoto, Yasumi Hashimoto, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Vascular effects of apelin in vivo in man."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Coll Cardiol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jacc.2008.06.013"}], "href": "https://doi.org/10.1016/j.jacc.2008.06.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18772060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18772060"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mary M Chen, Euan A Ashley, David X F Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.CIR.0000091235.94914.75"}], "href": "https://doi.org/10.1161/01.CIR.0000091235.94914.75"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12963638"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12963638"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hyung J Chun, Ziad A Ali, Yoko Kojima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI34871"}], "href": "https://doi.org/10.1172/JCI34871"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18769630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18769630"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Matthias J Kleinz, Jeremy N Skepper, Anthony P Davenport "}, {"type": "b", "children": [{"type": "t", "text": "Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Regul Pept (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.regpep.2004.10.019"}], "href": "https://doi.org/10.1016/j.regpep.2004.10.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15664671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15664671"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hiroyasu Kidoya, Masaya Ueno, Yoshihiro Yamada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601982"}], "href": "https://doi.org/10.1038/sj.emboj.7601982"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18200044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18200044"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mélanie Eyries, Géraldine Siegfried, Mariana Ciumas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.108.179333"}], "href": "https://doi.org/10.1161/CIRCRESAHA.108.179333"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18617693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18617693"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yujung Kang, Jongmin Kim, Joshua P Anderson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.113.301324"}], "href": "https://doi.org/10.1161/CIRCRESAHA.113.301324"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23603510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23603510"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hiroyasu Kidoya, Hisamichi Naito, Nobuyuki Takakura "}, {"type": "b", "children": [{"type": "t", "text": "Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2009-07-232306"}], "href": "https://doi.org/10.1182/blood-2009-07-232306"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20185589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20185589"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Roland E Kälin, Martin P Kretz, Andrea M Meyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2007.03.004"}], "href": "https://doi.org/10.1016/j.ydbio.2007.03.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17412318"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17412318"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Gábor Földes, Ferenc Horkay, István Szokodi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-291x(03)01424-4"}], "href": "https://doi.org/10.1016/s0006-291x(03"}, {"type": "t", "text": "01424-4) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12914775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12914775"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Wang Wang, Shaun M K McKinnie, Vaibhav B Patel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Heart Assoc (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/JAHA.113.000249"}], "href": "https://doi.org/10.1161/JAHA.113.000249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23817469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23817469"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Teruki Sato, Takashi Suzuki, Hiroyuki Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apelin is a positive regulator of ACE2 in failing hearts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI69608"}], "href": "https://doi.org/10.1172/JCI69608"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24177423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24177423"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Teruki Sato, Chitose Sato, Ayumi Kadowaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvx061"}], "href": "https://doi.org/10.1093/cvr/cvx061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28371822"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28371822"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xiao-Hua Yu, Zhi-Bin Tang, Li-Jing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apelin and its receptor APJ in cardiovascular diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Chim Acta (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cca.2013.09.001"}], "href": "https://doi.org/10.1016/j.cca.2013.09.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24055369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24055369"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Claire Vinel, Laura Lukjanenko, Aurelie Batut, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The exerkine apelin reverses age-associated sarcopenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41591-018-0131-6"}], "href": "https://doi.org/10.1038/s41591-018-0131-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30061698"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30061698"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Keiko Higuchi, Takayuki Masaki, Koro Gotoh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2006-1270"}], "href": "https://doi.org/10.1210/en.2006-1270"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17347313"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17347313"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Patrick Yue, Hong Jin, Shiming Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apelin decreases lipolysis via G(q), G(i), and AMPK-Dependent Mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2010-0576"}], "href": "https://doi.org/10.1210/en.2010-0576"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21047945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21047945"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Suparna M Chandra, Hedi Razavi, Jongmin Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.110.219980"}], "href": "https://doi.org/10.1161/ATVBAHA.110.219980"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21233449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21233449"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Mika Sawane, Kentaro Kajiya, Hiroyasu Kidoya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apelin inhibits diet-induced obesity by enhancing lymphatic and blood vessel integrity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db12-0604"}], "href": "https://doi.org/10.2337/db12-0604"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23378608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23378608"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Hyouk-Bum Kwon, Shengpeng Wang, Christian S M Helker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In vivo modulation of endothelial polarization by Apelin receptor signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms11805"}], "href": "https://doi.org/10.1038/ncomms11805"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27248505"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27248505"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yingli Ma, Yang Yue, Yanbin Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural Basis for Apelin Control of the Human Apelin Receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2017.04.008"}], "href": "https://doi.org/10.1016/j.str.2017.04.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28528775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28528775"}]}]}]}
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| Synonyms | HG11, APJR, APJ, AGTRL1 |
| Proteins | APJ_HUMAN |
| NCBI Gene ID | 187 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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APLNR has 4,807 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 107 datasets.
Click the + buttons to view associations for APLNR from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of APLNR gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of APLNR gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of APLNR gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of APLNR gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of APLNR gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of APLNR gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of APLNR gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of APLNR gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of APLNR gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of APLNR gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of APLNR gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with APLNR gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of APLNR gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of APLNR gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of APLNR gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of APLNR gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing APLNR protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing APLNR protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with APLNR protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with APLNR protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of APLNR gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with APLNR gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Disease Associations | diseases associated with APLNR gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by APLNR gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with APLNR gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with APLNR gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with APLNR gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with APLNR gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at APLNR gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of APLNR gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of APLNR gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing APLNR from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with APLNR gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with APLNR gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of APLNR gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with APLNR gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing APLNR from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of APLNR gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of APLNR gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of APLNR gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of APLNR gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of APLNR gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of APLNR gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving APLNR gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving APLNR gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving APLNR gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing APLNR protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by APLNR gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by APLNR gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by APLNR gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of APLNR gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of APLNR gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of APLNR gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| Guide to Pharmacology Chemical Ligands of Receptors | ligands (chemical) binding APLNR receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. | |
| Guide to Pharmacology Protein Ligands of Receptors | ligands (protein) binding APLNR receptor from the curated Guide to Pharmacology Protein Ligands of Receptors dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with APLNR gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with APLNR gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of APLNR gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of APLNR gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of APLNR protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of APLNR gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HuBMAP ASCT+B Annotations | cell types associated with APLNR gene from the HuBMAP ASCT+B dataset. | |
| HuBMAP ASCT+B Augmented with RNA-seq Coexpression | cell types associated with APLNR gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with APLNR gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with APLNR gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by APLNR gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for APLNR protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of APLNR gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of APLNR gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of APLNR gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving APLNR protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of APLNR gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of APLNR gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of APLNR gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of APLNR gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of APLNR gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing APLNR protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain APLNR protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by APLNR gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting APLNR gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of APLNR gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of APLNR gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by APLNR gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of APLNR gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for APLNR from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of APLNR gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of APLNR gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving APLNR protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving APLNR protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2014 | pathways involving APLNR protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving APLNR protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of APLNR gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at APLNR gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of APLNR gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of APLNR gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of APLNR gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of APLNR gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of APLNR gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of APLNR gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of APLNR protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of APLNR protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of APLNR protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of APLNR protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with APLNR protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with APLNR protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2014 | pathways involving APLNR protein from the Wikipathways Pathways 2014 dataset. | |
| WikiPathways Pathways 2024 | pathways involving APLNR protein from the WikiPathways Pathways 2024 dataset. | |
