{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The long non‐coding antisense RNA AQP4‑AS1 has emerged as a versatile regulator in diverse biological contexts. In diabetic retinopathy, for example, AQP4‑AS1 expression is significantly up‐regulated in patient samples, high glucose‑treated Müller cells, and diabetic retinas in animal models; its silencing alleviates retinal neurodegeneration and vascular dysfunction by modulating the expression of the AQP4 gene (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In neuropsychiatric disorders, bioinformatic analyses have identified an AQP4‑AS1–mediated competing endogenous RNA axis that may influence gene regulation in the olfactory epithelium, thereby contributing to schizophrenia pathophysiology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In oncologic settings, genetic studies in breast cancer have linked single nucleotide polymorphisms in AQP4‑AS1 with disease susceptibility and prognosis; its down‑regulation correlates with more aggressive tumors and poorer outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in gastric cancer, AQP4‑AS1 appears within a regulatory network where its expression is associated with overall survival risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, transcriptome analyses in epileptogenic hippocampal tissues have identified aberrant levels of AQP4‑AS1 among other dysregulated non‑coding RNAs, suggesting a role in neuroinflammation and synaptic modulation in drug‑refractory mesial temporal lobe epilepsy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that AQP4‑AS1 functions as a critical regulatory molecule whose altered expression impacts retinal neurovascular integrity, neuronal gene expression networks, and tumor progression, making it a promising candidate for further investigation as both a biomarker and a therapeutic target across a range of diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiumiao Li, Junya Zhu, Yuling Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting long noncoding RNA-AQP4-AS1 for the treatment of retinal neurovascular dysfunction in diabetes mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2022.103857"}], "href": "https://doi.org/10.1016/j.ebiom.2022.103857"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35172268"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35172268"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hani Sabaie, Marziyeh Mazaheri Moghaddam, Madiheh Mazaheri Moghaddam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA-associated competing endogenous RNA axes in the olfactory epithelium in schizophrenia: a bioinformatics analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-04326-0"}], "href": "https://doi.org/10.1038/s41598-021-04326-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34969953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34969953"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rafael D Marchi, Carolina Mathias, Gabriel A K Reiter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between SNP rs527616 in lncRNA AQP4-AS1 and susceptibility to breast cancer in a southern Brazilian population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1590/1678-4685-GMB-2020-0216"}], "href": "https://doi.org/10.1590/1678-4685-GMB-2020-0216"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33721012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33721012"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chao Xing, Zhengzhai Cai, Jian Gong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Potential Biomarkers Involved in Gastric Cancer Through Integrated Analysis of Non-Coding RNA Associated Competing Endogenous RNAs Network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Lab (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7754/Clin.Lab.2018.180419"}], "href": "https://doi.org/10.7754/Clin.Lab.2018.180419"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30336538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30336538"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Aparna Banerjee Dixit, Jyotirmoy Banerjee, Arpna Srivastava, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA-seq analysis of hippocampal tissues reveals novel candidate genes for drug refractory epilepsy in patients with MTLE-HS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2016.04.001"}], "href": "https://doi.org/10.1016/j.ygeno.2016.04.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27094248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27094248"}]}]}]}