{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNAs (lncRNAs) are increasingly recognized for their involvement in gene regulation and cancer biology. In a recent study investigating lung adenocarcinoma (LAD), ARHGAP22‐IT1 was identified as one of several lncRNAs exhibiting differential expression between tumor tissues—with and without lymphatic metastasis—and adjacent non-tumor lung tissues. The observed alteration in ARHGAP22‐IT1 expression, which was validated by quantitative real-time PCR to be consistent with microarray data, highlights its potential as a biomarker for LAD diagnosis and possibly for assessing metastatic progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhiyi Yang, Hongli Li, Zhaoyan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microarray expression profile of long non-coding RNAs in human lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.12845"}], "href": "https://doi.org/10.1111/1759-7714.12845"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30151992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30151992"}]}]}]}